-- dump date   	20111121_015704
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
342109000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
342109000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109000003	Walker A motif; other site
342109000004	ATP binding site [chemical binding]; other site
342109000005	Walker B motif; other site
342109000006	arginine finger; other site
342109000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
342109000008	DnaA box-binding interface [nucleotide binding]; other site
342109000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
342109000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140
342109000011	putative DNA binding surface [nucleotide binding]; other site
342109000012	dimer interface [polypeptide binding]; other site
342109000013	beta-clamp/clamp loader binding surface; other site
342109000014	beta-clamp/translesion DNA polymerase binding surface; other site
342109000015	recombination protein F; Reviewed; Region: recF; PRK00064
342109000016	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109000017	Walker A/P-loop; other site
342109000018	ATP binding site [chemical binding]; other site
342109000019	Q-loop/lid; other site
342109000020	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109000021	ABC transporter signature motif; other site
342109000022	Walker B; other site
342109000023	D-loop; other site
342109000024	H-loop/switch region; other site
342109000025	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
342109000026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
342109000027	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
342109000028	anchoring element; other site
342109000029	dimer interface [polypeptide binding]; other site
342109000030	ATP binding site [chemical binding]; other site
342109000031	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
342109000032	active site
342109000033	putative metal-binding site [ion binding]; other site
342109000034	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
342109000035	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
342109000036	Peptidase family M48; Region: Peptidase_M48; cl12018
342109000037	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
342109000038	Gram-negative bacterial tonB protein; Region: TonB; cl10048
342109000039	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
342109000040	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
342109000041	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
342109000042	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
342109000043	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
342109000044	active site
342109000045	hydrophilic channel; other site
342109000046	dimerization interface [polypeptide binding]; other site
342109000047	catalytic residues [active]
342109000048	active site lid [active]
342109000049	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
342109000050	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
342109000051	putative active site [active]
342109000052	catalytic site [active]
342109000053	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
342109000054	putative active site [active]
342109000055	catalytic site [active]
342109000056	fructose-1,6-bisphosphatase family protein; Region: PLN02628
342109000057	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354
342109000058	AMP binding site [chemical binding]; other site
342109000059	metal binding site [ion binding]; metal-binding site
342109000060	active site
342109000061	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342109000062	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109000063	homodimer interface [polypeptide binding]; other site
342109000064	catalytic residue [active]
342109000065	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
342109000066	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109000067	N-terminal plug; other site
342109000068	ligand-binding site [chemical binding]; other site
342109000069	Transposase domain (DUF772); Region: DUF772; cl12084
342109000070	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109000071	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
342109000072	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
342109000073	phosphate binding site [ion binding]; other site
342109000074	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
342109000075	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209
342109000076	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
342109000077	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
342109000078	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109000079	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
342109000080	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
342109000081	substrate binding site [chemical binding]; other site
342109000082	ATP binding site [chemical binding]; other site
342109000083	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109000084	Transposase domain (DUF772); Region: DUF772; cl12084
342109000085	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109000086	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
342109000087	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109000088	Walker A/P-loop; other site
342109000089	ATP binding site [chemical binding]; other site
342109000090	Q-loop/lid; other site
342109000091	ABC transporter signature motif; other site
342109000092	Walker B; other site
342109000093	D-loop; other site
342109000094	H-loop/switch region; other site
342109000095	Transposase domain (DUF772); Region: DUF772; cl12084
342109000096	Transposase domain (DUF772); Region: DUF772; cl12084
342109000097	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
342109000098	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109000099	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109000100	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
342109000101	Transposase domain (DUF772); Region: DUF772; cl12084
342109000102	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109000103	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
342109000104	DEAD-like helicases superfamily; Region: DEXDc; smart00487
342109000105	ATP binding site [chemical binding]; other site
342109000106	putative Mg++ binding site [ion binding]; other site
342109000107	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109000108	nucleotide binding region [chemical binding]; other site
342109000109	ATP-binding site [chemical binding]; other site
342109000110	VirK protein; Region: VirK; pfam06903
342109000111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
342109000112	hypothetical protein; Provisional; Region: PRK09897
342109000113	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000114	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000115	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000116	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000117	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000118	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109000119	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
342109000120	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109000121	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109000122	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109000123	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
342109000124	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109000125	NAD(P) binding site [chemical binding]; other site
342109000126	active site
342109000127	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
342109000128	Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856
342109000129	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
342109000130	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
342109000131	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
342109000132	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
342109000133	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
342109000134	Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853
342109000135	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
342109000136	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
342109000137	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
342109000138	glycogen branching enzyme; Provisional; Region: PRK12568
342109000139	Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855
342109000140	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
342109000141	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
342109000142	glycogen synthase; Provisional; Region: glgA; PRK00654
342109000143	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
342109000144	ADP-binding pocket [chemical binding]; other site
342109000145	homodimer interface [polypeptide binding]; other site
342109000146	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109000147	metal binding site [ion binding]; metal-binding site
342109000148	active site
342109000149	I-site; other site
342109000150	Uncharacterised BCR, COG1649; Region: DUF187; pfam02638
342109000151	Protein of unknown function (DUF808); Region: DUF808; cl01002
342109000152	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
342109000153	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
342109000154	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
342109000155	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000156	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000157	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
342109000158	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
342109000159	Mechanosensitive ion channel; Region: MS_channel; pfam00924
342109000160	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109000161	Integrase core domain; Region: rve; cl01316
342109000162	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
342109000163	N-acetyl-D-glucosamine binding site [chemical binding]; other site
342109000164	catalytic residue [active]
342109000165	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
342109000166	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
342109000167	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
342109000168	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
342109000169	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
342109000170	Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720
342109000171	type III secretion system ATPase; Provisional; Region: PRK09099
342109000172	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
342109000173	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
342109000174	Walker A motif/ATP binding site; other site
342109000175	Walker B motif; other site
342109000176	type III secretion system protein HrpB; Validated; Region: PRK09098
342109000177	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
342109000178	Bacterial type III secretion protein (HrpB4); Region: HrpB4; cl09735
342109000179	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
342109000180	Bacterial type III secretion protein (HrpB2); Region: HrpB2; cl09721
342109000181	Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; cl09830
342109000182	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
342109000183	FlhB HrpN YscU SpaS Family; Region: Bac_export_2; pfam01312
342109000184	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
342109000185	FHIPEP family; Region: FHIPEP; pfam00771
342109000186	Type III secretion protein (HpaP); Region: HpaP; cl09717
342109000187	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
342109000188	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
342109000189	FliP family; Region: FliP; cl00593
342109000190	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
342109000191	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
342109000192	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109000193	Transposase domain (DUF772); Region: DUF772; cl12084
342109000194	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109000195	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109000196	Transposase domain (DUF772); Region: DUF772; cl12084
342109000197	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109000198	NolX protein; Region: NolX; pfam05819
342109000199	leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113
342109000200	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
342109000201	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
342109000202	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
342109000203	protein binding site [polypeptide binding]; other site
342109000204	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
342109000205	protein binding site [polypeptide binding]; other site
342109000206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
342109000207	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
342109000208	TIGR01777 family protein; Region: yfcH
342109000209	putative NAD(P) binding site [chemical binding]; other site
342109000210	putative active site [active]
342109000211	Transposase domain (DUF772); Region: DUF772; cl12084
342109000212	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109000213	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109000214	Integrase core domain; Region: rve; cl01316
342109000215	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109000216	Integrase core domain; Region: rve; cl01316
342109000217	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
342109000218	active site
342109000219	Zn binding site [ion binding]; other site
342109000220	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_20; cd04679
342109000221	nudix motif; other site
342109000222	Protein required for attachment to host cells; Region: Host_attach; cl02398
342109000223	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
342109000224	catalytic residues [active]
342109000225	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109000226	Integrase core domain; Region: rve; cl01316
342109000227	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
342109000228	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000229	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
342109000230	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
342109000231	Walker A/P-loop; other site
342109000232	ATP binding site [chemical binding]; other site
342109000233	Q-loop/lid; other site
342109000234	ABC transporter signature motif; other site
342109000235	Walker B; other site
342109000236	D-loop; other site
342109000237	H-loop/switch region; other site
342109000238	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
342109000239	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
342109000240	FtsX-like permease family; Region: FtsX; pfam02687
342109000241	Integrase core domain; Region: rve; cl01316
342109000242	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109000243	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109000244	HSP20-like domain of unknown function (DUF1813); Region: DUF1813; cl07446
342109000245	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
342109000246	Phd_YefM; Region: PhdYeFM; cl09153
342109000247	Haemolysin-III related; Region: HlyIII; cl03831
342109000248	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
342109000249	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342109000250	ATP binding site [chemical binding]; other site
342109000251	putative Mg++ binding site [ion binding]; other site
342109000252	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109000253	nucleotide binding region [chemical binding]; other site
342109000254	ATP-binding site [chemical binding]; other site
342109000255	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
342109000256	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
342109000257	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
342109000258	active site
342109000259	substrate binding site [chemical binding]; other site
342109000260	catalytic site [active]
342109000261	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
342109000262	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
342109000263	putative active site [active]
342109000264	catalytic site [active]
342109000265	putative metal binding site [ion binding]; other site
342109000266	oligomer interface [polypeptide binding]; other site
342109000267	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
342109000268	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
342109000269	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109000270	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109000271	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109000272	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
342109000273	Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975
342109000274	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
342109000275	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109000276	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
342109000277	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes...; Region: Topo_IB_C; cd00659
342109000278	DNA binding site [nucleotide binding]
342109000279	active site
342109000280	Int/Topo IB signature motif; other site
342109000281	catalytic residues [active]
342109000282	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
342109000283	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
342109000284	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713
342109000285	active site
342109000286	dimer interface [polypeptide binding]; other site
342109000287	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
342109000288	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808
342109000289	active site
342109000290	FMN binding site [chemical binding]; other site
342109000291	substrate binding site [chemical binding]; other site
342109000292	3Fe-4S cluster binding site [ion binding]; other site
342109000293	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
342109000294	domain interface; other site
342109000295	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
342109000296	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109000297	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109000298	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109000299	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109000300	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109000301	Integrase core domain; Region: rve; cl01316
342109000302	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000303	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000304	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000305	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000306	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000307	Transposase domain (DUF772); Region: DUF772; cl12084
342109000308	KduI/IolB family; Region: KduI; cl01508
342109000309	KduI/IolB family; Region: KduI; cl01508
342109000310	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342109000311	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342109000312	DNA binding site [nucleotide binding]
342109000313	domain linker motif; other site
342109000314	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
342109000315	putative dimerization interface [polypeptide binding]; other site
342109000316	putative ligand binding site [chemical binding]; other site
342109000317	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
342109000318	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
342109000319	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
342109000320	active site
342109000321	metal binding site [ion binding]; metal-binding site
342109000322	glycogen branching enzyme; Provisional; Region: PRK05402
342109000323	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
342109000324	Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855
342109000325	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
342109000326	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
342109000327	trehalose synthase; Region: treS_nterm; TIGR02456
342109000328	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
342109000329	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
342109000330	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286
342109000331	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
342109000332	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
342109000333	putative transposase OrfB; Reviewed; Region: PHA02517
342109000334	Integrase core domain; Region: rve; cl01316
342109000335	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109000336	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109000337	Transposase, Mutator family; Region: Transposase_mut; pfam00872
342109000338	MULE transposase domain; Region: MULE; pfam10551
342109000339	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109000340	Transposase domain (DUF772); Region: DUF772; cl12084
342109000341	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109000342	Mg chelatase-related protein; Region: TIGR00368
342109000343	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109000344	Membrane fusogenic activity; Region: BMFP; cl01115
342109000345	Nitrogen regulatory protein P-II; Region: P-II; cl00412
342109000346	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
342109000347	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
342109000348	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109000349	spermidine synthase; Provisional; Region: PRK00811
342109000350	arginine decarboxylase; Provisional; Region: PRK05354
342109000351	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
342109000352	dimer interface [polypeptide binding]; other site
342109000353	active site
342109000354	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
342109000355	catalytic residues [active]
342109000356	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
342109000357	Transposase domain (DUF772); Region: DUF772; cl12084
342109000358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000359	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000360	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109000361	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109000362	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109000363	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
342109000364	Protein of unknown function (DUF3274); Region: DUF3274; pfam11678
342109000365	Protein of unknown function (DUF2875); Region: DUF2875; pfam11394
342109000366	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
342109000367	Protein of unknown function (DUF3274); Region: DUF3274; pfam11678
342109000368	Protein of unknown function (DUF2875); Region: DUF2875; pfam11394
342109000369	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
342109000370	Protein of unknown function (DUF3274); Region: DUF3274; pfam11678
342109000371	Protein of unknown function (DUF2875); Region: DUF2875; pfam11394
342109000372	Uncharacterized conserved protein [Function unknown]; Region: COG4104
342109000373	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520
342109000374	Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445
342109000375	serine racemase; Region: PLN02970
342109000376	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
342109000377	tetramer interface [polypeptide binding]; other site
342109000378	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109000379	catalytic residue [active]
342109000380	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
342109000381	putative active site [active]
342109000382	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
342109000383	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426
342109000384	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
342109000385	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109000386	S-adenosylmethionine binding site [chemical binding]; other site
342109000387	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
342109000388	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
342109000389	putative NAD(P) binding site [chemical binding]; other site
342109000390	putative active site [active]
342109000391	putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738
342109000392	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl01208
342109000393	GAF domain; Region: GAF; cl00853
342109000394	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
342109000395	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
342109000396	Thymidine kinase; Region: TK; cl00631
342109000397	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
342109000398	UvrD/REP helicase; Region: UvrD-helicase; cl14126
342109000399	hypothetical protein; Provisional; Region: PRK11239
342109000400	Protein of unknown function, DUF480; Region: DUF480; cl01209
342109000401	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
342109000402	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
342109000403	active site
342109000404	dimer interface [polypeptide binding]; other site
342109000405	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109000406	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
342109000407	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109000408	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
342109000409	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109000410	lac repressor; Reviewed; Region: lacI; PRK09526
342109000411	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342109000412	DNA binding site [nucleotide binding]
342109000413	domain linker motif; other site
342109000414	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
342109000415	dimerization interface [polypeptide binding]; other site
342109000416	ligand binding site [chemical binding]; other site
342109000417	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
342109000418	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
342109000419	putative acyl-acceptor binding pocket; other site
342109000420	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
342109000421	NAD(P) binding site [chemical binding]; other site
342109000422	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
342109000423	Protein of unknown function (DUF465); Region: DUF465; cl01070
342109000424	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109000425	Integrase core domain; Region: rve; cl01316
342109000426	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
342109000427	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
342109000428	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
342109000429	active site
342109000430	oxyanion hole [active]
342109000431	Protein of unknown function (DUF3532); Region: DUF3532; pfam12050
342109000432	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH)...; Region: pro_PheOH; cd03348
342109000433	cofactor binding site; other site
342109000434	metal binding site [ion binding]; metal-binding site
342109000435	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109000436	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109000437	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109000438	Transposase domain (DUF772); Region: DUF772; cl12084
342109000439	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
342109000440	Transposase domain (DUF772); Region: DUF772; cl12084
342109000441	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000442	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109000443	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109000444	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
342109000445	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
342109000446	putative NAD(P) binding site [chemical binding]; other site
342109000447	putative substrate binding site [chemical binding]; other site
342109000448	catalytic Zn binding site [ion binding]; other site
342109000449	structural Zn binding site [ion binding]; other site
342109000450	dimer interface [polypeptide binding]; other site
342109000451	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895
342109000452	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895
342109000453	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895
342109000454	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109000455	hypothetical protein; Provisional; Region: PRK04233
342109000456	SEC-C motif; Region: SEC-C; cl12132
342109000457	Transposase domain (DUF772); Region: DUF772; cl12084
342109000458	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109000459	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
342109000460	lytic murein transglycosylase; Region: MltB_2; TIGR02283
342109000461	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
342109000462	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
342109000463	active site
342109000464	phosphate binding residues; other site
342109000465	catalytic residues [active]
342109000466	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109000467	putative substrate translocation pore; other site
342109000468	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
342109000469	heme binding pocket [chemical binding]; other site
342109000470	heme ligand [chemical binding]; other site
342109000471	PAS fold; Region: PAS_2; pfam08446
342109000472	GAF domain; Region: GAF; cl00853
342109000473	Phytochrome region; Region: PHY; pfam00360
342109000474	Sulfate transporter family; Region: Sulfate_transp; cl00967
342109000475	Sulfate transporter family; Region: Sulfate_transp; cl00967
342109000476	Integrase core domain; Region: rve; cl01316
342109000477	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109000478	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109000479	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
342109000480	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
342109000481	DNA binding site [nucleotide binding]
342109000482	catalytic residue [active]
342109000483	H2TH interface [polypeptide binding]; other site
342109000484	putative catalytic residues [active]
342109000485	turnover-facilitating residue; other site
342109000486	intercalation triad [nucleotide binding]; other site
342109000487	8OG recognition residue [nucleotide binding]; other site
342109000488	putative reading head residues; other site
342109000489	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
342109000490	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
342109000491	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109000492	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109000493	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000494	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000495	Transposase domain (DUF772); Region: DUF772; cl12084
342109000496	VacJ like lipoprotein; Region: VacJ; cl01073
342109000497	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
342109000498	ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074
342109000499	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
342109000500	mce related protein; Region: MCE; cl03606
342109000501	Domain of unknown function DUF140; Region: DUF140; cl00510
342109000502	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
342109000503	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
342109000504	Walker A/P-loop; other site
342109000505	ATP binding site [chemical binding]; other site
342109000506	Q-loop/lid; other site
342109000507	ABC transporter signature motif; other site
342109000508	Walker B; other site
342109000509	D-loop; other site
342109000510	H-loop/switch region; other site
342109000511	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109000512	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109000513	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109000514	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109000515	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109000516	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109000517	Integrase core domain; Region: rve; cl01316
342109000518	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000519	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000520	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000521	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000522	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000523	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000524	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000525	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000526	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000527	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000528	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109000529	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109000530	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109000531	Integrase core domain; Region: rve; cl01316
342109000532	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109000533	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505
342109000534	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
342109000535	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
342109000536	Trp docking motif; other site
342109000537	'Velcro' closure; other site
342109000538	active site
342109000539	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000540	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000541	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
342109000542	ATP-binding site [chemical binding]; other site
342109000543	Gluconate-6-phosphate binding site [chemical binding]; other site
342109000544	putative symporter YagG; Provisional; Region: PRK09669
342109000545	putative transporter; Provisional; Region: PRK11462
342109000546	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
342109000547	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
342109000548	Sodium:solute symporter family; Region: SSF; cl00456
342109000549	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
342109000550	PAS fold; Region: PAS_7; pfam12860
342109000551	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109000552	dimer interface [polypeptide binding]; other site
342109000553	phosphorylation site [posttranslational modification]
342109000554	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109000555	ATP binding site [chemical binding]; other site
342109000556	Mg2+ binding site [ion binding]; other site
342109000557	G-X-G motif; other site
342109000558	Response regulator receiver domain; Region: Response_reg; pfam00072
342109000559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109000560	active site
342109000561	phosphorylation site [posttranslational modification]
342109000562	intermolecular recognition site; other site
342109000563	dimerization interface [polypeptide binding]; other site
342109000564	Predicted membrane protein [Function unknown]; Region: COG1971
342109000565	Domain of unknown function DUF; Region: DUF204; pfam02659
342109000566	Domain of unknown function DUF; Region: DUF204; pfam02659
342109000567	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109000568	Bacterial transcriptional regulator; Region: IclR; pfam01614
342109000569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
342109000570	glucose/galactose transporter; Region: gluP; TIGR01272
342109000571	Domain of unknown function (DUF718); Region: DUF718; cl01281
342109000572	Transposase domain (DUF772); Region: DUF772; cl12084
342109000573	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109000574	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109000575	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
342109000576	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
342109000577	active site
342109000578	Zn binding site [ion binding]; other site
342109000579	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
342109000580	putative acyl-acceptor binding pocket; other site
342109000581	RF-1 domain; Region: RF-1; cl02875
342109000582	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
342109000583	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
342109000584	active site
342109000585	Cupin domain; Region: Cupin_2; cl09118
342109000586	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
342109000587	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
342109000588	SCP-2 sterol transfer family; Region: SCP2; cl01225
342109000589	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
342109000590	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
342109000591	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109000592	Transposase domain (DUF772); Region: DUF772; cl12084
342109000593	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000594	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000595	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000596	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000597	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000598	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109000599	Integrase core domain; Region: rve; cl01316
342109000600	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109000601	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109000602	Transposase domain (DUF772); Region: DUF772; cl12084
342109000603	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109000604	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109000605	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109000606	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109000607	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
342109000608	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109000609	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
342109000610	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
342109000611	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
342109000612	ABC-2 type transporter; Region: ABC2_membrane; cl11417
342109000613	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
342109000614	The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263
342109000615	Walker A/P-loop; other site
342109000616	ATP binding site [chemical binding]; other site
342109000617	Q-loop/lid; other site
342109000618	ABC transporter signature motif; other site
342109000619	Walker B; other site
342109000620	D-loop; other site
342109000621	H-loop/switch region; other site
342109000622	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
342109000623	FAD binding pocket [chemical binding]; other site
342109000624	FAD binding motif [chemical binding]; other site
342109000625	phosphate binding motif [ion binding]; other site
342109000626	beta-alpha-beta structure motif; other site
342109000627	NAD binding pocket [chemical binding]; other site
342109000628	Cation efflux family; Region: Cation_efflux; cl00316
342109000629	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
342109000630	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
342109000631	putative metal binding site [ion binding]; other site
342109000632	putative homotetramer interface [polypeptide binding]; other site
342109000633	putative homodimer interface [polypeptide binding]; other site
342109000634	putative homodimer-homodimer interface [polypeptide binding]; other site
342109000635	putative allosteric switch controlling residues; other site
342109000636	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342109000637	non-specific DNA binding site [nucleotide binding]; other site
342109000638	salt bridge; other site
342109000639	sequence-specific DNA binding site [nucleotide binding]; other site
342109000640	proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
342109000641	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
342109000642	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109000643	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
342109000644	NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake.  NatB possess six putative membrane spanning regions at...; Region: ABC_NatA_sodium_exporter; cd03266
342109000645	Walker A/P-loop; other site
342109000646	ATP binding site [chemical binding]; other site
342109000647	Q-loop/lid; other site
342109000648	ABC transporter signature motif; other site
342109000649	Walker B; other site
342109000650	D-loop; other site
342109000651	H-loop/switch region; other site
342109000652	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
342109000653	ABC-2 type transporter; Region: ABC2_membrane; cl11417
342109000654	Gram-negative bacterial tonB protein; Region: TonB; cl10048
342109000655	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109000656	SapC; Region: SapC; pfam07277
342109000657	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109000658	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109000659	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109000660	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109000661	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000662	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109000663	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
342109000664	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048
342109000665	C-terminal domain interface [polypeptide binding]; other site
342109000666	GSH binding site (G-site) [chemical binding]; other site
342109000667	dimer interface [polypeptide binding]; other site
342109000668	GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178
342109000669	dimer interface [polypeptide binding]; other site
342109000670	N-terminal domain interface [polypeptide binding]; other site
342109000671	putative substrate binding pocket (H-site) [chemical binding]; other site
342109000672	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
342109000673	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
342109000674	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
342109000675	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109000676	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
342109000677	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
342109000678	dimer interface [polypeptide binding]; other site
342109000679	allosteric magnesium binding site [ion binding]; other site
342109000680	active site
342109000681	aspartate-rich active site metal binding site; other site
342109000682	Schiff base residues; other site
342109000683	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109000684	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109000685	NAD(P) binding site [chemical binding]; other site
342109000686	active site
342109000687	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109000688	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109000689	dimerization interface [polypeptide binding]; other site
342109000690	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
342109000691	active site
342109000692	substrate binding site [chemical binding]; other site
342109000693	Mg2+ binding site [ion binding]; other site
342109000694	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
342109000695	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
342109000696	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
342109000697	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
342109000698	FAD binding pocket [chemical binding]; other site
342109000699	FAD binding motif [chemical binding]; other site
342109000700	catalytic residues [active]
342109000701	NAD binding pocket [chemical binding]; other site
342109000702	phosphate binding motif [ion binding]; other site
342109000703	beta-alpha-beta structure motif; other site
342109000704	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
342109000705	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
342109000706	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
342109000707	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
342109000708	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
342109000709	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
342109000710	NAD(P) binding site [chemical binding]; other site
342109000711	shikimate binding site; other site
342109000712	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
342109000713	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250
342109000714	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
342109000715	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109000716	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109000717	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
342109000718	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404
342109000719	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
342109000720	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
342109000721	tetramer interface [polypeptide binding]; other site
342109000722	heme binding pocket [chemical binding]; other site
342109000723	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
342109000724	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
342109000725	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
342109000726	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
342109000727	FMN binding site [chemical binding]; other site
342109000728	active site
342109000729	catalytic residues [active]
342109000730	substrate binding site [chemical binding]; other site
342109000731	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
342109000732	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
342109000733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109000734	active site
342109000735	phosphorylation site [posttranslational modification]
342109000736	intermolecular recognition site; other site
342109000737	dimerization interface [polypeptide binding]; other site
342109000738	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109000739	DNA binding site [nucleotide binding]
342109000740	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
342109000741	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109000742	dimer interface [polypeptide binding]; other site
342109000743	phosphorylation site [posttranslational modification]
342109000744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109000745	ATP binding site [chemical binding]; other site
342109000746	G-X-G motif; other site
342109000747	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
342109000748	Protein of unknown function (DUF1501); Region: DUF1501; cl01699
342109000749	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
342109000750	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
342109000751	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109000752	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
342109000753	Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130
342109000754	Sporulation related domain; Region: SPOR; cl10051
342109000755	thymidylate kinase; Validated; Region: tmk; PRK00698
342109000756	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672
342109000757	TMP-binding site; other site
342109000758	ATP-binding site [chemical binding]; other site
342109000759	Picornavirus 2B protein; Region: Pico_P2B; pfam01552
342109000760	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
342109000761	Arginase family; Region: Arginase; cl00306
342109000762	Entericidin EcnA/B family; Region: Entericidin; cl02322
342109000763	CsbD-like; Region: CsbD; cl01272
342109000764	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
342109000765	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
342109000766	active site
342109000767	HIGH motif; other site
342109000768	dimer interface [polypeptide binding]; other site
342109000769	KMSKS motif; other site
342109000770	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
342109000771	M28, and M42; Region: Zinc_peptidase_like; cl14876
342109000772	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-...; Region: PA_M28_1_2; cd04821
342109000773	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
342109000774	PA/protease or protease-like domain interface [polypeptide binding]; other site
342109000775	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
342109000776	metal binding site [ion binding]; metal-binding site
342109000777	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
342109000778	EamA-like transporter family; Region: EamA; cl01037
342109000779	Predicted permeases [General function prediction only]; Region: RarD; COG2962
342109000780	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
342109000781	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859
342109000782	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
342109000783	putative heme binding pocket [chemical binding]; other site
342109000784	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342109000785	RNA polymerase sigma factor; Provisional; Region: PRK12511
342109000786	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433
342109000787	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
342109000788	interface (dimer of trimers) [polypeptide binding]; other site
342109000789	Substrate-binding/catalytic site; other site
342109000790	Zn-binding sites [ion binding]; other site
342109000791	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
342109000792	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
342109000793	motif II; other site
342109000794	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
342109000795	Domain of unknown function DUF20; Region: UPF0118; cl00465
342109000796	UbiA prenyltransferase family; Region: UbiA; cl00337
342109000797	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
342109000798	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
342109000799	biotin synthase; Provisional; Region: PRK15108
342109000800	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
342109000801	FeS/SAM binding site; other site
342109000802	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
342109000803	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
342109000804	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109000805	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109000806	catalytic residue [active]
342109000807	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109000808	Integrase core domain; Region: rve; cl01316
342109000809	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109000810	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
342109000811	NAD(P) binding site [chemical binding]; other site
342109000812	active site
342109000813	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
342109000814	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109000815	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
342109000816	Ligand binding site [chemical binding]; other site
342109000817	Putative Catalytic site [active]
342109000818	DXD motif; other site
342109000819	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
342109000820	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
342109000821	dimer interface [polypeptide binding]; other site
342109000822	active site
342109000823	YcgL domain; Region: YcgL; cl01189
342109000824	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
342109000825	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
342109000826	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
342109000827	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
342109000828	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
342109000829	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
342109000830	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
342109000831	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
342109000832	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
342109000833	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
342109000834	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
342109000835	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
342109000836	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
342109000837	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109000838	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
342109000839	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
342109000840	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109000841	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
342109000842	MgtE intracellular N domain; Region: MgtE_N; cl15244
342109000843	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
342109000844	Divalent cation transporter; Region: MgtE; cl00786
342109000845	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
342109000846	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109000847	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109000848	Integral membrane protein TerC family; Region: TerC; cl10468
342109000849	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209
342109000850	Class I ribonucleotide reductase; Region: RNR_I; cd01679
342109000851	active site
342109000852	dimer interface [polypeptide binding]; other site
342109000853	catalytic residues [active]
342109000854	effector binding site; other site
342109000855	R2 peptide binding site; other site
342109000856	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
342109000857	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
342109000858	dimer interface [polypeptide binding]; other site
342109000859	putative radical transfer pathway; other site
342109000860	diiron center [ion binding]; other site
342109000861	tyrosyl radical; other site
342109000862	Domain of unknown function (DUF955); Region: DUF955; cl01076
342109000863	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
342109000864	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
342109000865	catalytic residues [active]
342109000866	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109000867	putative transposase OrfB; Reviewed; Region: PHA02517
342109000868	Integrase core domain; Region: rve; cl01316
342109000869	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
342109000870	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
342109000871	dimer interface [polypeptide binding]; other site
342109000872	active site
342109000873	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383
342109000874	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
342109000875	Active site [active]
342109000876	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
342109000877	heterodimer interface [polypeptide binding]; other site
342109000878	active site
342109000879	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
342109000880	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
342109000881	tetramer interface [polypeptide binding]; other site
342109000882	active site
342109000883	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
342109000884	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
342109000885	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
342109000886	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109000887	Bacterial transcriptional regulator; Region: IclR; pfam01614
342109000888	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
342109000889	ATP binding site [chemical binding]; other site
342109000890	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109000891	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
342109000892	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109000893	NAD(P) binding site [chemical binding]; other site
342109000894	active site
342109000895	Sporulation related domain; Region: SPOR; cl10051
342109000896	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
342109000897	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
342109000898	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
342109000899	active site
342109000900	HIGH motif; other site
342109000901	KMSK motif region; other site
342109000902	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
342109000903	tRNA binding surface [nucleotide binding]; other site
342109000904	anticodon binding site; other site
342109000905	hypothetical protein; Reviewed; Region: PRK00024
342109000906	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
342109000907	MPN+ (JAMM) motif; other site
342109000908	Zinc-binding site [ion binding]; other site
342109000909	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
342109000910	Flavoprotein; Region: Flavoprotein; cl08021
342109000911	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
342109000912	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
342109000913	trimer interface [polypeptide binding]; other site
342109000914	active site
342109000915	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
342109000916	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
342109000917	active site
342109000918	substrate binding site [chemical binding]; other site
342109000919	metal binding site [ion binding]; metal-binding site
342109000920	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
342109000921	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
342109000922	Ligand binding site [chemical binding]; other site
342109000923	Putative Catalytic site [active]
342109000924	DXD motif; other site
342109000925	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
342109000926	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
342109000927	putative NAD(P) binding site [chemical binding]; other site
342109000928	active site
342109000929	putative substrate binding site [chemical binding]; other site
342109000930	TfoX N-terminal domain; Region: TfoX_N; cl01167
342109000931	ParB-like partition proteins; Region: parB_part; TIGR00180
342109000932	ParB-like nuclease domain; Region: ParBc; cl02129
342109000933	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
342109000934	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
342109000935	P-loop; other site
342109000936	Magnesium ion binding site [ion binding]; other site
342109000937	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
342109000938	Magnesium ion binding site [ion binding]; other site
342109000939	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
342109000940	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
342109000941	putative active site [active]
342109000942	putative DNA binding site [nucleotide binding]; other site
342109000943	putative phosphate binding site [ion binding]; other site
342109000944	putative catalytic site [active]
342109000945	metal binding site A [ion binding]; metal-binding site
342109000946	putative AP binding site [nucleotide binding]; other site
342109000947	putative metal binding site B [ion binding]; other site
342109000948	muropeptide transporter; Reviewed; Region: ampG; PRK11902
342109000949	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
342109000950	Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217
342109000951	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
342109000952	putative peptidase; Provisional; Region: PRK11649
342109000953	Peptidase family M23; Region: Peptidase_M23; pfam01551
342109000954	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
342109000955	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
342109000956	active site
342109000957	HIGH motif; other site
342109000958	dimer interface [polypeptide binding]; other site
342109000959	KMSKS motif; other site
342109000960	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109000961	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109000962	dimer interface [polypeptide binding]; other site
342109000963	phosphorylation site [posttranslational modification]
342109000964	histidine kinase; Provisional; Region: PRK13557
342109000965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109000966	ATP binding site [chemical binding]; other site
342109000967	Mg2+ binding site [ion binding]; other site
342109000968	G-X-G motif; other site
342109000969	Response regulator receiver domain; Region: Response_reg; pfam00072
342109000970	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109000971	active site
342109000972	phosphorylation site [posttranslational modification]
342109000973	intermolecular recognition site; other site
342109000974	dimerization interface [polypeptide binding]; other site
342109000975	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
342109000976	Response regulator receiver domain; Region: Response_reg; pfam00072
342109000977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109000978	active site
342109000979	phosphorylation site [posttranslational modification]
342109000980	intermolecular recognition site; other site
342109000981	dimerization interface [polypeptide binding]; other site
342109000982	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
342109000983	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
342109000984	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
342109000985	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
342109000986	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
342109000987	Secretory lipase; Region: LIP; pfam03583
342109000988	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
342109000989	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
342109000990	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
342109000991	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
342109000992	putative NADH binding site [chemical binding]; other site
342109000993	putative active site [active]
342109000994	nudix motif; other site
342109000995	putative metal binding site [ion binding]; other site
342109000996	CobD/Cbib protein; Region: CobD_Cbib; cl00561
342109000997	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
342109000998	Interferon-induced transmembrane protein; Region: CD225; pfam04505
342109000999	H+ Antiporter protein; Region: 2A0121; TIGR00900
342109001000	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
342109001001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109001002	putative substrate translocation pore; other site
342109001003	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
342109001004	putative acyl-acceptor binding pocket; other site
342109001005	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109001006	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
342109001007	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
342109001008	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
342109001009	Predicted ATPase [General function prediction only]; Region: COG4637
342109001010	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109001011	Walker A/P-loop; other site
342109001012	ATP binding site [chemical binding]; other site
342109001013	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
342109001014	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
342109001015	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
342109001016	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109001017	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
342109001018	Predicted ATPase [General function prediction only]; Region: COG4637
342109001019	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109001020	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
342109001021	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421
342109001022	purine monophosphate binding site [chemical binding]; other site
342109001023	dimer interface [polypeptide binding]; other site
342109001024	putative catalytic residues [active]
342109001025	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
342109001026	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
342109001027	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
342109001028	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109001029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109001030	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109001031	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109001032	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
342109001033	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
342109001034	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
342109001035	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
342109001036	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
342109001037	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
342109001038	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
342109001039	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
342109001040	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109001041	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
342109001042	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
342109001043	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
342109001044	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
342109001045	carboxyltransferase (CT) interaction site; other site
342109001046	biotinylation site [posttranslational modification]; other site
342109001047	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
342109001048	active site
342109001049	trimer interface [polypeptide binding]; other site
342109001050	dimer interface [polypeptide binding]; other site
342109001051	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
342109001052	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
342109001053	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
342109001054	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515
342109001055	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
342109001056	DsbD alpha interface [polypeptide binding]; other site
342109001057	catalytic residues [active]
342109001058	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
342109001059	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109001060	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109001061	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109001062	Transposase; Region: DEDD_Tnp_IS110; pfam01548
342109001063	primosome assembly protein PriA; Validated; Region: PRK05580
342109001064	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342109001065	ATP binding site [chemical binding]; other site
342109001066	putative Mg++ binding site [ion binding]; other site
342109001067	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
342109001068	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
342109001069	multidrug efflux protein; Reviewed; Region: PRK01766
342109001070	MatE; Region: MatE; pfam01554
342109001071	MatE; Region: MatE; pfam01554
342109001072	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
342109001073	tandem repeat interface [polypeptide binding]; other site
342109001074	oligomer interface [polypeptide binding]; other site
342109001075	active site residues [active]
342109001076	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
342109001077	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
342109001078	tandem repeat interface [polypeptide binding]; other site
342109001079	oligomer interface [polypeptide binding]; other site
342109001080	active site residues [active]
342109001081	tropinone reductase; Provisional; Region: PRK09242
342109001082	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109001083	NAD(P) binding site [chemical binding]; other site
342109001084	active site
342109001085	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
342109001086	DNA topoisomerase I; Provisional; Region: PRK08780
342109001087	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363
342109001088	active site
342109001089	interdomain interaction site; other site
342109001090	putative metal-binding site [ion binding]; other site
342109001091	nucleotide binding site [chemical binding]; other site
342109001092	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
342109001093	domain I; other site
342109001094	DNA binding groove [nucleotide binding]
342109001095	phosphate binding site [ion binding]; other site
342109001096	domain II; other site
342109001097	domain III; other site
342109001098	nucleotide binding site [chemical binding]; other site
342109001099	catalytic site [active]
342109001100	domain IV; other site
342109001101	RDD family; Region: RDD; cl00746
342109001102	Pilin (bacterial filament); Region: Pilin; pfam00114
342109001103	Protein of unknown function (DUF494); Region: DUF494; cl01103
342109001104	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
342109001105	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
342109001106	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
342109001107	putative peptidoglycan binding site; other site
342109001108	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
342109001109	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
342109001110	active site
342109001111	catalytic residues [active]
342109001112	metal binding site [ion binding]; metal-binding site
342109001113	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
342109001114	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
342109001115	putative active site [active]
342109001116	substrate binding site [chemical binding]; other site
342109001117	putative cosubstrate binding site; other site
342109001118	catalytic site [active]
342109001119	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
342109001120	substrate binding site [chemical binding]; other site
342109001121	16S rRNA methyltransferase B; Provisional; Region: PRK10901
342109001122	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
342109001123	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109001124	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
342109001125	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961
342109001126	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
342109001127	O-Antigen ligase; Region: Wzy_C; cl04850
342109001128	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
342109001129	putative metal binding site [ion binding]; other site
342109001130	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
342109001131	Predicted membrane protein [Function unknown]; Region: COG3428
342109001132	Bacterial membrane flanked domain; Region: DUF304; cl01348
342109001133	Bacterial membrane flanked domain; Region: DUF304; cl01348
342109001134	Bacterial membrane flanked domain; Region: DUF304; cl01348
342109001135	Bacterial membrane flanked domain; Region: DUF304; cl01348
342109001136	GTP cyclohydrolase; Provisional; Region: PRK08815
342109001137	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
342109001138	dimerization interface [polypeptide binding]; other site
342109001139	active site
342109001140	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109001141	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
342109001142	putative acyl-acceptor binding pocket; other site
342109001143	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563
342109001144	putative active site [active]
342109001145	dimerization interface [polypeptide binding]; other site
342109001146	putative tRNAtyr binding site [nucleotide binding]; other site
342109001147	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
342109001148	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
342109001149	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
342109001150	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
342109001151	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342109001152	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
342109001153	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
342109001154	DNA binding residues [nucleotide binding]
342109001155	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
342109001156	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
342109001157	DNA binding site [nucleotide binding]
342109001158	Int/Topo IB signature motif; other site
342109001159	active site
342109001160	Parvovirus non-structural protein NS1; Region: Parvo_NS1; pfam01057
342109001161	Integrase core domain; Region: rve; cl01316
342109001162	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109001163	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109001164	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109001165	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109001166	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109001167	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
342109001168	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
342109001169	Walker A/P-loop; other site
342109001170	ATP binding site [chemical binding]; other site
342109001171	Q-loop/lid; other site
342109001172	ABC transporter signature motif; other site
342109001173	Walker B; other site
342109001174	D-loop; other site
342109001175	H-loop/switch region; other site
342109001176	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
342109001177	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
342109001178	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
342109001179	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109001180	N-terminal plug; other site
342109001181	ligand-binding site [chemical binding]; other site
342109001182	Protein of unknown function (DUF2894); Region: DUF2894; pfam11445
342109001183	hypothetical protein; Provisional; Region: PRK09040
342109001184	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
342109001185	ligand binding site [chemical binding]; other site
342109001186	Domain of unknown function (DUF802); Region: DUF802; pfam05650
342109001187	Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
342109001188	Flagellin N-methylase; Region: FliB; cl00497
342109001189	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
342109001190	NAD(P) binding site [chemical binding]; other site
342109001191	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109001192	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109001193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109001194	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
342109001195	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
342109001196	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
342109001197	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
342109001198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109001199	active site
342109001200	phosphorylation site [posttranslational modification]
342109001201	intermolecular recognition site; other site
342109001202	dimerization interface [polypeptide binding]; other site
342109001203	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109001204	Walker A motif; other site
342109001205	ATP binding site [chemical binding]; other site
342109001206	Walker B motif; other site
342109001207	arginine finger; other site
342109001208	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
342109001209	CheB methylesterase; Region: CheB_methylest; pfam01339
342109001210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109001211	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
342109001212	FAD dependent oxidoreductase; Region: DAO; pfam01266
342109001213	Histidine kinase; Region: His_kinase; pfam06580
342109001214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
342109001215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109001216	active site
342109001217	phosphorylation site [posttranslational modification]
342109001218	intermolecular recognition site; other site
342109001219	dimerization interface [polypeptide binding]; other site
342109001220	LytTr DNA-binding domain; Region: LytTR; cl04498
342109001221	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
342109001222	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
342109001223	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
342109001224	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
342109001225	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
342109001226	active site
342109001227	Zn binding site [ion binding]; other site
342109001228	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
342109001229	active site
342109001230	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
342109001231	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
342109001232	active site
342109001233	catalytic tetrad [active]
342109001234	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
342109001235	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
342109001236	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
342109001237	putative active site [active]
342109001238	metal binding site [ion binding]; metal-binding site
342109001239	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
342109001240	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
342109001241	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
342109001242	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
342109001243	Fasciclin domain; Region: Fasciclin; cl02663
342109001244	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
342109001245	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
342109001246	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
342109001247	Walker A/P-loop; other site
342109001248	ATP binding site [chemical binding]; other site
342109001249	Q-loop/lid; other site
342109001250	ABC transporter signature motif; other site
342109001251	Walker B; other site
342109001252	D-loop; other site
342109001253	H-loop/switch region; other site
342109001254	ABC-2 type transporter; Region: ABC2_membrane; cl11417
342109001255	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
342109001256	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
342109001257	active site
342109001258	catalytic triad [active]
342109001259	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
342109001260	YadA-like C-terminal region; Region: YadA; pfam03895
342109001261	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109001262	dimer interface [polypeptide binding]; other site
342109001263	phosphorylation site [posttranslational modification]
342109001264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109001265	ATP binding site [chemical binding]; other site
342109001266	Mg2+ binding site [ion binding]; other site
342109001267	G-X-G motif; other site
342109001268	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
342109001269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109001270	active site
342109001271	phosphorylation site [posttranslational modification]
342109001272	intermolecular recognition site; other site
342109001273	dimerization interface [polypeptide binding]; other site
342109001274	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209
342109001275	DNA binding site [nucleotide binding]
342109001276	flagellar motor protein MotB; Validated; Region: motB; PRK09041
342109001277	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
342109001278	ligand binding site [chemical binding]; other site
342109001279	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
342109001280	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
342109001281	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
342109001282	SelR domain; Region: SelR; cl00369
342109001283	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
342109001284	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109001285	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
342109001286	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
342109001287	alanine racemase; Reviewed; Region: alr; PRK00053
342109001288	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
342109001289	active site
342109001290	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
342109001291	substrate binding site [chemical binding]; other site
342109001292	catalytic residues [active]
342109001293	dimer interface [polypeptide binding]; other site
342109001294	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
342109001295	PAS domain S-box; Region: sensory_box; TIGR00229
342109001296	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
342109001297	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342109001298	putative active site [active]
342109001299	heme pocket [chemical binding]; other site
342109001300	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109001301	dimer interface [polypeptide binding]; other site
342109001302	phosphorylation site [posttranslational modification]
342109001303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109001304	ATP binding site [chemical binding]; other site
342109001305	Mg2+ binding site [ion binding]; other site
342109001306	G-X-G motif; other site
342109001307	Response regulator receiver domain; Region: Response_reg; pfam00072
342109001308	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109001309	active site
342109001310	phosphorylation site [posttranslational modification]
342109001311	intermolecular recognition site; other site
342109001312	dimerization interface [polypeptide binding]; other site
342109001313	Protein of unknown function (DUF3247); Region: DUF3247; pfam11607
342109001314	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
342109001315	Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303
342109001316	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
342109001317	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109001318	S-adenosylmethionine binding site [chemical binding]; other site
342109001319	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
342109001320	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
342109001321	active site
342109001322	uracil binding [chemical binding]; other site
342109001323	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
342109001324	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
342109001325	motif II; other site
342109001326	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109001327	oxidoreductase; Validated; Region: PRK05717
342109001328	NAD(P) binding site [chemical binding]; other site
342109001329	active site
342109001330	Protein of unknown function (DUF1415); Region: DUF1415; cl01301
342109001331	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
342109001332	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
342109001333	Protein of unknown function (DUF520); Region: DUF520; cl00723
342109001334	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
342109001335	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258
342109001336	Walker A/P-loop; other site
342109001337	ATP binding site [chemical binding]; other site
342109001338	Q-loop/lid; other site
342109001339	ABC transporter signature motif; other site
342109001340	Walker B; other site
342109001341	D-loop; other site
342109001342	H-loop/switch region; other site
342109001343	NIL domain; Region: NIL; pfam09383
342109001344	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
342109001345	dimer interface [polypeptide binding]; other site
342109001346	conserved gate region; other site
342109001347	ABC-ATPase subunit interface; other site
342109001348	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109001349	Surface antigen; Region: Surface_Ag_2; cl01155
342109001350	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
342109001351	Protein of unknown function (DUF2884); Region: DUF2884; cl08135
342109001352	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
342109001353	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
342109001354	E3 interaction surface; other site
342109001355	lipoyl attachment site [posttranslational modification]; other site
342109001356	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
342109001357	E3 interaction surface; other site
342109001358	lipoyl attachment site [posttranslational modification]; other site
342109001359	e3 binding domain; Region: E3_binding; pfam02817
342109001360	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
342109001361	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
342109001362	E3 interaction surface; other site
342109001363	lipoyl attachment site [posttranslational modification]; other site
342109001364	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109001365	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
342109001366	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109001367	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
342109001368	ATP synthase A chain; Region: ATP-synt_A; cl00413
342109001369	ATP synthase subunit C; Region: ATP-synt_C; cl00466
342109001370	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
342109001371	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
342109001372	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
342109001373	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
342109001374	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
342109001375	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
342109001376	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
342109001377	beta subunit interaction interface [polypeptide binding]; other site
342109001378	Walker A motif; other site
342109001379	ATP binding site [chemical binding]; other site
342109001380	Walker B motif; other site
342109001381	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
342109001382	ATP synthase; Region: ATP-synt; cl00365
342109001383	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
342109001384	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
342109001385	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
342109001386	alpha subunit interaction interface [polypeptide binding]; other site
342109001387	Walker A motif; other site
342109001388	ATP binding site [chemical binding]; other site
342109001389	Walker B motif; other site
342109001390	inhibitor binding site; inhibition site
342109001391	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
342109001392	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
342109001393	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
342109001394	Chorismate mutase type II; Region: CM_2; cl00693
342109001395	GtrA-like protein; Region: GtrA; cl00971
342109001396	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
342109001397	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
342109001398	Substrate binding site [chemical binding]; other site
342109001399	Mg++ binding site [ion binding]; other site
342109001400	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
342109001401	active site
342109001402	substrate binding site [chemical binding]; other site
342109001403	CoA binding site [chemical binding]; other site
342109001404	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109001405	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109001406	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109001407	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109001408	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
342109001409	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
342109001410	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714
342109001411	glutaminase active site [active]
342109001412	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
342109001413	dimer interface [polypeptide binding]; other site
342109001414	active site
342109001415	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
342109001416	dimer interface [polypeptide binding]; other site
342109001417	active site
342109001418	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109001419	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109001420	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109001421	Integrase core domain; Region: rve; cl01316
342109001422	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
342109001423	dimer interface [polypeptide binding]; other site
342109001424	active site
342109001425	metal binding site [ion binding]; metal-binding site
342109001426	glutathione binding site [chemical binding]; other site
342109001427	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
342109001428	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
342109001429	Multicopper oxidase; Region: Cu-oxidase; cl14658
342109001430	Multicopper oxidase; Region: Cu-oxidase; cl14658
342109001431	Multicopper oxidase; Region: Cu-oxidase; cl14658
342109001432	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
342109001433	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
342109001434	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109001435	catalytic residue [active]
342109001436	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
342109001437	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
342109001438	active site
342109001439	Zn binding site [ion binding]; other site
342109001440	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
342109001441	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
342109001442	dimer interface [polypeptide binding]; other site
342109001443	active site
342109001444	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
342109001445	dimer interface [polypeptide binding]; other site
342109001446	active site 1 [active]
342109001447	active site 2 [active]
342109001448	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
342109001449	active site
342109001450	DNA polymerase IV; Validated; Region: PRK02406
342109001451	DNA binding site [nucleotide binding]
342109001452	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
342109001453	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
342109001454	motif II; other site
342109001455	TfoX N-terminal domain; Region: TfoX_N; cl01167
342109001456	GAF domain; Region: GAF; cl00853
342109001457	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
342109001458	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
342109001459	active site
342109001460	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
342109001461	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
342109001462	ATP binding site [chemical binding]; other site
342109001463	Mg++ binding site [ion binding]; other site
342109001464	motif III; other site
342109001465	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109001466	nucleotide binding region [chemical binding]; other site
342109001467	ATP-binding site [chemical binding]; other site
342109001468	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
342109001469	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
342109001470	maleylacetoacetate isomerase; Region: maiA; TIGR01262
342109001471	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042
342109001472	C-terminal domain interface [polypeptide binding]; other site
342109001473	GSH binding site (G-site) [chemical binding]; other site
342109001474	putative dimer interface [polypeptide binding]; other site
342109001475	GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191
342109001476	dimer interface [polypeptide binding]; other site
342109001477	N-terminal domain interface [polypeptide binding]; other site
342109001478	putative maleylacetoacetate (MAA) substrate binding site (H site); other site
342109001479	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
342109001480	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109001481	ATP binding site [chemical binding]; other site
342109001482	Walker B motif; other site
342109001483	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
342109001484	Protein of unknown function (DUF465); Region: DUF465; cl01070
342109001485	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
342109001486	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
342109001487	dimer interface [polypeptide binding]; other site
342109001488	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109001489	catalytic residue [active]
342109001490	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as...; Region: CBS_pair_PALP_assoc2; cd04609
342109001491	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
342109001492	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
342109001493	homodimer interface [polypeptide binding]; other site
342109001494	substrate-cofactor binding pocket; other site
342109001495	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109001496	catalytic residue [active]
342109001497	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109001498	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
342109001499	extended (e) SDRs; Region: SDR_e; cd08946
342109001500	NAD(P) binding site [chemical binding]; other site
342109001501	active site
342109001502	substrate binding site [chemical binding]; other site
342109001503	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
342109001504	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
342109001505	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
342109001506	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109001507	Transposase, Mutator family; Region: Transposase_mut; pfam00872
342109001508	MULE transposase domain; Region: MULE; pfam10551
342109001509	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
342109001510	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220
342109001511	Walker A/P-loop; other site
342109001512	ATP binding site [chemical binding]; other site
342109001513	Q-loop/lid; other site
342109001514	ABC transporter signature motif; other site
342109001515	Walker B; other site
342109001516	D-loop; other site
342109001517	H-loop/switch region; other site
342109001518	ABC-2 type transporter; Region: ABC2_membrane; cl11417
342109001519	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
342109001520	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
342109001521	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
342109001522	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
342109001523	Ligand binding site [chemical binding]; other site
342109001524	dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181
342109001525	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
342109001526	NAD binding site [chemical binding]; other site
342109001527	substrate binding site [chemical binding]; other site
342109001528	homodimer interface [polypeptide binding]; other site
342109001529	active site
342109001530	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
342109001531	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
342109001532	substrate binding site [chemical binding]; other site
342109001533	tetramer interface [polypeptide binding]; other site
342109001534	Cupin domain; Region: Cupin_2; cl09118
342109001535	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
342109001536	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
342109001537	NADP binding site [chemical binding]; other site
342109001538	active site
342109001539	putative substrate binding site [chemical binding]; other site
342109001540	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
342109001541	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
342109001542	Substrate binding site [chemical binding]; other site
342109001543	Cupin domain; Region: Cupin_2; cl09118
342109001544	phosphomannomutase CpsG; Provisional; Region: PRK15414
342109001545	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
342109001546	active site
342109001547	substrate binding site [chemical binding]; other site
342109001548	metal binding site [ion binding]; metal-binding site
342109001549	Coenzyme A transferase; Region: CoA_trans; cl00773
342109001550	Coenzyme A transferase; Region: CoA_trans; cl00773
342109001551	Rhamnan synthesis protein F; Region: RgpF; cl01529
342109001552	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
342109001553	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109001554	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
342109001555	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
342109001556	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
342109001557	Protein of unknown function (DUF330); Region: DUF330; cl01135
342109001558	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
342109001559	mce related protein; Region: MCE; cl03606
342109001560	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
342109001561	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109001562	Walker A/P-loop; other site
342109001563	ATP binding site [chemical binding]; other site
342109001564	Q-loop/lid; other site
342109001565	ABC transporter signature motif; other site
342109001566	Walker B; other site
342109001567	D-loop; other site
342109001568	H-loop/switch region; other site
342109001569	Domain of unknown function DUF140; Region: DUF140; cl00510
342109001570	Uncharacterized conserved protein [Function unknown]; Region: COG2966
342109001571	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
342109001572	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
342109001573	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
342109001574	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
342109001575	prolyl-tRNA synthetase; Provisional; Region: PRK09194
342109001576	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779
342109001577	dimer interface [polypeptide binding]; other site
342109001578	motif 1; other site
342109001579	active site
342109001580	motif 2; other site
342109001581	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334
342109001582	putative deacylase active site [active]
342109001583	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
342109001584	active site
342109001585	motif 3; other site
342109001586	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861
342109001587	anticodon binding site; other site
342109001588	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
342109001589	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
342109001590	DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436
342109001591	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
342109001592	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342109001593	Coenzyme A binding pocket [chemical binding]; other site
342109001594	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109001595	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109001596	Transposase domain (DUF772); Region: DUF772; cl12084
342109001597	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109001598	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109001599	lytic murein transglycosylase; Provisional; Region: PRK11619
342109001600	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
342109001601	N-acetyl-D-glucosamine binding site [chemical binding]; other site
342109001602	catalytic residue [active]
342109001603	Pectate lyase; Region: Pec_lyase_C; cl01593
342109001604	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109001605	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109001606	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109001607	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109001608	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109001609	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109001610	putative transposase OrfB; Reviewed; Region: PHA02517
342109001611	Integrase core domain; Region: rve; cl01316
342109001612	Transposase domain (DUF772); Region: DUF772; cl12084
342109001613	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
342109001614	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
342109001615	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
342109001616	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
342109001617	active site
342109001618	HIGH motif; other site
342109001619	nucleotide binding site [chemical binding]; other site
342109001620	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
342109001621	active site
342109001622	KMSKS motif; other site
342109001623	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
342109001624	tRNA binding surface [nucleotide binding]; other site
342109001625	anticodon binding site; other site
342109001626	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
342109001627	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
342109001628	multifunctional aminopeptidase A; Provisional; Region: PRK00913
342109001629	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433
342109001630	interface (dimer of trimers) [polypeptide binding]; other site
342109001631	Substrate-binding/catalytic site; other site
342109001632	Zn-binding sites [ion binding]; other site
342109001633	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
342109001634	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
342109001635	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
342109001636	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
342109001637	RDD family; Region: RDD; cl00746
342109001638	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
342109001639	N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798
342109001640	Int/Topo IB signature motif; other site
342109001641	active site
342109001642	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020
342109001643	dimerization domain [polypeptide binding]; other site
342109001644	dimer interface [polypeptide binding]; other site
342109001645	catalytic residues [active]
342109001646	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
342109001647	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal...; Region: PurM-like; cl10019
342109001648	dimerization interface [polypeptide binding]; other site
342109001649	ATP binding site [chemical binding]; other site
342109001650	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204
342109001651	dimerization interface [polypeptide binding]; other site
342109001652	ATP binding site [chemical binding]; other site
342109001653	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
342109001654	putative active site [active]
342109001655	catalytic triad [active]
342109001656	YadA-like C-terminal region; Region: YadA; pfam03895
342109001657	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
342109001658	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109001659	Integrase core domain; Region: rve; cl01316
342109001660	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
342109001661	GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
342109001662	general secretory pathway protein E; Region: type_II_gspE; TIGR02533
342109001663	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
342109001664	Walker A motif; other site
342109001665	ATP binding site [chemical binding]; other site
342109001666	Walker B motif; other site
342109001667	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
342109001668	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
342109001669	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
342109001670	Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334
342109001671	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
342109001672	general secretion pathway protein J; Validated; Region: PRK08808
342109001673	General secretion pathway protein K; Region: GspK; pfam03934
342109001674	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
342109001675	General secretion pathway protein M; Region: GspM_II; pfam10741
342109001676	general secretion pathway protein D; Region: type_II_gspD; TIGR02517
342109001677	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
342109001678	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
342109001679	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
342109001680	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
342109001681	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
342109001682	transcriptional regulator protein; Region: phnR; TIGR03337
342109001683	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
342109001684	DNA-binding site [nucleotide binding]; DNA binding site
342109001685	UTRA domain; Region: UTRA; cl06649
342109001686	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
342109001687	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
342109001688	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109001689	N-terminal plug; other site
342109001690	ligand-binding site [chemical binding]; other site
342109001691	Phosphotransferase enzyme family; Region: APH; pfam01636
342109001692	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
342109001693	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
342109001694	Probable Catalytic site [active]
342109001695	metal binding site [ion binding]; metal-binding site
342109001696	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109001697	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
342109001698	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
342109001699	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
342109001700	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689
342109001701	CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863
342109001702	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
342109001703	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
342109001704	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
342109001705	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
342109001706	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
342109001707	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
342109001708	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109001709	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109001710	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
342109001711	active site
342109001712	dimer interface [polypeptide binding]; other site
342109001713	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
342109001714	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
342109001715	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
342109001716	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
342109001717	dimer interface [polypeptide binding]; other site
342109001718	active site
342109001719	CoA binding pocket [chemical binding]; other site
342109001720	MEKHLA domain; Region: MEKHLA; pfam08670
342109001721	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
342109001722	putative active site [active]
342109001723	heme pocket [chemical binding]; other site
342109001724	Acyl transferase domain; Region: Acyl_transf_1; cl08282
342109001725	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
342109001726	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
342109001727	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
342109001728	NAD(P) binding site [chemical binding]; other site
342109001729	homotetramer interface [polypeptide binding]; other site
342109001730	homodimer interface [polypeptide binding]; other site
342109001731	active site
342109001732	Phosphopantetheine attachment site; Region: PP-binding; cl09936
342109001733	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
342109001734	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
342109001735	dimer interface [polypeptide binding]; other site
342109001736	active site
342109001737	hypothetical protein; Validated; Region: PRK09070
342109001738	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
342109001739	chorismate binding enzyme; Region: Chorismate_bind; cl10555
342109001740	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
342109001741	dimerization interface [polypeptide binding]; other site
342109001742	DNA polymerase III subunit delta'; Validated; Region: PRK08769
342109001743	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109001744	PilZ domain; Region: PilZ; cl01260
342109001745	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109001746	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
342109001747	Propionate catabolism activator; Region: PrpR_N; pfam06506
342109001748	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109001749	Walker A motif; other site
342109001750	ATP binding site [chemical binding]; other site
342109001751	Walker B motif; other site
342109001752	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
342109001753	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
342109001754	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
342109001755	tetramer interface [polypeptide binding]; other site
342109001756	active site
342109001757	Mg2+/Mn2+ binding site [ion binding]; other site
342109001758	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
342109001759	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (...; Region: Ec2MCS_like_1; cd06117
342109001760	dimer interface [polypeptide binding]; other site
342109001761	active site
342109001762	citrylCoA binding site [chemical binding]; other site
342109001763	oxalacetate/citrate binding site [chemical binding]; other site
342109001764	coenzyme A binding site [chemical binding]; other site
342109001765	catalytic triad [active]
342109001766	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
342109001767	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
342109001768	substrate binding site [chemical binding]; other site
342109001769	ligand binding site [chemical binding]; other site
342109001770	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
342109001771	substrate binding site [chemical binding]; other site
342109001772	Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448
342109001773	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
342109001774	Transposase domain (DUF772); Region: DUF772; cl12084
342109001775	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109001776	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
342109001777	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109001778	N-terminal plug; other site
342109001779	ligand-binding site [chemical binding]; other site
342109001780	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
342109001781	active site
342109001782	Transposase IS200 like; Region: Y1_Tnp; cl00848
342109001783	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109001784	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109001785	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109001786	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
342109001787	putative active site [active]
342109001788	catalytic site [active]
342109001789	putative metal binding site [ion binding]; other site
342109001790	oligomer interface [polypeptide binding]; other site
342109001791	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109001792	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109001793	Integrase core domain; Region: rve; cl01316
342109001794	Ferritin-like domain; Region: Ferritin; pfam00210
342109001795	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
342109001796	dinuclear metal binding motif [ion binding]; other site
342109001797	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
342109001798	catalytic triad [active]
342109001799	dimer interface [polypeptide binding]; other site
342109001800	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464
342109001801	putative dimer interface [polypeptide binding]; other site
342109001802	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
342109001803	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
342109001804	HSP70 interaction site [polypeptide binding]; other site
342109001805	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
342109001806	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
342109001807	Response regulator receiver domain; Region: Response_reg; pfam00072
342109001808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109001809	active site
342109001810	phosphorylation site [posttranslational modification]
342109001811	intermolecular recognition site; other site
342109001812	dimerization interface [polypeptide binding]; other site
342109001813	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
342109001814	HflK protein; Region: hflK; TIGR01933
342109001815	FtsH protease regulator HflC; Provisional; Region: PRK11029
342109001816	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
342109001817	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275
342109001818	adenylosuccinate synthetase; Provisional; Region: PRK01117
342109001819	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108
342109001820	GDP-binding site [chemical binding]; other site
342109001821	ACT binding site; other site
342109001822	IMP binding site; other site
342109001823	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
342109001824	Zn binding site [ion binding]; other site
342109001825	Transposase domain (DUF772); Region: DUF772; cl12084
342109001826	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109001827	Zinc-finger domain; Region: zf-CHCC; cl01821
342109001828	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
342109001829	putative ADP-binding pocket [chemical binding]; other site
342109001830	O-Antigen ligase; Region: Wzy_C; cl04850
342109001831	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
342109001832	putative acyl-acceptor binding pocket; other site
342109001833	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
342109001834	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
342109001835	Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012
342109001836	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
342109001837	Outer membrane efflux protein; Region: OEP; pfam02321
342109001838	Outer membrane efflux protein; Region: OEP; pfam02321
342109001839	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109001840	S-adenosylmethionine binding site [chemical binding]; other site
342109001841	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342109001842	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342109001843	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
342109001844	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109001845	metal binding site [ion binding]; metal-binding site
342109001846	active site
342109001847	I-site; other site
342109001848	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
342109001849	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109001850	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
342109001851	dimerization interface [polypeptide binding]; other site
342109001852	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
342109001853	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
342109001854	substrate binding site [chemical binding]; other site
342109001855	ligand binding site [chemical binding]; other site
342109001856	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577
342109001857	substrate binding site [chemical binding]; other site
342109001858	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109001859	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
342109001860	isocitrate dehydrogenase; Validated; Region: PRK06451
342109001861	2-isopropylmalate synthase; Validated; Region: PRK00915
342109001862	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
342109001863	active site
342109001864	catalytic residues [active]
342109001865	metal binding site [ion binding]; metal-binding site
342109001866	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
342109001867	hypothetical protein; Provisional; Region: PRK06815
342109001868	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
342109001869	tetramer interface [polypeptide binding]; other site
342109001870	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109001871	catalytic residue [active]
342109001872	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
342109001873	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
342109001874	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
342109001875	PYR/PP interface [polypeptide binding]; other site
342109001876	dimer interface [polypeptide binding]; other site
342109001877	TPP binding site [chemical binding]; other site
342109001878	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
342109001879	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
342109001880	TPP-binding site [chemical binding]; other site
342109001881	dimer interface [polypeptide binding]; other site
342109001882	ketol-acid reductoisomerase; Provisional; Region: PRK05479
342109001883	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109001884	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
342109001885	ThiC family; Region: ThiC; cl08031
342109001886	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109001887	DNA binding site [nucleotide binding]
342109001888	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
342109001889	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
342109001890	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
342109001891	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109001892	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109001893	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109001894	active site
342109001895	phosphorylation site [posttranslational modification]
342109001896	intermolecular recognition site; other site
342109001897	dimerization interface [polypeptide binding]; other site
342109001898	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
342109001899	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
342109001900	dimer interface [polypeptide binding]; other site
342109001901	substrate binding site [chemical binding]; other site
342109001902	metal binding sites [ion binding]; metal-binding site
342109001903	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
342109001904	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109001905	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109001906	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109001907	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
342109001908	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
342109001909	active site
342109001910	ADP/pyrophosphate binding site [chemical binding]; other site
342109001911	dimerization interface [polypeptide binding]; other site
342109001912	allosteric effector site; other site
342109001913	fructose-1,6-bisphosphate binding site; other site
342109001914	adenylate kinase; Reviewed; Region: adk; PRK00279
342109001915	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
342109001916	AMP-binding site [chemical binding]; other site
342109001917	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
342109001918	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
342109001919	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
342109001920	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
342109001921	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
342109001922	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
342109001923	Found in ATP-dependent protease La (LON); Region: LON; cl01056
342109001924	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
342109001925	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109001926	glutathionine S-transferase; Provisional; Region: PRK10542
342109001927	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057
342109001928	C-terminal domain interface [polypeptide binding]; other site
342109001929	GSH binding site (G-site) [chemical binding]; other site
342109001930	dimer interface [polypeptide binding]; other site
342109001931	GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188
342109001932	dimer interface [polypeptide binding]; other site
342109001933	N-terminal domain interface [polypeptide binding]; other site
342109001934	substrate binding pocket (H-site) [chemical binding]; other site
342109001935	malate dehydrogenase; Provisional; Region: PRK05442
342109001936	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
342109001937	NAD(P) binding site [chemical binding]; other site
342109001938	dimer interface [polypeptide binding]; other site
342109001939	malate binding site [chemical binding]; other site
342109001940	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
342109001941	active site
342109001942	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
342109001943	TypA (tyrosine phosphorylated protein A)/BipA subfamily.  BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants.  BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891
342109001944	G1 box; other site
342109001945	putative GEF interaction site [polypeptide binding]; other site
342109001946	GTP/Mg2+ binding site [chemical binding]; other site
342109001947	Switch I region; other site
342109001948	G2 box; other site
342109001949	G3 box; other site
342109001950	Switch II region; other site
342109001951	G4 box; other site
342109001952	G5 box; other site
342109001953	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
342109001954	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a...; Region: BipA_TypA_C; cd03710
342109001955	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
342109001956	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
342109001957	Mechanosensitive ion channel; Region: MS_channel; pfam00924
342109001958	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
342109001959	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
342109001960	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109001961	N-terminal plug; other site
342109001962	ligand-binding site [chemical binding]; other site
342109001963	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
342109001964	Transposase domain (DUF772); Region: DUF772; cl12084
342109001965	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109001966	putative transposase OrfB; Reviewed; Region: PHA02517
342109001967	Integrase core domain; Region: rve; cl01316
342109001968	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109001969	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109001970	Integrase core domain; Region: rve; cl01316
342109001971	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109001972	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109001973	Integrase core domain; Region: rve; cl01316
342109001974	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109001975	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109001976	Integrase core domain; Region: rve; cl01316
342109001977	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109001978	Integrase core domain; Region: rve; cl01316
342109001979	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
342109001980	active site
342109001981	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109001982	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109001983	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109001984	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109001985	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109001986	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109001987	Transposase domain (DUF772); Region: DUF772; cl12084
342109001988	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109001989	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
342109001990	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
342109001991	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109001992	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
342109001993	putative active site [active]
342109001994	catalytic site [active]
342109001995	putative metal binding site [ion binding]; other site
342109001996	oligomer interface [polypeptide binding]; other site
342109001997	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109001998	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109001999	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002000	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002001	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109002002	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109002003	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
342109002004	BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473
342109002005	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109002006	Integrase core domain; Region: rve; cl01316
342109002007	trigger factor; Provisional; Region: tig; PRK01490
342109002008	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
342109002009	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
342109002010	oligomer interface [polypeptide binding]; other site
342109002011	active site residues [active]
342109002012	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
342109002013	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
342109002014	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109002015	Walker A motif; other site
342109002016	ATP binding site [chemical binding]; other site
342109002017	Walker B motif; other site
342109002018	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
342109002019	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
342109002020	Found in ATP-dependent protease La (LON); Region: LON; cl01056
342109002021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109002022	Walker A motif; other site
342109002023	ATP binding site [chemical binding]; other site
342109002024	Walker B motif; other site
342109002025	arginine finger; other site
342109002026	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
342109002027	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
342109002028	IHF dimer interface [polypeptide binding]; other site
342109002029	IHF - DNA interface [nucleotide binding]; other site
342109002030	periplasmic folding chaperone; Provisional; Region: PRK10788
342109002031	PPIC-type PPIASE domain; Region: Rotamase; cl08278
342109002032	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
342109002033	N-acetyl-D-glucosamine binding site [chemical binding]; other site
342109002034	catalytic residue [active]
342109002035	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
342109002036	putative peptidoglycan binding site; other site
342109002037	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
342109002038	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
342109002039	RNA/DNA hybrid binding site [nucleotide binding]; other site
342109002040	active site
342109002041	Proteobacterial; Region: dnaQ_proteo; TIGR01406
342109002042	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
342109002043	active site
342109002044	substrate binding site [chemical binding]; other site
342109002045	catalytic site [active]
342109002046	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
342109002047	Protein phosphatase 2C; Region: PP2C; pfam00481
342109002048	Active site [active]
342109002049	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408
342109002050	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109002051	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109002052	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109002053	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
342109002054	Protein of unknown function (DUF3274); Region: DUF3274; pfam11678
342109002055	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
342109002056	Protein of unknown function (DUF2875); Region: DUF2875; pfam11394
342109002057	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
342109002058	Protein of unknown function (DUF3274); Region: DUF3274; pfam11678
342109002059	Protein of unknown function (DUF2875); Region: DUF2875; pfam11394
342109002060	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109002061	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109002062	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
342109002063	Phage integrase family; Region: Phage_integrase; pfam00589
342109002064	DNA binding site [nucleotide binding]
342109002065	Int/Topo IB signature motif; other site
342109002066	active site
342109002067	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
342109002068	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
342109002069	putative active site [active]
342109002070	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
342109002071	ATP binding site [chemical binding]; other site
342109002072	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
342109002073	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
342109002074	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
342109002075	FeS/SAM binding site; other site
342109002076	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
342109002077	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
342109002078	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420
342109002079	trimer interface [polypeptide binding]; other site
342109002080	dimer interface [polypeptide binding]; other site
342109002081	putative active site [active]
342109002082	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
342109002083	MoaE interaction surface [polypeptide binding]; other site
342109002084	MoeB interaction surface [polypeptide binding]; other site
342109002085	thiocarboxylated glycine; other site
342109002086	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
342109002087	MoaE homodimer interface [polypeptide binding]; other site
342109002088	MoaD interaction [polypeptide binding]; other site
342109002089	active site residues [active]
342109002090	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
342109002091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109002092	Walker A motif; other site
342109002093	ATP binding site [chemical binding]; other site
342109002094	Walker B motif; other site
342109002095	arginine finger; other site
342109002096	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
342109002097	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
342109002098	Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494
342109002099	recombination protein RecR; Reviewed; Region: recR; PRK00076
342109002100	RecR protein; Region: RecR; pfam02132
342109002101	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
342109002102	putative active site [active]
342109002103	putative metal-binding site [ion binding]; other site
342109002104	tetramer interface [polypeptide binding]; other site
342109002105	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
342109002106	nucleotide binding site/active site [active]
342109002107	HIT family signature motif; other site
342109002108	catalytic residue [active]
342109002109	Outer membrane lipoprotein Slp family; Region: Slp; cl01164
342109002110	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
342109002111	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
342109002112	Protein of unknown function DUF58; Region: DUF58; pfam01882
342109002113	MoxR-like ATPases [General function prediction only]; Region: COG0714
342109002114	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109002115	Walker A motif; other site
342109002116	ATP binding site [chemical binding]; other site
342109002117	Walker B motif; other site
342109002118	arginine finger; other site
342109002119	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961
342109002120	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
342109002121	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
342109002122	active site
342109002123	catalytic residues [active]
342109002124	metal binding site [ion binding]; metal-binding site
342109002125	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302
342109002126	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302
342109002127	Rhamnogalacturonase B, N-terminal; Region: RhgB_N; pfam09284
342109002128	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109002129	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109002130	Transposase domain (DUF772); Region: DUF772; cl12084
342109002131	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109002132	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
342109002133	ADP-ribose binding site [chemical binding]; other site
342109002134	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109002135	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
342109002136	putative GSH binding site [chemical binding]; other site
342109002137	catalytic residues [active]
342109002138	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
342109002139	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
342109002140	active site residue [active]
342109002141	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
342109002142	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109002143	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
342109002144	active site
342109002145	catalytic triad [active]
342109002146	oxyanion hole [active]
342109002147	tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264
342109002148	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342109002149	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109002150	homodimer interface [polypeptide binding]; other site
342109002151	catalytic residue [active]
342109002152	GTPase RsgA; Reviewed; Region: PRK01889
342109002153	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
342109002154	GTPase/OB domain interface [polypeptide binding]; other site
342109002155	GTPase/Zn-binding domain interface [polypeptide binding]; other site
342109002156	GTP/Mg2+ binding site [chemical binding]; other site
342109002157	G4 box; other site
342109002158	G5 box; other site
342109002159	G1 box; other site
342109002160	Switch I region; other site
342109002161	G2 box; other site
342109002162	G3 box; other site
342109002163	Switch II region; other site
342109002164	conserved hypothetical protein; Region: QEGLA; TIGR02421
342109002165	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
342109002166	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
342109002167	potential catalytic triad [active]
342109002168	conserved cys residue [active]
342109002169	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
342109002170	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109002171	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109002172	GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301
342109002173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109002174	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342109002175	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342109002176	DNA binding site [nucleotide binding]
342109002177	domain linker motif; other site
342109002178	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
342109002179	putative dimerization interface [polypeptide binding]; other site
342109002180	putative ligand binding site [chemical binding]; other site
342109002181	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
342109002182	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109002183	NAD(P) binding site [chemical binding]; other site
342109002184	active site
342109002185	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
342109002186	Citrate transporter; Region: CitMHS; pfam03600
342109002187	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
342109002188	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
342109002189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109002190	active site
342109002191	phosphorylation site [posttranslational modification]
342109002192	intermolecular recognition site; other site
342109002193	dimerization interface [polypeptide binding]; other site
342109002194	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109002195	DNA binding site [nucleotide binding]
342109002196	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
342109002197	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
342109002198	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109002199	ATP binding site [chemical binding]; other site
342109002200	Mg2+ binding site [ion binding]; other site
342109002201	G-X-G motif; other site
342109002202	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109002203	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
342109002204	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109002205	active site
342109002206	phosphorylation site [posttranslational modification]
342109002207	intermolecular recognition site; other site
342109002208	dimerization interface [polypeptide binding]; other site
342109002209	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
342109002210	DNA binding residues [nucleotide binding]
342109002211	dimerization interface [polypeptide binding]; other site
342109002212	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
342109002213	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cl00470
342109002214	catalytic tetrad [active]
342109002215	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cl00470
342109002216	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342109002217	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109002218	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
342109002219	putative dimerization interface [polypeptide binding]; other site
342109002220	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109002221	citrate-proton symporter; Provisional; Region: PRK15075
342109002222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109002223	putative substrate translocation pore; other site
342109002224	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
342109002225	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
342109002226	PAS fold; Region: PAS_7; pfam12860
342109002227	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
342109002228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109002229	ATP binding site [chemical binding]; other site
342109002230	Mg2+ binding site [ion binding]; other site
342109002231	G-X-G motif; other site
342109002232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109002233	Response regulator receiver domain; Region: Response_reg; pfam00072
342109002234	active site
342109002235	phosphorylation site [posttranslational modification]
342109002236	intermolecular recognition site; other site
342109002237	dimerization interface [polypeptide binding]; other site
342109002238	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
342109002239	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
342109002240	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
342109002241	Malic enzyme, N-terminal domain; Region: malic; pfam00390
342109002242	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
342109002243	putative NAD(P) binding site [chemical binding]; other site
342109002244	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
342109002245	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109002246	putative transposase OrfB; Reviewed; Region: PHA02517
342109002247	Integrase core domain; Region: rve; cl01316
342109002248	Integrase core domain; Region: rve; cl01316
342109002249	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564
342109002250	thiamine phosphate binding site [chemical binding]; other site
342109002251	active site
342109002252	pyrophosphate binding site [ion binding]; other site
342109002253	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730
342109002254	Rubredoxin; Region: Rubredoxin; pfam00301
342109002255	iron binding site [ion binding]; other site
342109002256	Uncharacterized conserved protein [Function unknown]; Region: COG2912
342109002257	hypothetical protein; Provisional; Region: PRK10941
342109002258	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
342109002259	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
342109002260	tetramer (dimer of dimers) interface [polypeptide binding]; other site
342109002261	active site
342109002262	dimer interface [polypeptide binding]; other site
342109002263	EVE domain; Region: EVE; cl00728
342109002264	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
342109002265	Cell division protein ZapA; Region: ZapA; cl01146
342109002266	TIGR02449 family protein; Region: TIGR02449
342109002267	Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173
342109002268	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
342109002269	proline aminopeptidase P II; Provisional; Region: PRK10879
342109002270	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087
342109002271	active site
342109002272	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002273	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002274	proline dipeptidase; Provisional; Region: PRK13607
342109002275	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087
342109002276	active site
342109002277	PilZ domain; Region: PilZ; cl01260
342109002278	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
342109002279	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
342109002280	HemN family oxidoreductase; Provisional; Region: PRK05660
342109002281	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
342109002282	FeS/SAM binding site; other site
342109002283	HemN C-terminal region; Region: HemN_C; pfam06969
342109002284	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515
342109002285	active site
342109002286	dimerization interface [polypeptide binding]; other site
342109002287	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
342109002288	ribonuclease PH; Reviewed; Region: rph; PRK00173
342109002289	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
342109002290	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
342109002291	hypothetical protein; Provisional; Region: PRK11820
342109002292	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
342109002293	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
342109002294	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071
342109002295	catalytic site [active]
342109002296	G-X2-G-X-G-K; other site
342109002297	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002298	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109002299	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002300	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
342109002301	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
342109002302	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
342109002303	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
342109002304	synthetase active site [active]
342109002305	NTP binding site [chemical binding]; other site
342109002306	metal binding site [ion binding]; metal-binding site
342109002307	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
342109002308	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
342109002309	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
342109002310	homotrimer interaction site [polypeptide binding]; other site
342109002311	putative active site [active]
342109002312	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
342109002313	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488
342109002314	generic binding surface II; other site
342109002315	ssDNA binding site; other site
342109002316	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342109002317	ATP binding site [chemical binding]; other site
342109002318	putative Mg++ binding site [ion binding]; other site
342109002319	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109002320	nucleotide binding region [chemical binding]; other site
342109002321	ATP-binding site [chemical binding]; other site
342109002322	nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans.  Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base...; Region: nuc_hydro_CeIAG; cd02649
342109002323	active site
342109002324	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
342109002325	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
342109002326	dimer interface [polypeptide binding]; other site
342109002327	Citrate synthase; Region: Citrate_synt; pfam00285
342109002328	active site
342109002329	citrylCoA binding site [chemical binding]; other site
342109002330	NADH binding [chemical binding]; other site
342109002331	cationic pore residues; other site
342109002332	oxalacetate/citrate binding site [chemical binding]; other site
342109002333	coenzyme A binding site [chemical binding]; other site
342109002334	catalytic triad [active]
342109002335	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
342109002336	Transglycosylase; Region: Transgly; cl07896
342109002337	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
342109002338	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
342109002339	Competence protein A; Region: Competence_A; pfam11104
342109002340	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
342109002341	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
342109002342	Pilus assembly protein, PilO; Region: PilO; cl01234
342109002343	Pilus assembly protein, PilP; Region: PilP; cl01235
342109002344	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
342109002345	Secretin and TonB N terminus short domain; Region: STN; pfam07660
342109002346	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
342109002347	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
342109002348	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109002349	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002350	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002351	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109002352	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109002353	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109002354	Integrase core domain; Region: rve; cl01316
342109002355	MoxR-like ATPases [General function prediction only]; Region: COG0714
342109002356	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109002357	Walker A motif; other site
342109002358	ATP binding site [chemical binding]; other site
342109002359	Walker B motif; other site
342109002360	arginine finger; other site
342109002361	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109002362	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
342109002363	Protein of unknown function DUF58; Region: DUF58; pfam01882
342109002364	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_BatA_type; cd01467
342109002365	metal ion-dependent adhesion site (MIDAS); other site
342109002366	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
342109002367	metal ion-dependent adhesion site (MIDAS); other site
342109002368	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
342109002369	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
342109002370	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
342109002371	transketolase; Reviewed; Region: PRK12753
342109002372	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
342109002373	TPP-binding site [chemical binding]; other site
342109002374	dimer interface [polypeptide binding]; other site
342109002375	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
342109002376	PYR/PP interface [polypeptide binding]; other site
342109002377	dimer interface [polypeptide binding]; other site
342109002378	TPP binding site [chemical binding]; other site
342109002379	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
342109002380	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109002381	Peptidase family M23; Region: Peptidase_M23; pfam01551
342109002382	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
342109002383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
342109002384	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
342109002385	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109002386	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109002387	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109002388	Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589
342109002389	putative active site [active]
342109002390	catalytic site [active]
342109002391	putative metal binding site [ion binding]; other site
342109002392	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
342109002393	Thermostable hemolysin; Region: T_hemolysin; pfam12261
342109002394	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
342109002395	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
342109002396	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
342109002397	heme binding pocket [chemical binding]; other site
342109002398	heme ligand [chemical binding]; other site
342109002399	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
342109002400	classical (c) SDRs; Region: SDR_c; cd05233
342109002401	NAD(P) binding site [chemical binding]; other site
342109002402	active site
342109002403	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
342109002404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109002405	active site
342109002406	phosphorylation site [posttranslational modification]
342109002407	intermolecular recognition site; other site
342109002408	dimerization interface [polypeptide binding]; other site
342109002409	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109002410	DNA binding site [nucleotide binding]
342109002411	sensor protein QseC; Provisional; Region: PRK10337
342109002412	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
342109002413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109002414	ATP binding site [chemical binding]; other site
342109002415	Mg2+ binding site [ion binding]; other site
342109002416	G-X-G motif; other site
342109002417	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109002418	Peptidase family M48; Region: Peptidase_M48; cl12018
342109002419	Gram-negative bacterial tonB protein; Region: TonB; cl10048
342109002420	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109002421	Walker A/P-loop; other site
342109002422	ATP binding site [chemical binding]; other site
342109002423	Q-loop/lid; other site
342109002424	ABC transporter signature motif; other site
342109002425	Walker B; other site
342109002426	D-loop; other site
342109002427	H-loop/switch region; other site
342109002428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
342109002429	dimer interface [polypeptide binding]; other site
342109002430	conserved gate region; other site
342109002431	putative PBP binding loops; other site
342109002432	ABC-ATPase subunit interface; other site
342109002433	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109002434	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
342109002435	S1/P1 Nuclease; Region: S1-P1_nuclease; pfam02265
342109002436	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109002437	Surface antigen; Region: Surface_Ag_2; cl01155
342109002438	Surface antigen; Region: Surface_Ag_2; cl01155
342109002439	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109002440	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
342109002441	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
342109002442	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002443	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002444	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109002445	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109002446	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
342109002447	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109002448	dimer interface [polypeptide binding]; other site
342109002449	phosphorylation site [posttranslational modification]
342109002450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109002451	ATP binding site [chemical binding]; other site
342109002452	Mg2+ binding site [ion binding]; other site
342109002453	G-X-G motif; other site
342109002454	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
342109002455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109002456	active site
342109002457	phosphorylation site [posttranslational modification]
342109002458	intermolecular recognition site; other site
342109002459	dimerization interface [polypeptide binding]; other site
342109002460	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109002461	DNA binding site [nucleotide binding]
342109002462	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
342109002463	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109002464	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109002465	Transposase domain (DUF772); Region: DUF772; cl12084
342109002466	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109002467	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
342109002468	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
342109002469	active site
342109002470	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
342109002471	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002472	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109002473	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002474	Ion transport protein; Region: Ion_trans; pfam00520
342109002475	Ion channel; Region: Ion_trans_2; cl11596
342109002476	acetylornithine transaminase protein; Provisional; Region: argD; PRK04612
342109002477	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
342109002478	inhibitor-cofactor binding pocket; inhibition site
342109002479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109002480	catalytic residue [active]
342109002481	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
342109002482	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109002483	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
342109002484	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109002485	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109002486	Cytochrome c; Region: Cytochrom_C; cl11414
342109002487	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151
342109002488	homotrimer interaction site [polypeptide binding]; other site
342109002489	putative active site [active]
342109002490	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109002491	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109002492	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109002493	catalytic residue [active]
342109002494	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109002495	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
342109002496	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
342109002497	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
342109002498	DNA binding residues [nucleotide binding]
342109002499	dimerization interface [polypeptide binding]; other site
342109002500	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
342109002501	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
342109002502	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
342109002503	inhibitor-cofactor binding pocket; inhibition site
342109002504	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109002505	catalytic residue [active]
342109002506	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
342109002507	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109002508	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109002509	Integrase core domain; Region: rve; cl01316
342109002510	Integrase core domain; Region: rve; cl01316
342109002511	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109002512	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109002513	Phage protein; Region: DUF3653; pfam12375
342109002514	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109002515	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109002516	Phage protein; Region: DUF3653; pfam12375
342109002517	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109002518	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109002519	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109002520	Phage protein; Region: DUF3653; pfam12375
342109002521	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109002522	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109002523	Integrase core domain; Region: rve; cl01316
342109002524	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717
342109002525	substrate binding site [chemical binding]; other site
342109002526	active site
342109002527	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
342109002528	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
342109002529	active site
342109002530	dimer interface [polypeptide binding]; other site
342109002531	metal binding site [ion binding]; metal-binding site
342109002532	shikimate kinase; Reviewed; Region: aroK; PRK00131
342109002533	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464
342109002534	ADP binding site [chemical binding]; other site
342109002535	magnesium binding site [ion binding]; other site
342109002536	putative shikimate binding site; other site
342109002537	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
342109002538	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
342109002539	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
342109002540	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551
342109002541	PspA/IM30 family; Region: PspA_IM30; pfam04012
342109002542	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
342109002543	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
342109002544	Predicted membrane protein [Function unknown]; Region: COG3766
342109002545	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
342109002546	Protein of unknown function (DUF1190); Region: DUF1190; cl10031
342109002547	Glutathionylspermidine synthase; Region: GSP_synth; cl00503
342109002548	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
342109002549	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
342109002550	DNA binding residues [nucleotide binding]
342109002551	dimer interface [polypeptide binding]; other site
342109002552	[2Fe-2S] cluster binding site [ion binding]; other site
342109002553	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
342109002554	Zn binding site [ion binding]; other site
342109002555	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109002556	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109002557	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109002558	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109002559	SapC; Region: SapC; pfam07277
342109002560	Uncharacterized conserved protein [Function unknown]; Region: COG2850
342109002561	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109002562	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
342109002563	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
342109002564	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
342109002565	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
342109002566	Autoinducer binding domain; Region: Autoind_bind; pfam03472
342109002567	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
342109002568	DNA binding residues [nucleotide binding]
342109002569	dimerization interface [polypeptide binding]; other site
342109002570	proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
342109002571	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
342109002572	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109002573	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109002574	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
342109002575	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
342109002576	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
342109002577	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109002578	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
342109002579	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109002580	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
342109002581	MgtE intracellular N domain; Region: MgtE_N; cl15244
342109002582	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
342109002583	Divalent cation transporter; Region: MgtE; cl00786
342109002584	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
342109002585	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
342109002586	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
342109002587	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
342109002588	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
342109002589	dimerization domain swap beta strand [polypeptide binding]; other site
342109002590	regulatory protein interface [polypeptide binding]; other site
342109002591	active site
342109002592	regulatory phosphorylation site [posttranslational modification]; other site
342109002593	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006
342109002594	active pocket/dimerization site; other site
342109002595	active site
342109002596	phosphorylation site [posttranslational modification]
342109002597	P-loop ATPase protein family; Region: ATP_bind_2; cl10035
342109002598	HPr kinase/phosphorylase; Provisional; Region: PRK05428
342109002599	DRTGG domain; Region: DRTGG; cl12147
342109002600	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918
342109002601	Hpr binding site; other site
342109002602	active site
342109002603	homohexamer subunit interaction site [polypeptide binding]; other site
342109002604	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
342109002605	active site
342109002606	phosphorylation site [posttranslational modification]
342109002607	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552
342109002608	30S subunit binding site; other site
342109002609	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
342109002610	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
342109002611	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
342109002612	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
342109002613	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
342109002614	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
342109002615	Walker A/P-loop; other site
342109002616	ATP binding site [chemical binding]; other site
342109002617	Q-loop/lid; other site
342109002618	ABC transporter signature motif; other site
342109002619	Walker B; other site
342109002620	D-loop; other site
342109002621	H-loop/switch region; other site
342109002622	OstA-like protein; Region: OstA; cl00844
342109002623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
342109002624	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
342109002625	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
342109002626	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014
342109002627	putative active site [active]
342109002628	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
342109002629	BolA-like protein; Region: BolA; cl00386
342109002630	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369
342109002631	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
342109002632	hinge; other site
342109002633	active site
342109002634	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
342109002635	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
342109002636	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
342109002637	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
342109002638	active site
342109002639	substrate binding site [chemical binding]; other site
342109002640	cosubstrate binding site; other site
342109002641	catalytic site [active]
342109002642	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
342109002643	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
342109002644	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196
342109002645	dimerization interface [polypeptide binding]; other site
342109002646	putative ATP binding site [chemical binding]; other site
342109002647	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; cl01278
342109002648	Domain of unknown function DUF20; Region: UPF0118; cl00465
342109002649	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109002650	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
342109002651	Substrate binding site [chemical binding]; other site
342109002652	metal binding site [ion binding]; metal-binding site
342109002653	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
342109002654	Phosphotransferase enzyme family; Region: APH; pfam01636
342109002655	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
342109002656	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109002657	Integrase core domain; Region: rve; cl01316
342109002658	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
342109002659	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
342109002660	metal binding site [ion binding]; metal-binding site
342109002661	putative dimer interface [polypeptide binding]; other site
342109002662	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
342109002663	putative transposase OrfB; Reviewed; Region: PHA02517
342109002664	Integrase core domain; Region: rve; cl01316
342109002665	HutD; Region: HutD; cl01532
342109002666	HutD; Region: HutD; cl01532
342109002667	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109002668	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109002669	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
342109002670	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
342109002671	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
342109002672	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
342109002673	active site
342109002674	catalytic residues [active]
342109002675	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
342109002676	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109002677	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109002678	signal recognition particle protein; Provisional; Region: PRK10867
342109002679	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
342109002680	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
342109002681	P loop; other site
342109002682	GTP binding site [chemical binding]; other site
342109002683	Signal peptide binding domain; Region: SRP_SPB; pfam02978
342109002684	Nitronate monooxygenase; Region: NMO; pfam03060
342109002685	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730
342109002686	FMN binding site [chemical binding]; other site
342109002687	substrate binding site [chemical binding]; other site
342109002688	putative catalytic residue [active]
342109002689	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
342109002690	homodimer interface [polypeptide binding]; other site
342109002691	substrate-cofactor binding pocket; other site
342109002692	Aminotransferase class IV; Region: Aminotran_4; pfam01063
342109002693	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109002694	catalytic residue [active]
342109002695	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
342109002696	16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
342109002697	RimM N-terminal domain; Region: RimM; pfam01782
342109002698	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959
342109002699	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
342109002700	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
342109002701	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
342109002702	MatE; Region: MatE; pfam01554
342109002703	MatE; Region: MatE; pfam01554
342109002704	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
342109002705	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109002706	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109002707	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109002708	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
342109002709	GSH binding site (G-site) [chemical binding]; other site
342109002710	C-terminal domain interface [polypeptide binding]; other site
342109002711	dimer interface [polypeptide binding]; other site
342109002712	GIY-YIG catalytic domain; Region: GIY-YIG; cl01061
342109002713	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
342109002714	Clp amino terminal domain; Region: Clp_N; pfam02861
342109002715	Clp amino terminal domain; Region: Clp_N; pfam02861
342109002716	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109002717	Walker A motif; other site
342109002718	ATP binding site [chemical binding]; other site
342109002719	Walker B motif; other site
342109002720	arginine finger; other site
342109002721	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109002722	Walker A motif; other site
342109002723	ATP binding site [chemical binding]; other site
342109002724	Walker B motif; other site
342109002725	arginine finger; other site
342109002726	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
342109002727	Integrase core domain; Region: rve; cl01316
342109002728	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109002729	TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779
342109002730	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109002731	N-terminal plug; other site
342109002732	ligand-binding site [chemical binding]; other site
342109002733	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109002734	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
342109002735	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
342109002736	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561
342109002737	homodimer interface [polypeptide binding]; other site
342109002738	Walker A motif; other site
342109002739	ATP binding site [chemical binding]; other site
342109002740	hydroxycobalamin binding site [chemical binding]; other site
342109002741	Walker B motif; other site
342109002742	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544
342109002743	homotrimer interface [polypeptide binding]; other site
342109002744	Walker A motif; other site
342109002745	GTP binding site [chemical binding]; other site
342109002746	Walker B motif; other site
342109002747	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
342109002748	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
342109002749	putative dimer interface [polypeptide binding]; other site
342109002750	active site pocket [active]
342109002751	putative cataytic base [active]
342109002752	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
342109002753	catalytic core [active]
342109002754	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
342109002755	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
342109002756	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
342109002757	dimer interface [polypeptide binding]; other site
342109002758	active site
342109002759	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
342109002760	catalytic residues [active]
342109002761	substrate binding site [chemical binding]; other site
342109002762	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
342109002763	IucA / IucC family; Region: IucA_IucC; pfam04183
342109002764	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
342109002765	drug efflux system protein MdtG; Provisional; Region: PRK09874
342109002766	IucA / IucC family; Region: IucA_IucC; pfam04183
342109002767	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
342109002768	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109002769	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
342109002770	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109002771	N-terminal plug; other site
342109002772	ligand-binding site [chemical binding]; other site
342109002773	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
342109002774	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
342109002775	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109002776	putative transposase OrfB; Reviewed; Region: PHA02517
342109002777	Integrase core domain; Region: rve; cl01316
342109002778	putative cation:proton antiport protein; Provisional; Region: PRK10669
342109002779	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
342109002780	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109002781	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
342109002782	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109002783	N-terminal plug; other site
342109002784	ligand-binding site [chemical binding]; other site
342109002785	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
342109002786	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109002787	N-terminal plug; other site
342109002788	ligand-binding site [chemical binding]; other site
342109002789	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
342109002790	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
342109002791	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109002792	N-terminal plug; other site
342109002793	ligand-binding site [chemical binding]; other site
342109002794	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
342109002795	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
342109002796	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109002797	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
342109002798	ABC transporter; Region: ABC_tran_2; pfam12848
342109002799	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
342109002800	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
342109002801	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109002802	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109002803	dimerization interface [polypeptide binding]; other site
342109002804	Beta-lactamase; Region: Beta-lactamase; cl01009
342109002805	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109002806	Transposase domain (DUF772); Region: DUF772; cl12084
342109002807	Protein of unknown function (DUF805); Region: DUF805; cl01224
342109002808	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
342109002809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
342109002810	active site
342109002811	phosphorylation site [posttranslational modification]
342109002812	intermolecular recognition site; other site
342109002813	dimerization interface [polypeptide binding]; other site
342109002814	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109002815	DNA binding site [nucleotide binding]
342109002816	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
342109002817	Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326
342109002818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
342109002819	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
342109002820	Integrase core domain; Region: rve; cl01316
342109002821	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109002822	Transposase, Mutator family; Region: Transposase_mut; pfam00872
342109002823	MULE transposase domain; Region: MULE; pfam10551
342109002824	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
342109002825	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
342109002826	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
342109002827	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
342109002828	proposed active site lysine [active]
342109002829	conserved cys residue [active]
342109002830	LysE type translocator; Region: LysE; cl00565
342109002831	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
342109002832	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
342109002833	catalytic triad [active]
342109002834	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
342109002835	Fatty acid desaturase; Region: FA_desaturase; pfam00487
342109002836	putative di-iron ligands [ion binding]; other site
342109002837	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
342109002838	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
342109002839	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109002840	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109002841	catalytic residue [active]
342109002842	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109002843	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109002844	catalytic residue [active]
342109002845	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109002846	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109002847	Integrase core domain; Region: rve; cl01316
342109002848	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109002849	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528
342109002850	[2Fe-2S] cluster binding site [ion binding]; other site
342109002851	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342109002852	Coenzyme A binding pocket [chemical binding]; other site
342109002853	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109002854	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
342109002855	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
342109002856	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109002857	catalytic residue [active]
342109002858	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
342109002859	FeS assembly ATPase SufC; Region: sufC; TIGR01978
342109002860	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
342109002861	Walker A/P-loop; other site
342109002862	ATP binding site [chemical binding]; other site
342109002863	Q-loop/lid; other site
342109002864	ABC transporter signature motif; other site
342109002865	Walker B; other site
342109002866	D-loop; other site
342109002867	H-loop/switch region; other site
342109002868	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
342109002869	putative ABC transporter; Region: ycf24; CHL00085
342109002870	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
342109002871	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109002872	SET domain; Region: SET; cl02566
342109002873	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
342109002874	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
342109002875	conserved cys residue [active]
342109002876	Peptidase family M23; Region: Peptidase_M23; pfam01551
342109002877	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cl00257
342109002878	Transposase domain (DUF772); Region: DUF772; cl12084
342109002879	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109002880	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109002881	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109002882	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
342109002883	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
342109002884	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
342109002885	catalytic residue [active]
342109002886	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
342109002887	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
342109002888	Walker A motif; other site
342109002889	ATP binding site [chemical binding]; other site
342109002890	Walker B motif; other site
342109002891	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
342109002892	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
342109002893	Walker A motif; other site
342109002894	ATP binding site [chemical binding]; other site
342109002895	Walker B motif; other site
342109002896	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
342109002897	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
342109002898	Protein of unknown function DUF72; Region: DUF72; cl00777
342109002899	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
342109002900	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
342109002901	Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525
342109002902	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
342109002903	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
342109002904	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
342109002905	OsmC-like protein; Region: OsmC; cl00767
342109002906	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
342109002907	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
342109002908	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
342109002909	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
342109002910	bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961
342109002911	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
342109002912	nucleotide binding site [chemical binding]; other site
342109002913	substrate binding site [chemical binding]; other site
342109002914	ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935
342109002915	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
342109002916	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
342109002917	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
342109002918	catalytic residue [active]
342109002919	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690
342109002920	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
342109002921	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
342109002922	octaprenyl diphosphate synthase; Provisional; Region: PRK10888
342109002923	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
342109002924	substrate binding pocket [chemical binding]; other site
342109002925	chain length determination region; other site
342109002926	substrate-Mg2+ binding site; other site
342109002927	catalytic residues [active]
342109002928	aspartate-rich region 1; other site
342109002929	active site lid residues [active]
342109002930	aspartate-rich region 2; other site
342109002931	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
342109002932	dimer interface [polypeptide binding]; other site
342109002933	ssDNA binding site [nucleotide binding]; other site
342109002934	tetramer (dimer of dimers) interface [polypeptide binding]; other site
342109002935	Cache domain; Region: Cache_1; pfam02743
342109002936	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109002937	metal binding site [ion binding]; metal-binding site
342109002938	active site
342109002939	I-site; other site
342109002940	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
342109002941	putative NAD(P) binding site [chemical binding]; other site
342109002942	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
342109002943	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109002944	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002945	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002946	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109002947	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109002948	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
342109002949	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
342109002950	motif II; other site
342109002951	Protein of unknown function (DUF466); Region: DUF466; cl01082
342109002952	Carbon starvation protein CstA; Region: CstA; cl00856
342109002953	Pirin-related protein [General function prediction only]; Region: COG1741
342109002954	Cupin domain; Region: Cupin_2; cl09118
342109002955	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
342109002956	OsmC-like protein; Region: OsmC; cl00767
342109002957	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109002958	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109002959	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109002960	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109002961	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
342109002962	Transposase domain (DUF772); Region: DUF772; cl12084
342109002963	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109002964	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109002965	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109002966	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109002967	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109002968	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109002969	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002970	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109002971	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109002972	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
342109002973	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109002974	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109002975	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109002976	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109002977	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109002978	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109002979	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109002980	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
342109002981	Pirin-related protein [General function prediction only]; Region: COG1741
342109002982	Cupin domain; Region: Cupin_2; cl09118
342109002983	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
342109002984	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
342109002985	Active_site [active]
342109002986	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
342109002987	catalytic core [active]
342109002988	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
342109002989	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
342109002990	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
342109002991	active site
342109002992	Zn binding site [ion binding]; other site
342109002993	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
342109002994	putative active site [active]
342109002995	catalytic site [active]
342109002996	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
342109002997	putative active site [active]
342109002998	catalytic site [active]
342109002999	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
342109003000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109003001	active site
342109003002	phosphorylation site [posttranslational modification]
342109003003	intermolecular recognition site; other site
342109003004	dimerization interface [polypeptide binding]; other site
342109003005	CheB methylesterase; Region: CheB_methylest; pfam01339
342109003006	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
342109003007	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
342109003008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109003009	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109003010	active site
342109003011	phosphorylation site [posttranslational modification]
342109003012	intermolecular recognition site; other site
342109003013	dimerization interface [polypeptide binding]; other site
342109003014	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
342109003015	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
342109003016	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
342109003017	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
342109003018	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
342109003019	putative binding surface; other site
342109003020	active site
342109003021	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
342109003022	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109003023	ATP binding site [chemical binding]; other site
342109003024	Mg2+ binding site [ion binding]; other site
342109003025	G-X-G motif; other site
342109003026	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
342109003027	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
342109003028	anti sigma factor interaction site; other site
342109003029	regulatory phosphorylation site [posttranslational modification]; other site
342109003030	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
342109003031	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
342109003032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342109003033	ATP binding site [chemical binding]; other site
342109003034	putative Mg++ binding site [ion binding]; other site
342109003035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109003036	nucleotide binding region [chemical binding]; other site
342109003037	ATP-binding site [chemical binding]; other site
342109003038	TRCF domain; Region: TRCF; pfam03461
342109003039	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
342109003040	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109003041	Protein of unknown function (DUF519); Region: DUF519; cl04492
342109003042	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109003043	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109003044	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109003045	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109003046	dimer interface [polypeptide binding]; other site
342109003047	phosphorylation site [posttranslational modification]
342109003048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109003049	ATP binding site [chemical binding]; other site
342109003050	Mg2+ binding site [ion binding]; other site
342109003051	G-X-G motif; other site
342109003052	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109003053	Integrase core domain; Region: rve; cl01316
342109003054	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
342109003055	active site
342109003056	Inner membrane protein CreD; Region: CreD; cl01844
342109003057	Transposase domain (DUF772); Region: DUF772; cl12084
342109003058	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109003059	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109003060	Integrase core domain; Region: rve; cl01316
342109003061	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
342109003062	active site
342109003063	Inner membrane protein CreD; Region: CreD; cl01844
342109003064	Transposase domain (DUF772); Region: DUF772; cl12084
342109003065	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109003066	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
342109003067	active site
342109003068	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109003069	Integrase core domain; Region: rve; cl01316
342109003070	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
342109003071	putative active site [active]
342109003072	catalytic triad [active]
342109003073	putative dimer interface [polypeptide binding]; other site
342109003074	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
342109003075	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
342109003076	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
342109003077	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
342109003078	active site
342109003079	HIGH motif; other site
342109003080	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
342109003081	active site
342109003082	KMSKS motif; other site
342109003083	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
342109003084	metal binding site 2 [ion binding]; metal-binding site
342109003085	putative DNA binding helix; other site
342109003086	metal binding site 1 [ion binding]; metal-binding site
342109003087	dimer interface [polypeptide binding]; other site
342109003088	structural Zn2+ binding site [ion binding]; other site
342109003089	Cupin domain; Region: Cupin_2; cl09118
342109003090	Protein of unknown function (DUF456); Region: DUF456; cl01069
342109003091	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
342109003092	DNA-binding site [nucleotide binding]; DNA binding site
342109003093	RNA-binding motif; other site
342109003094	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
342109003095	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755
342109003096	putative ATP binding site [chemical binding]; other site
342109003097	putative substrate interface [chemical binding]; other site
342109003098	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
342109003099	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
342109003100	active site
342109003101	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
342109003102	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
342109003103	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
342109003104	active site
342109003105	Domain of Unknown Function with PDB structure; Region: DUF3857; pfam12969
342109003106	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
342109003107	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
342109003108	putative C-terminal domain interface [polypeptide binding]; other site
342109003109	putative GSH binding site (G-site) [chemical binding]; other site
342109003110	putative dimer interface [polypeptide binding]; other site
342109003111	GST_C family, unknown subfamily 1; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_1; cd03179
342109003112	putative N-terminal domain interface [polypeptide binding]; other site
342109003113	putative dimer interface [polypeptide binding]; other site
342109003114	putative substrate binding pocket (H-site) [chemical binding]; other site
342109003115	exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
342109003116	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
342109003117	active site
342109003118	dimer interface [polypeptide binding]; other site
342109003119	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes...; Region: Asn_Synthase_B_C; cd01991
342109003120	Ligand Binding Site [chemical binding]; other site
342109003121	Molecular Tunnel; other site
342109003122	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
342109003123	replicative DNA helicase; Provisional; Region: PRK08760
342109003124	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
342109003125	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
342109003126	Walker A motif; other site
342109003127	ATP binding site [chemical binding]; other site
342109003128	Walker B motif; other site
342109003129	DNA binding loops [nucleotide binding]
342109003130	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
342109003131	DNA photolyase; Region: DNA_photolyase; pfam00875
342109003132	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
342109003133	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
342109003134	ligand binding site [chemical binding]; other site
342109003135	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109003136	active site
342109003137	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109003138	Integrase core domain; Region: rve; cl01316
342109003139	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
342109003140	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109003141	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109003142	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
342109003143	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109003144	N-terminal plug; other site
342109003145	ligand-binding site [chemical binding]; other site
342109003146	MerC mercury resistance protein; Region: MerC; cl03934
342109003147	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
342109003148	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260
342109003149	putative NAD(P) binding site [chemical binding]; other site
342109003150	catalytic Zn binding site [ion binding]; other site
342109003151	structural Zn binding site [ion binding]; other site
342109003152	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
342109003153	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
342109003154	putative ion selectivity filter; other site
342109003155	putative pore gating glutamate residue; other site
342109003156	putative H+/Cl- coupling transport residue; other site
342109003157	Sulfatase; Region: Sulfatase; cl10460
342109003158	Sulfatase; Region: Sulfatase; cl10460
342109003159	Transposase domain (DUF772); Region: DUF772; cl12084
342109003160	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109003161	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
342109003162	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
342109003163	DNA binding site [nucleotide binding]
342109003164	active site
342109003165	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
342109003166	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
342109003167	AlkA N-terminal domain; Region: AlkA_N; pfam06029
342109003168	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
342109003169	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
342109003170	minor groove reading motif; other site
342109003171	helix-hairpin-helix signature motif; other site
342109003172	substrate binding pocket [chemical binding]; other site
342109003173	active site
342109003174	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780
342109003175	MAPEG family; Region: MAPEG; cl09190
342109003176	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
342109003177	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
342109003178	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
342109003179	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
342109003180	ATP binding site [chemical binding]; other site
342109003181	Mg++ binding site [ion binding]; other site
342109003182	motif III; other site
342109003183	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109003184	nucleotide binding region [chemical binding]; other site
342109003185	ATP-binding site [chemical binding]; other site
342109003186	DbpA RNA binding domain; Region: DbpA; pfam03880
342109003187	PAS domain S-box; Region: sensory_box; TIGR00229
342109003188	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342109003189	putative active site [active]
342109003190	heme pocket [chemical binding]; other site
342109003191	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109003192	metal binding site [ion binding]; metal-binding site
342109003193	active site
342109003194	I-site; other site
342109003195	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
342109003196	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
342109003197	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
342109003198	PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554
342109003199	probable active site [active]
342109003200	EamA-like transporter family; Region: EamA; cl01037
342109003201	Protein of unknown function DUF72; Region: DUF72; cl00777
342109003202	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
342109003203	Beta-lactamase; Region: Beta-lactamase; cl01009
342109003204	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
342109003205	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
342109003206	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
342109003207	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
342109003208	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
342109003209	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109003210	dimer interface [polypeptide binding]; other site
342109003211	phosphorylation site [posttranslational modification]
342109003212	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109003213	ATP binding site [chemical binding]; other site
342109003214	Mg2+ binding site [ion binding]; other site
342109003215	G-X-G motif; other site
342109003216	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
342109003217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109003218	active site
342109003219	phosphorylation site [posttranslational modification]
342109003220	intermolecular recognition site; other site
342109003221	dimerization interface [polypeptide binding]; other site
342109003222	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109003223	DNA binding site [nucleotide binding]
342109003224	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
342109003225	Outer membrane efflux protein; Region: OEP; pfam02321
342109003226	Outer membrane efflux protein; Region: OEP; pfam02321
342109003227	MltA-interacting protein MipA; Region: MipA; cl01504
342109003228	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
342109003229	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
342109003230	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
342109003231	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
342109003232	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
342109003233	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
342109003234	Walker A/P-loop; other site
342109003235	ATP binding site [chemical binding]; other site
342109003236	Q-loop/lid; other site
342109003237	ABC transporter signature motif; other site
342109003238	Walker B; other site
342109003239	D-loop; other site
342109003240	H-loop/switch region; other site
342109003241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109003242	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109003243	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109003244	Transposase domain (DUF772); Region: DUF772; cl12084
342109003245	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109003246	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
342109003247	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
342109003248	RHS Repeat; Region: RHS_repeat; cl11982
342109003249	RHS Repeat; Region: RHS_repeat; cl11982
342109003250	RHS Repeat; Region: RHS_repeat; cl11982
342109003251	RHS Repeat; Region: RHS_repeat; cl11982
342109003252	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
342109003253	Transposase domain (DUF772); Region: DUF772; cl12084
342109003254	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109003255	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
342109003256	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
342109003257	Transposase domain (DUF772); Region: DUF772; cl12084
342109003258	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109003259	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109003260	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109003261	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
342109003262	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
342109003263	CoA-binding site [chemical binding]; other site
342109003264	ATP-binding [chemical binding]; other site
342109003265	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
342109003266	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
342109003267	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
342109003268	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
342109003269	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
342109003270	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
342109003271	Pilin (bacterial filament); Region: Pilin; pfam00114
342109003272	Sulfatase; Region: Sulfatase; cl10460
342109003273	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
342109003274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109003275	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
342109003276	GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
342109003277	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
342109003278	Walker A motif; other site
342109003279	ATP binding site [chemical binding]; other site
342109003280	Walker B motif; other site
342109003281	Fic/DOC family; Region: Fic; cl00960
342109003282	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
342109003283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109003284	active site
342109003285	phosphorylation site [posttranslational modification]
342109003286	intermolecular recognition site; other site
342109003287	dimerization interface [polypeptide binding]; other site
342109003288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109003289	Walker A motif; other site
342109003290	ATP binding site [chemical binding]; other site
342109003291	Walker B motif; other site
342109003292	arginine finger; other site
342109003293	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
342109003294	Predicted integral membrane protein [Function unknown]; Region: COG5617
342109003295	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
342109003296	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109003297	dimer interface [polypeptide binding]; other site
342109003298	phosphorylation site [posttranslational modification]
342109003299	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109003300	ATP binding site [chemical binding]; other site
342109003301	Mg2+ binding site [ion binding]; other site
342109003302	G-X-G motif; other site
342109003303	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
342109003304	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109003305	CoA-ligase; Region: Ligase_CoA; pfam00549
342109003306	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
342109003307	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109003308	CoA-ligase; Region: Ligase_CoA; pfam00549
342109003309	NAD synthetase; Provisional; Region: PRK13981
342109003310	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
342109003311	multimer interface [polypeptide binding]; other site
342109003312	active site
342109003313	catalytic triad [active]
342109003314	protein interface 1 [polypeptide binding]; other site
342109003315	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
342109003316	homodimer interface [polypeptide binding]; other site
342109003317	NAD binding pocket [chemical binding]; other site
342109003318	ATP binding pocket [chemical binding]; other site
342109003319	Mg binding site [ion binding]; other site
342109003320	active-site loop [active]
342109003321	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
342109003322	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
342109003323	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
342109003324	RNA binding surface [nucleotide binding]; other site
342109003325	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
342109003326	active site
342109003327	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
342109003328	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
342109003329	Protein of unknown function, DUF393; Region: DUF393; cl01136
342109003330	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788
342109003331	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
342109003332	active site
342109003333	homotetramer interface [polypeptide binding]; other site
342109003334	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
342109003335	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
342109003336	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
342109003337	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
342109003338	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
342109003339	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109003340	N-terminal plug; other site
342109003341	ligand-binding site [chemical binding]; other site
342109003342	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
342109003343	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
342109003344	active site
342109003345	catalytic residues [active]
342109003346	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
342109003347	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
342109003348	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
342109003349	Secreted protein acidic and rich in cysteine Ca binding region; Region: SPARC_Ca_bdg; pfam10591
342109003350	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051
342109003351	Ca2+ binding site [ion binding]; other site
342109003352	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109003353	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109003354	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109003355	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
342109003356	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342109003357	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
342109003358	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
342109003359	active site
342109003360	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
342109003361	catalytic triad [active]
342109003362	dimer interface [polypeptide binding]; other site
342109003363	enoyl-CoA hydratase; Provisional; Region: PRK07854
342109003364	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
342109003365	substrate binding site [chemical binding]; other site
342109003366	oxyanion hole (OAH) forming residues; other site
342109003367	trimer interface [polypeptide binding]; other site
342109003368	Protein of unknown function (DUF461); Region: DUF461; cl01071
342109003369	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
342109003370	active site
342109003371	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
342109003372	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
342109003373	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
342109003374	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
342109003375	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
342109003376	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
342109003377	GTPase CgtA; Reviewed; Region: obgE; PRK12299
342109003378	GTP1/OBG; Region: GTP1_OBG; pfam01018
342109003379	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
342109003380	G1 box; other site
342109003381	GTP/Mg2+ binding site [chemical binding]; other site
342109003382	Switch I region; other site
342109003383	G2 box; other site
342109003384	G3 box; other site
342109003385	Switch II region; other site
342109003386	G4 box; other site
342109003387	G5 box; other site
342109003388	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
342109003389	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
342109003390	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
342109003391	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
342109003392	active site
342109003393	Riboflavin kinase; Region: Flavokinase; pfam01687
342109003394	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
342109003395	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
342109003396	active site
342109003397	HIGH motif; other site
342109003398	nucleotide binding site [chemical binding]; other site
342109003399	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
342109003400	active site
342109003401	KMSKS motif; other site
342109003402	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
342109003403	tRNA binding surface [nucleotide binding]; other site
342109003404	anticodon binding site; other site
342109003405	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
342109003406	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
342109003407	LytB protein; Region: LYTB; cl00507
342109003408	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
342109003409	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
342109003410	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
342109003411	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
342109003412	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
342109003413	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
342109003414	D-pathway; other site
342109003415	Putative ubiquinol binding site [chemical binding]; other site
342109003416	Low-spin heme (heme b) binding site [chemical binding]; other site
342109003417	Putative water exit pathway; other site
342109003418	Binuclear center (heme o3/CuB) [ion binding]; other site
342109003419	K-pathway; other site
342109003420	Putative proton exit pathway; other site
342109003421	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
342109003422	Subunit I/III interface [polypeptide binding]; other site
342109003423	Subunit III/IV interface [polypeptide binding]; other site
342109003424	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
342109003425	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
342109003426	Tetratricopeptide repeat; Region: TPR_3; pfam07720
342109003427	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
342109003428	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117
342109003429	protein binding site [polypeptide binding]; other site
342109003430	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109003431	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109003432	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
342109003433	RHS Repeat; Region: RHS_repeat; cl11982
342109003434	RHS Repeat; Region: RHS_repeat; cl11982
342109003435	RHS Repeat; Region: RHS_repeat; cl11982
342109003436	RHS Repeat; Region: RHS_repeat; cl11982
342109003437	RHS Repeat; Region: RHS_repeat; cl11982
342109003438	RHS Repeat; Region: RHS_repeat; cl11982
342109003439	RHS Repeat; Region: RHS_repeat; cl11982
342109003440	RHS Repeat; Region: RHS_repeat; cl11982
342109003441	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
342109003442	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
342109003443	RHS Repeat; Region: RHS_repeat; cl11982
342109003444	RHS Repeat; Region: RHS_repeat; cl11982
342109003445	RHS Repeat; Region: RHS_repeat; cl11982
342109003446	RHS Repeat; Region: RHS_repeat; cl11982
342109003447	RHS Repeat; Region: RHS_repeat; cl11982
342109003448	RHS Repeat; Region: RHS_repeat; cl11982
342109003449	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109003450	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
342109003451	Integrase core domain; Region: rve; cl01316
342109003452	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
342109003453	MutS domain I; Region: MutS_I; pfam01624
342109003454	MutS domain II; Region: MutS_II; pfam05188
342109003455	MutS family domain IV; Region: MutS_IV; pfam05190
342109003456	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
342109003457	Walker A/P-loop; other site
342109003458	ATP binding site [chemical binding]; other site
342109003459	Q-loop/lid; other site
342109003460	ABC transporter signature motif; other site
342109003461	Walker B; other site
342109003462	D-loop; other site
342109003463	H-loop/switch region; other site
342109003464	putative transposase OrfB; Reviewed; Region: PHA02517
342109003465	Integrase core domain; Region: rve; cl01316
342109003466	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109003467	DNA repair protein RadA; Provisional; Region: PRK11823
342109003468	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109003469	Walker A motif; other site
342109003470	ATP binding site [chemical binding]; other site
342109003471	Walker B motif; other site
342109003472	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
342109003473	Integrase core domain; Region: rve; cl01316
342109003474	putative transposase OrfB; Reviewed; Region: PHA02517
342109003475	Integrase core domain; Region: rve; cl01316
342109003476	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109003477	Phosphoesterase family; Region: Phosphoesterase; cl10627
342109003478	Domain of unknown function (DUF756); Region: DUF756; pfam05506
342109003479	Domain of unknown function (DUF756); Region: DUF756; pfam05506
342109003480	Phosphoesterase family; Region: Phosphoesterase; cl10627
342109003481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109003482	putative substrate translocation pore; other site
342109003483	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
342109003484	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
342109003485	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
342109003486	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
342109003487	dimer interface [polypeptide binding]; other site
342109003488	anticodon binding site; other site
342109003489	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
342109003490	homodimer interface [polypeptide binding]; other site
342109003491	motif 1; other site
342109003492	active site
342109003493	motif 2; other site
342109003494	GAD domain; Region: GAD; pfam02938
342109003495	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
342109003496	motif 3; other site
342109003497	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109003498	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
342109003499	Domain of unknown function DUF28; Region: DUF28; cl00361
342109003500	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
342109003501	active site
342109003502	putative DNA-binding cleft [nucleotide binding]; other site
342109003503	dimer interface [polypeptide binding]; other site
342109003504	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
342109003505	RuvA N terminal domain; Region: RuvA_N; pfam01330
342109003506	K+ potassium transporter; Region: K_trans; cl01227
342109003507	potassium uptake protein; Region: kup; TIGR00794
342109003508	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
342109003509	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109003510	Walker A motif; other site
342109003511	ATP binding site [chemical binding]; other site
342109003512	Walker B motif; other site
342109003513	arginine finger; other site
342109003514	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
342109003515	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
342109003516	active site
342109003517	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
342109003518	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
342109003519	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
342109003520	TolA protein; Region: tolA_full; TIGR02794
342109003521	translocation protein TolB; Provisional; Region: tolB; PRK04922
342109003522	TolB amino-terminal domain; Region: TolB_N; pfam04052
342109003523	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
342109003524	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
342109003525	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
342109003526	ligand binding site [chemical binding]; other site
342109003527	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
342109003528	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
342109003529	binding surface
342109003530	TPR motif; other site
342109003531	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
342109003532	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
342109003533	FeS/SAM binding site; other site
342109003534	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
342109003535	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
342109003536	RNA binding surface [nucleotide binding]; other site
342109003537	PSSA_1: Pseudouridine synthase, a subgroup of the RsuA family. This group is comprised of bacterial proteins assigned to the RsuA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSSA_1; cd02555
342109003538	active site
342109003539	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
342109003540	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
342109003541	LysE type translocator; Region: LysE; cl00565
342109003542	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109003543	Integrase core domain; Region: rve; cl01316
342109003544	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109003545	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109003546	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109003547	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109003548	Transposase domain (DUF772); Region: DUF772; cl12084
342109003549	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
342109003550	Ligand Binding Site [chemical binding]; other site
342109003551	C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182
342109003552	DNA binding site [nucleotide binding]
342109003553	Int/Topo IB signature motif; other site
342109003554	active site
342109003555	catalytic residues [active]
342109003556	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication...; Region: TOPRIM_primases; cd01029
342109003557	active site
342109003558	metal binding site [ion binding]; metal-binding site
342109003559	interdomain interaction site; other site
342109003560	Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl04623
342109003561	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
342109003562	Phage protein D [General function prediction only]; Region: COG3500; cl12180
342109003563	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
342109003564	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
342109003565	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
342109003566	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
342109003567	Phage-related protein [Function unknown]; Region: COG5412
342109003568	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
342109003569	Phage tail protein E; Region: Phage_E; pfam06158
342109003570	Phage tail tube protein FII; Region: Phage_tube; cl01390
342109003571	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
342109003572	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
342109003573	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109003574	Phage Tail Collar Domain; Region: Collar; pfam07484
342109003575	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
342109003576	Baseplate J-like protein; Region: Baseplate_J; cl01294
342109003577	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
342109003578	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
342109003579	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
342109003580	Protein of unknown function (DUF754); Region: DUF754; pfam05449
342109003581	Phage Tail Protein X; Region: Phage_tail_X; cl02088
342109003582	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
342109003583	Phage small terminase subunit; Region: Phage_term_smal; cl05485
342109003584	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
342109003585	capsid-scaffolding protein; Provisional; Region: O; PHA02529
342109003586	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929
342109003587	terminase ATPase subunit; Provisional; Region: P; PHA02535
342109003588	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
342109003589	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
342109003590	Phage-related protein [Function unknown]; Region: COG4695; cl01923
342109003591	phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540
342109003592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109003593	Uncharacterized conserved protein [Function unknown]; Region: COG4104
342109003594	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
342109003595	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
342109003596	active site
342109003597	DNA binding site [nucleotide binding]
342109003598	Response regulator receiver domain; Region: Response_reg; pfam00072
342109003599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109003600	active site
342109003601	phosphorylation site [posttranslational modification]
342109003602	intermolecular recognition site; other site
342109003603	dimerization interface [polypeptide binding]; other site
342109003604	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
342109003605	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342109003606	ATP binding site [chemical binding]; other site
342109003607	putative Mg++ binding site [ion binding]; other site
342109003608	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109003609	nucleotide binding region [chemical binding]; other site
342109003610	ATP-binding site [chemical binding]; other site
342109003611	RQC domain; Region: RQC; pfam09382
342109003612	HRDC domain; Region: HRDC; cl02578
342109003613	Ferritin-like domain; Region: Ferritin; pfam00210
342109003614	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
342109003615	dimerization interface [polypeptide binding]; other site
342109003616	DPS ferroxidase diiron center [ion binding]; other site
342109003617	ion pore; other site
342109003618	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342109003619	ATP binding site [chemical binding]; other site
342109003620	putative Mg++ binding site [ion binding]; other site
342109003621	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109003622	nucleotide binding region [chemical binding]; other site
342109003623	ATP-binding site [chemical binding]; other site
342109003624	Helicase associated domain (HA2); Region: HA2; cl04503
342109003625	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
342109003626	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
342109003627	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109003628	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109003629	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109003630	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
342109003631	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
342109003632	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
342109003633	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
342109003634	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109003635	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109003636	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
342109003637	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
342109003638	FeS/SAM binding site; other site
342109003639	radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085
342109003640	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
342109003641	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
342109003642	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
342109003643	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
342109003644	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
342109003645	synthetase active site [active]
342109003646	NTP binding site [chemical binding]; other site
342109003647	metal binding site [ion binding]; metal-binding site
342109003648	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
342109003649	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
342109003650	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
342109003651	Probable Catalytic site [active]
342109003652	metal binding site [ion binding]; metal-binding site
342109003653	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
342109003654	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
342109003655	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
342109003656	Transglycosylase; Region: Transgly; cl07896
342109003657	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
342109003658	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
342109003659	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
342109003660	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250
342109003661	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
342109003662	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
342109003663	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
342109003664	Gram-negative bacterial tonB protein; Region: TonB; cl10048
342109003665	glutathione synthetase; Provisional; Region: PRK05246
342109003666	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
342109003667	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109003668	Response regulator receiver domain; Region: Response_reg; pfam00072
342109003669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109003670	active site
342109003671	phosphorylation site [posttranslational modification]
342109003672	intermolecular recognition site; other site
342109003673	dimerization interface [polypeptide binding]; other site
342109003674	Response regulator receiver domain; Region: Response_reg; pfam00072
342109003675	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109003676	active site
342109003677	phosphorylation site [posttranslational modification]
342109003678	intermolecular recognition site; other site
342109003679	dimerization interface [polypeptide binding]; other site
342109003680	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
342109003681	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
342109003682	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
342109003683	ribonuclease E; Reviewed; Region: rne; PRK10811
342109003684	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
342109003685	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
342109003686	putative binding surface; other site
342109003687	active site
342109003688	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
342109003689	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109003690	ATP binding site [chemical binding]; other site
342109003691	Mg2+ binding site [ion binding]; other site
342109003692	G-X-G motif; other site
342109003693	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
342109003694	Response regulator receiver domain; Region: Response_reg; pfam00072
342109003695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109003696	active site
342109003697	phosphorylation site [posttranslational modification]
342109003698	intermolecular recognition site; other site
342109003699	dimerization interface [polypeptide binding]; other site
342109003700	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
342109003701	CheB methylesterase; Region: CheB_methylest; pfam01339
342109003702	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
342109003703	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109003704	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109003705	Integrase core domain; Region: rve; cl01316
342109003706	von Willebrand factor; Region: vWF_A; pfam12450
342109003707	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_subgroup; cd01465
342109003708	metal ion-dependent adhesion site (MIDAS); other site
342109003709	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109003710	multicopper oxidase; Provisional; Region: PRK10965
342109003711	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (...; Region: Glycosylasparaginase; cd04513
342109003712	active site
342109003713	dimer interface [polypeptide binding]; other site
342109003714	catalytic nucleophile [active]
342109003715	CutC family; Region: CutC; cl01218
342109003716	Resistant to P. syringae 6; Provisional; Region: PLN03210
342109003717	Resistant to P. syringae 6; Provisional; Region: PLN03210
342109003718	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
342109003719	Asp-box motif; other site
342109003720	Killing trait; Region: RebB; pfam11747
342109003721	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109003722	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109003723	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
342109003724	Beta-galactosidase; Region: Glyco_hydro_42; cl03154
342109003725	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
342109003726	alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180
342109003727	Uncharacterized conserved protein [Function unknown]; Region: COG3538
342109003728	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
342109003729	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404
342109003730	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
342109003731	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404
342109003732	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109003733	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109003734	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
342109003735	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
342109003736	putative active site [active]
342109003737	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
342109003738	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109003739	Walker A/P-loop; other site
342109003740	ATP binding site [chemical binding]; other site
342109003741	Q-loop/lid; other site
342109003742	ABC transporter signature motif; other site
342109003743	Walker B; other site
342109003744	D-loop; other site
342109003745	H-loop/switch region; other site
342109003746	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
342109003747	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
342109003748	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
342109003749	PA14 domain; Region: PA14; cl08459
342109003750	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
342109003751	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
342109003752	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
342109003753	domain; Region: Glyco_hydro_2; pfam00703
342109003754	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895
342109003755	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i); Region: GH20_chitobiase-like; cd06563
342109003756	active site
342109003757	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
342109003758	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
342109003759	active site
342109003760	Glycosyl hydrolase family 18; Region: Glyco_18; smart00636
342109003761	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
342109003762	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109003763	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109003764	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109003765	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
342109003766	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
342109003767	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK08742
342109003768	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
342109003769	inhibitor-cofactor binding pocket; inhibition site
342109003770	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109003771	catalytic residue [active]
342109003772	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
342109003773	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
342109003774	dimer interface [polypeptide binding]; other site
342109003775	ADP-ribose binding site [chemical binding]; other site
342109003776	active site
342109003777	nudix motif; other site
342109003778	metal binding site [ion binding]; metal-binding site
342109003779	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
342109003780	active site
342109003781	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
342109003782	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
342109003783	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
342109003784	Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
342109003785	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
342109003786	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
342109003787	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
342109003788	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
342109003789	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848
342109003790	lipoyl attachment site [posttranslational modification]; other site
342109003791	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
342109003792	Beta-lactamase; Region: Beta-lactamase; cl01009
342109003793	TLC ATP/ADP transporter; Region: TLC; cl03940
342109003794	Protein of unknown function (DUF1304); Region: DUF1304; cl01533
342109003795	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
342109003796	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
342109003797	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
342109003798	active site
342109003799	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
342109003800	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109003801	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
342109003802	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342109003803	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342109003804	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109003805	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109003806	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109003807	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
342109003808	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
342109003809	dimerization interface [polypeptide binding]; other site
342109003810	domain crossover interface; other site
342109003811	redox-dependent activation switch; other site
342109003812	Transglycosylase; Region: Transgly; cl07896
342109003813	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
342109003814	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
342109003815	Ligand binding site [chemical binding]; other site
342109003816	Putative Catalytic site [active]
342109003817	DXD motif; other site
342109003818	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623
342109003819	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
342109003820	Haemolysin-III related; Region: HlyIII; cl03831
342109003821	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
342109003822	RF3 subfamily.  Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria.  Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169
342109003823	G1 box; other site
342109003824	putative GEF interaction site [polypeptide binding]; other site
342109003825	GTP/Mg2+ binding site [chemical binding]; other site
342109003826	Switch I region; other site
342109003827	G2 box; other site
342109003828	G3 box; other site
342109003829	Switch II region; other site
342109003830	G4 box; other site
342109003831	G5 box; other site
342109003832	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
342109003833	Peptidase family M23; Region: Peptidase_M23; pfam01551
342109003834	homoserine O-acetyltransferase; Provisional; Region: PRK08775
342109003835	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109003836	cystathionine gamma-synthase; Provisional; Region: PRK08776
342109003837	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
342109003838	homodimer interface [polypeptide binding]; other site
342109003839	substrate-cofactor binding pocket; other site
342109003840	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109003841	catalytic residue [active]
342109003842	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
342109003843	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
342109003844	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
342109003845	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
342109003846	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
342109003847	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
342109003848	YceI-like domain; Region: YceI; cl01001
342109003849	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859
342109003850	YceI-like domain; Region: YceI; cl01001
342109003851	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
342109003852	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
342109003853	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109003854	dimer interface [polypeptide binding]; other site
342109003855	phosphorylation site [posttranslational modification]
342109003856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109003857	ATP binding site [chemical binding]; other site
342109003858	Mg2+ binding site [ion binding]; other site
342109003859	G-X-G motif; other site
342109003860	Response regulator receiver domain; Region: Response_reg; pfam00072
342109003861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109003862	active site
342109003863	phosphorylation site [posttranslational modification]
342109003864	intermolecular recognition site; other site
342109003865	dimerization interface [polypeptide binding]; other site
342109003866	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
342109003867	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
342109003868	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109003869	dimer interface [polypeptide binding]; other site
342109003870	phosphorylation site [posttranslational modification]
342109003871	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109003872	ATP binding site [chemical binding]; other site
342109003873	Mg2+ binding site [ion binding]; other site
342109003874	G-X-G motif; other site
342109003875	Response regulator receiver domain; Region: Response_reg; pfam00072
342109003876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109003877	active site
342109003878	phosphorylation site [posttranslational modification]
342109003879	intermolecular recognition site; other site
342109003880	dimerization interface [polypeptide binding]; other site
342109003881	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
342109003882	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
342109003883	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109003884	dimer interface [polypeptide binding]; other site
342109003885	phosphorylation site [posttranslational modification]
342109003886	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109003887	ATP binding site [chemical binding]; other site
342109003888	Mg2+ binding site [ion binding]; other site
342109003889	G-X-G motif; other site
342109003890	Response regulator receiver domain; Region: Response_reg; pfam00072
342109003891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109003892	active site
342109003893	phosphorylation site [posttranslational modification]
342109003894	intermolecular recognition site; other site
342109003895	dimerization interface [polypeptide binding]; other site
342109003896	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109003897	putative transposase OrfB; Reviewed; Region: PHA02517
342109003898	Integrase core domain; Region: rve; cl01316
342109003899	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109003900	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
342109003901	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
342109003902	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
342109003903	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
342109003904	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
342109003905	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109003906	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109003907	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
342109003908	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
342109003909	Domain of unknown function (DUF955); Region: DUF955; cl01076
342109003910	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
342109003911	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
342109003912	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
342109003913	tetrameric interface [polypeptide binding]; other site
342109003914	NAD binding site [chemical binding]; other site
342109003915	catalytic residues [active]
342109003916	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
342109003917	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
342109003918	active site
342109003919	enoyl-CoA hydratase; Provisional; Region: PRK09076
342109003920	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
342109003921	substrate binding site [chemical binding]; other site
342109003922	oxyanion hole (OAH) forming residues; other site
342109003923	trimer interface [polypeptide binding]; other site
342109003924	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
342109003925	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
342109003926	substrate binding site [chemical binding]; other site
342109003927	oxyanion hole (OAH) forming residues; other site
342109003928	trimer interface [polypeptide binding]; other site
342109003929	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109003930	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
342109003931	Cation efflux family; Region: Cation_efflux; cl00316
342109003932	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
342109003933	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
342109003934	substrate binding site [chemical binding]; other site
342109003935	oxyanion hole (OAH) forming residues; other site
342109003936	trimer interface [polypeptide binding]; other site
342109003937	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109003938	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
342109003939	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
342109003940	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342109003941	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
342109003942	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
342109003943	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
342109003944	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
342109003945	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
342109003946	protein binding site [polypeptide binding]; other site
342109003947	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
342109003948	protein binding site [polypeptide binding]; other site
342109003949	GTP-binding protein LepA; Provisional; Region: PRK05433
342109003950	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
342109003951	G1 box; other site
342109003952	putative GEF interaction site [polypeptide binding]; other site
342109003953	GTP/Mg2+ binding site [chemical binding]; other site
342109003954	Switch I region; other site
342109003955	G2 box; other site
342109003956	G3 box; other site
342109003957	Switch II region; other site
342109003958	G4 box; other site
342109003959	G5 box; other site
342109003960	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699
342109003961	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
342109003962	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
342109003963	signal peptidase I; Provisional; Region: PRK10861
342109003964	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
342109003965	Catalytic site [active]
342109003966	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
342109003967	ribonuclease III; Reviewed; Region: rnc; PRK00102
342109003968	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
342109003969	dimerization interface [polypeptide binding]; other site
342109003970	active site
342109003971	metal binding site [ion binding]; metal-binding site
342109003972	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
342109003973	dsRNA binding site [nucleotide binding]; other site
342109003974	GTPase Era; Reviewed; Region: era; PRK00089
342109003975	Era subfamily.  Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria.  It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163
342109003976	G1 box; other site
342109003977	GTP/Mg2+ binding site [chemical binding]; other site
342109003978	Switch I region; other site
342109003979	G2 box; other site
342109003980	Switch II region; other site
342109003981	G3 box; other site
342109003982	G4 box; other site
342109003983	G5 box; other site
342109003984	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098
342109003985	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
342109003986	Recombination protein O N terminal; Region: RecO_N; pfam11967
342109003987	Recombination protein O C terminal; Region: RecO_C; pfam02565
342109003988	Response regulator receiver domain; Region: Response_reg; pfam00072
342109003989	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109003990	active site
342109003991	phosphorylation site [posttranslational modification]
342109003992	intermolecular recognition site; other site
342109003993	dimerization interface [polypeptide binding]; other site
342109003994	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
342109003995	TRAM domain; Region: TRAM; cl01282
342109003996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109003997	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
342109003998	putative active site [active]
342109003999	putative metal binding residues [ion binding]; other site
342109004000	signature motif; other site
342109004001	putative dimer interface [polypeptide binding]; other site
342109004002	putative phosphate binding site [ion binding]; other site
342109004003	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109004004	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109004005	Transposase domain (DUF772); Region: DUF772; cl12084
342109004006	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
342109004007	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
342109004008	catalytic residues [active]
342109004009	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
342109004010	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
342109004011	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
342109004012	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
342109004013	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
342109004014	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
342109004015	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
342109004016	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
342109004017	DNA-binding site [nucleotide binding]; DNA binding site
342109004018	RNA-binding motif; other site
342109004019	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109004020	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
342109004021	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
342109004022	putative active site [active]
342109004023	putative metal binding site [ion binding]; other site
342109004024	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
342109004025	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342109004026	ATP binding site [chemical binding]; other site
342109004027	putative Mg++ binding site [ion binding]; other site
342109004028	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109004029	nucleotide binding region [chemical binding]; other site
342109004030	ATP-binding site [chemical binding]; other site
342109004031	DEAD/H associated; Region: DEAD_assoc; pfam08494
342109004032	ATP-dependent DNA ligase; Validated; Region: PRK09247
342109004033	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
342109004034	active site
342109004035	DNA binding site [nucleotide binding]
342109004036	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
342109004037	DNA binding site [nucleotide binding]
342109004038	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
342109004039	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
342109004040	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
342109004041	CHASE3 domain; Region: CHASE3; cl05000
342109004042	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109004043	metal binding site [ion binding]; metal-binding site
342109004044	active site
342109004045	I-site; other site
342109004046	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
342109004047	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
342109004048	dimer interface [polypeptide binding]; other site
342109004049	active site
342109004050	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
342109004051	putative active site [active]
342109004052	catalytic triad [active]
342109004053	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
342109004054	Autotransporter beta-domain; Region: Autotransporter; cl02365
342109004055	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
342109004056	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
342109004057	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
342109004058	NAD binding site [chemical binding]; other site
342109004059	Phe binding site; other site
342109004060	Protein of unknown function DUF45; Region: DUF45; cl00636
342109004061	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
342109004062	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
342109004063	Mechanosensitive ion channel; Region: MS_channel; pfam00924
342109004064	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109004065	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109004066	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109004067	putative chaperone; Provisional; Region: PRK11678
342109004068	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
342109004069	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109004070	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109004071	Cation efflux family; Region: Cation_efflux; cl00316
342109004072	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
342109004073	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
342109004074	PhnA protein; Region: PhnA; pfam03831
342109004075	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
342109004076	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
342109004077	FMN binding site [chemical binding]; other site
342109004078	active site
342109004079	substrate binding site [chemical binding]; other site
342109004080	catalytic residue [active]
342109004081	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
342109004082	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109004083	putative substrate translocation pore; other site
342109004084	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109004085	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109004086	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
342109004087	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
342109004088	2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834
342109004089	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
342109004090	Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791
342109004091	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
342109004092	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
342109004093	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004094	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004095	Predicted integral membrane protein [Function unknown]; Region: COG0392
342109004096	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
342109004097	Uncharacterized conserved protein [Function unknown]; Region: COG2898
342109004098	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
342109004099	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
342109004100	homotrimer interaction site [polypeptide binding]; other site
342109004101	putative active site [active]
342109004102	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
342109004103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109004104	S-adenosylmethionine binding site [chemical binding]; other site
342109004105	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
342109004106	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
342109004107	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
342109004108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109004109	S-adenosylmethionine binding site [chemical binding]; other site
342109004110	Protein of unknown function (DUF1365); Region: DUF1365; cl01388
342109004111	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
342109004112	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109004113	Fatty acid desaturase; Region: FA_desaturase; pfam00487
342109004114	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
342109004115	Di-iron ligands [ion binding]; other site
342109004116	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
342109004117	Anti-sigma-K factor rskA; Region: RskA; cl02208
342109004118	RNA polymerase sigma factor; Provisional; Region: PRK12534
342109004119	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342109004120	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
342109004121	DNA binding residues [nucleotide binding]
342109004122	ferredoxin; Provisional; Region: PRK08764
342109004123	Putative Fe-S cluster; Region: FeS; pfam04060
342109004124	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
342109004125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
342109004126	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
342109004127	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
342109004128	active site
342109004129	HIGH motif; other site
342109004130	KMSKS motif; other site
342109004131	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
342109004132	tRNA binding surface [nucleotide binding]; other site
342109004133	anticodon binding site; other site
342109004134	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
342109004135	putative tRNA-binding site [nucleotide binding]; other site
342109004136	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
342109004137	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
342109004138	active site
342109004139	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109004140	Integrase core domain; Region: rve; cl01316
342109004141	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
342109004142	Amino acid permease; Region: AA_permease; pfam00324
342109004143	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105
342109004144	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
342109004145	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
342109004146	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
342109004147	Protein of unknown function (DUF502); Region: DUF502; cl01107
342109004148	Transposase domain (DUF772); Region: DUF772; cl12084
342109004149	HSP20-like domain of unknown function (DUF1813); Region: DUF1813; cl07446
342109004150	Transposase domain (DUF772); Region: DUF772; cl12084
342109004151	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695
342109004152	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095
342109004153	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027
342109004154	ligand-binding site [chemical binding]; other site
342109004155	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109004156	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109004157	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
342109004158	PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907
342109004159	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109004160	Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863
342109004161	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
342109004162	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
342109004163	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
342109004164	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
342109004165	Walker A/P-loop; other site
342109004166	ATP binding site [chemical binding]; other site
342109004167	Q-loop/lid; other site
342109004168	ABC transporter signature motif; other site
342109004169	Walker B; other site
342109004170	D-loop; other site
342109004171	H-loop/switch region; other site
342109004172	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
342109004173	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109004174	N-terminal plug; other site
342109004175	ligand-binding site [chemical binding]; other site
342109004176	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
342109004177	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
342109004178	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
342109004179	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
342109004180	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
342109004181	generic binding surface II; other site
342109004182	generic binding surface I; other site
342109004183	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
342109004184	RNA/DNA hybrid binding site [nucleotide binding]; other site
342109004185	active site
342109004186	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
342109004187	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
342109004188	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
342109004189	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351
342109004190	active site
342109004191	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
342109004192	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
342109004193	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
342109004194	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352
342109004195	trimer interface [polypeptide binding]; other site
342109004196	active site
342109004197	UDP-GlcNAc binding site [chemical binding]; other site
342109004198	lipid binding site [chemical binding]; lipid-binding site
342109004199	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
342109004200	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
342109004201	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
342109004202	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
342109004203	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
342109004204	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
342109004205	Surface antigen; Region: Bac_surface_Ag; cl03097
342109004206	zinc metallopeptidase RseP; Provisional; Region: PRK10779
342109004207	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
342109004208	active site
342109004209	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
342109004210	protein binding site [polypeptide binding]; other site
342109004211	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
342109004212	putative substrate binding region [chemical binding]; other site
342109004213	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
342109004214	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
342109004215	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
342109004216	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
342109004217	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
342109004218	catalytic residue [active]
342109004219	putative FPP diphosphate  binding site; other site
342109004220	putative FPP binding hydrophobic cleft; other site
342109004221	dimer interface [polypeptide binding]; other site
342109004222	putative IPP diphosphate binding site; other site
342109004223	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
342109004224	hinge region; other site
342109004225	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254
342109004226	putative nucleotide binding site [chemical binding]; other site
342109004227	uridine monophosphate binding site [chemical binding]; other site
342109004228	homohexameric interface [polypeptide binding]; other site
342109004229	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
342109004230	elongation factor Ts; Provisional; Region: tsf; PRK09377
342109004231	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
342109004232	Elongation factor TS; Region: EF_TS; pfam00889
342109004233	Elongation factor TS; Region: EF_TS; pfam00889
342109004234	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
342109004235	rRNA interaction site [nucleotide binding]; other site
342109004236	S8 interaction site; other site
342109004237	putative laminin-1 binding site; other site
342109004238	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
342109004239	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
342109004240	Spore Coat Protein U domain; Region: SCPU; cl02253
342109004241	Spore Coat Protein U domain; Region: SCPU; cl02253
342109004242	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
342109004243	pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650
342109004244	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
342109004245	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
342109004246	Spore Coat Protein U domain; Region: SCPU; cl02253
342109004247	methionine aminopeptidase; Reviewed; Region: PRK07281
342109004248	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
342109004249	active site
342109004250	PII uridylyl-transferase; Provisional; Region: PRK04374
342109004251	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
342109004252	metal binding triad; other site
342109004253	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
342109004254	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
342109004255	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
342109004256	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
342109004257	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
342109004258	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350
342109004259	active site
342109004260	substrate binding site [chemical binding]; other site
342109004261	trimer interface [polypeptide binding]; other site
342109004262	CoA binding site [chemical binding]; other site
342109004263	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
342109004264	putative catalytic residues [active]
342109004265	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
342109004266	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
342109004267	metal binding site [ion binding]; metal-binding site
342109004268	dimer interface [polypeptide binding]; other site
342109004269	asparagine synthetase B; Provisional; Region: asnB; PRK09431
342109004270	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
342109004271	active site
342109004272	dimer interface [polypeptide binding]; other site
342109004273	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes...; Region: Asn_Synthase_B_C; cd01991
342109004274	Ligand Binding Site [chemical binding]; other site
342109004275	Molecular Tunnel; other site
342109004276	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
342109004277	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
342109004278	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109004279	N-terminal plug; other site
342109004280	ligand-binding site [chemical binding]; other site
342109004281	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
342109004282	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747
342109004283	active site
342109004284	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
342109004285	Ferritin-like domain; Region: Ferritin; pfam00210
342109004286	heme binding site [chemical binding]; other site
342109004287	ferroxidase pore; other site
342109004288	ferroxidase diiron center [ion binding]; other site
342109004289	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
342109004290	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
342109004291	CAP-like domain; other site
342109004292	Active site [active]
342109004293	primary dimer interface [polypeptide binding]; other site
342109004294	Cupin domain; Region: Cupin_2; cl09118
342109004295	Transcriptional regulators [Transcription]; Region: MarR; COG1846
342109004296	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109004297	NodT family; Region: outer_NodT; TIGR01845
342109004298	Outer membrane efflux protein; Region: OEP; pfam02321
342109004299	Outer membrane efflux protein; Region: OEP; pfam02321
342109004300	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
342109004301	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
342109004302	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109004303	putative substrate translocation pore; other site
342109004304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109004305	Beta-lactamase; Region: Beta-lactamase; cl01009
342109004306	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004307	Integrase core domain; Region: rve; cl01316
342109004308	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109004309	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109004310	Integrase core domain; Region: rve; cl01316
342109004311	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
342109004312	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
342109004313	TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007
342109004314	TPP-binding site; other site
342109004315	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
342109004316	PYR/PP interface [polypeptide binding]; other site
342109004317	dimer interface [polypeptide binding]; other site
342109004318	TPP binding site [chemical binding]; other site
342109004319	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
342109004320	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085
342109004321	active site
342109004322	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
342109004323	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
342109004324	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
342109004325	active site
342109004326	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
342109004327	Late embryogenesis abundant protein; Region: LEA_2; cl12118
342109004328	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
342109004329	SmpB-tmRNA interface; other site
342109004330	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
342109004331	putative coenzyme Q binding site [chemical binding]; other site
342109004332	Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096
342109004333	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
342109004334	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
342109004335	metal binding site 2 [ion binding]; metal-binding site
342109004336	putative DNA binding helix; other site
342109004337	metal binding site 1 [ion binding]; metal-binding site
342109004338	dimer interface [polypeptide binding]; other site
342109004339	structural Zn2+ binding site [ion binding]; other site
342109004340	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
342109004341	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
342109004342	Walker A/P-loop; other site
342109004343	ATP binding site [chemical binding]; other site
342109004344	Q-loop/lid; other site
342109004345	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
342109004346	ABC transporter signature motif; other site
342109004347	Walker B; other site
342109004348	D-loop; other site
342109004349	H-loop/switch region; other site
342109004350	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
342109004351	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109004352	HrcA protein C terminal domain; Region: HrcA; pfam01628
342109004353	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446
342109004354	dimer interface [polypeptide binding]; other site
342109004355	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
342109004356	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
342109004357	chaperone protein DnaJ; Provisional; Region: PRK10767
342109004358	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
342109004359	HSP70 interaction site [polypeptide binding]; other site
342109004360	DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908
342109004361	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
342109004362	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
342109004363	dimer interface [polypeptide binding]; other site
342109004364	pyridoxal binding site [chemical binding]; other site
342109004365	ATP binding site [chemical binding]; other site
342109004366	prephenate dehydrogenase; Provisional; Region: PRK08818
342109004367	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
342109004368	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109004369	Outer membrane efflux protein; Region: OEP; pfam02321
342109004370	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109004371	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109004372	dimerization interface [polypeptide binding]; other site
342109004373	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
342109004374	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
342109004375	MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249
342109004376	Walker A/P-loop; other site
342109004377	ATP binding site [chemical binding]; other site
342109004378	Q-loop/lid; other site
342109004379	ABC transporter signature motif; other site
342109004380	Walker B; other site
342109004381	D-loop; other site
342109004382	H-loop/switch region; other site
342109004383	Uncharacterized conserved protein [Function unknown]; Region: COG1739
342109004384	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
342109004385	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
342109004386	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
342109004387	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
342109004388	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109004389	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109004390	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
342109004391	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
342109004392	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
342109004393	E3 interaction surface; other site
342109004394	lipoyl attachment site [posttranslational modification]; other site
342109004395	e3 binding domain; Region: E3_binding; pfam02817
342109004396	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
342109004397	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
342109004398	TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016
342109004399	TPP-binding site [chemical binding]; other site
342109004400	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
342109004401	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342109004402	Coenzyme A binding pocket [chemical binding]; other site
342109004403	Cupin superfamily protein; Region: Cupin_4; pfam08007
342109004404	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
342109004405	protein binding site [polypeptide binding]; other site
342109004406	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
342109004407	adenylosuccinate lyase; Provisional; Region: PRK09285
342109004408	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
342109004409	tetramer interface [polypeptide binding]; other site
342109004410	active site
342109004411	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
342109004412	Domain of unknown function DUF21; Region: DUF21; pfam01595
342109004413	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
342109004414	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109004415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004417	Integrase core domain; Region: rve; cl01316
342109004418	fumarate hydratase; Reviewed; Region: fumC; PRK00485
342109004419	Class II fumarases; Region: Fumarase_classII; cd01362
342109004420	active site
342109004421	tetramer interface [polypeptide binding]; other site
342109004422	Protein of unknown function (DUF2884); Region: DUF2884; cl08135
342109004423	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
342109004424	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
342109004425	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
342109004426	Walker A/P-loop; other site
342109004427	ATP binding site [chemical binding]; other site
342109004428	Q-loop/lid; other site
342109004429	ABC transporter signature motif; other site
342109004430	Walker B; other site
342109004431	D-loop; other site
342109004432	H-loop/switch region; other site
342109004433	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
342109004434	DNA-binding site [nucleotide binding]; DNA binding site
342109004435	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340
342109004436	catalytic residues [active]
342109004437	dimer interface [polypeptide binding]; other site
342109004438	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
342109004439	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
342109004440	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
342109004441	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
342109004442	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
342109004443	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109004444	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
342109004445	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
342109004446	SlyX; Region: SlyX; cl01090
342109004447	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201
342109004448	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342109004449	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342109004450	DNA binding site [nucleotide binding]
342109004451	domain linker motif; other site
342109004452	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
342109004453	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
342109004454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
342109004455	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
342109004456	putative substrate binding site [chemical binding]; other site
342109004457	putative ATP binding site [chemical binding]; other site
342109004458	N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942
342109004459	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
342109004460	dimerization interface [polypeptide binding]; other site
342109004461	putative active cleft [active]
342109004462	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
342109004463	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
342109004464	substrate binding pocket [chemical binding]; other site
342109004465	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
342109004466	B12 binding site [chemical binding]; other site
342109004467	cobalt ligand [ion binding]; other site
342109004468	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
342109004469	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
342109004470	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105
342109004471	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
342109004472	dimerization interface [polypeptide binding]; other site
342109004473	putative DNA binding site [nucleotide binding]; other site
342109004474	putative Zn2+ binding site [ion binding]; other site
342109004475	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109004476	S-adenosylmethionine binding site [chemical binding]; other site
342109004477	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
342109004478	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
342109004479	active site
342109004480	PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...; Region: PAF_acetylesterase_like; cd01820
342109004481	active site
342109004482	catalytic triad [active]
342109004483	oxyanion hole [active]
342109004484	specificity pocket; other site
342109004485	PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...; Region: PAF_acetylesterase_like; cd01820
342109004486	active site
342109004487	catalytic triad [active]
342109004488	oxyanion hole [active]
342109004489	specificity pocket; other site
342109004490	ribonuclease R; Region: RNase_R; TIGR02063
342109004491	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
342109004492	RNB domain; Region: RNB; pfam00773
342109004493	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471
342109004494	RNA binding site [nucleotide binding]; other site
342109004495	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109004496	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004497	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004498	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
342109004499	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
342109004500	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
342109004501	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
342109004502	Transposase domain (DUF772); Region: DUF772; cl12084
342109004503	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109004504	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109004505	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004506	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004507	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109004508	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109004509	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109004510	Transposase domain (DUF772); Region: DUF772; cl12084
342109004511	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109004512	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109004513	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004514	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109004515	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109004516	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109004517	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109004518	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109004519	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109004520	Transposase, Mutator family; Region: Transposase_mut; pfam00872
342109004521	MULE transposase domain; Region: MULE; pfam10551
342109004522	Transposase domain (DUF772); Region: DUF772; cl12084
342109004523	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
342109004524	DNA-binding site [nucleotide binding]; DNA binding site
342109004525	RNA-binding motif; other site
342109004526	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109004527	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
342109004528	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109004529	Transposase domain (DUF772); Region: DUF772; cl12084
342109004530	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109004531	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109004532	Integrase core domain; Region: rve; cl01316
342109004533	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109004534	Gram-negative bacterial tonB protein; Region: TonB; cl10048
342109004535	Gram-negative bacterial tonB protein; Region: TonB; cl10048
342109004536	seryl-tRNA synthetase; Provisional; Region: PRK05431
342109004537	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
342109004538	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
342109004539	dimer interface [polypeptide binding]; other site
342109004540	active site
342109004541	motif 1; other site
342109004542	motif 2; other site
342109004543	motif 3; other site
342109004544	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109004545	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004546	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004547	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109004548	Transposase domain (DUF772); Region: DUF772; cl12084
342109004549	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109004550	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
342109004551	LysR family transcriptional regulator; Provisional; Region: PRK14997
342109004552	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109004553	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
342109004554	putative effector binding pocket; other site
342109004555	putative dimerization interface [polypeptide binding]; other site
342109004556	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004557	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004558	Phage protein; Region: DUF3653; pfam12375
342109004559	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004560	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004561	Integrase core domain; Region: rve; cl01316
342109004562	Transposase domain (DUF772); Region: DUF772; cl12084
342109004563	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004564	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004565	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004566	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109004567	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
342109004568	active site
342109004569	metal binding site [ion binding]; metal-binding site
342109004570	Peptidase C13 family; Region: Peptidase_C13; cl02159
342109004571	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
342109004572	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
342109004573	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
342109004574	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
342109004575	intersubunit interface [polypeptide binding]; other site
342109004576	active site
342109004577	Zn2+ binding site [ion binding]; other site
342109004578	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
342109004579	Amino acid permease; Region: AA_permease; pfam00324
342109004580	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
342109004581	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
342109004582	nudix motif; other site
342109004583	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
342109004584	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109004585	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
342109004586	L-serine binding site [chemical binding]; other site
342109004587	ACT domain interface; other site
342109004588	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
342109004589	FAD binding domain; Region: FAD_binding_4; pfam01565
342109004590	Protein of unknown function (DUF2388); Region: DUF2388; cl09731
342109004591	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
342109004592	Cytochrome C biogenesis protein; Region: CcmH; cl01179
342109004593	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
342109004594	catalytic residues [active]
342109004595	central insert; other site
342109004596	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
342109004597	CcmE; Region: CcmE; cl00994
342109004598	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
342109004599	CcmB protein; Region: CcmB; cl01016
342109004600	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13543
342109004601	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109004602	Walker A/P-loop; other site
342109004603	ATP binding site [chemical binding]; other site
342109004604	Q-loop/lid; other site
342109004605	ABC transporter signature motif; other site
342109004606	Walker B; other site
342109004607	D-loop; other site
342109004608	H-loop/switch region; other site
342109004609	methionine aminotransferase; Validated; Region: PRK09082
342109004610	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342109004611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109004612	homodimer interface [polypeptide binding]; other site
342109004613	catalytic residue [active]
342109004614	Predicted amidohydrolase [General function prediction only]; Region: COG0388
342109004615	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
342109004616	putative active site [active]
342109004617	catalytic triad [active]
342109004618	multimer interface [polypeptide binding]; other site
342109004619	dimer interface [polypeptide binding]; other site
342109004620	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109004621	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109004622	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
342109004623	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
342109004624	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
342109004625	RNA binding surface [nucleotide binding]; other site
342109004626	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
342109004627	active site
342109004628	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
342109004629	ScpA/B protein; Region: ScpA_ScpB; cl00598
342109004630	YCII-related domain; Region: YCII; cl00999
342109004631	BolA-like protein; Region: BolA; cl00386
342109004632	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342109004633	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342109004634	DNA binding site [nucleotide binding]
342109004635	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
342109004636	dimerization interface [polypeptide binding]; other site
342109004637	ligand binding site [chemical binding]; other site
342109004638	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109004639	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
342109004640	Uncharacterized protein conserved in bacteria (DUF2329); Region: DUF2329; pfam10091
342109004641	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
342109004642	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109004643	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
342109004644	dimer interface [polypeptide binding]; other site
342109004645	conserved gate region; other site
342109004646	putative PBP binding loops; other site
342109004647	ABC-ATPase subunit interface; other site
342109004648	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
342109004649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
342109004650	dimer interface [polypeptide binding]; other site
342109004651	conserved gate region; other site
342109004652	putative PBP binding loops; other site
342109004653	ABC-ATPase subunit interface; other site
342109004654	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
342109004655	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
342109004656	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
342109004657	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
342109004658	putative metal binding site [ion binding]; other site
342109004659	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
342109004660	TraB family; Region: TraB; cl12050
342109004661	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109004662	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
342109004663	N-carbamolyputrescine amidase; Region: PLN02747
342109004664	putative active site; other site
342109004665	catalytic triad [active]
342109004666	putative dimer interface [polypeptide binding]; other site
342109004667	agmatine deiminase; Region: agmatine_aguA; TIGR03380
342109004668	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
342109004669	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
342109004670	cytidylate kinase; Provisional; Region: cmk; PRK00023
342109004671	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
342109004672	CMP-binding site; other site
342109004673	The sites determining sugar specificity; other site
342109004674	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
342109004675	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
342109004676	RNA binding site [nucleotide binding]; other site
342109004677	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
342109004678	RNA binding site [nucleotide binding]; other site
342109004679	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
342109004680	RNA binding site [nucleotide binding]; other site
342109004681	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
342109004682	RNA binding site [nucleotide binding]; other site
342109004683	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
342109004684	RNA binding site [nucleotide binding]; other site
342109004685	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691
342109004686	RNA binding site [nucleotide binding]; other site
342109004687	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
342109004688	IHF dimer interface [polypeptide binding]; other site
342109004689	IHF - DNA interface [nucleotide binding]; other site
342109004690	tetratricopeptide repeat protein; Provisional; Region: PRK11788
342109004691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109004692	binding surface
342109004693	TPR motif; other site
342109004694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109004695	binding surface
342109004696	TPR motif; other site
342109004697	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine...; Region: GT_WbpL_WbcO_like; cd06854
342109004698	Mg++ binding site [ion binding]; other site
342109004699	putative catalytic motif [active]
342109004700	putative substrate binding site [chemical binding]; other site
342109004701	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
342109004702	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
342109004703	NAD(P) binding site [chemical binding]; other site
342109004704	homodimer interface [polypeptide binding]; other site
342109004705	substrate binding site [chemical binding]; other site
342109004706	active site
342109004707	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
342109004708	active site
342109004709	tetramer interface [polypeptide binding]; other site
342109004710	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
342109004711	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
342109004712	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109004713	Transposase domain (DUF772); Region: DUF772; cl12084
342109004714	Protein of unknown function (DUF1244); Region: DUF1244; cl01385
342109004715	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
342109004716	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
342109004717	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
342109004718	homodimer interface [polypeptide binding]; other site
342109004719	NADP binding site [chemical binding]; other site
342109004720	substrate binding site [chemical binding]; other site
342109004721	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
342109004722	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
342109004723	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
342109004724	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
342109004725	active site
342109004726	GMP synthase; Reviewed; Region: guaA; PRK00074
342109004727	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
342109004728	AMP/PPi binding site [chemical binding]; other site
342109004729	candidate oxyanion hole; other site
342109004730	catalytic triad [active]
342109004731	potential glutamine specificity residues [chemical binding]; other site
342109004732	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
342109004733	ATP Binding subdomain [chemical binding]; other site
342109004734	Ligand Binding sites [chemical binding]; other site
342109004735	Dimerization subdomain; other site
342109004736	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
342109004737	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
342109004738	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
342109004739	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
342109004740	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342109004741	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109004742	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
342109004743	dimerization interface [polypeptide binding]; other site
342109004744	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109004745	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
342109004746	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
342109004747	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109004748	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
342109004749	putative dimerization interface [polypeptide binding]; other site
342109004750	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109004751	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109004752	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
342109004753	Natural resistance-associated macrophage protein; Region: Nramp; cl00836
342109004754	manganese transport regulator MntR; Provisional; Region: PRK11050
342109004755	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109004756	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
342109004757	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
342109004758	nucleoside/Zn binding site; other site
342109004759	dimer interface [polypeptide binding]; other site
342109004760	catalytic motif [active]
342109004761	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
342109004762	putative active site [active]
342109004763	putative substrate binding site [chemical binding]; other site
342109004764	catalytic site [active]
342109004765	dimer interface [polypeptide binding]; other site
342109004766	Mechanosensitive ion channel; Region: MS_channel; pfam00924
342109004767	phosphoenolpyruvate synthase; Validated; Region: PRK06464
342109004768	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
342109004769	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
342109004770	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
342109004771	Domain of unknown function (DUF299); Region: DUF299; cl00780
342109004772	Protein of unknown function (DUF1249); Region: DUF1249; cl01223
342109004773	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
342109004774	putative active site [active]
342109004775	nucleotide binding site [chemical binding]; other site
342109004776	nudix motif; other site
342109004777	putative metal binding site [ion binding]; other site
342109004778	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109004779	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
342109004780	NAD(P) binding site [chemical binding]; other site
342109004781	active site
342109004782	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
342109004783	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914
342109004784	PhaC subunit; Region: PHA_synth_III_C; TIGR01836
342109004785	PspC domain; Region: PspC; cl00864
342109004786	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
342109004787	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
342109004788	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
342109004789	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
342109004790	Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525
342109004791	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685
342109004792	RNA binding site [nucleotide binding]; other site
342109004793	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109004794	Integrase core domain; Region: rve; cl01316
342109004795	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
342109004796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109004797	active site
342109004798	phosphorylation site [posttranslational modification]
342109004799	intermolecular recognition site; other site
342109004800	dimerization interface [polypeptide binding]; other site
342109004801	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
342109004802	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
342109004803	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109004804	ATP binding site [chemical binding]; other site
342109004805	Mg2+ binding site [ion binding]; other site
342109004806	G-X-G motif; other site
342109004807	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
342109004808	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
342109004809	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
342109004810	active site
342109004811	metabolite-proton symporter; Region: 2A0106; TIGR00883
342109004812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109004813	putative substrate translocation pore; other site
342109004814	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109004815	Integrase core domain; Region: rve; cl01316
342109004816	EamA-like transporter family; Region: EamA; cl01037
342109004817	EamA-like transporter family; Region: EamA; cl01037
342109004818	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
342109004819	FAD binding domain; Region: FAD_binding_4; pfam01565
342109004820	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
342109004821	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738
342109004822	quinone interaction residues [chemical binding]; other site
342109004823	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
342109004824	active site
342109004825	catalytic residues [active]
342109004826	FMN binding site [chemical binding]; other site
342109004827	substrate binding site [chemical binding]; other site
342109004828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109004829	S-adenosylmethionine binding site [chemical binding]; other site
342109004830	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
342109004831	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
342109004832	tetrameric interface [polypeptide binding]; other site
342109004833	NAD binding site [chemical binding]; other site
342109004834	catalytic residues [active]
342109004835	TspO/MBR family; Region: TspO_MBR; cl01379
342109004836	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
342109004837	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli AKI-...; Region: AAK_AK-HSDH; cd04257
342109004838	putative catalytic residues [active]
342109004839	putative nucleotide binding site [chemical binding]; other site
342109004840	putative aspartate binding site [chemical binding]; other site
342109004841	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
342109004842	dimer interface [polypeptide binding]; other site
342109004843	putative threonine allosteric regulatory site; other site
342109004844	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
342109004845	putative threonine allosteric regulatory site; other site
342109004846	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109004847	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
342109004848	homoserine kinase; Provisional; Region: PRK01212
342109004849	Tannase and feruloyl esterase; Region: Tannase; pfam07519
342109004850	EthD protein; Region: EthD; cl06234
342109004851	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
342109004852	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
342109004853	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109004854	catalytic residue [active]
342109004855	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
342109004856	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
342109004857	non-specific DNA interactions [nucleotide binding]; other site
342109004858	DNA binding site [nucleotide binding]
342109004859	sequence specific DNA binding site [nucleotide binding]; other site
342109004860	putative cAMP binding site [chemical binding]; other site
342109004861	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
342109004862	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
342109004863	dimer interface [polypeptide binding]; other site
342109004864	motif 1; other site
342109004865	active site
342109004866	motif 2; other site
342109004867	motif 3; other site
342109004868	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
342109004869	anticodon binding site; other site
342109004870	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109004871	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004872	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004873	Trp repressor protein; Region: Trp_repressor; cl01121
342109004874	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
342109004875	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109004876	HisG, C-terminal domain; Region: HisG_C; cl06867
342109004877	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
342109004878	E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572
342109004879	NAD binding site [chemical binding]; other site
342109004880	dimerization interface [polypeptide binding]; other site
342109004881	product binding site; other site
342109004882	substrate binding site [chemical binding]; other site
342109004883	zinc binding site [ion binding]; other site
342109004884	catalytic residues [active]
342109004885	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
342109004886	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342109004887	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109004888	homodimer interface [polypeptide binding]; other site
342109004889	catalytic residue [active]
342109004890	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
342109004891	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
342109004892	active site
342109004893	motif I; other site
342109004894	motif II; other site
342109004895	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
342109004896	putative active site pocket [active]
342109004897	4-fold oligomerization interface [polypeptide binding]; other site
342109004898	metal binding residues [ion binding]; metal-binding site
342109004899	3-fold/trimer interface [polypeptide binding]; other site
342109004900	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
342109004901	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
342109004902	putative active site [active]
342109004903	oxyanion strand; other site
342109004904	catalytic triad [active]
342109004905	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732
342109004906	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
342109004907	catalytic residues [active]
342109004908	Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107
342109004909	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731
342109004910	substrate binding site [chemical binding]; other site
342109004911	glutamase interaction surface [polypeptide binding]; other site
342109004912	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
342109004913	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
342109004914	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
342109004915	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004916	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004917	Phage protein; Region: DUF3653; pfam12375
342109004918	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004919	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004920	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
342109004921	Phage related protein; Region: DUF3693; pfam12472
342109004922	Replication initiation factor; Region: Rep_trans; pfam02486
342109004923	Helix-destabilising protein; Region: Phage_DNA_bind; pfam02303
342109004924	Zonular occludens toxin (Zot); Region: Zot; cl01706
342109004925	BCCT family transporter; Region: BCCT; cl00569
342109004926	Phage protein; Region: DUF3653; pfam12375
342109004927	TraX protein; Region: TraX; cl05434
342109004928	Zonular occludens toxin (Zot); Region: Zot; cl01706
342109004929	Helix-destabilising protein; Region: Phage_DNA_bind; pfam02303
342109004930	putative replication initiation protein; Region: PHA00330
342109004931	hypothetical protein; Region: PHA01083
342109004932	Phage related protein; Region: DUF3693; pfam12472
342109004933	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004934	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004935	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004936	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109004937	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004938	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004939	Phage protein; Region: DUF3653; pfam12375
342109004940	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004941	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004942	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004943	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004944	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109004945	Integrase core domain; Region: rve; cl01316
342109004946	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109004947	Integrase core domain; Region: rve; cl01316
342109004948	Transposase domain (DUF772); Region: DUF772; cl12084
342109004949	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109004950	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109004951	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109004952	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
342109004953	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
342109004954	RHS Repeat; Region: RHS_repeat; cl11982
342109004955	RHS Repeat; Region: RHS_repeat; cl11982
342109004956	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
342109004957	Transposase, Mutator family; Region: Transposase_mut; pfam00872
342109004958	MULE transposase domain; Region: MULE; pfam10551
342109004959	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109004960	Integrase core domain; Region: rve; cl01316
342109004961	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
342109004962	active site
342109004963	metal binding site [ion binding]; metal-binding site
342109004964	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
342109004965	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
342109004966	GIY-YIG catalytic domain; Region: GIY-YIG; cl01061
342109004967	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
342109004968	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
342109004969	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
342109004970	Low molecular weight phosphatase family; Region: LMWPc; cd00115
342109004971	Active site [active]
342109004972	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
342109004973	Ligand binding site [chemical binding]; other site
342109004974	oligomer interface [polypeptide binding]; other site
342109004975	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
342109004976	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
342109004977	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
342109004978	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
342109004979	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109004980	Walker A/P-loop; other site
342109004981	ATP binding site [chemical binding]; other site
342109004982	Q-loop/lid; other site
342109004983	ABC transporter signature motif; other site
342109004984	Walker B; other site
342109004985	D-loop; other site
342109004986	H-loop/switch region; other site
342109004987	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
342109004988	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
342109004989	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
342109004990	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
342109004991	Competence protein; Region: Competence; cl00471
342109004992	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
342109004993	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109004994	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109004995	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
342109004996	NAD(P) binding site [chemical binding]; other site
342109004997	active site
342109004998	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
342109004999	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
342109005000	Walker A/P-loop; other site
342109005001	ATP binding site [chemical binding]; other site
342109005002	Q-loop/lid; other site
342109005003	ABC transporter signature motif; other site
342109005004	Walker B; other site
342109005005	D-loop; other site
342109005006	H-loop/switch region; other site
342109005007	LolC/E family; Region: lolCE; TIGR02212
342109005008	FtsX-like permease family; Region: FtsX; pfam02687
342109005009	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
342109005010	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
342109005011	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
342109005012	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109005013	domain; Region: Succ_DH_flav_C; pfam02910
342109005014	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the...; Region: SQR_TypeC_SdhD_like; cd03495
342109005015	putative SdhC subunit interface [polypeptide binding]; other site
342109005016	putative proximal heme binding site [chemical binding]; other site
342109005017	putative Iron-sulfur protein interface [polypeptide binding]; other site
342109005018	putative proximal quinone binding site; other site
342109005019	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
342109005020	Iron-sulfur protein interface; other site
342109005021	proximal quinone binding site [chemical binding]; other site
342109005022	SdhD (CybS) interface [polypeptide binding]; other site
342109005023	proximal heme binding site [chemical binding]; other site
342109005024	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
342109005025	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
342109005026	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
342109005027	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
342109005028	Walker A/P-loop; other site
342109005029	ATP binding site [chemical binding]; other site
342109005030	Q-loop/lid; other site
342109005031	ABC transporter signature motif; other site
342109005032	Walker B; other site
342109005033	D-loop; other site
342109005034	H-loop/switch region; other site
342109005035	TOBE domain; Region: TOBE_2; cl01440
342109005036	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
342109005037	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
342109005038	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
342109005039	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
342109005040	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
342109005041	putative active site [active]
342109005042	Dehydratase family; Region: ILVD_EDD; cl00340
342109005043	6-phosphogluconate dehydratase; Region: edd; TIGR01196
342109005044	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
342109005045	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
342109005046	active site
342109005047	intersubunit interface [polypeptide binding]; other site
342109005048	catalytic residue [active]
342109005049	Transposase domain (DUF772); Region: DUF772; cl12084
342109005050	Prismane/CO dehydrogenase family; Region: Prismane; pfam03063
342109005051	response regulator; Provisional; Region: PRK13435
342109005052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
342109005053	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
342109005054	GAF domain; Region: GAF; cl00853
342109005055	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
342109005056	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342109005057	putative active site [active]
342109005058	heme pocket [chemical binding]; other site
342109005059	PAS domain S-box; Region: sensory_box; TIGR00229
342109005060	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342109005061	putative active site [active]
342109005062	heme pocket [chemical binding]; other site
342109005063	GAF domain; Region: GAF; cl00853
342109005064	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109005065	dimer interface [polypeptide binding]; other site
342109005066	phosphorylation site [posttranslational modification]
342109005067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109005068	ATP binding site [chemical binding]; other site
342109005069	Mg2+ binding site [ion binding]; other site
342109005070	G-X-G motif; other site
342109005071	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
342109005072	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109005073	active site
342109005074	phosphorylation site [posttranslational modification]
342109005075	intermolecular recognition site; other site
342109005076	dimerization interface [polypeptide binding]; other site
342109005077	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109005078	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109005079	CHASE3 domain; Region: CHASE3; cl05000
342109005080	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109005081	metal binding site [ion binding]; metal-binding site
342109005082	active site
342109005083	I-site; other site
342109005084	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109005085	metal binding site [ion binding]; metal-binding site
342109005086	active site
342109005087	I-site; other site
342109005088	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109005089	Integrase core domain; Region: rve; cl01316
342109005090	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109005091	Protein of unknown function (DUF3121); Region: DUF3121; cl11879
342109005092	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among Gram-...; Region: OMPLA; cd00541
342109005093	dimerization interface [polypeptide binding]; other site
342109005094	substrate binding site [chemical binding]; other site
342109005095	active site
342109005096	calcium binding site [ion binding]; other site
342109005097	GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188
342109005098	dimer interface [polypeptide binding]; other site
342109005099	N-terminal domain interface [polypeptide binding]; other site
342109005100	substrate binding pocket (H-site) [chemical binding]; other site
342109005101	putative fumarate hydratase; Provisional; Region: PRK15392
342109005102	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
342109005103	Fumarase C-terminus; Region: Fumerase_C; cl00795
342109005104	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
342109005105	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109005106	Walker A/P-loop; other site
342109005107	ATP binding site [chemical binding]; other site
342109005108	Q-loop/lid; other site
342109005109	ABC transporter signature motif; other site
342109005110	Walker B; other site
342109005111	D-loop; other site
342109005112	H-loop/switch region; other site
342109005113	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
342109005114	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
342109005115	FAD binding pocket [chemical binding]; other site
342109005116	FAD binding motif [chemical binding]; other site
342109005117	phosphate binding motif [ion binding]; other site
342109005118	beta-alpha-beta structure motif; other site
342109005119	NAD binding pocket [chemical binding]; other site
342109005120	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340
342109005121	catalytic residues [active]
342109005122	dimer interface [polypeptide binding]; other site
342109005123	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
342109005124	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
342109005125	Zn binding site [ion binding]; other site
342109005126	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109005127	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
342109005128	active site
342109005129	catalytic triad [active]
342109005130	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342109005131	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
342109005132	DNA binding residues [nucleotide binding]
342109005133	Anti-sigma-K factor rskA; Region: RskA; cl02208
342109005134	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109005135	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
342109005136	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109005137	Rhomboid family; Region: Rhomboid; cl11446
342109005138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
342109005139	Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_1_4; cd06241
342109005140	putative active site [active]
342109005141	Zn-binding site [ion binding]; other site
342109005142	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
342109005143	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
342109005144	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
342109005145	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109005146	GAF domain; Region: GAF; cl00853
342109005147	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
342109005148	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
342109005149	Sodium:solute symporter family; Region: SSF; cl00456
342109005150	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
342109005151	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
342109005152	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
342109005153	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
342109005154	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109005155	Phd_YefM; Region: PhdYeFM; cl09153
342109005156	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
342109005157	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
342109005158	active site
342109005159	dimer interface [polypeptide binding]; other site
342109005160	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
342109005161	dimer interface [polypeptide binding]; other site
342109005162	active site
342109005163	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
342109005164	tetramerization interface [polypeptide binding]; other site
342109005165	active site
342109005166	Pantoate-beta-alanine ligase; Region: PanC; cd00560
342109005167	pantoate--beta-alanine ligase; Region: panC; TIGR00018
342109005168	active site
342109005169	ATP-binding site [chemical binding]; other site
342109005170	pantoate-binding site; other site
342109005171	HXXH motif; other site
342109005172	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
342109005173	oligomerization interface [polypeptide binding]; other site
342109005174	active site
342109005175	metal binding site [ion binding]; metal-binding site
342109005176	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
342109005177	catalytic center binding site [active]
342109005178	ATP binding site [chemical binding]; other site
342109005179	poly(A) polymerase; Region: pcnB; TIGR01942
342109005180	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
342109005181	active site
342109005182	NTP binding site [chemical binding]; other site
342109005183	metal binding triad [ion binding]; metal-binding site
342109005184	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
342109005185	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
342109005186	Uncharacterized ACR, COG1469; Region: DUF198; cl00642
342109005187	Localisation of periplasmic protein complexes; Region: AMIN; pfam11741
342109005188	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
342109005189	active site
342109005190	metal binding site [ion binding]; metal-binding site
342109005191	Transposase domain (DUF772); Region: DUF772; cl12084
342109005192	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109005193	Transposase domain (DUF772); Region: DUF772; cl12084
342109005194	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
342109005195	putative active site [active]
342109005196	catalytic triad [active]
342109005197	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
342109005198	catalytic residues [active]
342109005199	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
342109005200	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185
342109005201	Autotransporter beta-domain; Region: Autotransporter; cl02365
342109005202	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
342109005203	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
342109005204	NodT family; Region: outer_NodT; TIGR01845
342109005205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109005206	dimer interface [polypeptide binding]; other site
342109005207	phosphorylation site [posttranslational modification]
342109005208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109005209	ATP binding site [chemical binding]; other site
342109005210	Mg2+ binding site [ion binding]; other site
342109005211	G-X-G motif; other site
342109005212	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
342109005213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109005214	active site
342109005215	phosphorylation site [posttranslational modification]
342109005216	intermolecular recognition site; other site
342109005217	dimerization interface [polypeptide binding]; other site
342109005218	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
342109005219	DNA binding residues [nucleotide binding]
342109005220	dimerization interface [polypeptide binding]; other site
342109005221	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
342109005222	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185
342109005223	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
342109005224	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
342109005225	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
342109005226	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185
342109005227	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185
342109005228	Autotransporter beta-domain; Region: Autotransporter; cl02365
342109005229	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109005230	Integrase core domain; Region: rve; cl01316
342109005231	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109005232	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
342109005233	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556
342109005234	hinge; other site
342109005235	active site
342109005236	Chorismate mutase type II; Region: CM_2; cl00693
342109005237	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
342109005238	Prephenate dehydratase; Region: PDT; pfam00800
342109005239	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
342109005240	putative L-Phe binding site [chemical binding]; other site
342109005241	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109005242	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109005243	catalytic residue [active]
342109005244	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
342109005245	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
342109005246	Moco binding site; other site
342109005247	metal coordination site [ion binding]; other site
342109005248	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
342109005249	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
342109005250	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
342109005251	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
342109005252	Restriction endonuclease; Region: Mrr_cat; cl00747
342109005253	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
342109005254	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
342109005255	DNA-binding site [nucleotide binding]; DNA binding site
342109005256	UTRA domain; Region: UTRA; cl06649
342109005257	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
342109005258	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
342109005259	active site
342109005260	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
342109005261	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296
342109005262	active site
342109005263	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
342109005264	tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832
342109005265	active sites [active]
342109005266	tetramer interface [polypeptide binding]; other site
342109005267	N-formylglutamate amidohydrolase; Region: FGase; cl01522
342109005268	urocanate hydratase; Provisional; Region: PRK05414
342109005269	urocanate hydratase; Region: hutU; TIGR01228
342109005270	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
342109005271	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109005272	DNA gyrase subunit A; Validated; Region: PRK05560
342109005273	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
342109005274	CAP-like domain; other site
342109005275	Active site [active]
342109005276	primary dimer interface [polypeptide binding]; other site
342109005277	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
342109005278	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
342109005279	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
342109005280	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
342109005281	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
342109005282	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
342109005283	Initiation factor 2 subunit family; Region: IF-2B; pfam01008
342109005284	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
342109005285	lysyl-tRNA synthetase-like protein GenX; Region: genX; TIGR00462
342109005286	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
342109005287	motif 1; other site
342109005288	dimer interface [polypeptide binding]; other site
342109005289	active site
342109005290	motif 2; other site
342109005291	motif 3; other site
342109005292	Ligase N family; Region: LIGANc; smart00532
342109005293	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
342109005294	nucleotide binding pocket [chemical binding]; other site
342109005295	K-X-D-G motif; other site
342109005296	catalytic site [active]
342109005297	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
342109005298	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
342109005299	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
342109005300	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
342109005301	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027
342109005302	Dimer interface [polypeptide binding]; other site
342109005303	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
342109005304	FtsZ protein binding site [polypeptide binding]; other site
342109005305	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
342109005306	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
342109005307	Walker A/P-loop; other site
342109005308	ATP binding site [chemical binding]; other site
342109005309	Q-loop/lid; other site
342109005310	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
342109005311	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
342109005312	ABC transporter signature motif; other site
342109005313	Walker B; other site
342109005314	D-loop; other site
342109005315	H-loop/switch region; other site
342109005316	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
342109005317	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
342109005318	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
342109005319	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
342109005320	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
342109005321	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
342109005322	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
342109005323	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318
342109005324	putative dimer interface [polypeptide binding]; other site
342109005325	putative anticodon binding site; other site
342109005326	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776
342109005327	homodimer interface [polypeptide binding]; other site
342109005328	motif 1; other site
342109005329	motif 2; other site
342109005330	active site
342109005331	motif 3; other site
342109005332	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
342109005333	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
342109005334	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
342109005335	active site clefts [active]
342109005336	zinc binding site [ion binding]; other site
342109005337	dimer interface [polypeptide binding]; other site
342109005338	Cupin domain; Region: Cupin_2; cl09118
342109005339	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
342109005340	kynureninase; Region: kynureninase; TIGR01814
342109005341	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109005342	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109005343	catalytic residue [active]
342109005344	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
342109005345	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109005346	exonuclease I; Provisional; Region: sbcB; PRK11779
342109005347	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
342109005348	active site
342109005349	substrate binding site [chemical binding]; other site
342109005350	catalytic site [active]
342109005351	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
342109005352	Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374
342109005353	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
342109005354	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
342109005355	active site
342109005356	catalytic tetrad [active]
342109005357	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
342109005358	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
342109005359	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
342109005360	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
342109005361	THUMP domain; Region: THUMP; cl12076
342109005362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109005363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109005364	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
342109005365	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109005366	Walker A/P-loop; other site
342109005367	ATP binding site [chemical binding]; other site
342109005368	Q-loop/lid; other site
342109005369	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
342109005370	ABC transporter signature motif; other site
342109005371	Walker B; other site
342109005372	D-loop; other site
342109005373	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109005374	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
342109005375	MOSC domain; Region: MOSC; pfam03473
342109005376	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
342109005377	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
342109005378	substrate binding site [chemical binding]; other site
342109005379	Protein of unknown function (DUF1684); Region: DUF1684; cl01327
342109005380	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448
342109005381	active site residue [active]
342109005382	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
342109005383	active site residue [active]
342109005384	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
342109005385	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
342109005386	putative active site [active]
342109005387	putative CoA binding site [chemical binding]; other site
342109005388	nudix motif; other site
342109005389	metal binding site [ion binding]; metal-binding site
342109005390	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
342109005391	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
342109005392	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
342109005393	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
342109005394	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
342109005395	substrate binding site [chemical binding]; other site
342109005396	oxyanion hole (OAH) forming residues; other site
342109005397	trimer interface [polypeptide binding]; other site
342109005398	endonuclease III; Provisional; Region: PRK10702
342109005399	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
342109005400	minor groove reading motif; other site
342109005401	helix-hairpin-helix signature motif; other site
342109005402	substrate binding pocket [chemical binding]; other site
342109005403	active site
342109005404	Sulfate transporter family; Region: Sulfate_transp; cl00967
342109005405	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
342109005406	dimer interface [polypeptide binding]; other site
342109005407	active site clefts [active]
342109005408	zinc binding site [ion binding]; other site
342109005409	Transposase domain (DUF772); Region: DUF772; cl12084
342109005410	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109005411	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109005412	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109005413	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109005414	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109005415	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
342109005416	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109005417	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109005418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
342109005419	dimer interface [polypeptide binding]; other site
342109005420	conserved gate region; other site
342109005421	putative PBP binding loops; other site
342109005422	ABC-ATPase subunit interface; other site
342109005423	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
342109005424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
342109005425	dimer interface [polypeptide binding]; other site
342109005426	conserved gate region; other site
342109005427	putative PBP binding loops; other site
342109005428	ABC-ATPase subunit interface; other site
342109005429	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
342109005430	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
342109005431	Walker A/P-loop; other site
342109005432	ATP binding site [chemical binding]; other site
342109005433	Q-loop/lid; other site
342109005434	ABC transporter signature motif; other site
342109005435	Walker B; other site
342109005436	D-loop; other site
342109005437	H-loop/switch region; other site
342109005438	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
342109005439	PhoU domain; Region: PhoU; pfam01895
342109005440	PhoU domain; Region: PhoU; pfam01895
342109005441	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
342109005442	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
342109005443	dimer interface [polypeptide binding]; other site
342109005444	putative active site [active]
342109005445	putative substrate binding site [chemical binding]; other site
342109005446	catalytic site [active]
342109005447	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109005448	Transposase domain (DUF772); Region: DUF772; cl12084
342109005449	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109005450	Transposase, Mutator family; Region: Transposase_mut; pfam00872
342109005451	MULE transposase domain; Region: MULE; pfam10551
342109005452	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109005453	Transposase domain (DUF772); Region: DUF772; cl12084
342109005454	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109005455	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
342109005456	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
342109005457	Protein export membrane protein; Region: SecD_SecF; cl14618
342109005458	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
342109005459	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
342109005460	Protein export membrane protein; Region: SecD_SecF; cl14618
342109005461	Preprotein translocase subunit; Region: YajC; cl00806
342109005462	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
342109005463	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
342109005464	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
342109005465	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
342109005466	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109005467	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109005468	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
342109005469	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109005470	catalytic residue [active]
342109005471	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
342109005472	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
342109005473	Transposase domain (DUF772); Region: DUF772; cl12084
342109005474	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247
342109005475	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109005476	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109005477	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109005478	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109005479	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
342109005480	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109005481	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109005482	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109005483	Integrase core domain; Region: rve; cl01316
342109005484	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
342109005485	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
342109005486	hypothetical protein; Provisional; Region: PRK13795
342109005487	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
342109005488	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
342109005489	active site
342109005490	(T/H)XGH motif; other site
342109005491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109005492	S-adenosylmethionine binding site [chemical binding]; other site
342109005493	heat shock protein 90; Provisional; Region: PRK05218
342109005494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109005495	ATP binding site [chemical binding]; other site
342109005496	Mg2+ binding site [ion binding]; other site
342109005497	G-X-G motif; other site
342109005498	Integrase core domain; Region: rve; cl01316
342109005499	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109005500	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109005501	molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762
342109005502	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
342109005503	active site residue [active]
342109005504	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757
342109005505	ATP binding site [chemical binding]; other site
342109005506	substrate interface [chemical binding]; other site
342109005507	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109005508	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109005509	Transposase domain (DUF772); Region: DUF772; cl12084
342109005510	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109005511	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109005512	Transposase domain (DUF772); Region: DUF772; cl12084
342109005513	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109005514	Integrase core domain; Region: rve; cl01316
342109005515	Transposase domain (DUF772); Region: DUF772; cl12084
342109005516	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109005517	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109005518	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
342109005519	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
342109005520	dimer interface [polypeptide binding]; other site
342109005521	putative functional site; other site
342109005522	putative MPT binding site; other site
342109005523	GTP-binding protein Der; Reviewed; Region: PRK00093
342109005524	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894
342109005525	G1 box; other site
342109005526	GTP/Mg2+ binding site [chemical binding]; other site
342109005527	Switch I region; other site
342109005528	G2 box; other site
342109005529	Switch II region; other site
342109005530	G3 box; other site
342109005531	G4 box; other site
342109005532	G5 box; other site
342109005533	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895
342109005534	G1 box; other site
342109005535	GTP/Mg2+ binding site [chemical binding]; other site
342109005536	Switch I region; other site
342109005537	G2 box; other site
342109005538	G3 box; other site
342109005539	Switch II region; other site
342109005540	G4 box; other site
342109005541	G5 box; other site
342109005542	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
342109005543	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
342109005544	Trp docking motif; other site
342109005545	active site
342109005546	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
342109005547	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
342109005548	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
342109005549	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
342109005550	cytoskeletal protein RodZ; Provisional; Region: PRK10856
342109005551	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109005552	binding surface
342109005553	TPR motif; other site
342109005554	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109005555	binding surface
342109005556	TPR motif; other site
342109005557	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
342109005558	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
342109005559	FeS/SAM binding site; other site
342109005560	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
342109005561	active site
342109005562	multimer interface [polypeptide binding]; other site
342109005563	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342109005564	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342109005565	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
342109005566	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109005567	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
342109005568	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
342109005569	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
342109005570	substrate binding site [chemical binding]; other site
342109005571	oxyanion hole (OAH) forming residues; other site
342109005572	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
342109005573	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
342109005574	dimer interface [polypeptide binding]; other site
342109005575	active site
342109005576	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
342109005577	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
342109005578	putative Cl- selectivity filter; other site
342109005579	putative pore gating glutamate residue; other site
342109005580	CrcB-like protein; Region: CRCB; cl09114
342109005581	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
342109005582	recombination factor protein RarA; Reviewed; Region: PRK13342
342109005583	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109005584	Walker A motif; other site
342109005585	ATP binding site [chemical binding]; other site
342109005586	Walker B motif; other site
342109005587	arginine finger; other site
342109005588	MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440
342109005589	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
342109005590	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
342109005591	Domain of Unknown Function with PDB structure; Region: DUF3857; pfam12969
342109005592	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
342109005593	DNA translocase FtsK; Provisional; Region: PRK10263
342109005594	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
342109005595	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109005596	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
342109005597	thioredoxin reductase; Provisional; Region: PRK10262
342109005598	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109005599	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109005600	FemAB family; Region: FemAB; cl11444
342109005601	Protein of unknown function, DUF482; Region: DUF482; pfam04339
342109005602	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109005603	NAD(P) binding site [chemical binding]; other site
342109005604	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109005605	Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006
342109005606	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
342109005607	rRNA binding site [nucleotide binding]; other site
342109005608	predicted 30S ribosome binding site; other site
342109005609	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
342109005610	Clp amino terminal domain; Region: Clp_N; pfam02861
342109005611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109005612	Walker A motif; other site
342109005613	ATP binding site [chemical binding]; other site
342109005614	Walker B motif; other site
342109005615	arginine finger; other site
342109005616	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109005617	Walker A motif; other site
342109005618	ATP binding site [chemical binding]; other site
342109005619	Walker B motif; other site
342109005620	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
342109005621	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
342109005622	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_2; cd03675
342109005623	nudix motif; other site
342109005624	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
342109005625	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998
342109005626	Protein of unknown function (DUF489); Region: DUF489; cl01097
342109005627	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
342109005628	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
342109005629	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342109005630	PAS fold; Region: PAS_3; pfam08447
342109005631	putative active site [active]
342109005632	heme pocket [chemical binding]; other site
342109005633	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109005634	metal binding site [ion binding]; metal-binding site
342109005635	active site
342109005636	I-site; other site
342109005637	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
342109005638	PAS fold; Region: PAS_4; pfam08448
342109005639	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
342109005640	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
342109005641	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342109005642	putative active site [active]
342109005643	heme pocket [chemical binding]; other site
342109005644	Histidine kinase; Region: HisKA_3; pfam07730
342109005645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109005646	ATP binding site [chemical binding]; other site
342109005647	Mg2+ binding site [ion binding]; other site
342109005648	G-X-G motif; other site
342109005649	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109005650	metal binding site [ion binding]; metal-binding site
342109005651	active site
342109005652	I-site; other site
342109005653	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
342109005654	Response regulator receiver domain; Region: Response_reg; pfam00072
342109005655	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109005656	active site
342109005657	phosphorylation site [posttranslational modification]
342109005658	intermolecular recognition site; other site
342109005659	dimerization interface [polypeptide binding]; other site
342109005660	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
342109005661	Mediator complex subunit 30; Region: Med30; pfam11315
342109005662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109005663	ATP binding site [chemical binding]; other site
342109005664	Mg2+ binding site [ion binding]; other site
342109005665	G-X-G motif; other site
342109005666	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
342109005667	SAF domain; Region: SAF; cl00555
342109005668	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
342109005669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109005670	active site
342109005671	phosphorylation site [posttranslational modification]
342109005672	intermolecular recognition site; other site
342109005673	dimerization interface [polypeptide binding]; other site
342109005674	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
342109005675	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12620
342109005676	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12629
342109005677	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
342109005678	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
342109005679	Flagellar hook capping protein; Region: FlgD; cl04347
342109005680	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
342109005681	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
342109005682	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
342109005683	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
342109005684	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
342109005685	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
342109005686	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
342109005687	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
342109005688	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
342109005689	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
342109005690	Flagellar L-ring protein; Region: FlgH; cl00905
342109005691	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
342109005692	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
342109005693	flagellar rod assembly protein/muramidase FlgJ; Reviewed; Region: flgJ; PRK12711
342109005694	Rod binding protein; Region: Rod-binding; cl01626
342109005695	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
342109005696	flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12714
342109005697	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
342109005698	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
342109005699	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
342109005700	flagellin; Reviewed; Region: PRK08869
342109005701	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
342109005702	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
342109005703	flagellar capping protein; Reviewed; Region: fliD; PRK08032
342109005704	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
342109005705	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
342109005706	Flagellar protein FliS; Region: FliS; cl00654
342109005707	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
342109005708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109005709	active site
342109005710	phosphorylation site [posttranslational modification]
342109005711	intermolecular recognition site; other site
342109005712	dimerization interface [polypeptide binding]; other site
342109005713	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
342109005714	DNA binding residues [nucleotide binding]
342109005715	dimerization interface [polypeptide binding]; other site
342109005716	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
342109005717	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
342109005718	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
342109005719	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
342109005720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109005721	active site
342109005722	phosphorylation site [posttranslational modification]
342109005723	intermolecular recognition site; other site
342109005724	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
342109005725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
342109005726	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109005727	Walker A motif; other site
342109005728	ATP binding site [chemical binding]; other site
342109005729	Walker B motif; other site
342109005730	arginine finger; other site
342109005731	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
342109005732	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
342109005733	inhibitor-cofactor binding pocket; inhibition site
342109005734	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109005735	catalytic residue [active]
342109005736	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
342109005737	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
342109005738	dimer interface [polypeptide binding]; other site
342109005739	active site
342109005740	CoA binding pocket [chemical binding]; other site
342109005741	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
342109005742	classical (c) SDRs; Region: SDR_c; cd05233
342109005743	NAD(P) binding site [chemical binding]; other site
342109005744	active site
342109005745	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
342109005746	classical (c) SDRs; Region: SDR_c; cd05233
342109005747	NAD(P) binding site [chemical binding]; other site
342109005748	active site
342109005749	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
342109005750	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
342109005751	putative trimer interface [polypeptide binding]; other site
342109005752	putative CoA binding site [chemical binding]; other site
342109005753	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
342109005754	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
342109005755	[2Fe-2S] cluster binding site [ion binding]; other site
342109005756	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
342109005757	alpha subunit interface [polypeptide binding]; other site
342109005758	active site
342109005759	substrate binding site [chemical binding]; other site
342109005760	Fe binding site [ion binding]; other site
342109005761	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
342109005762	putative trimer interface [polypeptide binding]; other site
342109005763	putative CoA binding site [chemical binding]; other site
342109005764	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109005765	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
342109005766	active site
342109005767	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
342109005768	active site
342109005769	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
342109005770	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
342109005771	flagellar MS-ring protein; Reviewed; Region: fliF; PRK12800
342109005772	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
342109005773	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
342109005774	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
342109005775	FliG C-terminal domain; Region: FliG_C; pfam01706
342109005776	Flagellar assembly protein FliH; Region: FliH; pfam02108
342109005777	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
342109005778	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109005779	Walker A motif; other site
342109005780	ATP binding site [chemical binding]; other site
342109005781	Walker B motif; other site
342109005782	Flagellar FliJ protein; Region: FliJ; cl09161
342109005783	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
342109005784	Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669
342109005785	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
342109005786	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
342109005787	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
342109005788	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
342109005789	FliP family; Region: FliP; cl00593
342109005790	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
342109005791	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
342109005792	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
342109005793	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
342109005794	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
342109005795	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109005796	metal binding site [ion binding]; metal-binding site
342109005797	active site
342109005798	I-site; other site
342109005799	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
342109005800	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
342109005801	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
342109005802	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109005803	metal binding site [ion binding]; metal-binding site
342109005804	active site
342109005805	I-site; other site
342109005806	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
342109005807	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
342109005808	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109005809	metal binding site [ion binding]; metal-binding site
342109005810	active site
342109005811	I-site; other site
342109005812	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
342109005813	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
342109005814	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
342109005815	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
342109005816	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
342109005817	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12727
342109005818	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
342109005819	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
342109005820	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
342109005821	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
342109005822	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342109005823	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
342109005824	DNA binding residues [nucleotide binding]
342109005825	Response regulator receiver domain; Region: Response_reg; pfam00072
342109005826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109005827	active site
342109005828	phosphorylation site [posttranslational modification]
342109005829	intermolecular recognition site; other site
342109005830	dimerization interface [polypeptide binding]; other site
342109005831	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
342109005832	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
342109005833	putative binding surface; other site
342109005834	active site
342109005835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109005836	ATP binding site [chemical binding]; other site
342109005837	Mg2+ binding site [ion binding]; other site
342109005838	G-X-G motif; other site
342109005839	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
342109005840	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109005841	Integrase core domain; Region: rve; cl01316
342109005842	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109005843	Transposase domain (DUF772); Region: DUF772; cl12084
342109005844	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109005845	RHS Repeat; Region: RHS_repeat; cl11982
342109005846	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
342109005847	RHS Repeat; Region: RHS_repeat; cl11982
342109005848	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
342109005849	NlpC/P60 family; Region: NLPC_P60; cl11438
342109005850	Transposase domain (DUF772); Region: DUF772; cl12084
342109005851	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109005852	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109005853	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
342109005854	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
342109005855	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
342109005856	Protein export membrane protein; Region: SecD_SecF; cl14618
342109005857	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
342109005858	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404
342109005859	Cytochrome c; Region: Cytochrom_C; cl11414
342109005860	Cytochrome c; Region: Cytochrom_C; cl11414
342109005861	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109005862	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109005863	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109005864	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
342109005865	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109005866	Walker A/P-loop; other site
342109005867	ATP binding site [chemical binding]; other site
342109005868	Q-loop/lid; other site
342109005869	ABC transporter signature motif; other site
342109005870	Walker B; other site
342109005871	D-loop; other site
342109005872	H-loop/switch region; other site
342109005873	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
342109005874	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
342109005875	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109005876	Walker A/P-loop; other site
342109005877	ATP binding site [chemical binding]; other site
342109005878	Q-loop/lid; other site
342109005879	ABC transporter signature motif; other site
342109005880	Walker B; other site
342109005881	D-loop; other site
342109005882	H-loop/switch region; other site
342109005883	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109005884	Integrase core domain; Region: rve; cl01316
342109005885	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
342109005886	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109005887	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109005888	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
342109005889	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
342109005890	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109005891	putative substrate translocation pore; other site
342109005892	Predicted acyl esterases [General function prediction only]; Region: COG2936
342109005893	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
342109005894	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
342109005895	putative catalytic cysteine [active]
342109005896	gamma-glutamyl kinase; Provisional; Region: PRK05429
342109005897	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
342109005898	nucleotide binding site [chemical binding]; other site
342109005899	substrate binding site [chemical binding]; other site
342109005900	PUA domain; Region: PUA; cl00607
342109005901	YCII-related domain; Region: YCII; cl00999
342109005902	Cupin domain; Region: Cupin_2; cl09118
342109005903	argininosuccinate lyase; Provisional; Region: PRK00855
342109005904	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
342109005905	active sites [active]
342109005906	tetramer interface [polypeptide binding]; other site
342109005907	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
342109005908	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109005909	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
342109005910	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109005911	acetylglutamate kinase; Provisional; Region: PRK04531
342109005912	AAK_NAGK-fArgBP: N-Acetyl-L-glutamate kinase (NAGK) of the fungal arginine-biosynthetic pathway (fArgBP). The nuclear-encoded, mitochondrial polyprotein precursor with an N-terminal NAGK (ArgB) domain (this CD), a central DUF619 domain, and a C-...; Region: AAK_NAGK-fArgBP; cd04252
342109005913	putative nucleotide binding site [chemical binding]; other site
342109005914	putative N-acetyl-L-glutamate binding site [chemical binding]; other site
342109005915	DUF619 domain of various N-acetylglutamate Synthases of the fungal arginine-biosynthetic pathway and urea cycle found in humans and fish; Region: DUF619-NAGS; cd04264
342109005916	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
342109005917	M28, and M42; Region: Zinc_peptidase_like; cl14876
342109005918	metal binding site [ion binding]; metal-binding site
342109005919	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109005920	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
342109005921	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
342109005922	ANP binding site [chemical binding]; other site
342109005923	Substrate Binding Site II [chemical binding]; other site
342109005924	Substrate Binding Site I [chemical binding]; other site
342109005925	N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523
342109005926	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
342109005927	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
342109005928	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
342109005929	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
342109005930	active site
342109005931	HIGH motif; other site
342109005932	nucleotide binding site [chemical binding]; other site
342109005933	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
342109005934	KMSKS motif; other site
342109005935	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
342109005936	tRNA binding surface [nucleotide binding]; other site
342109005937	anticodon binding site; other site
342109005938	Fe-S metabolism associated domain; Region: SufE; cl00951
342109005939	H+ Antiporter protein; Region: 2A0121; TIGR00900
342109005940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109005941	putative substrate translocation pore; other site
342109005942	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
342109005943	active site triad [active]
342109005944	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
342109005945	Domain of unknown function DUF37; Region: DUF37; cl00506
342109005946	dihydroorotase; Reviewed; Region: PRK09236
342109005947	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
342109005948	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
342109005949	active site
342109005950	Peptidase family M23; Region: Peptidase_M23; pfam01551
342109005951	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
342109005952	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109005953	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109005954	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
342109005955	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109005956	Integrase core domain; Region: rve; cl01316
342109005957	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109005958	Transposase domain (DUF772); Region: DUF772; cl12084
342109005959	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109005960	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109005961	Pectinesterase; Region: Pectinesterase; cl01911
342109005962	Pectin methylesterase [Carbohydrate transport and metabolism]; Region: PemB; COG4677
342109005963	Integrase core domain; Region: rve; cl01316
342109005964	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
342109005965	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
342109005966	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
342109005967	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
342109005968	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
342109005969	motif II; other site
342109005970	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
342109005971	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109005972	S-adenosylmethionine binding site [chemical binding]; other site
342109005973	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
342109005974	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
342109005975	active site
342109005976	putative substrate binding pocket [chemical binding]; other site
342109005977	elongation factor P; Validated; Region: PRK00529
342109005978	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
342109005979	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
342109005980	RNA binding site [nucleotide binding]; other site
342109005981	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
342109005982	RNA binding site [nucleotide binding]; other site
342109005983	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
342109005984	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
342109005985	FeS/SAM binding site; other site
342109005986	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109005987	metal binding site [ion binding]; metal-binding site
342109005988	active site
342109005989	I-site; other site
342109005990	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
342109005991	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109005992	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
342109005993	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
342109005994	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
342109005995	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
342109005996	active site
342109005997	dimerization interface [polypeptide binding]; other site
342109005998	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
342109005999	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
342109006000	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
342109006001	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a...; Region: RNase_Sa; cd00607
342109006002	active site
342109006003	barstar interaction site; other site
342109006004	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
342109006005	putative RNAase interaction site [polypeptide binding]; other site
342109006006	ABC transporter ATPase component; Reviewed; Region: PRK11147
342109006007	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109006008	Walker A/P-loop; other site
342109006009	ATP binding site [chemical binding]; other site
342109006010	Q-loop/lid; other site
342109006011	ABC transporter signature motif; other site
342109006012	Walker B; other site
342109006013	D-loop; other site
342109006014	H-loop/switch region; other site
342109006015	ABC transporter; Region: ABC_tran_2; pfam12848
342109006016	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
342109006017	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
342109006018	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
342109006019	ATP binding site [chemical binding]; other site
342109006020	Mg++ binding site [ion binding]; other site
342109006021	motif III; other site
342109006022	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109006023	nucleotide binding region [chemical binding]; other site
342109006024	ATP-binding site [chemical binding]; other site
342109006025	DbpA RNA binding domain; Region: DbpA; pfam03880
342109006026	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
342109006027	Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428
342109006028	Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696
342109006029	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
342109006030	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109006031	substrate binding pocket [chemical binding]; other site
342109006032	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
342109006033	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046
342109006034	putative C-terminal domain interface [polypeptide binding]; other site
342109006035	putative GSH binding site (G-site) [chemical binding]; other site
342109006036	putative dimer interface [polypeptide binding]; other site
342109006037	GST_C family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_C_GTT1_like; cd03189
342109006038	putative N-terminal domain interface [polypeptide binding]; other site
342109006039	putative dimer interface [polypeptide binding]; other site
342109006040	putative substrate binding pocket (H-site) [chemical binding]; other site
342109006041	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
342109006042	DNA-binding site [nucleotide binding]; DNA binding site
342109006043	RNA-binding motif; other site
342109006044	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
342109006045	YaeQ protein; Region: YaeQ; cl01913
342109006046	Predicted flavoproteins [General function prediction only]; Region: COG2081
342109006047	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109006048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
342109006049	active site
342109006050	phosphorylation site [posttranslational modification]
342109006051	intermolecular recognition site; other site
342109006052	dimerization interface [polypeptide binding]; other site
342109006053	PAS domain S-box; Region: sensory_box; TIGR00229
342109006054	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109006055	metal binding site [ion binding]; metal-binding site
342109006056	active site
342109006057	I-site; other site
342109006058	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
342109006059	Peptidase family M48; Region: Peptidase_M48; cl12018
342109006060	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
342109006061	active site
342109006062	HIGH motif; other site
342109006063	nucleotide binding site [chemical binding]; other site
342109006064	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
342109006065	active site
342109006066	KMSKS motif; other site
342109006067	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
342109006068	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
342109006069	NAD(P) binding site [chemical binding]; other site
342109006070	homotetramer interface [polypeptide binding]; other site
342109006071	homodimer interface [polypeptide binding]; other site
342109006072	active site
342109006073	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
342109006074	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
342109006075	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
342109006076	TraB family; Region: TraB; cl12050
342109006077	Protein of unknown function (DUF1684); Region: DUF1684; cl01327
342109006078	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
342109006079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109006080	ATP binding site [chemical binding]; other site
342109006081	Mg2+ binding site [ion binding]; other site
342109006082	G-X-G motif; other site
342109006083	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
342109006084	ATP binding site [chemical binding]; other site
342109006085	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
342109006086	Localisation of periplasmic protein complexes; Region: AMIN; pfam11741
342109006087	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
342109006088	active site
342109006089	metal binding site [ion binding]; metal-binding site
342109006090	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
342109006091	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
342109006092	putative carbohydrate kinase; Provisional; Region: PRK10565
342109006093	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
342109006094	putative substrate binding site [chemical binding]; other site
342109006095	putative ATP binding site [chemical binding]; other site
342109006096	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
342109006097	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
342109006098	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
342109006099	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489
342109006100	generic binding surface II; other site
342109006101	generic binding surface I; other site
342109006102	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
342109006103	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109006104	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109006105	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
342109006106	ribonuclease D; Region: rnd; TIGR01388
342109006107	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
342109006108	putative active site [active]
342109006109	catalytic site [active]
342109006110	putative substrate binding site [chemical binding]; other site
342109006111	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
342109006112	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
342109006113	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
342109006114	Predicted transcriptional regulator [Transcription]; Region: COG3905
342109006115	Transposase, Mutator family; Region: Transposase_mut; pfam00872
342109006116	MULE transposase domain; Region: MULE; pfam10551
342109006117	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109006118	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109006119	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
342109006120	active site
342109006121	DNA binding site [nucleotide binding]
342109006122	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
342109006123	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
342109006124	DEAD/H associated; Region: DEAD_assoc; pfam08494
342109006125	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
342109006126	Stringent starvation protein B; Region: SspB; cl01120
342109006127	stringent starvation protein A; Provisional; Region: sspA; PRK09481
342109006128	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
342109006129	C-terminal domain interface [polypeptide binding]; other site
342109006130	putative GSH binding site (G-site) [chemical binding]; other site
342109006131	dimer interface [polypeptide binding]; other site
342109006132	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_C_SspA; cd03186
342109006133	N-terminal domain interface [polypeptide binding]; other site
342109006134	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
342109006135	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284
342109006136	Qi binding site; other site
342109006137	intrachain domain interface; other site
342109006138	interchain domain interface [polypeptide binding]; other site
342109006139	cytochrome b; Provisional; Region: CYTB; MTH00156
342109006140	heme bH binding site [chemical binding]; other site
342109006141	heme bL binding site [chemical binding]; other site
342109006142	Qo binding site; other site
342109006143	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cl00193
342109006144	interchain domain interface [polypeptide binding]; other site
342109006145	intrachain domain interface; other site
342109006146	Qi binding site; other site
342109006147	Qo binding site; other site
342109006148	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
342109006149	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
342109006150	[2Fe-2S] cluster binding site [ion binding]; other site
342109006151	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
342109006152	N-acetyl-D-glucosamine binding site [chemical binding]; other site
342109006153	catalytic residue [active]
342109006154	Predicted transcriptional regulator [Transcription]; Region: COG2378
342109006155	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
342109006156	Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776
342109006157	dimer interface [polypeptide binding]; other site
342109006158	substrate binding pocket (H-site) [chemical binding]; other site
342109006159	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
342109006160	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
342109006161	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
342109006162	TRAM domain; Region: TRAM; cl01282
342109006163	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
342109006164	PhoH-like protein; Region: PhoH; cl12134
342109006165	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
342109006166	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
342109006167	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
342109006168	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
342109006169	Transporter associated domain; Region: CorC_HlyC; pfam03471
342109006170	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
342109006171	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
342109006172	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
342109006173	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
342109006174	NAD(P) binding site [chemical binding]; other site
342109006175	catalytic residues [active]
342109006176	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
342109006177	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
342109006178	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
342109006179	ABC-ATPase subunit interface; other site
342109006180	putative PBP binding loops; other site
342109006181	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
342109006182	ABC-ATPase subunit interface; other site
342109006183	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
342109006184	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109006185	Walker A/P-loop; other site
342109006186	ATP binding site [chemical binding]; other site
342109006187	Q-loop/lid; other site
342109006188	ABC transporter signature motif; other site
342109006189	Walker B; other site
342109006190	D-loop; other site
342109006191	H-loop/switch region; other site
342109006192	TOBE domain; Region: TOBE_2; cl01440
342109006193	NodT family; Region: outer_NodT; TIGR01845
342109006194	Outer membrane efflux protein; Region: OEP; pfam02321
342109006195	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
342109006196	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109006197	putative substrate translocation pore; other site
342109006198	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
342109006199	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109006200	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
342109006201	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
342109006202	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
342109006203	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
342109006204	conserved cys residue [active]
342109006205	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
342109006206	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
342109006207	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
342109006208	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
342109006209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109006210	Response regulator receiver domain; Region: Response_reg; pfam00072
342109006211	active site
342109006212	phosphorylation site [posttranslational modification]
342109006213	intermolecular recognition site; other site
342109006214	dimerization interface [polypeptide binding]; other site
342109006215	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109006216	metal binding site [ion binding]; metal-binding site
342109006217	active site
342109006218	I-site; other site
342109006219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109006220	metabolite-proton symporter; Region: 2A0106; TIGR00883
342109006221	putative substrate translocation pore; other site
342109006222	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
342109006223	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
342109006224	putative molybdopterin cofactor binding site [chemical binding]; other site
342109006225	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787
342109006226	putative molybdopterin cofactor binding site; other site
342109006227	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
342109006228	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
342109006229	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109006230	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109006231	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
342109006232	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
342109006233	inhibitor-cofactor binding pocket; inhibition site
342109006234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109006235	catalytic residue [active]
342109006236	ABC transporter G-25; Provisional; Region: PLN03211
342109006237	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
342109006238	recombination factor protein RarA; Reviewed; Region: PRK13342
342109006239	G1 box; other site
342109006240	GTP/Mg2+ binding site [chemical binding]; other site
342109006241	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
342109006242	Predicted membrane protein [Function unknown]; Region: COG2733
342109006243	CHASE domain; Region: CHASE; cl01369
342109006244	PAS domain S-box; Region: sensory_box; TIGR00229
342109006245	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342109006246	putative active site [active]
342109006247	heme pocket [chemical binding]; other site
342109006248	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
342109006249	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342109006250	putative active site [active]
342109006251	heme pocket [chemical binding]; other site
342109006252	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109006253	dimer interface [polypeptide binding]; other site
342109006254	phosphorylation site [posttranslational modification]
342109006255	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109006256	ATP binding site [chemical binding]; other site
342109006257	Mg2+ binding site [ion binding]; other site
342109006258	G-X-G motif; other site
342109006259	Response regulator receiver domain; Region: Response_reg; pfam00072
342109006260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109006261	active site
342109006262	phosphorylation site [posttranslational modification]
342109006263	intermolecular recognition site; other site
342109006264	dimerization interface [polypeptide binding]; other site
342109006265	Response regulator receiver domain; Region: Response_reg; pfam00072
342109006266	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109006267	active site
342109006268	phosphorylation site [posttranslational modification]
342109006269	intermolecular recognition site; other site
342109006270	dimerization interface [polypeptide binding]; other site
342109006271	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
342109006272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109006273	active site
342109006274	phosphorylation site [posttranslational modification]
342109006275	intermolecular recognition site; other site
342109006276	dimerization interface [polypeptide binding]; other site
342109006277	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
342109006278	Zn2+ binding site [ion binding]; other site
342109006279	Mg2+ binding site [ion binding]; other site
342109006280	Transposase domain (DUF772); Region: DUF772; cl12084
342109006281	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109006282	Glutamate dehydrogenase N terminal; Region: GDH_N; pfam12466
342109006283	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
342109006284	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
342109006285	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342109006286	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342109006287	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
342109006288	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
342109006289	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
342109006290	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109006291	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109006292	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342109006293	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342109006294	DNA binding site [nucleotide binding]
342109006295	domain linker motif; other site
342109006296	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280
342109006297	putative dimerization interface [polypeptide binding]; other site
342109006298	putative ligand binding site [chemical binding]; other site
342109006299	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
342109006300	active site
342109006301	phosphorylation site [posttranslational modification]
342109006302	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
342109006303	dimerization domain swap beta strand [polypeptide binding]; other site
342109006304	regulatory protein interface [polypeptide binding]; other site
342109006305	active site
342109006306	regulatory phosphorylation site [posttranslational modification]; other site
342109006307	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
342109006308	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
342109006309	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
342109006310	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
342109006311	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
342109006312	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
342109006313	putative substrate binding site [chemical binding]; other site
342109006314	putative ATP binding site [chemical binding]; other site
342109006315	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569
342109006316	P-loop; other site
342109006317	active site
342109006318	phosphorylation site [posttranslational modification]
342109006319	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
342109006320	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
342109006321	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
342109006322	Transposase domain (DUF772); Region: DUF772; cl12084
342109006323	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109006324	Transposase domain (DUF772); Region: DUF772; cl12084
342109006325	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109006326	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109006327	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109006328	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109006329	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109006330	putative transposase OrfB; Reviewed; Region: PHA02517
342109006331	Integrase core domain; Region: rve; cl01316
342109006332	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006333	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006334	Transposase domain (DUF772); Region: DUF772; cl12084
342109006335	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109006336	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109006337	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109006338	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
342109006339	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109006340	HSP20-like domain of unknown function (DUF1813); Region: DUF1813; cl07446
342109006341	Transposase domain (DUF772); Region: DUF772; cl12084
342109006342	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109006343	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109006344	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109006345	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109006346	Protein of unknown function (DUF461); Region: DUF461; cl01071
342109006347	TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779
342109006348	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
342109006349	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109006350	ligand-binding site [chemical binding]; other site
342109006351	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
342109006352	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
342109006353	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
342109006354	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
342109006355	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109006356	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
342109006357	flagellar motor protein MotA; Validated; Region: PRK08124
342109006358	flagellar motor protein MotD; Reviewed; Region: PRK09038
342109006359	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
342109006360	ligand binding site [chemical binding]; other site
342109006361	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
342109006362	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
342109006363	P-loop; other site
342109006364	Magnesium ion binding site [ion binding]; other site
342109006365	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
342109006366	Magnesium ion binding site [ion binding]; other site
342109006367	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
342109006368	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
342109006369	anti sigma factor interaction site; other site
342109006370	regulatory phosphorylation site [posttranslational modification]; other site
342109006371	Response regulator receiver domain; Region: Response_reg; pfam00072
342109006372	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109006373	active site
342109006374	phosphorylation site [posttranslational modification]
342109006375	intermolecular recognition site; other site
342109006376	dimerization interface [polypeptide binding]; other site
342109006377	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
342109006378	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
342109006379	putative binding surface; other site
342109006380	active site
342109006381	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
342109006382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109006383	ATP binding site [chemical binding]; other site
342109006384	Mg2+ binding site [ion binding]; other site
342109006385	G-X-G motif; other site
342109006386	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
342109006387	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109006388	Integrase core domain; Region: rve; cl01316
342109006389	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
342109006390	PAS fold; Region: PAS; pfam00989
342109006391	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
342109006392	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
342109006393	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109006394	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109006395	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
342109006396	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
342109006397	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
342109006398	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
342109006399	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
342109006400	CHASE3 domain; Region: CHASE3; cl05000
342109006401	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
342109006402	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
342109006403	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
342109006404	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
342109006405	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
342109006406	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
342109006407	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
342109006408	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
342109006409	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
342109006410	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
342109006411	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
342109006412	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
342109006413	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
342109006414	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
342109006415	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
342109006416	Flagellar regulator YcgR; Region: YcgR; pfam07317
342109006417	PilZ domain; Region: PilZ; cl01260
342109006418	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
342109006419	putative CheA interaction surface; other site
342109006420	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109006421	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109006422	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109006423	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109006424	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
342109006425	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
342109006426	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
342109006427	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
342109006428	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
342109006429	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
342109006430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109006431	CheD chemotactic sensory transduction; Region: CheD; cl00810
342109006432	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
342109006433	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109006434	active site
342109006435	phosphorylation site [posttranslational modification]
342109006436	intermolecular recognition site; other site
342109006437	dimerization interface [polypeptide binding]; other site
342109006438	CheB methylesterase; Region: CheB_methylest; pfam01339
342109006439	PAS domain S-box; Region: sensory_box; TIGR00229
342109006440	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342109006441	putative active site [active]
342109006442	heme pocket [chemical binding]; other site
342109006443	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
342109006444	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109006445	metal binding site [ion binding]; metal-binding site
342109006446	active site
342109006447	I-site; other site
342109006448	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
342109006449	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
342109006450	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109006451	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
342109006452	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change...; Region: AcnB_Swivel; cd01576
342109006453	substrate binding site [chemical binding]; other site
342109006454	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
342109006455	substrate binding site [chemical binding]; other site
342109006456	ligand binding site [chemical binding]; other site
342109006457	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
342109006458	putative active site [active]
342109006459	SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877
342109006460	aconitate hydratase; Validated; Region: PRK09277
342109006461	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
342109006462	substrate binding site [chemical binding]; other site
342109006463	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
342109006464	ligand binding site [chemical binding]; other site
342109006465	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
342109006466	substrate binding site [chemical binding]; other site
342109006467	putative long-chain fatty acyl CoA ligase; Provisional; Region: PRK08751
342109006468	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
342109006469	enoyl-CoA hydratase; Validated; Region: PRK08788
342109006470	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
342109006471	substrate binding site [chemical binding]; other site
342109006472	oxyanion hole (OAH) forming residues; other site
342109006473	trimer interface [polypeptide binding]; other site
342109006474	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109006475	dimer interface [polypeptide binding]; other site
342109006476	phosphorylation site [posttranslational modification]
342109006477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109006478	ATP binding site [chemical binding]; other site
342109006479	Mg2+ binding site [ion binding]; other site
342109006480	G-X-G motif; other site
342109006481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109006482	Response regulator receiver domain; Region: Response_reg; pfam00072
342109006483	active site
342109006484	phosphorylation site [posttranslational modification]
342109006485	intermolecular recognition site; other site
342109006486	dimerization interface [polypeptide binding]; other site
342109006487	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
342109006488	putative binding surface; other site
342109006489	active site
342109006490	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
342109006491	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109006492	active site
342109006493	phosphorylation site [posttranslational modification]
342109006494	intermolecular recognition site; other site
342109006495	dimerization interface [polypeptide binding]; other site
342109006496	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
342109006497	Zn2+ binding site [ion binding]; other site
342109006498	Mg2+ binding site [ion binding]; other site
342109006499	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
342109006500	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322
342109006501	dimer interface [polypeptide binding]; other site
342109006502	putative anticodon binding site; other site
342109006503	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
342109006504	motif 1; other site
342109006505	active site
342109006506	motif 2; other site
342109006507	motif 3; other site
342109006508	peptide chain release factor 2; Provisional; Region: PRK08787
342109006509	RF-1 domain; Region: RF-1; cl02875
342109006510	RF-1 domain; Region: RF-1; cl02875
342109006511	LytTr DNA-binding domain; Region: LytTR; cl04498
342109006512	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
342109006513	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109006514	Integrase core domain; Region: rve; cl01316
342109006515	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109006516	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109006517	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
342109006518	DHH family; Region: DHH; pfam01368
342109006519	DHHA1 domain; Region: DHHA1; pfam02272
342109006520	Sulfatase; Region: Sulfatase; cl10460
342109006521	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
342109006522	domain; Region: GreA_GreB_N; pfam03449
342109006523	C-term; Region: GreA_GreB; pfam01272
342109006524	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
342109006525	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
342109006526	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109006527	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
342109006528	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
342109006529	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109006530	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
342109006531	IMP binding site; other site
342109006532	dimer interface [polypeptide binding]; other site
342109006533	interdomain contacts; other site
342109006534	partial ornithine binding site; other site
342109006535	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
342109006536	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
342109006537	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
342109006538	catalytic site [active]
342109006539	subunit interface [polypeptide binding]; other site
342109006540	dihydrodipicolinate reductase; Provisional; Region: PRK00048
342109006541	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109006542	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
342109006543	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109006544	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109006545	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
342109006546	MOSC domain; Region: MOSC; pfam03473
342109006547	3-alpha domain; Region: 3-alpha; pfam03475
342109006548	aspartate aminotransferase; Provisional; Region: PRK06836
342109006549	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342109006550	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109006551	homodimer interface [polypeptide binding]; other site
342109006552	catalytic residue [active]
342109006553	Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions.  FeoB has been identified as part of this...; Region: FeoB; cd01879
342109006554	G1 box; other site
342109006555	GTP/Mg2+ binding site [chemical binding]; other site
342109006556	Switch I region; other site
342109006557	G2 box; other site
342109006558	G3 box; other site
342109006559	Switch II region; other site
342109006560	G4 box; other site
342109006561	G5 box; other site
342109006562	Nucleoside recognition; Region: Gate; cl00486
342109006563	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
342109006564	Nucleoside recognition; Region: Gate; cl00486
342109006565	FeoA domain; Region: FeoA; cl00838
342109006566	enoyl-CoA hydratase; Provisional; Region: PRK05995
342109006567	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
342109006568	substrate binding site [chemical binding]; other site
342109006569	oxyanion hole (OAH) forming residues; other site
342109006570	trimer interface [polypeptide binding]; other site
342109006571	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
342109006572	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
342109006573	active site
342109006574	catalytic residues [active]
342109006575	metal binding site [ion binding]; metal-binding site
342109006576	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109006577	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
342109006578	NAD(P) binding site [chemical binding]; other site
342109006579	active site
342109006580	elongation factor P; Provisional; Region: PRK04542
342109006581	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
342109006582	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
342109006583	RNA binding site [nucleotide binding]; other site
342109006584	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
342109006585	RNA binding site [nucleotide binding]; other site
342109006586	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109006587	Integrase core domain; Region: rve; cl01316
342109006588	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
342109006589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109006590	putative substrate translocation pore; other site
342109006591	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109006592	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
342109006593	xylose isomerase; Region: PLN02923
342109006594	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
342109006595	D-xylulose kinase; Region: XylB; TIGR01312
342109006596	FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782
342109006597	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
342109006598	PA14 domain; Region: PA14; cl08459
342109006599	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
342109006600	putative active site [active]
342109006601	putative catalytic site [active]
342109006602	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
342109006603	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109006604	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
342109006605	putative dimerization interface [polypeptide binding]; other site
342109006606	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
342109006607	active site
342109006608	intersubunit interface [polypeptide binding]; other site
342109006609	catalytic residue [active]
342109006610	galactonate dehydratase; Provisional; Region: PRK14017
342109006611	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
342109006612	putative active site pocket [active]
342109006613	putative metal binding site [ion binding]; other site
342109006614	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
342109006615	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
342109006616	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
342109006617	Ferredoxin [Energy production and conversion]; Region: COG1146
342109006618	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
342109006619	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
342109006620	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
342109006621	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
342109006622	dimer interface [polypeptide binding]; other site
342109006623	active site
342109006624	catalytic residue [active]
342109006625	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
342109006626	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
342109006627	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
342109006628	Protein of unknown function (DUF1260); Region: DUF1260; cl01170
342109006629	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017
342109006630	catalytic triad [active]
342109006631	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
342109006632	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
342109006633	putative active site [active]
342109006634	PhoH-like protein; Region: PhoH; cl12134
342109006635	bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427
342109006636	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
342109006637	dimer interface [polypeptide binding]; other site
342109006638	substrate binding site [chemical binding]; other site
342109006639	ATP binding site [chemical binding]; other site
342109006640	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
342109006641	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
342109006642	active site residue [active]
342109006643	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
342109006644	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109006645	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109006646	dimerization interface [polypeptide binding]; other site
342109006647	Pirin-related protein [General function prediction only]; Region: COG1741
342109006648	Cupin domain; Region: Cupin_2; cl09118
342109006649	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
342109006650	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
342109006651	catalytic residue [active]
342109006652	IPP transferase; Region: IPPT; cl00403
342109006653	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109006654	Walker A motif; other site
342109006655	ATP binding site [chemical binding]; other site
342109006656	Global regulator protein family; Region: CsrA; cl00670
342109006657	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
342109006658	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673
342109006659	motif 1; other site
342109006660	active site
342109006661	motif 2; other site
342109006662	motif 3; other site
342109006663	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
342109006664	DHHA1 domain; Region: DHHA1; pfam02272
342109006665	RecX family; Region: RecX; cl00936
342109006666	recombinase A; Provisional; Region: recA; PRK09354
342109006667	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
342109006668	hexamer interface [polypeptide binding]; other site
342109006669	Walker A motif; other site
342109006670	ATP binding site [chemical binding]; other site
342109006671	Walker B motif; other site
342109006672	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109006673	LexA repressor; Validated; Region: PRK00215
342109006674	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
342109006675	Catalytic site [active]
342109006676	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
342109006677	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
342109006678	Competence-damaged protein; Region: CinA; cl00666
342109006679	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
342109006680	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
342109006681	G1 box; other site
342109006682	GTP/Mg2+ binding site [chemical binding]; other site
342109006683	Switch I region; other site
342109006684	G2 box; other site
342109006685	G3 box; other site
342109006686	Switch II region; other site
342109006687	G4 box; other site
342109006688	G5 box; other site
342109006689	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
342109006690	Sm1 motif; other site
342109006691	intra - hexamer interaction site; other site
342109006692	inter - hexamer interaction site [polypeptide binding]; other site
342109006693	nucleotide binding pocket [chemical binding]; other site
342109006694	Sm2 motif; other site
342109006695	IPP transferase; Region: IPPT; cl00403
342109006696	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
342109006697	dihydropteroate synthase; Region: DHPS; TIGR01496
342109006698	substrate binding pocket [chemical binding]; other site
342109006699	dimer interface [polypeptide binding]; other site
342109006700	inhibitor binding site; inhibition site
342109006701	FtsH Extracellular; Region: FtsH_ext; pfam06480
342109006702	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
342109006703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109006704	Walker A motif; other site
342109006705	ATP binding site [chemical binding]; other site
342109006706	Walker B motif; other site
342109006707	arginine finger; other site
342109006708	Peptidase family M41; Region: Peptidase_M41; pfam01434
342109006709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109006710	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
342109006711	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome...; Region: Xcc1710_like; cd05560
342109006712	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
342109006713	putative peptidoglycan binding site; other site
342109006714	Peptidase family M23; Region: Peptidase_M23; pfam01551
342109006715	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
342109006716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109006717	Survival protein SurE; Region: SurE; cl00448
342109006718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
342109006719	Smr domain; Region: Smr; cl02619
342109006720	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
342109006721	PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575
342109006722	Permutation of conserved domain; other site
342109006723	active site
342109006724	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
342109006725	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554
342109006726	homotrimer interaction site [polypeptide binding]; other site
342109006727	zinc binding site [ion binding]; other site
342109006728	CDP-binding sites; other site
342109006729	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
342109006730	substrate binding site [chemical binding]; other site
342109006731	dimer interface [polypeptide binding]; other site
342109006732	Septum formation initiator; Region: DivIC; cl11433
342109006733	enolase; Provisional; Region: eno; PRK00077
342109006734	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
342109006735	dimer interface [polypeptide binding]; other site
342109006736	metal binding site [ion binding]; metal-binding site
342109006737	substrate binding pocket [chemical binding]; other site
342109006738	NeuB family; Region: NeuB; cl00496
342109006739	CTP synthetase; Validated; Region: pyrG; PRK05380
342109006740	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113
342109006741	Catalytic site [active]
342109006742	Active site [active]
342109006743	UTP binding site [chemical binding]; other site
342109006744	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
342109006745	active site
342109006746	putative oxyanion hole; other site
342109006747	catalytic triad [active]
342109006748	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
342109006749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
342109006750	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
342109006751	anchoring element; other site
342109006752	dimer interface [polypeptide binding]; other site
342109006753	ATP binding site [chemical binding]; other site
342109006754	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
342109006755	active site
342109006756	metal binding site [ion binding]; metal-binding site
342109006757	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
342109006758	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109006759	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109006760	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109006761	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
342109006762	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
342109006763	putative active site [active]
342109006764	Phosphate transporter family; Region: PHO4; cl00396
342109006765	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
342109006766	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
342109006767	Domain of unknown function DUF21; Region: DUF21; pfam01595
342109006768	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
342109006769	Transporter associated domain; Region: CorC_HlyC; pfam03471
342109006770	Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617
342109006771	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
342109006772	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
342109006773	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
342109006774	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
342109006775	benzoate transport; Region: 2A0115; TIGR00895
342109006776	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
342109006777	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
342109006778	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109006779	Walker A/P-loop; other site
342109006780	ATP binding site [chemical binding]; other site
342109006781	Q-loop/lid; other site
342109006782	ABC transporter signature motif; other site
342109006783	Walker B; other site
342109006784	D-loop; other site
342109006785	H-loop/switch region; other site
342109006786	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918
342109006787	Hpr binding site; other site
342109006788	active site
342109006789	homohexamer subunit interaction site [polypeptide binding]; other site
342109006790	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293
342109006791	B12 binding site [chemical binding]; other site
342109006792	Radical SAM; Region: Elp3; smart00729
342109006793	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
342109006794	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109006795	Integrase core domain; Region: rve; cl01316
342109006796	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
342109006797	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
342109006798	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
342109006799	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
342109006800	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109006801	S-adenosylmethionine binding site [chemical binding]; other site
342109006802	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
342109006803	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
342109006804	active site
342109006805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109006806	S-adenosylmethionine binding site [chemical binding]; other site
342109006807	Chain length determinant protein; Region: Wzz; cl01623
342109006808	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
342109006809	active site
342109006810	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
342109006811	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
342109006812	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
342109006813	inhibitor-cofactor binding pocket; inhibition site
342109006814	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109006815	catalytic residue [active]
342109006816	FemAB family; Region: FemAB; cl11444
342109006817	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
342109006818	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
342109006819	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
342109006820	putative trimer interface [polypeptide binding]; other site
342109006821	putative CoA binding site [chemical binding]; other site
342109006822	Cupin domain; Region: Cupin_2; cl09118
342109006823	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859
342109006824	Cytochrome c; Region: Cytochrom_C; cl11414
342109006825	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
342109006826	RNA polymerase sigma factor; Provisional; Region: PRK12515
342109006827	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342109006828	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
342109006829	DNA binding residues [nucleotide binding]
342109006830	Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492
342109006831	active site
342109006832	catalytic triad [active]
342109006833	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
342109006834	CcmE; Region: CcmE; cl00994
342109006835	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
342109006836	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
342109006837	catalytic residues [active]
342109006838	central insert; other site
342109006839	Cytochrome C biogenesis protein; Region: CcmH; cl01179
342109006840	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
342109006841	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006842	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006843	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006844	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006845	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006846	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006847	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006848	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006849	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006850	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006851	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006852	Phage protein; Region: DUF3653; pfam12375
342109006853	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006854	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006855	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006856	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109006857	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
342109006858	Transposase domain (DUF772); Region: DUF772; cl12084
342109006859	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
342109006860	Protein export membrane protein; Region: SecD_SecF; cl14618
342109006861	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
342109006862	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
342109006863	Transposase domain (DUF772); Region: DUF772; cl12084
342109006864	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109006865	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109006866	Transposase, Mutator family; Region: Transposase_mut; pfam00872
342109006867	MULE transposase domain; Region: MULE; pfam10551
342109006868	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
342109006869	two-component response regulator VirG; Provisional; Region: PRK13856
342109006870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109006871	active site
342109006872	phosphorylation site [posttranslational modification]
342109006873	intermolecular recognition site; other site
342109006874	dimerization interface [polypeptide binding]; other site
342109006875	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109006876	DNA binding site [nucleotide binding]
342109006877	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
342109006878	two-component VirA-like sensor kinase; Provisional; Region: PRK13837
342109006879	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109006880	dimer interface [polypeptide binding]; other site
342109006881	phosphorylation site [posttranslational modification]
342109006882	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109006883	ATP binding site [chemical binding]; other site
342109006884	Mg2+ binding site [ion binding]; other site
342109006885	G-X-G motif; other site
342109006886	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109006887	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342109006888	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
342109006889	dimerization interface [polypeptide binding]; other site
342109006890	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
342109006891	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
342109006892	Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219
342109006893	Catalytic domain of Protein Kinases; Region: PKc; cd00180
342109006894	active site
342109006895	ATP binding site [chemical binding]; other site
342109006896	substrate binding site [chemical binding]; other site
342109006897	activation loop (A-loop); other site
342109006898	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
342109006899	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
342109006900	Protein phosphatase 2C; Region: PP2C; pfam00481
342109006901	Active site [active]
342109006902	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
342109006903	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
342109006904	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
342109006905	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
342109006906	hypothetical protein; Provisional; Region: PRK07033
342109006907	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
342109006908	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
342109006909	ligand binding site [chemical binding]; other site
342109006910	Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406
342109006911	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
342109006912	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
342109006913	phosphopeptide binding site; other site
342109006914	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109006915	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109006916	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
342109006917	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109006918	Walker A motif; other site
342109006919	ATP binding site [chemical binding]; other site
342109006920	Walker B motif; other site
342109006921	arginine finger; other site
342109006922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109006923	Walker A motif; other site
342109006924	ATP binding site [chemical binding]; other site
342109006925	Walker B motif; other site
342109006926	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
342109006927	Protein of unknown function (DUF1305); Region: DUF1305; cl01404
342109006928	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
342109006929	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
342109006930	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
342109006931	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
342109006932	ImpE protein; Region: ImpE; pfam07024
342109006933	Protein of unknown function (DUF796); Region: DUF796; cl01226
342109006934	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
342109006935	Protein of unknown function (DUF877); Region: DUF877; pfam05943
342109006936	Protein of unknown function (DUF770); Region: DUF770; cl01402
342109006937	Transposase domain (DUF772); Region: DUF772; cl12084
342109006938	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109006939	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109006940	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109006941	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109006942	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109006943	Transposase domain (DUF772); Region: DUF772; cl12084
342109006944	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109006945	Integrase core domain; Region: rve; cl01316
342109006946	putative transposase OrfB; Reviewed; Region: PHA02517
342109006947	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
342109006948	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
342109006949	NifU-like domain; Region: NifU; cl00484
342109006950	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
342109006951	aromatic arch; other site
342109006952	DCoH dimer interaction site [polypeptide binding]; other site
342109006953	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
342109006954	DCoH tetramer interaction site [polypeptide binding]; other site
342109006955	substrate binding site [chemical binding]; other site
342109006956	Gram-negative bacterial tonB protein; Region: TonB; cl10048
342109006957	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
342109006958	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
342109006959	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
342109006960	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
342109006961	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
342109006962	RNA binding surface [nucleotide binding]; other site
342109006963	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
342109006964	active site
342109006965	ribonuclease E; Reviewed; Region: rne; PRK10811
342109006966	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
342109006967	homodimer interface [polypeptide binding]; other site
342109006968	oligonucleotide binding site [chemical binding]; other site
342109006969	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109006970	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109006971	response regulator; Provisional; Region: PRK09483
342109006972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109006973	active site
342109006974	phosphorylation site [posttranslational modification]
342109006975	intermolecular recognition site; other site
342109006976	dimerization interface [polypeptide binding]; other site
342109006977	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
342109006978	DNA binding residues [nucleotide binding]
342109006979	dimerization interface [polypeptide binding]; other site
342109006980	rhodanese superfamily protein; Provisional; Region: PRK05320
342109006981	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
342109006982	active site residue [active]
342109006983	Transposase domain (DUF772); Region: DUF772; cl12084
342109006984	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109006985	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
342109006986	flavoprotein, HI0933 family; Region: TIGR00275
342109006987	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109006988	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
342109006989	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
342109006990	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
342109006991	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
342109006992	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
342109006993	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109006994	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109006995	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109006996	Transposase domain (DUF772); Region: DUF772; cl12084
342109006997	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109006998	Transposase domain (DUF772); Region: DUF772; cl12084
342109006999	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109007000	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109007001	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109007002	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109007003	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109007004	ANTAR domain; Region: ANTAR; pfam03861
342109007005	precorrin-2 dehydrogenase; Validated; Region: PRK06719
342109007006	siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470
342109007007	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
342109007008	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109007009	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
342109007010	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
342109007011	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
342109007012	GTP binding site [chemical binding]; other site
342109007013	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
342109007014	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
342109007015	dimer interface [polypeptide binding]; other site
342109007016	putative functional site; other site
342109007017	putative MPT binding site; other site
342109007018	PQ loop repeat; Region: PQ-loop; cl12056
342109007019	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109007020	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109007021	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109007022	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109007023	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109007024	Integrase core domain; Region: rve; cl01316
342109007025	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109007026	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007027	FtsI repressor; Provisional; Region: PRK10883
342109007028	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815
342109007029	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109007030	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109007031	Transposase, Mutator family; Region: Transposase_mut; pfam00872
342109007032	MULE transposase domain; Region: MULE; pfam10551
342109007033	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
342109007034	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
342109007035	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109007036	Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616
342109007037	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
342109007038	substrate binding site [chemical binding]; other site
342109007039	active site
342109007040	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
342109007041	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
342109007042	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
342109007043	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109007044	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109007045	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
342109007046	Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; pfam09286
342109007047	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
342109007048	active site
342109007049	catalytic triad [active]
342109007050	calcium binding site [ion binding]; other site
342109007051	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
342109007052	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109007053	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
342109007054	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
342109007055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
342109007056	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
342109007057	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
342109007058	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
342109007059	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279
342109007060	active site
342109007061	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
342109007062	dimer interface [polypeptide binding]; other site
342109007063	NADP binding site [chemical binding]; other site
342109007064	catalytic residues [active]
342109007065	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
342109007066	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
342109007067	inhibitor site; inhibition site
342109007068	active site
342109007069	dimer interface [polypeptide binding]; other site
342109007070	catalytic residue [active]
342109007071	mercuric reductase; Validated; Region: PRK06370
342109007072	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
342109007073	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
342109007074	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
342109007075	Proline racemase; Region: Pro_racemase; pfam05544
342109007076	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
342109007077	PAS fold; Region: PAS_4; pfam08448
342109007078	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
342109007079	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
342109007080	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
342109007081	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
342109007082	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
342109007083	GTP binding site [chemical binding]; other site
342109007084	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
342109007085	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
342109007086	minor groove reading motif; other site
342109007087	helix-hairpin-helix signature motif; other site
342109007088	substrate binding pocket [chemical binding]; other site
342109007089	active site
342109007090	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
342109007091	DNA binding and oxoG recognition site [nucleotide binding]
342109007092	Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104
342109007093	histidine kinase; Provisional; Region: PRK13557
342109007094	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342109007095	putative active site [active]
342109007096	heme pocket [chemical binding]; other site
342109007097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109007098	ATP binding site [chemical binding]; other site
342109007099	G-X-G motif; other site
342109007100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109007101	active site
342109007102	phosphorylation site [posttranslational modification]
342109007103	intermolecular recognition site; other site
342109007104	dimerization interface [polypeptide binding]; other site
342109007105	Transposase domain (DUF772); Region: DUF772; cl12084
342109007106	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109007107	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109007108	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109007109	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
342109007110	Predicted transcriptional regulator [Transcription]; Region: COG5340
342109007111	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109007112	Integrase core domain; Region: rve; cl01316
342109007113	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
342109007114	PE-PPE domain; Region: PE-PPE; pfam08237
342109007115	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
342109007116	catalytic residues [active]
342109007117	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109007118	Integrase core domain; Region: rve; cl01316
342109007119	TraB family; Region: TraB; cl12050
342109007120	Cupin superfamily (DUF985); Region: Cupin_5; cl01418
342109007121	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
342109007122	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
342109007123	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
342109007124	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
342109007125	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
342109007126	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
342109007127	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
342109007128	Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792
342109007129	Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792
342109007130	Acyltransferase family; Region: Acyl_transf_3; pfam01757
342109007131	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
342109007132	Bacterial sugar transferase; Region: Bac_transf; cl00939
342109007133	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
342109007134	Chain length determinant protein; Region: Wzz; cl01623
342109007135	Chain length determinant protein; Region: Wzz; cl01623
342109007136	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
342109007137	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
342109007138	SLBB domain; Region: SLBB; pfam10531
342109007139	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
342109007140	DNA binding residues [nucleotide binding]
342109007141	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
342109007142	IHF dimer interface [polypeptide binding]; other site
342109007143	IHF - DNA interface [nucleotide binding]; other site
342109007144	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
342109007145	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
342109007146	putative tRNA-binding site [nucleotide binding]; other site
342109007147	B3/4 domain; Region: B3_4; cl11458
342109007148	tRNA synthetase B5 domain; Region: B5; cl08394
342109007149	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
342109007150	dimer interface [polypeptide binding]; other site
342109007151	motif 1; other site
342109007152	motif 3; other site
342109007153	motif 2; other site
342109007154	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
342109007155	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
342109007156	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
342109007157	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
342109007158	dimer interface [polypeptide binding]; other site
342109007159	motif 1; other site
342109007160	active site
342109007161	motif 2; other site
342109007162	motif 3; other site
342109007163	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
342109007164	23S rRNA binding site [nucleotide binding]; other site
342109007165	L21 binding site [polypeptide binding]; other site
342109007166	L13 binding site [polypeptide binding]; other site
342109007167	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
342109007168	translation initiation factor IF-3; Region: infC; TIGR00168
342109007169	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
342109007170	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
342109007171	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
342109007172	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667
342109007173	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
342109007174	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
342109007175	active site
342109007176	dimer interface [polypeptide binding]; other site
342109007177	motif 1; other site
342109007178	motif 2; other site
342109007179	motif 3; other site
342109007180	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
342109007181	anticodon binding site; other site
342109007182	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109007183	excinuclease ABC subunit B; Provisional; Region: PRK05298
342109007184	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342109007185	ATP binding site [chemical binding]; other site
342109007186	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109007187	nucleotide binding region [chemical binding]; other site
342109007188	ATP-binding site [chemical binding]; other site
342109007189	Ultra-violet resistance protein B; Region: UvrB; pfam12344
342109007190	UvrB/uvrC motif; Region: UVR; pfam02151
342109007191	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
342109007192	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
342109007193	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
342109007194	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
342109007195	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
342109007196	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
342109007197	Type II transport protein GspH; Region: GspH; pfam12019
342109007198	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
342109007199	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
342109007200	The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393
342109007201	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109007202	MarC family integral membrane protein; Region: MarC; cl00919
342109007203	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109007204	NAD(P) binding site [chemical binding]; other site
342109007205	active site
342109007206	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
342109007207	putative GSH binding site [chemical binding]; other site
342109007208	catalytic residues [active]
342109007209	superoxide dismutase; Provisional; Region: PRK10543
342109007210	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
342109007211	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
342109007212	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
342109007213	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109007214	AIR carboxylase; Region: AIRC; cl00310
342109007215	Trm112p-like protein; Region: Trm112p; cl01066
342109007216	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
342109007217	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572
342109007218	dimerization interface [polypeptide binding]; other site
342109007219	active site
342109007220	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776
342109007221	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
342109007222	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
342109007223	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
342109007224	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
342109007225	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
342109007226	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
342109007227	putative nucleic acid binding region [nucleotide binding]; other site
342109007228	G-X-X-G motif; other site
342109007229	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472
342109007230	RNA binding site [nucleotide binding]; other site
342109007231	domain interface; other site
342109007232	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353
342109007233	16S/18S rRNA binding site [nucleotide binding]; other site
342109007234	S13e-L30e interaction site [polypeptide binding]; other site
342109007235	25S rRNA binding site [nucleotide binding]; other site
342109007236	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04642
342109007237	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573
342109007238	RNA binding site [nucleotide binding]; other site
342109007239	active site
342109007240	Ribosome-binding factor A; Region: RBFA; cl00542
342109007241	translation initiation factor IF-2; Validated; Region: infB; PRK05306
342109007242	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
342109007243	translation initiation factor IF-2; Region: IF-2; TIGR00487
342109007244	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
342109007245	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases...; Region: IF2_eIF5B; cd01887
342109007246	G1 box; other site
342109007247	putative GEF interaction site [polypeptide binding]; other site
342109007248	GTP/Mg2+ binding site [chemical binding]; other site
342109007249	Switch I region; other site
342109007250	G2 box; other site
342109007251	G3 box; other site
342109007252	Switch II region; other site
342109007253	G4 box; other site
342109007254	G5 box; other site
342109007255	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702
342109007256	Translation-initiation factor 2; Region: IF-2; pfam11987
342109007257	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692
342109007258	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
342109007259	NusA N-terminal domain; Region: NusA_N; pfam08529
342109007260	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455
342109007261	RNA binding site [nucleotide binding]; other site
342109007262	homodimer interface [polypeptide binding]; other site
342109007263	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
342109007264	G-X-X-G motif; other site
342109007265	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
342109007266	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
342109007267	ribosome maturation protein RimP; Reviewed; Region: PRK00092
342109007268	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
342109007269	Sm1 motif; other site
342109007270	D3 - B interaction site; other site
342109007271	D1 - D2 interaction site; other site
342109007272	Hfq - Hfq interaction site; other site
342109007273	RNA binding pocket [nucleotide binding]; other site
342109007274	Sm2 motif; other site
342109007275	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
342109007276	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
342109007277	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
342109007278	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
342109007279	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
342109007280	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
342109007281	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
342109007282	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
342109007283	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
342109007284	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
342109007285	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
342109007286	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
342109007287	NADH dehydrogenase; Region: NADHdh; cl00469
342109007288	NADH dehydrogenase subunit G; Validated; Region: PRK09129
342109007289	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
342109007290	catalytic loop [active]
342109007291	iron binding site [ion binding]; other site
342109007292	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
342109007293	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
342109007294	molybdopterin cofactor binding site; other site
342109007295	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cd02775
342109007296	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
342109007297	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
342109007298	SLBB domain; Region: SLBB; pfam10531
342109007299	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
342109007300	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
342109007301	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064
342109007302	putative dimer interface [polypeptide binding]; other site
342109007303	[2Fe-2S] cluster binding site [ion binding]; other site
342109007304	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417
342109007305	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539
342109007306	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419
342109007307	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
342109007308	Preprotein translocase SecG subunit; Region: SecG; cl09123
342109007309	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
342109007310	substrate binding site [chemical binding]; other site
342109007311	dimer interface [polypeptide binding]; other site
342109007312	catalytic triad [active]
342109007313	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
342109007314	classical (c) SDRs; Region: SDR_c; cd05233
342109007315	NAD(P) binding site [chemical binding]; other site
342109007316	active site
342109007317	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454
342109007318	apolar tunnel; other site
342109007319	heme binding site [chemical binding]; other site
342109007320	dimerization interface [polypeptide binding]; other site
342109007321	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007322	Integrase core domain; Region: rve; cl01316
342109007323	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
342109007324	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109007325	metal binding site [ion binding]; metal-binding site
342109007326	active site
342109007327	I-site; other site
342109007328	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
342109007329	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
342109007330	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
342109007331	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
342109007332	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802
342109007333	active site
342109007334	substrate binding site [chemical binding]; other site
342109007335	metal binding site [ion binding]; metal-binding site
342109007336	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
342109007337	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
342109007338	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724
342109007339	substrate binding site [chemical binding]; other site
342109007340	active site
342109007341	catalytic residues [active]
342109007342	heterodimer interface [polypeptide binding]; other site
342109007343	tryptophan synthase, beta chain; Region: PLN02618
342109007344	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
342109007345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109007346	catalytic residue [active]
342109007347	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109007348	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
342109007349	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109007350	dimerization interface [polypeptide binding]; other site
342109007351	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405
342109007352	active site
342109007353	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
342109007354	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570
342109007355	dimerization interface 3.5A [polypeptide binding]; other site
342109007356	active site
342109007357	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
342109007358	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
342109007359	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
342109007360	FimV N-terminal domain; Region: FimV_core; TIGR03505
342109007361	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
342109007362	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
342109007363	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
342109007364	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109007365	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
342109007366	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
342109007367	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109007368	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
342109007369	Tetramer interface [polypeptide binding]; other site
342109007370	Active site [active]
342109007371	FMN-binding site [chemical binding]; other site
342109007372	HemK family putative methylases; Region: hemK_fam; TIGR00536
342109007373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109007374	S-adenosylmethionine binding site [chemical binding]; other site
342109007375	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
342109007376	Cu(I) binding site [ion binding]; other site
342109007377	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
342109007378	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
342109007379	N-acetyl-D-glucosamine binding site [chemical binding]; other site
342109007380	catalytic residue [active]
342109007381	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
342109007382	putative peptidoglycan binding site; other site
342109007383	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
342109007384	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109007385	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
342109007386	domain; Region: GreA_GreB_N; pfam03449
342109007387	C-term; Region: GreA_GreB; pfam01272
342109007388	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
342109007389	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
342109007390	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
342109007391	FeS/SAM binding site; other site
342109007392	Dienelactone hydrolase family; Region: DLH; pfam01738
342109007393	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228
342109007394	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
342109007395	trimer interface [polypeptide binding]; other site
342109007396	active site
342109007397	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
342109007398	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
342109007399	Walker A motif; other site
342109007400	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109007401	Integrase core domain; Region: rve; cl01316
342109007402	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
342109007403	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
342109007404	active site
342109007405	Zn binding site [ion binding]; other site
342109007406	Rhomboid family; Region: Rhomboid; cl11446
342109007407	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
342109007408	DNA binding site [nucleotide binding]
342109007409	active site
342109007410	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109007411	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109007412	glutathione reductase; Validated; Region: PRK06116
342109007413	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
342109007414	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
342109007415	Predicted membrane protein [Function unknown]; Region: COG2311
342109007416	Protein of unknown function (DUF418); Region: DUF418; cl12135
342109007417	Protein of unknown function (DUF418); Region: DUF418; cl12135
342109007418	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
342109007419	NlpC/P60 family; Region: NLPC_P60; cl11438
342109007420	NlpC/P60 family; Region: NLPC_P60; cl11438
342109007421	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442
342109007422	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109007423	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
342109007424	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016
342109007425	Alkaline phosphatase homologues; Region: alkPPc; smart00098
342109007426	active site
342109007427	dimer interface [polypeptide binding]; other site
342109007428	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
342109007429	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
342109007430	Ligand Binding Site [chemical binding]; other site
342109007431	TilS substrate binding domain; Region: TilS; pfam09179
342109007432	B3/4 domain; Region: B3_4; cl11458
342109007433	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
342109007434	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
342109007435	substrate binding pocket [chemical binding]; other site
342109007436	chain length determination region; other site
342109007437	substrate-Mg2+ binding site; other site
342109007438	catalytic residues [active]
342109007439	aspartate-rich region 1; other site
342109007440	active site lid residues [active]
342109007441	aspartate-rich region 2; other site
342109007442	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
342109007443	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
342109007444	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
342109007445	Protein of unknown function (DUF615); Region: DUF615; cl01147
342109007446	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
342109007447	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
342109007448	TIGR02099 family protein; Region: TIGR02099
342109007449	ribonuclease G; Provisional; Region: PRK11712
342109007450	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
342109007451	homodimer interface [polypeptide binding]; other site
342109007452	oligonucleotide binding site [chemical binding]; other site
342109007453	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
342109007454	active site
342109007455	dimer interface [polypeptide binding]; other site
342109007456	Protein of unknown function (DUF541); Region: SIMPL; cl01077
342109007457	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109007458	Gram-negative bacterial tonB protein; Region: TonB; cl10048
342109007459	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679
342109007460	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
342109007461	Domain of unknown function DUF143; Region: DUF143; cl00519
342109007462	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
342109007463	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
342109007464	active site
342109007465	(T/H)XGH motif; other site
342109007466	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
342109007467	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
342109007468	Lipopolysaccharide-assembly; Region: LptE; cl01125
342109007469	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
342109007470	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
342109007471	HIGH motif; other site
342109007472	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
342109007473	active site
342109007474	KMSKS motif; other site
342109007475	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
342109007476	tRNA binding surface [nucleotide binding]; other site
342109007477	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
342109007478	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
342109007479	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
342109007480	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109007481	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109007482	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109007483	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109007484	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007485	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007486	Domain of unknown function (DUF378); Region: DUF378; cl00943
342109007487	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
342109007488	active site
342109007489	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109007490	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109007491	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109007492	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109007493	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109007494	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007495	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007496	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
342109007497	Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856
342109007498	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
342109007499	Transposase domain (DUF772); Region: DUF772; cl12084
342109007500	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109007501	Transposase domain (DUF772); Region: DUF772; cl12084
342109007502	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109007503	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109007504	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007505	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007506	Integrase core domain; Region: rve; cl01316
342109007507	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109007508	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007509	H-NS histone family; Region: Histone_HNS; pfam00816
342109007510	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
342109007511	Integrase core domain; Region: rve; cl01316
342109007512	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109007513	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
342109007514	DNA binding site [nucleotide binding]
342109007515	Int/Topo IB signature motif; other site
342109007516	active site
342109007517	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109007518	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
342109007519	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
342109007520	active site
342109007521	catalytic triad [active]
342109007522	oxyanion hole [active]
342109007523	Autotransporter beta-domain; Region: Autotransporter; cl02365
342109007524	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
342109007525	thiS-thiF/thiG interaction site; other site
342109007526	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
342109007527	ThiS interaction site; other site
342109007528	putative active site [active]
342109007529	tetramer interface [polypeptide binding]; other site
342109007530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109007531	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
342109007532	transmembrane helices; other site
342109007533	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
342109007534	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
342109007535	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
342109007536	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467
342109007537	iron-sulfur cluster [ion binding]; other site
342109007538	[2Fe-2S] cluster binding site [ion binding]; other site
342109007539	Transposase domain (DUF772); Region: DUF772; cl12084
342109007540	Integrase core domain; Region: rve; cl01316
342109007541	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
342109007542	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
342109007543	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007544	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007545	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109007546	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109007547	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109007548	substrate binding pocket [chemical binding]; other site
342109007549	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109007550	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
342109007551	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
342109007552	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
342109007553	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109007554	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109007555	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
342109007556	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
342109007557	Zn binding site [ion binding]; other site
342109007558	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
342109007559	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
342109007560	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
342109007561	CysN_ATPS subfamily.  CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes.  ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate.  CysD, which...; Region: CysN_ATPS; cd04166
342109007562	CysD dimerization site [polypeptide binding]; other site
342109007563	G1 box; other site
342109007564	putative GEF interaction site [polypeptide binding]; other site
342109007565	GTP/Mg2+ binding site [chemical binding]; other site
342109007566	Switch I region; other site
342109007567	G2 box; other site
342109007568	G3 box; other site
342109007569	Switch II region; other site
342109007570	G4 box; other site
342109007571	G5 box; other site
342109007572	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695
342109007573	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095
342109007574	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027
342109007575	ligand-binding site [chemical binding]; other site
342109007576	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
342109007577	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
342109007578	Active Sites [active]
342109007579	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
342109007580	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
342109007581	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
342109007582	FAD binding pocket [chemical binding]; other site
342109007583	FAD binding motif [chemical binding]; other site
342109007584	catalytic residues [active]
342109007585	NAD binding pocket [chemical binding]; other site
342109007586	phosphate binding motif [ion binding]; other site
342109007587	beta-alpha-beta structure motif; other site
342109007588	sulfite reductase subunit beta; Provisional; Region: PRK13504
342109007589	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
342109007590	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
342109007591	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
342109007592	Active Sites [active]
342109007593	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
342109007594	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
342109007595	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
342109007596	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109007597	N-terminal plug; other site
342109007598	ligand-binding site [chemical binding]; other site
342109007599	GAF domain; Region: GAF; cl00853
342109007600	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
342109007601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109007602	ATP binding site [chemical binding]; other site
342109007603	Mg2+ binding site [ion binding]; other site
342109007604	G-X-G motif; other site
342109007605	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12680
342109007606	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109007607	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109007608	dimerization interface [polypeptide binding]; other site
342109007609	siroheme synthase; Provisional; Region: cysG; PRK10637
342109007610	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
342109007611	cysteine synthases; Region: cysKM; TIGR01136
342109007612	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
342109007613	dimer interface [polypeptide binding]; other site
342109007614	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109007615	catalytic residue [active]
342109007616	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
342109007617	Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908
342109007618	putative ADP-ribose binding site [chemical binding]; other site
342109007619	putative active site [active]
342109007620	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
342109007621	active site
342109007622	intersubunit interface [polypeptide binding]; other site
342109007623	catalytic residue [active]
342109007624	pyruvate kinase; Provisional; Region: PRK05826
342109007625	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
342109007626	domain interfaces; other site
342109007627	active site
342109007628	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
342109007629	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
342109007630	motif II; other site
342109007631	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
342109007632	substrate binding site [chemical binding]; other site
342109007633	hinge regions; other site
342109007634	ADP binding site [chemical binding]; other site
342109007635	catalytic site [active]
342109007636	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
342109007637	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
342109007638	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
342109007639	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
342109007640	tetramer interface [polypeptide binding]; other site
342109007641	heme binding pocket [chemical binding]; other site
342109007642	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
342109007643	domain interactions; other site
342109007644	Transposase domain (DUF772); Region: DUF772; cl12084
342109007645	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109007646	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109007647	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109007648	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109007649	Integrase core domain; Region: rve; cl01316
342109007650	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
342109007651	PAS fold; Region: PAS_4; pfam08448
342109007652	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
342109007653	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
342109007654	Transposase domain (DUF772); Region: DUF772; cl12084
342109007655	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109007656	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109007657	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
342109007658	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
342109007659	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109007660	Transposase domain (DUF772); Region: DUF772; cl12084
342109007661	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109007662	OPT oligopeptide transporter protein; Region: OPT; cl14607
342109007663	putative oligopeptide transporter, OPT family; Region: TIGR00733
342109007664	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
342109007665	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
342109007666	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
342109007667	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
342109007668	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
342109007669	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
342109007670	generic binding surface I; other site
342109007671	generic binding surface II; other site
342109007672	DNA Polymerase Y-family; Region: PolY_like; cd03468
342109007673	active site
342109007674	DNA binding site [nucleotide binding]
342109007675	Cell division inhibitor SulA; Region: SulA; cl01880
342109007676	LexA repressor; Provisional; Region: PRK12423
342109007677	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109007678	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
342109007679	Catalytic site [active]
342109007680	SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877
342109007681	Fic/DOC family; Region: Fic; cl00960
342109007682	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007683	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109007684	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007685	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192
342109007686	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
342109007687	catalytic core [active]
342109007688	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342109007689	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342109007690	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
342109007691	active site
342109007692	ATP binding site [chemical binding]; other site
342109007693	substrate binding site [chemical binding]; other site
342109007694	activation loop (A-loop); other site
342109007695	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
342109007696	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
342109007697	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
342109007698	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
342109007699	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
342109007700	Transposase domain (DUF772); Region: DUF772; cl12084
342109007701	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109007702	Transposase domain (DUF772); Region: DUF772; cl12084
342109007703	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109007704	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
342109007705	active site
342109007706	NTP binding site [chemical binding]; other site
342109007707	metal binding triad [ion binding]; metal-binding site
342109007708	antibiotic binding site [chemical binding]; other site
342109007709	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495
342109007710	HsdM N-terminal domain; Region: HsdM_N; pfam12161
342109007711	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
342109007712	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109007713	Uncharacterized conserved protein [Function unknown]; Region: COG4127
342109007714	Restriction endonuclease; Region: Mrr_cat; cl00747
342109007715	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
342109007716	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
342109007717	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
342109007718	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342109007719	ATP binding site [chemical binding]; other site
342109007720	putative Mg++ binding site [ion binding]; other site
342109007721	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
342109007722	Abi-like protein; Region: Abi_2; cl01988
342109007723	HsdM N-terminal domain; Region: HsdM_N; pfam12161
342109007724	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
342109007725	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
342109007726	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
342109007727	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
342109007728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
342109007729	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109007730	Integrase core domain; Region: rve; cl01316
342109007731	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109007732	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109007733	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109007734	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
342109007735	Clp amino terminal domain; Region: Clp_N; pfam02861
342109007736	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109007737	Walker A motif; other site
342109007738	ATP binding site [chemical binding]; other site
342109007739	Walker B motif; other site
342109007740	arginine finger; other site
342109007741	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109007742	Walker A motif; other site
342109007743	ATP binding site [chemical binding]; other site
342109007744	Walker B motif; other site
342109007745	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
342109007746	Protein of unknown function (DUF1305); Region: DUF1305; cl01404
342109007747	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
342109007748	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
342109007749	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
342109007750	Protein of unknown function (DUF796); Region: DUF796; cl01226
342109007751	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
342109007752	Protein of unknown function (DUF877); Region: DUF877; pfam05943
342109007753	Protein of unknown function (DUF770); Region: DUF770; cl01402
342109007754	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109007755	binding surface
342109007756	TPR motif; other site
342109007757	Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405
342109007758	Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406
342109007759	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
342109007760	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
342109007761	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109007762	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109007763	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109007764	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109007765	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109007766	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
342109007767	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109007768	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109007769	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109007770	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109007771	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
342109007772	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
342109007773	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109007774	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
342109007775	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109007776	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109007777	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109007778	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
342109007779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
342109007780	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109007781	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109007782	hypothetical protein; Provisional; Region: PRK11383
342109007783	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
342109007784	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
342109007785	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
342109007786	ligand binding site [chemical binding]; other site
342109007787	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
342109007788	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
342109007789	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
342109007790	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
342109007791	3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147
342109007792	PAAR motif; Region: PAAR_motif; pfam05488
342109007793	PAAR motif; Region: PAAR_motif; pfam05488
342109007794	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
342109007795	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109007796	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
342109007797	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109007798	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109007799	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
342109007800	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
342109007801	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
342109007802	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
342109007803	endonuclease III; Region: ENDO3c; smart00478
342109007804	minor groove reading motif; other site
342109007805	helix-hairpin-helix signature motif; other site
342109007806	substrate binding pocket [chemical binding]; other site
342109007807	active site
342109007808	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
342109007809	putative hydrophobic ligand binding site [chemical binding]; other site
342109007810	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406
342109007811	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
342109007812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109007813	active site
342109007814	phosphorylation site [posttranslational modification]
342109007815	intermolecular recognition site; other site
342109007816	dimerization interface [polypeptide binding]; other site
342109007817	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
342109007818	DNA binding residues [nucleotide binding]
342109007819	dimerization interface [polypeptide binding]; other site
342109007820	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
342109007821	Histidine kinase; Region: HisKA_3; pfam07730
342109007822	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
342109007823	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109007824	septum formation inhibitor; Reviewed; Region: minC; PRK04596
342109007825	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
342109007826	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
342109007827	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
342109007828	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036
342109007829	Switch I; other site
342109007830	Switch II; other site
342109007831	Septum formation topological specificity factor MinE; Region: MinE; cl00538
342109007832	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
342109007833	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109007834	dimer interface [polypeptide binding]; other site
342109007835	phosphorylation site [posttranslational modification]
342109007836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109007837	ATP binding site [chemical binding]; other site
342109007838	Mg2+ binding site [ion binding]; other site
342109007839	G-X-G motif; other site
342109007840	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
342109007841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109007842	active site
342109007843	phosphorylation site [posttranslational modification]
342109007844	intermolecular recognition site; other site
342109007845	dimerization interface [polypeptide binding]; other site
342109007846	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109007847	DNA binding site [nucleotide binding]
342109007848	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
342109007849	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
342109007850	active site
342109007851	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
342109007852	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
342109007853	Sulfatase; Region: Sulfatase; cl10460
342109007854	Angiotensin-converting enzyme; Region: Peptidase_M2; pfam01401
342109007855	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
342109007856	active site
342109007857	Zn binding site [ion binding]; other site
342109007858	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
342109007859	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
342109007860	putative active site [active]
342109007861	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
342109007862	This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain.  They export...; Region: ABCC_Protease_Secretion; cd03246
342109007863	Walker A/P-loop; other site
342109007864	ATP binding site [chemical binding]; other site
342109007865	Q-loop/lid; other site
342109007866	ABC transporter signature motif; other site
342109007867	Walker B; other site
342109007868	D-loop; other site
342109007869	H-loop/switch region; other site
342109007870	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
342109007871	glycine dehydrogenase; Provisional; Region: PRK05367
342109007872	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109007873	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109007874	catalytic residue [active]
342109007875	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613
342109007876	tetramer interface [polypeptide binding]; other site
342109007877	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109007878	catalytic residue [active]
342109007879	VRR-NUC domain; Region: VRR_NUC; pfam08774
342109007880	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
342109007881	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
342109007882	Integrase core domain; Region: rve; cl01316
342109007883	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109007884	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109007885	Integrase core domain; Region: rve; cl01316
342109007886	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007887	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109007888	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109007889	Integrase core domain; Region: rve; cl01316
342109007890	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
342109007891	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
342109007892	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
342109007893	alphaNTD homodimer interface [polypeptide binding]; other site
342109007894	alphaNTD - beta interaction site [polypeptide binding]; other site
342109007895	alphaNTD - beta' interaction site [polypeptide binding]; other site
342109007896	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
342109007897	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
342109007898	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
342109007899	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
342109007900	RNA binding surface [nucleotide binding]; other site
342109007901	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
342109007902	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
342109007903	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
342109007904	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
342109007905	SecY translocase; Region: SecY; pfam00344
342109007906	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
342109007907	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658
342109007908	23S rRNA binding site [nucleotide binding]; other site
342109007909	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
342109007910	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
342109007911	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
342109007912	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
342109007913	5S rRNA interface [nucleotide binding]; other site
342109007914	23S rRNA interface [nucleotide binding]; other site
342109007915	L5 interface [polypeptide binding]; other site
342109007916	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
342109007917	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
342109007918	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
342109007919	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
342109007920	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
342109007921	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
342109007922	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
342109007923	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
342109007924	KOW motif; Region: KOW; cl00354
342109007925	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
342109007926	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
342109007927	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427
342109007928	putative translocon interaction site; other site
342109007929	23S rRNA interface [nucleotide binding]; other site
342109007930	signal recognition particle (SRP54) interaction site; other site
342109007931	L23 interface [polypeptide binding]; other site
342109007932	trigger factor interaction site; other site
342109007933	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
342109007934	23S rRNA interface [nucleotide binding]; other site
342109007935	5S rRNA interface [nucleotide binding]; other site
342109007936	putative antibiotic binding site [chemical binding]; other site
342109007937	L25 interface [polypeptide binding]; other site
342109007938	L27 interface [polypeptide binding]; other site
342109007939	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
342109007940	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The...; Region: 30S_S3_KH; cd02412
342109007941	G-X-X-G motif; other site
342109007942	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
342109007943	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
342109007944	putative translocon binding site; other site
342109007945	protein-rRNA interface [nucleotide binding]; other site
342109007946	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
342109007947	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
342109007948	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
342109007949	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
342109007950	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
342109007951	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
342109007952	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
342109007953	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
342109007954	elongation factor Tu; Reviewed; Region: PRK00049
342109007955	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
342109007956	G1 box; other site
342109007957	GEF interaction site [polypeptide binding]; other site
342109007958	GTP/Mg2+ binding site [chemical binding]; other site
342109007959	Switch I region; other site
342109007960	G2 box; other site
342109007961	G3 box; other site
342109007962	Switch II region; other site
342109007963	G4 box; other site
342109007964	G5 box; other site
342109007965	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
342109007966	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
342109007967	Antibiotic Binding Site [chemical binding]; other site
342109007968	elongation factor G; Reviewed; Region: PRK00007
342109007969	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
342109007970	G1 box; other site
342109007971	putative GEF interaction site [polypeptide binding]; other site
342109007972	GTP/Mg2+ binding site [chemical binding]; other site
342109007973	Switch I region; other site
342109007974	G2 box; other site
342109007975	G3 box; other site
342109007976	Switch II region; other site
342109007977	G4 box; other site
342109007978	G5 box; other site
342109007979	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
342109007980	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
342109007981	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
342109007982	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
342109007983	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
342109007984	S17 interaction site [polypeptide binding]; other site
342109007985	S8 interaction site; other site
342109007986	16S rRNA interaction site [nucleotide binding]; other site
342109007987	streptomycin interaction site [chemical binding]; other site
342109007988	23S rRNA interaction site [nucleotide binding]; other site
342109007989	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
342109007990	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
342109007991	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
342109007992	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
342109007993	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
342109007994	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
342109007995	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
342109007996	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
342109007997	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
342109007998	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
342109007999	DNA binding site [nucleotide binding]
342109008000	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
342109008001	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
342109008002	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
342109008003	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591
342109008004	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
342109008005	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
342109008006	RPB11 interaction site [polypeptide binding]; other site
342109008007	RPB12 interaction site [polypeptide binding]; other site
342109008008	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
342109008009	RPB3 interaction site [polypeptide binding]; other site
342109008010	RPB1 interaction site [polypeptide binding]; other site
342109008011	RPB11 interaction site [polypeptide binding]; other site
342109008012	RPB10 interaction site [polypeptide binding]; other site
342109008013	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
342109008014	core dimer interface [polypeptide binding]; other site
342109008015	peripheral dimer interface [polypeptide binding]; other site
342109008016	L10 interface [polypeptide binding]; other site
342109008017	L11 interface [polypeptide binding]; other site
342109008018	putative EF-Tu interaction site [polypeptide binding]; other site
342109008019	putative EF-G interaction site [polypeptide binding]; other site
342109008020	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797
342109008021	23S rRNA interface [nucleotide binding]; other site
342109008022	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
342109008023	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403
342109008024	mRNA/rRNA interface [nucleotide binding]; other site
342109008025	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
342109008026	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
342109008027	23S rRNA interface [nucleotide binding]; other site
342109008028	L7/L12 interface [polypeptide binding]; other site
342109008029	putative thiostrepton binding site; other site
342109008030	L25 interface [polypeptide binding]; other site
342109008031	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
342109008032	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
342109008033	putative homodimer interface [polypeptide binding]; other site
342109008034	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
342109008035	elongation factor Tu; Reviewed; Region: PRK00049
342109008036	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
342109008037	G1 box; other site
342109008038	GEF interaction site [polypeptide binding]; other site
342109008039	GTP/Mg2+ binding site [chemical binding]; other site
342109008040	Switch I region; other site
342109008041	G2 box; other site
342109008042	G3 box; other site
342109008043	Switch II region; other site
342109008044	G4 box; other site
342109008045	G5 box; other site
342109008046	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
342109008047	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
342109008048	Antibiotic Binding Site [chemical binding]; other site
342109008049	GTP-binding protein YchF; Reviewed; Region: PRK09601
342109008050	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
342109008051	G1 box; other site
342109008052	GTP/Mg2+ binding site [chemical binding]; other site
342109008053	Switch I region; other site
342109008054	G2 box; other site
342109008055	Switch II region; other site
342109008056	G3 box; other site
342109008057	G4 box; other site
342109008058	G5 box; other site
342109008059	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
342109008060	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
342109008061	putative active site [active]
342109008062	catalytic residue [active]
342109008063	Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495
342109008064	5S rRNA interface [nucleotide binding]; other site
342109008065	CTC domain interface; other site
342109008066	L16 interface [polypeptide binding]; other site
342109008067	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923
342109008068	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
342109008069	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
342109008070	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
342109008071	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
342109008072	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
342109008073	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109008074	TPR motif; other site
342109008075	binding surface
342109008076	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109008077	binding surface
342109008078	TPR motif; other site
342109008079	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
342109008080	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
342109008081	tRNA; other site
342109008082	putative tRNA binding site [nucleotide binding]; other site
342109008083	putative NADP binding site [chemical binding]; other site
342109008084	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
342109008085	peptide chain release factor 1; Validated; Region: prfA; PRK00591
342109008086	RF-1 domain; Region: RF-1; cl02875
342109008087	RF-1 domain; Region: RF-1; cl02875
342109008088	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
342109008089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109008090	binding surface
342109008091	TPR motif; other site
342109008092	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
342109008093	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886
342109008094	MPT binding site; other site
342109008095	trimer interface [polypeptide binding]; other site
342109008096	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
342109008097	Acylphosphatase; Region: Acylphosphatase; cl00551
342109008098	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966
342109008099	catalytic residues [active]
342109008100	ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214
342109008101	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
342109008102	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
342109008103	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
342109008104	Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one  highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216
342109008105	active site/substrate binding site [active]
342109008106	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX.  The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
342109008107	putative deacylase active site [active]
342109008108	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
342109008109	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
342109008110	active site
342109008111	catalytic residues [active]
342109008112	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
342109008113	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557
342109008114	homodimer interface [polypeptide binding]; other site
342109008115	substrate-cofactor binding pocket; other site
342109008116	catalytic residue [active]
342109008117	Domain of unknown function DUF59; Region: DUF59; cl00941
342109008118	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008119	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109008120	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008121	NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566
342109008122	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
342109008123	RNA polymerase factor sigma-70; Validated; Region: PRK09047
342109008124	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
342109008125	DNA binding residues [nucleotide binding]
342109008126	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
342109008127	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
342109008128	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222
342109008129	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
342109008130	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
342109008131	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135
342109008132	putative FMN binding site [chemical binding]; other site
342109008133	5'-3' exonuclease; Region: 53EXOc; smart00475
342109008134	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
342109008135	active site
342109008136	metal binding site 1 [ion binding]; metal-binding site
342109008137	putative 5' ssDNA interaction site; other site
342109008138	metal binding site 3; metal-binding site
342109008139	metal binding site 2 [ion binding]; metal-binding site
342109008140	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
342109008141	putative DNA binding site [nucleotide binding]; other site
342109008142	putative metal binding site [ion binding]; other site
342109008143	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
342109008144	ADP-ribose binding site [chemical binding]; other site
342109008145	dimer interface [polypeptide binding]; other site
342109008146	active site
342109008147	nudix motif; other site
342109008148	metal binding site [ion binding]; metal-binding site
342109008149	N-formylglutamate amidohydrolase; Region: FGase; cl01522
342109008150	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
342109008151	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109008152	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109008153	Integrase core domain; Region: rve; cl01316
342109008154	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
342109008155	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109008156	S-adenosylmethionine binding site [chemical binding]; other site
342109008157	peroxiredoxin; Region: AhpC; TIGR03137
342109008158	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015
342109008159	dimer interface [polypeptide binding]; other site
342109008160	decamer (pentamer of dimers) interface [polypeptide binding]; other site
342109008161	catalytic triad [active]
342109008162	peroxidatic and resolving cysteines [active]
342109008163	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
342109008164	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974
342109008165	catalytic residue [active]
342109008166	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
342109008167	catalytic residues [active]
342109008168	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109008169	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
342109008170	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109008171	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
342109008172	dimerization interface [polypeptide binding]; other site
342109008173	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
342109008174	C-term; Region: GreA_GreB; pfam01272
342109008175	transaldolase-like protein; Provisional; Region: PTZ00411
342109008176	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
342109008177	active site
342109008178	dimer interface [polypeptide binding]; other site
342109008179	catalytic residue [active]
342109008180	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109008181	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109008182	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109008183	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
342109008184	conserved cys residue [active]
342109008185	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
342109008186	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
342109008187	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109008188	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008189	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
342109008190	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
342109008191	GSH binding site [chemical binding]; other site
342109008192	catalytic residues [active]
342109008193	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
342109008194	Peptidase family M48; Region: Peptidase_M48; cl12018
342109008195	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
342109008196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109008197	active site
342109008198	phosphorylation site [posttranslational modification]
342109008199	intermolecular recognition site; other site
342109008200	dimerization interface [polypeptide binding]; other site
342109008201	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109008202	DNA binding site [nucleotide binding]
342109008203	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
342109008204	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
342109008205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109008206	dimer interface [polypeptide binding]; other site
342109008207	phosphorylation site [posttranslational modification]
342109008208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109008209	ATP binding site [chemical binding]; other site
342109008210	Mg2+ binding site [ion binding]; other site
342109008211	G-X-G motif; other site
342109008212	polyphosphate kinase; Provisional; Region: PRK05443
342109008213	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
342109008214	putative domain interface [polypeptide binding]; other site
342109008215	putative active site [active]
342109008216	catalytic site [active]
342109008217	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
342109008218	putative domain interface [polypeptide binding]; other site
342109008219	putative active site [active]
342109008220	catalytic site [active]
342109008221	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
342109008222	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
342109008223	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
342109008224	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814
342109008225	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
342109008226	active site
342109008227	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
342109008228	putative active site [active]
342109008229	putative metal binding site [ion binding]; other site
342109008230	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
342109008231	dinuclear metal binding motif [ion binding]; other site
342109008232	amidophosphoribosyltransferase; Provisional; Region: PRK09246
342109008233	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
342109008234	active site
342109008235	tetramer interface [polypeptide binding]; other site
342109008236	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
342109008237	Colicin V production protein; Region: Colicin_V; cl00567
342109008238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
342109008239	Sporulation related domain; Region: SPOR; cl10051
342109008240	Sporulation related domain; Region: SPOR; cl10051
342109008241	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
342109008242	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
342109008243	catalytic core [active]
342109008244	Peptidase S46; Region: Peptidase_S46; pfam10459
342109008245	Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949
342109008246	Phosphoesterase family; Region: Phosphoesterase; cl10627
342109008247	Domain of unknown function (DUF756); Region: DUF756; pfam05506
342109008248	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
342109008249	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
342109008250	N-terminal plug; other site
342109008251	ligand-binding site [chemical binding]; other site
342109008252	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
342109008253	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
342109008254	NAD(P) binding site [chemical binding]; other site
342109008255	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
342109008256	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
342109008257	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296
342109008258	Walker A/P-loop; other site
342109008259	ATP binding site [chemical binding]; other site
342109008260	Q-loop/lid; other site
342109008261	ABC transporter signature motif; other site
342109008262	Walker B; other site
342109008263	D-loop; other site
342109008264	H-loop/switch region; other site
342109008265	TOBE-like domain; Region: TOBE_3; pfam12857
342109008266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
342109008267	dimer interface [polypeptide binding]; other site
342109008268	conserved gate region; other site
342109008269	putative PBP binding loops; other site
342109008270	ABC-ATPase subunit interface; other site
342109008271	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
342109008272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
342109008273	dimer interface [polypeptide binding]; other site
342109008274	conserved gate region; other site
342109008275	putative PBP binding loops; other site
342109008276	ABC-ATPase subunit interface; other site
342109008277	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109008278	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
342109008279	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454
342109008280	substrate-cofactor binding pocket; other site
342109008281	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109008282	catalytic residue [active]
342109008283	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
342109008284	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
342109008285	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
342109008286	active site
342109008287	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
342109008288	ligand binding site [chemical binding]; other site
342109008289	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
342109008290	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
342109008291	putative NAD(P) binding site [chemical binding]; other site
342109008292	dimer interface [polypeptide binding]; other site
342109008293	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
342109008294	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
342109008295	active site
342109008296	FMN binding site [chemical binding]; other site
342109008297	2,4-decadienoyl-CoA binding site; other site
342109008298	catalytic residue [active]
342109008299	4Fe-4S cluster binding site [ion binding]; other site
342109008300	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109008301	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109008302	Integrase core domain; Region: rve; cl01316
342109008303	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
342109008304	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008305	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109008306	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109008308	ATP binding site [chemical binding]; other site
342109008309	Mg2+ binding site [ion binding]; other site
342109008310	G-X-G motif; other site
342109008311	Response regulator receiver domain; Region: Response_reg; pfam00072
342109008312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109008313	active site
342109008314	phosphorylation site [posttranslational modification]
342109008315	intermolecular recognition site; other site
342109008316	dimerization interface [polypeptide binding]; other site
342109008317	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109008318	active site
342109008319	phosphorylation site [posttranslational modification]
342109008320	intermolecular recognition site; other site
342109008321	dimerization interface [polypeptide binding]; other site
342109008322	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH)...; Region: GST_N_1; cd03043
342109008323	putative C-terminal domain interface [polypeptide binding]; other site
342109008324	putative GSH binding site (G-site) [chemical binding]; other site
342109008325	putative dimer interface [polypeptide binding]; other site
342109008326	GST_C family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous...; Region: GST_C_3; cd03194
342109008327	putative substrate binding pocket (H-site) [chemical binding]; other site
342109008328	putative N-terminal domain interface [polypeptide binding]; other site
342109008329	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
342109008330	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
342109008331	active site
342109008332	HIGH motif; other site
342109008333	nucleotide binding site [chemical binding]; other site
342109008334	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
342109008335	active site
342109008336	KMSKS motif; other site
342109008337	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
342109008338	Integrase core domain; Region: rve; cl01316
342109008339	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008340	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008341	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109008342	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008343	EamA-like transporter family; Region: EamA; cl01037
342109008344	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
342109008345	nucleoside/Zn binding site; other site
342109008346	dimer interface [polypeptide binding]; other site
342109008347	catalytic motif [active]
342109008348	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
342109008349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109008350	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
342109008351	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109008352	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
342109008353	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
342109008354	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cl09501
342109008355	pseudo EF-hand loop; other site
342109008356	peptide binding pocket; other site
342109008357	Ca2+ binding site [ion binding]; other site
342109008358	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109008359	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
342109008360	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
342109008361	substrate binding site [chemical binding]; other site
342109008362	oxyanion hole (OAH) forming residues; other site
342109008363	trimer interface [polypeptide binding]; other site
342109008364	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
342109008365	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
342109008366	NAD binding site [chemical binding]; other site
342109008367	catalytic residues [active]
342109008368	acyl-CoA synthetase; Validated; Region: PRK09088
342109008369	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
342109008370	Transcriptional regulator [Transcription]; Region: LysR; COG0583
342109008371	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109008372	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109008373	dimerization interface [polypeptide binding]; other site
342109008374	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
342109008375	tetramer interface [polypeptide binding]; other site
342109008376	The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950
342109008377	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
342109008378	putative active site [active]
342109008379	Fe(II) binding site [ion binding]; other site
342109008380	putative dimer interface [polypeptide binding]; other site
342109008381	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109008382	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109008383	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109008384	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
342109008385	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Validated; Region: PRK08773
342109008386	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109008387	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109008388	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
342109008389	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
342109008390	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
342109008391	organic solvent tolerance protein; Provisional; Region: PRK04423
342109008392	Organic solvent tolerance protein; Region: OstA_C; pfam04453
342109008393	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
342109008394	SurA N-terminal domain; Region: SurA_N; pfam09312
342109008395	PPIC-type PPIASE domain; Region: Rotamase; cl08278
342109008396	PPIC-type PPIASE domain; Region: Rotamase; cl08278
342109008397	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
342109008398	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
342109008399	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109008400	Protein of unknown function (DUF525); Region: DUF525; cl01119
342109008401	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
342109008402	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
342109008403	active site
342109008404	metal binding site [ion binding]; metal-binding site
342109008405	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209
342109008406	folate binding site [chemical binding]; other site
342109008407	NADP+ binding site [chemical binding]; other site
342109008408	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
342109008409	dimerization interface [polypeptide binding]; other site
342109008410	active site
342109008411	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
342109008412	Domain of unknown function (DUF477); Region: DUF477; cl01535
342109008413	Domain of unknown function (DUF477); Region: DUF477; cl01535
342109008414	LemA family; Region: LemA; cl00742
342109008415	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
342109008416	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
342109008417	active site
342109008418	oxyanion hole [active]
342109008419	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109008420	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109008421	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
342109008422	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109008423	dimer interface [polypeptide binding]; other site
342109008424	phosphorylation site [posttranslational modification]
342109008425	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109008426	ATP binding site [chemical binding]; other site
342109008427	Mg2+ binding site [ion binding]; other site
342109008428	G-X-G motif; other site
342109008429	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
342109008430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109008431	active site
342109008432	phosphorylation site [posttranslational modification]
342109008433	intermolecular recognition site; other site
342109008434	dimerization interface [polypeptide binding]; other site
342109008435	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109008436	DNA binding site [nucleotide binding]
342109008437	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
342109008438	active site
342109008439	catalytic triad [active]
342109008440	oxyanion hole [active]
342109008441	switch loop; other site
342109008442	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
342109008443	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
342109008444	Walker A/P-loop; other site
342109008445	ATP binding site [chemical binding]; other site
342109008446	Q-loop/lid; other site
342109008447	ABC transporter signature motif; other site
342109008448	Walker B; other site
342109008449	D-loop; other site
342109008450	H-loop/switch region; other site
342109008451	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
342109008452	FtsX-like permease family; Region: FtsX; pfam02687
342109008453	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
342109008454	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
342109008455	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184
342109008456	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
342109008457	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
342109008458	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
342109008459	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
342109008460	Walker A/P-loop; other site
342109008461	ATP binding site [chemical binding]; other site
342109008462	Q-loop/lid; other site
342109008463	ABC transporter signature motif; other site
342109008464	Walker B; other site
342109008465	D-loop; other site
342109008466	H-loop/switch region; other site
342109008467	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
342109008468	Protein of unknown function, DUF486; Region: DUF486; cl01236
342109008469	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
342109008470	Hemin uptake protein hemP; Region: hemP; cl10043
342109008471	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
342109008472	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
342109008473	active site
342109008474	catalytic tetrad [active]
342109008475	nucleoside transporter; Region: nupC; TIGR00804
342109008476	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
342109008477	Nucleoside recognition; Region: Gate; cl00486
342109008478	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
342109008479	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174
342109008480	substrate binding site [chemical binding]; other site
342109008481	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
342109008482	dimer interface [polypeptide binding]; other site
342109008483	ATP binding site [chemical binding]; other site
342109008484	Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306
342109008485	Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307
342109008486	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
342109008487	putative metal binding site [ion binding]; other site
342109008488	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
342109008489	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
342109008490	FMN binding site [chemical binding]; other site
342109008491	active site
342109008492	catalytic residues [active]
342109008493	substrate binding site [chemical binding]; other site
342109008494	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109008495	S-adenosylmethionine binding site [chemical binding]; other site
342109008496	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
342109008497	S-adenosylmethionine synthetase; Validated; Region: PRK05250
342109008498	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
342109008499	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
342109008500	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
342109008501	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008502	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008503	phosphoanhydride phosphorylase; Provisional; Region: PRK10172
342109008504	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
342109008505	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109008506	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109008507	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109008508	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109008509	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342109008510	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342109008511	Phosphoenolpyruvate carboxylase [Carbohydrate transport and    metabolism; Energy production and conversion]; Region: COG1892; cl14656
342109008512	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
342109008513	Adenosylhomocysteinase; Provisional; Region: PTZ00075
342109008514	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401
342109008515	oligomerization interface [polypeptide binding]; other site
342109008516	active site
342109008517	NAD+ binding site [chemical binding]; other site
342109008518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109008519	S-adenosylmethionine binding site [chemical binding]; other site
342109008520	sulfotransferase; Region: PLN02164
342109008521	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
342109008522	Protein of unknown function (DUF3228); Region: DUF3228; pfam11539
342109008523	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201
342109008524	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
342109008525	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109008526	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
342109008527	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
342109008528	catalytic residues [active]
342109008529	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
342109008530	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
342109008531	NAD(P) binding site [chemical binding]; other site
342109008532	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895
342109008533	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537
342109008534	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
342109008535	FAD binding site [chemical binding]; other site
342109008536	hypothetical protein; Provisional; Region: PRK08999
342109008537	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
342109008538	active site
342109008539	8-oxo-dGMP binding site [chemical binding]; other site
342109008540	nudix motif; other site
342109008541	metal binding site [ion binding]; metal-binding site
342109008542	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564
342109008543	thiamine phosphate binding site [chemical binding]; other site
342109008544	active site
342109008545	pyrophosphate binding site [ion binding]; other site
342109008546	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_17; cd08356
342109008547	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
342109008548	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
342109008549	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
342109008550	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109008551	nucleotide binding region [chemical binding]; other site
342109008552	ATP-binding site [chemical binding]; other site
342109008553	SEC-C motif; Region: SEC-C; cl12132
342109008554	Peptidase family M23; Region: Peptidase_M23; pfam01551
342109008555	Protein of unknown function (DUF721); Region: DUF721; cl02324
342109008556	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
342109008557	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
342109008558	cell division protein FtsZ; Validated; Region: PRK09330
342109008559	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201
342109008560	nucleotide binding site [chemical binding]; other site
342109008561	SulA interaction site; other site
342109008562	cell division protein FtsA; Region: ftsA; TIGR01174
342109008563	Cell division protein FtsA; Region: FtsA; cl11496
342109008564	Cell division protein FtsA; Region: FtsA; cl11496
342109008565	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
342109008566	Cell division protein FtsQ; Region: FtsQ; pfam03799
342109008567	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
342109008568	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
342109008569	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109008570	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
342109008571	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
342109008572	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
342109008573	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
342109008574	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
342109008575	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785
342109008576	active site
342109008577	homodimer interface [polypeptide binding]; other site
342109008578	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
342109008579	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
342109008580	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852
342109008581	Mg++ binding site [ion binding]; other site
342109008582	putative catalytic motif [active]
342109008583	putative substrate binding site [chemical binding]; other site
342109008584	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
342109008585	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
342109008586	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
342109008587	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
342109008588	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
342109008589	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
342109008590	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
342109008591	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
342109008592	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
342109008593	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
342109008594	Septum formation initiator; Region: DivIC; cl11433
342109008595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109008596	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
342109008597	cell division protein MraZ; Reviewed; Region: PRK00326
342109008598	MraZ protein; Region: MraZ; pfam02381
342109008599	MraZ protein; Region: MraZ; pfam02381
342109008600	Protein of unknown function (DUF833); Region: DUF833; cl01315
342109008601	Post-segregation antitoxin CcdA; Region: CcdA; cl02188
342109008602	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
342109008603	Predicted methyltransferases [General function prediction only]; Region: COG0313
342109008604	LppC putative lipoprotein; Region: LppC; pfam04348
342109008605	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
342109008606	putative ligand binding site [chemical binding]; other site
342109008607	Uncharacterised protein family UPF0102; Region: UPF0102; cl00516
342109008608	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
342109008609	FAD binding domain; Region: FAD_binding_4; pfam01565
342109008610	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
342109008611	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
342109008612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109008613	active site
342109008614	phosphorylation site [posttranslational modification]
342109008615	intermolecular recognition site; other site
342109008616	dimerization interface [polypeptide binding]; other site
342109008617	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109008618	DNA binding site [nucleotide binding]
342109008619	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
342109008620	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
342109008621	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
342109008622	Ligand Binding Site [chemical binding]; other site
342109008623	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109008624	dimer interface [polypeptide binding]; other site
342109008625	phosphorylation site [posttranslational modification]
342109008626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109008627	ATP binding site [chemical binding]; other site
342109008628	Mg2+ binding site [ion binding]; other site
342109008629	G-X-G motif; other site
342109008630	K+-transporting ATPase, c chain; Region: KdpC; cl00944
342109008631	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
342109008632	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
342109008633	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
342109008634	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903
342109008635	Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814
342109008636	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
342109008637	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
342109008638	Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889
342109008639	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
342109008640	thiamine monophosphate kinase; Provisional; Region: PRK05731
342109008641	ATP binding site [chemical binding]; other site
342109008642	dimerization interface [polypeptide binding]; other site
342109008643	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
342109008644	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
342109008645	homopentamer interface [polypeptide binding]; other site
342109008646	active site
342109008647	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
342109008648	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
342109008649	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
342109008650	dimerization interface [polypeptide binding]; other site
342109008651	active site
342109008652	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
342109008653	Lumazine binding domain; Region: Lum_binding; pfam00677
342109008654	Lumazine binding domain; Region: Lum_binding; pfam00677
342109008655	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
342109008656	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
342109008657	catalytic motif [active]
342109008658	Zn binding site [ion binding]; other site
342109008659	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
342109008660	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
342109008661	Coenzyme A binding pocket [chemical binding]; other site
342109008662	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109008663	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
342109008664	ATP cone domain; Region: ATP-cone; pfam03477
342109008665	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378
342109008666	dimer interface [polypeptide binding]; other site
342109008667	glycine-pyridoxal phosphate binding site [chemical binding]; other site
342109008668	active site
342109008669	folate binding site [chemical binding]; other site
342109008670	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
342109008671	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109008672	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
342109008673	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
342109008674	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109008675	Walker A/P-loop; other site
342109008676	ATP binding site [chemical binding]; other site
342109008677	Q-loop/lid; other site
342109008678	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
342109008679	ABC transporter signature motif; other site
342109008680	Walker B; other site
342109008681	D-loop; other site
342109008682	ABC transporter; Region: ABC_tran_2; pfam12848
342109008683	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
342109008684	Predicted esterase [General function prediction only]; Region: COG0627
342109008685	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109008686	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
342109008687	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
342109008688	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
342109008689	substrate binding site [chemical binding]; other site
342109008690	catalytic Zn binding site [ion binding]; other site
342109008691	NAD binding site [chemical binding]; other site
342109008692	structural Zn binding site [ion binding]; other site
342109008693	dimer interface [polypeptide binding]; other site
342109008694	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
342109008695	putative metal binding site [ion binding]; other site
342109008696	putative homotetramer interface [polypeptide binding]; other site
342109008697	putative homodimer interface [polypeptide binding]; other site
342109008698	putative homodimer-homodimer interface [polypeptide binding]; other site
342109008699	putative allosteric switch controlling residues; other site
342109008700	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
342109008701	osmolarity response regulator; Provisional; Region: ompR; PRK09468
342109008702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109008703	active site
342109008704	phosphorylation site [posttranslational modification]
342109008705	intermolecular recognition site; other site
342109008706	dimerization interface [polypeptide binding]; other site
342109008707	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109008708	DNA binding site [nucleotide binding]
342109008709	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
342109008710	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
342109008711	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109008712	dimer interface [polypeptide binding]; other site
342109008713	phosphorylation site [posttranslational modification]
342109008714	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109008715	ATP binding site [chemical binding]; other site
342109008716	Mg2+ binding site [ion binding]; other site
342109008717	G-X-G motif; other site
342109008718	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
342109008719	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109008720	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
342109008721	dimer interface [polypeptide binding]; other site
342109008722	phosphorylation site [posttranslational modification]
342109008723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109008724	ATP binding site [chemical binding]; other site
342109008725	Mg2+ binding site [ion binding]; other site
342109008726	G-X-G motif; other site
342109008727	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
342109008728	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
342109008729	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008730	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008731	The YihA (EngB) subfamily.  This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control.  YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876
342109008732	G1 box; other site
342109008733	GTP/Mg2+ binding site [chemical binding]; other site
342109008734	Switch I region; other site
342109008735	G2 box; other site
342109008736	G3 box; other site
342109008737	Switch II region; other site
342109008738	G4 box; other site
342109008739	G5 box; other site
342109008740	Cytochrome c; Region: Cytochrom_C; cl11414
342109008741	Cytochrome c; Region: Cytochrom_C; cl11414
342109008742	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
342109008743	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
342109008744	catalytic residues [active]
342109008745	hinge region; other site
342109008746	alpha helical domain; other site
342109008747	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
342109008748	catalytic residues [active]
342109008749	hinge region; other site
342109008750	alpha helical domain; other site
342109008751	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
342109008752	putative catalytic site [active]
342109008753	putative metal binding site [ion binding]; other site
342109008754	putative phosphate binding site [ion binding]; other site
342109008755	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
342109008756	putative catalytic site [active]
342109008757	putative phosphate binding site [ion binding]; other site
342109008758	putative metal binding site [ion binding]; other site
342109008759	BCCT family transporter; Region: BCCT; cl00569
342109008760	Integrase core domain; Region: rve; cl01316
342109008761	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109008762	Transposase domain (DUF772); Region: DUF772; cl12084
342109008763	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109008764	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
342109008765	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
342109008766	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109008767	catalytic residue [active]
342109008768	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109008769	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109008770	catalytic residue [active]
342109008771	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008772	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008773	Transposase domain (DUF772); Region: DUF772; cl12084
342109008774	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109008775	Transposase domain (DUF772); Region: DUF772; cl12084
342109008776	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109008777	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109008778	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109008779	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109008780	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008781	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109008782	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
342109008783	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
342109008784	active site
342109008785	NTP binding site [chemical binding]; other site
342109008786	metal binding triad [ion binding]; metal-binding site
342109008787	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
342109008788	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109008789	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109008790	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109008791	Integrase core domain; Region: rve; cl01316
342109008792	Transposase domain (DUF772); Region: DUF772; cl12084
342109008793	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109008794	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008795	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109008796	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109008797	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109008798	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109008799	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109008800	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109008801	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
342109008802	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109008803	binding surface
342109008804	TPR motif; other site
342109008805	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
342109008806	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
342109008807	N-glycosyltransferase; Provisional; Region: PRK11204
342109008808	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
342109008809	DXD motif; other site
342109008810	hemin storage system protein; Provisional; Region: hmsS; cl14676
342109008811	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
342109008812	active site
342109008813	dimer interface [polypeptide binding]; other site
342109008814	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
342109008815	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
342109008816	dimer interface [polypeptide binding]; other site
342109008817	active site
342109008818	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
342109008819	dimer interface [polypeptide binding]; other site
342109008820	active site
342109008821	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342109008822	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342109008823	DNA binding site [nucleotide binding]
342109008824	domain linker motif; other site
342109008825	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
342109008826	putative dimerization interface [polypeptide binding]; other site
342109008827	putative ligand binding site [chemical binding]; other site
342109008828	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
342109008829	glucose/galactose transporter; Region: gluP; TIGR01272
342109008830	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
342109008831	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
342109008832	DNA-binding site [nucleotide binding]; DNA binding site
342109008833	UTRA domain; Region: UTRA; cl06649
342109008834	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
342109008835	Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089
342109008836	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972
342109008837	Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971
342109008838	Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089
342109008839	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
342109008840	domain; Region: Glyco_hydro_2; pfam00703
342109008841	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895
342109008842	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109008843	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109008844	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109008845	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109008846	Integrase core domain; Region: rve; cl01316
342109008847	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109008848	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109008849	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109008850	putative transposase OrfB; Reviewed; Region: PHA02517
342109008851	Integrase core domain; Region: rve; cl01316
342109008852	Uncharacterized conserved protein [Function unknown]; Region: COG1565
342109008853	Uncharacterized ACR, COG1565; Region: DUF185; pfam02636
342109008854	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
342109008855	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109008856	NAD(P) binding site [chemical binding]; other site
342109008857	active site
342109008858	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
342109008859	catalytic center binding site [active]
342109008860	ATP binding site [chemical binding]; other site
342109008861	Response regulator receiver domain; Region: Response_reg; pfam00072
342109008862	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109008863	active site
342109008864	phosphorylation site [posttranslational modification]
342109008865	intermolecular recognition site; other site
342109008866	dimerization interface [polypeptide binding]; other site
342109008867	two-component VirA-like sensor kinase; Provisional; Region: PRK13837
342109008868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109008869	ATP binding site [chemical binding]; other site
342109008870	Mg2+ binding site [ion binding]; other site
342109008871	G-X-G motif; other site
342109008872	Response regulator receiver domain; Region: Response_reg; pfam00072
342109008873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109008874	active site
342109008875	phosphorylation site [posttranslational modification]
342109008876	intermolecular recognition site; other site
342109008877	dimerization interface [polypeptide binding]; other site
342109008878	CHASE3 domain; Region: CHASE3; cl05000
342109008879	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
342109008880	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109008881	dimer interface [polypeptide binding]; other site
342109008882	phosphorylation site [posttranslational modification]
342109008883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109008884	ATP binding site [chemical binding]; other site
342109008885	Mg2+ binding site [ion binding]; other site
342109008886	G-X-G motif; other site
342109008887	BON domain; Region: BON; cl02771
342109008888	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109008889	putative oxidoreductase; Provisional; Region: PRK11579
342109008890	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
342109008891	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
342109008892	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109008893	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
342109008894	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109008895	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
342109008896	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general...; Region: PBEF_like; cd01569
342109008897	active site
342109008898	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
342109008899	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168
342109008900	active site
342109008901	(T/H)XGH motif; other site
342109008902	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
342109008903	nudix motif; other site
342109008904	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
342109008905	putative catalytic site [active]
342109008906	putative metal binding site [ion binding]; other site
342109008907	putative phosphate binding site [ion binding]; other site
342109008908	carboxy-terminal protease; Provisional; Region: PRK11186
342109008909	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
342109008910	protein binding site [polypeptide binding]; other site
342109008911	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
342109008912	Catalytic dyad [active]
342109008913	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
342109008914	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
342109008915	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109008916	lipoyl synthase; Provisional; Region: PRK05481
342109008917	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
342109008918	FeS/SAM binding site; other site
342109008919	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
342109008920	Protein of unknown function (DUF493); Region: DUF493; cl01102
342109008921	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
342109008922	Beta-lactamase; Region: Beta-lactamase; cl01009
342109008923	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
342109008924	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
342109008925	Sporulation related domain; Region: SPOR; cl10051
342109008926	lytic murein transglycosylase; Region: MltB_2; TIGR02283
342109008927	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
342109008928	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
342109008929	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
342109008930	putative peptidoglycan binding site; other site
342109008931	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
342109008932	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109008933	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109008934	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109008935	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
342109008936	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109008937	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
342109008938	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
342109008939	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
342109008940	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
342109008941	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
342109008942	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
342109008943	rod shape-determining protein MreD; Region: MreD; cl01087
342109008944	rod shape-determining protein MreC; Region: MreC; pfam04085
342109008945	rod shape-determining protein MreB; Provisional; Region: PRK13927
342109008946	Cell division protein FtsA; Region: FtsA; cl11496
342109008947	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
342109008948	substrate binding site [chemical binding]; other site
342109008949	ATP binding site [chemical binding]; other site
342109008950	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
342109008951	motif II; other site
342109008952	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
342109008953	nucleoside/Zn binding site; other site
342109008954	dimer interface [polypeptide binding]; other site
342109008955	catalytic motif [active]
342109008956	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109008957	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109008958	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
342109008959	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
342109008960	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
342109008961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109008962	S-adenosylmethionine binding site [chemical binding]; other site
342109008963	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109008964	metal binding site [ion binding]; metal-binding site
342109008965	active site
342109008966	I-site; other site
342109008967	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
342109008968	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
342109008969	active site
342109008970	Zn binding site [ion binding]; other site
342109008971	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
342109008972	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
342109008973	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
342109008974	active site
342109008975	motif I; other site
342109008976	motif II; other site
342109008977	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
342109008978	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109008979	Walker A motif; other site
342109008980	ATP binding site [chemical binding]; other site
342109008981	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109008982	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467
342109008983	active site
342109008984	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
342109008985	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
342109008986	DNA binding site [nucleotide binding]
342109008987	Int/Topo IB signature motif; other site
342109008988	active site
342109008989	Protein of unknown function, DUF484; Region: DUF484; cl01228
342109008990	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
342109008991	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
342109008992	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
342109008993	Protein of unknown function (DUF454); Region: DUF454; cl01063
342109008994	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
342109008995	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109008996	aspartate aminotransferase; Provisional; Region: PRK08361
342109008997	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
342109008998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
342109008999	homodimer interface [polypeptide binding]; other site
342109009000	catalytic residue [active]
342109009001	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
342109009002	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109009003	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
342109009004	Predicted transcriptional regulator [Transcription]; Region: COG2378
342109009005	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109009006	Protein of unknown function, DUF481; Region: DUF481; cl01213
342109009007	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
342109009008	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189
342109009009	domain interfaces; other site
342109009010	active site
342109009011	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
342109009012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109009013	active site
342109009014	phosphorylation site [posttranslational modification]
342109009015	intermolecular recognition site; other site
342109009016	dimerization interface [polypeptide binding]; other site
342109009017	LytTr DNA-binding domain; Region: LytTR; cl04498
342109009018	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
342109009019	Histidine kinase; Region: His_kinase; pfam06580
342109009020	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
342109009021	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109009022	Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943
342109009023	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
342109009024	Ligand binding site [chemical binding]; other site
342109009025	DXD motif; other site
342109009026	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009027	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009028	M28, and M42; Region: Zinc_peptidase_like; cl14876
342109009029	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-...; Region: PA_M28_1_2; cd04821
342109009030	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
342109009031	PA/protease or protease-like domain interface [polypeptide binding]; other site
342109009032	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
342109009033	metal binding site [ion binding]; metal-binding site
342109009034	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109009035	metal binding site [ion binding]; metal-binding site
342109009036	active site
342109009037	I-site; other site
342109009038	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
342109009039	Sulfate transporter family; Region: Sulfate_transp; cl00967
342109009040	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
342109009041	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895
342109009042	Cellulose binding domain; Region: CBM_2; cl02709
342109009043	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
342109009044	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
342109009045	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
342109009046	GAF domain; Region: GAF; cl00853
342109009047	PAS fold; Region: PAS; pfam00989
342109009048	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
342109009049	PAS domain S-box; Region: sensory_box; TIGR00229
342109009050	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342109009051	putative active site [active]
342109009052	heme pocket [chemical binding]; other site
342109009053	PAS domain S-box; Region: sensory_box; TIGR00229
342109009054	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
342109009055	putative active site [active]
342109009056	heme pocket [chemical binding]; other site
342109009057	PAS fold; Region: PAS_4; pfam08448
342109009058	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
342109009059	metal binding site [ion binding]; metal-binding site
342109009060	active site
342109009061	I-site; other site
342109009062	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
342109009063	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
342109009064	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
342109009065	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
342109009066	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
342109009067	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
342109009068	GAF domain; Region: GAF; cl00853
342109009069	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009070	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009071	Protein of unknown function DUF72; Region: DUF72; cl00777
342109009072	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
342109009073	Avidin family; Region: Avidin; pfam01382
342109009074	Protein of unknown function DUF124; Region: DUF124; cl00884
342109009075	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
342109009076	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
342109009077	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
342109009078	Amino acid permease; Region: AA_permease; pfam00324
342109009079	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
342109009080	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895
342109009081	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
342109009082	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
342109009083	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
342109009084	Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521
342109009085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109009086	S-adenosylmethionine binding site [chemical binding]; other site
342109009087	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109009088	Integrase core domain; Region: rve; cl01316
342109009089	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
342109009090	GAD-like domain; Region: GAD-like; pfam08887
342109009091	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
342109009092	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109009093	substrate binding pocket [chemical binding]; other site
342109009094	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
342109009095	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
342109009096	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109009097	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109009098	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109009099	active site
342109009100	protease 4; Provisional; Region: PRK10949
342109009101	putative transposase OrfB; Reviewed; Region: PHA02517
342109009102	Integrase core domain; Region: rve; cl01316
342109009103	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109009104	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
342109009105	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109009106	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109009107	catalytic residue [active]
342109009108	anthranilate synthase component I; Provisional; Region: PRK13565
342109009109	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
342109009110	chorismate binding enzyme; Region: Chorismate_bind; cl10555
342109009111	lipid kinase; Reviewed; Region: PRK13054
342109009112	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
342109009113	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
342109009114	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
342109009115	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
342109009116	substrate binding site [chemical binding]; other site
342109009117	hexamer interface [polypeptide binding]; other site
342109009118	metal binding site [ion binding]; metal-binding site
342109009119	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
342109009120	HSP70 interaction site [polypeptide binding]; other site
342109009121	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
342109009122	ATP binding site [chemical binding]; other site
342109009123	active site
342109009124	substrate binding site [chemical binding]; other site
342109009125	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009126	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009127	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009128	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109009129	Integrase core domain; Region: rve; cl01316
342109009130	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
342109009131	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
342109009132	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
342109009133	active site
342109009134	Zn binding site [ion binding]; other site
342109009135	Protein of unknown function (DUF962); Region: DUF962; cl01879
342109009136	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
342109009137	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
342109009138	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
342109009139	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
342109009140	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
342109009141	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
342109009142	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
342109009143	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
342109009144	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
342109009145	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
342109009146	homogentisate 1,2-dioxygenase; Region: HgmA; cl10473
342109009147	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
342109009148	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
342109009149	dimer interface [polypeptide binding]; other site
342109009150	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
342109009151	active site
342109009152	Fe binding site [ion binding]; other site
342109009153	Transcriptional regulators [Transcription]; Region: MarR; COG1846
342109009154	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109009155	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
342109009156	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
342109009157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
342109009158	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
342109009159	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
342109009160	Calx-beta domain; Region: Calx-beta; cl02522
342109009161	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
342109009162	tetramer interface [polypeptide binding]; other site
342109009163	TPP-binding site [chemical binding]; other site
342109009164	heterodimer interface [polypeptide binding]; other site
342109009165	phosphorylation loop region [posttranslational modification]
342109009166	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
342109009167	alpha subunit interface [polypeptide binding]; other site
342109009168	TPP binding site [chemical binding]; other site
342109009169	heterodimer interface [polypeptide binding]; other site
342109009170	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109009171	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109009172	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
342109009173	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
342109009174	Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization...; Region: SH3; cl09950
342109009175	Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization...; Region: SH3; cl09950
342109009176	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
342109009177	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
342109009178	dimer interface [polypeptide binding]; other site
342109009179	active site
342109009180	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
342109009181	HemY protein N-terminus; Region: HemY_N; pfam07219
342109009182	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578
342109009183	active site
342109009184	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
342109009185	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
342109009186	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009187	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009188	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009189	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109009190	Transposase domain (DUF772); Region: DUF772; cl12084
342109009191	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109009192	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
342109009193	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
342109009194	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051
342109009195	Ca2+ binding site [ion binding]; other site
342109009196	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
342109009197	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
342109009198	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
342109009199	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
342109009200	amidase catalytic site [active]
342109009201	Zn binding residues [ion binding]; other site
342109009202	substrate binding site [chemical binding]; other site
342109009203	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
342109009204	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
342109009205	NlpC/P60 family; Region: NLPC_P60; cl11438
342109009206	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
342109009207	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319
342109009208	active site
342109009209	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009210	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009211	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009212	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009213	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009214	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009215	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109009216	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109009217	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009218	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009219	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
342109009220	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
342109009221	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109009222	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109009223	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109009224	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109009225	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009226	hypothetical protein; Provisional; Region: PRK11383
342109009227	yiaA/B two helix domain; Region: YiaAB; cl01759
342109009228	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
342109009229	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
342109009230	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109009231	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109009232	Integrase core domain; Region: rve; cl01316
342109009233	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109009234	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109009235	Integrase core domain; Region: rve; cl01316
342109009236	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
342109009237	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
342109009238	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
342109009239	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534
342109009240	homooctamer interface [polypeptide binding]; other site
342109009241	active site
342109009242	UGMP family protein; Validated; Region: PRK09604
342109009243	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
342109009244	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
342109009245	GatB domain; Region: GatB_Yqey; cl11497
342109009246	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
342109009247	DNA primase; Validated; Region: dnaG; PRK05667
342109009248	CHC2 zinc finger; Region: zf-CHC2; cl02597
342109009249	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
342109009250	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
342109009251	active site
342109009252	metal binding site [ion binding]; metal-binding site
342109009253	interdomain interaction site; other site
342109009254	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
342109009255	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
342109009256	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109009257	Membrane transport protein; Region: Mem_trans; cl09117
342109009258	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
342109009259	catalytic residues [active]
342109009260	UbiA prenyltransferase family; Region: UbiA; cl00337
342109009261	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
342109009262	cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127
342109009263	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
342109009264	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
342109009265	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
342109009266	Subunit III/VIIa interface [polypeptide binding]; other site
342109009267	Phospholipid binding site [chemical binding]; other site
342109009268	Subunit I/III interface [polypeptide binding]; other site
342109009269	Subunit III/VIb interface [polypeptide binding]; other site
342109009270	Subunit III/VIa interface; other site
342109009271	Subunit III/Vb interface [polypeptide binding]; other site
342109009272	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240
342109009273	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
342109009274	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
342109009275	Subunit I/III interface [polypeptide binding]; other site
342109009276	D-pathway; other site
342109009277	Subunit I/VIIc interface [polypeptide binding]; other site
342109009278	Subunit I/IV interface [polypeptide binding]; other site
342109009279	Subunit I/II interface [polypeptide binding]; other site
342109009280	Low-spin heme (heme a) binding site [chemical binding]; other site
342109009281	Subunit I/VIIa interface [polypeptide binding]; other site
342109009282	Subunit I/VIa interface [polypeptide binding]; other site
342109009283	Dimer interface; other site
342109009284	Putative water exit pathway; other site
342109009285	Binuclear center (heme a3/CuB) [ion binding]; other site
342109009286	K-pathway; other site
342109009287	Subunit I/Vb interface [polypeptide binding]; other site
342109009288	Putative proton exit pathway; other site
342109009289	Subunit I/VIb interface; other site
342109009290	Subunit I/VIc interface [polypeptide binding]; other site
342109009291	Electron transfer pathway; other site
342109009292	Subunit I/VIIIb interface [polypeptide binding]; other site
342109009293	Subunit I/VIIb interface [polypeptide binding]; other site
342109009294	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
342109009295	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
342109009296	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
342109009297	Integral membrane protein (DUF2244); Region: DUF2244; cl02302
342109009298	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
342109009299	Proline dehydrogenase; Region: Pro_dh; cl03282
342109009300	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
342109009301	Glutamate binding site [chemical binding]; other site
342109009302	NAD binding site [chemical binding]; other site
342109009303	catalytic residues [active]
342109009304	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109009305	Integrase core domain; Region: rve; cl01316
342109009306	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109009307	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109009308	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
342109009309	Ferritin-like domain; Region: Ferritin; pfam00210
342109009310	heme binding site [chemical binding]; other site
342109009311	ferroxidase pore; other site
342109009312	ferroxidase diiron center [ion binding]; other site
342109009313	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671
342109009314	putative active site [active]
342109009315	Ap4A binding site [chemical binding]; other site
342109009316	nudix motif; other site
342109009317	putative metal binding site [ion binding]; other site
342109009318	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
342109009319	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
342109009320	23S rRNA interface [nucleotide binding]; other site
342109009321	L3 interface [polypeptide binding]; other site
342109009322	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
342109009323	diiron binding motif [ion binding]; other site
342109009324	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
342109009325	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
342109009326	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
342109009327	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
342109009328	ligand binding site [chemical binding]; other site
342109009329	flexible hinge region; other site
342109009330	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109009331	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
342109009332	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
342109009333	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
342109009334	active site
342109009335	ribulose/triose binding site [chemical binding]; other site
342109009336	phosphate binding site [ion binding]; other site
342109009337	substrate (anthranilate) binding pocket [chemical binding]; other site
342109009338	product (indole) binding pocket [chemical binding]; other site
342109009339	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
342109009340	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
342109009341	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
342109009342	Flavin Reductases; Region: FlaRed; cl00801
342109009343	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
342109009344	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
342109009345	glutamine binding [chemical binding]; other site
342109009346	catalytic triad [active]
342109009347	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
342109009348	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109009349	putative transposase OrfB; Reviewed; Region: PHA02517
342109009350	Integrase core domain; Region: rve; cl01316
342109009351	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109009352	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
342109009353	Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971
342109009354	Uncharacterized conserved protein [Function unknown]; Region: COG4715
342109009355	Uncharacterized conserved protein [Function unknown]; Region: COG4715
342109009356	Transposase domain (DUF772); Region: DUF772; cl12084
342109009357	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009358	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009359	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109009360	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109009361	Transposase domain (DUF772); Region: DUF772; cl12084
342109009362	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109009363	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109009364	Integrase core domain; Region: rve; cl01316
342109009365	Transposase, Mutator family; Region: Transposase_mut; pfam00872
342109009366	MULE transposase domain; Region: MULE; pfam10551
342109009367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
342109009368	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
342109009369	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
342109009370	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009371	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009372	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
342109009373	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
342109009374	metal binding site [ion binding]; metal-binding site
342109009375	putative dimer interface [polypeptide binding]; other site
342109009376	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
342109009377	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
342109009378	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
342109009379	Protein export membrane protein; Region: SecD_SecF; cl14618
342109009380	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
342109009381	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
342109009382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009383	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109009384	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109009385	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
342109009386	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
342109009387	active site residue [active]
342109009388	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
342109009389	SecA binding site; other site
342109009390	Preprotein binding site; other site
342109009391	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
342109009392	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109009393	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
342109009394	pyruvate dehydrogenase; Provisional; Region: PRK09124
342109009395	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
342109009396	PYR/PP interface [polypeptide binding]; other site
342109009397	tetramer interface [polypeptide binding]; other site
342109009398	dimer interface [polypeptide binding]; other site
342109009399	TPP binding site [chemical binding]; other site
342109009400	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
342109009401	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014
342109009402	TPP-binding site [chemical binding]; other site
342109009403	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
342109009404	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
342109009405	dimer interface [polypeptide binding]; other site
342109009406	phosphorylation site [posttranslational modification]
342109009407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109009408	ATP binding site [chemical binding]; other site
342109009409	Mg2+ binding site [ion binding]; other site
342109009410	G-X-G motif; other site
342109009411	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
342109009412	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109009413	active site
342109009414	phosphorylation site [posttranslational modification]
342109009415	intermolecular recognition site; other site
342109009416	dimerization interface [polypeptide binding]; other site
342109009417	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109009418	Walker A motif; other site
342109009419	ATP binding site [chemical binding]; other site
342109009420	Walker B motif; other site
342109009421	arginine finger; other site
342109009422	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
342109009423	conjugal transfer protein TrbE; Provisional; Region: PRK13891
342109009424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109009425	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
342109009426	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
342109009427	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
342109009428	dimer interface [polypeptide binding]; other site
342109009429	active site
342109009430	CoA binding pocket [chemical binding]; other site
342109009431	Fic family protein [Function unknown]; Region: COG3177
342109009432	Fic/DOC family; Region: Fic; cl00960
342109009433	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109009434	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109009435	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
342109009436	haloalkane dehalogenase; Provisional; Region: PRK03592
342109009437	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109009438	Flagellin N-methylase; Region: FliB; cl00497
342109009439	peptide synthase; Provisional; Region: PRK09274
342109009440	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
342109009441	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109009442	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
342109009443	NAD(P) binding site [chemical binding]; other site
342109009444	active site
342109009445	Transposase domain (DUF772); Region: DUF772; cl12084
342109009446	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
342109009447	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
342109009448	Zn2+ binding site [ion binding]; other site
342109009449	Mg2+ binding site [ion binding]; other site
342109009450	benzoate transport; Region: 2A0115; TIGR00895
342109009451	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109009452	putative substrate translocation pore; other site
342109009453	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109009454	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109009455	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009456	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109009457	Integrase core domain; Region: rve; cl01316
342109009458	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
342109009459	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
342109009460	trimer interface [polypeptide binding]; other site
342109009461	putative metal binding site [ion binding]; other site
342109009462	Dehydratase family; Region: ILVD_EDD; cl00340
342109009463	dihydroxy-acid dehydratase; Region: ilvD; TIGR00110
342109009464	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
342109009465	Phage integrase family; Region: Phage_integrase; pfam00589
342109009466	DNA binding site [nucleotide binding]
342109009467	Int/Topo IB signature motif; other site
342109009468	active site
342109009469	Transposase domain (DUF772); Region: DUF772; cl12084
342109009470	Transposase domain (DUF772); Region: DUF772; cl12084
342109009471	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109009472	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109009473	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
342109009474	DNA polymerase I; Provisional; Region: PRK05755
342109009475	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
342109009476	active site
342109009477	metal binding site 1 [ion binding]; metal-binding site
342109009478	putative 5' ssDNA interaction site; other site
342109009479	metal binding site 3; metal-binding site
342109009480	metal binding site 2 [ion binding]; metal-binding site
342109009481	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
342109009482	putative DNA binding site [nucleotide binding]; other site
342109009483	putative metal binding site [ion binding]; other site
342109009484	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
342109009485	active site
342109009486	catalytic site [active]
342109009487	substrate binding site [chemical binding]; other site
342109009488	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
342109009489	active site
342109009490	DNA binding site [nucleotide binding]
342109009491	catalytic site [active]
342109009492	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
342109009493	putative transposase OrfB; Reviewed; Region: PHA02517
342109009494	Integrase core domain; Region: rve; cl01316
342109009495	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109009496	HIRAN domain; Region: HIRAN; pfam08797
342109009497	HipA-like C-terminal domain; Region: HipA_C; pfam07804
342109009498	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
342109009499	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
342109009500	dimer interface [polypeptide binding]; other site
342109009501	TPP-binding site [chemical binding]; other site
342109009502	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
342109009503	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
342109009504	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
342109009505	nucleophilic elbow; other site
342109009506	catalytic triad; other site
342109009507	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109009508	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109009509	Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377
342109009510	Transposase domain (DUF772); Region: DUF772; cl12084
342109009511	putative transposase OrfB; Reviewed; Region: PHA02517
342109009512	Cache domain; Region: Cache_1; pfam02743
342109009513	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
342109009514	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
342109009515	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
342109009516	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
342109009517	anti sigma factor interaction site; other site
342109009518	regulatory phosphorylation site [posttranslational modification]; other site
342109009519	YceI-like domain; Region: YceI; cl01001
342109009520	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
342109009521	putative FMN binding site [chemical binding]; other site
342109009522	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
342109009523	Protein of unknown function (DUF1022); Region: DUF1022; pfam06258
342109009524	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
342109009525	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
342109009526	catalytic residues [active]
342109009527	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
342109009528	catalytic residues [active]
342109009529	Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; pfam09286
342109009530	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
342109009531	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
342109009532	metal binding triad; other site
342109009533	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
342109009534	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
342109009535	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
342109009536	metal binding triad; other site
342109009537	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
342109009538	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109009539	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109009540	NeuB family; Region: NeuB; cl00496
342109009541	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
342109009542	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109009543	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109009544	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
342109009545	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
342109009546	ring oligomerisation interface [polypeptide binding]; other site
342109009547	ATP/Mg binding site [chemical binding]; other site
342109009548	stacking interactions; other site
342109009549	hinge regions; other site
342109009550	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320
342109009551	oligomerisation interface [polypeptide binding]; other site
342109009552	mobile loop; other site
342109009553	roof hairpin; other site
342109009554	LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167
342109009555	putative metal binding site [ion binding]; other site
342109009556	LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7; Region: LOTUS; cl14879
342109009557	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
342109009558	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109009559	UPF0126 domain; Region: UPF0126; pfam03458
342109009560	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
342109009561	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
342109009562	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
342109009563	DNA binding residues [nucleotide binding]
342109009564	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
342109009565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109009566	active site
342109009567	phosphorylation site [posttranslational modification]
342109009568	intermolecular recognition site; other site
342109009569	dimerization interface [polypeptide binding]; other site
342109009570	Response regulator receiver domain; Region: Response_reg; pfam00072
342109009571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109009572	active site
342109009573	phosphorylation site [posttranslational modification]
342109009574	intermolecular recognition site; other site
342109009575	dimerization interface [polypeptide binding]; other site
342109009576	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
342109009577	FtsX-like permease family; Region: FtsX; pfam02687
342109009578	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
342109009579	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109009580	Walker A/P-loop; other site
342109009581	ATP binding site [chemical binding]; other site
342109009582	Q-loop/lid; other site
342109009583	ABC transporter signature motif; other site
342109009584	Walker B; other site
342109009585	D-loop; other site
342109009586	H-loop/switch region; other site
342109009587	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04537
342109009588	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
342109009589	ATP binding site [chemical binding]; other site
342109009590	Mg++ binding site [ion binding]; other site
342109009591	motif III; other site
342109009592	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109009593	nucleotide binding region [chemical binding]; other site
342109009594	ATP-binding site [chemical binding]; other site
342109009595	Protein of unknown function (DUF3628); Region: DUF3628; pfam12300
342109009596	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
342109009597	catalytic residues [active]
342109009598	transcription termination factor Rho; Provisional; Region: rho; PRK09376
342109009599	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
342109009600	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459
342109009601	RNA binding site [nucleotide binding]; other site
342109009602	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128
342109009603	multimer interface [polypeptide binding]; other site
342109009604	Walker A motif; other site
342109009605	ATP binding site [chemical binding]; other site
342109009606	Walker B motif; other site
342109009607	Integrase core domain; Region: rve; cl01316
342109009608	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
342109009609	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
342109009610	Surface antigen; Region: Bac_surface_Ag; cl03097
342109009611	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
342109009612	Family of unknown function (DUF490); Region: DUF490; pfam04357
342109009613	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109009614	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
342109009615	putative active site 1 [active]
342109009616	Predicted exporter [General function prediction only]; Region: COG4258
342109009617	Predicted acyltransferase [General function prediction only]; Region: COG4261
342109009618	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
342109009619	putative acyl-acceptor binding pocket; other site
342109009620	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
342109009621	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
342109009622	putative acyl-acceptor binding pocket; other site
342109009623	Phosphopantetheine attachment site; Region: PP-binding; cl09936
342109009624	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
342109009625	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109009626	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.   The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153
342109009627	homotrimer interaction site [polypeptide binding]; other site
342109009628	putative active site [active]
342109009629	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
342109009630	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
342109009631	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
342109009632	translocation protein TolB; Provisional; Region: tolB; PRK04922
342109009633	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
342109009634	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109009635	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
342109009636	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109009637	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
342109009638	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
342109009639	NADP binding site [chemical binding]; other site
342109009640	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
342109009641	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
342109009642	2-keto-3-deoxygluconate permease; Region: KdgT; cl14653
342109009643	C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311
342109009644	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Provisional; Region: PRK08575
342109009645	substrate binding site [chemical binding]; other site
342109009646	THF binding site; other site
342109009647	zinc-binding site [ion binding]; other site
342109009648	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
342109009649	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
342109009650	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
342109009651	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109009652	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
342109009653	putative dimerization interface [polypeptide binding]; other site
342109009654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
342109009655	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
342109009656	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537
342109009657	FAD binding site [chemical binding]; other site
342109009658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109009659	ATP binding site [chemical binding]; other site
342109009660	Mg2+ binding site [ion binding]; other site
342109009661	G-X-G motif; other site
342109009662	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
342109009663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109009664	active site
342109009665	phosphorylation site [posttranslational modification]
342109009666	intermolecular recognition site; other site
342109009667	dimerization interface [polypeptide binding]; other site
342109009668	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
342109009669	DNA binding site [nucleotide binding]
342109009670	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
342109009671	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
342109009672	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
342109009673	putative substrate binding site [chemical binding]; other site
342109009674	putative active site [active]
342109009675	putative cosubstrate binding site; other site
342109009676	catalytic site [active]
342109009677	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
342109009678	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109009679	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
342109009680	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
342109009681	active site
342109009682	FMN binding site [chemical binding]; other site
342109009683	substrate binding site [chemical binding]; other site
342109009684	homotetramer interface [polypeptide binding]; other site
342109009685	catalytic residue [active]
342109009686	NAD-dependent deacetylase; Provisional; Region: PRK05333
342109009687	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/...; Region: SIRT4; cd01409
342109009688	NAD+ binding site [chemical binding]; other site
342109009689	substrate binding site [chemical binding]; other site
342109009690	Zn binding site [ion binding]; other site
342109009691	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
342109009692	DNA binding residues [nucleotide binding]
342109009693	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109009694	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
342109009695	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109009696	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
342109009697	putative dimerization interface [polypeptide binding]; other site
342109009698	putative substrate binding pocket [chemical binding]; other site
342109009699	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
342109009700	active site
342109009701	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
342109009702	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
342109009703	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109009704	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
342109009705	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109009706	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109009707	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109009708	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009709	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
342109009710	Integrase core domain; Region: rve; cl01316
342109009711	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
342109009712	active site
342109009713	metal binding site [ion binding]; metal-binding site
342109009714	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109009715	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109009716	catalytic residue [active]
342109009717	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
342109009718	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
342109009719	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
342109009720	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
342109009721	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
342109009722	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
342109009723	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822
342109009724	active site
342109009725	homotetramer interface [polypeptide binding]; other site
342109009726	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109009727	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009728	Integrase core domain; Region: rve; cl01316
342109009729	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009730	Integrase core domain; Region: rve; cl01316
342109009731	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
342109009732	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109009733	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
342109009734	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
342109009735	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
342109009736	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
342109009737	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
342109009738	carboxyltransferase (CT) interaction site; other site
342109009739	biotinylation site [posttranslational modification]; other site
342109009740	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
342109009741	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
342109009742	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
342109009743	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
342109009744	isovaleryl-CoA dehydrogenase; Region: PLN02519
342109009745	substrate binding site [chemical binding]; other site
342109009746	FAD binding site [chemical binding]; other site
342109009747	catalytic base [active]
342109009748	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
342109009749	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342109009750	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
342109009751	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
342109009752	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
342109009753	Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670
342109009754	Cytochrome c; Region: Cytochrom_C; cl11414
342109009755	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
342109009756	generic binding surface I; other site
342109009757	generic binding surface II; other site
342109009758	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
342109009759	putative catalytic site [active]
342109009760	putative metal binding site [ion binding]; other site
342109009761	putative phosphate binding site [ion binding]; other site
342109009762	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
342109009763	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
342109009764	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
342109009765	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
342109009766	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
342109009767	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
342109009768	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
342109009769	Predicted ATPase [General function prediction only]; Region: COG1485
342109009770	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109009771	Walker A/P-loop; other site
342109009772	ATP binding site [chemical binding]; other site
342109009773	Q-loop/lid; other site
342109009774	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109009775	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109009776	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
342109009777	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
342109009778	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
342109009779	glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388
342109009780	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
342109009781	dimer interface [polypeptide binding]; other site
342109009782	motif 1; other site
342109009783	active site
342109009784	motif 2; other site
342109009785	motif 3; other site
342109009786	GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
342109009787	general secretory pathway protein E; Region: type_II_gspE; TIGR02533
342109009788	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
342109009789	Walker A motif; other site
342109009790	ATP binding site [chemical binding]; other site
342109009791	Walker B motif; other site
342109009792	hypothetical protein; Provisional; Region: PRK14707
342109009793	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
342109009794	synthetase active site [active]
342109009795	NTP binding site [chemical binding]; other site
342109009796	metal binding site [ion binding]; metal-binding site
342109009797	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009798	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009799	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009800	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
342109009801	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
342109009802	catalytic triad [active]
342109009803	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
342109009804	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
342109009805	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
342109009806	Family of unknown function (DUF500); Region: DUF500; cl01109
342109009807	ferrochelatase; Reviewed; Region: hemH; PRK00035
342109009808	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
342109009809	C-terminal domain interface [polypeptide binding]; other site
342109009810	active site
342109009811	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
342109009812	active site
342109009813	N-terminal domain interface [polypeptide binding]; other site
342109009814	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
342109009815	Protein of unknown function DUF45; Region: DUF45; cl00636
342109009816	Putative exonuclease, RdgC; Region: RdgC; cl01122
342109009817	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
342109009818	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This...; Region: Alpha_ANH_like_II; cd01993
342109009819	Ligand Binding Site [chemical binding]; other site
342109009820	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
342109009821	xylose isomerase; Region: PLN02923
342109009822	Transcriptional regulators [Transcription]; Region: PurR; COG1609
342109009823	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
342109009824	DNA binding site [nucleotide binding]
342109009825	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
342109009826	putative dimerization interface [polypeptide binding]; other site
342109009827	putative ligand binding site [chemical binding]; other site
342109009828	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
342109009829	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
342109009830	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
342109009831	Domain of unknown function (DUF303); Region: DUF303; pfam03629
342109009832	Domain of unknown function (DUF303); Region: DUF303; pfam03629
342109009833	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
342109009834	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
342109009835	putative active site pocket [active]
342109009836	putative metal binding site [ion binding]; other site
342109009837	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
342109009838	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
342109009839	inhibitor binding site; inhibition site
342109009840	active site
342109009841	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
342109009842	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
342109009843	PA14 domain; Region: PA14; cl08459
342109009844	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
342109009845	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
342109009846	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
342109009847	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
342109009848	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
342109009849	metal binding site [ion binding]; metal-binding site
342109009850	Glucuronate isomerase; Region: UxaC; cl00829
342109009851	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
342109009852	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
342109009853	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
342109009854	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109009855	D-galactonate transporter; Region: 2A0114; TIGR00893
342109009856	putative substrate translocation pore; other site
342109009857	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
342109009858	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109009859	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109009860	putative transporter; Provisional; Region: PRK11462
342109009861	putative symporter YagG; Provisional; Region: PRK09669
342109009862	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
342109009863	substrate binding site [chemical binding]; other site
342109009864	active site
342109009865	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009866	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009867	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009868	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
342109009869	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
342109009870	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109009871	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109009872	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
342109009873	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009874	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
342109009875	Fatty acid desaturase; Region: FA_desaturase; pfam00487
342109009876	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506
342109009877	putative di-iron ligands [ion binding]; other site
342109009878	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
342109009879	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
342109009880	FAD binding pocket [chemical binding]; other site
342109009881	FAD binding motif [chemical binding]; other site
342109009882	phosphate binding motif [ion binding]; other site
342109009883	beta-alpha-beta structure motif; other site
342109009884	NAD binding pocket [chemical binding]; other site
342109009885	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
342109009886	catalytic loop [active]
342109009887	iron binding site [ion binding]; other site
342109009888	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
342109009889	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
342109009890	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009891	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009892	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109009893	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109009894	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
342109009895	Integrase core domain; Region: rve; cl01316
342109009896	Protein of unknown function (DUF3182); Region: DUF3182; pfam11379
342109009897	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109009898	OsmC-like protein; Region: OsmC; cl00767
342109009899	Protein of unknown function (DUF2884); Region: DUF2884; cl08135
342109009900	Transposase domain (DUF772); Region: DUF772; cl12084
342109009901	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009902	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
342109009903	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
342109009904	Uncharacterized conserved protein [Function unknown]; Region: COG4104
342109009905	DUF based on B. Theta Gene description; Region: DUF3876; pfam12992
342109009906	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
342109009907	active site
342109009908	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342109009909	non-specific DNA binding site [nucleotide binding]; other site
342109009910	salt bridge; other site
342109009911	sequence-specific DNA binding site [nucleotide binding]; other site
342109009912	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
342109009913	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
342109009914	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
342109009915	UvrD/REP helicase; Region: UvrD-helicase; cl14126
342109009916	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
342109009917	UvrD/REP helicase; Region: UvrD-helicase; cl14126
342109009918	UvrD/REP helicase; Region: UvrD-helicase; cl14126
342109009919	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
342109009920	UvrD/REP helicase; Region: UvrD-helicase; cl14126
342109009921	UvrD/REP helicase; Region: UvrD-helicase; cl14126
342109009922	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
342109009923	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
342109009924	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
342109009925	PHP domain; Region: PHP; pfam02811
342109009926	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
342109009927	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109009928	ABC transporter signature motif; other site
342109009929	Walker B; other site
342109009930	D-loop; other site
342109009931	H-loop/switch region; other site
342109009932	Putative Ig domain; Region: He_PIG; cl09256
342109009933	Autotransporter beta-domain; Region: Autotransporter; cl02365
342109009934	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
342109009935	Phage Tail Collar Domain; Region: Collar; pfam07484
342109009936	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
342109009937	Phage Tail Collar Domain; Region: Collar; pfam07484
342109009938	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
342109009939	Phage Tail Collar Domain; Region: Collar; pfam07484
342109009940	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109009941	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109009942	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
342109009943	E-class dimer interface [polypeptide binding]; other site
342109009944	P-class dimer interface [polypeptide binding]; other site
342109009945	active site
342109009946	Cu2+ binding site [ion binding]; other site
342109009947	Zn2+ binding site [ion binding]; other site
342109009948	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
342109009949	P-class dimer interface [polypeptide binding]; other site
342109009950	active site
342109009951	Cu2+ binding site [ion binding]; other site
342109009952	E-class dimer interface [polypeptide binding]; other site
342109009953	Zn2+ binding site [ion binding]; other site
342109009954	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
342109009955	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109009956	active site
342109009957	phosphorylation site [posttranslational modification]
342109009958	intermolecular recognition site; other site
342109009959	dimerization interface [polypeptide binding]; other site
342109009960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
342109009961	Walker A motif; other site
342109009962	ATP binding site [chemical binding]; other site
342109009963	Walker B motif; other site
342109009964	arginine finger; other site
342109009965	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
342109009966	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
342109009967	ATP binding site [chemical binding]; other site
342109009968	Mg2+ binding site [ion binding]; other site
342109009969	G-X-G motif; other site
342109009970	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
342109009971	Nitrogen regulatory protein P-II; Region: P-II; cl00412
342109009972	glutamine synthetase; Provisional; Region: glnA; PRK09469
342109009973	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
342109009974	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
342109009975	Bacitracin resistance protein BacA; Region: BacA; cl00858
342109009976	META domain; Region: META; cl01245
342109009977	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
342109009978	putative NAD(P) binding site [chemical binding]; other site
342109009979	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
342109009980	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
342109009981	substrate binding site [chemical binding]; other site
342109009982	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
342109009983	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109009984	TPR motif; other site
342109009985	binding surface
342109009986	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109009987	binding surface
342109009988	TPR motif; other site
342109009989	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109009990	binding surface
342109009991	TPR motif; other site
342109009992	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
342109009993	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
342109009994	putative acyl-acceptor binding pocket; other site
342109009995	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
342109009996	CoenzymeA binding site [chemical binding]; other site
342109009997	subunit interaction site [polypeptide binding]; other site
342109009998	PHB binding site; other site
342109009999	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
342109010000	putative active site [active]
342109010001	catalytic site [active]
342109010002	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
342109010003	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
342109010004	putative active site [active]
342109010005	catalytic site [active]
342109010006	YceI-like domain; Region: YceI; cl01001
342109010007	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
342109010008	catalytic core [active]
342109010009	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
342109010010	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
342109010011	P-loop; other site
342109010012	Magnesium ion binding site [ion binding]; other site
342109010013	Membrane transport protein; Region: Mem_trans; cl09117
342109010014	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
342109010015	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
342109010016	dimer interface [polypeptide binding]; other site
342109010017	PYR/PP interface [polypeptide binding]; other site
342109010018	TPP binding site [chemical binding]; other site
342109010019	substrate binding site [chemical binding]; other site
342109010020	TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008
342109010021	TPP-binding site; other site
342109010022	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
342109010023	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
342109010024	non-specific DNA binding site [nucleotide binding]; other site
342109010025	salt bridge; other site
342109010026	sequence-specific DNA binding site [nucleotide binding]; other site
342109010027	HipA N-terminal domain; Region: couple_hipA; TIGR03071
342109010028	HipA-like N-terminal domain; Region: HipA_N; pfam07805
342109010029	HipA-like C-terminal domain; Region: HipA_C; pfam07804
342109010030	probable methyltransferase; Region: TIGR03438
342109010031	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
342109010032	TIGR03440 family protein; Region: unchr_TIGR03440
342109010033	DinB superfamily; Region: DinB_2; cl00986
342109010034	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
342109010035	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
342109010036	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
342109010037	catalytic residue [active]
342109010038	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109010039	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
342109010040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
342109010041	dimer interface [polypeptide binding]; other site
342109010042	conserved gate region; other site
342109010043	ABC-ATPase subunit interface; other site
342109010044	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109010045	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
342109010046	Walker A/P-loop; other site
342109010047	ATP binding site [chemical binding]; other site
342109010048	Q-loop/lid; other site
342109010049	ABC transporter signature motif; other site
342109010050	Walker B; other site
342109010051	D-loop; other site
342109010052	H-loop/switch region; other site
342109010053	Secreted protein acidic and rich in cysteine Ca binding region; Region: SPARC_Ca_bdg; pfam10591
342109010054	Fatty acid desaturase; Region: FA_desaturase; pfam00487
342109010055	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
342109010056	Di-iron ligands [ion binding]; other site
342109010057	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
342109010058	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
342109010059	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109010060	Walker A/P-loop; other site
342109010061	ATP binding site [chemical binding]; other site
342109010062	Q-loop/lid; other site
342109010063	ABC transporter signature motif; other site
342109010064	Walker B; other site
342109010065	D-loop; other site
342109010066	H-loop/switch region; other site
342109010067	Protein of unknown function DUF124; Region: DUF124; cl00884
342109010068	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
342109010069	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
342109010070	active site
342109010071	nucleophile elbow; other site
342109010072	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109010073	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109010074	Transposase domain (DUF772); Region: DUF772; cl12084
342109010075	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
342109010076	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
342109010077	Integrase core domain; Region: rve; cl01316
342109010078	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
342109010079	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
342109010080	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
342109010081	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
342109010082	active site
342109010083	catalytic tetrad [active]
342109010084	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
342109010085	Prostaglandin dehydrogenases; Region: PGDH; cd05288
342109010086	NAD(P) binding site [chemical binding]; other site
342109010087	substrate binding site [chemical binding]; other site
342109010088	dimer interface [polypeptide binding]; other site
342109010089	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
342109010090	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
342109010091	active site
342109010092	catalytic tetrad [active]
342109010093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109010094	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
342109010095	active site
342109010096	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
342109010097	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
342109010098	ATP binding site [chemical binding]; other site
342109010099	putative Mg++ binding site [ion binding]; other site
342109010100	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
342109010101	nucleotide binding region [chemical binding]; other site
342109010102	ATP-binding site [chemical binding]; other site
342109010103	Helicase associated domain (HA2); Region: HA2; cl04503
342109010104	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
342109010105	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
342109010106	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
342109010107	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
342109010108	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
342109010109	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
342109010110	putative active site pocket [active]
342109010111	metal binding site [ion binding]; metal-binding site
342109010112	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
342109010113	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
342109010114	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
342109010115	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
342109010116	NAD binding site [chemical binding]; other site
342109010117	homotetramer interface [polypeptide binding]; other site
342109010118	homodimer interface [polypeptide binding]; other site
342109010119	active site
342109010120	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
342109010121	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
342109010122	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
342109010123	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
342109010124	active site
342109010125	catalytic tetrad [active]
342109010126	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
342109010127	Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616
342109010128	active site
342109010129	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
342109010130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
342109010131	active site
342109010132	phosphorylation site [posttranslational modification]
342109010133	intermolecular recognition site; other site
342109010134	dimerization interface [polypeptide binding]; other site
342109010135	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
342109010136	DNA binding residues [nucleotide binding]
342109010137	dimerization interface [polypeptide binding]; other site
342109010138	acetyl-CoA synthetase; Provisional; Region: PRK00174
342109010139	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
342109010140	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
342109010141	Protein of unknown function, DUF485; Region: DUF485; cl01231
342109010142	Sodium:solute symporter family; Region: SSF; cl00456
342109010143	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
342109010144	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
342109010145	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
342109010146	putative phosphate binding site [ion binding]; other site
342109010147	putative catalytic site [active]
342109010148	active site
342109010149	metal binding site A [ion binding]; metal-binding site
342109010150	DNA binding site [nucleotide binding]
342109010151	putative AP binding site [nucleotide binding]; other site
342109010152	putative metal binding site B [ion binding]; other site
342109010153	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
342109010154	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
342109010155	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
342109010156	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
342109010157	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
342109010158	putative active site [active]
342109010159	putative metal binding site [ion binding]; other site
342109010160	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
342109010161	PhoD-like phosphatase; Region: PhoD; pfam09423
342109010162	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
342109010163	putative active site [active]
342109010164	putative metal binding site [ion binding]; other site
342109010165	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
342109010166	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
342109010167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
342109010168	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
342109010169	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
342109010170	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
342109010171	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
342109010172	Transposase; Region: DDE_Tnp_ISL3; pfam01610
342109010173	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
342109010174	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
342109010175	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
342109010176	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109010177	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
342109010178	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109010179	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
342109010180	dimerization interface [polypeptide binding]; other site
342109010181	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
342109010182	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
342109010183	putative active site [active]
342109010184	catalytic site [active]
342109010185	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
342109010186	putative active site [active]
342109010187	catalytic site [active]
342109010188	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
342109010189	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
342109010190	UvrD/REP helicase; Region: UvrD-helicase; cl14126
342109010191	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
342109010192	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
342109010193	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
342109010194	RmuC family; Region: RmuC; pfam02646
342109010195	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340
342109010196	catalytic residues [active]
342109010197	dimer interface [polypeptide binding]; other site
342109010198	Transposase domain (DUF772); Region: DUF772; cl12084
342109010199	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109010200	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
342109010201	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
342109010202	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
342109010203	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488
342109010204	Rhomboid family; Region: Rhomboid; cl11446
342109010205	Domain of unknown function (DUF1820); Region: DUF1820; cl11545
342109010206	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
342109010207	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
342109010208	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
342109010209	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
342109010210	protein binding site [polypeptide binding]; other site
342109010211	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
342109010212	Catalytic dyad [active]
342109010213	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
342109010214	Peptidase family M23; Region: Peptidase_M23; pfam01551
342109010215	Uncharacterized conserved protein [Function unknown]; Region: COG3595
342109010216	M28, and M42; Region: Zinc_peptidase_like; cl14876
342109010217	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-...; Region: PA_M28_1_2; cd04821
342109010218	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
342109010219	PA/protease or protease-like domain interface [polypeptide binding]; other site
342109010220	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
342109010221	metal binding site [ion binding]; metal-binding site
342109010222	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
342109010223	Transposase domain (DUF772); Region: DUF772; cl12084
342109010224	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
342109010225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
342109010226	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
342109010227	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
342109010228	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
342109010229	Predicted ATPase [General function prediction only]; Region: COG4637
342109010230	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
342109010231	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
342109010232	GTP cyclohydrolase I; Provisional; Region: PLN03044
342109010233	active site
342109010234	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
342109010235	Outer membrane efflux protein; Region: OEP; pfam02321
342109010236	Fusaric acid resistance protein family; Region: FUSC; pfam04632
342109010237	Fusaric acid resistance protein family; Region: FUSC; pfam04632
342109010238	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
342109010239	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109010240	putative substrate translocation pore; other site
342109010241	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
342109010242	putative active site [active]
342109010243	catalytic site [active]
342109010244	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
342109010245	Transposase domain (DUF772); Region: DUF772; cl12084
342109010246	Transposase domain (DUF772); Region: DUF772; cl12084
342109010247	Uncharacterized conserved protein [Function unknown]; Region: COG4104
342109010248	PAAR motif; Region: PAAR_motif; pfam05488
342109010249	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
342109010250	Glycerate kinase family; Region: Gly_kinase; cl00841
342109010251	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
342109010252	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
342109010253	putative substrate translocation pore; other site
342109010254	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301
342109010255	active site
342109010256	dimer interface [polypeptide binding]; other site
342109010257	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
342109010258	PUA domain; Region: PUA; cl00607
342109010259	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
342109010260	S-adenosylmethionine binding site [chemical binding]; other site
342109010261	Integral membrane protein TerC family; Region: TerC; cl10468
342109010262	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
342109010263	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
342109010264	putative active site [active]
342109010265	catalytic site [active]
342109010266	putative metal binding site [ion binding]; other site
342109010267	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109010268	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
342109010269	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role...; Region: PAP2_acid_phosphatase; cd03397
342109010270	active site
342109010271	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
342109010272	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
342109010273	TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes.  It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes.  TrmE contains a GTPase...; Region: trmE; cd04164
342109010274	G1 box; other site
342109010275	GTP/Mg2+ binding site [chemical binding]; other site
342109010276	Switch I region; other site
342109010277	G2 box; other site
342109010278	Switch II region; other site
342109010279	G3 box; other site
342109010280	G4 box; other site
342109010281	G5 box; other site
342109010282	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
342109010283	outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582
342109010284	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
342109010285	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
342109010286	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
342109010287	binding surface
342109010288	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
342109010289	TPR motif; other site
342109010290	membrane protein insertase; Provisional; Region: PRK01318
342109010291	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
342109010292	Ribonuclease P; Region: Ribonuclease_P; cl00457
342109010293	Ribosomal protein L34; Region: Ribosomal_L34; cl00370