-- dump date 20111121_015659 -- class Genbank::misc_feature -- table misc_feature_note -- id note 291331000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 291331000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331000003 Walker A motif; other site 291331000004 ATP binding site [chemical binding]; other site 291331000005 Walker B motif; other site 291331000006 arginine finger; other site 291331000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 291331000008 DnaA box-binding interface [nucleotide binding]; other site 291331000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 291331000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 291331000011 putative DNA binding surface [nucleotide binding]; other site 291331000012 dimer interface [polypeptide binding]; other site 291331000013 beta-clamp/clamp loader binding surface; other site 291331000014 beta-clamp/translesion DNA polymerase binding surface; other site 291331000015 recombination protein F; Reviewed; Region: recF; PRK00064 291331000016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331000017 Walker A/P-loop; other site 291331000018 ATP binding site [chemical binding]; other site 291331000019 Q-loop/lid; other site 291331000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331000021 ABC transporter signature motif; other site 291331000022 Walker B; other site 291331000023 D-loop; other site 291331000024 H-loop/switch region; other site 291331000025 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 291331000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 291331000027 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 291331000028 anchoring element; other site 291331000029 dimer interface [polypeptide binding]; other site 291331000030 ATP binding site [chemical binding]; other site 291331000031 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 291331000032 active site 291331000033 putative metal-binding site [ion binding]; other site 291331000034 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 291331000035 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 291331000036 Peptidase family M48; Region: Peptidase_M48; cl12018 291331000037 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 291331000038 Gram-negative bacterial tonB protein; Region: TonB; cl10048 291331000039 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 291331000040 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 291331000041 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 291331000042 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 291331000043 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 291331000044 active site 291331000045 hydrophilic channel; other site 291331000046 dimerization interface [polypeptide binding]; other site 291331000047 catalytic residues [active] 291331000048 active site lid [active] 291331000049 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 291331000050 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 291331000051 putative active site [active] 291331000052 catalytic site [active] 291331000053 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 291331000054 putative active site [active] 291331000055 catalytic site [active] 291331000056 fructose-1,6-bisphosphatase family protein; Region: PLN02628 291331000057 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354 291331000058 AMP binding site [chemical binding]; other site 291331000059 metal binding site [ion binding]; metal-binding site 291331000060 active site 291331000061 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 291331000062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331000063 homodimer interface [polypeptide binding]; other site 291331000064 catalytic residue [active] 291331000065 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 291331000066 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331000067 N-terminal plug; other site 291331000068 ligand-binding site [chemical binding]; other site 291331000069 Transposase domain (DUF772); Region: DUF772; cl12084 291331000070 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331000071 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 291331000072 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 291331000073 phosphate binding site [ion binding]; other site 291331000074 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 291331000075 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 291331000076 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 291331000077 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 291331000078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331000079 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 291331000080 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 291331000081 substrate binding site [chemical binding]; other site 291331000082 ATP binding site [chemical binding]; other site 291331000083 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331000084 Transposase domain (DUF772); Region: DUF772; cl12084 291331000085 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331000086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 291331000087 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331000088 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331000089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331000090 EcsC protein family; Region: EcsC; pfam12787 291331000091 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 291331000092 putative hydrophobic ligand binding site [chemical binding]; other site 291331000093 proline/glycine betaine transporter; Provisional; Region: PRK10642 291331000094 proline/glycine betaine transporter; Provisional; Region: PRK10642 291331000095 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331000096 Integrase core domain; Region: rve; cl01316 291331000097 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 291331000098 catalytic residues [active] 291331000099 Protein required for attachment to host cells; Region: Host_attach; cl02398 291331000100 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_20; cd04679 291331000101 nudix motif; other site 291331000102 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331000103 Integrase core domain; Region: rve; cl01316 291331000104 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331000105 Integrase core domain; Region: rve; cl01316 291331000106 Transposase domain (DUF772); Region: DUF772; cl12084 291331000107 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331000108 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 291331000109 TIGR01777 family protein; Region: yfcH 291331000110 putative NAD(P) binding site [chemical binding]; other site 291331000111 putative active site [active] 291331000112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 291331000113 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 291331000114 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 291331000115 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 291331000116 protein binding site [polypeptide binding]; other site 291331000117 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 291331000118 protein binding site [polypeptide binding]; other site 291331000119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000120 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000122 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 291331000123 NolX protein; Region: NolX; pfam05819 291331000124 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000125 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000126 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000127 Transposase domain (DUF772); Region: DUF772; cl12084 291331000128 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000129 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000130 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 291331000131 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 291331000132 FliP family; Region: FliP; cl00593 291331000133 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 291331000134 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 291331000135 Type III secretion protein (HpaP); Region: HpaP; cl09717 291331000136 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 291331000137 FHIPEP family; Region: FHIPEP; pfam00771 291331000138 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; pfam01312 291331000139 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 291331000140 Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; cl09830 291331000141 Bacterial type III secretion protein (HrpB2); Region: HrpB2; cl09721 291331000142 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 291331000143 Bacterial type III secretion protein (HrpB4); Region: HrpB4; cl09735 291331000144 type III secretion system protein HrpB; Validated; Region: PRK09098 291331000145 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 291331000146 type III secretion system ATPase; Provisional; Region: PRK09099 291331000147 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 291331000148 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 291331000149 Walker A motif/ATP binding site; other site 291331000150 Walker B motif; other site 291331000151 Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720 291331000152 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 291331000153 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 291331000154 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 291331000155 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 291331000156 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 291331000157 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 291331000158 N-acetyl-D-glucosamine binding site [chemical binding]; other site 291331000159 catalytic residue [active] 291331000161 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 291331000162 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 291331000163 Mechanosensitive ion channel; Region: MS_channel; pfam00924 291331000164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000165 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 291331000166 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 291331000167 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 291331000168 Protein of unknown function (DUF808); Region: DUF808; cl01002 291331000169 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 291331000170 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331000171 metal binding site [ion binding]; metal-binding site 291331000172 active site 291331000173 I-site; other site 291331000174 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 291331000175 glycogen synthase; Provisional; Region: glgA; PRK00654 291331000176 ADP-binding pocket [chemical binding]; other site 291331000177 homodimer interface [polypeptide binding]; other site 291331000178 glycogen branching enzyme; Provisional; Region: PRK12568 291331000179 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 291331000180 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 291331000181 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 291331000182 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 291331000183 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 291331000184 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 291331000185 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 291331000186 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 291331000187 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 291331000188 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 291331000189 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 291331000190 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 291331000191 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 291331000192 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 291331000193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331000194 NAD(P) binding site [chemical binding]; other site 291331000195 active site 291331000196 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 291331000197 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000198 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000199 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000200 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331000201 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331000202 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 291331000203 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000206 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000207 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000208 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 291331000210 hypothetical protein; Provisional; Region: PRK09897 291331000211 VirK protein; Region: VirK; pfam06903 291331000212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 291331000213 DEAD-like helicases superfamily; Region: DEXDc; smart00487 291331000214 ATP binding site [chemical binding]; other site 291331000215 putative Mg++ binding site [ion binding]; other site 291331000216 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331000217 nucleotide binding region [chemical binding]; other site 291331000218 ATP-binding site [chemical binding]; other site 291331000219 Transposase domain (DUF772); Region: DUF772; cl12084 291331000220 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331000221 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 291331000222 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331000223 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 291331000224 Transposase domain (DUF772); Region: DUF772; cl12084 291331000225 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000226 Transposase domain (DUF772); Region: DUF772; cl12084 291331000227 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000228 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000229 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331000230 Integrase core domain; Region: rve; cl01316 291331000231 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331000232 Integrase core domain; Region: rve; cl01316 291331000233 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 291331000234 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 291331000235 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 291331000236 Walker A/P-loop; other site 291331000237 ATP binding site [chemical binding]; other site 291331000238 Q-loop/lid; other site 291331000239 ABC transporter signature motif; other site 291331000240 Walker B; other site 291331000241 D-loop; other site 291331000242 H-loop/switch region; other site 291331000243 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 291331000244 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 291331000245 FtsX-like permease family; Region: FtsX; pfam02687 291331000246 Integrase core domain; Region: rve; cl01316 291331000247 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331000248 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331000249 HSP20-like domain of unknown function (DUF1813); Region: DUF1813; cl07446 291331000250 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 291331000251 Phd_YefM; Region: PhdYeFM; cl09153 291331000252 Haemolysin-III related; Region: HlyIII; cl03831 291331000253 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 291331000254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 291331000255 ATP binding site [chemical binding]; other site 291331000256 putative Mg++ binding site [ion binding]; other site 291331000257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331000258 nucleotide binding region [chemical binding]; other site 291331000259 ATP-binding site [chemical binding]; other site 291331000260 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 291331000261 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 291331000262 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 291331000263 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 291331000264 putative active site [active] 291331000265 catalytic site [active] 291331000266 putative metal binding site [ion binding]; other site 291331000267 oligomer interface [polypeptide binding]; other site 291331000268 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 291331000269 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 291331000271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 291331000272 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 291331000273 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 291331000274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331000275 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 291331000276 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes...; Region: Topo_IB_C; cd00659 291331000277 DNA binding site [nucleotide binding] 291331000278 active site 291331000279 Int/Topo IB signature motif; other site 291331000280 catalytic residues [active] 291331000281 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 291331000282 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 291331000283 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 291331000284 active site 291331000285 dimer interface [polypeptide binding]; other site 291331000286 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 291331000287 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 291331000288 active site 291331000289 FMN binding site [chemical binding]; other site 291331000290 substrate binding site [chemical binding]; other site 291331000291 3Fe-4S cluster binding site [ion binding]; other site 291331000292 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 291331000293 domain interface; other site 291331000294 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 291331000295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331000296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331000297 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331000298 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331000299 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331000300 Integrase core domain; Region: rve; cl01316 291331000301 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000302 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000303 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000304 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000305 Transposase domain (DUF772); Region: DUF772; cl12084 291331000306 KduI/IolB family; Region: KduI; cl01508 291331000307 Transcriptional regulators [Transcription]; Region: PurR; COG1609 291331000308 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 291331000309 DNA binding site [nucleotide binding] 291331000310 domain linker motif; other site 291331000311 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 291331000312 putative dimerization interface [polypeptide binding]; other site 291331000313 putative ligand binding site [chemical binding]; other site 291331000314 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 291331000315 glycogen branching enzyme; Provisional; Region: PRK05402 291331000316 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 291331000317 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 291331000318 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 291331000319 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 291331000321 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 291331000322 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 291331000323 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331000324 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331000325 Transposase domain (DUF772); Region: DUF772; cl12084 291331000326 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000327 Mg chelatase-related protein; Region: TIGR00368 291331000328 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331000329 Membrane fusogenic activity; Region: BMFP; cl01115 291331000330 Nitrogen regulatory protein P-II; Region: P-II; cl00412 291331000331 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 291331000332 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 291331000333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331000334 spermidine synthase; Provisional; Region: PRK00811 291331000335 arginine decarboxylase; Provisional; Region: PRK05354 291331000336 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 291331000337 dimer interface [polypeptide binding]; other site 291331000338 active site 291331000339 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 291331000340 catalytic residues [active] 291331000341 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 291331000342 Transposase domain (DUF772); Region: DUF772; cl12084 291331000343 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 291331000344 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331000345 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331000346 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 291331000347 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 291331000348 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 291331000349 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 291331000350 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 291331000351 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 291331000352 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 291331000353 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 291331000354 serine racemase; Region: PLN02970 291331000355 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 291331000356 tetramer interface [polypeptide binding]; other site 291331000357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331000358 catalytic residue [active] 291331000359 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 291331000360 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 291331000361 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 291331000362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331000363 S-adenosylmethionine binding site [chemical binding]; other site 291331000364 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 291331000365 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 291331000366 putative NAD(P) binding site [chemical binding]; other site 291331000367 putative active site [active] 291331000368 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 291331000369 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl01208 291331000370 GAF domain; Region: GAF; cl00853 291331000371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 291331000372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331000373 ATP binding site [chemical binding]; other site 291331000374 Mg2+ binding site [ion binding]; other site 291331000375 G-X-G motif; other site 291331000376 Thymidine kinase; Region: TK; cl00631 291331000377 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 291331000378 UvrD/REP helicase; Region: UvrD-helicase; cl14126 291331000379 hypothetical protein; Provisional; Region: PRK11239 291331000380 Protein of unknown function, DUF480; Region: DUF480; cl01209 291331000381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 291331000382 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 291331000383 active site 291331000384 dimer interface [polypeptide binding]; other site 291331000385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331000386 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 291331000387 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331000388 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 291331000389 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331000390 lac repressor; Reviewed; Region: lacI; PRK09526 291331000391 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 291331000392 DNA binding site [nucleotide binding] 291331000393 domain linker motif; other site 291331000394 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 291331000395 dimerization interface [polypeptide binding]; other site 291331000396 ligand binding site [chemical binding]; other site 291331000397 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 291331000398 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 291331000399 putative acyl-acceptor binding pocket; other site 291331000400 Protein of unknown function (DUF465); Region: DUF465; cl01070 291331000401 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331000402 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 291331000403 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 291331000404 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 291331000405 active site 291331000406 oxyanion hole [active] 291331000407 Protein of unknown function (DUF3532); Region: DUF3532; pfam12050 291331000408 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH)...; Region: pro_PheOH; cd03348 291331000409 cofactor binding site; other site 291331000410 metal binding site [ion binding]; metal-binding site 291331000411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331000412 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331000413 Transposase domain (DUF772); Region: DUF772; cl12084 291331000414 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 291331000415 Transposase domain (DUF772); Region: DUF772; cl12084 291331000416 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000417 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000418 cinnamyl-alcohol dehydrogenase; Region: PLN02514 291331000419 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 291331000420 putative NAD(P) binding site [chemical binding]; other site 291331000421 putative substrate binding site [chemical binding]; other site 291331000422 catalytic Zn binding site [ion binding]; other site 291331000423 structural Zn binding site [ion binding]; other site 291331000424 dimer interface [polypeptide binding]; other site 291331000425 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 291331000426 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 291331000427 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 291331000428 Integrase core domain; Region: rve; cl01316 291331000429 hypothetical protein; Provisional; Region: PRK04233 291331000430 SEC-C motif; Region: SEC-C; cl12132 291331000431 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 291331000432 lytic murein transglycosylase; Region: MltB_2; TIGR02283 291331000433 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 291331000434 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 291331000435 active site 291331000436 phosphate binding residues; other site 291331000437 catalytic residues [active] 291331000439 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 291331000440 heme binding pocket [chemical binding]; other site 291331000441 heme ligand [chemical binding]; other site 291331000442 PAS fold; Region: PAS_2; pfam08446 291331000443 GAF domain; Region: GAF; cl00853 291331000444 Phytochrome region; Region: PHY; pfam00360 291331000445 Integrase core domain; Region: rve; cl01316 291331000446 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331000447 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000448 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 291331000449 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 291331000450 DNA binding site [nucleotide binding] 291331000451 catalytic residue [active] 291331000452 H2TH interface [polypeptide binding]; other site 291331000453 putative catalytic residues [active] 291331000454 turnover-facilitating residue; other site 291331000455 intercalation triad [nucleotide binding]; other site 291331000456 8OG recognition residue [nucleotide binding]; other site 291331000457 putative reading head residues; other site 291331000458 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 291331000459 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 291331000460 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331000461 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331000462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000463 Transposase domain (DUF772); Region: DUF772; cl12084 291331000464 VacJ like lipoprotein; Region: VacJ; cl01073 291331000465 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 291331000466 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 291331000467 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 291331000468 mce related protein; Region: MCE; cl03606 291331000469 Domain of unknown function DUF140; Region: DUF140; cl00510 291331000470 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 291331000471 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 291331000472 Walker A/P-loop; other site 291331000473 ATP binding site [chemical binding]; other site 291331000474 Q-loop/lid; other site 291331000475 ABC transporter signature motif; other site 291331000476 Walker B; other site 291331000477 D-loop; other site 291331000478 H-loop/switch region; other site 291331000479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331000480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331000481 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331000482 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331000483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331000484 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331000485 Integrase core domain; Region: rve; cl01316 291331000486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000487 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000490 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000491 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000493 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331000494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331000496 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331000497 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331000498 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505 291331000499 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 291331000500 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 291331000501 Trp docking motif; other site 291331000502 'Velcro' closure; other site 291331000503 active site 291331000504 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 291331000505 ATP-binding site [chemical binding]; other site 291331000506 Gluconate-6-phosphate binding site [chemical binding]; other site 291331000507 putative symporter YagG; Provisional; Region: PRK09669 291331000508 putative transporter; Provisional; Region: PRK11462 291331000509 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 291331000510 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 291331000511 DNA primase; Provisional; Region: PRK04031 291331000512 Sodium:solute symporter family; Region: SSF; cl00456 291331000513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 291331000514 PAS fold; Region: PAS_7; pfam12860 291331000515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331000516 dimer interface [polypeptide binding]; other site 291331000517 phosphorylation site [posttranslational modification] 291331000518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331000519 ATP binding site [chemical binding]; other site 291331000520 Mg2+ binding site [ion binding]; other site 291331000521 G-X-G motif; other site 291331000522 Response regulator receiver domain; Region: Response_reg; pfam00072 291331000523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331000524 active site 291331000525 phosphorylation site [posttranslational modification] 291331000526 intermolecular recognition site; other site 291331000527 dimerization interface [polypeptide binding]; other site 291331000528 Predicted membrane protein [Function unknown]; Region: COG1971 291331000529 Domain of unknown function DUF; Region: DUF204; pfam02659 291331000530 Domain of unknown function DUF; Region: DUF204; pfam02659 291331000531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331000532 Bacterial transcriptional regulator; Region: IclR; pfam01614 291331000533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 291331000534 glucose/galactose transporter; Region: gluP; TIGR01272 291331000535 Domain of unknown function (DUF718); Region: DUF718; cl01281 291331000536 Transposase domain (DUF772); Region: DUF772; cl12084 291331000537 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331000538 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331000539 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 291331000540 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 291331000541 active site 291331000542 Zn binding site [ion binding]; other site 291331000543 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 291331000544 putative acyl-acceptor binding pocket; other site 291331000545 RF-1 domain; Region: RF-1; cl02875 291331000546 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 291331000547 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 291331000548 active site 291331000549 Cupin domain; Region: Cupin_2; cl09118 291331000550 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 291331000551 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 291331000552 SCP-2 sterol transfer family; Region: SCP2; cl01225 291331000553 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 291331000554 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 291331000555 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331000556 Transposase domain (DUF772); Region: DUF772; cl12084 291331000557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000558 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331000559 Integrase core domain; Region: rve; cl01316 291331000560 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000561 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000562 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000564 Transposase domain (DUF772); Region: DUF772; cl12084 291331000565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331000566 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331000567 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 291331000568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331000569 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 291331000570 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 291331000571 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 291331000572 ABC-2 type transporter; Region: ABC2_membrane; cl11417 291331000573 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 291331000574 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 291331000575 Walker A/P-loop; other site 291331000576 ATP binding site [chemical binding]; other site 291331000577 Q-loop/lid; other site 291331000578 ABC transporter signature motif; other site 291331000579 Walker B; other site 291331000580 D-loop; other site 291331000581 H-loop/switch region; other site 291331000582 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 291331000583 FAD binding pocket [chemical binding]; other site 291331000584 FAD binding motif [chemical binding]; other site 291331000585 phosphate binding motif [ion binding]; other site 291331000586 beta-alpha-beta structure motif; other site 291331000587 NAD binding pocket [chemical binding]; other site 291331000588 Cation efflux family; Region: Cation_efflux; cl00316 291331000589 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 291331000590 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 291331000591 putative metal binding site [ion binding]; other site 291331000592 putative homotetramer interface [polypeptide binding]; other site 291331000593 putative homodimer interface [polypeptide binding]; other site 291331000594 putative homodimer-homodimer interface [polypeptide binding]; other site 291331000595 putative allosteric switch controlling residues; other site 291331000596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 291331000597 non-specific DNA binding site [nucleotide binding]; other site 291331000598 salt bridge; other site 291331000599 sequence-specific DNA binding site [nucleotide binding]; other site 291331000600 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 291331000601 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 291331000602 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331000603 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 291331000604 NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at...; Region: ABC_NatA_sodium_exporter; cd03266 291331000605 Walker A/P-loop; other site 291331000606 ATP binding site [chemical binding]; other site 291331000607 Q-loop/lid; other site 291331000608 ABC transporter signature motif; other site 291331000609 Walker B; other site 291331000610 D-loop; other site 291331000611 H-loop/switch region; other site 291331000612 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 291331000613 ABC-2 type transporter; Region: ABC2_membrane; cl11417 291331000614 Gram-negative bacterial tonB protein; Region: TonB; cl10048 291331000615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331000616 SapC; Region: SapC; pfam07277 291331000617 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331000618 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331000619 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331000620 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331000621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331000622 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 291331000623 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 291331000624 C-terminal domain interface [polypeptide binding]; other site 291331000625 GSH binding site (G-site) [chemical binding]; other site 291331000626 dimer interface [polypeptide binding]; other site 291331000627 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 291331000628 dimer interface [polypeptide binding]; other site 291331000629 N-terminal domain interface [polypeptide binding]; other site 291331000630 putative substrate binding pocket (H-site) [chemical binding]; other site 291331000631 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 291331000632 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 291331000633 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 291331000634 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331000635 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 291331000636 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 291331000637 dimer interface [polypeptide binding]; other site 291331000638 allosteric magnesium binding site [ion binding]; other site 291331000639 active site 291331000640 aspartate-rich active site metal binding site; other site 291331000641 Schiff base residues; other site 291331000642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331000643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331000644 NAD(P) binding site [chemical binding]; other site 291331000645 active site 291331000646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331000647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331000648 dimerization interface [polypeptide binding]; other site 291331000649 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 291331000650 active site 291331000651 substrate binding site [chemical binding]; other site 291331000652 Mg2+ binding site [ion binding]; other site 291331000653 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 291331000654 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 291331000655 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 291331000656 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 291331000657 FAD binding pocket [chemical binding]; other site 291331000658 FAD binding motif [chemical binding]; other site 291331000659 catalytic residues [active] 291331000660 NAD binding pocket [chemical binding]; other site 291331000661 phosphate binding motif [ion binding]; other site 291331000662 beta-alpha-beta structure motif; other site 291331000663 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 291331000664 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 291331000665 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 291331000666 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 291331000667 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 291331000668 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 291331000669 NAD(P) binding site [chemical binding]; other site 291331000670 shikimate binding site; other site 291331000671 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 291331000672 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 291331000673 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 291331000674 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331000675 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331000676 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 291331000677 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 291331000678 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 291331000679 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 291331000680 tetramer interface [polypeptide binding]; other site 291331000681 heme binding pocket [chemical binding]; other site 291331000682 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 291331000683 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 291331000684 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 291331000685 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 291331000686 FMN binding site [chemical binding]; other site 291331000687 active site 291331000688 catalytic residues [active] 291331000689 substrate binding site [chemical binding]; other site 291331000690 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 291331000691 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 291331000692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331000693 active site 291331000694 phosphorylation site [posttranslational modification] 291331000695 intermolecular recognition site; other site 291331000696 dimerization interface [polypeptide binding]; other site 291331000697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331000698 DNA binding site [nucleotide binding] 291331000699 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 291331000700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331000701 dimer interface [polypeptide binding]; other site 291331000702 phosphorylation site [posttranslational modification] 291331000703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331000704 ATP binding site [chemical binding]; other site 291331000705 G-X-G motif; other site 291331000706 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 291331000707 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 291331000708 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 291331000709 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 291331000710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331000711 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 291331000712 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 291331000713 Sporulation related domain; Region: SPOR; cl10051 291331000714 thymidylate kinase; Validated; Region: tmk; PRK00698 291331000715 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 291331000716 TMP-binding site; other site 291331000717 ATP-binding site [chemical binding]; other site 291331000718 Picornavirus 2B protein; Region: Pico_P2B; pfam01552 291331000719 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 291331000720 Arginase family; Region: Arginase; cl00306 291331000721 CsbD-like; Region: CsbD; cl01272 291331000722 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 291331000723 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 291331000724 active site 291331000725 HIGH motif; other site 291331000726 dimer interface [polypeptide binding]; other site 291331000727 KMSKS motif; other site 291331000728 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 291331000729 M28, and M42; Region: Zinc_peptidase_like; cl14876 291331000730 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-...; Region: PA_M28_1_2; cd04821 291331000731 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 291331000732 PA/protease or protease-like domain interface [polypeptide binding]; other site 291331000733 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 291331000734 metal binding site [ion binding]; metal-binding site 291331000735 EamA-like transporter family; Region: EamA; cl01037 291331000736 Predicted permeases [General function prediction only]; Region: RarD; COG2962 291331000737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 291331000738 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331000739 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 291331000740 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 291331000741 putative heme binding pocket [chemical binding]; other site 291331000742 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 291331000743 RNA polymerase sigma factor; Provisional; Region: PRK12511 291331000744 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 291331000745 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 291331000746 interface (dimer of trimers) [polypeptide binding]; other site 291331000747 Substrate-binding/catalytic site; other site 291331000748 Zn-binding sites [ion binding]; other site 291331000749 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 291331000750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 291331000751 motif II; other site 291331000752 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 291331000753 Domain of unknown function DUF20; Region: UPF0118; cl00465 291331000754 UbiA prenyltransferase family; Region: UbiA; cl00337 291331000755 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 291331000756 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 291331000757 biotin synthase; Provisional; Region: PRK15108 291331000758 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 291331000759 FeS/SAM binding site; other site 291331000760 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 291331000761 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 291331000762 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291331000763 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331000764 catalytic residue [active] 291331000765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331000766 Integrase core domain; Region: rve; cl01316 291331000767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331000768 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 291331000769 NAD(P) binding site [chemical binding]; other site 291331000770 active site 291331000771 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 291331000772 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331000773 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 291331000774 Ligand binding site [chemical binding]; other site 291331000775 Putative Catalytic site [active] 291331000776 DXD motif; other site 291331000777 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 291331000778 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 291331000779 dimer interface [polypeptide binding]; other site 291331000780 active site 291331000781 YcgL domain; Region: YcgL; cl01189 291331000783 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 291331000784 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 291331000785 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 291331000786 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 291331000787 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 291331000788 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000789 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 291331000790 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 291331000791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331000792 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 291331000793 MgtE intracellular N domain; Region: MgtE_N; cl15244 291331000794 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 291331000795 Divalent cation transporter; Region: MgtE; cl00786 291331000796 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 291331000797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331000798 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 291331000799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331000800 Integral membrane protein TerC family; Region: TerC; cl10468 291331000801 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 291331000802 Class I ribonucleotide reductase; Region: RNR_I; cd01679 291331000803 active site 291331000804 dimer interface [polypeptide binding]; other site 291331000805 catalytic residues [active] 291331000806 effector binding site; other site 291331000807 R2 peptide binding site; other site 291331000808 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 291331000809 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 291331000810 dimer interface [polypeptide binding]; other site 291331000811 putative radical transfer pathway; other site 291331000812 diiron center [ion binding]; other site 291331000813 tyrosyl radical; other site 291331000814 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 291331000815 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 291331000816 catalytic residues [active] 291331000817 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331000818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 291331000819 Integrase core domain; Region: rve; cl01316 291331000820 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 291331000821 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 291331000822 dimer interface [polypeptide binding]; other site 291331000823 active site 291331000824 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 291331000825 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 291331000826 Active site [active] 291331000827 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 291331000828 heterodimer interface [polypeptide binding]; other site 291331000829 active site 291331000830 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 291331000831 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 291331000832 tetramer interface [polypeptide binding]; other site 291331000833 active site 291331000834 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 291331000835 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 291331000836 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 291331000837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331000838 Bacterial transcriptional regulator; Region: IclR; pfam01614 291331000839 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 291331000840 ATP binding site [chemical binding]; other site 291331000841 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331000842 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 291331000843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331000844 NAD(P) binding site [chemical binding]; other site 291331000845 active site 291331000846 Sporulation related domain; Region: SPOR; cl10051 291331000847 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 291331000848 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 291331000849 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 291331000850 active site 291331000851 HIGH motif; other site 291331000852 KMSK motif region; other site 291331000853 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 291331000854 tRNA binding surface [nucleotide binding]; other site 291331000855 anticodon binding site; other site 291331000856 hypothetical protein; Reviewed; Region: PRK00024 291331000857 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 291331000858 MPN+ (JAMM) motif; other site 291331000859 Zinc-binding site [ion binding]; other site 291331000860 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 291331000861 Flavoprotein; Region: Flavoprotein; cl08021 291331000862 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 291331000863 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 291331000864 trimer interface [polypeptide binding]; other site 291331000865 active site 291331000866 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 291331000867 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 291331000868 active site 291331000869 substrate binding site [chemical binding]; other site 291331000870 metal binding site [ion binding]; metal-binding site 291331000871 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 291331000872 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 291331000873 Ligand binding site [chemical binding]; other site 291331000874 Putative Catalytic site [active] 291331000875 DXD motif; other site 291331000876 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 291331000877 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 291331000878 putative NAD(P) binding site [chemical binding]; other site 291331000879 active site 291331000880 putative substrate binding site [chemical binding]; other site 291331000881 TfoX N-terminal domain; Region: TfoX_N; cl01167 291331000882 ParB-like partition proteins; Region: parB_part; TIGR00180 291331000883 ParB-like nuclease domain; Region: ParBc; cl02129 291331000884 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 291331000885 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 291331000886 P-loop; other site 291331000887 Magnesium ion binding site [ion binding]; other site 291331000888 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 291331000889 Magnesium ion binding site [ion binding]; other site 291331000890 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 291331000891 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 291331000892 putative active site [active] 291331000893 putative DNA binding site [nucleotide binding]; other site 291331000894 putative phosphate binding site [ion binding]; other site 291331000895 putative catalytic site [active] 291331000896 metal binding site A [ion binding]; metal-binding site 291331000897 putative AP binding site [nucleotide binding]; other site 291331000898 putative metal binding site B [ion binding]; other site 291331000899 muropeptide transporter; Reviewed; Region: ampG; PRK11902 291331000900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 291331000901 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 291331000902 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 291331000903 putative peptidase; Provisional; Region: PRK11649 291331000904 Peptidase family M23; Region: Peptidase_M23; pfam01551 291331000905 Integrase core domain; Region: rve; cl01316 291331000906 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331000907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331000908 dimer interface [polypeptide binding]; other site 291331000909 phosphorylation site [posttranslational modification] 291331000910 histidine kinase; Provisional; Region: PRK13557 291331000911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331000912 ATP binding site [chemical binding]; other site 291331000913 Mg2+ binding site [ion binding]; other site 291331000914 G-X-G motif; other site 291331000915 Response regulator receiver domain; Region: Response_reg; pfam00072 291331000916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331000917 active site 291331000918 phosphorylation site [posttranslational modification] 291331000919 intermolecular recognition site; other site 291331000920 dimerization interface [polypeptide binding]; other site 291331000921 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 291331000922 Response regulator receiver domain; Region: Response_reg; pfam00072 291331000923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331000924 active site 291331000925 phosphorylation site [posttranslational modification] 291331000926 intermolecular recognition site; other site 291331000927 dimerization interface [polypeptide binding]; other site 291331000928 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 291331000929 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 291331000930 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 291331000931 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 291331000932 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 291331000933 Secretory lipase; Region: LIP; pfam03583 291331000934 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 291331000935 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 291331000936 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 291331000937 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 291331000938 putative NADH binding site [chemical binding]; other site 291331000939 putative active site [active] 291331000940 nudix motif; other site 291331000941 putative metal binding site [ion binding]; other site 291331000942 CobD/Cbib protein; Region: CobD_Cbib; cl00561 291331000943 Interferon-induced transmembrane protein; Region: CD225; pfam04505 291331000944 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 291331000945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 291331000946 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 291331000947 putative acyl-acceptor binding pocket; other site 291331000948 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 291331000949 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 291331000950 Predicted ATPase [General function prediction only]; Region: COG4637 291331000951 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331000952 Walker A/P-loop; other site 291331000953 ATP binding site [chemical binding]; other site 291331000954 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 291331000955 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 291331000956 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 291331000957 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331000958 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 291331000959 Predicted ATPase [General function prediction only]; Region: COG4637 291331000960 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331000961 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 291331000962 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 291331000963 purine monophosphate binding site [chemical binding]; other site 291331000964 dimer interface [polypeptide binding]; other site 291331000965 putative catalytic residues [active] 291331000966 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 291331000967 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 291331000968 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 291331000969 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331000970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331000971 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331000972 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331000973 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331000974 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 291331000975 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 291331000976 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 291331000977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 291331000978 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 291331000979 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 291331000980 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 291331000981 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 291331000982 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331000983 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 291331000984 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 291331000985 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 291331000986 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 291331000987 carboxyltransferase (CT) interaction site; other site 291331000988 biotinylation site [posttranslational modification]; other site 291331000989 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 291331000990 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 291331000991 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 291331000992 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 291331000993 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 291331000994 DsbD alpha interface [polypeptide binding]; other site 291331000995 catalytic residues [active] 291331000996 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 291331000997 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331000998 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331000999 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331001000 Transposase; Region: DEDD_Tnp_IS110; pfam01548 291331001001 primosome assembly protein PriA; Validated; Region: PRK05580 291331001002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 291331001003 ATP binding site [chemical binding]; other site 291331001004 putative Mg++ binding site [ion binding]; other site 291331001005 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331001006 nucleotide binding region [chemical binding]; other site 291331001007 ATP-binding site [chemical binding]; other site 291331001008 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 291331001009 multidrug efflux protein; Reviewed; Region: PRK01766 291331001010 MatE; Region: MatE; pfam01554 291331001011 MatE; Region: MatE; pfam01554 291331001012 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 291331001013 tandem repeat interface [polypeptide binding]; other site 291331001014 oligomer interface [polypeptide binding]; other site 291331001015 active site residues [active] 291331001016 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 291331001017 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 291331001018 tandem repeat interface [polypeptide binding]; other site 291331001019 oligomer interface [polypeptide binding]; other site 291331001020 active site residues [active] 291331001021 tropinone reductase; Provisional; Region: PRK09242 291331001022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331001023 NAD(P) binding site [chemical binding]; other site 291331001024 active site 291331001025 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 291331001026 DNA topoisomerase I; Provisional; Region: PRK08780 291331001027 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 291331001028 active site 291331001029 interdomain interaction site; other site 291331001030 putative metal-binding site [ion binding]; other site 291331001031 nucleotide binding site [chemical binding]; other site 291331001032 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 291331001033 domain I; other site 291331001034 DNA binding groove [nucleotide binding] 291331001035 phosphate binding site [ion binding]; other site 291331001036 domain II; other site 291331001037 domain III; other site 291331001038 nucleotide binding site [chemical binding]; other site 291331001039 catalytic site [active] 291331001040 domain IV; other site 291331001041 RDD family; Region: RDD; cl00746 291331001042 putative major pilin subunit; Provisional; Region: PRK10574 291331001043 Pilin (bacterial filament); Region: Pilin; pfam00114 291331001044 Protein of unknown function (DUF494); Region: DUF494; cl01103 291331001045 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 291331001046 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 291331001047 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 291331001048 putative peptidoglycan binding site; other site 291331001049 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 291331001050 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 291331001051 active site 291331001052 catalytic residues [active] 291331001053 metal binding site [ion binding]; metal-binding site 291331001054 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 291331001055 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 291331001056 putative active site [active] 291331001057 substrate binding site [chemical binding]; other site 291331001058 putative cosubstrate binding site; other site 291331001059 catalytic site [active] 291331001060 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 291331001061 substrate binding site [chemical binding]; other site 291331001062 16S rRNA methyltransferase B; Provisional; Region: PRK10901 291331001063 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 291331001064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331001065 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 291331001066 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 291331001067 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 291331001068 O-Antigen ligase; Region: Wzy_C; cl04850 291331001069 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 291331001070 putative metal binding site [ion binding]; other site 291331001071 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 291331001072 Predicted membrane protein [Function unknown]; Region: COG3428 291331001073 Bacterial membrane flanked domain; Region: DUF304; cl01348 291331001074 Bacterial membrane flanked domain; Region: DUF304; cl01348 291331001075 Bacterial membrane flanked domain; Region: DUF304; cl01348 291331001076 Bacterial membrane flanked domain; Region: DUF304; cl01348 291331001077 GTP cyclohydrolase; Provisional; Region: PRK08815 291331001078 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 291331001079 dimerization interface [polypeptide binding]; other site 291331001080 active site 291331001081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331001082 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 291331001083 putative acyl-acceptor binding pocket; other site 291331001084 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 291331001085 putative active site [active] 291331001086 dimerization interface [polypeptide binding]; other site 291331001087 putative tRNAtyr binding site [nucleotide binding]; other site 291331001088 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 291331001089 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 291331001090 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 291331001091 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 291331001092 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 291331001093 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 291331001094 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 291331001095 DNA binding residues [nucleotide binding] 291331001096 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 291331001097 Phage integrase family; Region: Phage_integrase; pfam00589 291331001098 DNA binding site [nucleotide binding] 291331001099 Int/Topo IB signature motif; other site 291331001100 active site 291331001101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001102 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331001103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001104 Type IV secretion system proteins; Region: T4SS; cl06849 291331001105 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 291331001106 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 291331001107 additional DNA contacts [nucleotide binding]; other site 291331001108 mismatch recognition site; other site 291331001109 active site 291331001110 zinc binding site [ion binding]; other site 291331001111 DNA intercalation site [nucleotide binding]; other site 291331001112 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 291331001113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331001114 cofactor binding site; other site 291331001115 DNA binding site [nucleotide binding] 291331001116 substrate interaction site [chemical binding]; other site 291331001117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331001118 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 291331001119 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 291331001120 DNA binding site [nucleotide binding] 291331001121 Int/Topo IB signature motif; other site 291331001122 active site 291331001123 Parvovirus non-structural protein NS1; Region: Parvo_NS1; pfam01057 291331001124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331001125 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331001126 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331001127 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331001128 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331001129 C2 domain; Region: C2; cl14603 291331001131 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 291331001132 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 291331001133 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 291331001134 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331001135 N-terminal plug; other site 291331001136 ligand-binding site [chemical binding]; other site 291331001137 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 291331001138 hypothetical protein; Provisional; Region: PRK09040 291331001139 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 291331001140 ligand binding site [chemical binding]; other site 291331001141 Domain of unknown function (DUF802); Region: DUF802; pfam05650 291331001142 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 291331001143 Flagellin N-methylase; Region: FliB; cl00497 291331001144 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 291331001145 NAD(P) binding site [chemical binding]; other site 291331001146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001148 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 291331001149 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 291331001150 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 291331001151 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 291331001152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331001153 active site 291331001154 phosphorylation site [posttranslational modification] 291331001155 intermolecular recognition site; other site 291331001156 dimerization interface [polypeptide binding]; other site 291331001157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331001158 Walker A motif; other site 291331001159 ATP binding site [chemical binding]; other site 291331001160 Walker B motif; other site 291331001161 arginine finger; other site 291331001162 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 291331001163 CheB methylesterase; Region: CheB_methylest; pfam01339 291331001164 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 291331001165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331001166 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331001167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 291331001168 Integrase core domain; Region: rve; cl01316 291331001169 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331001170 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 291331001171 FAD dependent oxidoreductase; Region: DAO; pfam01266 291331001173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331001174 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331001175 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 291331001177 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 291331001178 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 291331001179 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 291331001180 active site 291331001181 Zn binding site [ion binding]; other site 291331001182 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 291331001183 active site 291331001184 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 291331001185 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 291331001186 active site 291331001187 catalytic tetrad [active] 291331001188 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 291331001189 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 291331001190 putative active site [active] 291331001191 metal binding site [ion binding]; metal-binding site 291331001192 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 291331001193 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 291331001194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 291331001195 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 291331001196 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 291331001197 Fasciclin domain; Region: Fasciclin; cl02663 291331001198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331001199 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331001200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331001201 Integrase core domain; Region: rve; cl01316 291331001202 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 291331001203 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 291331001204 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 291331001205 Walker A/P-loop; other site 291331001206 ATP binding site [chemical binding]; other site 291331001207 Q-loop/lid; other site 291331001208 ABC transporter signature motif; other site 291331001209 Walker B; other site 291331001210 D-loop; other site 291331001211 H-loop/switch region; other site 291331001212 ABC-2 type transporter; Region: ABC2_membrane; cl11417 291331001213 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 291331001214 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 291331001215 active site 291331001216 catalytic triad [active] 291331001217 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 291331001218 YadA-like C-terminal region; Region: YadA; pfam03895 291331001219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331001220 dimer interface [polypeptide binding]; other site 291331001221 phosphorylation site [posttranslational modification] 291331001222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331001223 ATP binding site [chemical binding]; other site 291331001224 Mg2+ binding site [ion binding]; other site 291331001225 G-X-G motif; other site 291331001226 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 291331001227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331001228 active site 291331001229 phosphorylation site [posttranslational modification] 291331001230 intermolecular recognition site; other site 291331001231 dimerization interface [polypeptide binding]; other site 291331001232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 291331001233 DNA binding site [nucleotide binding] 291331001234 flagellar motor protein MotB; Validated; Region: motB; PRK09041 291331001235 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 291331001236 ligand binding site [chemical binding]; other site 291331001237 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 291331001238 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 291331001239 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 291331001240 SelR domain; Region: SelR; cl00369 291331001241 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 291331001242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331001243 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 291331001244 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 291331001245 alanine racemase; Reviewed; Region: alr; PRK00053 291331001246 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 291331001247 active site 291331001248 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 291331001249 substrate binding site [chemical binding]; other site 291331001250 catalytic residues [active] 291331001251 dimer interface [polypeptide binding]; other site 291331001252 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 291331001253 PAS domain S-box; Region: sensory_box; TIGR00229 291331001254 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 291331001255 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 291331001256 putative active site [active] 291331001257 heme pocket [chemical binding]; other site 291331001258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331001259 dimer interface [polypeptide binding]; other site 291331001260 phosphorylation site [posttranslational modification] 291331001261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331001262 ATP binding site [chemical binding]; other site 291331001263 Mg2+ binding site [ion binding]; other site 291331001264 G-X-G motif; other site 291331001265 Response regulator receiver domain; Region: Response_reg; pfam00072 291331001266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331001267 active site 291331001268 phosphorylation site [posttranslational modification] 291331001269 intermolecular recognition site; other site 291331001270 dimerization interface [polypeptide binding]; other site 291331001271 Protein of unknown function (DUF3247); Region: DUF3247; pfam11607 291331001272 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 291331001273 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 291331001274 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 291331001275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331001276 S-adenosylmethionine binding site [chemical binding]; other site 291331001277 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 291331001278 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 291331001279 active site 291331001280 uracil binding [chemical binding]; other site 291331001281 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 291331001282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 291331001283 motif II; other site 291331001284 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 291331001285 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 291331001286 Protein of unknown function (DUF520); Region: DUF520; cl00723 291331001287 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 291331001288 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 291331001289 Walker A/P-loop; other site 291331001290 ATP binding site [chemical binding]; other site 291331001291 Q-loop/lid; other site 291331001292 ABC transporter signature motif; other site 291331001293 Walker B; other site 291331001294 D-loop; other site 291331001295 H-loop/switch region; other site 291331001296 NIL domain; Region: NIL; pfam09383 291331001297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 291331001298 dimer interface [polypeptide binding]; other site 291331001299 conserved gate region; other site 291331001300 ABC-ATPase subunit interface; other site 291331001301 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331001302 Surface antigen; Region: Surface_Ag_2; cl01155 291331001303 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 291331001304 Protein of unknown function (DUF2884); Region: DUF2884; cl08135 291331001305 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 291331001306 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 291331001307 E3 interaction surface; other site 291331001308 lipoyl attachment site [posttranslational modification]; other site 291331001309 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 291331001310 E3 interaction surface; other site 291331001311 lipoyl attachment site [posttranslational modification]; other site 291331001312 e3 binding domain; Region: E3_binding; pfam02817 291331001313 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 291331001314 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 291331001315 E3 interaction surface; other site 291331001316 lipoyl attachment site [posttranslational modification]; other site 291331001317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331001318 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 291331001319 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331001320 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 291331001321 ATP synthase A chain; Region: ATP-synt_A; cl00413 291331001322 ATP synthase subunit C; Region: ATP-synt_C; cl00466 291331001323 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 291331001324 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 291331001325 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 291331001326 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 291331001327 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 291331001328 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 291331001329 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 291331001330 beta subunit interaction interface [polypeptide binding]; other site 291331001331 Walker A motif; other site 291331001332 ATP binding site [chemical binding]; other site 291331001333 Walker B motif; other site 291331001334 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 291331001335 ATP synthase; Region: ATP-synt; cl00365 291331001336 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 291331001337 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 291331001338 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 291331001339 alpha subunit interaction interface [polypeptide binding]; other site 291331001340 Walker A motif; other site 291331001341 ATP binding site [chemical binding]; other site 291331001342 Walker B motif; other site 291331001343 inhibitor binding site; inhibition site 291331001344 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 291331001345 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 291331001346 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 291331001347 Chorismate mutase type II; Region: CM_2; cl00693 291331001348 GtrA-like protein; Region: GtrA; cl00971 291331001349 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 291331001350 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 291331001351 Substrate binding site [chemical binding]; other site 291331001352 Mg++ binding site [ion binding]; other site 291331001353 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 291331001354 active site 291331001355 substrate binding site [chemical binding]; other site 291331001356 CoA binding site [chemical binding]; other site 291331001357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331001358 ATP binding site [chemical binding]; other site 291331001359 G-X-G motif; other site 291331001360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001361 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331001362 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331001363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331001365 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331001366 Walker A/P-loop; other site 291331001367 ATP binding site [chemical binding]; other site 291331001368 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 291331001369 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 291331001370 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 291331001371 glutaminase active site [active] 291331001372 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 291331001373 dimer interface [polypeptide binding]; other site 291331001374 active site 291331001375 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 291331001376 dimer interface [polypeptide binding]; other site 291331001377 active site 291331001378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001379 Transposase domain (DUF772); Region: DUF772; cl12084 291331001380 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331001381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331001383 Integrase core domain; Region: rve; cl01316 291331001384 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 291331001385 dimer interface [polypeptide binding]; other site 291331001386 active site 291331001387 metal binding site [ion binding]; metal-binding site 291331001388 glutathione binding site [chemical binding]; other site 291331001389 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 291331001390 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 291331001391 Multicopper oxidase; Region: Cu-oxidase; cl14658 291331001392 Multicopper oxidase; Region: Cu-oxidase; cl14658 291331001393 Multicopper oxidase; Region: Cu-oxidase; cl14658 291331001394 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 291331001395 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 291331001396 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331001397 catalytic residue [active] 291331001398 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 291331001399 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 291331001400 active site 291331001401 Zn binding site [ion binding]; other site 291331001402 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 291331001403 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 291331001404 dimer interface [polypeptide binding]; other site 291331001405 active site 291331001406 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 291331001407 dimer interface [polypeptide binding]; other site 291331001408 active site 1 [active] 291331001409 active site 2 [active] 291331001410 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 291331001411 active site 291331001412 DNA polymerase IV; Validated; Region: PRK02406 291331001413 DNA binding site [nucleotide binding] 291331001414 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 291331001415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 291331001416 motif II; other site 291331001417 TfoX N-terminal domain; Region: TfoX_N; cl01167 291331001418 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 291331001419 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 291331001420 active site 291331001421 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 291331001422 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 291331001423 ATP binding site [chemical binding]; other site 291331001424 Mg++ binding site [ion binding]; other site 291331001425 motif III; other site 291331001426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331001427 nucleotide binding region [chemical binding]; other site 291331001428 ATP-binding site [chemical binding]; other site 291331001429 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 291331001430 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 291331001431 maleylacetoacetate isomerase; Region: maiA; TIGR01262 291331001432 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 291331001433 C-terminal domain interface [polypeptide binding]; other site 291331001434 GSH binding site (G-site) [chemical binding]; other site 291331001435 putative dimer interface [polypeptide binding]; other site 291331001436 GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191 291331001437 dimer interface [polypeptide binding]; other site 291331001438 N-terminal domain interface [polypeptide binding]; other site 291331001439 putative maleylacetoacetate (MAA) substrate binding site (H site); other site 291331001440 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 291331001441 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331001442 ATP binding site [chemical binding]; other site 291331001443 Walker B motif; other site 291331001444 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 291331001445 Protein of unknown function (DUF465); Region: DUF465; cl01070 291331001446 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 291331001447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331001448 dimer interface [polypeptide binding]; other site 291331001449 FOG: CBS domain [General function prediction only]; Region: COG0517 291331001450 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as...; Region: CBS_pair_PALP_assoc2; cd04609 291331001451 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 291331001452 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 291331001453 homodimer interface [polypeptide binding]; other site 291331001454 substrate-cofactor binding pocket; other site 291331001455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331001456 catalytic residue [active] 291331001457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331001458 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 291331001459 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 291331001460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 291331001461 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 291331001462 active site 291331001463 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 291331001464 Transposase, Mutator family; Region: Transposase_mut; pfam00872 291331001465 MULE transposase domain; Region: MULE; pfam10551 291331001466 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 291331001467 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 291331001468 Walker A/P-loop; other site 291331001469 ATP binding site [chemical binding]; other site 291331001470 Q-loop/lid; other site 291331001471 ABC transporter signature motif; other site 291331001472 Walker B; other site 291331001473 D-loop; other site 291331001474 H-loop/switch region; other site 291331001475 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 291331001476 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 291331001477 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 291331001478 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 291331001479 Ligand binding site [chemical binding]; other site 291331001480 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 291331001481 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 291331001482 NAD binding site [chemical binding]; other site 291331001483 substrate binding site [chemical binding]; other site 291331001484 homodimer interface [polypeptide binding]; other site 291331001485 active site 291331001486 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 291331001487 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 291331001488 substrate binding site [chemical binding]; other site 291331001489 tetramer interface [polypeptide binding]; other site 291331001490 Cupin domain; Region: Cupin_2; cl09118 291331001491 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 291331001492 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 291331001493 NADP binding site [chemical binding]; other site 291331001494 active site 291331001495 putative substrate binding site [chemical binding]; other site 291331001496 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 291331001497 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 291331001498 Substrate binding site [chemical binding]; other site 291331001499 Cupin domain; Region: Cupin_2; cl09118 291331001500 phosphomannomutase CpsG; Provisional; Region: PRK15414 291331001501 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 291331001502 active site 291331001503 substrate binding site [chemical binding]; other site 291331001504 metal binding site [ion binding]; metal-binding site 291331001505 Coenzyme A transferase; Region: CoA_trans; cl00773 291331001506 Coenzyme A transferase; Region: CoA_trans; cl00773 291331001507 Rhamnan synthesis protein F; Region: RgpF; cl01529 291331001508 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 291331001509 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331001510 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 291331001511 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 291331001512 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 291331001513 Protein of unknown function (DUF330); Region: DUF330; cl01135 291331001514 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 291331001515 mce related protein; Region: MCE; cl03606 291331001516 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 291331001517 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331001518 Walker A/P-loop; other site 291331001519 ATP binding site [chemical binding]; other site 291331001520 Q-loop/lid; other site 291331001521 ABC transporter signature motif; other site 291331001522 Walker B; other site 291331001523 D-loop; other site 291331001524 H-loop/switch region; other site 291331001525 Domain of unknown function DUF140; Region: DUF140; cl00510 291331001526 Uncharacterized conserved protein [Function unknown]; Region: COG2966 291331001527 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 291331001528 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 291331001529 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 291331001530 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 291331001531 prolyl-tRNA synthetase; Provisional; Region: PRK09194 291331001532 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 291331001533 dimer interface [polypeptide binding]; other site 291331001534 motif 1; other site 291331001535 active site 291331001536 motif 2; other site 291331001537 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 291331001538 putative deacylase active site [active] 291331001539 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 291331001540 active site 291331001541 motif 3; other site 291331001542 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 291331001543 anticodon binding site; other site 291331001544 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 291331001545 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 291331001546 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 291331001547 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 291331001548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 291331001549 Coenzyme A binding pocket [chemical binding]; other site 291331001550 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331001551 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331001553 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331001554 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331001555 lytic murein transglycosylase; Provisional; Region: PRK11619 291331001556 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 291331001557 N-acetyl-D-glucosamine binding site [chemical binding]; other site 291331001558 catalytic residue [active] 291331001559 Pectate lyase; Region: Pec_lyase_C; cl01593 291331001560 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331001561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001562 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331001563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001564 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331001565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331001566 putative transposase OrfB; Reviewed; Region: PHA02517 291331001567 Integrase core domain; Region: rve; cl01316 291331001568 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 291331001569 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 291331001570 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 291331001571 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291331001572 active site 291331001573 HIGH motif; other site 291331001574 nucleotide binding site [chemical binding]; other site 291331001575 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 291331001576 active site 291331001577 KMSKS motif; other site 291331001578 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 291331001579 tRNA binding surface [nucleotide binding]; other site 291331001580 anticodon binding site; other site 291331001581 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 291331001582 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 291331001583 multifunctional aminopeptidase A; Provisional; Region: PRK00913 291331001584 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 291331001585 interface (dimer of trimers) [polypeptide binding]; other site 291331001586 Substrate-binding/catalytic site; other site 291331001587 Zn-binding sites [ion binding]; other site 291331001588 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 291331001589 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 291331001590 RDD family; Region: RDD; cl00746 291331001591 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 291331001592 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 291331001593 Int/Topo IB signature motif; other site 291331001594 active site 291331001595 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 291331001596 dimerization domain [polypeptide binding]; other site 291331001597 dimer interface [polypeptide binding]; other site 291331001598 catalytic residues [active] 291331001599 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 291331001600 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal...; Region: PurM-like; cl10019 291331001601 dimerization interface [polypeptide binding]; other site 291331001602 ATP binding site [chemical binding]; other site 291331001603 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 291331001604 dimerization interface [polypeptide binding]; other site 291331001605 ATP binding site [chemical binding]; other site 291331001606 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 291331001607 putative active site [active] 291331001608 catalytic triad [active] 291331001609 YadA-like C-terminal region; Region: YadA; pfam03895 291331001610 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 291331001611 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 291331001612 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 291331001613 Walker A motif; other site 291331001614 ATP binding site [chemical binding]; other site 291331001615 Walker B motif; other site 291331001616 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 291331001617 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 291331001618 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 291331001619 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 291331001620 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 291331001621 general secretion pathway protein J; Validated; Region: PRK08808 291331001622 General secretion pathway protein K; Region: GspK; pfam03934 291331001623 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 291331001624 General secretion pathway protein M; Region: GspM_II; pfam10741 291331001625 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 291331001626 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 291331001627 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 291331001628 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 291331001629 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 291331001630 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 291331001631 transcriptional regulator protein; Region: phnR; TIGR03337 291331001632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 291331001633 DNA-binding site [nucleotide binding]; DNA binding site 291331001634 UTRA domain; Region: UTRA; cl06649 291331001635 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 291331001636 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 291331001637 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331001638 N-terminal plug; other site 291331001639 ligand-binding site [chemical binding]; other site 291331001640 Phosphotransferase enzyme family; Region: APH; pfam01636 291331001641 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 291331001642 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 291331001643 Probable Catalytic site [active] 291331001644 metal binding site [ion binding]; metal-binding site 291331001645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331001646 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 291331001647 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 291331001648 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 291331001649 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 291331001650 CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863 291331001651 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 291331001652 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 291331001653 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 291331001654 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 291331001655 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 291331001656 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 291331001657 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331001658 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331001659 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331001660 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 291331001661 active site 291331001662 dimer interface [polypeptide binding]; other site 291331001663 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 291331001664 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 291331001665 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 291331001666 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 291331001667 dimer interface [polypeptide binding]; other site 291331001668 active site 291331001669 CoA binding pocket [chemical binding]; other site 291331001670 MEKHLA domain; Region: MEKHLA; pfam08670 291331001671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 291331001672 putative active site [active] 291331001673 heme pocket [chemical binding]; other site 291331001674 Acyl transferase domain; Region: Acyl_transf_1; cl08282 291331001675 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 291331001676 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 291331001677 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 291331001678 NAD(P) binding site [chemical binding]; other site 291331001679 homotetramer interface [polypeptide binding]; other site 291331001680 homodimer interface [polypeptide binding]; other site 291331001681 active site 291331001682 Phosphopantetheine attachment site; Region: PP-binding; cl09936 291331001683 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 291331001684 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 291331001685 dimer interface [polypeptide binding]; other site 291331001686 active site 291331001687 hypothetical protein; Validated; Region: PRK09070 291331001688 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 291331001689 chorismate binding enzyme; Region: Chorismate_bind; cl10555 291331001690 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 291331001691 dimerization interface [polypeptide binding]; other site 291331001692 DNA polymerase III subunit delta'; Validated; Region: PRK08769 291331001693 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331001694 PilZ domain; Region: PilZ; cl01260 291331001695 DUF based on B. Theta Gene description; Region: DUF3876; pfam12992 291331001696 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 291331001697 Propionate catabolism activator; Region: PrpR_N; pfam06506 291331001698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331001699 Walker A motif; other site 291331001700 ATP binding site [chemical binding]; other site 291331001701 Walker B motif; other site 291331001702 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 291331001703 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 291331001704 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 291331001705 tetramer interface [polypeptide binding]; other site 291331001706 active site 291331001707 Mg2+/Mn2+ binding site [ion binding]; other site 291331001708 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 291331001709 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (...; Region: Ec2MCS_like_1; cd06117 291331001710 dimer interface [polypeptide binding]; other site 291331001711 active site 291331001712 citrylCoA binding site [chemical binding]; other site 291331001713 oxalacetate/citrate binding site [chemical binding]; other site 291331001714 coenzyme A binding site [chemical binding]; other site 291331001715 catalytic triad [active] 291331001716 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 291331001717 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 291331001718 substrate binding site [chemical binding]; other site 291331001719 ligand binding site [chemical binding]; other site 291331001720 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 291331001721 substrate binding site [chemical binding]; other site 291331001722 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 291331001723 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 291331001724 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331001725 N-terminal plug; other site 291331001726 ligand-binding site [chemical binding]; other site 291331001727 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 291331001728 active site 291331001729 Transposase IS200 like; Region: Y1_Tnp; cl00848 291331001730 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 291331001731 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331001732 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331001733 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331001734 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 291331001735 putative active site [active] 291331001736 catalytic site [active] 291331001737 putative metal binding site [ion binding]; other site 291331001738 oligomer interface [polypeptide binding]; other site 291331001739 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331001740 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331001741 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331001742 Integrase core domain; Region: rve; cl01316 291331001743 Ferritin-like domain; Region: Ferritin; pfam00210 291331001744 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 291331001745 dinuclear metal binding motif [ion binding]; other site 291331001746 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 291331001747 catalytic triad [active] 291331001748 dimer interface [polypeptide binding]; other site 291331001749 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 291331001750 putative dimer interface [polypeptide binding]; other site 291331001751 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 291331001752 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 291331001753 HSP70 interaction site [polypeptide binding]; other site 291331001754 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 291331001755 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 291331001756 Response regulator receiver domain; Region: Response_reg; pfam00072 291331001757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331001758 active site 291331001759 phosphorylation site [posttranslational modification] 291331001760 intermolecular recognition site; other site 291331001761 dimerization interface [polypeptide binding]; other site 291331001762 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 291331001763 HflK protein; Region: hflK; TIGR01933 291331001764 FtsH protease regulator HflC; Provisional; Region: PRK11029 291331001765 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 291331001766 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275 291331001767 adenylosuccinate synthetase; Provisional; Region: PRK01117 291331001768 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 291331001769 GDP-binding site [chemical binding]; other site 291331001770 ACT binding site; other site 291331001771 IMP binding site; other site 291331001772 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 291331001773 Zn binding site [ion binding]; other site 291331001774 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331001775 HSP20-like domain of unknown function (DUF1813); Region: DUF1813; cl07446 291331001776 Transposase domain (DUF772); Region: DUF772; cl12084 291331001777 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331001778 Zinc-finger domain; Region: zf-CHCC; cl01821 291331001779 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 291331001780 putative ADP-binding pocket [chemical binding]; other site 291331001781 O-Antigen ligase; Region: Wzy_C; cl04850 291331001782 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 291331001783 putative acyl-acceptor binding pocket; other site 291331001784 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 291331001785 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 291331001786 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 291331001787 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 291331001788 Outer membrane efflux protein; Region: OEP; pfam02321 291331001789 Outer membrane efflux protein; Region: OEP; pfam02321 291331001790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331001791 S-adenosylmethionine binding site [chemical binding]; other site 291331001792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 291331001793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 291331001794 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 291331001795 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331001796 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331001798 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 291331001799 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331001800 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 291331001801 dimerization interface [polypeptide binding]; other site 291331001802 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 291331001803 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 291331001804 substrate binding site [chemical binding]; other site 291331001805 ligand binding site [chemical binding]; other site 291331001806 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 291331001807 substrate binding site [chemical binding]; other site 291331001808 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 291331001809 isocitrate dehydrogenase; Validated; Region: PRK06451 291331001810 2-isopropylmalate synthase; Validated; Region: PRK00915 291331001811 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 291331001812 active site 291331001813 catalytic residues [active] 291331001814 metal binding site [ion binding]; metal-binding site 291331001815 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 291331001817 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 291331001818 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 291331001819 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 291331001820 PYR/PP interface [polypeptide binding]; other site 291331001821 dimer interface [polypeptide binding]; other site 291331001822 TPP binding site [chemical binding]; other site 291331001823 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 291331001824 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 291331001825 TPP-binding site [chemical binding]; other site 291331001826 dimer interface [polypeptide binding]; other site 291331001827 ketol-acid reductoisomerase; Provisional; Region: PRK05479 291331001828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331001829 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 291331001830 ThiC family; Region: ThiC; cl08031 291331001831 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331001832 DNA binding site [nucleotide binding] 291331001833 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 291331001834 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 291331001835 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 291331001836 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331001837 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331001838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331001839 active site 291331001840 phosphorylation site [posttranslational modification] 291331001841 intermolecular recognition site; other site 291331001842 dimerization interface [polypeptide binding]; other site 291331001843 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 291331001844 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 291331001845 dimer interface [polypeptide binding]; other site 291331001846 substrate binding site [chemical binding]; other site 291331001847 metal binding sites [ion binding]; metal-binding site 291331001848 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 291331001849 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331001850 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331001851 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 291331001852 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331001853 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331001854 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331001855 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 291331001856 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 291331001857 active site 291331001858 ADP/pyrophosphate binding site [chemical binding]; other site 291331001859 dimerization interface [polypeptide binding]; other site 291331001860 allosteric effector site; other site 291331001861 fructose-1,6-bisphosphate binding site; other site 291331001862 adenylate kinase; Reviewed; Region: adk; PRK00279 291331001863 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 291331001864 AMP-binding site [chemical binding]; other site 291331001865 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 291331001866 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 291331001867 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 291331001868 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 291331001869 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 291331001870 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 291331001871 Found in ATP-dependent protease La (LON); Region: LON; cl01056 291331001872 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 291331001873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001875 glutathionine S-transferase; Provisional; Region: PRK10542 291331001876 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 291331001877 C-terminal domain interface [polypeptide binding]; other site 291331001878 GSH binding site (G-site) [chemical binding]; other site 291331001879 dimer interface [polypeptide binding]; other site 291331001880 GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188 291331001881 dimer interface [polypeptide binding]; other site 291331001882 N-terminal domain interface [polypeptide binding]; other site 291331001883 substrate binding pocket (H-site) [chemical binding]; other site 291331001884 malate dehydrogenase; Provisional; Region: PRK05442 291331001885 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 291331001886 NAD(P) binding site [chemical binding]; other site 291331001887 dimer interface [polypeptide binding]; other site 291331001888 malate binding site [chemical binding]; other site 291331001889 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 291331001890 active site 291331001891 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 291331001892 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 291331001893 G1 box; other site 291331001894 putative GEF interaction site [polypeptide binding]; other site 291331001895 GTP/Mg2+ binding site [chemical binding]; other site 291331001896 Switch I region; other site 291331001897 G2 box; other site 291331001898 G3 box; other site 291331001899 Switch II region; other site 291331001900 G4 box; other site 291331001901 G5 box; other site 291331001902 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 291331001903 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 291331001904 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 291331001905 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 291331001906 Mechanosensitive ion channel; Region: MS_channel; pfam00924 291331001907 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 291331001908 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 291331001909 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331001910 N-terminal plug; other site 291331001911 ligand-binding site [chemical binding]; other site 291331001912 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 291331001913 Transposase domain (DUF772); Region: DUF772; cl12084 291331001914 putative transposase OrfB; Reviewed; Region: PHA02517 291331001915 Integrase core domain; Region: rve; cl01316 291331001916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331001917 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331001918 Equine arteritis virus serine endopeptidase S32; Region: Peptidase_S32; pfam05579 291331001919 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 291331001920 Integrase core domain; Region: rve; cl01316 291331001921 putative transposase OrfB; Reviewed; Region: PHA02517 291331001922 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331001923 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331001924 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331001925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331001926 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331001927 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331001928 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 291331001929 active site 291331001930 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331001931 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331001932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001933 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331001934 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331001936 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 291331001937 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 291331001938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001940 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 291331001941 putative active site [active] 291331001942 catalytic site [active] 291331001943 putative metal binding site [ion binding]; other site 291331001944 oligomer interface [polypeptide binding]; other site 291331001945 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331001946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001948 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331001949 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331001950 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 291331001951 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473 291331001952 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331001953 Integrase core domain; Region: rve; cl01316 291331001954 Integrase core domain; Region: rve; cl01316 291331001955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331001956 trigger factor; Provisional; Region: tig; PRK01490 291331001957 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 291331001958 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 291331001959 oligomer interface [polypeptide binding]; other site 291331001960 active site residues [active] 291331001961 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 291331001962 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 291331001963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331001964 Walker A motif; other site 291331001965 ATP binding site [chemical binding]; other site 291331001966 Walker B motif; other site 291331001967 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 291331001968 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 291331001969 Found in ATP-dependent protease La (LON); Region: LON; cl01056 291331001970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331001971 Walker A motif; other site 291331001972 ATP binding site [chemical binding]; other site 291331001973 Walker B motif; other site 291331001974 arginine finger; other site 291331001975 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 291331001976 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 291331001977 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 291331001978 IHF dimer interface [polypeptide binding]; other site 291331001979 IHF - DNA interface [nucleotide binding]; other site 291331001980 periplasmic folding chaperone; Provisional; Region: PRK10788 291331001981 PPIC-type PPIASE domain; Region: Rotamase; cl08278 291331001982 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 291331001983 N-acetyl-D-glucosamine binding site [chemical binding]; other site 291331001984 catalytic residue [active] 291331001985 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 291331001986 putative peptidoglycan binding site; other site 291331001987 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 291331001988 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 291331001989 RNA/DNA hybrid binding site [nucleotide binding]; other site 291331001990 active site 291331001991 Proteobacterial; Region: dnaQ_proteo; TIGR01406 291331001992 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 291331001993 active site 291331001994 substrate binding site [chemical binding]; other site 291331001995 catalytic site [active] 291331001996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331001997 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 291331001998 Protein phosphatase 2C; Region: PP2C; pfam00481 291331001999 Active site [active] 291331002000 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 291331002001 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 291331002002 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331002003 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331002004 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 291331002005 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 291331002006 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 291331002007 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 291331002008 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 291331002009 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 291331002010 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331002011 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331002012 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 291331002013 Phage integrase family; Region: Phage_integrase; pfam00589 291331002014 DNA binding site [nucleotide binding] 291331002015 Int/Topo IB signature motif; other site 291331002016 active site 291331002017 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 291331002018 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 291331002019 putative active site [active] 291331002020 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 291331002021 ATP binding site [chemical binding]; other site 291331002022 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 291331002023 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 291331002024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 291331002025 FeS/SAM binding site; other site 291331002026 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 291331002027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 291331002028 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 291331002029 trimer interface [polypeptide binding]; other site 291331002030 dimer interface [polypeptide binding]; other site 291331002031 putative active site [active] 291331002032 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 291331002033 MoaE interaction surface [polypeptide binding]; other site 291331002034 MoeB interaction surface [polypeptide binding]; other site 291331002035 thiocarboxylated glycine; other site 291331002036 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 291331002037 MoaE homodimer interface [polypeptide binding]; other site 291331002038 MoaD interaction [polypeptide binding]; other site 291331002039 active site residues [active] 291331002040 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 291331002041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331002042 Walker A motif; other site 291331002043 ATP binding site [chemical binding]; other site 291331002044 Walker B motif; other site 291331002045 arginine finger; other site 291331002046 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 291331002047 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 291331002048 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 291331002049 recombination protein RecR; Reviewed; Region: recR; PRK00076 291331002050 RecR protein; Region: RecR; pfam02132 291331002051 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 291331002052 putative active site [active] 291331002053 putative metal-binding site [ion binding]; other site 291331002054 tetramer interface [polypeptide binding]; other site 291331002055 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 291331002056 nucleotide binding site/active site [active] 291331002057 HIT family signature motif; other site 291331002058 catalytic residue [active] 291331002059 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 291331002060 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 291331002061 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 291331002062 Protein of unknown function DUF58; Region: DUF58; pfam01882 291331002063 MoxR-like ATPases [General function prediction only]; Region: COG0714 291331002064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331002065 Walker A motif; other site 291331002066 ATP binding site [chemical binding]; other site 291331002067 Walker B motif; other site 291331002068 arginine finger; other site 291331002069 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 291331002070 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 291331002071 active site 291331002072 catalytic residues [active] 291331002073 metal binding site [ion binding]; metal-binding site 291331002074 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 291331002075 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 291331002076 Rhamnogalacturonase B, N-terminal; Region: RhgB_N; pfam09284 291331002077 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331002078 Transposase domain (DUF772); Region: DUF772; cl12084 291331002079 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 291331002080 ADP-ribose binding site [chemical binding]; other site 291331002081 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331002082 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331002083 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 291331002084 putative GSH binding site [chemical binding]; other site 291331002085 catalytic residues [active] 291331002086 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 291331002087 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 291331002088 active site residue [active] 291331002089 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 291331002090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331002091 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 291331002092 active site 291331002093 catalytic triad [active] 291331002094 oxyanion hole [active] 291331002095 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 291331002096 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 291331002097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331002098 homodimer interface [polypeptide binding]; other site 291331002099 catalytic residue [active] 291331002100 GTPase RsgA; Reviewed; Region: PRK01889 291331002101 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 291331002102 GTPase/OB domain interface [polypeptide binding]; other site 291331002103 GTPase/Zn-binding domain interface [polypeptide binding]; other site 291331002104 GTP/Mg2+ binding site [chemical binding]; other site 291331002105 G4 box; other site 291331002106 G5 box; other site 291331002107 G1 box; other site 291331002108 Switch I region; other site 291331002109 G2 box; other site 291331002110 G3 box; other site 291331002111 Switch II region; other site 291331002112 conserved hypothetical protein; Region: QEGLA; TIGR02421 291331002113 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 291331002114 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 291331002115 potential catalytic triad [active] 291331002116 conserved cys residue [active] 291331002117 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 291331002118 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 291331002119 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331002120 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331002121 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 291331002122 Ferroportin1 (FPN1); Region: FPN1; pfam06963 291331002123 Transcriptional regulators [Transcription]; Region: PurR; COG1609 291331002124 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 291331002125 DNA binding site [nucleotide binding] 291331002126 domain linker motif; other site 291331002127 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 291331002128 putative dimerization interface [polypeptide binding]; other site 291331002129 putative ligand binding site [chemical binding]; other site 291331002130 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 291331002131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331002132 NAD(P) binding site [chemical binding]; other site 291331002133 active site 291331002134 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 291331002135 Citrate transporter; Region: CitMHS; pfam03600 291331002136 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 291331002137 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 291331002138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331002139 active site 291331002140 phosphorylation site [posttranslational modification] 291331002141 intermolecular recognition site; other site 291331002142 dimerization interface [polypeptide binding]; other site 291331002143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331002144 DNA binding site [nucleotide binding] 291331002145 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 291331002146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 291331002147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331002148 ATP binding site [chemical binding]; other site 291331002149 Mg2+ binding site [ion binding]; other site 291331002150 G-X-G motif; other site 291331002152 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 291331002153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331002154 active site 291331002155 phosphorylation site [posttranslational modification] 291331002156 intermolecular recognition site; other site 291331002157 dimerization interface [polypeptide binding]; other site 291331002158 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 291331002159 DNA binding residues [nucleotide binding] 291331002160 dimerization interface [polypeptide binding]; other site 291331002161 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 291331002162 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 291331002163 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cl00470 291331002164 catalytic tetrad [active] 291331002165 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cl00470 291331002166 Transcriptional regulator [Transcription]; Region: LysR; COG0583 291331002167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331002168 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 291331002169 putative dimerization interface [polypeptide binding]; other site 291331002170 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331002171 citrate-proton symporter; Provisional; Region: PRK15075 291331002172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331002173 putative substrate translocation pore; other site 291331002174 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 291331002175 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 291331002176 PAS fold; Region: PAS_7; pfam12860 291331002177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 291331002178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331002179 ATP binding site [chemical binding]; other site 291331002180 Mg2+ binding site [ion binding]; other site 291331002181 G-X-G motif; other site 291331002182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331002183 Response regulator receiver domain; Region: Response_reg; pfam00072 291331002184 active site 291331002185 phosphorylation site [posttranslational modification] 291331002186 intermolecular recognition site; other site 291331002187 dimerization interface [polypeptide binding]; other site 291331002188 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 291331002189 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 291331002190 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 291331002191 Malic enzyme, N-terminal domain; Region: malic; pfam00390 291331002192 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 291331002193 putative NAD(P) binding site [chemical binding]; other site 291331002194 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 291331002195 putative transposase OrfB; Reviewed; Region: PHA02517 291331002196 Integrase core domain; Region: rve; cl01316 291331002197 Protein of unknown function (DUF2699); Region: DUF2699; pfam10919 291331002198 Transposase domain (DUF772); Region: DUF772; cl12084 291331002199 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 291331002200 thiamine phosphate binding site [chemical binding]; other site 291331002201 active site 291331002202 pyrophosphate binding site [ion binding]; other site 291331002203 Rubredoxin [Energy production and conversion]; Region: COG1773 291331002204 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 291331002205 iron binding site [ion binding]; other site 291331002206 Uncharacterized conserved protein [Function unknown]; Region: COG2912 291331002207 hypothetical protein; Provisional; Region: PRK10941 291331002208 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 291331002209 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 291331002210 tetramer (dimer of dimers) interface [polypeptide binding]; other site 291331002211 active site 291331002212 dimer interface [polypeptide binding]; other site 291331002213 EVE domain; Region: EVE; cl00728 291331002214 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 291331002215 Cell division protein ZapA; Region: ZapA; cl01146 291331002216 TIGR02449 family protein; Region: TIGR02449 291331002217 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 291331002218 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 291331002219 proline aminopeptidase P II; Provisional; Region: PRK10879 291331002220 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 291331002221 active site 291331002222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331002223 proline dipeptidase; Provisional; Region: PRK13607 291331002224 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 291331002225 active site 291331002226 PilZ domain; Region: PilZ; cl01260 291331002227 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 291331002228 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 291331002229 HemN family oxidoreductase; Provisional; Region: PRK05660 291331002230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 291331002231 FeS/SAM binding site; other site 291331002232 HemN C-terminal region; Region: HemN_C; pfam06969 291331002233 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 291331002234 active site 291331002235 dimerization interface [polypeptide binding]; other site 291331002236 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 291331002237 ribonuclease PH; Reviewed; Region: rph; PRK00173 291331002238 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 291331002239 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 291331002240 hypothetical protein; Provisional; Region: PRK11820 291331002241 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 291331002242 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 291331002243 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 291331002244 catalytic site [active] 291331002245 G-X2-G-X-G-K; other site 291331002246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331002247 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331002248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331002249 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 291331002250 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 291331002251 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 291331002252 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 291331002253 synthetase active site [active] 291331002254 NTP binding site [chemical binding]; other site 291331002255 metal binding site [ion binding]; metal-binding site 291331002256 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 291331002257 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 291331002258 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 291331002259 homotrimer interaction site [polypeptide binding]; other site 291331002260 putative active site [active] 291331002261 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 291331002262 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 291331002263 generic binding surface II; other site 291331002264 ssDNA binding site; other site 291331002265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 291331002266 ATP binding site [chemical binding]; other site 291331002267 putative Mg++ binding site [ion binding]; other site 291331002268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331002269 nucleotide binding region [chemical binding]; other site 291331002270 ATP-binding site [chemical binding]; other site 291331002271 nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base...; Region: nuc_hydro_CeIAG; cd02649 291331002272 active site 291331002273 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 291331002274 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 291331002275 dimer interface [polypeptide binding]; other site 291331002276 Citrate synthase; Region: Citrate_synt; pfam00285 291331002277 active site 291331002278 citrylCoA binding site [chemical binding]; other site 291331002279 NADH binding [chemical binding]; other site 291331002280 cationic pore residues; other site 291331002281 oxalacetate/citrate binding site [chemical binding]; other site 291331002282 coenzyme A binding site [chemical binding]; other site 291331002283 catalytic triad [active] 291331002284 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 291331002285 Transglycosylase; Region: Transgly; cl07896 291331002286 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 291331002287 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 291331002288 Competence protein A; Region: Competence_A; pfam11104 291331002289 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 291331002290 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 291331002291 Pilus assembly protein, PilO; Region: PilO; cl01234 291331002292 Pilus assembly protein, PilP; Region: PilP; cl01235 291331002293 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 291331002294 Secretin and TonB N terminus short domain; Region: STN; pfam07660 291331002295 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 291331002296 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 291331002297 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331002298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331002299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331002300 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331002301 Integrase core domain; Region: rve; cl01316 291331002302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331002303 MoxR-like ATPases [General function prediction only]; Region: COG0714 291331002304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331002305 Walker A motif; other site 291331002306 ATP binding site [chemical binding]; other site 291331002307 Walker B motif; other site 291331002308 arginine finger; other site 291331002309 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331002310 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 291331002311 Protein of unknown function DUF58; Region: DUF58; pfam01882 291331002312 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_BatA_type; cd01467 291331002313 metal ion-dependent adhesion site (MIDAS); other site 291331002314 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 291331002315 metal ion-dependent adhesion site (MIDAS); other site 291331002316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 291331002317 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 291331002318 transketolase; Reviewed; Region: PRK12753 291331002319 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 291331002320 TPP-binding site [chemical binding]; other site 291331002321 dimer interface [polypeptide binding]; other site 291331002322 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 291331002323 PYR/PP interface [polypeptide binding]; other site 291331002324 dimer interface [polypeptide binding]; other site 291331002325 TPP binding site [chemical binding]; other site 291331002326 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 291331002327 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331002328 Peptidase family M23; Region: Peptidase_M23; pfam01551 291331002329 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 291331002330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 291331002331 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 291331002332 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331002333 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331002334 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331002335 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 291331002336 putative active site [active] 291331002337 catalytic site [active] 291331002338 putative metal binding site [ion binding]; other site 291331002339 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 291331002340 Thermostable hemolysin; Region: T_hemolysin; pfam12261 291331002341 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 291331002342 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 291331002343 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 291331002344 heme binding pocket [chemical binding]; other site 291331002345 heme ligand [chemical binding]; other site 291331002346 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 291331002347 classical (c) SDRs; Region: SDR_c; cd05233 291331002348 NAD(P) binding site [chemical binding]; other site 291331002349 active site 291331002350 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 291331002351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331002352 active site 291331002353 phosphorylation site [posttranslational modification] 291331002354 intermolecular recognition site; other site 291331002355 dimerization interface [polypeptide binding]; other site 291331002356 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331002357 DNA binding site [nucleotide binding] 291331002358 sensor protein QseC; Provisional; Region: PRK10337 291331002359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 291331002360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331002361 ATP binding site [chemical binding]; other site 291331002362 Mg2+ binding site [ion binding]; other site 291331002363 G-X-G motif; other site 291331002364 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331002365 Peptidase family M48; Region: Peptidase_M48; cl12018 291331002366 Gram-negative bacterial tonB protein; Region: TonB; cl10048 291331002367 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331002368 Walker A/P-loop; other site 291331002369 ATP binding site [chemical binding]; other site 291331002370 Q-loop/lid; other site 291331002371 ABC transporter signature motif; other site 291331002372 Walker B; other site 291331002373 D-loop; other site 291331002374 H-loop/switch region; other site 291331002375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 291331002376 dimer interface [polypeptide binding]; other site 291331002377 conserved gate region; other site 291331002378 putative PBP binding loops; other site 291331002379 ABC-ATPase subunit interface; other site 291331002380 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331002381 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 291331002382 S1/P1 Nuclease; Region: S1-P1_nuclease; pfam02265 291331002383 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331002384 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331002385 Surface antigen; Region: Surface_Ag_2; cl01155 291331002386 Surface antigen; Region: Surface_Ag_2; cl01155 291331002387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331002388 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 291331002389 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 291331002390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331002391 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331002392 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331002393 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 291331002394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331002395 dimer interface [polypeptide binding]; other site 291331002396 phosphorylation site [posttranslational modification] 291331002397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331002398 ATP binding site [chemical binding]; other site 291331002399 Mg2+ binding site [ion binding]; other site 291331002400 G-X-G motif; other site 291331002401 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 291331002402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331002403 active site 291331002404 phosphorylation site [posttranslational modification] 291331002405 intermolecular recognition site; other site 291331002406 dimerization interface [polypeptide binding]; other site 291331002407 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331002408 DNA binding site [nucleotide binding] 291331002409 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 291331002410 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331002411 Transposase domain (DUF772); Region: DUF772; cl12084 291331002412 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331002413 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 291331002414 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 291331002415 active site 291331002416 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 291331002417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331002418 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331002419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331002420 Ion transport protein; Region: Ion_trans; pfam00520 291331002421 Ion channel; Region: Ion_trans_2; cl11596 291331002422 acetylornithine transaminase protein; Provisional; Region: argD; PRK04612 291331002423 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 291331002424 inhibitor-cofactor binding pocket; inhibition site 291331002425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331002426 catalytic residue [active] 291331002427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 291331002429 Cytochrome c; Region: Cytochrom_C; cl11414 291331002430 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 291331002431 homotrimer interaction site [polypeptide binding]; other site 291331002432 putative active site [active] 291331002433 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 291331002435 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 291331002436 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 291331002437 inhibitor-cofactor binding pocket; inhibition site 291331002438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331002439 catalytic residue [active] 291331002440 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 291331002441 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331002442 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331002443 Integrase core domain; Region: rve; cl01316 291331002444 Integrase core domain; Region: rve; cl01316 291331002445 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331002446 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331002447 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331002448 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331002449 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331002450 Integrase core domain; Region: rve; cl01316 291331002451 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331002452 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 291331002453 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 291331002454 substrate binding site [chemical binding]; other site 291331002455 active site 291331002456 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 291331002457 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 291331002458 active site 291331002459 dimer interface [polypeptide binding]; other site 291331002460 metal binding site [ion binding]; metal-binding site 291331002461 shikimate kinase; Reviewed; Region: aroK; PRK00131 291331002462 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 291331002463 ADP binding site [chemical binding]; other site 291331002464 magnesium binding site [ion binding]; other site 291331002465 putative shikimate binding site; other site 291331002466 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 291331002467 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 291331002468 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 291331002469 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 291331002470 PspA/IM30 family; Region: PspA_IM30; pfam04012 291331002471 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 291331002472 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 291331002473 Predicted membrane protein [Function unknown]; Region: COG3766 291331002474 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 291331002475 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 291331002476 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 291331002477 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 291331002478 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 291331002479 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 291331002480 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 291331002481 DNA binding residues [nucleotide binding] 291331002482 dimer interface [polypeptide binding]; other site 291331002483 [2Fe-2S] cluster binding site [ion binding]; other site 291331002484 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 291331002485 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331002486 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331002487 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331002488 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331002489 SapC; Region: SapC; pfam07277 291331002490 Uncharacterized conserved protein [Function unknown]; Region: COG2850 291331002491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331002492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 291331002493 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 291331002494 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 291331002495 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 291331002496 Autoinducer binding domain; Region: Autoind_bind; pfam03472 291331002497 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 291331002498 DNA binding residues [nucleotide binding] 291331002499 dimerization interface [polypeptide binding]; other site 291331002500 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 291331002501 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 291331002502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331002503 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331002504 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 291331002505 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 291331002506 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 291331002507 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331002508 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 291331002509 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331002510 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 291331002511 MgtE intracellular N domain; Region: MgtE_N; cl15244 291331002512 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 291331002513 Divalent cation transporter; Region: MgtE; cl00786 291331002514 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 291331002515 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 291331002516 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 291331002517 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 291331002518 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 291331002519 dimerization domain swap beta strand [polypeptide binding]; other site 291331002520 regulatory protein interface [polypeptide binding]; other site 291331002521 active site 291331002522 regulatory phosphorylation site [posttranslational modification]; other site 291331002523 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 291331002524 active pocket/dimerization site; other site 291331002525 active site 291331002526 phosphorylation site [posttranslational modification] 291331002527 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 291331002528 HPr kinase/phosphorylase; Provisional; Region: PRK05428 291331002529 DRTGG domain; Region: DRTGG; cl12147 291331002530 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 291331002531 Hpr binding site; other site 291331002532 active site 291331002533 homohexamer subunit interaction site [polypeptide binding]; other site 291331002534 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 291331002535 active site 291331002536 phosphorylation site [posttranslational modification] 291331002537 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 291331002538 30S subunit binding site; other site 291331002539 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 291331002540 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 291331002541 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 291331002542 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 291331002543 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 291331002544 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 291331002545 Walker A/P-loop; other site 291331002546 ATP binding site [chemical binding]; other site 291331002547 Q-loop/lid; other site 291331002548 ABC transporter signature motif; other site 291331002549 Walker B; other site 291331002550 D-loop; other site 291331002551 H-loop/switch region; other site 291331002552 OstA-like protein; Region: OstA; cl00844 291331002553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 291331002554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 291331002555 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 291331002556 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 291331002557 putative active site [active] 291331002558 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 291331002559 BolA-like protein; Region: BolA; cl00386 291331002560 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 291331002561 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 291331002562 hinge; other site 291331002563 active site 291331002564 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 291331002565 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 291331002566 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 291331002567 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 291331002568 active site 291331002569 substrate binding site [chemical binding]; other site 291331002570 cosubstrate binding site; other site 291331002571 catalytic site [active] 291331002572 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 291331002573 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 291331002574 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 291331002575 dimerization interface [polypeptide binding]; other site 291331002576 putative ATP binding site [chemical binding]; other site 291331002577 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; cl01278 291331002578 Domain of unknown function DUF20; Region: UPF0118; cl00465 291331002579 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331002580 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 291331002581 Substrate binding site [chemical binding]; other site 291331002582 metal binding site [ion binding]; metal-binding site 291331002583 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 291331002584 Phosphotransferase enzyme family; Region: APH; pfam01636 291331002585 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 291331002586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331002587 Integrase core domain; Region: rve; cl01316 291331002588 M28, and M42; Region: Zinc_peptidase_like; cl14876 291331002589 metal binding site [ion binding]; metal-binding site 291331002590 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 291331002593 Transposase domain (DUF772); Region: DUF772; cl12084 291331002594 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331002595 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331002596 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 291331002597 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 291331002598 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 291331002599 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 291331002600 active site 291331002601 catalytic residues [active] 291331002602 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 291331002603 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331002604 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331002605 signal recognition particle protein; Provisional; Region: PRK10867 291331002606 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 291331002607 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 291331002608 P loop; other site 291331002609 GTP binding site [chemical binding]; other site 291331002610 Signal peptide binding domain; Region: SRP_SPB; pfam02978 291331002611 Nitronate monooxygenase; Region: NMO; pfam03060 291331002612 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 291331002613 FMN binding site [chemical binding]; other site 291331002614 substrate binding site [chemical binding]; other site 291331002615 putative catalytic residue [active] 291331002616 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 291331002617 homodimer interface [polypeptide binding]; other site 291331002618 substrate-cofactor binding pocket; other site 291331002619 Aminotransferase class IV; Region: Aminotran_4; pfam01063 291331002620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331002621 catalytic residue [active] 291331002622 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 291331002623 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 291331002624 RimM N-terminal domain; Region: RimM; pfam01782 291331002625 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 291331002626 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 291331002627 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 291331002628 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 291331002629 MatE; Region: MatE; pfam01554 291331002630 MatE; Region: MatE; pfam01554 291331002631 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 291331002632 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331002633 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331002634 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331002635 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331002636 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 291331002637 GSH binding site (G-site) [chemical binding]; other site 291331002638 C-terminal domain interface [polypeptide binding]; other site 291331002639 dimer interface [polypeptide binding]; other site 291331002640 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 291331002641 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 291331002642 Clp amino terminal domain; Region: Clp_N; pfam02861 291331002643 Clp amino terminal domain; Region: Clp_N; pfam02861 291331002644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331002645 Walker A motif; other site 291331002646 ATP binding site [chemical binding]; other site 291331002647 Walker B motif; other site 291331002648 arginine finger; other site 291331002649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331002650 Walker A motif; other site 291331002651 ATP binding site [chemical binding]; other site 291331002652 Walker B motif; other site 291331002653 arginine finger; other site 291331002654 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 291331002655 Integrase core domain; Region: rve; cl01316 291331002656 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331002657 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 291331002658 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331002659 N-terminal plug; other site 291331002660 ligand-binding site [chemical binding]; other site 291331002661 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331002662 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 291331002663 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 291331002664 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 291331002665 homodimer interface [polypeptide binding]; other site 291331002666 Walker A motif; other site 291331002667 ATP binding site [chemical binding]; other site 291331002668 hydroxycobalamin binding site [chemical binding]; other site 291331002669 Walker B motif; other site 291331002670 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 291331002671 homotrimer interface [polypeptide binding]; other site 291331002672 Walker A motif; other site 291331002673 GTP binding site [chemical binding]; other site 291331002674 Walker B motif; other site 291331002675 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 291331002676 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 291331002677 putative dimer interface [polypeptide binding]; other site 291331002678 active site pocket [active] 291331002679 putative cataytic base [active] 291331002680 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 291331002681 catalytic core [active] 291331002682 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 291331002683 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 291331002684 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 291331002685 dimer interface [polypeptide binding]; other site 291331002686 active site 291331002687 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 291331002688 catalytic residues [active] 291331002689 substrate binding site [chemical binding]; other site 291331002690 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 291331002691 IucA / IucC family; Region: IucA_IucC; pfam04183 291331002692 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 291331002693 drug efflux system protein MdtG; Provisional; Region: PRK09874 291331002694 IucA / IucC family; Region: IucA_IucC; pfam04183 291331002695 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 291331002696 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331002697 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 291331002698 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331002699 N-terminal plug; other site 291331002700 ligand-binding site [chemical binding]; other site 291331002701 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 291331002702 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 291331002703 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331002704 putative transposase OrfB; Reviewed; Region: PHA02517 291331002705 Integrase core domain; Region: rve; cl01316 291331002706 putative cation:proton antiport protein; Provisional; Region: PRK10669 291331002707 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 291331002708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331002709 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 291331002710 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331002711 N-terminal plug; other site 291331002712 ligand-binding site [chemical binding]; other site 291331002713 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 291331002714 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331002715 N-terminal plug; other site 291331002716 ligand-binding site [chemical binding]; other site 291331002717 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 291331002718 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 291331002719 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331002720 N-terminal plug; other site 291331002721 ligand-binding site [chemical binding]; other site 291331002722 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 291331002723 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 291331002724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331002725 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 291331002726 ABC transporter; Region: ABC_tran_2; pfam12848 291331002727 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 291331002728 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 291331002729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331002730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331002731 dimerization interface [polypeptide binding]; other site 291331002732 Beta-lactamase; Region: Beta-lactamase; cl01009 291331002733 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331002734 Protein of unknown function (DUF805); Region: DUF805; cl01224 291331002735 Protein of unknown function (DUF805); Region: DUF805; cl01224 291331002736 Transposase domain (DUF772); Region: DUF772; cl12084 291331002737 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331002738 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 291331002739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 291331002740 active site 291331002741 phosphorylation site [posttranslational modification] 291331002742 intermolecular recognition site; other site 291331002743 dimerization interface [polypeptide binding]; other site 291331002744 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331002745 DNA binding site [nucleotide binding] 291331002746 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 291331002747 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 291331002748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 291331002749 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 291331002750 Integrase core domain; Region: rve; cl01316 291331002751 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331002752 Transposase domain (DUF772); Region: DUF772; cl12084 291331002753 Transposase, Mutator family; Region: Transposase_mut; pfam00872 291331002754 MULE transposase domain; Region: MULE; pfam10551 291331002755 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 291331002756 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 291331002757 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 291331002758 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 291331002759 proposed active site lysine [active] 291331002760 conserved cys residue [active] 291331002761 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 291331002762 Fatty acid desaturase; Region: FA_desaturase; pfam00487 291331002763 putative di-iron ligands [ion binding]; other site 291331002764 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 291331002765 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 291331002766 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291331002767 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331002768 catalytic residue [active] 291331002769 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291331002770 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331002771 catalytic residue [active] 291331002772 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331002773 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331002775 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331002776 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 291331002777 [2Fe-2S] cluster binding site [ion binding]; other site 291331002778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 291331002779 Coenzyme A binding pocket [chemical binding]; other site 291331002780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331002781 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 291331002782 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 291331002783 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331002784 catalytic residue [active] 291331002785 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 291331002786 FeS assembly ATPase SufC; Region: sufC; TIGR01978 291331002787 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 291331002788 Walker A/P-loop; other site 291331002789 ATP binding site [chemical binding]; other site 291331002790 Q-loop/lid; other site 291331002791 ABC transporter signature motif; other site 291331002792 Walker B; other site 291331002793 D-loop; other site 291331002794 H-loop/switch region; other site 291331002795 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 291331002796 putative ABC transporter; Region: ycf24; CHL00085 291331002797 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 291331002798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331002799 SET domain; Region: SET; cl02566 291331002800 Peptidase family M23; Region: Peptidase_M23; pfam01551 291331002801 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cl00257 291331002802 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331002803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331002804 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 291331002805 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 291331002806 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 291331002807 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 291331002808 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 291331002809 Walker A motif; other site 291331002810 ATP binding site [chemical binding]; other site 291331002811 Walker B motif; other site 291331002812 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 291331002813 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 291331002814 Walker A motif; other site 291331002815 ATP binding site [chemical binding]; other site 291331002816 Walker B motif; other site 291331002818 Protein of unknown function DUF72; Region: DUF72; cl00777 291331002819 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 291331002820 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 291331002821 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 291331002822 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 291331002823 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 291331002824 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 291331002825 OsmC-like protein; Region: OsmC; cl00767 291331002826 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 291331002827 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 291331002828 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 291331002829 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 291331002830 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 291331002831 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 291331002832 nucleotide binding site [chemical binding]; other site 291331002833 substrate binding site [chemical binding]; other site 291331002834 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935 291331002835 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 291331002836 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 291331002837 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 291331002838 catalytic residue [active] 291331002839 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 291331002840 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 291331002841 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 291331002842 octaprenyl diphosphate synthase; Provisional; Region: PRK10888 291331002843 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 291331002844 substrate binding pocket [chemical binding]; other site 291331002845 chain length determination region; other site 291331002846 substrate-Mg2+ binding site; other site 291331002847 catalytic residues [active] 291331002848 aspartate-rich region 1; other site 291331002849 active site lid residues [active] 291331002850 aspartate-rich region 2; other site 291331002851 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 291331002852 dimer interface [polypeptide binding]; other site 291331002853 ssDNA binding site [nucleotide binding]; other site 291331002854 tetramer (dimer of dimers) interface [polypeptide binding]; other site 291331002855 Cache domain; Region: Cache_1; pfam02743 291331002856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331002857 metal binding site [ion binding]; metal-binding site 291331002858 active site 291331002859 I-site; other site 291331002860 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331002861 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331002862 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331002863 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 291331002864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 291331002865 motif II; other site 291331002866 Protein of unknown function (DUF466); Region: DUF466; cl01082 291331002867 Carbon starvation protein CstA; Region: CstA; cl00856 291331002868 Pirin-related protein [General function prediction only]; Region: COG1741 291331002869 Cupin domain; Region: Cupin_2; cl09118 291331002870 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 291331002871 OsmC-like protein; Region: OsmC; cl00767 291331002872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 291331002873 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331002874 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331002875 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 291331002876 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331002877 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331002878 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 291331002879 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 291331002880 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 291331002881 Pirin-related protein [General function prediction only]; Region: COG1741 291331002882 Cupin domain; Region: Cupin_2; cl09118 291331002883 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 291331002884 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 291331002885 Active_site [active] 291331002886 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 291331002887 catalytic core [active] 291331002888 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 291331002889 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 291331002890 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 291331002891 active site 291331002892 Zn binding site [ion binding]; other site 291331002894 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 291331002895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331002896 active site 291331002897 phosphorylation site [posttranslational modification] 291331002898 intermolecular recognition site; other site 291331002899 dimerization interface [polypeptide binding]; other site 291331002900 CheB methylesterase; Region: CheB_methylest; pfam01339 291331002901 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 291331002902 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 291331002903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331002904 Response regulator receiver domain; Region: Response_reg; pfam00072 291331002905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331002906 active site 291331002907 phosphorylation site [posttranslational modification] 291331002908 intermolecular recognition site; other site 291331002909 dimerization interface [polypeptide binding]; other site 291331002910 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 291331002911 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 291331002912 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 291331002913 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 291331002914 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 291331002915 putative binding surface; other site 291331002916 active site 291331002917 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 291331002918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331002919 ATP binding site [chemical binding]; other site 291331002920 Mg2+ binding site [ion binding]; other site 291331002921 G-X-G motif; other site 291331002922 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 291331002923 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 291331002924 anti sigma factor interaction site; other site 291331002925 regulatory phosphorylation site [posttranslational modification]; other site 291331002926 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 291331002927 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 291331002928 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 291331002929 ATP binding site [chemical binding]; other site 291331002930 putative Mg++ binding site [ion binding]; other site 291331002931 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331002932 nucleotide binding region [chemical binding]; other site 291331002933 ATP-binding site [chemical binding]; other site 291331002934 TRCF domain; Region: TRCF; pfam03461 291331002935 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 291331002936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331002937 Protein of unknown function (DUF519); Region: DUF519; cl04492 291331002938 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331002939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331002940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331002941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331002942 ATP binding site [chemical binding]; other site 291331002943 Mg2+ binding site [ion binding]; other site 291331002944 G-X-G motif; other site 291331002945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331002946 Integrase core domain; Region: rve; cl01316 291331002947 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 291331002948 active site 291331002949 Inner membrane protein CreD; Region: CreD; cl01844 291331002951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331002952 Integrase core domain; Region: rve; cl01316 291331002953 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 291331002954 active site 291331002955 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 291331002956 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331002957 Integrase core domain; Region: rve; cl01316 291331002958 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 291331002959 putative active site [active] 291331002960 catalytic triad [active] 291331002961 putative dimer interface [polypeptide binding]; other site 291331002962 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 291331002963 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 291331002964 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 291331002965 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 291331002966 active site 291331002967 HIGH motif; other site 291331002968 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 291331002969 active site 291331002970 KMSKS motif; other site 291331002971 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 291331002972 metal binding site 2 [ion binding]; metal-binding site 291331002973 putative DNA binding helix; other site 291331002974 metal binding site 1 [ion binding]; metal-binding site 291331002975 dimer interface [polypeptide binding]; other site 291331002976 structural Zn2+ binding site [ion binding]; other site 291331002978 Transposase domain (DUF772); Region: DUF772; cl12084 291331002979 Protein of unknown function (DUF456); Region: DUF456; cl01069 291331002980 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 291331002981 DNA-binding site [nucleotide binding]; DNA binding site 291331002982 RNA-binding motif; other site 291331002983 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 291331002984 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 291331002985 putative ATP binding site [chemical binding]; other site 291331002986 putative substrate interface [chemical binding]; other site 291331002987 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 291331002988 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 291331002989 active site 291331002990 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 291331002991 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 291331002992 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 291331002993 active site 291331002994 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 291331002995 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 291331002996 putative C-terminal domain interface [polypeptide binding]; other site 291331002997 putative GSH binding site (G-site) [chemical binding]; other site 291331002998 putative dimer interface [polypeptide binding]; other site 291331002999 GST_C family, unknown subfamily 1; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_1; cd03179 291331003000 putative N-terminal domain interface [polypeptide binding]; other site 291331003001 putative dimer interface [polypeptide binding]; other site 291331003002 putative substrate binding pocket (H-site) [chemical binding]; other site 291331003003 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 291331003004 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 291331003005 active site 291331003006 dimer interface [polypeptide binding]; other site 291331003007 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 291331003008 Ligand Binding Site [chemical binding]; other site 291331003009 Molecular Tunnel; other site 291331003010 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 291331003011 replicative DNA helicase; Provisional; Region: PRK08760 291331003012 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 291331003013 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 291331003014 Walker A motif; other site 291331003015 ATP binding site [chemical binding]; other site 291331003016 Walker B motif; other site 291331003017 DNA binding loops [nucleotide binding] 291331003018 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 291331003019 DNA photolyase; Region: DNA_photolyase; pfam00875 291331003020 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 291331003021 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 291331003022 ligand binding site [chemical binding]; other site 291331003023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331003024 active site 291331003025 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331003026 Integrase core domain; Region: rve; cl01316 291331003027 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 291331003028 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331003029 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331003030 MerC mercury resistance protein; Region: MerC; cl03934 291331003031 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 291331003032 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 291331003033 putative NAD(P) binding site [chemical binding]; other site 291331003034 catalytic Zn binding site [ion binding]; other site 291331003035 structural Zn binding site [ion binding]; other site 291331003036 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 291331003037 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 291331003038 putative ion selectivity filter; other site 291331003039 putative pore gating glutamate residue; other site 291331003040 putative H+/Cl- coupling transport residue; other site 291331003042 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 291331003043 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 291331003044 DNA binding site [nucleotide binding] 291331003045 active site 291331003046 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 291331003047 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 291331003048 AlkA N-terminal domain; Region: AlkA_N; pfam06029 291331003049 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 291331003050 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 291331003051 minor groove reading motif; other site 291331003052 helix-hairpin-helix signature motif; other site 291331003053 substrate binding pocket [chemical binding]; other site 291331003054 active site 291331003055 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 291331003056 MAPEG family; Region: MAPEG; cl09190 291331003057 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 291331003058 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 291331003059 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 291331003060 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 291331003061 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 291331003062 ATP binding site [chemical binding]; other site 291331003063 Mg++ binding site [ion binding]; other site 291331003064 motif III; other site 291331003065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331003066 nucleotide binding region [chemical binding]; other site 291331003067 ATP-binding site [chemical binding]; other site 291331003068 DbpA RNA binding domain; Region: DbpA; pfam03880 291331003069 PAS domain S-box; Region: sensory_box; TIGR00229 291331003070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 291331003071 putative active site [active] 291331003072 heme pocket [chemical binding]; other site 291331003073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331003074 metal binding site [ion binding]; metal-binding site 291331003075 active site 291331003076 I-site; other site 291331003077 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 291331003078 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 291331003079 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 291331003080 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 291331003081 probable active site [active] 291331003083 Protein of unknown function DUF72; Region: DUF72; cl00777 291331003084 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 291331003085 Beta-lactamase; Region: Beta-lactamase; cl01009 291331003086 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 291331003087 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 291331003088 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 291331003089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 291331003090 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 291331003091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331003092 dimer interface [polypeptide binding]; other site 291331003093 phosphorylation site [posttranslational modification] 291331003094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331003095 ATP binding site [chemical binding]; other site 291331003096 Mg2+ binding site [ion binding]; other site 291331003097 G-X-G motif; other site 291331003098 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 291331003099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331003100 active site 291331003101 phosphorylation site [posttranslational modification] 291331003102 intermolecular recognition site; other site 291331003103 dimerization interface [polypeptide binding]; other site 291331003104 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331003105 DNA binding site [nucleotide binding] 291331003106 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 291331003107 Outer membrane efflux protein; Region: OEP; pfam02321 291331003108 Outer membrane efflux protein; Region: OEP; pfam02321 291331003109 MltA-interacting protein MipA; Region: MipA; cl01504 291331003110 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 291331003111 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 291331003112 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 291331003113 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 291331003114 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 291331003115 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 291331003116 Walker A/P-loop; other site 291331003117 ATP binding site [chemical binding]; other site 291331003118 Q-loop/lid; other site 291331003119 ABC transporter signature motif; other site 291331003120 Walker B; other site 291331003121 D-loop; other site 291331003122 H-loop/switch region; other site 291331003123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331003124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331003125 Integrase core domain; Region: rve; cl01316 291331003126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331003128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331003129 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331003130 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331003131 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331003132 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331003134 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 291331003135 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 291331003136 RHS Repeat; Region: RHS_repeat; cl11982 291331003137 RHS Repeat; Region: RHS_repeat; cl11982 291331003138 RHS Repeat; Region: RHS_repeat; cl11982 291331003139 RHS Repeat; Region: RHS_repeat; cl11982 291331003140 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 291331003141 Transposase domain (DUF772); Region: DUF772; cl12084 291331003142 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331003143 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 291331003144 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 291331003145 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331003146 Integrase core domain; Region: rve; cl01316 291331003147 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331003148 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 291331003149 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 291331003150 CoA-binding site [chemical binding]; other site 291331003151 ATP-binding [chemical binding]; other site 291331003152 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 291331003153 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 291331003154 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 291331003155 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 291331003156 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 291331003157 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 291331003158 Pilin (bacterial filament); Region: Pilin; pfam00114 291331003159 Sulfatase; Region: Sulfatase; cl10460 291331003160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331003161 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 291331003162 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 291331003163 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 291331003164 Walker A motif; other site 291331003165 ATP binding site [chemical binding]; other site 291331003166 Walker B motif; other site 291331003167 Fic/DOC family; Region: Fic; cl00960 291331003168 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 291331003169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331003170 active site 291331003171 phosphorylation site [posttranslational modification] 291331003172 intermolecular recognition site; other site 291331003173 dimerization interface [polypeptide binding]; other site 291331003174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331003175 Walker A motif; other site 291331003176 ATP binding site [chemical binding]; other site 291331003177 Walker B motif; other site 291331003178 arginine finger; other site 291331003179 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 291331003180 Predicted integral membrane protein [Function unknown]; Region: COG5617 291331003181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 291331003182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331003183 dimer interface [polypeptide binding]; other site 291331003184 phosphorylation site [posttranslational modification] 291331003185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331003186 ATP binding site [chemical binding]; other site 291331003187 Mg2+ binding site [ion binding]; other site 291331003188 G-X-G motif; other site 291331003189 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 291331003190 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331003191 CoA-ligase; Region: Ligase_CoA; pfam00549 291331003192 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 291331003193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331003194 CoA-ligase; Region: Ligase_CoA; pfam00549 291331003195 NAD synthetase; Provisional; Region: PRK13981 291331003196 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 291331003197 multimer interface [polypeptide binding]; other site 291331003198 active site 291331003199 catalytic triad [active] 291331003200 protein interface 1 [polypeptide binding]; other site 291331003201 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 291331003202 homodimer interface [polypeptide binding]; other site 291331003203 NAD binding pocket [chemical binding]; other site 291331003204 ATP binding pocket [chemical binding]; other site 291331003205 Mg binding site [ion binding]; other site 291331003206 active-site loop [active] 291331003207 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 291331003208 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 291331003209 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 291331003210 RNA binding surface [nucleotide binding]; other site 291331003211 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 291331003212 active site 291331003213 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 291331003214 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 291331003215 Protein of unknown function, DUF393; Region: DUF393; cl01136 291331003216 Protein of unknown function, DUF393; Region: DUF393; cl01136 291331003217 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 291331003218 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 291331003219 active site 291331003220 homotetramer interface [polypeptide binding]; other site 291331003221 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 291331003222 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 291331003223 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 291331003224 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 291331003225 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 291331003226 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331003227 N-terminal plug; other site 291331003228 ligand-binding site [chemical binding]; other site 291331003229 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 291331003230 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 291331003231 active site 291331003232 catalytic residues [active] 291331003233 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 291331003234 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 291331003235 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 291331003236 Secreted protein acidic and rich in cysteine Ca binding region; Region: SPARC_Ca_bdg; pfam10591 291331003237 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 291331003238 Ca2+ binding site [ion binding]; other site 291331003239 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 291331003240 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 291331003241 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 291331003242 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 291331003243 active site 291331003244 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 291331003245 catalytic triad [active] 291331003246 dimer interface [polypeptide binding]; other site 291331003247 enoyl-CoA hydratase; Provisional; Region: PRK07854 291331003248 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 291331003249 substrate binding site [chemical binding]; other site 291331003250 oxyanion hole (OAH) forming residues; other site 291331003251 trimer interface [polypeptide binding]; other site 291331003252 Protein of unknown function (DUF461); Region: DUF461; cl01071 291331003253 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 291331003254 active site 291331003256 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 291331003257 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 291331003258 GTPase CgtA; Reviewed; Region: obgE; PRK12299 291331003259 GTP1/OBG; Region: GTP1_OBG; pfam01018 291331003260 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 291331003261 G1 box; other site 291331003262 GTP/Mg2+ binding site [chemical binding]; other site 291331003263 Switch I region; other site 291331003264 G2 box; other site 291331003265 G3 box; other site 291331003266 Switch II region; other site 291331003267 G4 box; other site 291331003268 G5 box; other site 291331003269 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 291331003270 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 291331003271 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 291331003272 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 291331003273 active site 291331003274 Riboflavin kinase; Region: Flavokinase; pfam01687 291331003275 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 291331003276 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291331003277 active site 291331003278 HIGH motif; other site 291331003279 nucleotide binding site [chemical binding]; other site 291331003280 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 291331003281 active site 291331003282 KMSKS motif; other site 291331003283 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 291331003284 tRNA binding surface [nucleotide binding]; other site 291331003285 anticodon binding site; other site 291331003286 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 291331003287 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 291331003288 LytB protein; Region: LYTB; cl00507 291331003289 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 291331003290 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 291331003291 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 291331003292 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 291331003293 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 291331003294 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 291331003295 D-pathway; other site 291331003296 Putative ubiquinol binding site [chemical binding]; other site 291331003297 Low-spin heme (heme b) binding site [chemical binding]; other site 291331003298 Putative water exit pathway; other site 291331003299 Binuclear center (heme o3/CuB) [ion binding]; other site 291331003300 K-pathway; other site 291331003301 Putative proton exit pathway; other site 291331003302 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 291331003303 Subunit I/III interface [polypeptide binding]; other site 291331003304 Subunit III/IV interface [polypeptide binding]; other site 291331003305 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 291331003306 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 291331003307 Tetratricopeptide repeat; Region: TPR_3; pfam07720 291331003308 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 291331003309 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 291331003310 protein binding site [polypeptide binding]; other site 291331003311 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 291331003312 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331003313 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 291331003314 RHS Repeat; Region: RHS_repeat; cl11982 291331003315 RHS Repeat; Region: RHS_repeat; cl11982 291331003316 RHS Repeat; Region: RHS_repeat; cl11982 291331003317 RHS Repeat; Region: RHS_repeat; cl11982 291331003318 RHS Repeat; Region: RHS_repeat; cl11982 291331003319 RHS Repeat; Region: RHS_repeat; cl11982 291331003320 RHS Repeat; Region: RHS_repeat; cl11982 291331003321 RHS Repeat; Region: RHS_repeat; cl11982 291331003322 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 291331003323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331003324 Integrase core domain; Region: rve; cl01316 291331003325 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 291331003326 RHS Repeat; Region: RHS_repeat; cl11982 291331003327 RHS Repeat; Region: RHS_repeat; cl11982 291331003328 RHS Repeat; Region: RHS_repeat; cl11982 291331003329 RHS Repeat; Region: RHS_repeat; cl11982 291331003330 RHS Repeat; Region: RHS_repeat; cl11982 291331003331 RHS Repeat; Region: RHS_repeat; cl11982 291331003332 RHS Repeat; Region: RHS_repeat; cl11982 291331003333 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 291331003334 RHS Repeat; Region: RHS_repeat; cl11982 291331003335 RHS Repeat; Region: RHS_repeat; cl11982 291331003336 RHS Repeat; Region: RHS_repeat; cl11982 291331003337 RHS Repeat; Region: RHS_repeat; cl11982 291331003338 RHS Repeat; Region: RHS_repeat; cl11982 291331003339 RHS Repeat; Region: RHS_repeat; cl11982 291331003340 putative transposase OrfB; Reviewed; Region: PHA02517 291331003341 Integrase core domain; Region: rve; cl01316 291331003342 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 291331003343 MutS domain I; Region: MutS_I; pfam01624 291331003344 MutS domain II; Region: MutS_II; pfam05188 291331003345 MutS family domain IV; Region: MutS_IV; pfam05190 291331003346 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 291331003347 Walker A/P-loop; other site 291331003348 ATP binding site [chemical binding]; other site 291331003349 Q-loop/lid; other site 291331003350 ABC transporter signature motif; other site 291331003351 Walker B; other site 291331003352 D-loop; other site 291331003353 H-loop/switch region; other site 291331003354 putative transposase OrfB; Reviewed; Region: PHA02517 291331003355 Integrase core domain; Region: rve; cl01316 291331003356 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331003357 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331003358 DNA repair protein RadA; Provisional; Region: PRK11823 291331003359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331003360 Walker A motif; other site 291331003361 ATP binding site [chemical binding]; other site 291331003362 Walker B motif; other site 291331003363 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 291331003364 Integrase core domain; Region: rve; cl01316 291331003365 putative transposase OrfB; Reviewed; Region: PHA02517 291331003366 Integrase core domain; Region: rve; cl01316 291331003367 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331003368 Phosphoesterase family; Region: Phosphoesterase; cl10627 291331003369 Domain of unknown function (DUF756); Region: DUF756; pfam05506 291331003370 Domain of unknown function (DUF756); Region: DUF756; pfam05506 291331003371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331003372 putative substrate translocation pore; other site 291331003373 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 291331003374 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 291331003375 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 291331003376 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 291331003377 dimer interface [polypeptide binding]; other site 291331003378 anticodon binding site; other site 291331003379 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 291331003380 homodimer interface [polypeptide binding]; other site 291331003381 motif 1; other site 291331003382 active site 291331003383 motif 2; other site 291331003384 GAD domain; Region: GAD; pfam02938 291331003385 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 291331003386 motif 3; other site 291331003387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331003388 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 291331003389 Domain of unknown function DUF28; Region: DUF28; cl00361 291331003390 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 291331003391 active site 291331003392 putative DNA-binding cleft [nucleotide binding]; other site 291331003393 dimer interface [polypeptide binding]; other site 291331003394 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 291331003395 RuvA N terminal domain; Region: RuvA_N; pfam01330 291331003396 K+ potassium transporter; Region: K_trans; cl01227 291331003397 potassium uptake protein; Region: kup; TIGR00794 291331003398 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 291331003399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331003400 Walker A motif; other site 291331003401 ATP binding site [chemical binding]; other site 291331003402 Walker B motif; other site 291331003403 arginine finger; other site 291331003404 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 291331003405 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 291331003406 active site 291331003407 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 291331003408 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 291331003409 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 291331003410 TolA protein; Region: tolA_full; TIGR02794 291331003411 translocation protein TolB; Provisional; Region: tolB; PRK04922 291331003412 TolB amino-terminal domain; Region: TolB_N; pfam04052 291331003413 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 291331003414 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 291331003415 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 291331003416 ligand binding site [chemical binding]; other site 291331003417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 291331003418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 291331003419 binding surface 291331003420 TPR motif; other site 291331003421 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 291331003422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 291331003423 FeS/SAM binding site; other site 291331003424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331003425 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331003426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331003427 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331003428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331003429 Transposase domain (DUF772); Region: DUF772; cl12084 291331003430 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 291331003431 Ligand Binding Site [chemical binding]; other site 291331003432 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 291331003433 DNA binding site [nucleotide binding] 291331003434 Int/Topo IB signature motif; other site 291331003435 active site 291331003436 catalytic residues [active] 291331003437 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication...; Region: TOPRIM_primases; cd01029 291331003438 active site 291331003439 metal binding site [ion binding]; metal-binding site 291331003440 interdomain interaction site; other site 291331003441 Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl04623 291331003442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 291331003443 Phage protein D [General function prediction only]; Region: COG3500; cl12180 291331003444 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 291331003445 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 291331003446 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 291331003447 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 291331003448 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 291331003449 Phage tail protein E; Region: Phage_E; pfam06158 291331003450 Phage tail tube protein FII; Region: Phage_tube; cl01390 291331003451 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 291331003452 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 291331003453 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331003454 Phage Tail Collar Domain; Region: Collar; pfam07484 291331003455 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 291331003456 Baseplate J-like protein; Region: Baseplate_J; cl01294 291331003457 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 291331003458 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 291331003459 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 291331003460 Protein of unknown function (DUF754); Region: DUF754; pfam05449 291331003461 Phage Tail Protein X; Region: Phage_tail_X; cl02088 291331003462 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 291331003463 Phage small terminase subunit; Region: Phage_term_smal; cl05485 291331003464 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 291331003465 capsid-scaffolding protein; Provisional; Region: O; PHA02529 291331003466 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 291331003467 terminase ATPase subunit; Provisional; Region: P; PHA02535 291331003468 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 291331003469 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 291331003470 Phage-related protein [Function unknown]; Region: COG4695; cl01923 291331003471 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 291331003472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331003473 Response regulator receiver domain; Region: Response_reg; pfam00072 291331003474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331003475 active site 291331003476 phosphorylation site [posttranslational modification] 291331003477 intermolecular recognition site; other site 291331003478 dimerization interface [polypeptide binding]; other site 291331003479 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 291331003480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 291331003481 ATP binding site [chemical binding]; other site 291331003482 putative Mg++ binding site [ion binding]; other site 291331003483 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331003484 nucleotide binding region [chemical binding]; other site 291331003485 ATP-binding site [chemical binding]; other site 291331003486 RQC domain; Region: RQC; pfam09382 291331003487 HRDC domain; Region: HRDC; cl02578 291331003488 Ferritin-like domain; Region: Ferritin; pfam00210 291331003489 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 291331003490 dimerization interface [polypeptide binding]; other site 291331003491 DPS ferroxidase diiron center [ion binding]; other site 291331003492 ion pore; other site 291331003493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 291331003494 ATP binding site [chemical binding]; other site 291331003495 putative Mg++ binding site [ion binding]; other site 291331003496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331003497 nucleotide binding region [chemical binding]; other site 291331003498 ATP-binding site [chemical binding]; other site 291331003499 Helicase associated domain (HA2); Region: HA2; cl04503 291331003500 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 291331003501 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 291331003502 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331003503 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331003504 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331003505 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331003506 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331003507 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 291331003508 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 291331003509 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 291331003510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 291331003511 FeS/SAM binding site; other site 291331003512 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 291331003513 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 291331003514 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 291331003515 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 291331003516 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 291331003517 synthetase active site [active] 291331003518 NTP binding site [chemical binding]; other site 291331003519 metal binding site [ion binding]; metal-binding site 291331003520 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 291331003521 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 291331003522 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 291331003523 Probable Catalytic site [active] 291331003524 metal binding site [ion binding]; metal-binding site 291331003525 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 291331003526 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 291331003527 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 291331003528 Transglycosylase; Region: Transgly; cl07896 291331003529 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 291331003530 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 291331003531 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 291331003532 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 291331003533 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 291331003534 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 291331003535 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 291331003536 Gram-negative bacterial tonB protein; Region: TonB; cl10048 291331003537 glutathione synthetase; Provisional; Region: PRK05246 291331003538 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 291331003539 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331003540 Response regulator receiver domain; Region: Response_reg; pfam00072 291331003541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331003542 active site 291331003543 phosphorylation site [posttranslational modification] 291331003544 intermolecular recognition site; other site 291331003545 dimerization interface [polypeptide binding]; other site 291331003546 Response regulator receiver domain; Region: Response_reg; pfam00072 291331003547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331003548 active site 291331003549 phosphorylation site [posttranslational modification] 291331003550 intermolecular recognition site; other site 291331003551 dimerization interface [polypeptide binding]; other site 291331003552 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 291331003553 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 291331003554 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 291331003555 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 291331003556 CheB methylesterase; Region: CheB_methylest; pfam01339 291331003557 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 291331003558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331003559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331003560 Integrase core domain; Region: rve; cl01316 291331003561 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 291331003562 von Willebrand factor; Region: vWF_A; pfam12450 291331003563 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_subgroup; cd01465 291331003564 metal ion-dependent adhesion site (MIDAS); other site 291331003565 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331003566 multicopper oxidase; Provisional; Region: PRK10965 291331003567 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (...; Region: Glycosylasparaginase; cd04513 291331003568 active site 291331003569 dimer interface [polypeptide binding]; other site 291331003570 catalytic nucleophile [active] 291331003571 CutC family; Region: CutC; cl01218 291331003572 Resistant to P. syringae 6; Provisional; Region: PLN03210 291331003573 Resistant to P. syringae 6; Provisional; Region: PLN03210 291331003574 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 291331003575 Asp-box motif; other site 291331003576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331003578 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 291331003579 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 291331003580 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 291331003581 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 291331003582 Uncharacterized conserved protein [Function unknown]; Region: COG3538 291331003583 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 291331003584 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 291331003585 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 291331003586 Transposase domain (DUF772); Region: DUF772; cl12084 291331003587 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331003588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331003589 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331003590 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 291331003591 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 291331003592 putative active site [active] 291331003593 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 291331003594 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331003595 Walker A/P-loop; other site 291331003596 ATP binding site [chemical binding]; other site 291331003597 Q-loop/lid; other site 291331003598 ABC transporter signature motif; other site 291331003599 Walker B; other site 291331003600 D-loop; other site 291331003601 H-loop/switch region; other site 291331003602 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 291331003603 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 291331003604 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 291331003605 PA14 domain; Region: PA14; cl08459 291331003606 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 291331003607 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 291331003608 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 291331003609 domain; Region: Glyco_hydro_2; pfam00703 291331003610 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 291331003611 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i); Region: GH20_chitobiase-like; cd06563 291331003612 active site 291331003613 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 291331003614 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 291331003615 active site 291331003616 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 291331003617 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 291331003618 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 291331003619 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331003620 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331003621 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331003622 ligand-binding site [chemical binding]; other site 291331003623 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 291331003624 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 291331003625 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK08742 291331003626 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 291331003627 inhibitor-cofactor binding pocket; inhibition site 291331003628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331003629 catalytic residue [active] 291331003630 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 291331003631 active site 291331003632 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 291331003633 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 291331003634 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 291331003635 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 291331003636 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 291331003637 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 291331003638 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 291331003639 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 291331003640 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 291331003641 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 291331003642 lipoyl attachment site [posttranslational modification]; other site 291331003643 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 291331003644 Beta-lactamase; Region: Beta-lactamase; cl01009 291331003645 TLC ATP/ADP transporter; Region: TLC; cl03940 291331003646 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 291331003648 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331003649 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 291331003650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 291331003651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 291331003652 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331003653 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331003654 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331003655 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 291331003656 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 291331003657 dimerization interface [polypeptide binding]; other site 291331003658 domain crossover interface; other site 291331003659 redox-dependent activation switch; other site 291331003660 Transglycosylase; Region: Transgly; cl07896 291331003661 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 291331003662 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 291331003663 Ligand binding site [chemical binding]; other site 291331003664 Putative Catalytic site [active] 291331003665 DXD motif; other site 291331003666 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 291331003667 Haemolysin-III related; Region: HlyIII; cl03831 291331003668 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 291331003669 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 291331003670 G1 box; other site 291331003671 putative GEF interaction site [polypeptide binding]; other site 291331003672 GTP/Mg2+ binding site [chemical binding]; other site 291331003673 Switch I region; other site 291331003674 G2 box; other site 291331003675 G3 box; other site 291331003676 Switch II region; other site 291331003677 G4 box; other site 291331003678 G5 box; other site 291331003679 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 291331003680 Peptidase family M23; Region: Peptidase_M23; pfam01551 291331003681 homoserine O-acetyltransferase; Provisional; Region: PRK08775 291331003682 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331003683 cystathionine gamma-synthase; Provisional; Region: PRK08776 291331003684 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 291331003685 homodimer interface [polypeptide binding]; other site 291331003686 substrate-cofactor binding pocket; other site 291331003687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331003688 catalytic residue [active] 291331003689 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 291331003690 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 291331003691 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 291331003692 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 291331003693 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 291331003694 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 291331003695 YceI-like domain; Region: YceI; cl01001 291331003696 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 291331003697 YceI-like domain; Region: YceI; cl01001 291331003698 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 291331003699 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 291331003700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331003701 dimer interface [polypeptide binding]; other site 291331003702 phosphorylation site [posttranslational modification] 291331003703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331003704 ATP binding site [chemical binding]; other site 291331003705 Mg2+ binding site [ion binding]; other site 291331003706 G-X-G motif; other site 291331003707 Response regulator receiver domain; Region: Response_reg; pfam00072 291331003708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331003709 active site 291331003710 phosphorylation site [posttranslational modification] 291331003711 intermolecular recognition site; other site 291331003712 dimerization interface [polypeptide binding]; other site 291331003713 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 291331003714 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 291331003715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331003716 dimer interface [polypeptide binding]; other site 291331003717 phosphorylation site [posttranslational modification] 291331003718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331003719 ATP binding site [chemical binding]; other site 291331003720 Mg2+ binding site [ion binding]; other site 291331003721 G-X-G motif; other site 291331003722 Response regulator receiver domain; Region: Response_reg; pfam00072 291331003723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331003724 active site 291331003725 phosphorylation site [posttranslational modification] 291331003726 intermolecular recognition site; other site 291331003727 dimerization interface [polypeptide binding]; other site 291331003728 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 291331003729 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 291331003730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331003731 dimer interface [polypeptide binding]; other site 291331003732 phosphorylation site [posttranslational modification] 291331003733 Transposase domain (DUF772); Region: DUF772; cl12084 291331003734 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331003735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 291331003736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331003737 ATP binding site [chemical binding]; other site 291331003738 Mg2+ binding site [ion binding]; other site 291331003739 G-X-G motif; other site 291331003740 Response regulator receiver domain; Region: Response_reg; pfam00072 291331003741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331003742 active site 291331003743 phosphorylation site [posttranslational modification] 291331003744 intermolecular recognition site; other site 291331003745 dimerization interface [polypeptide binding]; other site 291331003746 putative transposase OrfB; Reviewed; Region: PHA02517 291331003747 Integrase core domain; Region: rve; cl01316 291331003748 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 291331003749 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 291331003750 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 291331003751 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 291331003752 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 291331003754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 291331003755 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 291331003756 Domain of unknown function (DUF955); Region: DUF955; cl01076 291331003757 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 291331003758 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 291331003759 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 291331003760 tetrameric interface [polypeptide binding]; other site 291331003761 NAD binding site [chemical binding]; other site 291331003762 catalytic residues [active] 291331003763 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 291331003764 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 291331003765 active site 291331003766 enoyl-CoA hydratase; Provisional; Region: PRK09076 291331003767 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 291331003768 substrate binding site [chemical binding]; other site 291331003769 oxyanion hole (OAH) forming residues; other site 291331003770 trimer interface [polypeptide binding]; other site 291331003771 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 291331003772 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 291331003773 substrate binding site [chemical binding]; other site 291331003774 oxyanion hole (OAH) forming residues; other site 291331003775 trimer interface [polypeptide binding]; other site 291331003776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331003777 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 291331003778 Cation efflux family; Region: Cation_efflux; cl00316 291331003779 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 291331003780 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 291331003781 substrate binding site [chemical binding]; other site 291331003782 oxyanion hole (OAH) forming residues; other site 291331003783 trimer interface [polypeptide binding]; other site 291331003784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331003785 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 291331003786 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 291331003787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 291331003788 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 291331003789 DNA binding residues [nucleotide binding] 291331003790 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 291331003791 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 291331003792 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 291331003793 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 291331003794 protein binding site [polypeptide binding]; other site 291331003795 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 291331003796 protein binding site [polypeptide binding]; other site 291331003797 GTP-binding protein LepA; Provisional; Region: PRK05433 291331003798 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 291331003799 G1 box; other site 291331003800 putative GEF interaction site [polypeptide binding]; other site 291331003801 GTP/Mg2+ binding site [chemical binding]; other site 291331003802 Switch I region; other site 291331003803 G2 box; other site 291331003804 G3 box; other site 291331003805 Switch II region; other site 291331003806 G4 box; other site 291331003807 G5 box; other site 291331003808 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 291331003809 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 291331003810 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 291331003811 signal peptidase I; Provisional; Region: PRK10861 291331003812 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 291331003813 Catalytic site [active] 291331003814 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 291331003815 ribonuclease III; Reviewed; Region: rnc; PRK00102 291331003816 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 291331003817 dimerization interface [polypeptide binding]; other site 291331003818 active site 291331003819 metal binding site [ion binding]; metal-binding site 291331003820 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 291331003821 dsRNA binding site [nucleotide binding]; other site 291331003822 GTPase Era; Reviewed; Region: era; PRK00089 291331003823 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 291331003824 G1 box; other site 291331003825 GTP/Mg2+ binding site [chemical binding]; other site 291331003826 Switch I region; other site 291331003827 G2 box; other site 291331003828 Switch II region; other site 291331003829 G3 box; other site 291331003830 G4 box; other site 291331003831 G5 box; other site 291331003832 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 291331003833 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 291331003834 Recombination protein O N terminal; Region: RecO_N; pfam11967 291331003835 Recombination protein O C terminal; Region: RecO_C; pfam02565 291331003836 Response regulator receiver domain; Region: Response_reg; pfam00072 291331003837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331003838 active site 291331003839 phosphorylation site [posttranslational modification] 291331003840 intermolecular recognition site; other site 291331003841 dimerization interface [polypeptide binding]; other site 291331003842 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 291331003843 TRAM domain; Region: TRAM; cl01282 291331003844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331003845 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 291331003846 putative active site [active] 291331003847 putative metal binding residues [ion binding]; other site 291331003848 signature motif; other site 291331003849 putative dimer interface [polypeptide binding]; other site 291331003850 putative phosphate binding site [ion binding]; other site 291331003851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331003852 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331003853 Transposase domain (DUF772); Region: DUF772; cl12084 291331003854 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 291331003855 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 291331003856 catalytic residues [active] 291331003857 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 291331003858 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 291331003859 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 291331003860 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 291331003861 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 291331003862 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 291331003863 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 291331003864 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 291331003865 DNA-binding site [nucleotide binding]; DNA binding site 291331003866 RNA-binding motif; other site 291331003868 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 291331003869 putative active site [active] 291331003870 putative metal binding site [ion binding]; other site 291331003871 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 291331003872 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 291331003873 ATP binding site [chemical binding]; other site 291331003874 putative Mg++ binding site [ion binding]; other site 291331003875 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331003876 nucleotide binding region [chemical binding]; other site 291331003877 ATP-binding site [chemical binding]; other site 291331003878 DEAD/H associated; Region: DEAD_assoc; pfam08494 291331003879 ATP-dependent DNA ligase; Validated; Region: PRK09247 291331003880 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 291331003881 active site 291331003882 DNA binding site [nucleotide binding] 291331003883 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 291331003884 DNA binding site [nucleotide binding] 291331003885 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 291331003886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 291331003887 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 291331003888 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 291331003889 CHASE3 domain; Region: CHASE3; cl05000 291331003890 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331003891 metal binding site [ion binding]; metal-binding site 291331003892 active site 291331003893 I-site; other site 291331003894 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 291331003895 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 291331003896 dimer interface [polypeptide binding]; other site 291331003897 active site 291331003898 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 291331003899 putative active site [active] 291331003900 catalytic triad [active] 291331003901 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 291331003902 Autotransporter beta-domain; Region: Autotransporter; cl02365 291331003903 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 291331003904 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 291331003905 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 291331003906 NAD binding site [chemical binding]; other site 291331003907 Phe binding site; other site 291331003908 Protein of unknown function DUF45; Region: DUF45; cl00636 291331003909 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 291331003910 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 291331003911 Mechanosensitive ion channel; Region: MS_channel; pfam00924 291331003912 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331003913 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331003914 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331003915 putative chaperone; Provisional; Region: PRK11678 291331003916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331003917 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331003918 Cation efflux family; Region: Cation_efflux; cl00316 291331003919 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 291331003920 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 291331003921 PhnA protein; Region: PhnA; pfam03831 291331003922 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 291331003923 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 291331003924 FMN binding site [chemical binding]; other site 291331003925 active site 291331003926 substrate binding site [chemical binding]; other site 291331003927 catalytic residue [active] 291331003928 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 291331003929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331003930 putative substrate translocation pore; other site 291331003931 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 291331003932 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 291331003933 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 291331003934 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 291331003935 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 291331003936 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 291331003937 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 291331003938 Predicted integral membrane protein [Function unknown]; Region: COG0392 291331003939 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 291331003940 Uncharacterized conserved protein [Function unknown]; Region: COG2898 291331003941 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 291331003942 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 291331003943 homotrimer interaction site [polypeptide binding]; other site 291331003944 putative active site [active] 291331003945 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 291331003946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331003947 S-adenosylmethionine binding site [chemical binding]; other site 291331003948 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 291331003949 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 291331003950 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 291331003951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331003952 S-adenosylmethionine binding site [chemical binding]; other site 291331003953 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 291331003954 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331003955 Fatty acid desaturase; Region: FA_desaturase; pfam00487 291331003956 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 291331003957 Di-iron ligands [ion binding]; other site 291331003958 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 291331003959 Anti-sigma-K factor rskA; Region: RskA; cl02208 291331003960 RNA polymerase sigma factor; Provisional; Region: PRK12534 291331003961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 291331003962 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 291331003963 DNA binding residues [nucleotide binding] 291331003964 ferredoxin; Provisional; Region: PRK08764 291331003965 Putative Fe-S cluster; Region: FeS; pfam04060 291331003966 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 291331003967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 291331003968 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 291331003969 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 291331003970 active site 291331003971 HIGH motif; other site 291331003972 KMSKS motif; other site 291331003973 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 291331003974 tRNA binding surface [nucleotide binding]; other site 291331003975 anticodon binding site; other site 291331003976 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 291331003977 putative tRNA-binding site [nucleotide binding]; other site 291331003978 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 291331003980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331003981 Integrase core domain; Region: rve; cl01316 291331003982 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 291331003983 Amino acid permease; Region: AA_permease; pfam00324 291331003984 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 291331003985 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 291331003986 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 291331003987 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 291331003988 Protein of unknown function (DUF502); Region: DUF502; cl01107 291331003989 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 291331003990 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331003991 Transposase domain (DUF772); Region: DUF772; cl12084 291331003992 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 291331003993 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 291331003994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331003995 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 291331003996 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 291331003997 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 291331003998 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 291331003999 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 291331004000 Walker A/P-loop; other site 291331004001 ATP binding site [chemical binding]; other site 291331004002 Q-loop/lid; other site 291331004003 ABC transporter signature motif; other site 291331004004 Walker B; other site 291331004005 D-loop; other site 291331004006 H-loop/switch region; other site 291331004007 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 291331004008 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331004009 N-terminal plug; other site 291331004010 ligand-binding site [chemical binding]; other site 291331004011 Transposase domain (DUF772); Region: DUF772; cl12084 291331004012 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 291331004013 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 291331004014 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 291331004015 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 291331004016 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 291331004017 generic binding surface II; other site 291331004018 generic binding surface I; other site 291331004019 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 291331004020 RNA/DNA hybrid binding site [nucleotide binding]; other site 291331004021 active site 291331004022 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 291331004023 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 291331004024 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 291331004025 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 291331004026 active site 291331004027 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 291331004028 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 291331004029 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 291331004030 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 291331004031 trimer interface [polypeptide binding]; other site 291331004032 active site 291331004033 UDP-GlcNAc binding site [chemical binding]; other site 291331004034 lipid binding site [chemical binding]; lipid-binding site 291331004035 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 291331004036 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 291331004037 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 291331004038 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 291331004039 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 291331004040 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 291331004041 Surface antigen; Region: Bac_surface_Ag; cl03097 291331004042 zinc metallopeptidase RseP; Provisional; Region: PRK10779 291331004043 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 291331004044 active site 291331004045 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 291331004046 protein binding site [polypeptide binding]; other site 291331004047 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 291331004048 putative substrate binding region [chemical binding]; other site 291331004049 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 291331004050 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 291331004051 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 291331004052 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 291331004053 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 291331004054 catalytic residue [active] 291331004055 putative FPP diphosphate binding site; other site 291331004056 putative FPP binding hydrophobic cleft; other site 291331004057 dimer interface [polypeptide binding]; other site 291331004058 putative IPP diphosphate binding site; other site 291331004059 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 291331004060 hinge region; other site 291331004061 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 291331004062 putative nucleotide binding site [chemical binding]; other site 291331004063 uridine monophosphate binding site [chemical binding]; other site 291331004064 homohexameric interface [polypeptide binding]; other site 291331004065 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 291331004066 elongation factor Ts; Provisional; Region: tsf; PRK09377 291331004067 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 291331004068 Elongation factor TS; Region: EF_TS; pfam00889 291331004069 Elongation factor TS; Region: EF_TS; pfam00889 291331004070 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 291331004071 rRNA interaction site [nucleotide binding]; other site 291331004072 S8 interaction site; other site 291331004073 putative laminin-1 binding site; other site 291331004074 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 291331004075 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 291331004076 Spore Coat Protein U domain; Region: SCPU; cl02253 291331004077 Spore Coat Protein U domain; Region: SCPU; cl02253 291331004078 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 291331004079 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 291331004080 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 291331004081 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 291331004082 Spore Coat Protein U domain; Region: SCPU; cl02253 291331004083 methionine aminopeptidase; Reviewed; Region: PRK07281 291331004084 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 291331004085 active site 291331004086 PII uridylyl-transferase; Provisional; Region: PRK04374 291331004087 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 291331004088 metal binding triad; other site 291331004089 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 291331004090 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 291331004091 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 291331004092 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 291331004093 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 291331004094 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 291331004095 active site 291331004096 substrate binding site [chemical binding]; other site 291331004097 trimer interface [polypeptide binding]; other site 291331004098 CoA binding site [chemical binding]; other site 291331004099 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 291331004100 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 291331004101 metal binding site [ion binding]; metal-binding site 291331004102 dimer interface [polypeptide binding]; other site 291331004103 asparagine synthetase B; Provisional; Region: asnB; PRK09431 291331004104 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 291331004105 active site 291331004106 dimer interface [polypeptide binding]; other site 291331004107 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 291331004108 Ligand Binding Site [chemical binding]; other site 291331004109 Molecular Tunnel; other site 291331004110 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 291331004111 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 291331004112 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331004113 N-terminal plug; other site 291331004114 ligand-binding site [chemical binding]; other site 291331004115 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 291331004116 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 291331004117 active site 291331004118 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 291331004119 Ferritin-like domain; Region: Ferritin; pfam00210 291331004120 heme binding site [chemical binding]; other site 291331004121 ferroxidase pore; other site 291331004122 ferroxidase diiron center [ion binding]; other site 291331004123 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 291331004124 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 291331004125 CAP-like domain; other site 291331004126 Active site [active] 291331004127 primary dimer interface [polypeptide binding]; other site 291331004128 Cupin domain; Region: Cupin_2; cl09118 291331004129 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 291331004130 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 291331004131 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 291331004132 Transcriptional regulators [Transcription]; Region: MarR; COG1846 291331004133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331004134 NodT family; Region: outer_NodT; TIGR01845 291331004135 Outer membrane efflux protein; Region: OEP; pfam02321 291331004136 Outer membrane efflux protein; Region: OEP; pfam02321 291331004137 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 291331004138 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 291331004139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331004140 putative substrate translocation pore; other site 291331004141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331004142 Beta-lactamase; Region: Beta-lactamase; cl01009 291331004143 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331004144 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331004145 Integrase core domain; Region: rve; cl01316 291331004146 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331004147 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 291331004148 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 291331004149 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 291331004150 TPP-binding site; other site 291331004151 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 291331004152 PYR/PP interface [polypeptide binding]; other site 291331004153 dimer interface [polypeptide binding]; other site 291331004154 TPP binding site [chemical binding]; other site 291331004155 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 291331004156 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 291331004157 active site 291331004158 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 291331004159 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 291331004160 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 291331004161 active site 291331004162 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 291331004163 Late embryogenesis abundant protein; Region: LEA_2; cl12118 291331004164 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 291331004165 SmpB-tmRNA interface; other site 291331004166 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 291331004167 putative coenzyme Q binding site [chemical binding]; other site 291331004168 Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096 291331004169 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 291331004170 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 291331004171 metal binding site 2 [ion binding]; metal-binding site 291331004172 putative DNA binding helix; other site 291331004173 metal binding site 1 [ion binding]; metal-binding site 291331004174 dimer interface [polypeptide binding]; other site 291331004175 structural Zn2+ binding site [ion binding]; other site 291331004176 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 291331004177 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 291331004178 Walker A/P-loop; other site 291331004179 ATP binding site [chemical binding]; other site 291331004180 Q-loop/lid; other site 291331004181 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 291331004182 ABC transporter signature motif; other site 291331004183 Walker B; other site 291331004184 D-loop; other site 291331004185 H-loop/switch region; other site 291331004186 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 291331004187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331004188 HrcA protein C terminal domain; Region: HrcA; pfam01628 291331004189 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 291331004190 dimer interface [polypeptide binding]; other site 291331004191 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 291331004192 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 291331004193 chaperone protein DnaJ; Provisional; Region: PRK10767 291331004194 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 291331004195 HSP70 interaction site [polypeptide binding]; other site 291331004196 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 291331004197 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 291331004198 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 291331004199 dimer interface [polypeptide binding]; other site 291331004200 pyridoxal binding site [chemical binding]; other site 291331004201 ATP binding site [chemical binding]; other site 291331004202 prephenate dehydrogenase; Provisional; Region: PRK08818 291331004203 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 291331004204 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331004205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331004206 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331004207 dimerization interface [polypeptide binding]; other site 291331004208 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 291331004209 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 291331004210 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 291331004211 Walker A/P-loop; other site 291331004212 ATP binding site [chemical binding]; other site 291331004213 Q-loop/lid; other site 291331004214 ABC transporter signature motif; other site 291331004215 Walker B; other site 291331004216 D-loop; other site 291331004217 H-loop/switch region; other site 291331004218 Uncharacterized conserved protein [Function unknown]; Region: COG1739 291331004219 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 291331004220 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 291331004221 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 291331004222 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 291331004223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331004224 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331004225 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 291331004226 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 291331004227 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 291331004228 E3 interaction surface; other site 291331004229 lipoyl attachment site [posttranslational modification]; other site 291331004230 e3 binding domain; Region: E3_binding; pfam02817 291331004231 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 291331004232 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 291331004233 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 291331004234 TPP-binding site [chemical binding]; other site 291331004235 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 291331004236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 291331004237 Coenzyme A binding pocket [chemical binding]; other site 291331004238 Cupin superfamily protein; Region: Cupin_4; pfam08007 291331004239 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 291331004240 protein binding site [polypeptide binding]; other site 291331004241 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 291331004242 adenylosuccinate lyase; Provisional; Region: PRK09285 291331004243 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 291331004244 tetramer interface [polypeptide binding]; other site 291331004245 active site 291331004246 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 291331004247 Domain of unknown function DUF21; Region: DUF21; pfam01595 291331004248 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 291331004249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331004250 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004251 Integrase core domain; Region: rve; cl01316 291331004252 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331004253 fumarate hydratase; Reviewed; Region: fumC; PRK00485 291331004254 Class II fumarases; Region: Fumarase_classII; cd01362 291331004255 active site 291331004256 tetramer interface [polypeptide binding]; other site 291331004257 Protein of unknown function (DUF2884); Region: DUF2884; cl08135 291331004258 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 291331004259 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 291331004260 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 291331004261 Walker A/P-loop; other site 291331004262 ATP binding site [chemical binding]; other site 291331004263 Q-loop/lid; other site 291331004264 ABC transporter signature motif; other site 291331004265 Walker B; other site 291331004266 D-loop; other site 291331004267 H-loop/switch region; other site 291331004268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 291331004269 DNA-binding site [nucleotide binding]; DNA binding site 291331004270 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 291331004271 catalytic residues [active] 291331004272 dimer interface [polypeptide binding]; other site 291331004273 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 291331004274 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 291331004275 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 291331004276 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 291331004277 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 291331004278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331004279 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 291331004280 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 291331004281 SlyX; Region: SlyX; cl01090 291331004282 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 291331004283 Transcriptional regulators [Transcription]; Region: PurR; COG1609 291331004284 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 291331004285 DNA binding site [nucleotide binding] 291331004286 domain linker motif; other site 291331004287 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 291331004288 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 291331004289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 291331004290 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 291331004291 putative substrate binding site [chemical binding]; other site 291331004292 putative ATP binding site [chemical binding]; other site 291331004293 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 291331004294 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 291331004295 dimerization interface [polypeptide binding]; other site 291331004296 putative active cleft [active] 291331004297 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 291331004298 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 291331004299 substrate binding pocket [chemical binding]; other site 291331004300 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 291331004301 B12 binding site [chemical binding]; other site 291331004302 cobalt ligand [ion binding]; other site 291331004303 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 291331004304 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 291331004305 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 291331004306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 291331004307 dimerization interface [polypeptide binding]; other site 291331004308 putative DNA binding site [nucleotide binding]; other site 291331004309 putative Zn2+ binding site [ion binding]; other site 291331004310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331004311 S-adenosylmethionine binding site [chemical binding]; other site 291331004312 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 291331004313 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 291331004314 active site 291331004315 PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...; Region: PAF_acetylesterase_like; cd01820 291331004316 active site 291331004317 catalytic triad [active] 291331004318 oxyanion hole [active] 291331004319 specificity pocket; other site 291331004320 PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...; Region: PAF_acetylesterase_like; cd01820 291331004321 active site 291331004322 catalytic triad [active] 291331004323 oxyanion hole [active] 291331004324 specificity pocket; other site 291331004325 ribonuclease R; Region: RNase_R; TIGR02063 291331004326 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 291331004327 RNB domain; Region: RNB; pfam00773 291331004328 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 291331004329 RNA binding site [nucleotide binding]; other site 291331004330 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331004331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004333 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 291331004334 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 291331004335 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 291331004336 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 291331004337 Transposase domain (DUF772); Region: DUF772; cl12084 291331004338 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331004339 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331004340 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331004341 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331004342 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331004344 Transposase domain (DUF772); Region: DUF772; cl12084 291331004345 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 291331004346 DNA-binding site [nucleotide binding]; DNA binding site 291331004347 RNA-binding motif; other site 291331004348 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331004349 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 291331004350 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331004351 Transposase domain (DUF772); Region: DUF772; cl12084 291331004352 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331004353 Transposase domain (DUF772); Region: DUF772; cl12084 291331004354 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331004355 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331004356 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331004357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004359 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331004360 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331004361 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331004362 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331004363 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331004364 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331004365 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331004366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331004367 Integrase core domain; Region: rve; cl01316 291331004368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004369 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331004370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004371 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331004372 Transposase domain (DUF772); Region: DUF772; cl12084 291331004373 Integrase core domain; Region: rve; cl01316 291331004374 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331004375 Gram-negative bacterial tonB protein; Region: TonB; cl10048 291331004376 Gram-negative bacterial tonB protein; Region: TonB; cl10048 291331004377 seryl-tRNA synthetase; Provisional; Region: PRK05431 291331004378 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 291331004379 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 291331004380 dimer interface [polypeptide binding]; other site 291331004381 active site 291331004382 motif 1; other site 291331004383 motif 2; other site 291331004384 motif 3; other site 291331004385 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331004386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004388 Transposase domain (DUF772); Region: DUF772; cl12084 291331004389 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331004390 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 291331004391 LysR family transcriptional regulator; Provisional; Region: PRK14997 291331004392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331004393 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 291331004394 putative effector binding pocket; other site 291331004395 putative dimerization interface [polypeptide binding]; other site 291331004396 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004397 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004398 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004399 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004400 Integrase core domain; Region: rve; cl01316 291331004401 Transposase domain (DUF772); Region: DUF772; cl12084 291331004402 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004403 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004404 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004405 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331004406 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 291331004407 Peptidase C13 family; Region: Peptidase_C13; cl02159 291331004408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 291331004409 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 291331004410 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 291331004411 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 291331004412 intersubunit interface [polypeptide binding]; other site 291331004413 active site 291331004414 Zn2+ binding site [ion binding]; other site 291331004415 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 291331004416 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 291331004417 Amino acid permease; Region: AA_permease; pfam00324 291331004418 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 291331004419 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 291331004420 nudix motif; other site 291331004421 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 291331004422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331004423 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 291331004424 L-serine binding site [chemical binding]; other site 291331004425 ACT domain interface; other site 291331004426 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 291331004427 FAD binding domain; Region: FAD_binding_4; pfam01565 291331004428 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 291331004429 Cytochrome C biogenesis protein; Region: CcmH; cl01179 291331004430 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 291331004431 catalytic residues [active] 291331004432 central insert; other site 291331004433 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 291331004434 CcmE; Region: CcmE; cl00994 291331004435 CcmB protein; Region: CcmB; cl01016 291331004436 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13543 291331004437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331004438 Walker A/P-loop; other site 291331004439 ATP binding site [chemical binding]; other site 291331004440 Q-loop/lid; other site 291331004441 ABC transporter signature motif; other site 291331004442 Walker B; other site 291331004443 D-loop; other site 291331004444 H-loop/switch region; other site 291331004445 methionine aminotransferase; Validated; Region: PRK09082 291331004446 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 291331004447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331004448 homodimer interface [polypeptide binding]; other site 291331004449 catalytic residue [active] 291331004450 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 291331004451 active site 291331004452 catalytic triad [active] 291331004453 dimer interface [polypeptide binding]; other site 291331004454 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331004455 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331004456 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 291331004457 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 291331004458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 291331004459 RNA binding surface [nucleotide binding]; other site 291331004460 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 291331004461 active site 291331004462 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 291331004463 ScpA/B protein; Region: ScpA_ScpB; cl00598 291331004464 YCII-related domain; Region: YCII; cl00999 291331004465 BolA-like protein; Region: BolA; cl00386 291331004466 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331004467 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331004468 Integrase core domain; Region: rve; cl01316 291331004469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 291331004470 Uncharacterized protein conserved in bacteria (DUF2329); Region: DUF2329; pfam10091 291331004471 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 291331004472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331004473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 291331004474 dimer interface [polypeptide binding]; other site 291331004475 conserved gate region; other site 291331004476 putative PBP binding loops; other site 291331004477 ABC-ATPase subunit interface; other site 291331004478 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 291331004479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 291331004480 dimer interface [polypeptide binding]; other site 291331004481 conserved gate region; other site 291331004482 putative PBP binding loops; other site 291331004483 ABC-ATPase subunit interface; other site 291331004484 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 291331004485 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 291331004486 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 291331004487 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 291331004488 TraB family; Region: TraB; cl12050 291331004489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331004490 N-carbamolyputrescine amidase; Region: PLN02747 291331004491 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 291331004492 putative active site; other site 291331004493 catalytic triad [active] 291331004494 putative dimer interface [polypeptide binding]; other site 291331004495 agmatine deiminase; Region: agmatine_aguA; TIGR03380 291331004496 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 291331004497 cytidylate kinase; Provisional; Region: cmk; PRK00023 291331004498 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 291331004499 CMP-binding site; other site 291331004500 The sites determining sugar specificity; other site 291331004501 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 291331004502 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 291331004503 RNA binding site [nucleotide binding]; other site 291331004504 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 291331004505 RNA binding site [nucleotide binding]; other site 291331004506 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 291331004507 RNA binding site [nucleotide binding]; other site 291331004508 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 291331004509 RNA binding site [nucleotide binding]; other site 291331004510 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 291331004511 RNA binding site [nucleotide binding]; other site 291331004512 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 291331004513 RNA binding site [nucleotide binding]; other site 291331004514 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 291331004515 IHF dimer interface [polypeptide binding]; other site 291331004516 IHF - DNA interface [nucleotide binding]; other site 291331004517 tetratricopeptide repeat protein; Provisional; Region: PRK11788 291331004518 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331004519 binding surface 291331004520 TPR motif; other site 291331004521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331004522 binding surface 291331004523 TPR motif; other site 291331004524 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine...; Region: GT_WbpL_WbcO_like; cd06854 291331004525 Mg++ binding site [ion binding]; other site 291331004526 putative catalytic motif [active] 291331004527 putative substrate binding site [chemical binding]; other site 291331004528 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 291331004529 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 291331004530 NAD(P) binding site [chemical binding]; other site 291331004531 homodimer interface [polypeptide binding]; other site 291331004532 substrate binding site [chemical binding]; other site 291331004533 active site 291331004534 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 291331004535 active site 291331004536 tetramer interface [polypeptide binding]; other site 291331004538 Transposase domain (DUF772); Region: DUF772; cl12084 291331004539 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 291331004540 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 291331004541 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 291331004542 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 291331004543 homodimer interface [polypeptide binding]; other site 291331004544 NADP binding site [chemical binding]; other site 291331004545 substrate binding site [chemical binding]; other site 291331004546 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 291331004547 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 291331004548 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 291331004549 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 291331004550 active site 291331004551 GMP synthase; Reviewed; Region: guaA; PRK00074 291331004552 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 291331004553 AMP/PPi binding site [chemical binding]; other site 291331004554 candidate oxyanion hole; other site 291331004555 catalytic triad [active] 291331004556 potential glutamine specificity residues [chemical binding]; other site 291331004557 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 291331004558 ATP Binding subdomain [chemical binding]; other site 291331004559 Ligand Binding sites [chemical binding]; other site 291331004560 Dimerization subdomain; other site 291331004561 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 291331004562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 291331004563 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 291331004564 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 291331004565 Transcriptional regulator [Transcription]; Region: LysR; COG0583 291331004566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331004567 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 291331004568 dimerization interface [polypeptide binding]; other site 291331004569 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 291331004570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331004571 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 291331004572 putative dimerization interface [polypeptide binding]; other site 291331004573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331004574 active site 291331004575 phosphorylation site [posttranslational modification] 291331004576 intermolecular recognition site; other site 291331004577 dimerization interface [polypeptide binding]; other site 291331004578 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 291331004579 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 291331004580 manganese transport regulator MntR; Provisional; Region: PRK11050 291331004581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331004582 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 291331004583 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 291331004584 nucleoside/Zn binding site; other site 291331004585 dimer interface [polypeptide binding]; other site 291331004586 catalytic motif [active] 291331004587 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 291331004588 putative active site [active] 291331004589 putative substrate binding site [chemical binding]; other site 291331004590 catalytic site [active] 291331004591 dimer interface [polypeptide binding]; other site 291331004592 Mechanosensitive ion channel; Region: MS_channel; pfam00924 291331004593 phosphoenolpyruvate synthase; Validated; Region: PRK06464 291331004594 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 291331004595 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 291331004596 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 291331004597 Domain of unknown function (DUF299); Region: DUF299; cl00780 291331004598 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 291331004599 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 291331004600 putative active site [active] 291331004601 nucleotide binding site [chemical binding]; other site 291331004602 nudix motif; other site 291331004603 putative metal binding site [ion binding]; other site 291331004604 Transposase domain (DUF772); Region: DUF772; cl12084 291331004605 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331004606 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331004607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331004608 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 291331004609 NAD(P) binding site [chemical binding]; other site 291331004610 active site 291331004611 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 291331004612 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 291331004613 PhaC subunit; Region: PHA_synth_III_C; TIGR01836 291331004614 PspC domain; Region: PspC; cl00864 291331004615 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 291331004616 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 291331004617 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 291331004618 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 291331004619 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 291331004620 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 291331004621 RNA binding site [nucleotide binding]; other site 291331004622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331004623 Integrase core domain; Region: rve; cl01316 291331004624 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 291331004625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331004626 active site 291331004627 phosphorylation site [posttranslational modification] 291331004628 intermolecular recognition site; other site 291331004629 dimerization interface [polypeptide binding]; other site 291331004630 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 291331004631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 291331004632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331004633 ATP binding site [chemical binding]; other site 291331004634 Mg2+ binding site [ion binding]; other site 291331004635 G-X-G motif; other site 291331004636 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 291331004637 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 291331004638 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 291331004639 active site 291331004640 metabolite-proton symporter; Region: 2A0106; TIGR00883 291331004641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331004642 putative substrate translocation pore; other site 291331004643 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331004644 Integrase core domain; Region: rve; cl01316 291331004645 EamA-like transporter family; Region: EamA; cl01037 291331004646 EamA-like transporter family; Region: EamA; cl01037 291331004647 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 291331004648 FAD binding domain; Region: FAD_binding_4; pfam01565 291331004649 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 291331004650 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 291331004651 quinone interaction residues [chemical binding]; other site 291331004652 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 291331004653 active site 291331004654 catalytic residues [active] 291331004655 FMN binding site [chemical binding]; other site 291331004656 substrate binding site [chemical binding]; other site 291331004657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331004658 S-adenosylmethionine binding site [chemical binding]; other site 291331004659 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 291331004660 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 291331004661 tetrameric interface [polypeptide binding]; other site 291331004662 NAD binding site [chemical binding]; other site 291331004663 catalytic residues [active] 291331004664 TspO/MBR family; Region: TspO_MBR; cl01379 291331004665 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 291331004666 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli AKI-...; Region: AAK_AK-HSDH; cd04257 291331004667 putative catalytic residues [active] 291331004668 putative nucleotide binding site [chemical binding]; other site 291331004669 putative aspartate binding site [chemical binding]; other site 291331004670 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 291331004671 dimer interface [polypeptide binding]; other site 291331004672 putative threonine allosteric regulatory site; other site 291331004673 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 291331004674 putative threonine allosteric regulatory site; other site 291331004675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331004676 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 291331004677 homoserine kinase; Provisional; Region: PRK01212 291331004678 EthD protein; Region: EthD; cl06234 291331004679 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 291331004680 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 291331004681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331004682 catalytic residue [active] 291331004684 histidyl-tRNA synthetase; Region: hisS; TIGR00442 291331004685 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 291331004686 dimer interface [polypeptide binding]; other site 291331004687 motif 1; other site 291331004688 active site 291331004689 motif 2; other site 291331004690 motif 3; other site 291331004691 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 291331004692 anticodon binding site; other site 291331004693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004695 Trp repressor protein; Region: Trp_repressor; cl01121 291331004696 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 291331004697 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331004698 HisG, C-terminal domain; Region: HisG_C; cl06867 291331004699 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 291331004700 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 291331004701 NAD binding site [chemical binding]; other site 291331004702 dimerization interface [polypeptide binding]; other site 291331004703 product binding site; other site 291331004704 substrate binding site [chemical binding]; other site 291331004705 zinc binding site [ion binding]; other site 291331004706 catalytic residues [active] 291331004707 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 291331004708 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 291331004709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331004710 homodimer interface [polypeptide binding]; other site 291331004711 catalytic residue [active] 291331004712 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 291331004713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 291331004714 active site 291331004715 motif I; other site 291331004716 motif II; other site 291331004717 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 291331004718 putative active site pocket [active] 291331004719 4-fold oligomerization interface [polypeptide binding]; other site 291331004720 metal binding residues [ion binding]; metal-binding site 291331004721 3-fold/trimer interface [polypeptide binding]; other site 291331004722 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 291331004723 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 291331004724 putative active site [active] 291331004725 oxyanion strand; other site 291331004726 catalytic triad [active] 291331004727 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 291331004728 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 291331004729 catalytic residues [active] 291331004730 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 291331004731 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 291331004732 substrate binding site [chemical binding]; other site 291331004733 glutamase interaction surface [polypeptide binding]; other site 291331004734 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 291331004735 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 291331004736 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 291331004737 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004738 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004739 Replication initiation factor; Region: Rep_trans; pfam02486 291331004740 Zonular occludens toxin (Zot); Region: Zot; cl01706 291331004741 BCCT family transporter; Region: BCCT; cl00569 291331004742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004743 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331004744 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331004745 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004746 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004747 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004748 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004749 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004750 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004752 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004753 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004754 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331004755 Integrase core domain; Region: rve; cl01316 291331004756 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331004757 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331004758 Integrase core domain; Region: rve; cl01316 291331004759 Transposase domain (DUF772); Region: DUF772; cl12084 291331004760 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331004761 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331004762 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331004763 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 291331004764 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 291331004765 RHS Repeat; Region: RHS_repeat; cl11982 291331004766 RHS Repeat; Region: RHS_repeat; cl11982 291331004767 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 291331004768 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 291331004769 active site 291331004770 metal binding site [ion binding]; metal-binding site 291331004771 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 291331004772 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 291331004773 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 291331004774 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 291331004775 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 291331004776 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 291331004777 Low molecular weight phosphatase family; Region: LMWPc; cd00115 291331004778 Active site [active] 291331004779 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 291331004780 Ligand binding site [chemical binding]; other site 291331004781 oligomer interface [polypeptide binding]; other site 291331004782 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 291331004783 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 291331004784 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 291331004785 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 291331004786 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331004787 Walker A/P-loop; other site 291331004788 ATP binding site [chemical binding]; other site 291331004789 Q-loop/lid; other site 291331004790 ABC transporter signature motif; other site 291331004791 Walker B; other site 291331004792 D-loop; other site 291331004793 H-loop/switch region; other site 291331004794 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 291331004795 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 291331004796 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 291331004797 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 291331004798 Competence protein; Region: Competence; cl00471 291331004799 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 291331004800 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331004801 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331004802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331004803 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 291331004804 active site 291331004805 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 291331004806 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 291331004807 Walker A/P-loop; other site 291331004808 ATP binding site [chemical binding]; other site 291331004809 Q-loop/lid; other site 291331004810 ABC transporter signature motif; other site 291331004811 Walker B; other site 291331004812 D-loop; other site 291331004813 H-loop/switch region; other site 291331004814 LolC/E family; Region: lolCE; TIGR02212 291331004815 FtsX-like permease family; Region: FtsX; pfam02687 291331004816 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 291331004817 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 291331004818 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 291331004819 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331004820 domain; Region: Succ_DH_flav_C; pfam02910 291331004821 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the...; Region: SQR_TypeC_SdhD_like; cd03495 291331004822 putative SdhC subunit interface [polypeptide binding]; other site 291331004823 putative proximal heme binding site [chemical binding]; other site 291331004824 putative Iron-sulfur protein interface [polypeptide binding]; other site 291331004825 putative proximal quinone binding site; other site 291331004826 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 291331004827 Iron-sulfur protein interface; other site 291331004828 proximal quinone binding site [chemical binding]; other site 291331004829 SdhD (CybS) interface [polypeptide binding]; other site 291331004830 proximal heme binding site [chemical binding]; other site 291331004832 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 291331004833 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 291331004834 Walker A/P-loop; other site 291331004835 ATP binding site [chemical binding]; other site 291331004836 Q-loop/lid; other site 291331004837 ABC transporter signature motif; other site 291331004838 Walker B; other site 291331004839 D-loop; other site 291331004840 H-loop/switch region; other site 291331004841 TOBE domain; Region: TOBE_2; cl01440 291331004842 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 291331004843 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 291331004844 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 291331004845 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 291331004846 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 291331004847 putative active site [active] 291331004848 Dehydratase family; Region: ILVD_EDD; cl00340 291331004849 6-phosphogluconate dehydratase; Region: edd; TIGR01196 291331004850 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 291331004851 Transposase domain (DUF772); Region: DUF772; cl12084 291331004852 transcriptional regulator NanR; Provisional; Region: PRK03837 291331004853 response regulator; Provisional; Region: PRK13435 291331004854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 291331004855 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 291331004856 GAF domain; Region: GAF; cl00853 291331004857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 291331004858 PAS fold; Region: PAS_3; pfam08447 291331004859 putative active site [active] 291331004860 heme pocket [chemical binding]; other site 291331004861 PAS domain S-box; Region: sensory_box; TIGR00229 291331004862 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 291331004863 putative active site [active] 291331004864 heme pocket [chemical binding]; other site 291331004865 GAF domain; Region: GAF; cl00853 291331004866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331004867 dimer interface [polypeptide binding]; other site 291331004868 phosphorylation site [posttranslational modification] 291331004869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331004870 ATP binding site [chemical binding]; other site 291331004871 Mg2+ binding site [ion binding]; other site 291331004872 G-X-G motif; other site 291331004873 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 291331004874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331004875 active site 291331004876 phosphorylation site [posttranslational modification] 291331004877 intermolecular recognition site; other site 291331004878 dimerization interface [polypeptide binding]; other site 291331004879 Integrase core domain; Region: rve; cl01316 291331004880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331004881 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331004882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331004883 metal binding site [ion binding]; metal-binding site 291331004884 active site 291331004885 I-site; other site 291331004886 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331004887 metal binding site [ion binding]; metal-binding site 291331004888 active site 291331004889 I-site; other site 291331004890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331004891 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among Gram-...; Region: OMPLA; cd00541 291331004892 dimerization interface [polypeptide binding]; other site 291331004893 substrate binding site [chemical binding]; other site 291331004894 active site 291331004895 calcium binding site [ion binding]; other site 291331004896 GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188 291331004897 dimer interface [polypeptide binding]; other site 291331004898 N-terminal domain interface [polypeptide binding]; other site 291331004899 substrate binding pocket (H-site) [chemical binding]; other site 291331004900 putative fumarate hydratase; Provisional; Region: PRK15392 291331004901 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 291331004902 Fumarase C-terminus; Region: Fumerase_C; cl00795 291331004903 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 291331004904 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331004905 Walker A/P-loop; other site 291331004906 ATP binding site [chemical binding]; other site 291331004907 Q-loop/lid; other site 291331004908 ABC transporter signature motif; other site 291331004909 Walker B; other site 291331004910 D-loop; other site 291331004911 H-loop/switch region; other site 291331004912 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 291331004913 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 291331004914 FAD binding pocket [chemical binding]; other site 291331004915 FAD binding motif [chemical binding]; other site 291331004916 phosphate binding motif [ion binding]; other site 291331004917 beta-alpha-beta structure motif; other site 291331004918 NAD binding pocket [chemical binding]; other site 291331004919 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 291331004920 catalytic residues [active] 291331004921 dimer interface [polypeptide binding]; other site 291331004922 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 291331004923 Zn binding site [ion binding]; other site 291331004924 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 291331004925 active site 291331004926 catalytic triad [active] 291331004927 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 291331004928 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 291331004929 DNA binding residues [nucleotide binding] 291331004930 Anti-sigma-K factor rskA; Region: RskA; cl02208 291331004931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331004932 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 291331004933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331004934 Rhomboid family; Region: Rhomboid; cl11446 291331004935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 291331004936 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_1_4; cd06241 291331004937 putative active site [active] 291331004938 Zn-binding site [ion binding]; other site 291331004939 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 291331004940 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 291331004941 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 291331004942 GAF domain; Region: GAF; cl00853 291331004943 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 291331004944 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 291331004945 Sodium:solute symporter family; Region: SSF; cl00456 291331004946 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 291331004947 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 291331004948 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 291331004949 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 291331004950 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331004951 Phd_YefM; Region: PhdYeFM; cl09153 291331004952 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 291331004953 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 291331004954 active site 291331004955 dimer interface [polypeptide binding]; other site 291331004956 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 291331004957 dimer interface [polypeptide binding]; other site 291331004958 active site 291331004959 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 291331004960 tetramerization interface [polypeptide binding]; other site 291331004961 active site 291331004962 Pantoate-beta-alanine ligase; Region: PanC; cd00560 291331004963 pantoate--beta-alanine ligase; Region: panC; TIGR00018 291331004964 active site 291331004965 ATP-binding site [chemical binding]; other site 291331004966 pantoate-binding site; other site 291331004967 HXXH motif; other site 291331004968 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 291331004969 oligomerization interface [polypeptide binding]; other site 291331004970 active site 291331004971 metal binding site [ion binding]; metal-binding site 291331004972 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 291331004973 catalytic center binding site [active] 291331004974 ATP binding site [chemical binding]; other site 291331004975 poly(A) polymerase; Region: pcnB; TIGR01942 291331004976 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 291331004977 active site 291331004978 NTP binding site [chemical binding]; other site 291331004979 metal binding triad [ion binding]; metal-binding site 291331004980 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 291331004981 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 291331004982 Uncharacterized ACR, COG1469; Region: DUF198; cl00642 291331004983 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 291331004984 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 291331004985 active site 291331004986 metal binding site [ion binding]; metal-binding site 291331004987 Transposase domain (DUF772); Region: DUF772; cl12084 291331004988 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 291331004989 putative active site [active] 291331004990 catalytic triad [active] 291331004991 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 291331004992 catalytic residues [active] 291331004993 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 291331004994 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 291331004995 Autotransporter beta-domain; Region: Autotransporter; cl02365 291331004996 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 291331004997 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 291331004998 NodT family; Region: outer_NodT; TIGR01845 291331004999 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331005000 dimer interface [polypeptide binding]; other site 291331005001 phosphorylation site [posttranslational modification] 291331005002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331005003 ATP binding site [chemical binding]; other site 291331005004 Mg2+ binding site [ion binding]; other site 291331005005 G-X-G motif; other site 291331005006 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 291331005007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331005008 active site 291331005009 phosphorylation site [posttranslational modification] 291331005010 intermolecular recognition site; other site 291331005011 dimerization interface [polypeptide binding]; other site 291331005012 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 291331005013 DNA binding residues [nucleotide binding] 291331005014 dimerization interface [polypeptide binding]; other site 291331005015 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 291331005016 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 291331005017 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 291331005018 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 291331005019 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 291331005020 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 291331005021 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 291331005022 Autotransporter beta-domain; Region: Autotransporter; cl02365 291331005023 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331005024 Transposase domain (DUF772); Region: DUF772; cl12084 291331005025 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331005026 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331005027 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 291331005028 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 291331005029 hinge; other site 291331005030 active site 291331005031 Chorismate mutase type II; Region: CM_2; cl00693 291331005032 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 291331005033 Prephenate dehydratase; Region: PDT; pfam00800 291331005034 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 291331005035 putative L-Phe binding site [chemical binding]; other site 291331005036 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291331005037 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331005038 catalytic residue [active] 291331005039 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 291331005040 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 291331005041 Moco binding site; other site 291331005042 metal coordination site [ion binding]; other site 291331005043 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 291331005044 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 291331005045 phosphopeptide binding site; other site 291331005046 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 291331005047 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 291331005048 Restriction endonuclease; Region: Mrr_cat; cl00747 291331005049 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 291331005050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 291331005051 DNA-binding site [nucleotide binding]; DNA binding site 291331005052 UTRA domain; Region: UTRA; cl06649 291331005053 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 291331005054 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 291331005055 active site 291331005056 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 291331005057 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 291331005058 active site 291331005059 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 291331005060 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 291331005061 active sites [active] 291331005062 tetramer interface [polypeptide binding]; other site 291331005063 N-formylglutamate amidohydrolase; Region: FGase; cl01522 291331005064 urocanate hydratase; Provisional; Region: PRK05414 291331005065 urocanate hydratase; Region: hutU; TIGR01228 291331005066 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 291331005067 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331005068 DNA gyrase subunit A; Validated; Region: PRK05560 291331005069 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 291331005070 CAP-like domain; other site 291331005071 Active site [active] 291331005072 primary dimer interface [polypeptide binding]; other site 291331005073 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 291331005074 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 291331005075 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 291331005076 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 291331005077 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 291331005078 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 291331005079 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 291331005080 Protein of unknown function (DUF3011); Region: DUF3011; pfam11218 291331005081 lysyl-tRNA synthetase-like protein GenX; Region: genX; TIGR00462 291331005082 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 291331005083 motif 1; other site 291331005084 dimer interface [polypeptide binding]; other site 291331005085 active site 291331005086 motif 2; other site 291331005087 motif 3; other site 291331005088 Ligase N family; Region: LIGANc; smart00532 291331005089 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 291331005090 nucleotide binding pocket [chemical binding]; other site 291331005091 K-X-D-G motif; other site 291331005092 catalytic site [active] 291331005093 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 291331005094 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 291331005095 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 291331005096 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 291331005097 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 291331005098 Dimer interface [polypeptide binding]; other site 291331005099 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291331005100 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 291331005101 FtsZ protein binding site [polypeptide binding]; other site 291331005102 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 291331005103 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 291331005104 Walker A/P-loop; other site 291331005105 ATP binding site [chemical binding]; other site 291331005106 Q-loop/lid; other site 291331005107 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 291331005108 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 291331005109 ABC transporter signature motif; other site 291331005110 Walker B; other site 291331005111 D-loop; other site 291331005112 H-loop/switch region; other site 291331005113 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 291331005114 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 291331005115 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 291331005116 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 291331005117 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 291331005118 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 291331005119 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 291331005120 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 291331005121 putative dimer interface [polypeptide binding]; other site 291331005122 putative anticodon binding site; other site 291331005123 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 291331005124 homodimer interface [polypeptide binding]; other site 291331005125 motif 1; other site 291331005126 motif 2; other site 291331005127 active site 291331005128 motif 3; other site 291331005129 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 291331005130 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 291331005131 active site clefts [active] 291331005132 zinc binding site [ion binding]; other site 291331005133 dimer interface [polypeptide binding]; other site 291331005134 Cupin domain; Region: Cupin_2; cl09118 291331005135 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 291331005136 kynureninase; Region: kynureninase; TIGR01814 291331005137 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291331005138 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331005139 catalytic residue [active] 291331005140 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 291331005141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331005142 exonuclease I; Provisional; Region: sbcB; PRK11779 291331005143 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 291331005144 active site 291331005145 substrate binding site [chemical binding]; other site 291331005146 catalytic site [active] 291331005147 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 291331005148 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 291331005149 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 291331005150 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 291331005151 active site 291331005152 catalytic tetrad [active] 291331005153 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 291331005154 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 291331005156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331005157 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331005158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331005159 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 291331005160 THUMP domain; Region: THUMP; cl12076 291331005161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331005162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331005163 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331005164 Walker A/P-loop; other site 291331005165 ATP binding site [chemical binding]; other site 291331005166 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 291331005167 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331005168 Walker A/P-loop; other site 291331005169 ATP binding site [chemical binding]; other site 291331005170 Q-loop/lid; other site 291331005171 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 291331005172 ABC transporter signature motif; other site 291331005173 Walker B; other site 291331005174 D-loop; other site 291331005175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331005176 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 291331005177 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 291331005178 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 291331005179 substrate binding site [chemical binding]; other site 291331005180 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 291331005181 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 291331005182 active site residue [active] 291331005183 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 291331005184 active site residue [active] 291331005185 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 291331005186 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 291331005187 putative active site [active] 291331005188 putative CoA binding site [chemical binding]; other site 291331005189 nudix motif; other site 291331005190 metal binding site [ion binding]; metal-binding site 291331005191 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 291331005192 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 291331005193 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 291331005194 substrate binding site [chemical binding]; other site 291331005195 oxyanion hole (OAH) forming residues; other site 291331005196 trimer interface [polypeptide binding]; other site 291331005197 endonuclease III; Provisional; Region: PRK10702 291331005198 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 291331005199 minor groove reading motif; other site 291331005200 helix-hairpin-helix signature motif; other site 291331005201 substrate binding pocket [chemical binding]; other site 291331005202 active site 291331005203 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 291331005204 dimer interface [polypeptide binding]; other site 291331005205 active site clefts [active] 291331005206 zinc binding site [ion binding]; other site 291331005207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331005208 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 291331005209 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331005210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331005211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 291331005212 dimer interface [polypeptide binding]; other site 291331005213 conserved gate region; other site 291331005214 putative PBP binding loops; other site 291331005215 ABC-ATPase subunit interface; other site 291331005216 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 291331005217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 291331005218 dimer interface [polypeptide binding]; other site 291331005219 conserved gate region; other site 291331005220 putative PBP binding loops; other site 291331005221 ABC-ATPase subunit interface; other site 291331005222 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 291331005223 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 291331005224 Walker A/P-loop; other site 291331005225 ATP binding site [chemical binding]; other site 291331005226 Q-loop/lid; other site 291331005227 ABC transporter signature motif; other site 291331005228 Walker B; other site 291331005229 D-loop; other site 291331005230 H-loop/switch region; other site 291331005231 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 291331005232 PhoU domain; Region: PhoU; pfam01895 291331005233 PhoU domain; Region: PhoU; pfam01895 291331005234 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 291331005235 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 291331005236 dimer interface [polypeptide binding]; other site 291331005237 putative active site [active] 291331005238 putative substrate binding site [chemical binding]; other site 291331005239 catalytic site [active] 291331005240 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331005241 Transposase domain (DUF772); Region: DUF772; cl12084 291331005242 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331005243 Transposase, Mutator family; Region: Transposase_mut; pfam00872 291331005244 MULE transposase domain; Region: MULE; pfam10551 291331005245 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 291331005246 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 291331005247 Protein export membrane protein; Region: SecD_SecF; cl14618 291331005248 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 291331005249 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 291331005250 Protein export membrane protein; Region: SecD_SecF; cl14618 291331005251 Preprotein translocase subunit; Region: YajC; cl00806 291331005252 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 291331005253 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 291331005254 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 291331005255 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 291331005256 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331005257 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291331005258 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 291331005259 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331005260 catalytic residue [active] 291331005261 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 291331005262 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 291331005263 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 291331005264 Transposase domain (DUF772); Region: DUF772; cl12084 291331005265 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331005266 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331005267 Transposase domain (DUF772); Region: DUF772; cl12084 291331005268 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331005269 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 291331005270 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331005271 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331005272 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331005273 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 291331005274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331005275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331005276 Integrase core domain; Region: rve; cl01316 291331005277 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 291331005278 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 291331005279 hypothetical protein; Provisional; Region: PRK13795 291331005280 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 291331005281 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 291331005282 active site 291331005283 (T/H)XGH motif; other site 291331005284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331005285 S-adenosylmethionine binding site [chemical binding]; other site 291331005286 heat shock protein 90; Provisional; Region: PRK05218 291331005287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331005288 ATP binding site [chemical binding]; other site 291331005289 Mg2+ binding site [ion binding]; other site 291331005290 G-X-G motif; other site 291331005291 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331005292 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 291331005293 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 291331005294 active site residue [active] 291331005295 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 291331005296 ATP binding site [chemical binding]; other site 291331005297 substrate interface [chemical binding]; other site 291331005298 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331005299 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331005300 Transposase domain (DUF772); Region: DUF772; cl12084 291331005301 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331005302 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331005303 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331005304 Integrase core domain; Region: rve; cl01316 291331005305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331005306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331005307 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 291331005308 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 291331005309 dimer interface [polypeptide binding]; other site 291331005310 putative functional site; other site 291331005311 putative MPT binding site; other site 291331005312 GTP-binding protein Der; Reviewed; Region: PRK00093 291331005313 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 291331005314 G1 box; other site 291331005315 GTP/Mg2+ binding site [chemical binding]; other site 291331005316 Switch I region; other site 291331005317 G2 box; other site 291331005318 Switch II region; other site 291331005319 G3 box; other site 291331005320 G4 box; other site 291331005321 G5 box; other site 291331005322 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 291331005323 G1 box; other site 291331005324 GTP/Mg2+ binding site [chemical binding]; other site 291331005325 Switch I region; other site 291331005326 G2 box; other site 291331005327 G3 box; other site 291331005328 Switch II region; other site 291331005329 G4 box; other site 291331005330 G5 box; other site 291331005331 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 291331005332 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 291331005333 Trp docking motif; other site 291331005334 active site 291331005335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 291331005336 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 291331005337 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 291331005338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 291331005339 cytoskeletal protein RodZ; Provisional; Region: PRK10856 291331005340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331005341 binding surface 291331005342 TPR motif; other site 291331005343 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331005344 binding surface 291331005345 TPR motif; other site 291331005346 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 291331005347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 291331005348 FeS/SAM binding site; other site 291331005349 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 291331005350 active site 291331005351 multimer interface [polypeptide binding]; other site 291331005352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 291331005353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 291331005354 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 291331005355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331005356 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 291331005357 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 291331005358 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 291331005359 substrate binding site [chemical binding]; other site 291331005360 oxyanion hole (OAH) forming residues; other site 291331005361 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 291331005362 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 291331005363 dimer interface [polypeptide binding]; other site 291331005364 active site 291331005365 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 291331005366 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 291331005367 putative Cl- selectivity filter; other site 291331005368 putative pore gating glutamate residue; other site 291331005369 CrcB-like protein; Region: CRCB; cl09114 291331005370 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 291331005371 recombination factor protein RarA; Reviewed; Region: PRK13342 291331005372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331005373 Walker A motif; other site 291331005374 ATP binding site [chemical binding]; other site 291331005375 Walker B motif; other site 291331005376 arginine finger; other site 291331005377 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 291331005378 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 291331005379 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 291331005380 Domain of Unknown Function with PDB structure; Region: DUF3857; pfam12969 291331005381 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 291331005382 DNA translocase FtsK; Provisional; Region: PRK10263 291331005383 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 291331005384 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331005385 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 291331005386 thioredoxin reductase; Provisional; Region: PRK10262 291331005387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331005388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331005389 FemAB family; Region: FemAB; cl11444 291331005390 Protein of unknown function, DUF482; Region: DUF482; pfam04339 291331005391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331005392 NAD(P) binding site [chemical binding]; other site 291331005393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331005394 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 291331005395 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 291331005396 rRNA binding site [nucleotide binding]; other site 291331005397 predicted 30S ribosome binding site; other site 291331005398 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 291331005399 Clp amino terminal domain; Region: Clp_N; pfam02861 291331005400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331005401 Walker A motif; other site 291331005402 ATP binding site [chemical binding]; other site 291331005403 Walker B motif; other site 291331005404 arginine finger; other site 291331005405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331005406 Walker A motif; other site 291331005407 ATP binding site [chemical binding]; other site 291331005408 Walker B motif; other site 291331005409 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 291331005410 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 291331005411 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_2; cd03675 291331005412 nudix motif; other site 291331005413 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 291331005414 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 291331005415 Protein of unknown function (DUF489); Region: DUF489; cl01097 291331005416 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 291331005417 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 291331005418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 291331005419 PAS fold; Region: PAS_3; pfam08447 291331005420 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 291331005421 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331005422 metal binding site [ion binding]; metal-binding site 291331005423 active site 291331005424 I-site; other site 291331005425 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 291331005426 PAS fold; Region: PAS_4; pfam08448 291331005427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 291331005428 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 291331005429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 291331005430 putative active site [active] 291331005431 heme pocket [chemical binding]; other site 291331005432 Histidine kinase; Region: HisKA_3; pfam07730 291331005433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331005434 ATP binding site [chemical binding]; other site 291331005435 Mg2+ binding site [ion binding]; other site 291331005436 G-X-G motif; other site 291331005437 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331005438 metal binding site [ion binding]; metal-binding site 291331005439 active site 291331005440 I-site; other site 291331005441 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 291331005442 Response regulator receiver domain; Region: Response_reg; pfam00072 291331005443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331005444 active site 291331005445 phosphorylation site [posttranslational modification] 291331005446 intermolecular recognition site; other site 291331005447 dimerization interface [polypeptide binding]; other site 291331005448 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 291331005449 Mediator complex subunit 30; Region: Med30; pfam11315 291331005450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331005451 ATP binding site [chemical binding]; other site 291331005452 Mg2+ binding site [ion binding]; other site 291331005453 G-X-G motif; other site 291331005454 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 291331005455 SAF domain; Region: SAF; cl00555 291331005456 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 291331005457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331005458 active site 291331005459 phosphorylation site [posttranslational modification] 291331005460 intermolecular recognition site; other site 291331005461 dimerization interface [polypeptide binding]; other site 291331005462 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 291331005463 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12620 291331005464 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12629 291331005465 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 291331005466 Flagellar hook capping protein; Region: FlgD; cl04347 291331005467 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 291331005468 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 291331005469 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 291331005470 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 291331005471 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 291331005472 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 291331005473 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 291331005474 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 291331005475 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 291331005476 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 291331005477 Flagellar L-ring protein; Region: FlgH; cl00905 291331005478 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 291331005479 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 291331005480 flagellar rod assembly protein/muramidase FlgJ; Reviewed; Region: flgJ; PRK12711 291331005481 Rod binding protein; Region: Rod-binding; cl01626 291331005482 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 291331005483 flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12714 291331005484 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 291331005485 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 291331005486 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 291331005487 flagellin; Reviewed; Region: PRK08869 291331005488 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 291331005489 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 291331005490 flagellar capping protein; Reviewed; Region: fliD; PRK08032 291331005491 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 291331005492 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 291331005493 Flagellar protein FliS; Region: FliS; cl00654 291331005494 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 291331005495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331005496 active site 291331005497 phosphorylation site [posttranslational modification] 291331005498 intermolecular recognition site; other site 291331005499 dimerization interface [polypeptide binding]; other site 291331005500 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 291331005501 DNA binding residues [nucleotide binding] 291331005502 dimerization interface [polypeptide binding]; other site 291331005503 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 291331005504 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 291331005505 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 291331005506 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 291331005507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331005508 active site 291331005509 phosphorylation site [posttranslational modification] 291331005510 intermolecular recognition site; other site 291331005511 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 291331005512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 291331005513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331005514 Walker A motif; other site 291331005515 ATP binding site [chemical binding]; other site 291331005516 Walker B motif; other site 291331005517 arginine finger; other site 291331005518 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 291331005519 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 291331005520 inhibitor-cofactor binding pocket; inhibition site 291331005521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331005522 catalytic residue [active] 291331005523 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 291331005524 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 291331005525 dimer interface [polypeptide binding]; other site 291331005526 active site 291331005527 CoA binding pocket [chemical binding]; other site 291331005528 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 291331005529 classical (c) SDRs; Region: SDR_c; cd05233 291331005530 NAD(P) binding site [chemical binding]; other site 291331005531 active site 291331005532 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 291331005533 classical (c) SDRs; Region: SDR_c; cd05233 291331005534 NAD(P) binding site [chemical binding]; other site 291331005535 active site 291331005536 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 291331005537 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 291331005538 [2Fe-2S] cluster binding site [ion binding]; other site 291331005539 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 291331005540 alpha subunit interface [polypeptide binding]; other site 291331005541 active site 291331005542 substrate binding site [chemical binding]; other site 291331005543 Fe binding site [ion binding]; other site 291331005544 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 291331005545 putative trimer interface [polypeptide binding]; other site 291331005546 putative CoA binding site [chemical binding]; other site 291331005547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331005548 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 291331005549 active site 291331005550 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 291331005551 active site 291331005552 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 291331005553 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 291331005554 flagellar MS-ring protein; Reviewed; Region: fliF; PRK12800 291331005555 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 291331005556 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 291331005557 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 291331005558 FliG C-terminal domain; Region: FliG_C; pfam01706 291331005559 flagellar assembly protein H; Validated; Region: fliH; PRK06669 291331005560 Flagellar assembly protein FliH; Region: FliH; pfam02108 291331005561 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 291331005562 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331005563 Walker A motif; other site 291331005564 ATP binding site [chemical binding]; other site 291331005565 Walker B motif; other site 291331005566 Flagellar FliJ protein; Region: FliJ; cl09161 291331005567 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 291331005568 Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669 291331005569 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 291331005570 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 291331005571 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 291331005572 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 291331005573 FliP family; Region: FliP; cl00593 291331005574 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 291331005575 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 291331005576 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 291331005577 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 291331005578 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 291331005579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331005580 metal binding site [ion binding]; metal-binding site 291331005581 active site 291331005582 I-site; other site 291331005583 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 291331005584 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 291331005585 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 291331005586 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331005587 metal binding site [ion binding]; metal-binding site 291331005588 active site 291331005589 I-site; other site 291331005590 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 291331005591 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 291331005592 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331005593 metal binding site [ion binding]; metal-binding site 291331005594 active site 291331005595 I-site; other site 291331005596 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 291331005597 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 291331005598 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 291331005599 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 291331005600 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 291331005601 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12727 291331005602 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 291331005603 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 291331005604 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 291331005605 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 291331005606 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 291331005607 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 291331005608 DNA binding residues [nucleotide binding] 291331005609 Response regulator receiver domain; Region: Response_reg; pfam00072 291331005610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331005611 active site 291331005612 phosphorylation site [posttranslational modification] 291331005613 intermolecular recognition site; other site 291331005614 dimerization interface [polypeptide binding]; other site 291331005615 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 291331005616 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 291331005617 putative binding surface; other site 291331005618 active site 291331005619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331005620 ATP binding site [chemical binding]; other site 291331005621 Mg2+ binding site [ion binding]; other site 291331005622 G-X-G motif; other site 291331005623 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 291331005624 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331005625 Integrase core domain; Region: rve; cl01316 291331005626 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331005627 Transposase domain (DUF772); Region: DUF772; cl12084 291331005628 RHS Repeat; Region: RHS_repeat; cl11982 291331005629 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 291331005630 RHS Repeat; Region: RHS_repeat; cl11982 291331005631 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 291331005632 NlpC/P60 family; Region: NLPC_P60; cl11438 291331005634 Transposase domain (DUF772); Region: DUF772; cl12084 291331005635 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331005636 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 291331005637 Protein export membrane protein; Region: SecD_SecF; cl14618 291331005638 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 291331005639 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 291331005640 Cytochrome c; Region: Cytochrom_C; cl11414 291331005641 Cytochrome c; Region: Cytochrom_C; cl11414 291331005642 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331005643 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331005644 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331005646 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 291331005647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331005648 Walker A/P-loop; other site 291331005649 ATP binding site [chemical binding]; other site 291331005650 Q-loop/lid; other site 291331005651 ABC transporter signature motif; other site 291331005652 Walker B; other site 291331005653 D-loop; other site 291331005654 H-loop/switch region; other site 291331005655 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 291331005656 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 291331005657 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331005658 Walker A/P-loop; other site 291331005659 ATP binding site [chemical binding]; other site 291331005660 Q-loop/lid; other site 291331005661 ABC transporter signature motif; other site 291331005662 Walker B; other site 291331005663 D-loop; other site 291331005664 H-loop/switch region; other site 291331005665 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331005666 Integrase core domain; Region: rve; cl01316 291331005668 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 291331005669 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 291331005670 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 291331005671 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 291331005672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331005673 putative substrate translocation pore; other site 291331005674 Predicted acyl esterases [General function prediction only]; Region: COG2936 291331005675 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 291331005676 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 291331005677 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 291331005678 putative catalytic cysteine [active] 291331005679 gamma-glutamyl kinase; Provisional; Region: PRK05429 291331005680 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 291331005681 nucleotide binding site [chemical binding]; other site 291331005682 substrate binding site [chemical binding]; other site 291331005683 PUA domain; Region: PUA; cl00607 291331005684 YCII-related domain; Region: YCII; cl00999 291331005685 Cupin domain; Region: Cupin_2; cl09118 291331005686 argininosuccinate lyase; Provisional; Region: PRK00855 291331005687 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 291331005688 active sites [active] 291331005689 tetramer interface [polypeptide binding]; other site 291331005690 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 291331005691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331005692 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 291331005693 acetylglutamate kinase; Provisional; Region: PRK04531 291331005694 AAK_NAGK-fArgBP: N-Acetyl-L-glutamate kinase (NAGK) of the fungal arginine-biosynthetic pathway (fArgBP). The nuclear-encoded, mitochondrial polyprotein precursor with an N-terminal NAGK (ArgB) domain (this CD), a central DUF619 domain, and a C-...; Region: AAK_NAGK-fArgBP; cd04252 291331005695 putative nucleotide binding site [chemical binding]; other site 291331005696 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 291331005697 DUF619 domain of various N-acetylglutamate Synthases of the fungal arginine-biosynthetic pathway and urea cycle found in humans and fish; Region: DUF619-NAGS; cd04264 291331005698 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 291331005699 M28, and M42; Region: Zinc_peptidase_like; cl14876 291331005700 metal binding site [ion binding]; metal-binding site 291331005701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331005702 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 291331005703 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 291331005704 ANP binding site [chemical binding]; other site 291331005705 Substrate Binding Site II [chemical binding]; other site 291331005706 Substrate Binding Site I [chemical binding]; other site 291331005707 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 291331005708 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 291331005709 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 291331005710 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 291331005711 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291331005712 active site 291331005713 HIGH motif; other site 291331005714 nucleotide binding site [chemical binding]; other site 291331005715 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 291331005716 KMSKS motif; other site 291331005717 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 291331005718 tRNA binding surface [nucleotide binding]; other site 291331005719 anticodon binding site; other site 291331005720 Fe-S metabolism associated domain; Region: SufE; cl00951 291331005721 H+ Antiporter protein; Region: 2A0121; TIGR00900 291331005722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331005723 putative substrate translocation pore; other site 291331005724 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 291331005725 active site triad [active] 291331005726 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 291331005727 dihydroorotase; Reviewed; Region: PRK09236 291331005728 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 291331005729 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 291331005730 active site 291331005731 Peptidase family M23; Region: Peptidase_M23; pfam01551 291331005732 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 291331005733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331005734 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 291331005735 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331005736 Transposase domain (DUF772); Region: DUF772; cl12084 291331005737 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331005738 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331005739 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331005740 Pectinesterase; Region: Pectinesterase; cl01911 291331005741 Pectin methylesterase [Carbohydrate transport and metabolism]; Region: PemB; COG4677 291331005742 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 291331005743 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 291331005744 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 291331005745 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 291331005746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 291331005747 motif II; other site 291331005748 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 291331005749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331005750 S-adenosylmethionine binding site [chemical binding]; other site 291331005751 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 291331005752 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 291331005753 active site 291331005754 putative substrate binding pocket [chemical binding]; other site 291331005755 elongation factor P; Validated; Region: PRK00529 291331005756 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 291331005757 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 291331005758 RNA binding site [nucleotide binding]; other site 291331005759 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 291331005760 RNA binding site [nucleotide binding]; other site 291331005762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331005763 metal binding site [ion binding]; metal-binding site 291331005764 active site 291331005765 I-site; other site 291331005766 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 291331005767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331005768 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 291331005769 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 291331005770 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 291331005771 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 291331005772 active site 291331005773 dimerization interface [polypeptide binding]; other site 291331005774 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 291331005775 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 291331005776 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 291331005777 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a...; Region: RNase_Sa; cd00607 291331005778 active site 291331005779 barstar interaction site; other site 291331005780 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 291331005781 putative RNAase interaction site [polypeptide binding]; other site 291331005782 ABC transporter ATPase component; Reviewed; Region: PRK11147 291331005783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331005784 Walker A/P-loop; other site 291331005785 ATP binding site [chemical binding]; other site 291331005786 Q-loop/lid; other site 291331005787 ABC transporter signature motif; other site 291331005788 Walker B; other site 291331005789 D-loop; other site 291331005790 H-loop/switch region; other site 291331005791 ABC transporter; Region: ABC_tran_2; pfam12848 291331005792 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 291331005793 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 291331005794 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 291331005795 ATP binding site [chemical binding]; other site 291331005796 Mg++ binding site [ion binding]; other site 291331005797 motif III; other site 291331005798 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331005799 nucleotide binding region [chemical binding]; other site 291331005800 ATP-binding site [chemical binding]; other site 291331005801 DbpA RNA binding domain; Region: DbpA; pfam03880 291331005802 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 291331005803 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 291331005804 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 291331005805 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 291331005806 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331005807 substrate binding pocket [chemical binding]; other site 291331005808 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 291331005809 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 291331005810 putative C-terminal domain interface [polypeptide binding]; other site 291331005811 putative GSH binding site (G-site) [chemical binding]; other site 291331005812 putative dimer interface [polypeptide binding]; other site 291331005813 GST_C family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_C_GTT1_like; cd03189 291331005814 putative N-terminal domain interface [polypeptide binding]; other site 291331005815 putative dimer interface [polypeptide binding]; other site 291331005816 putative substrate binding pocket (H-site) [chemical binding]; other site 291331005817 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 291331005818 DNA-binding site [nucleotide binding]; DNA binding site 291331005819 RNA-binding motif; other site 291331005820 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 291331005821 YaeQ protein; Region: YaeQ; cl01913 291331005822 Predicted flavoproteins [General function prediction only]; Region: COG2081 291331005823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331005824 Response regulator receiver domain; Region: Response_reg; pfam00072 291331005825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331005826 active site 291331005827 phosphorylation site [posttranslational modification] 291331005828 intermolecular recognition site; other site 291331005829 dimerization interface [polypeptide binding]; other site 291331005830 PAS domain S-box; Region: sensory_box; TIGR00229 291331005831 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331005832 metal binding site [ion binding]; metal-binding site 291331005833 active site 291331005834 I-site; other site 291331005835 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 291331005836 Peptidase family M48; Region: Peptidase_M48; cl12018 291331005837 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291331005838 active site 291331005839 HIGH motif; other site 291331005840 nucleotide binding site [chemical binding]; other site 291331005841 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291331005842 active site 291331005843 KMSKS motif; other site 291331005844 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 291331005845 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 291331005846 NAD(P) binding site [chemical binding]; other site 291331005847 homotetramer interface [polypeptide binding]; other site 291331005848 homodimer interface [polypeptide binding]; other site 291331005849 active site 291331005850 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 291331005851 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 291331005852 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 291331005853 TraB family; Region: TraB; cl12050 291331005854 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 291331005855 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 291331005856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331005857 ATP binding site [chemical binding]; other site 291331005858 Mg2+ binding site [ion binding]; other site 291331005859 G-X-G motif; other site 291331005860 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 291331005861 ATP binding site [chemical binding]; other site 291331005862 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 291331005863 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 291331005864 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 291331005865 active site 291331005866 metal binding site [ion binding]; metal-binding site 291331005867 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 291331005868 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 291331005869 putative carbohydrate kinase; Provisional; Region: PRK10565 291331005870 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 291331005871 putative substrate binding site [chemical binding]; other site 291331005872 putative ATP binding site [chemical binding]; other site 291331005873 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 291331005874 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 291331005875 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 291331005876 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 291331005877 generic binding surface II; other site 291331005878 generic binding surface I; other site 291331005879 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 291331005880 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331005881 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331005882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331005883 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 291331005884 ribonuclease D; Region: rnd; TIGR01388 291331005885 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 291331005886 putative active site [active] 291331005887 catalytic site [active] 291331005888 putative substrate binding site [chemical binding]; other site 291331005889 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 291331005890 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 291331005891 Integrase core domain; Region: rve; cl01316 291331005892 Transposase, Mutator family; Region: Transposase_mut; pfam00872 291331005893 MULE transposase domain; Region: MULE; pfam10551 291331005894 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331005895 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331005896 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331005897 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 291331005898 active site 291331005899 DNA binding site [nucleotide binding] 291331005900 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 291331005901 Stringent starvation protein B; Region: SspB; cl01120 291331005902 stringent starvation protein A; Provisional; Region: sspA; PRK09481 291331005903 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 291331005904 C-terminal domain interface [polypeptide binding]; other site 291331005905 putative GSH binding site (G-site) [chemical binding]; other site 291331005906 dimer interface [polypeptide binding]; other site 291331005907 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_C_SspA; cd03186 291331005908 N-terminal domain interface [polypeptide binding]; other site 291331005909 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 291331005910 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 291331005911 Qi binding site; other site 291331005912 intrachain domain interface; other site 291331005913 interchain domain interface [polypeptide binding]; other site 291331005914 cytochrome b; Provisional; Region: CYTB; MTH00156 291331005915 heme bH binding site [chemical binding]; other site 291331005916 heme bL binding site [chemical binding]; other site 291331005917 Qo binding site; other site 291331005918 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cl00193 291331005919 interchain domain interface [polypeptide binding]; other site 291331005920 intrachain domain interface; other site 291331005921 Qi binding site; other site 291331005922 Qo binding site; other site 291331005923 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 291331005924 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 291331005925 [2Fe-2S] cluster binding site [ion binding]; other site 291331005926 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 291331005927 N-acetyl-D-glucosamine binding site [chemical binding]; other site 291331005928 catalytic residue [active] 291331005929 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331005930 Predicted transcriptional regulator [Transcription]; Region: COG2378 291331005931 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 291331005932 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 291331005933 dimer interface [polypeptide binding]; other site 291331005934 substrate binding pocket (H-site) [chemical binding]; other site 291331005935 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 291331005936 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 291331005937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 291331005938 FeS/SAM binding site; other site 291331005939 TRAM domain; Region: TRAM; cl01282 291331005940 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 291331005941 PhoH-like protein; Region: PhoH; cl12134 291331005942 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 291331005943 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 291331005944 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 291331005945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 291331005946 Transporter associated domain; Region: CorC_HlyC; pfam03471 291331005947 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 291331005948 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 291331005949 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 291331005950 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 291331005951 NAD(P) binding site [chemical binding]; other site 291331005952 catalytic residues [active] 291331005953 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 291331005954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 291331005955 dimer interface [polypeptide binding]; other site 291331005956 conserved gate region; other site 291331005957 putative PBP binding loops; other site 291331005958 ABC-ATPase subunit interface; other site 291331005959 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 291331005960 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331005961 Walker A/P-loop; other site 291331005962 ATP binding site [chemical binding]; other site 291331005963 Q-loop/lid; other site 291331005964 ABC transporter signature motif; other site 291331005965 Walker B; other site 291331005966 D-loop; other site 291331005967 H-loop/switch region; other site 291331005968 TOBE domain; Region: TOBE_2; cl01440 291331005969 NodT family; Region: outer_NodT; TIGR01845 291331005970 Outer membrane efflux protein; Region: OEP; pfam02321 291331005971 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 291331005972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331005973 putative substrate translocation pore; other site 291331005974 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 291331005975 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331005976 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 291331005977 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 291331005978 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 291331005979 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 291331005980 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 291331005981 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 291331005982 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 291331005983 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 291331005984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331005985 Response regulator receiver domain; Region: Response_reg; pfam00072 291331005986 active site 291331005987 phosphorylation site [posttranslational modification] 291331005988 intermolecular recognition site; other site 291331005989 dimerization interface [polypeptide binding]; other site 291331005990 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331005991 metal binding site [ion binding]; metal-binding site 291331005992 active site 291331005993 I-site; other site 291331005994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331005995 metabolite-proton symporter; Region: 2A0106; TIGR00883 291331005996 putative substrate translocation pore; other site 291331005997 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 291331005998 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 291331005999 putative molybdopterin cofactor binding site [chemical binding]; other site 291331006000 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 291331006001 putative molybdopterin cofactor binding site; other site 291331006002 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 291331006003 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 291331006004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331006005 Integrase core domain; Region: rve; cl01316 291331006006 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 291331006007 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 291331006008 inhibitor-cofactor binding pocket; inhibition site 291331006009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331006010 catalytic residue [active] 291331006011 ABC transporter G-25; Provisional; Region: PLN03211 291331006012 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 291331006013 recombination factor protein RarA; Reviewed; Region: PRK13342 291331006014 G1 box; other site 291331006015 GTP/Mg2+ binding site [chemical binding]; other site 291331006016 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 291331006017 Predicted membrane protein [Function unknown]; Region: COG2733 291331006018 CHASE domain; Region: CHASE; cl01369 291331006019 PAS domain S-box; Region: sensory_box; TIGR00229 291331006020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 291331006021 putative active site [active] 291331006022 heme pocket [chemical binding]; other site 291331006023 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 291331006024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 291331006025 putative active site [active] 291331006026 heme pocket [chemical binding]; other site 291331006027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331006028 dimer interface [polypeptide binding]; other site 291331006029 phosphorylation site [posttranslational modification] 291331006030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331006031 ATP binding site [chemical binding]; other site 291331006032 Mg2+ binding site [ion binding]; other site 291331006033 G-X-G motif; other site 291331006034 Response regulator receiver domain; Region: Response_reg; pfam00072 291331006035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331006036 active site 291331006037 phosphorylation site [posttranslational modification] 291331006038 intermolecular recognition site; other site 291331006039 dimerization interface [polypeptide binding]; other site 291331006040 Response regulator receiver domain; Region: Response_reg; pfam00072 291331006041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331006042 active site 291331006043 phosphorylation site [posttranslational modification] 291331006044 intermolecular recognition site; other site 291331006045 dimerization interface [polypeptide binding]; other site 291331006046 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 291331006047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331006048 active site 291331006049 phosphorylation site [posttranslational modification] 291331006050 intermolecular recognition site; other site 291331006051 dimerization interface [polypeptide binding]; other site 291331006052 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 291331006053 Zn2+ binding site [ion binding]; other site 291331006054 Mg2+ binding site [ion binding]; other site 291331006055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331006056 putative transporter; Provisional; Region: PRK10504 291331006057 putative substrate translocation pore; other site 291331006058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331006059 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331006060 Integrase core domain; Region: rve; cl01316 291331006061 Transposase domain (DUF772); Region: DUF772; cl12084 291331006062 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331006063 Glutamate dehydrogenase N terminal; Region: GDH_N; pfam12466 291331006064 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 291331006065 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 291331006066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 291331006067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 291331006068 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 291331006069 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 291331006070 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 291331006071 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331006072 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331006073 Transcriptional regulators [Transcription]; Region: PurR; COG1609 291331006074 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 291331006075 DNA binding site [nucleotide binding] 291331006076 domain linker motif; other site 291331006077 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 291331006078 putative dimerization interface [polypeptide binding]; other site 291331006079 putative ligand binding site [chemical binding]; other site 291331006080 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 291331006081 active site 291331006082 phosphorylation site [posttranslational modification] 291331006083 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 291331006084 dimerization domain swap beta strand [polypeptide binding]; other site 291331006085 regulatory protein interface [polypeptide binding]; other site 291331006086 active site 291331006087 regulatory phosphorylation site [posttranslational modification]; other site 291331006088 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 291331006089 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 291331006090 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 291331006091 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 291331006092 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 291331006093 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 291331006094 putative substrate binding site [chemical binding]; other site 291331006095 putative ATP binding site [chemical binding]; other site 291331006096 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 291331006097 P-loop; other site 291331006098 active site 291331006099 phosphorylation site [posttranslational modification] 291331006100 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 291331006101 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 291331006102 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 291331006103 Transposase domain (DUF772); Region: DUF772; cl12084 291331006104 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331006105 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331006106 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 291331006107 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331006109 HSP20-like domain of unknown function (DUF1813); Region: DUF1813; cl07446 291331006110 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331006111 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331006112 Transposase domain (DUF772); Region: DUF772; cl12084 291331006113 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331006114 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331006115 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331006116 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331006117 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 291331006118 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331006119 ligand-binding site [chemical binding]; other site 291331006120 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 291331006121 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 291331006122 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 291331006123 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 291331006124 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 291331006125 flagellar motor protein MotA; Validated; Region: PRK08124 291331006126 flagellar motor protein MotD; Reviewed; Region: PRK09038 291331006127 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 291331006128 ligand binding site [chemical binding]; other site 291331006129 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 291331006130 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 291331006131 P-loop; other site 291331006132 Magnesium ion binding site [ion binding]; other site 291331006133 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 291331006134 Magnesium ion binding site [ion binding]; other site 291331006135 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 291331006136 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 291331006137 anti sigma factor interaction site; other site 291331006138 regulatory phosphorylation site [posttranslational modification]; other site 291331006139 Response regulator receiver domain; Region: Response_reg; pfam00072 291331006140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331006141 active site 291331006142 phosphorylation site [posttranslational modification] 291331006143 intermolecular recognition site; other site 291331006144 dimerization interface [polypeptide binding]; other site 291331006145 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 291331006146 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 291331006147 putative binding surface; other site 291331006148 active site 291331006149 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 291331006150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331006151 ATP binding site [chemical binding]; other site 291331006152 Mg2+ binding site [ion binding]; other site 291331006153 G-X-G motif; other site 291331006154 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 291331006155 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331006156 Integrase core domain; Region: rve; cl01316 291331006157 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 291331006158 PAS fold; Region: PAS; pfam00989 291331006159 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 291331006160 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 291331006161 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331006162 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331006163 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 291331006164 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 291331006165 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 291331006166 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 291331006167 CHASE3 domain; Region: CHASE3; cl05000 291331006168 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 291331006169 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 291331006170 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 291331006171 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 291331006172 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 291331006173 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 291331006174 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 291331006175 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 291331006176 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 291331006177 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 291331006178 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 291331006179 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 291331006180 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 291331006181 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 291331006182 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 291331006183 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 291331006184 Flagellar regulator YcgR; Region: YcgR; pfam07317 291331006185 PilZ domain; Region: PilZ; cl01260 291331006186 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 291331006187 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331006188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331006189 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331006190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331006192 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 291331006193 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 291331006194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331006195 CheD chemotactic sensory transduction; Region: CheD; cl00810 291331006196 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 291331006197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331006198 active site 291331006199 phosphorylation site [posttranslational modification] 291331006200 intermolecular recognition site; other site 291331006201 dimerization interface [polypeptide binding]; other site 291331006202 CheB methylesterase; Region: CheB_methylest; pfam01339 291331006203 PAS domain S-box; Region: sensory_box; TIGR00229 291331006204 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 291331006205 putative active site [active] 291331006206 heme pocket [chemical binding]; other site 291331006207 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 291331006208 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331006209 metal binding site [ion binding]; metal-binding site 291331006210 active site 291331006211 I-site; other site 291331006212 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 291331006213 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 291331006214 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331006215 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 291331006216 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change...; Region: AcnB_Swivel; cd01576 291331006217 substrate binding site [chemical binding]; other site 291331006218 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 291331006219 substrate binding site [chemical binding]; other site 291331006220 ligand binding site [chemical binding]; other site 291331006221 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 291331006222 putative active site [active] 291331006223 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 291331006224 aconitate hydratase; Validated; Region: PRK09277 291331006225 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 291331006226 substrate binding site [chemical binding]; other site 291331006227 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 291331006228 ligand binding site [chemical binding]; other site 291331006229 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 291331006230 substrate binding site [chemical binding]; other site 291331006231 putative long-chain fatty acyl CoA ligase; Provisional; Region: PRK08751 291331006232 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 291331006233 enoyl-CoA hydratase; Validated; Region: PRK08788 291331006234 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 291331006235 substrate binding site [chemical binding]; other site 291331006236 oxyanion hole (OAH) forming residues; other site 291331006237 trimer interface [polypeptide binding]; other site 291331006238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331006239 dimer interface [polypeptide binding]; other site 291331006240 phosphorylation site [posttranslational modification] 291331006241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331006242 ATP binding site [chemical binding]; other site 291331006243 Mg2+ binding site [ion binding]; other site 291331006244 G-X-G motif; other site 291331006245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331006246 Response regulator receiver domain; Region: Response_reg; pfam00072 291331006247 active site 291331006248 phosphorylation site [posttranslational modification] 291331006249 intermolecular recognition site; other site 291331006250 dimerization interface [polypeptide binding]; other site 291331006251 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 291331006252 putative binding surface; other site 291331006253 active site 291331006254 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 291331006255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331006256 active site 291331006257 phosphorylation site [posttranslational modification] 291331006258 intermolecular recognition site; other site 291331006259 dimerization interface [polypeptide binding]; other site 291331006260 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 291331006261 Zn2+ binding site [ion binding]; other site 291331006262 Mg2+ binding site [ion binding]; other site 291331006263 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 291331006264 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 291331006265 dimer interface [polypeptide binding]; other site 291331006266 putative anticodon binding site; other site 291331006267 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 291331006268 motif 1; other site 291331006269 active site 291331006270 motif 2; other site 291331006271 motif 3; other site 291331006272 peptide chain release factor 2; Provisional; Region: PRK08787 291331006273 RF-1 domain; Region: RF-1; cl02875 291331006274 RF-1 domain; Region: RF-1; cl02875 291331006275 LytTr DNA-binding domain; Region: LytTR; cl04498 291331006276 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 291331006277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331006278 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331006279 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331006280 Integrase core domain; Region: rve; cl01316 291331006281 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331006282 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331006283 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 291331006284 DHH family; Region: DHH; pfam01368 291331006285 DHHA1 domain; Region: DHHA1; pfam02272 291331006286 Sulfatase; Region: Sulfatase; cl10460 291331006287 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 291331006288 domain; Region: GreA_GreB_N; pfam03449 291331006289 C-term; Region: GreA_GreB; pfam01272 291331006290 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 291331006291 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 291331006292 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331006293 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 291331006294 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 291331006295 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331006296 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 291331006297 IMP binding site; other site 291331006298 dimer interface [polypeptide binding]; other site 291331006299 interdomain contacts; other site 291331006300 partial ornithine binding site; other site 291331006301 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 291331006302 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 291331006303 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 291331006304 catalytic site [active] 291331006305 subunit interface [polypeptide binding]; other site 291331006307 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331006308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 291331006309 MOSC domain; Region: MOSC; pfam03473 291331006310 3-alpha domain; Region: 3-alpha; pfam03475 291331006311 aspartate aminotransferase; Provisional; Region: PRK06836 291331006312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 291331006313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331006314 homodimer interface [polypeptide binding]; other site 291331006315 catalytic residue [active] 291331006316 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 291331006317 G1 box; other site 291331006318 GTP/Mg2+ binding site [chemical binding]; other site 291331006319 Switch I region; other site 291331006320 G2 box; other site 291331006321 G3 box; other site 291331006322 Switch II region; other site 291331006323 G4 box; other site 291331006324 G5 box; other site 291331006325 Nucleoside recognition; Region: Gate; cl00486 291331006326 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 291331006327 Nucleoside recognition; Region: Gate; cl00486 291331006328 FeoA domain; Region: FeoA; cl00838 291331006329 enoyl-CoA hydratase; Provisional; Region: PRK05995 291331006330 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 291331006331 substrate binding site [chemical binding]; other site 291331006332 oxyanion hole (OAH) forming residues; other site 291331006333 trimer interface [polypeptide binding]; other site 291331006334 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 291331006335 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 291331006336 active site 291331006337 catalytic residues [active] 291331006338 metal binding site [ion binding]; metal-binding site 291331006339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331006340 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 291331006341 NAD(P) binding site [chemical binding]; other site 291331006342 active site 291331006343 elongation factor P; Provisional; Region: PRK04542 291331006344 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 291331006345 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 291331006346 RNA binding site [nucleotide binding]; other site 291331006347 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 291331006348 RNA binding site [nucleotide binding]; other site 291331006349 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 291331006350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331006351 putative substrate translocation pore; other site 291331006352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331006353 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 291331006354 xylose isomerase; Region: PLN02923 291331006355 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 291331006356 D-xylulose kinase; Region: XylB; TIGR01312 291331006357 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 291331006358 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 291331006359 PA14 domain; Region: PA14; cl08459 291331006360 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 291331006361 putative active site [active] 291331006362 putative catalytic site [active] 291331006363 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 291331006364 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331006365 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 291331006366 putative dimerization interface [polypeptide binding]; other site 291331006367 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 291331006368 active site 291331006369 intersubunit interface [polypeptide binding]; other site 291331006370 catalytic residue [active] 291331006371 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 291331006372 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 291331006373 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 291331006374 Ferredoxin [Energy production and conversion]; Region: COG1146 291331006375 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 291331006376 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 291331006377 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 291331006378 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 291331006379 dimer interface [polypeptide binding]; other site 291331006380 active site 291331006381 catalytic residue [active] 291331006382 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 291331006383 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 291331006384 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 291331006385 Protein of unknown function (DUF1260); Region: DUF1260; cl01170 291331006386 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 291331006387 catalytic triad [active] 291331006388 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 291331006389 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 291331006390 putative active site [active] 291331006391 PhoH-like protein; Region: PhoH; cl12134 291331006392 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 291331006393 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 291331006394 dimer interface [polypeptide binding]; other site 291331006395 substrate binding site [chemical binding]; other site 291331006396 ATP binding site [chemical binding]; other site 291331006397 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 291331006398 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 291331006399 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 291331006400 active site residue [active] 291331006401 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 291331006402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331006403 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331006404 dimerization interface [polypeptide binding]; other site 291331006405 Pirin-related protein [General function prediction only]; Region: COG1741 291331006406 Cupin domain; Region: Cupin_2; cl09118 291331006407 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 291331006408 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 291331006409 catalytic residue [active] 291331006410 IPP transferase; Region: IPPT; cl00403 291331006411 Global regulator protein family; Region: CsrA; cl00670 291331006412 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 291331006413 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 291331006414 motif 1; other site 291331006415 active site 291331006416 motif 2; other site 291331006417 motif 3; other site 291331006418 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 291331006419 DHHA1 domain; Region: DHHA1; pfam02272 291331006420 RecX family; Region: RecX; cl00936 291331006421 recombinase A; Provisional; Region: recA; PRK09354 291331006422 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 291331006423 hexamer interface [polypeptide binding]; other site 291331006424 Walker A motif; other site 291331006425 ATP binding site [chemical binding]; other site 291331006426 Walker B motif; other site 291331006427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331006428 LexA repressor; Validated; Region: PRK00215 291331006429 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 291331006430 Catalytic site [active] 291331006431 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 291331006432 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 291331006433 Competence-damaged protein; Region: CinA; cl00666 291331006434 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 291331006435 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 291331006436 G1 box; other site 291331006437 GTP/Mg2+ binding site [chemical binding]; other site 291331006438 Switch I region; other site 291331006439 G2 box; other site 291331006440 G3 box; other site 291331006441 Switch II region; other site 291331006442 G4 box; other site 291331006443 G5 box; other site 291331006444 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 291331006445 Sm1 motif; other site 291331006446 intra - hexamer interaction site; other site 291331006447 inter - hexamer interaction site [polypeptide binding]; other site 291331006448 nucleotide binding pocket [chemical binding]; other site 291331006449 Sm2 motif; other site 291331006450 IPP transferase; Region: IPPT; cl00403 291331006451 FtsH Extracellular; Region: FtsH_ext; pfam06480 291331006452 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 291331006453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331006454 Walker A motif; other site 291331006455 ATP binding site [chemical binding]; other site 291331006456 Walker B motif; other site 291331006457 arginine finger; other site 291331006458 Peptidase family M41; Region: Peptidase_M41; pfam01434 291331006459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331006460 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 291331006461 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome...; Region: Xcc1710_like; cd05560 291331006462 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 291331006463 putative peptidoglycan binding site; other site 291331006464 Peptidase family M23; Region: Peptidase_M23; pfam01551 291331006465 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 291331006466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331006467 Survival protein SurE; Region: SurE; cl00448 291331006468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 291331006469 Smr domain; Region: Smr; cl02619 291331006470 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 291331006471 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 291331006472 Permutation of conserved domain; other site 291331006473 active site 291331006474 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 291331006475 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 291331006476 homotrimer interaction site [polypeptide binding]; other site 291331006477 zinc binding site [ion binding]; other site 291331006478 CDP-binding sites; other site 291331006479 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 291331006480 substrate binding site [chemical binding]; other site 291331006481 dimer interface [polypeptide binding]; other site 291331006482 Septum formation initiator; Region: DivIC; cl11433 291331006483 enolase; Provisional; Region: eno; PRK00077 291331006484 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 291331006485 dimer interface [polypeptide binding]; other site 291331006486 metal binding site [ion binding]; metal-binding site 291331006487 substrate binding pocket [chemical binding]; other site 291331006488 NeuB family; Region: NeuB; cl00496 291331006489 CTP synthetase; Validated; Region: pyrG; PRK05380 291331006490 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 291331006491 Catalytic site [active] 291331006492 Active site [active] 291331006493 UTP binding site [chemical binding]; other site 291331006494 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 291331006495 active site 291331006496 putative oxyanion hole; other site 291331006497 catalytic triad [active] 291331006498 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 291331006499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 291331006500 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 291331006501 anchoring element; other site 291331006502 dimer interface [polypeptide binding]; other site 291331006503 ATP binding site [chemical binding]; other site 291331006504 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 291331006505 active site 291331006506 metal binding site [ion binding]; metal-binding site 291331006507 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 291331006508 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331006509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331006510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331006511 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 291331006512 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 291331006513 putative active site [active] 291331006514 Phosphate transporter family; Region: PHO4; cl00396 291331006515 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 291331006516 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 291331006517 Domain of unknown function DUF21; Region: DUF21; pfam01595 291331006518 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 291331006519 Transporter associated domain; Region: CorC_HlyC; pfam03471 291331006520 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 291331006521 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 291331006522 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 291331006523 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 291331006524 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 291331006525 benzoate transport; Region: 2A0115; TIGR00895 291331006526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 291331006527 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 291331006528 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331006529 Walker A/P-loop; other site 291331006530 ATP binding site [chemical binding]; other site 291331006531 Q-loop/lid; other site 291331006532 ABC transporter signature motif; other site 291331006533 Walker B; other site 291331006534 D-loop; other site 291331006535 H-loop/switch region; other site 291331006536 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 291331006537 Hpr binding site; other site 291331006538 active site 291331006539 homohexamer subunit interaction site [polypeptide binding]; other site 291331006540 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 291331006541 B12 binding site [chemical binding]; other site 291331006542 Radical SAM; Region: Elp3; smart00729 291331006543 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 291331006544 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 291331006545 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 291331006546 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 291331006547 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 291331006548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331006549 S-adenosylmethionine binding site [chemical binding]; other site 291331006550 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 291331006551 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 291331006552 active site 291331006553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331006554 S-adenosylmethionine binding site [chemical binding]; other site 291331006555 Chain length determinant protein; Region: Wzz; cl01623 291331006556 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 291331006557 active site 291331006558 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 291331006559 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 291331006560 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 291331006561 inhibitor-cofactor binding pocket; inhibition site 291331006562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331006563 catalytic residue [active] 291331006564 FemAB family; Region: FemAB; cl11444 291331006565 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 291331006566 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 291331006567 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 291331006568 putative trimer interface [polypeptide binding]; other site 291331006569 putative CoA binding site [chemical binding]; other site 291331006570 Cupin domain; Region: Cupin_2; cl09118 291331006571 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 291331006572 Cytochrome c; Region: Cytochrom_C; cl11414 291331006573 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 291331006574 RNA polymerase sigma factor; Provisional; Region: PRK12515 291331006575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 291331006576 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 291331006577 DNA binding residues [nucleotide binding] 291331006578 Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492 291331006579 active site 291331006580 catalytic triad [active] 291331006581 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 291331006582 CcmE; Region: CcmE; cl00994 291331006583 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 291331006584 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 291331006585 catalytic residues [active] 291331006586 central insert; other site 291331006587 Cytochrome C biogenesis protein; Region: CcmH; cl01179 291331006588 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 291331006589 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331006590 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331006591 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331006592 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331006593 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331006594 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331006595 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331006596 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331006597 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331006598 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331006599 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331006600 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 291331006601 Transposase domain (DUF772); Region: DUF772; cl12084 291331006602 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 291331006603 Protein export membrane protein; Region: SecD_SecF; cl14618 291331006604 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 291331006605 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331006606 Transposase, Mutator family; Region: Transposase_mut; pfam00872 291331006607 MULE transposase domain; Region: MULE; pfam10551 291331006608 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 291331006609 two-component response regulator VirG; Provisional; Region: PRK13856 291331006610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331006611 active site 291331006612 phosphorylation site [posttranslational modification] 291331006613 intermolecular recognition site; other site 291331006614 dimerization interface [polypeptide binding]; other site 291331006615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331006616 DNA binding site [nucleotide binding] 291331006617 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 291331006618 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 291331006619 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331006620 dimer interface [polypeptide binding]; other site 291331006621 phosphorylation site [posttranslational modification] 291331006622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331006623 ATP binding site [chemical binding]; other site 291331006624 Mg2+ binding site [ion binding]; other site 291331006625 G-X-G motif; other site 291331006626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331006627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 291331006628 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 291331006629 dimerization interface [polypeptide binding]; other site 291331006630 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 291331006631 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 291331006632 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 291331006633 Catalytic domain of Protein Kinases; Region: PKc; cd00180 291331006634 active site 291331006635 ATP binding site [chemical binding]; other site 291331006636 substrate binding site [chemical binding]; other site 291331006637 activation loop (A-loop); other site 291331006638 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 291331006639 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 291331006640 Protein phosphatase 2C; Region: PP2C; pfam00481 291331006641 Active site [active] 291331006642 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 291331006643 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 291331006644 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 291331006645 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 291331006646 hypothetical protein; Provisional; Region: PRK07033 291331006647 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 291331006648 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 291331006649 ligand binding site [chemical binding]; other site 291331006651 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 291331006652 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331006653 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 291331006654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331006655 Walker A motif; other site 291331006656 ATP binding site [chemical binding]; other site 291331006657 Walker B motif; other site 291331006658 arginine finger; other site 291331006659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331006660 Walker A motif; other site 291331006661 ATP binding site [chemical binding]; other site 291331006662 Walker B motif; other site 291331006663 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 291331006664 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 291331006665 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 291331006666 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 291331006667 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 291331006668 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 291331006669 ImpE protein; Region: ImpE; pfam07024 291331006670 Protein of unknown function (DUF796); Region: DUF796; cl01226 291331006671 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 291331006672 Protein of unknown function (DUF877); Region: DUF877; pfam05943 291331006673 Protein of unknown function (DUF770); Region: DUF770; cl01402 291331006674 Transposase domain (DUF772); Region: DUF772; cl12084 291331006675 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331006676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331006677 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331006678 putative transposase OrfB; Reviewed; Region: PHA02517 291331006679 Integrase core domain; Region: rve; cl01316 291331006680 Transposase domain (DUF772); Region: DUF772; cl12084 291331006681 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331006682 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 291331006683 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 291331006684 NifU-like domain; Region: NifU; cl00484 291331006685 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 291331006686 aromatic arch; other site 291331006687 DCoH dimer interaction site [polypeptide binding]; other site 291331006688 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 291331006689 DCoH tetramer interaction site [polypeptide binding]; other site 291331006690 substrate binding site [chemical binding]; other site 291331006691 Gram-negative bacterial tonB protein; Region: TonB; cl10048 291331006692 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 291331006693 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 291331006694 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 291331006695 RNA binding surface [nucleotide binding]; other site 291331006696 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 291331006697 active site 291331006698 ribonuclease E; Reviewed; Region: rne; PRK10811 291331006699 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 291331006700 homodimer interface [polypeptide binding]; other site 291331006701 oligonucleotide binding site [chemical binding]; other site 291331006702 response regulator; Provisional; Region: PRK09483 291331006703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331006704 active site 291331006705 phosphorylation site [posttranslational modification] 291331006706 intermolecular recognition site; other site 291331006707 dimerization interface [polypeptide binding]; other site 291331006708 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 291331006709 DNA binding residues [nucleotide binding] 291331006710 dimerization interface [polypeptide binding]; other site 291331006711 rhodanese superfamily protein; Provisional; Region: PRK05320 291331006712 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 291331006713 active site residue [active] 291331006714 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 291331006715 flavoprotein, HI0933 family; Region: TIGR00275 291331006716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331006717 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 291331006718 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 291331006719 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 291331006720 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 291331006721 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 291331006722 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331006723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331006724 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331006725 Transposase domain (DUF772); Region: DUF772; cl12084 291331006726 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331006727 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331006728 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331006729 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331006730 precorrin-2 dehydrogenase; Validated; Region: PRK06719 291331006731 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 291331006732 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 291331006733 geranylgeranyl diphosphate reductase; Provisional; Region: PLN00093 291331006734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331006735 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 291331006736 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 291331006737 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 291331006738 GTP binding site [chemical binding]; other site 291331006739 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 291331006740 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 291331006741 dimer interface [polypeptide binding]; other site 291331006742 putative functional site; other site 291331006743 putative MPT binding site; other site 291331006744 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331006745 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331006746 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331006747 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331006748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331006749 FtsI repressor; Provisional; Region: PRK10883 291331006750 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 291331006751 Transposase, Mutator family; Region: Transposase_mut; pfam00872 291331006752 MULE transposase domain; Region: MULE; pfam10551 291331006753 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331006754 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 291331006755 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331006756 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 291331006757 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 291331006758 substrate binding site [chemical binding]; other site 291331006759 active site 291331006760 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 291331006761 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 291331006762 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 291331006763 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331006764 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331006765 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 291331006766 Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; pfam09286 291331006767 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 291331006768 active site 291331006769 catalytic triad [active] 291331006770 calcium binding site [ion binding]; other site 291331006771 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 291331006772 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331006773 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 291331006774 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 291331006775 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 291331006776 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 291331006777 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 291331006778 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 291331006779 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279 291331006780 active site 291331006781 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 291331006782 dimer interface [polypeptide binding]; other site 291331006783 NADP binding site [chemical binding]; other site 291331006784 catalytic residues [active] 291331006785 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 291331006786 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 291331006787 inhibitor site; inhibition site 291331006788 active site 291331006789 dimer interface [polypeptide binding]; other site 291331006790 catalytic residue [active] 291331006791 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 291331006792 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 291331006793 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 291331006794 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 291331006795 Proline racemase; Region: Pro_racemase; pfam05544 291331006796 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 291331006797 PAS fold; Region: PAS_4; pfam08448 291331006798 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 291331006799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 291331006800 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 291331006801 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 291331006802 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 291331006803 GTP binding site [chemical binding]; other site 291331006804 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 291331006805 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 291331006806 minor groove reading motif; other site 291331006807 helix-hairpin-helix signature motif; other site 291331006808 substrate binding pocket [chemical binding]; other site 291331006809 active site 291331006810 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 291331006811 DNA binding and oxoG recognition site [nucleotide binding] 291331006812 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 291331006813 histidine kinase; Provisional; Region: PRK13557 291331006814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 291331006815 putative active site [active] 291331006816 heme pocket [chemical binding]; other site 291331006817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 291331006818 Transposase domain (DUF772); Region: DUF772; cl12084 291331006819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331006820 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 291331006821 Predicted transcriptional regulator [Transcription]; Region: COG5340 291331006822 FaeA-like protein; Region: FaeA; pfam04703 291331006823 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331006824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331006825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331006826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331006827 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 291331006828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331006829 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331006830 Integrase core domain; Region: rve; cl01316 291331006831 TraB family; Region: TraB; cl12050 291331006832 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 291331006833 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 291331006834 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 291331006835 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 291331006836 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 291331006837 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 291331006838 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 291331006839 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 291331006840 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 291331006841 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 291331006842 Acyltransferase family; Region: Acyl_transf_3; pfam01757 291331006843 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 291331006844 Bacterial sugar transferase; Region: Bac_transf; cl00939 291331006845 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 291331006846 Chain length determinant protein; Region: Wzz; cl01623 291331006847 Chain length determinant protein; Region: Wzz; cl01623 291331006848 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 291331006849 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 291331006850 SLBB domain; Region: SLBB; pfam10531 291331006851 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 291331006852 DNA binding residues [nucleotide binding] 291331006853 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 291331006854 IHF dimer interface [polypeptide binding]; other site 291331006855 IHF - DNA interface [nucleotide binding]; other site 291331006856 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 291331006857 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 291331006858 putative tRNA-binding site [nucleotide binding]; other site 291331006859 B3/4 domain; Region: B3_4; cl11458 291331006860 tRNA synthetase B5 domain; Region: B5; cl08394 291331006861 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 291331006862 dimer interface [polypeptide binding]; other site 291331006863 motif 1; other site 291331006864 motif 3; other site 291331006865 motif 2; other site 291331006866 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 291331006867 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 291331006868 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 291331006869 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 291331006870 dimer interface [polypeptide binding]; other site 291331006871 motif 1; other site 291331006872 active site 291331006873 motif 2; other site 291331006874 motif 3; other site 291331006875 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 291331006876 23S rRNA binding site [nucleotide binding]; other site 291331006877 L21 binding site [polypeptide binding]; other site 291331006878 L13 binding site [polypeptide binding]; other site 291331006879 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 291331006880 translation initiation factor IF-3; Region: infC; TIGR00168 291331006881 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 291331006882 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 291331006883 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 291331006884 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 291331006885 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 291331006886 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 291331006887 active site 291331006888 dimer interface [polypeptide binding]; other site 291331006889 motif 1; other site 291331006890 motif 2; other site 291331006891 motif 3; other site 291331006892 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 291331006893 anticodon binding site; other site 291331006894 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl02583 291331006895 DNA binding site [nucleotide binding] 291331006896 domain linker motif; other site 291331006897 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331006898 Integrase core domain; Region: rve; cl01316 291331006899 excinuclease ABC subunit B; Provisional; Region: PRK05298 291331006900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 291331006901 ATP binding site [chemical binding]; other site 291331006902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331006903 nucleotide binding region [chemical binding]; other site 291331006904 ATP-binding site [chemical binding]; other site 291331006905 Ultra-violet resistance protein B; Region: UvrB; pfam12344 291331006906 UvrB/uvrC motif; Region: UVR; pfam02151 291331006907 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 291331006908 Type II transport protein GspH; Region: GspH; pfam12019 291331006909 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 291331006910 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 291331006911 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331006912 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331006913 Transposase domain (DUF772); Region: DUF772; cl12084 291331006914 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331006915 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 291331006916 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 291331006917 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 291331006918 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 291331006919 Type II transport protein GspH; Region: GspH; pfam12019 291331006920 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 291331006921 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 291331006922 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 291331006923 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331006924 MarC family integral membrane protein; Region: MarC; cl00919 291331006925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331006926 NAD(P) binding site [chemical binding]; other site 291331006927 active site 291331006928 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 291331006929 putative GSH binding site [chemical binding]; other site 291331006930 catalytic residues [active] 291331006931 superoxide dismutase; Provisional; Region: PRK10543 291331006932 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 291331006933 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 291331006934 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 291331006935 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331006936 AIR carboxylase; Region: AIRC; cl00310 291331006937 Trm112p-like protein; Region: Trm112p; cl01066 291331006938 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 291331006939 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 291331006940 dimerization interface [polypeptide binding]; other site 291331006941 active site 291331006942 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 291331006943 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 291331006944 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 291331006945 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 291331006946 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 291331006947 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 291331006948 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 291331006949 putative nucleic acid binding region [nucleotide binding]; other site 291331006950 G-X-X-G motif; other site 291331006951 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 291331006952 RNA binding site [nucleotide binding]; other site 291331006953 domain interface; other site 291331006954 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 291331006955 16S/18S rRNA binding site [nucleotide binding]; other site 291331006956 S13e-L30e interaction site [polypeptide binding]; other site 291331006957 25S rRNA binding site [nucleotide binding]; other site 291331006958 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04642 291331006959 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 291331006960 RNA binding site [nucleotide binding]; other site 291331006961 active site 291331006962 Ribosome-binding factor A; Region: RBFA; cl00542 291331006963 translation initiation factor IF-2; Validated; Region: infB; PRK05306 291331006964 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 291331006965 translation initiation factor IF-2; Region: IF-2; TIGR00487 291331006966 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 291331006967 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 291331006968 G1 box; other site 291331006969 putative GEF interaction site [polypeptide binding]; other site 291331006970 GTP/Mg2+ binding site [chemical binding]; other site 291331006971 Switch I region; other site 291331006972 G2 box; other site 291331006973 G3 box; other site 291331006974 Switch II region; other site 291331006975 G4 box; other site 291331006976 G5 box; other site 291331006977 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 291331006978 Translation-initiation factor 2; Region: IF-2; pfam11987 291331006979 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 291331006980 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 291331006981 NusA N-terminal domain; Region: NusA_N; pfam08529 291331006982 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 291331006983 RNA binding site [nucleotide binding]; other site 291331006984 homodimer interface [polypeptide binding]; other site 291331006985 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 291331006986 G-X-X-G motif; other site 291331006987 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 291331006988 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 291331006989 ribosome maturation protein RimP; Reviewed; Region: PRK00092 291331006990 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 291331006991 Sm1 motif; other site 291331006992 D3 - B interaction site; other site 291331006993 D1 - D2 interaction site; other site 291331006994 Hfq - Hfq interaction site; other site 291331006995 RNA binding pocket [nucleotide binding]; other site 291331006996 Sm2 motif; other site 291331006997 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 291331006998 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 291331006999 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 291331007000 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 291331007001 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 291331007002 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 291331007003 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 291331007004 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 291331007005 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 291331007006 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 291331007007 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 291331007008 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 291331007009 NADH dehydrogenase; Region: NADHdh; cl00469 291331007010 NADH dehydrogenase subunit G; Validated; Region: PRK09129 291331007011 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 291331007012 catalytic loop [active] 291331007013 iron binding site [ion binding]; other site 291331007014 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 291331007015 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 291331007016 molybdopterin cofactor binding site; other site 291331007017 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 291331007018 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 291331007019 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 291331007020 SLBB domain; Region: SLBB; pfam10531 291331007021 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 291331007022 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 291331007023 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 291331007024 putative dimer interface [polypeptide binding]; other site 291331007025 [2Fe-2S] cluster binding site [ion binding]; other site 291331007026 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 291331007027 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 291331007028 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 291331007029 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 291331007030 Preprotein translocase SecG subunit; Region: SecG; cl09123 291331007031 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 291331007032 substrate binding site [chemical binding]; other site 291331007033 dimer interface [polypeptide binding]; other site 291331007034 catalytic triad [active] 291331007035 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 291331007036 classical (c) SDRs; Region: SDR_c; cd05233 291331007037 NAD(P) binding site [chemical binding]; other site 291331007038 active site 291331007039 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 291331007040 apolar tunnel; other site 291331007041 heme binding site [chemical binding]; other site 291331007042 dimerization interface [polypeptide binding]; other site 291331007043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007044 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 291331007045 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331007046 metal binding site [ion binding]; metal-binding site 291331007047 active site 291331007048 I-site; other site 291331007049 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 291331007050 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 291331007051 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 291331007052 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 291331007053 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 291331007054 active site 291331007055 substrate binding site [chemical binding]; other site 291331007056 metal binding site [ion binding]; metal-binding site 291331007057 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 291331007058 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 291331007059 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 291331007060 substrate binding site [chemical binding]; other site 291331007061 active site 291331007062 catalytic residues [active] 291331007063 heterodimer interface [polypeptide binding]; other site 291331007064 tryptophan synthase, beta chain; Region: PLN02618 291331007065 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 291331007066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331007067 catalytic residue [active] 291331007068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331007069 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 291331007070 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331007071 dimerization interface [polypeptide binding]; other site 291331007072 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 291331007073 active site 291331007074 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 291331007075 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 291331007076 dimerization interface 3.5A [polypeptide binding]; other site 291331007077 active site 291331007078 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 291331007079 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 291331007080 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 291331007081 FimV N-terminal domain; Region: FimV_core; TIGR03505 291331007082 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 291331007083 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 291331007084 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 291331007085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331007086 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 291331007087 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 291331007088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331007089 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 291331007090 Tetramer interface [polypeptide binding]; other site 291331007091 Active site [active] 291331007092 FMN-binding site [chemical binding]; other site 291331007093 HemK family putative methylases; Region: hemK_fam; TIGR00536 291331007094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331007095 S-adenosylmethionine binding site [chemical binding]; other site 291331007096 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 291331007097 Cu(I) binding site [ion binding]; other site 291331007098 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 291331007099 N-acetyl-D-glucosamine binding site [chemical binding]; other site 291331007100 catalytic residue [active] 291331007101 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 291331007102 putative peptidoglycan binding site; other site 291331007103 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 291331007104 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331007105 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 291331007106 domain; Region: GreA_GreB_N; pfam03449 291331007107 C-term; Region: GreA_GreB; pfam01272 291331007108 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 291331007109 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 291331007110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 291331007111 FeS/SAM binding site; other site 291331007112 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 291331007113 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 291331007114 trimer interface [polypeptide binding]; other site 291331007115 active site 291331007116 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 291331007117 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 291331007118 Walker A motif; other site 291331007119 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331007120 Integrase core domain; Region: rve; cl01316 291331007121 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 291331007122 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 291331007123 active site 291331007124 Zn binding site [ion binding]; other site 291331007125 Rhomboid family; Region: Rhomboid; cl11446 291331007126 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 291331007127 DNA binding site [nucleotide binding] 291331007128 active site 291331007129 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331007130 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331007132 glutathione reductase; Validated; Region: PRK06116 291331007133 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 291331007134 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 291331007135 Predicted membrane protein [Function unknown]; Region: COG2311 291331007136 Protein of unknown function (DUF418); Region: DUF418; cl12135 291331007137 Protein of unknown function (DUF418); Region: DUF418; cl12135 291331007138 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 291331007139 NlpC/P60 family; Region: NLPC_P60; cl11438 291331007140 NlpC/P60 family; Region: NLPC_P60; cl11438 291331007141 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 291331007142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331007143 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 291331007144 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016 291331007145 Alkaline phosphatase homologues; Region: alkPPc; smart00098 291331007146 active site 291331007147 dimer interface [polypeptide binding]; other site 291331007148 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 291331007149 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 291331007150 Ligand Binding Site [chemical binding]; other site 291331007151 TilS substrate binding domain; Region: TilS; pfam09179 291331007152 B3/4 domain; Region: B3_4; cl11458 291331007153 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 291331007154 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 291331007155 substrate binding pocket [chemical binding]; other site 291331007156 chain length determination region; other site 291331007157 substrate-Mg2+ binding site; other site 291331007158 catalytic residues [active] 291331007159 aspartate-rich region 1; other site 291331007160 active site lid residues [active] 291331007161 aspartate-rich region 2; other site 291331007162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 291331007163 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 291331007164 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 291331007165 Protein of unknown function (DUF615); Region: DUF615; cl01147 291331007166 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 291331007167 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 291331007168 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331007169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007170 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331007171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007172 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331007173 TIGR02099 family protein; Region: TIGR02099 291331007174 ribonuclease G; Provisional; Region: PRK11712 291331007175 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 291331007176 homodimer interface [polypeptide binding]; other site 291331007177 oligonucleotide binding site [chemical binding]; other site 291331007178 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 291331007179 active site 291331007180 dimer interface [polypeptide binding]; other site 291331007181 Protein of unknown function (DUF541); Region: SIMPL; cl01077 291331007182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007183 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331007184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007185 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331007186 Gram-negative bacterial tonB protein; Region: TonB; cl10048 291331007187 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 291331007188 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 291331007189 Domain of unknown function DUF143; Region: DUF143; cl00519 291331007191 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 291331007192 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 291331007193 Lipopolysaccharide-assembly; Region: LptE; cl01125 291331007194 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 291331007195 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 291331007196 HIGH motif; other site 291331007197 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291331007198 active site 291331007199 KMSKS motif; other site 291331007200 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 291331007201 tRNA binding surface [nucleotide binding]; other site 291331007202 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 291331007203 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 291331007204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007205 Domain of unknown function (DUF378); Region: DUF378; cl00943 291331007206 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 291331007207 active site 291331007208 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331007209 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331007210 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331007211 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331007212 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331007213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007214 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 291331007215 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 291331007216 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 291331007217 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331007218 Transposase domain (DUF772); Region: DUF772; cl12084 291331007219 Transposase domain (DUF772); Region: DUF772; cl12084 291331007220 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331007221 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331007222 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331007223 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331007224 Integrase core domain; Region: rve; cl01316 291331007225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007226 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331007227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007228 H-NS histone family; Region: Histone_HNS; pfam00816 291331007229 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 291331007231 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 291331007232 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331007233 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331007234 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 291331007235 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 291331007236 active site 291331007237 catalytic triad [active] 291331007238 oxyanion hole [active] 291331007239 Autotransporter beta-domain; Region: Autotransporter; cl02365 291331007240 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 291331007241 thiS-thiF/thiG interaction site; other site 291331007242 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 291331007243 ThiS interaction site; other site 291331007244 putative active site [active] 291331007245 tetramer interface [polypeptide binding]; other site 291331007246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331007247 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 291331007248 transmembrane helices; other site 291331007249 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 291331007250 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 291331007251 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 291331007252 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 291331007253 iron-sulfur cluster [ion binding]; other site 291331007254 [2Fe-2S] cluster binding site [ion binding]; other site 291331007255 Transposase domain (DUF772); Region: DUF772; cl12084 291331007256 Integrase core domain; Region: rve; cl01316 291331007257 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 291331007258 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 291331007259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007261 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 291331007262 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 291331007263 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 291331007264 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331007265 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331007266 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 291331007267 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 291331007268 Zn binding site [ion binding]; other site 291331007269 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 291331007270 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 291331007271 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 291331007272 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 291331007273 CysD dimerization site [polypeptide binding]; other site 291331007274 G1 box; other site 291331007275 putative GEF interaction site [polypeptide binding]; other site 291331007276 GTP/Mg2+ binding site [chemical binding]; other site 291331007277 Switch I region; other site 291331007278 G2 box; other site 291331007279 G3 box; other site 291331007280 Switch II region; other site 291331007281 G4 box; other site 291331007282 G5 box; other site 291331007283 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 291331007284 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 291331007285 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 291331007286 ligand-binding site [chemical binding]; other site 291331007287 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 291331007288 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 291331007289 Active Sites [active] 291331007290 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 291331007291 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 291331007292 sulfite reductase subunit beta; Provisional; Region: PRK13504 291331007293 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 291331007294 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 291331007295 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 291331007296 Active Sites [active] 291331007297 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 291331007298 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 291331007299 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 291331007300 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331007301 N-terminal plug; other site 291331007302 ligand-binding site [chemical binding]; other site 291331007303 GAF domain; Region: GAF; cl00853 291331007304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 291331007305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331007306 ATP binding site [chemical binding]; other site 291331007307 Mg2+ binding site [ion binding]; other site 291331007308 G-X-G motif; other site 291331007309 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12680 291331007310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331007311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331007312 dimerization interface [polypeptide binding]; other site 291331007313 siroheme synthase; Provisional; Region: cysG; PRK10637 291331007314 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 291331007315 cysteine synthases; Region: cysKM; TIGR01136 291331007316 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 291331007317 dimer interface [polypeptide binding]; other site 291331007318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331007319 catalytic residue [active] 291331007320 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 291331007321 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 291331007322 putative ADP-ribose binding site [chemical binding]; other site 291331007323 putative active site [active] 291331007324 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 291331007325 active site 291331007326 intersubunit interface [polypeptide binding]; other site 291331007327 catalytic residue [active] 291331007328 pyruvate kinase; Provisional; Region: PRK05826 291331007329 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 291331007330 domain interfaces; other site 291331007331 active site 291331007332 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 291331007333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 291331007334 motif II; other site 291331007335 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 291331007336 substrate binding site [chemical binding]; other site 291331007337 hinge regions; other site 291331007338 ADP binding site [chemical binding]; other site 291331007339 catalytic site [active] 291331007340 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 291331007342 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cl00470 291331007343 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 291331007344 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 291331007345 tetramer interface [polypeptide binding]; other site 291331007346 heme binding pocket [chemical binding]; other site 291331007347 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 291331007348 domain interactions; other site 291331007349 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 291331007350 PAS fold; Region: PAS_4; pfam08448 291331007351 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 291331007352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 291331007353 Transposase domain (DUF772); Region: DUF772; cl12084 291331007354 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 291331007355 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331007356 OPT oligopeptide transporter protein; Region: OPT; cl14607 291331007357 putative oligopeptide transporter, OPT family; Region: TIGR00733 291331007358 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 291331007359 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 291331007360 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 291331007361 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 291331007362 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 291331007363 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 291331007364 generic binding surface I; other site 291331007365 generic binding surface II; other site 291331007366 DNA Polymerase Y-family; Region: PolY_like; cd03468 291331007367 active site 291331007368 DNA binding site [nucleotide binding] 291331007369 Cell division inhibitor SulA; Region: SulA; cl01880 291331007370 LexA repressor; Provisional; Region: PRK12423 291331007371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331007372 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 291331007373 Catalytic site [active] 291331007374 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 291331007375 Fic/DOC family; Region: Fic; cl00960 291331007376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007377 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331007378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007379 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 291331007380 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 291331007381 catalytic core [active] 291331007382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 291331007383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 291331007384 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 291331007385 active site 291331007386 ATP binding site [chemical binding]; other site 291331007387 substrate binding site [chemical binding]; other site 291331007388 activation loop (A-loop); other site 291331007389 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 291331007390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 291331007391 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 291331007393 HsdM N-terminal domain; Region: HsdM_N; pfam12161 291331007394 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 291331007395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331007396 Uncharacterized conserved protein [Function unknown]; Region: COG4127 291331007397 Restriction endonuclease; Region: Mrr_cat; cl00747 291331007398 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 291331007399 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 291331007400 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 291331007401 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 291331007402 ATP binding site [chemical binding]; other site 291331007403 putative Mg++ binding site [ion binding]; other site 291331007404 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 291331007405 Abi-like protein; Region: Abi_2; cl01988 291331007406 HsdM N-terminal domain; Region: HsdM_N; pfam12161 291331007407 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 291331007408 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 291331007409 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 291331007410 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 291331007411 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 291331007412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 291331007413 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 291331007414 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 291331007415 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331007416 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 291331007417 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331007418 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 291331007419 Clp amino terminal domain; Region: Clp_N; pfam02861 291331007420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331007421 Walker A motif; other site 291331007422 ATP binding site [chemical binding]; other site 291331007423 Walker B motif; other site 291331007424 arginine finger; other site 291331007425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331007426 Walker A motif; other site 291331007427 ATP binding site [chemical binding]; other site 291331007428 Walker B motif; other site 291331007429 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 291331007430 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 291331007431 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 291331007432 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 291331007433 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 291331007434 Protein of unknown function (DUF796); Region: DUF796; cl01226 291331007435 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 291331007436 Protein of unknown function (DUF877); Region: DUF877; pfam05943 291331007437 Protein of unknown function (DUF770); Region: DUF770; cl01402 291331007438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331007439 binding surface 291331007440 TPR motif; other site 291331007441 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 291331007442 Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406 291331007443 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 291331007444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 291331007445 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331007446 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331007447 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 291331007448 catalytic residue [active] 291331007449 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 291331007450 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331007451 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331007452 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 291331007453 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331007454 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331007455 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331007456 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331007457 Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406 291331007458 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 291331007459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 291331007461 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331007462 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 291331007463 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 291331007464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 291331007465 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331007466 hypothetical protein; Provisional; Region: PRK11383 291331007467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 291331007468 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 291331007469 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331007470 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 291331007471 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 291331007472 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 291331007473 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 291331007474 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 291331007475 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 291331007476 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 291331007477 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 291331007478 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 291331007479 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 291331007480 ligand binding site [chemical binding]; other site 291331007481 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 291331007482 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 291331007483 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 291331007484 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 291331007485 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 291331007486 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 291331007487 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331007488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331007489 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 291331007490 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331007491 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 291331007492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 291331007493 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 291331007494 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 291331007495 endonuclease III; Region: ENDO3c; smart00478 291331007496 minor groove reading motif; other site 291331007497 helix-hairpin-helix signature motif; other site 291331007498 substrate binding pocket [chemical binding]; other site 291331007499 active site 291331007500 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 291331007501 putative hydrophobic ligand binding site [chemical binding]; other site 291331007502 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 291331007503 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 291331007504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331007505 active site 291331007506 phosphorylation site [posttranslational modification] 291331007507 intermolecular recognition site; other site 291331007508 dimerization interface [polypeptide binding]; other site 291331007509 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 291331007510 DNA binding residues [nucleotide binding] 291331007511 dimerization interface [polypeptide binding]; other site 291331007512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 291331007513 Histidine kinase; Region: HisKA_3; pfam07730 291331007514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 291331007515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331007516 septum formation inhibitor; Reviewed; Region: minC; PRK04596 291331007517 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 291331007518 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 291331007519 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 291331007520 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 291331007521 Switch I; other site 291331007522 Switch II; other site 291331007523 Septum formation topological specificity factor MinE; Region: MinE; cl00538 291331007524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 291331007525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331007526 dimer interface [polypeptide binding]; other site 291331007527 phosphorylation site [posttranslational modification] 291331007528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331007529 ATP binding site [chemical binding]; other site 291331007530 Mg2+ binding site [ion binding]; other site 291331007531 G-X-G motif; other site 291331007532 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 291331007533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331007534 active site 291331007535 phosphorylation site [posttranslational modification] 291331007536 intermolecular recognition site; other site 291331007537 dimerization interface [polypeptide binding]; other site 291331007538 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331007539 DNA binding site [nucleotide binding] 291331007540 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 291331007541 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 291331007542 active site 291331007543 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 291331007544 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 291331007545 Sulfatase; Region: Sulfatase; cl10460 291331007546 Angiotensin-converting enzyme; Region: Peptidase_M2; pfam01401 291331007547 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 291331007548 active site 291331007549 Zn binding site [ion binding]; other site 291331007550 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 291331007551 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 291331007552 putative active site [active] 291331007553 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 291331007554 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 291331007555 Walker A/P-loop; other site 291331007556 ATP binding site [chemical binding]; other site 291331007557 Q-loop/lid; other site 291331007558 ABC transporter signature motif; other site 291331007559 Walker B; other site 291331007560 D-loop; other site 291331007561 H-loop/switch region; other site 291331007562 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 291331007563 glycine dehydrogenase; Provisional; Region: PRK05367 291331007564 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291331007565 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331007566 catalytic residue [active] 291331007567 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 291331007568 tetramer interface [polypeptide binding]; other site 291331007569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331007570 catalytic residue [active] 291331007571 VRR-NUC domain; Region: VRR_NUC; pfam08774 291331007572 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 291331007573 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 291331007574 Integrase core domain; Region: rve; cl01316 291331007575 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331007576 Integrase core domain; Region: rve; cl01316 291331007577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331007579 Integrase core domain; Region: rve; cl01316 291331007580 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 291331007581 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 291331007582 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 291331007583 alphaNTD homodimer interface [polypeptide binding]; other site 291331007584 alphaNTD - beta interaction site [polypeptide binding]; other site 291331007585 alphaNTD - beta' interaction site [polypeptide binding]; other site 291331007586 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 291331007587 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 291331007588 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 291331007589 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 291331007590 RNA binding surface [nucleotide binding]; other site 291331007591 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 291331007592 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 291331007593 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 291331007594 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 291331007595 SecY translocase; Region: SecY; pfam00344 291331007596 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 291331007597 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 291331007598 23S rRNA binding site [nucleotide binding]; other site 291331007599 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 291331007600 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 291331007601 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 291331007602 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 291331007603 5S rRNA interface [nucleotide binding]; other site 291331007604 23S rRNA interface [nucleotide binding]; other site 291331007605 L5 interface [polypeptide binding]; other site 291331007606 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 291331007607 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 291331007608 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 291331007609 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 291331007610 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 291331007611 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 291331007612 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 291331007613 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 291331007614 KOW motif; Region: KOW; cl00354 291331007615 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 291331007616 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 291331007617 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 291331007618 putative translocon interaction site; other site 291331007619 23S rRNA interface [nucleotide binding]; other site 291331007620 signal recognition particle (SRP54) interaction site; other site 291331007621 L23 interface [polypeptide binding]; other site 291331007622 trigger factor interaction site; other site 291331007623 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 291331007624 23S rRNA interface [nucleotide binding]; other site 291331007625 5S rRNA interface [nucleotide binding]; other site 291331007626 putative antibiotic binding site [chemical binding]; other site 291331007627 L25 interface [polypeptide binding]; other site 291331007628 L27 interface [polypeptide binding]; other site 291331007629 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 291331007630 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 291331007631 G-X-X-G motif; other site 291331007632 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 291331007633 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 291331007634 putative translocon binding site; other site 291331007635 protein-rRNA interface [nucleotide binding]; other site 291331007636 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 291331007637 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 291331007638 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 291331007639 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 291331007640 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 291331007641 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 291331007642 elongation factor Tu; Reviewed; Region: PRK00049 291331007643 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 291331007644 G1 box; other site 291331007645 GEF interaction site [polypeptide binding]; other site 291331007646 GTP/Mg2+ binding site [chemical binding]; other site 291331007647 Switch I region; other site 291331007648 G2 box; other site 291331007649 G3 box; other site 291331007650 Switch II region; other site 291331007651 G4 box; other site 291331007652 G5 box; other site 291331007653 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 291331007654 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 291331007655 Antibiotic Binding Site [chemical binding]; other site 291331007656 elongation factor G; Reviewed; Region: PRK00007 291331007657 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 291331007658 G1 box; other site 291331007659 putative GEF interaction site [polypeptide binding]; other site 291331007660 GTP/Mg2+ binding site [chemical binding]; other site 291331007661 Switch I region; other site 291331007662 G2 box; other site 291331007663 G3 box; other site 291331007664 Switch II region; other site 291331007665 G4 box; other site 291331007666 G5 box; other site 291331007667 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 291331007668 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 291331007669 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 291331007670 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 291331007671 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 291331007672 S17 interaction site [polypeptide binding]; other site 291331007673 S8 interaction site; other site 291331007674 16S rRNA interaction site [nucleotide binding]; other site 291331007675 streptomycin interaction site [chemical binding]; other site 291331007676 23S rRNA interaction site [nucleotide binding]; other site 291331007677 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 291331007678 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 291331007679 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 291331007680 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 291331007681 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 291331007682 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 291331007683 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 291331007684 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 291331007685 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 291331007686 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 291331007687 DNA binding site [nucleotide binding] 291331007688 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 291331007689 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 291331007690 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 291331007691 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 291331007692 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 291331007693 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 291331007694 RPB11 interaction site [polypeptide binding]; other site 291331007695 RPB12 interaction site [polypeptide binding]; other site 291331007696 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 291331007697 RPB3 interaction site [polypeptide binding]; other site 291331007698 RPB1 interaction site [polypeptide binding]; other site 291331007699 RPB11 interaction site [polypeptide binding]; other site 291331007700 RPB10 interaction site [polypeptide binding]; other site 291331007701 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 291331007702 core dimer interface [polypeptide binding]; other site 291331007703 peripheral dimer interface [polypeptide binding]; other site 291331007704 L10 interface [polypeptide binding]; other site 291331007705 L11 interface [polypeptide binding]; other site 291331007706 putative EF-Tu interaction site [polypeptide binding]; other site 291331007707 putative EF-G interaction site [polypeptide binding]; other site 291331007708 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 291331007709 23S rRNA interface [nucleotide binding]; other site 291331007710 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 291331007711 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 291331007712 mRNA/rRNA interface [nucleotide binding]; other site 291331007713 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 291331007714 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 291331007715 23S rRNA interface [nucleotide binding]; other site 291331007716 L7/L12 interface [polypeptide binding]; other site 291331007717 putative thiostrepton binding site; other site 291331007718 L25 interface [polypeptide binding]; other site 291331007719 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 291331007720 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 291331007721 putative homodimer interface [polypeptide binding]; other site 291331007722 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 291331007723 elongation factor Tu; Reviewed; Region: PRK00049 291331007724 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 291331007725 G1 box; other site 291331007726 GEF interaction site [polypeptide binding]; other site 291331007727 GTP/Mg2+ binding site [chemical binding]; other site 291331007728 Switch I region; other site 291331007729 G2 box; other site 291331007730 G3 box; other site 291331007731 Switch II region; other site 291331007732 G4 box; other site 291331007733 G5 box; other site 291331007734 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 291331007735 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 291331007736 Antibiotic Binding Site [chemical binding]; other site 291331007737 GTP-binding protein YchF; Reviewed; Region: PRK09601 291331007738 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 291331007739 G1 box; other site 291331007740 GTP/Mg2+ binding site [chemical binding]; other site 291331007741 Switch I region; other site 291331007742 G2 box; other site 291331007743 Switch II region; other site 291331007744 G3 box; other site 291331007745 G4 box; other site 291331007746 G5 box; other site 291331007747 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 291331007748 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 291331007749 putative active site [active] 291331007750 catalytic residue [active] 291331007751 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 291331007752 5S rRNA interface [nucleotide binding]; other site 291331007753 CTC domain interface; other site 291331007754 L16 interface [polypeptide binding]; other site 291331007755 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 291331007756 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 291331007757 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 291331007758 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 291331007759 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 291331007760 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 291331007761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331007762 TPR motif; other site 291331007763 binding surface 291331007764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331007765 binding surface 291331007766 TPR motif; other site 291331007767 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 291331007768 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 291331007769 tRNA; other site 291331007770 putative tRNA binding site [nucleotide binding]; other site 291331007771 putative NADP binding site [chemical binding]; other site 291331007772 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 291331007773 peptide chain release factor 1; Validated; Region: prfA; PRK00591 291331007774 RF-1 domain; Region: RF-1; cl02875 291331007775 RF-1 domain; Region: RF-1; cl02875 291331007776 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 291331007777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331007778 binding surface 291331007779 TPR motif; other site 291331007780 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 291331007781 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 291331007782 MPT binding site; other site 291331007783 trimer interface [polypeptide binding]; other site 291331007784 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 291331007785 Acylphosphatase; Region: Acylphosphatase; cl00551 291331007786 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 291331007787 catalytic residues [active] 291331007788 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 291331007789 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 291331007790 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 291331007791 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 291331007792 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 291331007793 active site/substrate binding site [active] 291331007794 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 291331007795 putative deacylase active site [active] 291331007796 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 291331007797 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 291331007798 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 291331007799 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 291331007800 homodimer interface [polypeptide binding]; other site 291331007801 substrate-cofactor binding pocket; other site 291331007802 catalytic residue [active] 291331007803 Domain of unknown function DUF59; Region: DUF59; cl00941 291331007804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007805 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 291331007806 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 291331007807 RNA polymerase factor sigma-70; Validated; Region: PRK09047 291331007808 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 291331007809 DNA binding residues [nucleotide binding] 291331007810 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 291331007811 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 291331007812 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 291331007813 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 291331007814 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331007815 Transposase domain (DUF772); Region: DUF772; cl12084 291331007816 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331007817 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 291331007818 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 291331007819 putative FMN binding site [chemical binding]; other site 291331007820 5'-3' exonuclease; Region: 53EXOc; smart00475 291331007821 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 291331007822 active site 291331007823 metal binding site 1 [ion binding]; metal-binding site 291331007824 putative 5' ssDNA interaction site; other site 291331007825 metal binding site 3; metal-binding site 291331007826 metal binding site 2 [ion binding]; metal-binding site 291331007827 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 291331007828 putative DNA binding site [nucleotide binding]; other site 291331007829 putative metal binding site [ion binding]; other site 291331007830 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 291331007831 ADP-ribose binding site [chemical binding]; other site 291331007832 dimer interface [polypeptide binding]; other site 291331007833 active site 291331007834 nudix motif; other site 291331007835 metal binding site [ion binding]; metal-binding site 291331007836 N-formylglutamate amidohydrolase; Region: FGase; cl01522 291331007837 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 291331007838 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331007839 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 291331007840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331007841 S-adenosylmethionine binding site [chemical binding]; other site 291331007842 peroxiredoxin; Region: AhpC; TIGR03137 291331007843 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 291331007844 dimer interface [polypeptide binding]; other site 291331007845 decamer (pentamer of dimers) interface [polypeptide binding]; other site 291331007846 catalytic triad [active] 291331007847 peroxidatic and resolving cysteines [active] 291331007848 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 291331007849 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 291331007850 catalytic residue [active] 291331007851 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 291331007852 catalytic residues [active] 291331007853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331007854 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 291331007855 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331007856 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 291331007857 dimerization interface [polypeptide binding]; other site 291331007858 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 291331007859 C-term; Region: GreA_GreB; pfam01272 291331007860 transaldolase-like protein; Provisional; Region: PTZ00411 291331007861 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 291331007862 active site 291331007863 dimer interface [polypeptide binding]; other site 291331007864 catalytic residue [active] 291331007865 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331007866 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331007867 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331007868 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 291331007869 conserved cys residue [active] 291331007870 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 291331007871 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 291331007872 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331007873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007875 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 291331007876 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 291331007877 GSH binding site [chemical binding]; other site 291331007878 catalytic residues [active] 291331007879 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 291331007880 Peptidase family M48; Region: Peptidase_M48; cl12018 291331007881 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 291331007882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331007883 active site 291331007884 phosphorylation site [posttranslational modification] 291331007885 intermolecular recognition site; other site 291331007886 dimerization interface [polypeptide binding]; other site 291331007887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331007888 DNA binding site [nucleotide binding] 291331007889 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 291331007890 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 291331007891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331007892 dimer interface [polypeptide binding]; other site 291331007893 phosphorylation site [posttranslational modification] 291331007894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331007895 ATP binding site [chemical binding]; other site 291331007896 Mg2+ binding site [ion binding]; other site 291331007897 G-X-G motif; other site 291331007898 polyphosphate kinase; Provisional; Region: PRK05443 291331007899 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 291331007900 putative domain interface [polypeptide binding]; other site 291331007901 putative active site [active] 291331007902 catalytic site [active] 291331007903 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 291331007904 putative domain interface [polypeptide binding]; other site 291331007905 putative active site [active] 291331007906 catalytic site [active] 291331007907 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 291331007908 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 291331007909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 291331007910 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 291331007911 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 291331007912 active site 291331007913 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 291331007914 putative active site [active] 291331007915 putative metal binding site [ion binding]; other site 291331007916 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 291331007917 dinuclear metal binding motif [ion binding]; other site 291331007918 amidophosphoribosyltransferase; Provisional; Region: PRK09246 291331007919 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 291331007920 active site 291331007921 tetramer interface [polypeptide binding]; other site 291331007922 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 291331007923 Colicin V production protein; Region: Colicin_V; cl00567 291331007924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 291331007925 Sporulation related domain; Region: SPOR; cl10051 291331007926 Sporulation related domain; Region: SPOR; cl10051 291331007927 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 291331007928 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 291331007929 catalytic core [active] 291331007930 Peptidase S46; Region: Peptidase_S46; pfam10459 291331007931 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 291331007932 Phosphoesterase family; Region: Phosphoesterase; cl10627 291331007933 Domain of unknown function (DUF756); Region: DUF756; pfam05506 291331007934 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 291331007935 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331007936 N-terminal plug; other site 291331007937 ligand-binding site [chemical binding]; other site 291331007938 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 291331007939 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 291331007940 NAD(P) binding site [chemical binding]; other site 291331007941 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 291331007942 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 291331007943 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296 291331007944 Walker A/P-loop; other site 291331007945 ATP binding site [chemical binding]; other site 291331007946 Q-loop/lid; other site 291331007947 ABC transporter signature motif; other site 291331007948 Walker B; other site 291331007949 D-loop; other site 291331007950 H-loop/switch region; other site 291331007951 TOBE-like domain; Region: TOBE_3; pfam12857 291331007952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 291331007953 dimer interface [polypeptide binding]; other site 291331007954 conserved gate region; other site 291331007955 putative PBP binding loops; other site 291331007956 ABC-ATPase subunit interface; other site 291331007957 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 291331007958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 291331007959 dimer interface [polypeptide binding]; other site 291331007960 conserved gate region; other site 291331007961 putative PBP binding loops; other site 291331007962 ABC-ATPase subunit interface; other site 291331007963 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331007964 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 291331007965 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 291331007966 substrate-cofactor binding pocket; other site 291331007967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331007968 catalytic residue [active] 291331007969 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 291331007970 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 291331007971 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 291331007972 active site 291331007973 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 291331007974 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 291331007975 putative NAD(P) binding site [chemical binding]; other site 291331007976 dimer interface [polypeptide binding]; other site 291331007977 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 291331007978 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 291331007979 active site 291331007980 FMN binding site [chemical binding]; other site 291331007981 2,4-decadienoyl-CoA binding site; other site 291331007982 catalytic residue [active] 291331007983 4Fe-4S cluster binding site [ion binding]; other site 291331007984 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331007985 Integrase core domain; Region: rve; cl01316 291331007986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007987 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331007988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331007989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331007990 ATP binding site [chemical binding]; other site 291331007991 Mg2+ binding site [ion binding]; other site 291331007992 G-X-G motif; other site 291331007993 Response regulator receiver domain; Region: Response_reg; pfam00072 291331007994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331007995 active site 291331007996 phosphorylation site [posttranslational modification] 291331007997 intermolecular recognition site; other site 291331007998 dimerization interface [polypeptide binding]; other site 291331007999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331008000 active site 291331008001 phosphorylation site [posttranslational modification] 291331008002 intermolecular recognition site; other site 291331008003 dimerization interface [polypeptide binding]; other site 291331008004 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH)...; Region: GST_N_1; cd03043 291331008005 putative C-terminal domain interface [polypeptide binding]; other site 291331008006 putative GSH binding site (G-site) [chemical binding]; other site 291331008007 putative dimer interface [polypeptide binding]; other site 291331008008 GST_C family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous...; Region: GST_C_3; cd03194 291331008009 putative substrate binding pocket (H-site) [chemical binding]; other site 291331008010 putative N-terminal domain interface [polypeptide binding]; other site 291331008011 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 291331008012 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291331008013 active site 291331008014 HIGH motif; other site 291331008015 nucleotide binding site [chemical binding]; other site 291331008016 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 291331008017 active site 291331008018 KMSKS motif; other site 291331008019 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 291331008020 Integrase core domain; Region: rve; cl01316 291331008021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008022 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331008023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008025 EamA-like transporter family; Region: EamA; cl01037 291331008026 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 291331008027 nucleoside/Zn binding site; other site 291331008028 dimer interface [polypeptide binding]; other site 291331008029 catalytic motif [active] 291331008030 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 291331008031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331008032 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 291331008033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331008034 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 291331008035 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 291331008036 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cl09501 291331008037 pseudo EF-hand loop; other site 291331008038 peptide binding pocket; other site 291331008039 Ca2+ binding site [ion binding]; other site 291331008040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331008041 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 291331008042 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 291331008043 substrate binding site [chemical binding]; other site 291331008044 oxyanion hole (OAH) forming residues; other site 291331008045 trimer interface [polypeptide binding]; other site 291331008046 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 291331008047 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 291331008048 NAD binding site [chemical binding]; other site 291331008049 catalytic residues [active] 291331008050 acyl-CoA synthetase; Validated; Region: PRK09088 291331008051 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 291331008052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 291331008053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331008054 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331008055 dimerization interface [polypeptide binding]; other site 291331008056 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 291331008057 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 291331008058 putative active site [active] 291331008059 Fe(II) binding site [ion binding]; other site 291331008060 putative dimer interface [polypeptide binding]; other site 291331008061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331008062 DNA-binding site [nucleotide binding]; DNA binding site 291331008063 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331008064 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331008065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331008066 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 291331008067 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Validated; Region: PRK08773 291331008068 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331008069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331008070 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 291331008071 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 291331008072 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 291331008073 organic solvent tolerance protein; Provisional; Region: PRK04423 291331008074 Organic solvent tolerance protein; Region: OstA_C; pfam04453 291331008075 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 291331008076 SurA N-terminal domain; Region: SurA_N; pfam09312 291331008077 PPIC-type PPIASE domain; Region: Rotamase; cl08278 291331008078 PPIC-type PPIASE domain; Region: Rotamase; cl08278 291331008079 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 291331008080 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 291331008081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331008082 Protein of unknown function (DUF525); Region: DUF525; cl01119 291331008083 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 291331008084 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 291331008085 active site 291331008086 metal binding site [ion binding]; metal-binding site 291331008087 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 291331008088 folate binding site [chemical binding]; other site 291331008089 NADP+ binding site [chemical binding]; other site 291331008090 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 291331008091 dimerization interface [polypeptide binding]; other site 291331008092 active site 291331008093 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 291331008094 Domain of unknown function (DUF477); Region: DUF477; cl01535 291331008095 Domain of unknown function (DUF477); Region: DUF477; cl01535 291331008096 LemA family; Region: LemA; cl00742 291331008097 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 291331008098 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 291331008099 active site 291331008100 oxyanion hole [active] 291331008101 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 291331008102 catalytic triad [active] 291331008103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008104 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331008105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008106 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 291331008107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331008108 dimer interface [polypeptide binding]; other site 291331008109 phosphorylation site [posttranslational modification] 291331008110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331008111 ATP binding site [chemical binding]; other site 291331008112 Mg2+ binding site [ion binding]; other site 291331008113 G-X-G motif; other site 291331008114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331008115 active site 291331008116 phosphorylation site [posttranslational modification] 291331008117 intermolecular recognition site; other site 291331008118 dimerization interface [polypeptide binding]; other site 291331008119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331008120 DNA binding site [nucleotide binding] 291331008121 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 291331008122 active site 291331008123 catalytic triad [active] 291331008124 oxyanion hole [active] 291331008125 switch loop; other site 291331008126 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 291331008127 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 291331008128 Walker A/P-loop; other site 291331008129 ATP binding site [chemical binding]; other site 291331008130 Q-loop/lid; other site 291331008131 ABC transporter signature motif; other site 291331008132 Walker B; other site 291331008133 D-loop; other site 291331008134 H-loop/switch region; other site 291331008135 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 291331008136 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 291331008137 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 291331008138 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 291331008140 Protein of unknown function, DUF486; Region: DUF486; cl01236 291331008141 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 291331008142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008143 Hemin uptake protein hemP; Region: hemP; cl10043 291331008144 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 291331008145 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 291331008146 active site 291331008147 catalytic tetrad [active] 291331008149 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 291331008150 substrate binding site [chemical binding]; other site 291331008151 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 291331008152 dimer interface [polypeptide binding]; other site 291331008153 ATP binding site [chemical binding]; other site 291331008154 Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306 291331008155 Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307 291331008156 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 291331008157 putative metal binding site [ion binding]; other site 291331008158 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 291331008159 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 291331008160 FMN binding site [chemical binding]; other site 291331008161 active site 291331008162 catalytic residues [active] 291331008163 substrate binding site [chemical binding]; other site 291331008164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331008165 S-adenosylmethionine binding site [chemical binding]; other site 291331008166 S-adenosylmethionine synthetase; Validated; Region: PRK05250 291331008167 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 291331008168 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 291331008169 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 291331008170 phosphoanhydride phosphorylase; Provisional; Region: PRK10172 291331008171 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 291331008172 catalytic core [active] 291331008173 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331008174 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331008175 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331008176 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331008177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 291331008178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 291331008179 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 291331008180 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 291331008181 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331008182 Adenosylhomocysteinase; Provisional; Region: PTZ00075 291331008183 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 291331008184 oligomerization interface [polypeptide binding]; other site 291331008185 active site 291331008186 NAD+ binding site [chemical binding]; other site 291331008187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331008188 S-adenosylmethionine binding site [chemical binding]; other site 291331008189 sulfotransferase; Region: PLN02164 291331008190 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 291331008191 Protein of unknown function (DUF3228); Region: DUF3228; pfam11539 291331008192 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 291331008193 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 291331008194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331008195 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 291331008196 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 291331008197 catalytic residues [active] 291331008198 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 291331008199 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 291331008200 NAD(P) binding site [chemical binding]; other site 291331008201 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 291331008202 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 291331008203 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 291331008204 FAD binding site [chemical binding]; other site 291331008205 hypothetical protein; Provisional; Region: PRK08999 291331008206 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 291331008207 active site 291331008208 8-oxo-dGMP binding site [chemical binding]; other site 291331008209 nudix motif; other site 291331008210 metal binding site [ion binding]; metal-binding site 291331008211 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 291331008212 thiamine phosphate binding site [chemical binding]; other site 291331008213 active site 291331008214 pyrophosphate binding site [ion binding]; other site 291331008215 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_17; cd08356 291331008216 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 291331008217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 291331008218 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 291331008219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331008220 nucleotide binding region [chemical binding]; other site 291331008221 ATP-binding site [chemical binding]; other site 291331008222 SEC-C motif; Region: SEC-C; cl12132 291331008223 Peptidase family M23; Region: Peptidase_M23; pfam01551 291331008224 Protein of unknown function (DUF721); Region: DUF721; cl02324 291331008225 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 291331008226 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 291331008227 cell division protein FtsZ; Validated; Region: PRK09330 291331008228 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 291331008229 nucleotide binding site [chemical binding]; other site 291331008230 SulA interaction site; other site 291331008231 cell division protein FtsA; Region: ftsA; TIGR01174 291331008232 Cell division protein FtsA; Region: FtsA; cl11496 291331008233 Cell division protein FtsA; Region: FtsA; cl11496 291331008234 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 291331008235 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 291331008236 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331008237 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 291331008238 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 291331008239 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 291331008240 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 291331008241 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 291331008242 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 291331008243 active site 291331008244 homodimer interface [polypeptide binding]; other site 291331008245 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 291331008246 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 291331008247 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 291331008248 Mg++ binding site [ion binding]; other site 291331008249 putative catalytic motif [active] 291331008250 putative substrate binding site [chemical binding]; other site 291331008251 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 291331008252 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 291331008253 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 291331008254 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 291331008255 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 291331008256 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 291331008257 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 291331008258 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 291331008259 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 291331008260 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 291331008261 Septum formation initiator; Region: DivIC; cl11433 291331008262 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 291331008263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331008264 cell division protein MraZ; Reviewed; Region: PRK00326 291331008265 MraZ protein; Region: MraZ; pfam02381 291331008266 MraZ protein; Region: MraZ; pfam02381 291331008267 Protein of unknown function (DUF833); Region: DUF833; cl01315 291331008268 CcdB protein; Region: CcdB; cl03380 291331008269 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 291331008270 Predicted methyltransferases [General function prediction only]; Region: COG0313 291331008271 LppC putative lipoprotein; Region: LppC; pfam04348 291331008272 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 291331008273 putative ligand binding site [chemical binding]; other site 291331008274 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 291331008275 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 291331008276 FAD binding domain; Region: FAD_binding_4; pfam01565 291331008277 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 291331008278 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 291331008279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331008280 active site 291331008281 phosphorylation site [posttranslational modification] 291331008282 intermolecular recognition site; other site 291331008283 dimerization interface [polypeptide binding]; other site 291331008284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331008285 DNA binding site [nucleotide binding] 291331008286 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 291331008287 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 291331008288 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 291331008289 Ligand Binding Site [chemical binding]; other site 291331008290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331008291 dimer interface [polypeptide binding]; other site 291331008292 phosphorylation site [posttranslational modification] 291331008293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331008294 ATP binding site [chemical binding]; other site 291331008295 Mg2+ binding site [ion binding]; other site 291331008296 G-X-G motif; other site 291331008297 K+-transporting ATPase, c chain; Region: KdpC; cl00944 291331008298 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 291331008299 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 291331008300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 291331008301 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 291331008302 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 291331008303 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 291331008304 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 291331008305 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 291331008306 thiamine monophosphate kinase; Provisional; Region: PRK05731 291331008307 ATP binding site [chemical binding]; other site 291331008308 dimerization interface [polypeptide binding]; other site 291331008309 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 291331008310 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 291331008311 homopentamer interface [polypeptide binding]; other site 291331008312 active site 291331008313 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 291331008314 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 291331008315 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 291331008316 dimerization interface [polypeptide binding]; other site 291331008317 active site 291331008318 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 291331008319 Lumazine binding domain; Region: Lum_binding; pfam00677 291331008320 Lumazine binding domain; Region: Lum_binding; pfam00677 291331008321 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 291331008322 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 291331008323 catalytic motif [active] 291331008324 Zn binding site [ion binding]; other site 291331008325 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 291331008326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 291331008327 Coenzyme A binding pocket [chemical binding]; other site 291331008328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331008329 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 291331008330 ATP cone domain; Region: ATP-cone; pfam03477 291331008331 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 291331008332 dimer interface [polypeptide binding]; other site 291331008333 glycine-pyridoxal phosphate binding site [chemical binding]; other site 291331008334 active site 291331008335 folate binding site [chemical binding]; other site 291331008336 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 291331008337 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 291331008338 N-terminal plug; other site 291331008339 ligand-binding site [chemical binding]; other site 291331008340 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 291331008341 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 291331008342 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331008343 Walker A/P-loop; other site 291331008344 ATP binding site [chemical binding]; other site 291331008345 Q-loop/lid; other site 291331008346 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 291331008347 ABC transporter signature motif; other site 291331008348 Walker B; other site 291331008349 D-loop; other site 291331008350 ABC transporter; Region: ABC_tran_2; pfam12848 291331008351 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 291331008352 Predicted esterase [General function prediction only]; Region: COG0627 291331008353 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331008354 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 291331008355 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 291331008356 substrate binding site [chemical binding]; other site 291331008357 catalytic Zn binding site [ion binding]; other site 291331008358 NAD binding site [chemical binding]; other site 291331008359 structural Zn binding site [ion binding]; other site 291331008360 dimer interface [polypeptide binding]; other site 291331008361 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 291331008362 putative metal binding site [ion binding]; other site 291331008363 putative homotetramer interface [polypeptide binding]; other site 291331008364 putative homodimer interface [polypeptide binding]; other site 291331008365 putative homodimer-homodimer interface [polypeptide binding]; other site 291331008366 putative allosteric switch controlling residues; other site 291331008367 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 291331008368 osmolarity response regulator; Provisional; Region: ompR; PRK09468 291331008369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331008370 active site 291331008371 phosphorylation site [posttranslational modification] 291331008372 intermolecular recognition site; other site 291331008373 dimerization interface [polypeptide binding]; other site 291331008374 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331008375 DNA binding site [nucleotide binding] 291331008376 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 291331008377 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 291331008378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331008379 dimer interface [polypeptide binding]; other site 291331008380 phosphorylation site [posttranslational modification] 291331008381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331008382 ATP binding site [chemical binding]; other site 291331008383 Mg2+ binding site [ion binding]; other site 291331008384 G-X-G motif; other site 291331008385 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 291331008386 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331008387 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 291331008388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331008389 ATP binding site [chemical binding]; other site 291331008390 Mg2+ binding site [ion binding]; other site 291331008391 G-X-G motif; other site 291331008392 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 291331008393 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 291331008394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008396 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 291331008397 G1 box; other site 291331008398 GTP/Mg2+ binding site [chemical binding]; other site 291331008399 Switch I region; other site 291331008400 G2 box; other site 291331008401 G3 box; other site 291331008402 Switch II region; other site 291331008403 G4 box; other site 291331008404 G5 box; other site 291331008405 Cytochrome c; Region: Cytochrom_C; cl11414 291331008406 Cytochrome c; Region: Cytochrom_C; cl11414 291331008407 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 291331008408 catalytic residues [active] 291331008409 hinge region; other site 291331008410 alpha helical domain; other site 291331008411 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 291331008412 putative catalytic site [active] 291331008413 putative metal binding site [ion binding]; other site 291331008414 putative phosphate binding site [ion binding]; other site 291331008415 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 291331008416 putative catalytic site [active] 291331008417 putative phosphate binding site [ion binding]; other site 291331008418 putative metal binding site [ion binding]; other site 291331008419 Integrase core domain; Region: rve; cl01316 291331008420 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331008421 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331008422 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331008423 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 291331008424 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291331008425 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331008426 catalytic residue [active] 291331008427 Transposase domain (DUF772); Region: DUF772; cl12084 291331008428 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331008429 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331008430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008431 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331008432 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 291331008433 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 291331008434 active site 291331008435 NTP binding site [chemical binding]; other site 291331008436 metal binding triad [ion binding]; metal-binding site 291331008437 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 291331008439 Transposase domain (DUF772); Region: DUF772; cl12084 291331008440 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331008441 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331008442 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331008443 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331008444 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 291331008445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331008446 binding surface 291331008447 TPR motif; other site 291331008448 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 291331008449 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 291331008450 N-glycosyltransferase; Provisional; Region: PRK11204 291331008451 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 291331008452 DXD motif; other site 291331008453 hemin storage system protein; Provisional; Region: hmsS; cl14676 291331008454 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 291331008455 active site 291331008456 dimer interface [polypeptide binding]; other site 291331008457 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 291331008458 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 291331008459 dimer interface [polypeptide binding]; other site 291331008460 active site 291331008461 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 291331008462 dimer interface [polypeptide binding]; other site 291331008463 active site 291331008464 Transcriptional regulators [Transcription]; Region: PurR; COG1609 291331008465 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 291331008466 DNA binding site [nucleotide binding] 291331008467 domain linker motif; other site 291331008468 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 291331008469 putative dimerization interface [polypeptide binding]; other site 291331008470 putative ligand binding site [chemical binding]; other site 291331008471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 291331008472 glucose/galactose transporter; Region: gluP; TIGR01272 291331008473 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 291331008474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 291331008475 DNA-binding site [nucleotide binding]; DNA binding site 291331008476 UTRA domain; Region: UTRA; cl06649 291331008477 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 291331008478 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 291331008479 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 291331008480 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 291331008481 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 291331008482 domain; Region: Glyco_hydro_2; pfam00703 291331008483 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 291331008484 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331008485 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331008486 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331008487 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331008488 Integrase core domain; Region: rve; cl01316 291331008489 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331008490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331008491 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331008492 Uncharacterized conserved protein [Function unknown]; Region: COG1565 291331008493 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 291331008494 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 291331008495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331008496 NAD(P) binding site [chemical binding]; other site 291331008497 active site 291331008498 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 291331008499 catalytic center binding site [active] 291331008500 ATP binding site [chemical binding]; other site 291331008501 Response regulator receiver domain; Region: Response_reg; pfam00072 291331008502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331008503 active site 291331008504 phosphorylation site [posttranslational modification] 291331008505 intermolecular recognition site; other site 291331008506 dimerization interface [polypeptide binding]; other site 291331008507 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 291331008508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331008509 ATP binding site [chemical binding]; other site 291331008510 Mg2+ binding site [ion binding]; other site 291331008511 G-X-G motif; other site 291331008512 Response regulator receiver domain; Region: Response_reg; pfam00072 291331008513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331008514 active site 291331008515 phosphorylation site [posttranslational modification] 291331008516 intermolecular recognition site; other site 291331008517 dimerization interface [polypeptide binding]; other site 291331008518 CHASE3 domain; Region: CHASE3; cl05000 291331008519 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 291331008520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331008521 dimer interface [polypeptide binding]; other site 291331008522 phosphorylation site [posttranslational modification] 291331008523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331008524 ATP binding site [chemical binding]; other site 291331008525 Mg2+ binding site [ion binding]; other site 291331008526 G-X-G motif; other site 291331008527 BON domain; Region: BON; cl02771 291331008528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331008529 putative oxidoreductase; Provisional; Region: PRK11579 291331008530 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 291331008531 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 291331008532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331008533 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 291331008534 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 291331008535 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general...; Region: PBEF_like; cd01569 291331008536 active site 291331008537 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 291331008538 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 291331008539 active site 291331008540 (T/H)XGH motif; other site 291331008541 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 291331008542 nudix motif; other site 291331008543 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 291331008544 putative catalytic site [active] 291331008545 putative metal binding site [ion binding]; other site 291331008546 putative phosphate binding site [ion binding]; other site 291331008547 carboxy-terminal protease; Provisional; Region: PRK11186 291331008548 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 291331008549 protein binding site [polypeptide binding]; other site 291331008550 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 291331008551 Catalytic dyad [active] 291331008552 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 291331008553 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 291331008554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331008555 lipoyl synthase; Provisional; Region: PRK05481 291331008556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 291331008557 FeS/SAM binding site; other site 291331008558 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 291331008559 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 291331008560 Beta-lactamase; Region: Beta-lactamase; cl01009 291331008561 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 291331008562 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 291331008563 Sporulation related domain; Region: SPOR; cl10051 291331008564 lytic murein transglycosylase; Region: MltB_2; TIGR02283 291331008565 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 291331008566 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 291331008567 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 291331008568 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331008569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 291331008570 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 291331008571 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 291331008572 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 291331008573 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 291331008574 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 291331008575 rod shape-determining protein MreD; Region: MreD; cl01087 291331008576 rod shape-determining protein MreB; Provisional; Region: PRK13927 291331008577 Cell division protein FtsA; Region: FtsA; cl11496 291331008578 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 291331008579 substrate binding site [chemical binding]; other site 291331008580 ATP binding site [chemical binding]; other site 291331008582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008583 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331008584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 291331008586 motif II; other site 291331008587 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 291331008588 nucleoside/Zn binding site; other site 291331008589 dimer interface [polypeptide binding]; other site 291331008590 catalytic motif [active] 291331008591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331008592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331008593 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 291331008594 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 291331008595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331008596 S-adenosylmethionine binding site [chemical binding]; other site 291331008597 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331008598 metal binding site [ion binding]; metal-binding site 291331008599 active site 291331008600 I-site; other site 291331008601 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 291331008602 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 291331008603 active site 291331008604 Zn binding site [ion binding]; other site 291331008605 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 291331008606 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 291331008607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 291331008608 active site 291331008609 motif I; other site 291331008610 motif II; other site 291331008611 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 291331008612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331008613 Walker A motif; other site 291331008614 ATP binding site [chemical binding]; other site 291331008615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331008616 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 291331008617 active site 291331008618 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 291331008619 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 291331008620 DNA binding site [nucleotide binding] 291331008621 Int/Topo IB signature motif; other site 291331008622 active site 291331008623 Protein of unknown function, DUF484; Region: DUF484; cl01228 291331008624 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 291331008625 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 291331008626 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 291331008627 Protein of unknown function (DUF454); Region: DUF454; cl01063 291331008628 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 291331008629 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331008630 aspartate aminotransferase; Provisional; Region: PRK08361 291331008631 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 291331008632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 291331008633 homodimer interface [polypeptide binding]; other site 291331008634 catalytic residue [active] 291331008635 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 291331008636 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331008637 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 291331008638 Predicted transcriptional regulator [Transcription]; Region: COG2378 291331008639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331008640 Protein of unknown function, DUF481; Region: DUF481; cl01213 291331008641 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 291331008642 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 291331008643 domain interfaces; other site 291331008644 active site 291331008645 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 291331008646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331008647 active site 291331008648 phosphorylation site [posttranslational modification] 291331008649 intermolecular recognition site; other site 291331008650 dimerization interface [polypeptide binding]; other site 291331008651 LytTr DNA-binding domain; Region: LytTR; cl04498 291331008652 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 291331008653 Histidine kinase; Region: His_kinase; pfam06580 291331008654 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 291331008655 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331008656 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 291331008657 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 291331008658 Ligand binding site [chemical binding]; other site 291331008659 DXD motif; other site 291331008660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008661 M28, and M42; Region: Zinc_peptidase_like; cl14876 291331008662 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-...; Region: PA_M28_1_2; cd04821 291331008663 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 291331008664 PA/protease or protease-like domain interface [polypeptide binding]; other site 291331008665 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 291331008666 metal binding site [ion binding]; metal-binding site 291331008667 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 291331008668 Sulfate transporter family; Region: Sulfate_transp; cl00967 291331008669 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 291331008670 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 291331008671 Cellulose binding domain; Region: CBM_2; cl02709 291331008672 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 291331008673 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 291331008674 GAF domain; Region: GAF; cl00853 291331008675 PAS fold; Region: PAS; pfam00989 291331008676 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 291331008677 PAS domain S-box; Region: sensory_box; TIGR00229 291331008678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 291331008679 putative active site [active] 291331008680 heme pocket [chemical binding]; other site 291331008681 PAS domain S-box; Region: sensory_box; TIGR00229 291331008682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 291331008683 putative active site [active] 291331008684 heme pocket [chemical binding]; other site 291331008685 PAS fold; Region: PAS_4; pfam08448 291331008686 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 291331008687 metal binding site [ion binding]; metal-binding site 291331008688 active site 291331008689 I-site; other site 291331008690 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 291331008691 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 291331008692 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 291331008693 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 291331008694 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 291331008695 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 291331008696 GAF domain; Region: GAF; cl00853 291331008697 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008698 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 291331008699 DNA binding site [nucleotide binding] 291331008700 Protein of unknown function DUF72; Region: DUF72; cl00777 291331008701 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 291331008702 Protein of unknown function DUF124; Region: DUF124; cl00884 291331008703 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 291331008704 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 291331008705 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 291331008706 Amino acid permease; Region: AA_permease; pfam00324 291331008707 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 291331008708 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 291331008709 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 291331008710 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 291331008711 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 291331008712 Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521 291331008713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331008714 S-adenosylmethionine binding site [chemical binding]; other site 291331008716 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 291331008717 GAD-like domain; Region: GAD-like; pfam08887 291331008718 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 291331008719 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331008720 substrate binding pocket [chemical binding]; other site 291331008721 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 291331008722 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 291331008723 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331008724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331008725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331008726 active site 291331008727 Integrase core domain; Region: rve; cl01316 291331008728 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331008729 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291331008730 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 291331008731 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331008732 catalytic residue [active] 291331008733 anthranilate synthase component I; Provisional; Region: PRK13565 291331008734 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 291331008735 chorismate binding enzyme; Region: Chorismate_bind; cl10555 291331008736 lipid kinase; Reviewed; Region: PRK13054 291331008737 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 291331008738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 291331008739 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 291331008740 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 291331008741 substrate binding site [chemical binding]; other site 291331008742 hexamer interface [polypeptide binding]; other site 291331008743 metal binding site [ion binding]; metal-binding site 291331008744 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 291331008745 HSP70 interaction site [polypeptide binding]; other site 291331008746 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 291331008747 ATP binding site [chemical binding]; other site 291331008748 active site 291331008749 substrate binding site [chemical binding]; other site 291331008750 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331008751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331008754 Integrase core domain; Region: rve; cl01316 291331008755 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 291331008756 putative metal binding site [ion binding]; other site 291331008757 Protein of unknown function (DUF962); Region: DUF962; cl01879 291331008758 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 291331008759 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 291331008760 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 291331008761 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 291331008762 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 291331008763 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 291331008764 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 291331008765 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 291331008766 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 291331008767 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 291331008768 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 291331008769 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 291331008770 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 291331008771 dimer interface [polypeptide binding]; other site 291331008772 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 291331008773 active site 291331008774 Fe binding site [ion binding]; other site 291331008775 Transcriptional regulators [Transcription]; Region: MarR; COG1846 291331008776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331008777 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 291331008778 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 291331008779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 291331008780 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 291331008781 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 291331008782 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 291331008783 tetramer interface [polypeptide binding]; other site 291331008784 TPP-binding site [chemical binding]; other site 291331008785 heterodimer interface [polypeptide binding]; other site 291331008786 phosphorylation loop region [posttranslational modification] 291331008787 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 291331008788 alpha subunit interface [polypeptide binding]; other site 291331008789 TPP binding site [chemical binding]; other site 291331008790 heterodimer interface [polypeptide binding]; other site 291331008791 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331008792 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331008793 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 291331008794 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 291331008795 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization...; Region: SH3; cl09950 291331008796 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization...; Region: SH3; cl09950 291331008797 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 291331008798 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 291331008799 dimer interface [polypeptide binding]; other site 291331008800 active site 291331008801 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 291331008802 HemY protein N-terminus; Region: HemY_N; pfam07219 291331008803 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 291331008804 active site 291331008805 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 291331008806 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 291331008807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008809 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 291331008810 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 291331008811 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 291331008812 Ca2+ binding site [ion binding]; other site 291331008813 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cl09501 291331008814 Ca2+ binding site [ion binding]; other site 291331008815 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 291331008816 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 291331008817 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 291331008818 amidase catalytic site [active] 291331008819 Zn binding residues [ion binding]; other site 291331008820 substrate binding site [chemical binding]; other site 291331008821 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 291331008822 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 291331008823 NlpC/P60 family; Region: NLPC_P60; cl11438 291331008824 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 291331008825 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 291331008826 active site 291331008827 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331008828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008829 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008830 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 291331008831 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331008832 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331008833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 291331008835 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 291331008836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008837 hypothetical protein; Provisional; Region: PRK11383 291331008838 yiaA/B two helix domain; Region: YiaAB; cl01759 291331008839 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 291331008840 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 291331008841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331008842 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331008843 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331008844 Integrase core domain; Region: rve; cl01316 291331008845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008846 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331008847 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331008848 Integrase core domain; Region: rve; cl01316 291331008849 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 291331008850 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 291331008851 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 291331008852 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 291331008853 homooctamer interface [polypeptide binding]; other site 291331008854 active site 291331008855 UGMP family protein; Validated; Region: PRK09604 291331008856 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 291331008857 GatB domain; Region: GatB_Yqey; cl11497 291331008858 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 291331008859 DNA primase; Validated; Region: dnaG; PRK05667 291331008860 CHC2 zinc finger; Region: zf-CHC2; cl02597 291331008861 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 291331008862 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 291331008863 active site 291331008864 metal binding site [ion binding]; metal-binding site 291331008865 interdomain interaction site; other site 291331008866 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 291331008867 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 291331008868 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331008869 Membrane transport protein; Region: Mem_trans; cl09117 291331008870 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 291331008871 catalytic residues [active] 291331008872 UbiA prenyltransferase family; Region: UbiA; cl00337 291331008873 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 291331008874 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 291331008875 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 291331008876 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 291331008877 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 291331008878 Subunit III/VIIa interface [polypeptide binding]; other site 291331008879 Phospholipid binding site [chemical binding]; other site 291331008880 Subunit I/III interface [polypeptide binding]; other site 291331008881 Subunit III/VIb interface [polypeptide binding]; other site 291331008882 Subunit III/VIa interface; other site 291331008883 Subunit III/Vb interface [polypeptide binding]; other site 291331008884 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 291331008885 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 291331008886 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 291331008887 Subunit I/III interface [polypeptide binding]; other site 291331008888 D-pathway; other site 291331008889 Subunit I/VIIc interface [polypeptide binding]; other site 291331008890 Subunit I/IV interface [polypeptide binding]; other site 291331008891 Subunit I/II interface [polypeptide binding]; other site 291331008892 Low-spin heme (heme a) binding site [chemical binding]; other site 291331008893 Subunit I/VIIa interface [polypeptide binding]; other site 291331008894 Subunit I/VIa interface [polypeptide binding]; other site 291331008895 Dimer interface; other site 291331008896 Putative water exit pathway; other site 291331008897 Binuclear center (heme a3/CuB) [ion binding]; other site 291331008898 K-pathway; other site 291331008899 Subunit I/Vb interface [polypeptide binding]; other site 291331008900 Putative proton exit pathway; other site 291331008901 Subunit I/VIb interface; other site 291331008902 Subunit I/VIc interface [polypeptide binding]; other site 291331008903 Electron transfer pathway; other site 291331008904 Subunit I/VIIIb interface [polypeptide binding]; other site 291331008905 Subunit I/VIIb interface [polypeptide binding]; other site 291331008906 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 291331008907 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 291331008908 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 291331008909 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 291331008910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008911 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 291331008912 Proline dehydrogenase; Region: Pro_dh; cl03282 291331008913 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 291331008914 Glutamate binding site [chemical binding]; other site 291331008915 NAD binding site [chemical binding]; other site 291331008916 catalytic residues [active] 291331008917 Integrase core domain; Region: rve; cl01316 291331008918 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331008919 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331008920 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 291331008921 Ferritin-like domain; Region: Ferritin; pfam00210 291331008922 heme binding site [chemical binding]; other site 291331008923 ferroxidase pore; other site 291331008924 ferroxidase diiron center [ion binding]; other site 291331008925 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 291331008926 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 291331008927 putative active site [active] 291331008928 Ap4A binding site [chemical binding]; other site 291331008929 nudix motif; other site 291331008930 putative metal binding site [ion binding]; other site 291331008931 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 291331008932 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 291331008933 23S rRNA interface [nucleotide binding]; other site 291331008934 L3 interface [polypeptide binding]; other site 291331008935 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 291331008936 diiron binding motif [ion binding]; other site 291331008937 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 291331008938 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 291331008939 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 291331008940 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 291331008941 ligand binding site [chemical binding]; other site 291331008942 flexible hinge region; other site 291331008943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331008944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 291331008945 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 291331008946 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 291331008947 active site 291331008948 ribulose/triose binding site [chemical binding]; other site 291331008949 phosphate binding site [ion binding]; other site 291331008950 substrate (anthranilate) binding pocket [chemical binding]; other site 291331008951 product (indole) binding pocket [chemical binding]; other site 291331008952 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 291331008953 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 291331008954 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 291331008955 Flavin Reductases; Region: FlaRed; cl00801 291331008956 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 291331008957 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 291331008958 glutamine binding [chemical binding]; other site 291331008959 catalytic triad [active] 291331008960 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 291331008961 putative transposase OrfB; Reviewed; Region: PHA02517 291331008962 Integrase core domain; Region: rve; cl01316 291331008963 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331008964 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 291331008965 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 291331008966 Uncharacterized conserved protein [Function unknown]; Region: COG4715 291331008967 Uncharacterized conserved protein [Function unknown]; Region: COG4715 291331008968 Transposase domain (DUF772); Region: DUF772; cl12084 291331008969 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331008970 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331008971 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331008972 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331008973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008974 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331008975 Transposase domain (DUF772); Region: DUF772; cl12084 291331008976 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331008977 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331008978 Integrase core domain; Region: rve; cl01316 291331008979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 291331008980 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 291331008981 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 291331008982 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331008983 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008984 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 291331008985 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 291331008986 metal binding site [ion binding]; metal-binding site 291331008987 putative dimer interface [polypeptide binding]; other site 291331008988 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 291331008989 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 291331008990 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 291331008991 Protein export membrane protein; Region: SecD_SecF; cl14618 291331008992 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 291331008993 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 291331008994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331008995 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331008996 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331008997 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 291331008998 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 291331008999 active site residue [active] 291331009000 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 291331009001 SecA binding site; other site 291331009002 Preprotein binding site; other site 291331009003 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 291331009004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331009005 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 291331009006 pyruvate dehydrogenase; Provisional; Region: PRK09124 291331009007 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 291331009008 PYR/PP interface [polypeptide binding]; other site 291331009009 tetramer interface [polypeptide binding]; other site 291331009010 dimer interface [polypeptide binding]; other site 291331009011 TPP binding site [chemical binding]; other site 291331009012 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 291331009013 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 291331009014 TPP-binding site [chemical binding]; other site 291331009015 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 291331009016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 291331009017 dimer interface [polypeptide binding]; other site 291331009018 phosphorylation site [posttranslational modification] 291331009019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331009020 ATP binding site [chemical binding]; other site 291331009021 Mg2+ binding site [ion binding]; other site 291331009022 G-X-G motif; other site 291331009023 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 291331009024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331009025 active site 291331009026 phosphorylation site [posttranslational modification] 291331009027 intermolecular recognition site; other site 291331009028 dimerization interface [polypeptide binding]; other site 291331009029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331009030 Walker A motif; other site 291331009031 ATP binding site [chemical binding]; other site 291331009032 Walker B motif; other site 291331009033 arginine finger; other site 291331009034 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 291331009035 conjugal transfer protein TrbE; Provisional; Region: PRK13891 291331009036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331009037 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 291331009038 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 291331009039 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 291331009040 dimer interface [polypeptide binding]; other site 291331009041 active site 291331009042 CoA binding pocket [chemical binding]; other site 291331009043 Fic family protein [Function unknown]; Region: COG3177 291331009044 Fic/DOC family; Region: Fic; cl00960 291331009045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331009046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331009047 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 291331009048 haloalkane dehalogenase; Provisional; Region: PRK03592 291331009049 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331009050 Flagellin N-methylase; Region: FliB; cl00497 291331009051 peptide synthase; Provisional; Region: PRK09274 291331009052 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 291331009053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331009054 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 291331009055 NAD(P) binding site [chemical binding]; other site 291331009056 active site 291331009057 Transposase domain (DUF772); Region: DUF772; cl12084 291331009058 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 291331009059 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 291331009060 Zn2+ binding site [ion binding]; other site 291331009061 Mg2+ binding site [ion binding]; other site 291331009062 benzoate transport; Region: 2A0115; TIGR00895 291331009063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331009064 putative substrate translocation pore; other site 291331009065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331009066 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331009067 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331009068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331009069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331009070 Integrase core domain; Region: rve; cl01316 291331009071 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 291331009072 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 291331009073 trimer interface [polypeptide binding]; other site 291331009074 putative metal binding site [ion binding]; other site 291331009076 Dehydratase family; Region: ILVD_EDD; cl00340 291331009077 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 291331009078 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 291331009079 Phage integrase family; Region: Phage_integrase; pfam00589 291331009080 DNA binding site [nucleotide binding] 291331009081 Int/Topo IB signature motif; other site 291331009082 active site 291331009083 Transposase domain (DUF772); Region: DUF772; cl12084 291331009084 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 291331009085 DNA polymerase I; Provisional; Region: PRK05755 291331009086 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 291331009087 active site 291331009088 metal binding site 1 [ion binding]; metal-binding site 291331009089 putative 5' ssDNA interaction site; other site 291331009090 metal binding site 3; metal-binding site 291331009091 metal binding site 2 [ion binding]; metal-binding site 291331009092 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 291331009093 putative DNA binding site [nucleotide binding]; other site 291331009094 putative metal binding site [ion binding]; other site 291331009095 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 291331009096 active site 291331009097 catalytic site [active] 291331009098 substrate binding site [chemical binding]; other site 291331009099 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 291331009100 active site 291331009101 DNA binding site [nucleotide binding] 291331009102 catalytic site [active] 291331009103 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 291331009104 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 291331009105 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 291331009106 Jacalin-like lectin domain; Region: Jacalin_like; cl03205 291331009107 putative sugar binding site [chemical binding]; other site 291331009108 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331009109 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331009110 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 291331009111 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 291331009113 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 291331009114 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 291331009115 nucleophilic elbow; other site 291331009116 catalytic triad; other site 291331009117 Transposase domain (DUF772); Region: DUF772; cl12084 291331009118 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 291331009119 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331009120 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 291331009121 Transposase domain (DUF772); Region: DUF772; cl12084 291331009122 putative transposase OrfB; Reviewed; Region: PHA02517 291331009123 Cache domain; Region: Cache_1; pfam02743 291331009124 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 291331009125 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 291331009126 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 291331009127 anti sigma factor interaction site; other site 291331009128 regulatory phosphorylation site [posttranslational modification]; other site 291331009129 YceI-like domain; Region: YceI; cl01001 291331009130 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 291331009131 putative FMN binding site [chemical binding]; other site 291331009132 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 291331009133 Protein of unknown function (DUF1022); Region: DUF1022; pfam06258 291331009134 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 291331009135 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 291331009136 active site 291331009137 catalytic residues [active] 291331009138 Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; pfam09286 291331009139 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 291331009140 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 291331009141 metal binding triad; other site 291331009142 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 291331009143 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 291331009144 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 291331009145 metal binding triad; other site 291331009146 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 291331009147 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331009148 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331009149 NeuB family; Region: NeuB; cl00496 291331009150 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 291331009151 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331009152 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331009153 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 291331009154 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 291331009155 ring oligomerisation interface [polypeptide binding]; other site 291331009156 ATP/Mg binding site [chemical binding]; other site 291331009157 stacking interactions; other site 291331009158 hinge regions; other site 291331009159 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 291331009160 oligomerisation interface [polypeptide binding]; other site 291331009161 mobile loop; other site 291331009162 roof hairpin; other site 291331009163 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 291331009164 putative metal binding site [ion binding]; other site 291331009165 LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7; Region: LOTUS; cl14879 291331009166 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 291331009167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331009168 UPF0126 domain; Region: UPF0126; pfam03458 291331009169 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 291331009170 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 291331009171 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 291331009172 DNA binding residues [nucleotide binding] 291331009173 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 291331009174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331009175 active site 291331009176 phosphorylation site [posttranslational modification] 291331009177 intermolecular recognition site; other site 291331009178 dimerization interface [polypeptide binding]; other site 291331009179 Response regulator receiver domain; Region: Response_reg; pfam00072 291331009180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331009181 active site 291331009182 phosphorylation site [posttranslational modification] 291331009183 intermolecular recognition site; other site 291331009184 dimerization interface [polypeptide binding]; other site 291331009185 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 291331009186 FtsX-like permease family; Region: FtsX; pfam02687 291331009187 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 291331009188 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331009189 Walker A/P-loop; other site 291331009190 ATP binding site [chemical binding]; other site 291331009191 Q-loop/lid; other site 291331009192 ABC transporter signature motif; other site 291331009193 Walker B; other site 291331009194 D-loop; other site 291331009195 H-loop/switch region; other site 291331009196 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04537 291331009197 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 291331009198 ATP binding site [chemical binding]; other site 291331009199 Mg++ binding site [ion binding]; other site 291331009200 motif III; other site 291331009201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331009202 nucleotide binding region [chemical binding]; other site 291331009203 ATP-binding site [chemical binding]; other site 291331009204 Protein of unknown function (DUF3628); Region: DUF3628; pfam12300 291331009205 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 291331009206 catalytic residues [active] 291331009207 transcription termination factor Rho; Provisional; Region: rho; PRK09376 291331009208 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 291331009209 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 291331009210 RNA binding site [nucleotide binding]; other site 291331009211 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 291331009212 multimer interface [polypeptide binding]; other site 291331009213 Walker A motif; other site 291331009214 ATP binding site [chemical binding]; other site 291331009215 Walker B motif; other site 291331009216 putative transposase OrfB; Reviewed; Region: PHA02517 291331009217 Integrase core domain; Region: rve; cl01316 291331009218 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 291331009219 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 291331009220 Surface antigen; Region: Bac_surface_Ag; cl03097 291331009221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 291331009222 Family of unknown function (DUF490); Region: DUF490; pfam04357 291331009223 Family of unknown function (DUF490); Region: DUF490; pfam04357 291331009224 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 291331009225 putative active site 1 [active] 291331009227 Predicted acyltransferase [General function prediction only]; Region: COG4261 291331009228 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 291331009229 putative acyl-acceptor binding pocket; other site 291331009230 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 291331009231 Phosphopantetheine attachment site; Region: PP-binding; cl09936 291331009232 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 291331009233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 291331009234 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 291331009235 homotrimer interaction site [polypeptide binding]; other site 291331009236 putative active site [active] 291331009237 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 291331009238 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 291331009239 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 291331009240 translocation protein TolB; Provisional; Region: tolB; PRK04922 291331009241 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 291331009242 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331009243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331009244 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 291331009245 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 291331009246 NADP binding site [chemical binding]; other site 291331009247 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 291331009248 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 291331009249 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Provisional; Region: PRK08575 291331009250 substrate binding site [chemical binding]; other site 291331009251 THF binding site; other site 291331009252 zinc-binding site [ion binding]; other site 291331009253 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 291331009254 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 291331009255 Transcriptional regulator [Transcription]; Region: LysR; COG0583 291331009256 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331009257 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 291331009258 putative dimerization interface [polypeptide binding]; other site 291331009259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 291331009260 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 291331009261 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 291331009262 FAD binding site [chemical binding]; other site 291331009263 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 291331009264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331009265 active site 291331009266 phosphorylation site [posttranslational modification] 291331009267 intermolecular recognition site; other site 291331009268 dimerization interface [polypeptide binding]; other site 291331009269 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 291331009270 DNA binding site [nucleotide binding] 291331009271 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 291331009272 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 291331009273 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 291331009274 putative substrate binding site [chemical binding]; other site 291331009275 putative active site [active] 291331009276 putative cosubstrate binding site; other site 291331009277 catalytic site [active] 291331009278 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 291331009279 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331009280 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 291331009281 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 291331009282 active site 291331009283 FMN binding site [chemical binding]; other site 291331009284 substrate binding site [chemical binding]; other site 291331009285 homotetramer interface [polypeptide binding]; other site 291331009286 catalytic residue [active] 291331009287 NAD-dependent deacetylase; Provisional; Region: PRK05333 291331009288 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/...; Region: SIRT4; cd01409 291331009289 NAD+ binding site [chemical binding]; other site 291331009290 substrate binding site [chemical binding]; other site 291331009291 Zn binding site [ion binding]; other site 291331009292 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 291331009293 DNA binding residues [nucleotide binding] 291331009294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331009295 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 291331009296 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331009297 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 291331009298 putative dimerization interface [polypeptide binding]; other site 291331009299 putative substrate binding pocket [chemical binding]; other site 291331009300 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 291331009301 active site 291331009302 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 291331009303 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 291331009304 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331009305 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 291331009306 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331009307 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331009308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331009309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 291331009310 Integrase core domain; Region: rve; cl01316 291331009312 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291331009313 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331009314 catalytic residue [active] 291331009315 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 291331009316 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 291331009317 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331009318 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331009319 Integrase core domain; Region: rve; cl01316 291331009320 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331009321 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331009322 Integrase core domain; Region: rve; cl01316 291331009323 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 291331009324 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 291331009325 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 291331009326 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 291331009327 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 291331009328 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 291331009329 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 291331009330 carboxyltransferase (CT) interaction site; other site 291331009331 biotinylation site [posttranslational modification]; other site 291331009332 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 291331009333 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 291331009334 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 291331009335 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 291331009336 isovaleryl-CoA dehydrogenase; Region: PLN02519 291331009337 substrate binding site [chemical binding]; other site 291331009338 FAD binding site [chemical binding]; other site 291331009339 catalytic base [active] 291331009340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 291331009341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 291331009342 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 291331009343 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 291331009344 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 291331009345 Cytochrome c; Region: Cytochrom_C; cl11414 291331009346 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 291331009347 generic binding surface I; other site 291331009348 generic binding surface II; other site 291331009349 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 291331009350 putative catalytic site [active] 291331009351 putative metal binding site [ion binding]; other site 291331009352 putative phosphate binding site [ion binding]; other site 291331009353 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 291331009354 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 291331009355 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 291331009356 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 291331009357 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 291331009358 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 291331009359 Predicted ATPase [General function prediction only]; Region: COG1485 291331009360 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331009361 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331009362 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 291331009363 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 291331009364 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 291331009365 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 291331009366 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 291331009367 dimer interface [polypeptide binding]; other site 291331009368 motif 1; other site 291331009369 active site 291331009370 motif 2; other site 291331009371 motif 3; other site 291331009372 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 291331009373 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 291331009374 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 291331009375 Walker A motif; other site 291331009376 ATP binding site [chemical binding]; other site 291331009377 Walker B motif; other site 291331009378 hypothetical protein; Provisional; Region: PRK14707 291331009379 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 291331009380 synthetase active site [active] 291331009381 NTP binding site [chemical binding]; other site 291331009382 metal binding site [ion binding]; metal-binding site 291331009383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331009384 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331009385 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331009386 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 291331009387 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 291331009388 catalytic triad [active] 291331009389 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 291331009390 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 291331009391 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 291331009392 Family of unknown function (DUF500); Region: DUF500; cl01109 291331009393 ferrochelatase; Reviewed; Region: hemH; PRK00035 291331009394 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 291331009395 C-terminal domain interface [polypeptide binding]; other site 291331009396 active site 291331009397 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 291331009398 active site 291331009399 N-terminal domain interface [polypeptide binding]; other site 291331009400 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 291331009401 Protein of unknown function DUF45; Region: DUF45; cl00636 291331009402 Putative exonuclease, RdgC; Region: RdgC; cl01122 291331009403 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 291331009404 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 291331009405 Ligand Binding Site [chemical binding]; other site 291331009406 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 291331009407 xylose isomerase; Region: PLN02923 291331009408 Transcriptional regulators [Transcription]; Region: PurR; COG1609 291331009409 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 291331009410 DNA binding site [nucleotide binding] 291331009411 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 291331009412 putative dimerization interface [polypeptide binding]; other site 291331009413 putative ligand binding site [chemical binding]; other site 291331009414 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 291331009415 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 291331009416 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 291331009417 Domain of unknown function (DUF303); Region: DUF303; pfam03629 291331009418 Domain of unknown function (DUF303); Region: DUF303; pfam03629 291331009419 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 291331009420 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 291331009421 putative active site pocket [active] 291331009422 putative metal binding site [ion binding]; other site 291331009423 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 291331009424 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 291331009425 inhibitor binding site; inhibition site 291331009426 active site 291331009427 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 291331009428 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 291331009429 PA14 domain; Region: PA14; cl08459 291331009430 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 291331009431 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 291331009432 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 291331009433 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 291331009434 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 291331009435 metal binding site [ion binding]; metal-binding site 291331009436 Glucuronate isomerase; Region: UxaC; cl00829 291331009437 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 291331009438 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 291331009439 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 291331009440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331009441 D-galactonate transporter; Region: 2A0114; TIGR00893 291331009442 putative substrate translocation pore; other site 291331009443 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 291331009444 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331009445 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 291331009446 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 291331009447 putative transporter; Provisional; Region: PRK11462 291331009448 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 291331009449 substrate binding site [chemical binding]; other site 291331009450 active site 291331009451 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331009452 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331009453 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331009454 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331009455 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 291331009456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331009457 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 291331009458 Fatty acid desaturase; Region: FA_desaturase; pfam00487 291331009459 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 291331009460 putative di-iron ligands [ion binding]; other site 291331009461 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 291331009462 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 291331009463 FAD binding pocket [chemical binding]; other site 291331009464 FAD binding motif [chemical binding]; other site 291331009465 phosphate binding motif [ion binding]; other site 291331009466 beta-alpha-beta structure motif; other site 291331009467 NAD binding pocket [chemical binding]; other site 291331009468 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 291331009469 catalytic loop [active] 291331009470 iron binding site [ion binding]; other site 291331009471 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 291331009472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 291331009473 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331009474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331009475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331009476 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331009477 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 291331009478 Integrase core domain; Region: rve; cl01316 291331009479 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 291331009480 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 291331009481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331009482 OsmC-like protein; Region: OsmC; cl00767 291331009483 Protein of unknown function (DUF2884); Region: DUF2884; cl08135 291331009484 Transposase domain (DUF772); Region: DUF772; cl12084 291331009485 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331009486 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 291331009487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 291331009488 Uncharacterized conserved protein [Function unknown]; Region: COG4104 291331009489 PAAR motif; Region: PAAR_motif; pfam05488 291331009490 DUF based on B. Theta Gene description; Region: DUF3876; pfam12992 291331009491 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 291331009492 active site 291331009493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 291331009494 non-specific DNA binding site [nucleotide binding]; other site 291331009495 salt bridge; other site 291331009496 sequence-specific DNA binding site [nucleotide binding]; other site 291331009497 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 291331009498 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 291331009499 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 291331009500 UvrD/REP helicase; Region: UvrD-helicase; cl14126 291331009501 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 291331009502 UvrD/REP helicase; Region: UvrD-helicase; cl14126 291331009503 UvrD/REP helicase; Region: UvrD-helicase; cl14126 291331009504 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 291331009505 UvrD/REP helicase; Region: UvrD-helicase; cl14126 291331009506 UvrD/REP helicase; Region: UvrD-helicase; cl14126 291331009507 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 291331009508 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 291331009509 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 291331009510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331009511 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 291331009512 Walker A/P-loop; other site 291331009513 ATP binding site [chemical binding]; other site 291331009514 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 291331009515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331009516 ABC transporter signature motif; other site 291331009517 Walker B; other site 291331009518 D-loop; other site 291331009519 H-loop/switch region; other site 291331009520 Putative Ig domain; Region: He_PIG; cl09256 291331009521 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 291331009522 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 291331009523 Phage Tail Collar Domain; Region: Collar; pfam07484 291331009524 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 291331009525 Phage Tail Collar Domain; Region: Collar; pfam07484 291331009526 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331009527 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331009528 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 291331009529 E-class dimer interface [polypeptide binding]; other site 291331009530 P-class dimer interface [polypeptide binding]; other site 291331009531 active site 291331009532 Cu2+ binding site [ion binding]; other site 291331009533 Zn2+ binding site [ion binding]; other site 291331009534 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 291331009535 P-class dimer interface [polypeptide binding]; other site 291331009536 active site 291331009537 Cu2+ binding site [ion binding]; other site 291331009538 E-class dimer interface [polypeptide binding]; other site 291331009539 Zn2+ binding site [ion binding]; other site 291331009540 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 291331009541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331009542 active site 291331009543 phosphorylation site [posttranslational modification] 291331009544 intermolecular recognition site; other site 291331009545 dimerization interface [polypeptide binding]; other site 291331009546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 291331009547 Walker A motif; other site 291331009548 ATP binding site [chemical binding]; other site 291331009549 Walker B motif; other site 291331009550 arginine finger; other site 291331009551 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 291331009552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 291331009553 ATP binding site [chemical binding]; other site 291331009554 Mg2+ binding site [ion binding]; other site 291331009555 G-X-G motif; other site 291331009556 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 291331009557 Nitrogen regulatory protein P-II; Region: P-II; cl00412 291331009558 glutamine synthetase; Provisional; Region: glnA; PRK09469 291331009559 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 291331009560 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 291331009561 Bacitracin resistance protein BacA; Region: BacA; cl00858 291331009562 META domain; Region: META; cl01245 291331009564 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 291331009565 substrate binding site [chemical binding]; other site 291331009566 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 291331009567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331009568 TPR motif; other site 291331009569 binding surface 291331009570 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331009571 binding surface 291331009572 TPR motif; other site 291331009573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331009574 binding surface 291331009575 TPR motif; other site 291331009576 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 291331009577 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 291331009578 putative acyl-acceptor binding pocket; other site 291331009579 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 291331009580 CoenzymeA binding site [chemical binding]; other site 291331009581 subunit interaction site [polypeptide binding]; other site 291331009582 PHB binding site; other site 291331009583 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 291331009584 putative active site [active] 291331009585 catalytic site [active] 291331009586 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 291331009587 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 291331009588 putative active site [active] 291331009589 catalytic site [active] 291331009590 YceI-like domain; Region: YceI; cl01001 291331009591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 291331009592 catalytic core [active] 291331009593 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 291331009594 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 291331009595 P-loop; other site 291331009596 Magnesium ion binding site [ion binding]; other site 291331009597 Membrane transport protein; Region: Mem_trans; cl09117 291331009598 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 291331009599 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 291331009600 dimer interface [polypeptide binding]; other site 291331009601 PYR/PP interface [polypeptide binding]; other site 291331009602 TPP binding site [chemical binding]; other site 291331009603 substrate binding site [chemical binding]; other site 291331009604 TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008 291331009605 TPP-binding site; other site 291331009606 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 291331009607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 291331009608 non-specific DNA binding site [nucleotide binding]; other site 291331009609 salt bridge; other site 291331009610 sequence-specific DNA binding site [nucleotide binding]; other site 291331009611 HipA N-terminal domain; Region: couple_hipA; TIGR03071 291331009612 HipA-like N-terminal domain; Region: HipA_N; pfam07805 291331009613 HipA-like C-terminal domain; Region: HipA_C; pfam07804 291331009614 probable methyltransferase; Region: TIGR03438 291331009615 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 291331009616 TIGR03440 family protein; Region: unchr_TIGR03440 291331009617 DinB superfamily; Region: DinB_2; cl00986 291331009618 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 291331009619 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 291331009620 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 291331009621 catalytic residue [active] 291331009622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331009623 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 291331009624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 291331009625 dimer interface [polypeptide binding]; other site 291331009626 conserved gate region; other site 291331009627 ABC-ATPase subunit interface; other site 291331009628 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331009629 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 291331009630 Walker A/P-loop; other site 291331009631 ATP binding site [chemical binding]; other site 291331009632 Q-loop/lid; other site 291331009633 ABC transporter signature motif; other site 291331009634 Walker B; other site 291331009635 D-loop; other site 291331009636 H-loop/switch region; other site 291331009637 Secreted protein acidic and rich in cysteine Ca binding region; Region: SPARC_Ca_bdg; pfam10591 291331009638 Fatty acid desaturase; Region: FA_desaturase; pfam00487 291331009639 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 291331009640 Di-iron ligands [ion binding]; other site 291331009641 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 291331009642 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 291331009643 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331009644 Walker A/P-loop; other site 291331009645 ATP binding site [chemical binding]; other site 291331009646 Q-loop/lid; other site 291331009647 ABC transporter signature motif; other site 291331009648 Walker B; other site 291331009649 D-loop; other site 291331009650 H-loop/switch region; other site 291331009651 Protein of unknown function DUF124; Region: DUF124; cl00884 291331009652 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 291331009653 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 291331009654 active site 291331009655 nucleophile elbow; other site 291331009656 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331009657 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331009658 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 291331009659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331009660 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 291331009661 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 291331009662 active site 291331009663 catalytic tetrad [active] 291331009664 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 291331009665 Prostaglandin dehydrogenases; Region: PGDH; cd05288 291331009666 NAD(P) binding site [chemical binding]; other site 291331009667 substrate binding site [chemical binding]; other site 291331009668 dimer interface [polypeptide binding]; other site 291331009669 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 291331009670 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 291331009671 active site 291331009672 catalytic tetrad [active] 291331009673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 291331009674 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 291331009675 active site 291331009676 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 291331009677 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 291331009678 ATP binding site [chemical binding]; other site 291331009679 putative Mg++ binding site [ion binding]; other site 291331009680 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 291331009681 nucleotide binding region [chemical binding]; other site 291331009682 ATP-binding site [chemical binding]; other site 291331009683 Helicase associated domain (HA2); Region: HA2; cl04503 291331009684 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 291331009685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 291331009686 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 291331009687 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 291331009688 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 291331009689 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 291331009690 putative active site pocket [active] 291331009691 metal binding site [ion binding]; metal-binding site 291331009692 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 291331009693 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 291331009694 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 291331009695 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 291331009696 NAD binding site [chemical binding]; other site 291331009697 homotetramer interface [polypeptide binding]; other site 291331009698 homodimer interface [polypeptide binding]; other site 291331009699 active site 291331009700 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 291331009701 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 291331009702 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 291331009703 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 291331009704 active site 291331009705 catalytic tetrad [active] 291331009706 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 291331009707 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 291331009708 active site 291331009709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 291331009710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 291331009711 active site 291331009712 phosphorylation site [posttranslational modification] 291331009713 intermolecular recognition site; other site 291331009714 dimerization interface [polypeptide binding]; other site 291331009715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 291331009716 DNA binding residues [nucleotide binding] 291331009717 dimerization interface [polypeptide binding]; other site 291331009718 acetyl-CoA synthetase; Provisional; Region: PRK00174 291331009719 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 291331009720 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 291331009721 Protein of unknown function, DUF485; Region: DUF485; cl01231 291331009722 Sodium:solute symporter family; Region: SSF; cl00456 291331009723 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 291331009724 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 291331009725 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 291331009726 putative phosphate binding site [ion binding]; other site 291331009727 putative catalytic site [active] 291331009728 active site 291331009729 metal binding site A [ion binding]; metal-binding site 291331009730 DNA binding site [nucleotide binding] 291331009731 putative AP binding site [nucleotide binding]; other site 291331009732 putative metal binding site B [ion binding]; other site 291331009733 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 291331009734 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 291331009735 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 291331009736 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 291331009737 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 291331009738 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 291331009739 putative active site [active] 291331009740 putative metal binding site [ion binding]; other site 291331009741 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 291331009742 PhoD-like phosphatase; Region: PhoD; pfam09423 291331009743 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 291331009744 putative active site [active] 291331009745 putative metal binding site [ion binding]; other site 291331009746 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 291331009747 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 291331009748 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 291331009749 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 291331009750 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 291331009751 Transposase; Region: DDE_Tnp_ISL3; pfam01610 291331009753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 291331009754 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 291331009755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331009756 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 291331009757 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 291331009758 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 291331009759 dimerization interface [polypeptide binding]; other site 291331009760 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 291331009761 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 291331009762 putative active site [active] 291331009763 catalytic site [active] 291331009764 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 291331009765 putative active site [active] 291331009766 catalytic site [active] 291331009767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 291331009768 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 291331009769 UvrD/REP helicase; Region: UvrD-helicase; cl14126 291331009770 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 291331009771 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 291331009772 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 291331009773 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 291331009774 NAD(P) binding site [chemical binding]; other site 291331009775 RmuC family; Region: RmuC; pfam02646 291331009776 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 291331009777 catalytic residues [active] 291331009778 dimer interface [polypeptide binding]; other site 291331009779 Transposase domain (DUF772); Region: DUF772; cl12084 291331009780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 291331009781 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 291331009782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 291331009783 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 291331009784 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 291331009785 Rhomboid family; Region: Rhomboid; cl11446 291331009786 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 291331009787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 291331009788 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 291331009789 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 291331009790 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 291331009791 protein binding site [polypeptide binding]; other site 291331009792 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 291331009793 Catalytic dyad [active] 291331009794 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 291331009795 Peptidase family M23; Region: Peptidase_M23; pfam01551 291331009796 Uncharacterized conserved protein [Function unknown]; Region: COG3595 291331009797 M28, and M42; Region: Zinc_peptidase_like; cl14876 291331009798 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-...; Region: PA_M28_1_2; cd04821 291331009799 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 291331009800 PA/protease or protease-like domain interface [polypeptide binding]; other site 291331009801 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 291331009802 metal binding site [ion binding]; metal-binding site 291331009803 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 291331009804 Transposase domain (DUF772); Region: DUF772; cl12084 291331009805 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 291331009806 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 291331009807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 291331009808 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 291331009809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 291331009810 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 291331009811 Predicted ATPase [General function prediction only]; Region: COG4637 291331009812 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 291331009813 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 291331009814 GTP cyclohydrolase I; Provisional; Region: PLN03044 291331009815 active site 291331009817 Fusaric acid resistance protein family; Region: FUSC; pfam04632 291331009818 Fusaric acid resistance protein family; Region: FUSC; pfam04632 291331009819 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 291331009820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331009821 putative substrate translocation pore; other site 291331009823 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 291331009824 Transposase domain (DUF772); Region: DUF772; cl12084 291331009825 Uncharacterized conserved protein [Function unknown]; Region: COG4104 291331009826 PAAR motif; Region: PAAR_motif; pfam05488 291331009827 Glycerate kinase family; Region: Gly_kinase; cl00841 291331009828 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 291331009829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 291331009830 putative substrate translocation pore; other site 291331009831 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 291331009832 active site 291331009833 dimer interface [polypeptide binding]; other site 291331009834 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 291331009835 PUA domain; Region: PUA; cl00607 291331009836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 291331009837 S-adenosylmethionine binding site [chemical binding]; other site 291331009838 Integral membrane protein TerC family; Region: TerC; cl10468 291331009839 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 291331009840 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 291331009841 putative active site [active] 291331009842 catalytic site [active] 291331009843 putative metal binding site [ion binding]; other site 291331009845 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role...; Region: PAP2_acid_phosphatase; cd03397 291331009846 active site 291331009847 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 291331009848 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 291331009849 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 291331009850 G1 box; other site 291331009851 GTP/Mg2+ binding site [chemical binding]; other site 291331009852 Switch I region; other site 291331009853 G2 box; other site 291331009854 Switch II region; other site 291331009855 G3 box; other site 291331009856 G4 box; other site 291331009857 G5 box; other site 291331009858 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 291331009859 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 291331009860 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 291331009861 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 291331009862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 291331009863 binding surface 291331009864 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 291331009865 TPR motif; other site 291331009866 membrane protein insertase; Provisional; Region: PRK01318 291331009867 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 291331009868 Ribonuclease P; Region: Ribonuclease_P; cl00457