-- dump date 20111121_015703 -- class Genbank::misc_feature -- table misc_feature_note -- id note 446471000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 446471000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471000003 Walker A motif; other site 446471000004 ATP binding site [chemical binding]; other site 446471000005 Walker B motif; other site 446471000006 arginine finger; other site 446471000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 446471000008 DnaA box-binding interface [nucleotide binding]; other site 446471000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 446471000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 446471000011 putative DNA binding surface [nucleotide binding]; other site 446471000012 dimer interface [polypeptide binding]; other site 446471000013 beta-clamp/clamp loader binding surface; other site 446471000014 beta-clamp/translesion DNA polymerase binding surface; other site 446471000015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 446471000017 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 446471000018 Walker A/P-loop; other site 446471000019 ATP binding site [chemical binding]; other site 446471000020 Q-loop/lid; other site 446471000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471000022 ABC transporter signature motif; other site 446471000023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471000024 Protein of unknown function (DUF721); Region: DUF721; cl02324 446471000025 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 446471000026 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 446471000027 anchoring element; other site 446471000028 dimer interface [polypeptide binding]; other site 446471000029 ATP binding site [chemical binding]; other site 446471000030 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 446471000031 active site 446471000032 putative metal-binding site [ion binding]; other site 446471000033 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446471000034 DNA gyrase subunit A; Validated; Region: PRK05560 446471000035 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 446471000036 CAP-like domain; other site 446471000037 active site 446471000038 primary dimer interface [polypeptide binding]; other site 446471000039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446471000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446471000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446471000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446471000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446471000044 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 446471000045 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 446471000046 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 446471000047 active site 446471000048 Rhomboid family; Region: Rhomboid; cl11446 446471000049 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 446471000050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 446471000051 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 446471000052 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 446471000053 active site 446471000054 catalytic site [active] 446471000055 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 446471000056 Glutamine amidotransferase class-I; Region: GATase; pfam00117 446471000057 glutamine binding [chemical binding]; other site 446471000058 catalytic triad [active] 446471000059 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446471000060 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446471000061 active site 446471000062 ATP binding site [chemical binding]; other site 446471000063 substrate binding site [chemical binding]; other site 446471000064 activation loop (A-loop); other site 446471000065 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446471000066 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446471000067 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446471000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446471000069 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446471000070 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446471000071 active site 446471000072 ATP binding site [chemical binding]; other site 446471000073 substrate binding site [chemical binding]; other site 446471000074 activation loop (A-loop); other site 446471000075 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 446471000076 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 446471000077 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446471000078 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 446471000079 active site 446471000080 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446471000081 phosphopeptide binding site; other site 446471000082 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 446471000083 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446471000084 phosphopeptide binding site; other site 446471000085 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 446471000086 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471000087 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471000088 Walker A/P-loop; other site 446471000089 ATP binding site [chemical binding]; other site 446471000090 Q-loop/lid; other site 446471000091 ABC transporter signature motif; other site 446471000092 Walker B; other site 446471000093 D-loop; other site 446471000094 H-loop/switch region; other site 446471000095 KduI/IolB family; Region: KduI; cl01508 446471000096 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446471000097 FtsX-like permease family; Region: FtsX; pfam02687 446471000098 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446471000099 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471000100 Protein of unknown function, DUF488; Region: DUF488; cl01246 446471000101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471000102 NAD(P) binding site [chemical binding]; other site 446471000103 active site 446471000104 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446471000105 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 446471000106 active site 446471000107 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446471000108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446471000109 Coenzyme A binding pocket [chemical binding]; other site 446471000110 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446471000111 Protein of unknown function (DUF1749); Region: DUF1749; pfam08538 446471000112 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 446471000113 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 446471000114 reactive center loop; other site 446471000115 aspartate aminotransferase; Provisional; Region: PRK05764 446471000116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446471000117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471000118 homodimer interface [polypeptide binding]; other site 446471000119 catalytic residue [active] 446471000120 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446471000121 putative metal binding site [ion binding]; other site 446471000122 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446471000123 putative phosphate binding site [ion binding]; other site 446471000124 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446471000125 putative catalytic site [active] 446471000126 putative phosphate binding site [ion binding]; other site 446471000127 putative metal binding site [ion binding]; other site 446471000128 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446471000129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471000130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471000131 dimerization interface [polypeptide binding]; other site 446471000132 glycine dehydrogenase; Provisional; Region: PRK05367 446471000133 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 446471000134 tetramer interface [polypeptide binding]; other site 446471000135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471000136 catalytic residue [active] 446471000137 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446471000138 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446471000139 catalytic residue [active] 446471000140 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 446471000141 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446471000142 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 446471000143 lipoyl attachment site [posttranslational modification]; other site 446471000144 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471000145 DNA binding residues [nucleotide binding] 446471000146 dimerization interface [polypeptide binding]; other site 446471000147 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 446471000148 active site 446471000149 8-oxo-dGMP binding site [chemical binding]; other site 446471000150 nudix motif; other site 446471000151 metal binding site [ion binding]; metal-binding site 446471000152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471000153 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 446471000154 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 446471000155 FAD binding site [chemical binding]; other site 446471000156 Uncharacterized conserved protein [Function unknown]; Region: COG1432 446471000157 LabA_like proteins; Region: LabA_like; cd06167 446471000158 putative metal binding site [ion binding]; other site 446471000159 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 446471000160 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 446471000161 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446471000162 putative acyl-acceptor binding pocket; other site 446471000163 Uncharacterized conserved protein [Function unknown]; Region: COG4850 446471000164 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 446471000165 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 446471000166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471000167 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446471000168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471000169 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446471000170 Walker A/P-loop; other site 446471000171 ATP binding site [chemical binding]; other site 446471000172 Q-loop/lid; other site 446471000173 ABC transporter signature motif; other site 446471000174 Walker B; other site 446471000175 D-loop; other site 446471000176 H-loop/switch region; other site 446471000177 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446471000178 Amino acid permease; Region: AA_permease; cl00524 446471000179 PspC domain; Region: PspC; cl00864 446471000180 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471000181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471000182 DNA binding site [nucleotide binding] 446471000183 domain linker motif; other site 446471000184 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446471000185 trehalose synthase; Region: treS_nterm; TIGR02456 446471000186 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471000187 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471000188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471000189 dimer interface [polypeptide binding]; other site 446471000190 conserved gate region; other site 446471000191 putative PBP binding loops; other site 446471000192 ABC-ATPase subunit interface; other site 446471000193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471000194 dimer interface [polypeptide binding]; other site 446471000195 conserved gate region; other site 446471000196 putative PBP binding loops; other site 446471000197 ABC-ATPase subunit interface; other site 446471000198 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 446471000199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471000200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471000201 dimerization interface [polypeptide binding]; other site 446471000202 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 446471000203 homotrimer interaction site [polypeptide binding]; other site 446471000204 putative active site [active] 446471000205 zeta-carotene desaturase; Region: PLN02487 446471000206 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 446471000207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471000208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471000209 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 446471000210 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 446471000211 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 446471000212 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446471000213 active site 446471000214 substrate binding site [chemical binding]; other site 446471000215 ATP binding site [chemical binding]; other site 446471000216 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 446471000217 putative ADP-ribose binding site [chemical binding]; other site 446471000218 putative active site [active] 446471000219 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 446471000220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471000221 ATP binding site [chemical binding]; other site 446471000222 putative Mg++ binding site [ion binding]; other site 446471000223 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471000224 Helicase associated domain (HA2); Region: HA2; cl04503 446471000225 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 446471000226 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 446471000227 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 446471000228 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 446471000229 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 446471000230 oligomeric interface; other site 446471000231 putative active site [active] 446471000232 homodimer interface [polypeptide binding]; other site 446471000233 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446471000234 GAF domain; Region: GAF; cl00853 446471000235 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446471000236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446471000237 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471000238 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471000239 DNA binding residues [nucleotide binding] 446471000240 dimerization interface [polypeptide binding]; other site 446471000241 hypothetical protein; Provisional; Region: PRK08185 446471000242 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 446471000243 intersubunit interface [polypeptide binding]; other site 446471000244 active site 446471000245 zinc binding site [ion binding]; other site 446471000246 Na+ binding site [ion binding]; other site 446471000247 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 446471000248 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 446471000249 DAK2 domain; Region: Dak2; cl03685 446471000250 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 446471000251 Dak1 domain; Region: Dak1; pfam02733 446471000252 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 446471000253 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 446471000254 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 446471000255 LamB/YcsF family; Region: LamB_YcsF; cl00664 446471000256 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 446471000257 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446471000258 anti sigma factor interaction site; other site 446471000259 regulatory phosphorylation site [posttranslational modification]; other site 446471000260 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446471000261 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446471000262 substrate binding pocket [chemical binding]; other site 446471000263 membrane-bound complex binding site; other site 446471000264 hinge residues; other site 446471000265 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446471000266 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446471000267 substrate binding pocket [chemical binding]; other site 446471000268 membrane-bound complex binding site; other site 446471000269 hinge residues; other site 446471000270 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 446471000271 Ligand Binding Site [chemical binding]; other site 446471000272 Molecular Tunnel; other site 446471000273 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471000274 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471000275 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471000276 Walker A/P-loop; other site 446471000277 ATP binding site [chemical binding]; other site 446471000278 Q-loop/lid; other site 446471000279 ABC transporter signature motif; other site 446471000280 Walker B; other site 446471000281 D-loop; other site 446471000282 H-loop/switch region; other site 446471000283 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471000284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471000285 active site 446471000286 phosphorylation site [posttranslational modification] 446471000287 intermolecular recognition site; other site 446471000288 dimerization interface [polypeptide binding]; other site 446471000289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471000290 DNA binding residues [nucleotide binding] 446471000291 dimerization interface [polypeptide binding]; other site 446471000292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446471000293 Histidine kinase; Region: HisKA_3; pfam07730 446471000294 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446471000295 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 446471000296 Walker A/P-loop; other site 446471000297 ATP binding site [chemical binding]; other site 446471000298 Q-loop/lid; other site 446471000299 ABC transporter signature motif; other site 446471000300 Walker B; other site 446471000301 D-loop; other site 446471000302 H-loop/switch region; other site 446471000303 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446471000304 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446471000305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471000306 dimer interface [polypeptide binding]; other site 446471000307 conserved gate region; other site 446471000308 putative PBP binding loops; other site 446471000309 ABC-ATPase subunit interface; other site 446471000310 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446471000311 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 446471000312 Walker A/P-loop; other site 446471000313 ATP binding site [chemical binding]; other site 446471000314 Q-loop/lid; other site 446471000315 ABC transporter signature motif; other site 446471000316 Walker B; other site 446471000317 D-loop; other site 446471000318 H-loop/switch region; other site 446471000319 conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319 446471000320 Excalibur calcium-binding domain; Region: Excalibur; cl05460 446471000321 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 446471000322 DNA-binding site [nucleotide binding]; DNA binding site 446471000323 RNA-binding motif; other site 446471000324 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 446471000325 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 446471000326 ligand binding site [chemical binding]; other site 446471000327 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446471000328 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 446471000329 Walker A/P-loop; other site 446471000330 ATP binding site [chemical binding]; other site 446471000331 Q-loop/lid; other site 446471000332 ABC transporter signature motif; other site 446471000333 Walker B; other site 446471000334 D-loop; other site 446471000335 H-loop/switch region; other site 446471000336 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446471000337 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 446471000338 Walker A/P-loop; other site 446471000339 ATP binding site [chemical binding]; other site 446471000340 Q-loop/lid; other site 446471000341 ABC transporter signature motif; other site 446471000342 Walker B; other site 446471000343 D-loop; other site 446471000344 H-loop/switch region; other site 446471000345 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 446471000346 TM-ABC transporter signature motif; other site 446471000347 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 446471000348 TM-ABC transporter signature motif; other site 446471000349 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 446471000350 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471000351 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446471000352 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 446471000353 putative hydrophobic ligand binding site [chemical binding]; other site 446471000354 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446471000355 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446471000356 catalytic residue [active] 446471000357 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471000358 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471000359 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446471000360 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 446471000361 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446471000362 catalytic core [active] 446471000363 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 446471000364 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 446471000365 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 446471000366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471000367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446471000368 putative substrate translocation pore; other site 446471000369 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471000370 NlpC/P60 family; Region: NLPC_P60; cl11438 446471000371 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 446471000372 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 446471000373 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 446471000374 dimer interface [polypeptide binding]; other site 446471000375 ligand binding site [chemical binding]; other site 446471000376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471000377 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 446471000378 active site 446471000379 NTP binding site [chemical binding]; other site 446471000380 metal binding triad [ion binding]; metal-binding site 446471000381 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 446471000382 Domain of unknown function (DUF336); Region: DUF336; cl01249 446471000383 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471000384 DNA binding residues [nucleotide binding] 446471000385 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 446471000386 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 446471000387 Excalibur calcium-binding domain; Region: Excalibur; cl05460 446471000388 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446471000389 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471000390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471000391 active site 446471000392 phosphorylation site [posttranslational modification] 446471000393 intermolecular recognition site; other site 446471000394 dimerization interface [polypeptide binding]; other site 446471000395 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471000396 DNA binding residues [nucleotide binding] 446471000397 dimerization interface [polypeptide binding]; other site 446471000398 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446471000399 active site 446471000400 metal binding site [ion binding]; metal-binding site 446471000401 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446471000402 Amino acid permease; Region: AA_permease; cl00524 446471000403 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446471000404 Permease family; Region: Xan_ur_permease; cl00967 446471000405 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 446471000406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471000407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471000408 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446471000409 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446471000410 Walker A/P-loop; other site 446471000411 ATP binding site [chemical binding]; other site 446471000412 Q-loop/lid; other site 446471000413 ABC transporter signature motif; other site 446471000414 Walker B; other site 446471000415 D-loop; other site 446471000416 H-loop/switch region; other site 446471000417 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446471000418 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446471000419 metal ion-dependent adhesion site (MIDAS); other site 446471000420 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 446471000421 T surface-antigen of pili; Region: FctA; pfam12892 446471000422 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 446471000423 T surface-antigen of pili; Region: FctA; pfam12892 446471000424 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 446471000425 T surface-antigen of pili; Region: FctA; pfam12892 446471000426 Domain of unknown function DUF11; Region: DUF11; cl15273 446471000427 Domain of unknown function DUF11; Region: DUF11; cl15273 446471000428 T surface-antigen of pili; Region: FctA; pfam12892 446471000429 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 446471000430 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446471000431 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 446471000432 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446471000433 FeS/SAM binding site; other site 446471000434 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 446471000435 oligomeric interface; other site 446471000436 putative active site [active] 446471000437 homodimer interface [polypeptide binding]; other site 446471000438 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 446471000439 Bacterial membrane flanked domain; Region: DUF304; cl01348 446471000440 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446471000441 catalytic core [active] 446471000442 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 446471000443 Fatty acid desaturase; Region: FA_desaturase; pfam00487 446471000444 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 446471000445 putative di-iron ligands [ion binding]; other site 446471000446 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 446471000447 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 446471000448 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446471000449 minor groove reading motif; other site 446471000450 helix-hairpin-helix signature motif; other site 446471000451 active site 446471000452 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 446471000453 RNA/DNA hybrid binding site [nucleotide binding]; other site 446471000454 active site 446471000455 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 446471000456 diiron binding motif [ion binding]; other site 446471000457 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 446471000458 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 446471000459 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 446471000460 ATP-binding site [chemical binding]; other site 446471000461 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471000462 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471000463 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 446471000464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471000465 domain; Region: Succ_DH_flav_C; pfam02910 446471000466 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 446471000467 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 446471000468 phosphoglucomutase; Validated; Region: PRK07564 446471000469 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 446471000470 active site 446471000471 substrate binding site [chemical binding]; other site 446471000472 metal binding site [ion binding]; metal-binding site 446471000473 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 446471000474 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 446471000475 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 446471000476 NAD(P) binding site [chemical binding]; other site 446471000477 Nitrate and nitrite sensing; Region: NIT; pfam08376 446471000478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446471000479 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 446471000480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471000481 ATP binding site [chemical binding]; other site 446471000482 G-X-G motif; other site 446471000483 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 446471000484 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446471000485 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446471000486 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cd00882 446471000487 G1 box; other site 446471000488 GTP/Mg2+ binding site [chemical binding]; other site 446471000489 G2 box; other site 446471000490 Switch I region; other site 446471000491 G3 box; other site 446471000492 Switch II region; other site 446471000493 Uncharacterized conserved protein [Function unknown]; Region: COG2966 446471000494 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 446471000495 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 446471000496 Domain of unknown function (DUF385); Region: DUF385; cl04387 446471000497 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 446471000498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471000499 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 446471000500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446471000501 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446471000502 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471000503 Walker A/P-loop; other site 446471000504 ATP binding site [chemical binding]; other site 446471000505 Q-loop/lid; other site 446471000506 ABC transporter signature motif; other site 446471000507 Walker B; other site 446471000508 D-loop; other site 446471000509 H-loop/switch region; other site 446471000510 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 446471000511 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 446471000512 Domain of unknown function; Region: DUF291; pfam03442 446471000513 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 446471000514 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 446471000515 active site 446471000516 dimer interface [polypeptide binding]; other site 446471000517 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 446471000518 dimer interface [polypeptide binding]; other site 446471000519 active site 446471000520 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471000521 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471000522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471000523 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471000524 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471000525 DNA binding site [nucleotide binding] 446471000526 domain linker motif; other site 446471000527 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446471000528 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 446471000529 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446471000530 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 446471000531 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 446471000532 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471000533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 446471000534 active site 446471000535 phosphorylation site [posttranslational modification] 446471000536 intermolecular recognition site; other site 446471000537 dimerization interface [polypeptide binding]; other site 446471000538 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471000539 DNA binding residues [nucleotide binding] 446471000540 dimerization interface [polypeptide binding]; other site 446471000541 GAF domain; Region: GAF; cl00853 446471000542 Histidine kinase; Region: HisKA_3; pfam07730 446471000543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446471000544 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446471000545 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446471000546 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471000547 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 446471000548 putative acyl-acceptor binding pocket; other site 446471000549 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 446471000550 putative active site [active] 446471000551 Phd_YefM; Region: PhdYeFM; cl09153 446471000552 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 446471000553 DNA-binding site [nucleotide binding]; DNA binding site 446471000554 RNA-binding motif; other site 446471000555 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 446471000556 DNA-binding site [nucleotide binding]; DNA binding site 446471000557 RNA-binding motif; other site 446471000558 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 446471000559 DNA-binding site [nucleotide binding]; DNA binding site 446471000560 RNA-binding motif; other site 446471000561 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 446471000562 DNA-binding site [nucleotide binding]; DNA binding site 446471000563 RNA-binding motif; other site 446471000564 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 446471000565 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 446471000566 dimer interface [polypeptide binding]; other site 446471000567 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 446471000568 chaperone protein DnaJ; Provisional; Region: PRK14295 446471000569 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446471000570 HSP70 interaction site [polypeptide binding]; other site 446471000571 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 446471000572 substrate binding site [polypeptide binding]; other site 446471000573 dimer interface [polypeptide binding]; other site 446471000574 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471000575 DNA binding residues [nucleotide binding] 446471000576 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446471000577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446471000578 DNA binding residues [nucleotide binding] 446471000579 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446471000580 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446471000581 nucleoside/Zn binding site; other site 446471000582 dimer interface [polypeptide binding]; other site 446471000583 catalytic motif [active] 446471000584 Domain of unknown function DUF20; Region: UPF0118; cl00465 446471000585 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471000586 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 446471000587 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446471000588 Walker A/P-loop; other site 446471000589 ATP binding site [chemical binding]; other site 446471000590 Q-loop/lid; other site 446471000591 ABC transporter signature motif; other site 446471000592 Walker B; other site 446471000593 D-loop; other site 446471000594 H-loop/switch region; other site 446471000595 Histidine kinase; Region: HisKA_3; pfam07730 446471000596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446471000597 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471000598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471000599 active site 446471000600 phosphorylation site [posttranslational modification] 446471000601 intermolecular recognition site; other site 446471000602 dimerization interface [polypeptide binding]; other site 446471000603 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471000604 DNA binding residues [nucleotide binding] 446471000605 Uncharacterized conserved protein [Function unknown]; Region: COG3595 446471000606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471000607 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 446471000608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471000609 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 446471000610 Glyco_18 domain; Region: Glyco_18; smart00636 446471000611 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 446471000612 active site 446471000613 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 446471000614 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 446471000615 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 446471000616 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446471000617 NAD(P) binding site [chemical binding]; other site 446471000618 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446471000619 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 446471000620 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 446471000621 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446471000622 acyl-coenzyme A oxidase; Region: PLN02526 446471000623 active site 446471000624 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 446471000625 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446471000626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471000627 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 446471000628 DXD motif; other site 446471000629 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446471000630 carboxyltransferase (CT) interaction site; other site 446471000631 biotinylation site [posttranslational modification]; other site 446471000632 multidrug resistance protein MdtN; Provisional; Region: PRK10476 446471000633 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 446471000634 Permease family; Region: Xan_ur_permease; cl00967 446471000635 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 446471000636 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446471000637 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446471000638 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446471000639 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446471000640 FAD binding pocket [chemical binding]; other site 446471000641 FAD binding motif [chemical binding]; other site 446471000642 phosphate binding motif [ion binding]; other site 446471000643 NAD binding pocket [chemical binding]; other site 446471000644 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446471000645 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471000646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471000647 active site 446471000648 phosphorylation site [posttranslational modification] 446471000649 intermolecular recognition site; other site 446471000650 dimerization interface [polypeptide binding]; other site 446471000651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471000652 DNA binding residues [nucleotide binding] 446471000653 dimerization interface [polypeptide binding]; other site 446471000654 Histidine kinase; Region: HisKA_3; pfam07730 446471000655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446471000656 Uncharacterized conserved protein [Function unknown]; Region: COG4748 446471000657 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 446471000658 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471000659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 446471000660 active site 446471000661 phosphorylation site [posttranslational modification] 446471000662 intermolecular recognition site; other site 446471000663 dimerization interface [polypeptide binding]; other site 446471000664 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471000665 DNA binding residues [nucleotide binding] 446471000666 dimerization interface [polypeptide binding]; other site 446471000667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 446471000668 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 446471000669 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 446471000670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446471000671 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 446471000672 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 446471000673 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 446471000674 Walker A/P-loop; other site 446471000675 ATP binding site [chemical binding]; other site 446471000676 Q-loop/lid; other site 446471000677 ABC transporter signature motif; other site 446471000678 Walker B; other site 446471000679 D-loop; other site 446471000680 H-loop/switch region; other site 446471000681 NIL domain; Region: NIL; cl09633 446471000682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471000683 dimer interface [polypeptide binding]; other site 446471000684 conserved gate region; other site 446471000685 ABC-ATPase subunit interface; other site 446471000686 Phd_YefM; Region: PhdYeFM; cl09153 446471000687 Fic/DOC family; Region: Fic; cl00960 446471000688 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 446471000689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471000690 Walker A motif; other site 446471000691 ATP binding site [chemical binding]; other site 446471000692 Walker B motif; other site 446471000693 arginine finger; other site 446471000694 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 446471000695 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 446471000696 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 446471000697 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446471000698 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 446471000699 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 446471000700 Walker A/P-loop; other site 446471000701 ATP binding site [chemical binding]; other site 446471000702 Q-loop/lid; other site 446471000703 ABC transporter signature motif; other site 446471000704 Walker B; other site 446471000705 D-loop; other site 446471000706 H-loop/switch region; other site 446471000707 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 446471000708 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446471000709 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446471000710 TM-ABC transporter signature motif; other site 446471000711 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 446471000712 putative ligand binding site [chemical binding]; other site 446471000713 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 446471000714 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 446471000715 catalytic site [active] 446471000716 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446471000717 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446471000718 substrate binding site [chemical binding]; other site 446471000719 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446471000720 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446471000721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471000722 dimer interface [polypeptide binding]; other site 446471000723 conserved gate region; other site 446471000724 putative PBP binding loops; other site 446471000725 ABC-ATPase subunit interface; other site 446471000726 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 446471000727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471000728 dimer interface [polypeptide binding]; other site 446471000729 conserved gate region; other site 446471000730 ABC-ATPase subunit interface; other site 446471000731 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446471000732 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471000733 Walker A/P-loop; other site 446471000734 ATP binding site [chemical binding]; other site 446471000735 Q-loop/lid; other site 446471000736 ABC transporter signature motif; other site 446471000737 Walker B; other site 446471000738 D-loop; other site 446471000739 H-loop/switch region; other site 446471000740 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471000741 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471000742 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446471000743 Walker A/P-loop; other site 446471000744 ATP binding site [chemical binding]; other site 446471000745 Q-loop/lid; other site 446471000746 ABC transporter signature motif; other site 446471000747 Walker B; other site 446471000748 D-loop; other site 446471000749 H-loop/switch region; other site 446471000750 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471000751 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446471000752 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 446471000753 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 446471000754 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 446471000755 dimerization interface [polypeptide binding]; other site 446471000756 putative active cleft [active] 446471000757 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446471000758 substrate binding site [chemical binding]; other site 446471000759 ATP binding site [chemical binding]; other site 446471000760 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 446471000761 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 446471000762 recombination protein RecR; Reviewed; Region: recR; PRK00076 446471000763 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446471000764 RecR protein; Region: RecR; pfam02132 446471000765 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 446471000766 putative active site [active] 446471000767 putative metal-binding site [ion binding]; other site 446471000768 tetramer interface [polypeptide binding]; other site 446471000769 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 446471000770 Catalytic site; other site 446471000771 Excalibur calcium-binding domain; Region: Excalibur; cl05460 446471000772 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446471000773 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471000774 Walker A/P-loop; other site 446471000775 ATP binding site [chemical binding]; other site 446471000776 Q-loop/lid; other site 446471000777 ABC transporter signature motif; other site 446471000778 Walker B; other site 446471000779 D-loop; other site 446471000780 H-loop/switch region; other site 446471000781 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446471000782 active site 446471000783 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 446471000784 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446471000785 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471000786 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 446471000787 aspartate kinase; Reviewed; Region: PRK06635 446471000788 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 446471000789 putative nucleotide binding site [chemical binding]; other site 446471000790 putative catalytic residues [active] 446471000791 putative Mg ion binding site [ion binding]; other site 446471000792 putative aspartate binding site [chemical binding]; other site 446471000793 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 446471000794 putative allosteric regulatory site; other site 446471000795 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 446471000796 putative allosteric regulatory residue; other site 446471000797 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 446471000798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471000799 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 446471000800 Uncharacterized conserved protein [Function unknown]; Region: COG4715 446471000801 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 446471000802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471000803 ATP binding site [chemical binding]; other site 446471000804 putative Mg++ binding site [ion binding]; other site 446471000805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471000806 nucleotide binding region [chemical binding]; other site 446471000807 ATP-binding site [chemical binding]; other site 446471000808 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 446471000809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471000810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471000811 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446471000812 NAD(P) binding site [chemical binding]; other site 446471000813 active site 446471000814 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446471000815 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471000816 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446471000817 ATP binding site [chemical binding]; other site 446471000818 putative Mg++ binding site [ion binding]; other site 446471000819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471000820 nucleotide binding region [chemical binding]; other site 446471000821 ATP-binding site [chemical binding]; other site 446471000822 SelR domain; Region: SelR; cl00369 446471000823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471000824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471000825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446471000826 putative substrate translocation pore; other site 446471000827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471000828 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446471000829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471000830 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 446471000831 Phosphate transporter family; Region: PHO4; cl00396 446471000832 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 446471000833 active site 446471000834 Ap6A binding site [chemical binding]; other site 446471000835 nudix motif; other site 446471000836 metal binding site [ion binding]; metal-binding site 446471000837 polyphosphate kinase; Provisional; Region: PRK05443 446471000838 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 446471000839 putative domain interface [polypeptide binding]; other site 446471000840 putative active site [active] 446471000841 catalytic site [active] 446471000842 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 446471000843 putative domain interface [polypeptide binding]; other site 446471000844 putative active site [active] 446471000845 catalytic site [active] 446471000846 Cupin domain; Region: Cupin_2; cl09118 446471000847 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446471000848 homotrimer interaction site [polypeptide binding]; other site 446471000849 putative active site [active] 446471000850 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 446471000851 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 446471000852 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 446471000853 active site 446471000854 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 446471000855 catalytic triad [active] 446471000856 dimer interface [polypeptide binding]; other site 446471000857 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 446471000858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471000859 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 446471000860 phosphate binding site [ion binding]; other site 446471000861 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446471000862 active site 446471000863 PaaX-like protein; Region: PaaX; pfam07848 446471000864 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 446471000865 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 446471000866 active site 446471000867 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 446471000868 dimer interface [polypeptide binding]; other site 446471000869 non-prolyl cis peptide bond; other site 446471000870 insertion regions; other site 446471000871 Flavin Reductases; Region: FlaRed; cl00801 446471000872 Helix-turn-helix domain; Region: HTH_18; pfam12833 446471000873 Putative cyclase; Region: Cyclase; cl00814 446471000874 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 446471000875 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 446471000876 dimer interface [polypeptide binding]; other site 446471000877 PYR/PP interface [polypeptide binding]; other site 446471000878 TPP binding site [chemical binding]; other site 446471000879 substrate binding site [chemical binding]; other site 446471000880 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 446471000881 TPP-binding site; other site 446471000882 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 446471000883 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 446471000884 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 446471000885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446471000886 Coenzyme A binding pocket [chemical binding]; other site 446471000887 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471000888 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 446471000889 acetyl-CoA synthetase; Provisional; Region: PRK00174 446471000890 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 446471000891 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 446471000892 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 446471000893 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 446471000894 active site 446471000895 FMN binding site [chemical binding]; other site 446471000896 substrate binding site [chemical binding]; other site 446471000897 homotetramer interface [polypeptide binding]; other site 446471000898 catalytic residue [active] 446471000899 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446471000900 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 446471000901 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 446471000902 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471000903 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 446471000904 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 446471000905 ATP binding site [chemical binding]; other site 446471000906 Walker A motif; other site 446471000907 hexamer interface [polypeptide binding]; other site 446471000908 Walker B motif; other site 446471000909 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 446471000910 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471000911 ATP binding site [chemical binding]; other site 446471000912 putative Mg++ binding site [ion binding]; other site 446471000913 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 446471000914 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446471000915 active site 446471000916 metal binding site [ion binding]; metal-binding site 446471000917 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446471000918 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 446471000919 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 446471000920 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 446471000921 metal binding site [ion binding]; metal-binding site 446471000922 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446471000923 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471000924 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446471000925 DNA binding residues [nucleotide binding] 446471000926 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 446471000927 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 446471000928 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446471000929 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 446471000930 active site 446471000931 metal binding site [ion binding]; metal-binding site 446471000932 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446471000933 active site 446471000934 metal binding site [ion binding]; metal-binding site 446471000935 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471000936 DinB superfamily; Region: DinB_2; cl00986 446471000937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446471000938 S-adenosylmethionine binding site [chemical binding]; other site 446471000939 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 446471000940 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 446471000941 active site 446471000942 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 446471000943 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 446471000944 active site 446471000945 interdomain interaction site; other site 446471000946 putative metal-binding site [ion binding]; other site 446471000947 nucleotide binding site [chemical binding]; other site 446471000948 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 446471000949 domain I; other site 446471000950 phosphate binding site [ion binding]; other site 446471000951 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 446471000952 domain II; other site 446471000953 domain III; other site 446471000954 nucleotide binding site [chemical binding]; other site 446471000955 DNA binding groove [nucleotide binding] 446471000956 catalytic site [active] 446471000957 domain IV; other site 446471000958 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 446471000959 FtsX-like permease family; Region: FtsX; pfam02687 446471000960 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 446471000961 FtsX-like permease family; Region: FtsX; pfam02687 446471000962 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471000963 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471000964 Walker A/P-loop; other site 446471000965 ATP binding site [chemical binding]; other site 446471000966 Q-loop/lid; other site 446471000967 ABC transporter signature motif; other site 446471000968 Walker B; other site 446471000969 D-loop; other site 446471000970 H-loop/switch region; other site 446471000971 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446471000972 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446471000973 catalytic residue [active] 446471000974 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446471000975 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 446471000976 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 446471000977 dimerization interface [polypeptide binding]; other site 446471000978 active site 446471000979 L-aspartate oxidase; Provisional; Region: PRK07804 446471000980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471000981 domain; Region: Succ_DH_flav_C; pfam02910 446471000982 Quinolinate synthetase A protein; Region: NadA; cl00420 446471000983 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446471000984 nudix motif; other site 446471000985 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446471000986 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446471000987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471000988 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446471000989 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 446471000990 thymidylate kinase; Validated; Region: tmk; PRK00698 446471000991 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 446471000992 TMP-binding site; other site 446471000993 ATP-binding site [chemical binding]; other site 446471000994 DNA polymerase III subunit delta'; Validated; Region: PRK07940 446471000995 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471000996 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446471000997 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471000998 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446471000999 active site 446471001000 catalytic residues [active] 446471001001 metal binding site [ion binding]; metal-binding site 446471001002 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 446471001003 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 446471001004 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446471001005 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446471001006 Clp protease ATP binding subunit; Region: clpC; CHL00095 446471001007 Clp amino terminal domain; Region: Clp_N; pfam02861 446471001008 Clp amino terminal domain; Region: Clp_N; pfam02861 446471001009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471001010 Walker A motif; other site 446471001011 ATP binding site [chemical binding]; other site 446471001012 Walker B motif; other site 446471001013 arginine finger; other site 446471001014 UvrB/uvrC motif; Region: UVR; pfam02151 446471001015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471001016 Walker A motif; other site 446471001017 ATP binding site [chemical binding]; other site 446471001018 Walker B motif; other site 446471001019 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 446471001020 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446471001021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446471001022 motif II; other site 446471001023 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446471001024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471001025 NAD(P) binding site [chemical binding]; other site 446471001026 active site 446471001027 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471001028 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471001029 DNA binding site [nucleotide binding] 446471001030 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 446471001031 putative dimerization interface [polypeptide binding]; other site 446471001032 putative ligand binding site [chemical binding]; other site 446471001033 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446471001034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471001035 dimer interface [polypeptide binding]; other site 446471001036 conserved gate region; other site 446471001037 putative PBP binding loops; other site 446471001038 ABC-ATPase subunit interface; other site 446471001039 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471001040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446471001041 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471001042 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 446471001043 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 446471001044 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 446471001045 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471001046 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471001047 DNA binding site [nucleotide binding] 446471001048 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446471001049 ligand binding site [chemical binding]; other site 446471001050 dimerization interface [polypeptide binding]; other site 446471001051 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446471001052 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001053 active site 446471001054 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446471001055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446471001056 DNA-binding site [nucleotide binding]; DNA binding site 446471001057 FCD domain; Region: FCD; cl11656 446471001058 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 446471001059 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446471001060 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446471001061 FAD binding domain; Region: FAD_binding_4; pfam01565 446471001062 Berberine and berberine like; Region: BBE; pfam08031 446471001063 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 446471001064 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446471001065 active site 446471001066 catalytic tetrad [active] 446471001067 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446471001068 substrate binding site [chemical binding]; other site 446471001069 ATP binding site [chemical binding]; other site 446471001070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471001071 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471001072 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471001073 Walker A/P-loop; other site 446471001074 ATP binding site [chemical binding]; other site 446471001075 Q-loop/lid; other site 446471001076 ABC transporter signature motif; other site 446471001077 Walker B; other site 446471001078 D-loop; other site 446471001079 H-loop/switch region; other site 446471001080 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446471001081 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 446471001082 Protein of unknown function (DUF808); Region: DUF808; cl01002 446471001083 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 446471001084 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 446471001085 active site 446471001086 substrate-binding site [chemical binding]; other site 446471001087 metal-binding site [ion binding] 446471001088 GTP binding site [chemical binding]; other site 446471001089 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 446471001090 Domain of unknown function (DUF955); Region: DUF955; cl01076 446471001091 glycerol kinase; Provisional; Region: glpK; PRK00047 446471001092 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 446471001093 N- and C-terminal domain interface [polypeptide binding]; other site 446471001094 putative active site [active] 446471001095 putative MgATP binding site [chemical binding]; other site 446471001096 catalytic site [active] 446471001097 metal binding site [ion binding]; metal-binding site 446471001098 putative homotetramer interface [polypeptide binding]; other site 446471001099 putative glycerol binding site [chemical binding]; other site 446471001100 homodimer interface [polypeptide binding]; other site 446471001101 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 446471001102 amphipathic channel; other site 446471001103 Asn-Pro-Ala signature motifs; other site 446471001104 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 446471001105 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 446471001106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446471001107 Coenzyme A binding pocket [chemical binding]; other site 446471001108 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 446471001109 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446471001110 minor groove reading motif; other site 446471001111 helix-hairpin-helix signature motif; other site 446471001112 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 446471001113 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 446471001114 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 446471001115 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 446471001116 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446471001117 DNA repair protein RadA; Provisional; Region: PRK11823 446471001118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001119 Walker A motif; other site 446471001120 ATP binding site [chemical binding]; other site 446471001121 Walker B motif; other site 446471001122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471001123 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471001124 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471001125 DNA binding site [nucleotide binding] 446471001126 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446471001127 ligand binding site [chemical binding]; other site 446471001128 dimerization interface (open form) [polypeptide binding]; other site 446471001129 dimerization interface (closed form) [polypeptide binding]; other site 446471001130 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 446471001131 N- and C-terminal domain interface [polypeptide binding]; other site 446471001132 active site 446471001133 MgATP binding site [chemical binding]; other site 446471001134 catalytic site [active] 446471001135 metal binding site [ion binding]; metal-binding site 446471001136 carbohydrate binding site [chemical binding]; other site 446471001137 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 446471001138 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 446471001139 intersubunit interface [polypeptide binding]; other site 446471001140 active site 446471001141 Zn2+ binding site [ion binding]; other site 446471001142 L-arabinose isomerase; Provisional; Region: PRK02929 446471001143 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 446471001144 hexamer (dimer of trimers) interface [polypeptide binding]; other site 446471001145 trimer interface [polypeptide binding]; other site 446471001146 substrate binding site [chemical binding]; other site 446471001147 Mn binding site [ion binding]; other site 446471001148 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 446471001149 putative ligand binding site [chemical binding]; other site 446471001150 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 446471001151 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 446471001152 Walker A/P-loop; other site 446471001153 ATP binding site [chemical binding]; other site 446471001154 Q-loop/lid; other site 446471001155 ABC transporter signature motif; other site 446471001156 Walker B; other site 446471001157 D-loop; other site 446471001158 H-loop/switch region; other site 446471001159 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 446471001160 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 446471001161 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446471001162 TM-ABC transporter signature motif; other site 446471001163 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 446471001164 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471001165 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471001166 DNA binding site [nucleotide binding] 446471001167 domain linker motif; other site 446471001168 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446471001169 dimerization interface [polypeptide binding]; other site 446471001170 ligand binding site [chemical binding]; other site 446471001171 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446471001172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471001173 putative PBP binding loops; other site 446471001174 ABC-ATPase subunit interface; other site 446471001175 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471001176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471001177 dimer interface [polypeptide binding]; other site 446471001178 conserved gate region; other site 446471001179 putative PBP binding loops; other site 446471001180 ABC-ATPase subunit interface; other site 446471001181 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471001182 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471001183 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446471001184 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 446471001185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446471001186 DNA-binding site [nucleotide binding]; DNA binding site 446471001187 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446471001188 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446471001189 Walker A/P-loop; other site 446471001190 ATP binding site [chemical binding]; other site 446471001191 Q-loop/lid; other site 446471001192 ABC transporter signature motif; other site 446471001193 Walker B; other site 446471001194 D-loop; other site 446471001195 H-loop/switch region; other site 446471001196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471001197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471001198 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446471001199 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446471001200 Walker A/P-loop; other site 446471001201 ATP binding site [chemical binding]; other site 446471001202 Q-loop/lid; other site 446471001203 ABC transporter signature motif; other site 446471001204 Walker B; other site 446471001205 D-loop; other site 446471001206 H-loop/switch region; other site 446471001207 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446471001208 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 446471001209 putative ligand binding site [chemical binding]; other site 446471001210 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446471001211 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 446471001212 Walker A/P-loop; other site 446471001213 ATP binding site [chemical binding]; other site 446471001214 Q-loop/lid; other site 446471001215 ABC transporter signature motif; other site 446471001216 Walker B; other site 446471001217 D-loop; other site 446471001218 H-loop/switch region; other site 446471001219 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 446471001220 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446471001221 TM-ABC transporter signature motif; other site 446471001222 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446471001223 TM-ABC transporter signature motif; other site 446471001224 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446471001225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471001226 dimer interface [polypeptide binding]; other site 446471001227 conserved gate region; other site 446471001228 putative PBP binding loops; other site 446471001229 ABC-ATPase subunit interface; other site 446471001230 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446471001231 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 446471001232 Walker A/P-loop; other site 446471001233 ATP binding site [chemical binding]; other site 446471001234 Q-loop/lid; other site 446471001235 ABC transporter signature motif; other site 446471001236 Walker B; other site 446471001237 D-loop; other site 446471001238 H-loop/switch region; other site 446471001239 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 446471001240 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 446471001241 substrate binding pocket [chemical binding]; other site 446471001242 membrane-bound complex binding site; other site 446471001243 Sulfatase; Region: Sulfatase; cl10460 446471001244 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446471001245 Interdomain contacts; other site 446471001246 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446471001247 Interdomain contacts; other site 446471001248 Cytokine receptor motif; other site 446471001249 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446471001250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471001251 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 446471001252 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 446471001253 Cation transport protein; Region: TrkH; cl10514 446471001254 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 446471001255 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 446471001256 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446471001257 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 446471001258 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 446471001259 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446471001260 active site 446471001261 catalytic tetrad [active] 446471001262 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 446471001263 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 446471001264 active site 446471001265 non-prolyl cis peptide bond; other site 446471001266 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 446471001267 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471001268 Walker A/P-loop; other site 446471001269 ATP binding site [chemical binding]; other site 446471001270 Q-loop/lid; other site 446471001271 ABC transporter signature motif; other site 446471001272 Walker B; other site 446471001273 D-loop; other site 446471001274 H-loop/switch region; other site 446471001275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446471001276 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 446471001277 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446471001278 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 446471001279 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446471001280 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 446471001281 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 446471001282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471001283 YceI-like domain; Region: YceI; cl01001 446471001284 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446471001285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471001286 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446471001287 catalytic core [active] 446471001288 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 446471001289 catalytic residues [active] 446471001290 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 446471001291 ResB-like family; Region: ResB; pfam05140 446471001292 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 446471001293 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 446471001294 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 446471001295 UbiA prenyltransferase family; Region: UbiA; cl00337 446471001296 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 446471001297 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 446471001298 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 446471001299 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 446471001300 Predicted transcriptional regulator [Transcription]; Region: COG5340 446471001301 naphthoate synthase; Validated; Region: PRK08321 446471001302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446471001303 substrate binding site [chemical binding]; other site 446471001304 oxyanion hole (OAH) forming residues; other site 446471001305 trimer interface [polypeptide binding]; other site 446471001306 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 446471001307 metal binding site [ion binding]; metal-binding site 446471001308 substrate binding pocket [chemical binding]; other site 446471001309 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 446471001310 PYR/PP interface [polypeptide binding]; other site 446471001311 dimer interface [polypeptide binding]; other site 446471001312 TPP binding site [chemical binding]; other site 446471001313 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 446471001314 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 446471001315 TPP-binding site; other site 446471001316 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446471001317 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 446471001318 protein binding site [polypeptide binding]; other site 446471001319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471001320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471001321 Protein of unknown function (DUF433); Region: DUF433; cl01030 446471001322 putative efflux protein, MATE family; Region: matE; TIGR00797 446471001323 MatE; Region: MatE; cl10513 446471001324 MatE; Region: MatE; cl10513 446471001325 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 446471001326 chorismate binding enzyme; Region: Chorismate_bind; cl10555 446471001327 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 446471001328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446471001329 S-adenosylmethionine binding site [chemical binding]; other site 446471001330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471001331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471001332 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 446471001333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471001334 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 446471001335 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 446471001336 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 446471001337 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 446471001338 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 446471001339 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 446471001340 putative dimer interface [polypeptide binding]; other site 446471001341 [2Fe-2S] cluster binding site [ion binding]; other site 446471001342 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 446471001343 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 446471001344 SLBB domain; Region: SLBB; pfam10531 446471001345 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 446471001346 NADH dehydrogenase subunit G; Validated; Region: PRK07860 446471001347 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446471001348 catalytic loop [active] 446471001349 iron binding site [ion binding]; other site 446471001350 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 446471001351 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446471001352 molybdopterin cofactor binding site; other site 446471001353 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 446471001354 NADH dehydrogenase; Region: NADHdh; cl00469 446471001355 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 446471001356 4Fe-4S binding domain; Region: Fer4; cl02805 446471001357 4Fe-4S binding domain; Region: Fer4; cl02805 446471001358 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 446471001359 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 446471001360 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 446471001361 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 446471001362 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 446471001363 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 446471001364 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 446471001365 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 446471001366 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 446471001367 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 446471001368 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446471001369 substrate binding pocket [chemical binding]; other site 446471001370 chain length determination region; other site 446471001371 substrate-Mg2+ binding site; other site 446471001372 catalytic residues [active] 446471001373 aspartate-rich region 1; other site 446471001374 active site lid residues [active] 446471001375 aspartate-rich region 2; other site 446471001376 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446471001377 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446471001378 Interdomain contacts; other site 446471001379 MoxR-like ATPases [General function prediction only]; Region: COG0714 446471001380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471001381 Walker A motif; other site 446471001382 ATP binding site [chemical binding]; other site 446471001383 Walker B motif; other site 446471001384 arginine finger; other site 446471001385 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446471001386 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446471001387 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 446471001388 RDD family; Region: RDD; cl00746 446471001389 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 446471001390 Protein phosphatase 2C; Region: PP2C; pfam00481 446471001391 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446471001392 active site 446471001393 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 446471001394 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446471001395 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446471001396 active site 446471001397 ATP binding site [chemical binding]; other site 446471001398 substrate binding site [chemical binding]; other site 446471001399 activation loop (A-loop); other site 446471001400 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446471001401 phosphopeptide binding site; other site 446471001402 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 446471001403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001404 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001405 Proteins of 100 residues with WXG; Region: WXG100; cl02005 446471001406 Proteins of 100 residues with WXG; Region: WXG100; cl02005 446471001407 Proteins of 100 residues with WXG; Region: WXG100; cl02005 446471001408 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 446471001409 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 446471001410 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 446471001411 ferredoxin-NADP+ reductase; Region: PLN02852 446471001412 hypothetical protein; Provisional; Region: PRK09897 446471001413 Peptidase family M48; Region: Peptidase_M48; cl12018 446471001414 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 446471001415 Cellulose binding domain; Region: CBM_2; cl02709 446471001416 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 446471001417 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 446471001418 Protein of unknown function (DUF520); Region: DUF520; cl00723 446471001419 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 446471001420 Phage Tail Collar Domain; Region: Collar; pfam07484 446471001421 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 446471001422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 446471001423 BRO family, N-terminal domain; Region: Bro-N; cl10591 446471001424 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 446471001425 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471001426 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 446471001427 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 446471001428 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 446471001429 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 446471001430 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 446471001431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 446471001432 Terminase-like family; Region: Terminase_6; pfam03237 446471001433 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 446471001434 primosome assembly protein PriA; Provisional; Region: PRK14873 446471001435 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 446471001436 ADP-ribose binding site [chemical binding]; other site 446471001437 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 446471001438 Transcription factor WhiB; Region: Whib; pfam02467 446471001439 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 446471001440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471001441 cofactor binding site; other site 446471001442 DNA binding site [nucleotide binding] 446471001443 substrate interaction site [chemical binding]; other site 446471001444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471001445 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446471001446 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001447 Walker A motif; other site 446471001448 ATP binding site [chemical binding]; other site 446471001449 Walker B motif; other site 446471001450 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446471001451 active site 446471001452 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 446471001453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471001454 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446471001455 dimer interface [polypeptide binding]; other site 446471001456 ssDNA binding site [nucleotide binding]; other site 446471001457 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446471001458 RecT family; Region: RecT; cl04285 446471001459 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 446471001460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471001461 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 446471001462 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 446471001463 Phage integrase family; Region: Phage_integrase; pfam00589 446471001464 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446471001465 DNA binding site [nucleotide binding] 446471001466 Int/Topo IB signature motif; other site 446471001467 active site 446471001468 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 446471001469 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 446471001470 active site 446471001471 catalytic site [active] 446471001472 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446471001473 active site 2 [active] 446471001474 active site 1 [active] 446471001475 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471001476 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471001477 DNA binding site [nucleotide binding] 446471001478 domain linker motif; other site 446471001479 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446471001480 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 446471001481 FAD binding domain; Region: FAD_binding_4; pfam01565 446471001482 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 446471001483 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 446471001484 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 446471001485 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446471001486 Adenosine/AMP deaminase; Region: A_deaminase; pfam00962 446471001487 active site 446471001488 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471001489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471001490 active site 446471001491 phosphorylation site [posttranslational modification] 446471001492 intermolecular recognition site; other site 446471001493 dimerization interface [polypeptide binding]; other site 446471001494 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471001495 DNA binding residues [nucleotide binding] 446471001496 dimerization interface [polypeptide binding]; other site 446471001497 Histidine kinase; Region: HisKA_3; pfam07730 446471001498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471001499 ATP binding site [chemical binding]; other site 446471001500 Mg2+ binding site [ion binding]; other site 446471001501 G-X-G motif; other site 446471001502 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446471001503 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446471001504 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446471001505 Walker A/P-loop; other site 446471001506 ATP binding site [chemical binding]; other site 446471001507 Q-loop/lid; other site 446471001508 ABC transporter signature motif; other site 446471001509 Walker B; other site 446471001510 D-loop; other site 446471001511 H-loop/switch region; other site 446471001512 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 446471001513 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 446471001514 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 446471001515 putative homodimer interface [polypeptide binding]; other site 446471001516 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 446471001517 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 446471001518 23S rRNA interface [nucleotide binding]; other site 446471001519 L7/L12 interface [polypeptide binding]; other site 446471001520 putative thiostrepton binding site; other site 446471001521 L25 interface [polypeptide binding]; other site 446471001522 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 446471001523 mRNA/rRNA interface [nucleotide binding]; other site 446471001524 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446471001525 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 446471001526 active site 446471001527 catalytic residues [active] 446471001528 CHAT domain; Region: CHAT; cl02083 446471001529 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 446471001530 23S rRNA interface [nucleotide binding]; other site 446471001531 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 446471001532 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 446471001533 core dimer interface [polypeptide binding]; other site 446471001534 peripheral dimer interface [polypeptide binding]; other site 446471001535 L10 interface [polypeptide binding]; other site 446471001536 L11 interface [polypeptide binding]; other site 446471001537 putative EF-Tu interaction site [polypeptide binding]; other site 446471001538 putative EF-G interaction site [polypeptide binding]; other site 446471001539 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 446471001540 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 446471001541 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 446471001542 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 446471001543 RPB1 interaction site [polypeptide binding]; other site 446471001544 RPB10 interaction site [polypeptide binding]; other site 446471001545 RPB11 interaction site [polypeptide binding]; other site 446471001546 RPB3 interaction site [polypeptide binding]; other site 446471001547 RPB12 interaction site [polypeptide binding]; other site 446471001548 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 446471001549 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 446471001550 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 446471001551 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 446471001552 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 446471001553 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 446471001554 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 446471001555 G-loop; other site 446471001556 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 446471001557 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 446471001558 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 446471001559 DNA binding site [nucleotide binding] 446471001560 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 446471001561 S17 interaction site [polypeptide binding]; other site 446471001562 S8 interaction site; other site 446471001563 16S rRNA interaction site [nucleotide binding]; other site 446471001564 streptomycin interaction site [chemical binding]; other site 446471001565 23S rRNA interaction site [nucleotide binding]; other site 446471001566 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 446471001567 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 446471001568 elongation factor G; Reviewed; Region: PRK00007 446471001569 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 446471001570 G1 box; other site 446471001571 putative GEF interaction site [polypeptide binding]; other site 446471001572 GTP/Mg2+ binding site [chemical binding]; other site 446471001573 Switch I region; other site 446471001574 G2 box; other site 446471001575 G3 box; other site 446471001576 Switch II region; other site 446471001577 G4 box; other site 446471001578 G5 box; other site 446471001579 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 446471001580 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 446471001581 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 446471001582 elongation factor Tu; Reviewed; Region: PRK00049 446471001583 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 446471001584 G1 box; other site 446471001585 GEF interaction site [polypeptide binding]; other site 446471001586 GTP/Mg2+ binding site [chemical binding]; other site 446471001587 Switch I region; other site 446471001588 G2 box; other site 446471001589 G3 box; other site 446471001590 Switch II region; other site 446471001591 G4 box; other site 446471001592 G5 box; other site 446471001593 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 446471001594 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 446471001595 Antibiotic Binding Site [chemical binding]; other site 446471001596 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 446471001597 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 446471001598 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 446471001599 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 446471001600 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 446471001601 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 446471001602 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 446471001603 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 446471001604 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 446471001605 putative translocon binding site; other site 446471001606 protein-rRNA interface [nucleotide binding]; other site 446471001607 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 446471001608 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 446471001609 G-X-X-G motif; other site 446471001610 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 446471001611 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 446471001612 23S rRNA interface [nucleotide binding]; other site 446471001613 5S rRNA interface [nucleotide binding]; other site 446471001614 putative antibiotic binding site [chemical binding]; other site 446471001615 L25 interface [polypeptide binding]; other site 446471001616 L27 interface [polypeptide binding]; other site 446471001617 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 446471001618 L23 interface [polypeptide binding]; other site 446471001619 signal recognition particle (SRP54) interaction site; other site 446471001620 trigger factor interaction site; other site 446471001621 23S rRNA interface [nucleotide binding]; other site 446471001622 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 446471001623 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 446471001624 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 446471001625 KOW motif; Region: KOW; cl00354 446471001626 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 446471001627 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 446471001628 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 446471001629 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 446471001630 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 446471001631 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 446471001632 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446471001633 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446471001634 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 446471001635 5S rRNA interface [nucleotide binding]; other site 446471001636 L27 interface [polypeptide binding]; other site 446471001637 23S rRNA interface [nucleotide binding]; other site 446471001638 L5 interface [polypeptide binding]; other site 446471001639 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 446471001640 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 446471001641 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 446471001642 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 446471001643 23S rRNA binding site [nucleotide binding]; other site 446471001644 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 446471001645 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 446471001646 SecY translocase; Region: SecY; pfam00344 446471001647 adenylate kinase; Reviewed; Region: adk; PRK00279 446471001648 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 446471001649 AMP-binding site [chemical binding]; other site 446471001650 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 446471001651 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446471001652 active site 446471001653 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 446471001654 rRNA binding site [nucleotide binding]; other site 446471001655 predicted 30S ribosome binding site; other site 446471001656 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 446471001657 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 446471001658 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 446471001659 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 446471001660 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 446471001661 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 446471001662 alphaNTD - beta interaction site [polypeptide binding]; other site 446471001663 alphaNTD homodimer interface [polypeptide binding]; other site 446471001664 alphaNTD - beta' interaction site [polypeptide binding]; other site 446471001665 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 446471001666 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 446471001667 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471001668 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446471001669 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 446471001670 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 446471001671 dimerization interface 3.5A [polypeptide binding]; other site 446471001672 active site 446471001673 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 446471001674 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 446471001675 23S rRNA interface [nucleotide binding]; other site 446471001676 L3 interface [polypeptide binding]; other site 446471001677 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 446471001678 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 446471001679 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 446471001680 active site 446471001681 substrate binding site [chemical binding]; other site 446471001682 metal binding site [ion binding]; metal-binding site 446471001683 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446471001684 active site 446471001685 catalytic residues [active] 446471001686 metal binding site [ion binding]; metal-binding site 446471001687 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446471001688 pantothenate kinase; Provisional; Region: PRK05439 446471001689 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 446471001690 ATP-binding site [chemical binding]; other site 446471001691 CoA-binding site [chemical binding]; other site 446471001692 Mg2+-binding site [ion binding]; other site 446471001693 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 446471001694 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 446471001695 glutaminase active site [active] 446471001696 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446471001697 dimer interface [polypeptide binding]; other site 446471001698 active site 446471001699 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 446471001700 dimer interface [polypeptide binding]; other site 446471001701 active site 446471001702 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 446471001703 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446471001704 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 446471001705 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 446471001706 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 446471001707 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446471001708 ATP binding site [chemical binding]; other site 446471001709 substrate binding site [chemical binding]; other site 446471001710 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 446471001711 catalytic residues [active] 446471001712 dimer interface [polypeptide binding]; other site 446471001713 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 446471001714 active site 446471001715 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 446471001716 alanine racemase; Reviewed; Region: alr; PRK00053 446471001717 active site 446471001718 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446471001719 dimer interface [polypeptide binding]; other site 446471001720 substrate binding site [chemical binding]; other site 446471001721 catalytic residues [active] 446471001722 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 446471001723 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 446471001724 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 446471001725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446471001726 Coenzyme A binding pocket [chemical binding]; other site 446471001727 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446471001728 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446471001729 active site residue [active] 446471001730 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446471001731 active site residue [active] 446471001732 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 446471001733 FMN binding site [chemical binding]; other site 446471001734 dimer interface [polypeptide binding]; other site 446471001735 UGMP family protein; Validated; Region: PRK09604 446471001736 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 446471001737 Scramblase; Region: Scramblase; cl02043 446471001738 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446471001739 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 446471001740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446471001741 S-adenosylmethionine binding site [chemical binding]; other site 446471001742 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 446471001743 oligomerisation interface [polypeptide binding]; other site 446471001744 mobile loop; other site 446471001745 roof hairpin; other site 446471001746 Transcription factor WhiB; Region: Whib; pfam02467 446471001747 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 446471001748 DNA binding residues [nucleotide binding] 446471001749 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 446471001750 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 446471001751 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 446471001752 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 446471001753 active site 446471001754 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446471001755 active site 446471001756 substrate binding site [chemical binding]; other site 446471001757 catalytic site [active] 446471001758 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 446471001759 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 446471001760 active site 446471001761 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446471001762 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446471001763 NAD(P) binding site [chemical binding]; other site 446471001764 catalytic residues [active] 446471001765 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 446471001766 Acetokinase family; Region: Acetate_kinase; cl01029 446471001767 phosphate acetyltransferase; Reviewed; Region: PRK05632 446471001768 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001769 DRTGG domain; Region: DRTGG; cl12147 446471001770 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 446471001771 putative phosphoketolase; Provisional; Region: PRK05261 446471001772 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 446471001773 TPP-binding site; other site 446471001774 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 446471001775 XFP C-terminal domain; Region: XFP_C; pfam09363 446471001776 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 446471001777 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 446471001778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446471001779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471001780 homodimer interface [polypeptide binding]; other site 446471001781 catalytic residue [active] 446471001782 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471001783 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471001784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001785 Walker A/P-loop; other site 446471001786 ATP binding site [chemical binding]; other site 446471001787 Q-loop/lid; other site 446471001788 ABC transporter signature motif; other site 446471001789 Walker B; other site 446471001790 D-loop; other site 446471001791 H-loop/switch region; other site 446471001792 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471001793 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471001794 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001795 Walker A/P-loop; other site 446471001796 ATP binding site [chemical binding]; other site 446471001797 Q-loop/lid; other site 446471001798 ABC transporter signature motif; other site 446471001799 Walker B; other site 446471001800 D-loop; other site 446471001801 H-loop/switch region; other site 446471001802 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471001803 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471001804 Walker A/P-loop; other site 446471001805 ATP binding site [chemical binding]; other site 446471001806 Q-loop/lid; other site 446471001807 ABC transporter signature motif; other site 446471001808 Walker B; other site 446471001809 D-loop; other site 446471001810 H-loop/switch region; other site 446471001811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471001812 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 446471001813 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 446471001814 ligand binding site [chemical binding]; other site 446471001815 GMP synthase; Reviewed; Region: guaA; PRK00074 446471001816 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 446471001817 AMP/PPi binding site [chemical binding]; other site 446471001818 candidate oxyanion hole; other site 446471001819 catalytic triad [active] 446471001820 potential glutamine specificity residues [chemical binding]; other site 446471001821 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 446471001822 ATP Binding subdomain [chemical binding]; other site 446471001823 Ligand Binding sites [chemical binding]; other site 446471001824 Dimerization subdomain; other site 446471001825 PspC domain; Region: PspC; cl00864 446471001826 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 446471001827 PspC domain; Region: PspC; cl00864 446471001828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446471001829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446471001830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471001831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 446471001832 active site 446471001833 phosphorylation site [posttranslational modification] 446471001834 intermolecular recognition site; other site 446471001835 dimerization interface [polypeptide binding]; other site 446471001836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471001837 DNA binding residues [nucleotide binding] 446471001838 dimerization interface [polypeptide binding]; other site 446471001839 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 446471001840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471001841 dimer interface [polypeptide binding]; other site 446471001842 conserved gate region; other site 446471001843 putative PBP binding loops; other site 446471001844 ABC-ATPase subunit interface; other site 446471001845 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446471001846 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 446471001847 Walker A/P-loop; other site 446471001848 ATP binding site [chemical binding]; other site 446471001849 Q-loop/lid; other site 446471001850 ABC transporter signature motif; other site 446471001851 Walker B; other site 446471001852 D-loop; other site 446471001853 H-loop/switch region; other site 446471001854 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 446471001855 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 446471001856 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 446471001857 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 446471001858 CysD dimerization site [polypeptide binding]; other site 446471001859 G1 box; other site 446471001860 putative GEF interaction site [polypeptide binding]; other site 446471001861 GTP/Mg2+ binding site [chemical binding]; other site 446471001862 Switch I region; other site 446471001863 G2 box; other site 446471001864 G3 box; other site 446471001865 Switch II region; other site 446471001866 G4 box; other site 446471001867 G5 box; other site 446471001868 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 446471001869 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 446471001870 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 446471001871 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 446471001872 Active Sites [active] 446471001873 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 446471001874 Active Sites [active] 446471001875 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 446471001876 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446471001877 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446471001878 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 446471001879 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 446471001880 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001881 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001882 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 446471001883 Clp protease ATP binding subunit; Region: clpC; CHL00095 446471001884 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 446471001885 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446471001886 CoA-ligase; Region: Ligase_CoA; pfam00549 446471001887 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 446471001888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471001889 CoA-ligase; Region: Ligase_CoA; pfam00549 446471001890 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 446471001891 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 446471001892 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 446471001893 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 446471001894 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 446471001895 Walker A/P-loop; other site 446471001896 ATP binding site [chemical binding]; other site 446471001897 Q-loop/lid; other site 446471001898 ABC transporter signature motif; other site 446471001899 Walker B; other site 446471001900 D-loop; other site 446471001901 H-loop/switch region; other site 446471001902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471001903 dimer interface [polypeptide binding]; other site 446471001904 conserved gate region; other site 446471001905 ABC-ATPase subunit interface; other site 446471001906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471001907 DNA binding site [nucleotide binding] 446471001908 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 446471001909 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 446471001910 active site 446471001911 cosubstrate binding site; other site 446471001912 substrate binding site [chemical binding]; other site 446471001913 catalytic site [active] 446471001914 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 446471001915 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 446471001916 purine monophosphate binding site [chemical binding]; other site 446471001917 dimer interface [polypeptide binding]; other site 446471001918 putative catalytic residues [active] 446471001919 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 446471001920 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 446471001921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446471001922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471001923 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 446471001924 amphipathic channel; other site 446471001925 Asn-Pro-Ala signature motifs; other site 446471001926 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 446471001927 Cellulose binding domain; Region: CBM_2; cl02709 446471001928 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 446471001929 malate dehydrogenase; Provisional; Region: PRK05442 446471001930 NAD(P) binding site [chemical binding]; other site 446471001931 LDH/MDH dimer interface [polypeptide binding]; other site 446471001932 substrate binding site [chemical binding]; other site 446471001933 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471001934 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001935 Walker A/P-loop; other site 446471001936 ATP binding site [chemical binding]; other site 446471001937 Q-loop/lid; other site 446471001938 ABC transporter signature motif; other site 446471001939 Walker B; other site 446471001940 D-loop; other site 446471001941 H-loop/switch region; other site 446471001942 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471001943 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001944 Walker A/P-loop; other site 446471001945 ATP binding site [chemical binding]; other site 446471001946 Q-loop/lid; other site 446471001947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471001948 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446471001949 hydrophobic ligand binding site; other site 446471001950 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 446471001951 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471001952 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 446471001953 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 446471001954 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 446471001955 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 446471001956 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471001957 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471001958 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 446471001959 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 446471001960 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 446471001961 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 446471001962 putative active site [active] 446471001963 putative substrate binding site [chemical binding]; other site 446471001964 putative cosubstrate binding site; other site 446471001965 catalytic site [active] 446471001966 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446471001967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446471001968 Coenzyme A binding pocket [chemical binding]; other site 446471001969 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471001970 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471001971 Walker A/P-loop; other site 446471001972 ATP binding site [chemical binding]; other site 446471001973 Q-loop/lid; other site 446471001974 ABC transporter signature motif; other site 446471001975 Walker B; other site 446471001976 D-loop; other site 446471001977 H-loop/switch region; other site 446471001978 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 446471001979 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 446471001980 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446471001981 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446471001982 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446471001983 TM-ABC transporter signature motif; other site 446471001984 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 446471001985 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 446471001986 dimer interface [polypeptide binding]; other site 446471001987 glycine-pyridoxal phosphate binding site [chemical binding]; other site 446471001988 active site 446471001989 folate binding site [chemical binding]; other site 446471001990 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 446471001991 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 446471001992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471001993 NAD(P) binding pocket [chemical binding]; other site 446471001994 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446471001995 dimer interface [polypeptide binding]; other site 446471001996 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446471001997 putative catalytic site [active] 446471001998 putative metal binding site [ion binding]; other site 446471001999 putative phosphate binding site [ion binding]; other site 446471002000 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 446471002001 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 446471002002 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 446471002003 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 446471002004 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471002005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471002006 active site 446471002007 phosphorylation site [posttranslational modification] 446471002008 intermolecular recognition site; other site 446471002009 dimerization interface [polypeptide binding]; other site 446471002010 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471002011 DNA binding residues [nucleotide binding] 446471002012 dimerization interface [polypeptide binding]; other site 446471002013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446471002014 Histidine kinase; Region: HisKA_3; pfam07730 446471002015 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 446471002016 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446471002017 Walker A/P-loop; other site 446471002018 ATP binding site [chemical binding]; other site 446471002019 Q-loop/lid; other site 446471002020 ABC transporter signature motif; other site 446471002021 Walker B; other site 446471002022 D-loop; other site 446471002023 H-loop/switch region; other site 446471002024 Domain of unknown function DUF59; Region: DUF59; cl00941 446471002025 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 446471002026 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 446471002027 Walker A motif; other site 446471002028 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002029 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 446471002030 MgtE intracellular N domain; Region: MgtE_N; cl15244 446471002031 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 446471002032 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 446471002033 proline aminopeptidase P II; Provisional; Region: PRK10879 446471002034 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 446471002035 active site 446471002036 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446471002037 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471002038 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 446471002039 MarC family integral membrane protein; Region: MarC; cl00919 446471002040 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 446471002041 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 446471002042 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446471002043 ATP binding site [chemical binding]; other site 446471002044 Mg++ binding site [ion binding]; other site 446471002045 motif III; other site 446471002046 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471002047 nucleotide binding region [chemical binding]; other site 446471002048 ATP-binding site [chemical binding]; other site 446471002049 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 446471002050 Fic family protein [Function unknown]; Region: COG3177 446471002051 Fic/DOC family; Region: Fic; cl00960 446471002052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471002053 non-specific DNA binding site [nucleotide binding]; other site 446471002054 salt bridge; other site 446471002055 sequence-specific DNA binding site [nucleotide binding]; other site 446471002056 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002057 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 446471002058 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002059 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 446471002060 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 446471002061 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446471002062 active site 446471002063 ATP binding site [chemical binding]; other site 446471002064 substrate binding site [chemical binding]; other site 446471002065 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 446471002066 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 446471002067 putative NADH binding site [chemical binding]; other site 446471002068 putative active site [active] 446471002069 nudix motif; other site 446471002070 putative metal binding site [ion binding]; other site 446471002071 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 446471002072 catalytic residues [active] 446471002073 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002074 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446471002075 HRDC domain; Region: HRDC; cl02578 446471002076 Transcription factor WhiB; Region: Whib; pfam02467 446471002077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002078 ATP binding site [chemical binding]; other site 446471002079 Protein of unknown function DUF45; Region: DUF45; cl00636 446471002080 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 446471002081 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 446471002082 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 446471002083 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 446471002084 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 446471002085 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 446471002086 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471002087 Phage integrase family; Region: Phage_integrase; pfam00589 446471002088 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446471002089 DNA binding site [nucleotide binding] 446471002090 Int/Topo IB signature motif; other site 446471002091 active site 446471002092 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 446471002093 generic binding surface I; other site 446471002094 generic binding surface II; other site 446471002095 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002096 Walker A motif; other site 446471002097 ATP binding site [chemical binding]; other site 446471002098 Walker B motif; other site 446471002099 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471002100 AAA-like domain; Region: AAA_10; pfam12846 446471002101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471002102 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446471002103 DNA binding residues [nucleotide binding] 446471002104 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 446471002105 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471002106 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471002107 Walker A/P-loop; other site 446471002108 ATP binding site [chemical binding]; other site 446471002109 Q-loop/lid; other site 446471002110 ABC transporter signature motif; other site 446471002111 Walker B; other site 446471002112 D-loop; other site 446471002113 H-loop/switch region; other site 446471002114 FtsX-like permease family; Region: FtsX; pfam02687 446471002115 TM2 domain; Region: TM2; cl00984 446471002116 Peptidase family M23; Region: Peptidase_M23; pfam01551 446471002117 ParB-like nuclease domain; Region: ParBc; cl02129 446471002118 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 446471002119 polymerase nucleotide-binding site; other site 446471002120 DNA-binding residues [nucleotide binding]; DNA binding site 446471002121 nucleotide binding site [chemical binding]; other site 446471002122 primase nucleotide-binding site [nucleotide binding]; other site 446471002123 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446471002124 nudix motif; other site 446471002125 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446471002126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002127 TadE-like protein; Region: TadE; pfam07811 446471002128 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 446471002129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002130 Walker A motif; other site 446471002131 ATP binding site [chemical binding]; other site 446471002132 Walker B motif; other site 446471002133 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446471002134 SAF domain; Region: SAF; cl00555 446471002135 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471002136 DNA binding residues [nucleotide binding] 446471002137 TrwC relaxase; Region: TrwC; cl08490 446471002138 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 446471002139 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 446471002140 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471002141 Walker A/P-loop; other site 446471002142 ATP binding site [chemical binding]; other site 446471002143 Q-loop/lid; other site 446471002144 ABC transporter signature motif; other site 446471002145 Walker B; other site 446471002146 D-loop; other site 446471002147 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 446471002148 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 446471002149 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446471002150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471002151 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446471002152 DNA binding residues [nucleotide binding] 446471002153 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 446471002154 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471002155 Walker A/P-loop; other site 446471002156 ATP binding site [chemical binding]; other site 446471002157 Q-loop/lid; other site 446471002158 ABC transporter signature motif; other site 446471002159 Walker B; other site 446471002160 D-loop; other site 446471002161 H-loop/switch region; other site 446471002162 FtsX-like permease family; Region: FtsX; pfam02687 446471002163 H+ Antiporter protein; Region: 2A0121; TIGR00900 446471002164 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446471002165 Catalytic site [active] 446471002166 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 446471002167 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 446471002168 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 446471002169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 446471002170 SEC-C motif; Region: SEC-C; pfam02810 446471002171 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 446471002172 amphipathic channel; other site 446471002173 Asn-Pro-Ala signature motifs; other site 446471002174 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 446471002175 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 446471002176 VanW like protein; Region: VanW; pfam04294 446471002177 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471002178 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471002179 DNA binding site [nucleotide binding] 446471002180 domain linker motif; other site 446471002181 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446471002182 dimerization interface [polypeptide binding]; other site 446471002183 ligand binding site [chemical binding]; other site 446471002184 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446471002185 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 446471002186 Walker A/P-loop; other site 446471002187 ATP binding site [chemical binding]; other site 446471002188 Q-loop/lid; other site 446471002189 ABC transporter signature motif; other site 446471002190 Walker B; other site 446471002191 D-loop; other site 446471002192 H-loop/switch region; other site 446471002193 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 446471002194 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446471002195 TM-ABC transporter signature motif; other site 446471002196 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446471002197 TM-ABC transporter signature motif; other site 446471002198 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 446471002199 ligand binding site [chemical binding]; other site 446471002200 Domain of unknown function (DUF718); Region: DUF718; cl01281 446471002201 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 446471002202 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 446471002203 short chain dehydrogenase; Validated; Region: PRK08324 446471002204 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 446471002205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002206 NAD(P) binding site [chemical binding]; other site 446471002207 active site 446471002208 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471002209 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471002210 DNA binding site [nucleotide binding] 446471002211 domain linker motif; other site 446471002212 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446471002213 dimerization interface [polypeptide binding]; other site 446471002214 ligand binding site [chemical binding]; other site 446471002215 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 446471002216 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 446471002217 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 446471002218 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 446471002219 Cysteine-rich domain; Region: CCG; pfam02754 446471002220 Cysteine-rich domain; Region: CCG; pfam02754 446471002221 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446471002222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002223 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446471002224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002225 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446471002226 NAD(P) binding site [chemical binding]; other site 446471002227 active site 446471002228 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 446471002229 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446471002230 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446471002231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002232 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471002233 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471002234 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446471002235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002236 dimer interface [polypeptide binding]; other site 446471002237 conserved gate region; other site 446471002238 putative PBP binding loops; other site 446471002239 ABC-ATPase subunit interface; other site 446471002240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002241 dimer interface [polypeptide binding]; other site 446471002242 conserved gate region; other site 446471002243 putative PBP binding loops; other site 446471002244 ABC-ATPase subunit interface; other site 446471002245 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 446471002246 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 446471002247 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 446471002248 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 446471002249 Vitamin K epoxide reductase family; Region: VKOR; cl01729 446471002250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471002251 Bacterial transcriptional regulator; Region: IclR; pfam01614 446471002252 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 446471002253 active site 446471002254 intersubunit interface [polypeptide binding]; other site 446471002255 catalytic residue [active] 446471002256 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 446471002257 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446471002258 substrate binding site [chemical binding]; other site 446471002259 ATP binding site [chemical binding]; other site 446471002260 Membrane transport protein; Region: Mem_trans; cl09117 446471002261 Fe-S metabolism associated domain; Region: SufE; cl00951 446471002262 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446471002263 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446471002264 active site residue [active] 446471002265 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446471002266 active site residue [active] 446471002267 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446471002268 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446471002269 NAD(P) binding site [chemical binding]; other site 446471002270 catalytic residues [active] 446471002271 Protein of unknown function (DUF779); Region: DUF779; cl01432 446471002272 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471002273 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471002274 DNA binding site [nucleotide binding] 446471002275 domain linker motif; other site 446471002276 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446471002277 ligand binding site [chemical binding]; other site 446471002278 dimerization interface (open form) [polypeptide binding]; other site 446471002279 dimerization interface (closed form) [polypeptide binding]; other site 446471002280 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471002281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471002282 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 446471002283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002284 dimer interface [polypeptide binding]; other site 446471002285 putative PBP binding loops; other site 446471002286 ABC-ATPase subunit interface; other site 446471002287 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471002288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002289 dimer interface [polypeptide binding]; other site 446471002290 conserved gate region; other site 446471002291 putative PBP binding loops; other site 446471002292 ABC-ATPase subunit interface; other site 446471002293 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 446471002294 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446471002295 domain; Region: Glyco_hydro_2; pfam00703 446471002296 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 446471002297 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 446471002298 malate synthase A; Region: malate_syn_A; TIGR01344 446471002299 active site 446471002300 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 446471002301 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446471002302 tetramer interface [polypeptide binding]; other site 446471002303 active site 446471002304 Mg2+/Mn2+ binding site [ion binding]; other site 446471002305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471002306 non-specific DNA binding site [nucleotide binding]; other site 446471002307 salt bridge; other site 446471002308 sequence-specific DNA binding site [nucleotide binding]; other site 446471002309 Domain of unknown function (DUF955); Region: DUF955; cl01076 446471002310 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 446471002311 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 446471002312 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 446471002313 putative active site [active] 446471002314 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002315 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446471002316 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 446471002317 Probable beta-xylosidase; Provisional; Region: PLN03080 446471002318 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446471002319 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446471002320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002321 dimer interface [polypeptide binding]; other site 446471002322 conserved gate region; other site 446471002323 putative PBP binding loops; other site 446471002324 ABC-ATPase subunit interface; other site 446471002325 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446471002326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002327 dimer interface [polypeptide binding]; other site 446471002328 conserved gate region; other site 446471002329 putative PBP binding loops; other site 446471002330 ABC-ATPase subunit interface; other site 446471002331 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446471002332 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471002333 Walker A/P-loop; other site 446471002334 ATP binding site [chemical binding]; other site 446471002335 Q-loop/lid; other site 446471002336 ABC transporter signature motif; other site 446471002337 Walker B; other site 446471002338 D-loop; other site 446471002339 H-loop/switch region; other site 446471002340 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471002341 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471002342 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446471002343 Walker A/P-loop; other site 446471002344 ATP binding site [chemical binding]; other site 446471002345 Q-loop/lid; other site 446471002346 ABC transporter signature motif; other site 446471002347 Walker B; other site 446471002348 D-loop; other site 446471002349 H-loop/switch region; other site 446471002350 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471002351 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446471002352 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446471002353 substrate binding site [chemical binding]; other site 446471002354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471002355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471002356 fumarate hydratase; Reviewed; Region: fumC; PRK00485 446471002357 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 446471002358 active sites [active] 446471002359 tetramer interface [polypeptide binding]; other site 446471002360 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 446471002361 active site clefts [active] 446471002362 zinc binding site [ion binding]; other site 446471002363 dimer interface [polypeptide binding]; other site 446471002364 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 446471002365 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446471002366 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002367 Walker A/P-loop; other site 446471002368 ATP binding site [chemical binding]; other site 446471002369 Q-loop/lid; other site 446471002370 ABC transporter signature motif; other site 446471002371 Walker B; other site 446471002372 D-loop; other site 446471002373 H-loop/switch region; other site 446471002374 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 446471002375 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 446471002376 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 446471002377 generic binding surface II; other site 446471002378 generic binding surface I; other site 446471002379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002380 NAD(P) binding site [chemical binding]; other site 446471002381 active site 446471002382 LytB protein; Region: LYTB; cl00507 446471002383 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 446471002384 RmuC family; Region: RmuC; pfam02646 446471002385 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 446471002386 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446471002387 Walker A/P-loop; other site 446471002388 ATP binding site [chemical binding]; other site 446471002389 Q-loop/lid; other site 446471002390 ABC transporter signature motif; other site 446471002391 Walker B; other site 446471002392 D-loop; other site 446471002393 H-loop/switch region; other site 446471002394 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 446471002395 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446471002396 GTP-binding protein YchF; Reviewed; Region: PRK09601 446471002397 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 446471002398 G1 box; other site 446471002399 GTP/Mg2+ binding site [chemical binding]; other site 446471002400 Switch I region; other site 446471002401 G2 box; other site 446471002402 Switch II region; other site 446471002403 G3 box; other site 446471002404 G4 box; other site 446471002405 G5 box; other site 446471002406 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 446471002407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471002408 non-specific DNA binding site [nucleotide binding]; other site 446471002409 salt bridge; other site 446471002410 sequence-specific DNA binding site [nucleotide binding]; other site 446471002411 HipA-like N-terminal domain; Region: HipA_N; pfam07805 446471002412 HipA-like C-terminal domain; Region: HipA_C; pfam07804 446471002413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471002414 non-specific DNA binding site [nucleotide binding]; other site 446471002415 salt bridge; other site 446471002416 sequence-specific DNA binding site [nucleotide binding]; other site 446471002417 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 446471002418 putative hydrophobic ligand binding site [chemical binding]; other site 446471002419 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446471002420 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446471002421 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446471002422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002423 dimer interface [polypeptide binding]; other site 446471002424 conserved gate region; other site 446471002425 putative PBP binding loops; other site 446471002426 ABC-ATPase subunit interface; other site 446471002427 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446471002428 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446471002429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002430 dimer interface [polypeptide binding]; other site 446471002431 conserved gate region; other site 446471002432 putative PBP binding loops; other site 446471002433 ABC-ATPase subunit interface; other site 446471002434 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446471002435 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471002436 Walker A/P-loop; other site 446471002437 ATP binding site [chemical binding]; other site 446471002438 Q-loop/lid; other site 446471002439 ABC transporter signature motif; other site 446471002440 Walker B; other site 446471002441 D-loop; other site 446471002442 H-loop/switch region; other site 446471002443 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471002444 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 446471002445 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471002446 Walker A/P-loop; other site 446471002447 ATP binding site [chemical binding]; other site 446471002448 Q-loop/lid; other site 446471002449 ABC transporter signature motif; other site 446471002450 Walker B; other site 446471002451 D-loop; other site 446471002452 H-loop/switch region; other site 446471002453 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471002454 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 446471002455 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446471002456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002457 putative PBP binding loops; other site 446471002458 dimer interface [polypeptide binding]; other site 446471002459 ABC-ATPase subunit interface; other site 446471002460 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 446471002461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002462 dimer interface [polypeptide binding]; other site 446471002463 conserved gate region; other site 446471002464 putative PBP binding loops; other site 446471002465 ABC-ATPase subunit interface; other site 446471002466 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446471002467 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446471002468 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471002469 Walker A/P-loop; other site 446471002470 ATP binding site [chemical binding]; other site 446471002471 Q-loop/lid; other site 446471002472 ABC transporter signature motif; other site 446471002473 Walker B; other site 446471002474 D-loop; other site 446471002475 H-loop/switch region; other site 446471002476 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471002477 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471002478 Walker A/P-loop; other site 446471002479 ATP binding site [chemical binding]; other site 446471002480 Q-loop/lid; other site 446471002481 ABC transporter signature motif; other site 446471002482 Walker B; other site 446471002483 D-loop; other site 446471002484 H-loop/switch region; other site 446471002485 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471002486 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 446471002487 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 446471002488 G1 box; other site 446471002489 putative GEF interaction site [polypeptide binding]; other site 446471002490 GTP/Mg2+ binding site [chemical binding]; other site 446471002491 Switch I region; other site 446471002492 G2 box; other site 446471002493 G3 box; other site 446471002494 Switch II region; other site 446471002495 G4 box; other site 446471002496 G5 box; other site 446471002497 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 446471002498 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 446471002499 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446471002500 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446471002501 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446471002502 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 446471002503 VanW like protein; Region: VanW; pfam04294 446471002504 prephenate dehydratase; Provisional; Region: PRK11898 446471002505 Prephenate dehydratase; Region: PDT; pfam00800 446471002506 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446471002507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002508 Ferredoxin [Energy production and conversion]; Region: COG1146 446471002509 4Fe-4S binding domain; Region: Fer4; cl02805 446471002510 LL-diaminopimelate aminotransferase; Region: DapC_direct; TIGR03540 446471002511 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446471002512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471002513 homodimer interface [polypeptide binding]; other site 446471002514 catalytic residue [active] 446471002515 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 446471002516 dimer interface [polypeptide binding]; other site 446471002517 Citrate synthase; Region: Citrate_synt; pfam00285 446471002518 active site 446471002519 citrylCoA binding site [chemical binding]; other site 446471002520 NADH binding [chemical binding]; other site 446471002521 cationic pore residues; other site 446471002522 oxalacetate/citrate binding site [chemical binding]; other site 446471002523 coenzyme A binding site [chemical binding]; other site 446471002524 catalytic triad [active] 446471002525 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 446471002526 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 446471002527 putative trimer interface [polypeptide binding]; other site 446471002528 putative CoA binding site [chemical binding]; other site 446471002529 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 446471002530 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 446471002531 metal binding site [ion binding]; metal-binding site 446471002532 putative dimer interface [polypeptide binding]; other site 446471002533 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 446471002534 dihydropteroate synthase; Region: DHPS; TIGR01496 446471002535 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 446471002536 substrate binding pocket [chemical binding]; other site 446471002537 dimer interface [polypeptide binding]; other site 446471002538 inhibitor binding site; inhibition site 446471002539 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 446471002540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471002541 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 446471002542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471002543 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446471002544 DNA binding residues [nucleotide binding] 446471002545 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 446471002546 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 446471002547 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 446471002548 active site 446471002549 HIGH motif; other site 446471002550 dimer interface [polypeptide binding]; other site 446471002551 KMSKS motif; other site 446471002552 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471002553 hypothetical protein; Provisional; Region: PRK13679 446471002554 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 446471002555 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 446471002556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002557 domain; Region: Succ_DH_flav_C; pfam02910 446471002558 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 446471002559 putative Iron-sulfur protein interface [polypeptide binding]; other site 446471002560 putative proximal heme binding site [chemical binding]; other site 446471002561 putative SdhC-like subunit interface [polypeptide binding]; other site 446471002562 putative distal heme binding site [chemical binding]; other site 446471002563 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 446471002564 putative Iron-sulfur protein interface [polypeptide binding]; other site 446471002565 putative proximal heme binding site [chemical binding]; other site 446471002566 putative SdhD-like interface [polypeptide binding]; other site 446471002567 putative distal heme binding site [chemical binding]; other site 446471002568 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 446471002569 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471002570 active site 446471002571 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446471002572 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 446471002573 metal binding site [ion binding]; metal-binding site 446471002574 putative dimer interface [polypeptide binding]; other site 446471002575 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 446471002576 ligand binding site [chemical binding]; other site 446471002577 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 446471002578 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 446471002579 Walker A/P-loop; other site 446471002580 ATP binding site [chemical binding]; other site 446471002581 Q-loop/lid; other site 446471002582 ABC transporter signature motif; other site 446471002583 Walker B; other site 446471002584 D-loop; other site 446471002585 H-loop/switch region; other site 446471002586 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 446471002587 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446471002588 TM-ABC transporter signature motif; other site 446471002589 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 446471002590 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446471002591 TM-ABC transporter signature motif; other site 446471002592 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 446471002593 active site 446471002594 catalytic motif [active] 446471002595 Zn binding site [ion binding]; other site 446471002596 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 446471002597 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446471002598 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446471002599 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 446471002600 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446471002601 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446471002602 active site 446471002603 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 446471002604 intersubunit interface [polypeptide binding]; other site 446471002605 active site 446471002606 catalytic residue [active] 446471002607 Protein of unknown function (DUF402); Region: DUF402; cl00979 446471002608 Protein of unknown function (DUF402); Region: DUF402; cl00979 446471002609 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 446471002610 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 446471002611 active site 446471002612 substrate binding site [chemical binding]; other site 446471002613 metal binding site [ion binding]; metal-binding site 446471002614 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 446471002615 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 446471002616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002618 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446471002619 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446471002620 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446471002621 substrate binding site [chemical binding]; other site 446471002622 ATP binding site [chemical binding]; other site 446471002623 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446471002624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471002625 H+ Antiporter protein; Region: 2A0121; TIGR00900 446471002626 putative substrate translocation pore; other site 446471002627 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 446471002628 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446471002629 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446471002630 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 446471002631 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446471002632 carboxyltransferase (CT) interaction site; other site 446471002633 biotinylation site [posttranslational modification]; other site 446471002634 Maf-like protein; Region: Maf; pfam02545 446471002635 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 446471002636 active site 446471002637 dimer interface [polypeptide binding]; other site 446471002638 Membrane transport protein; Region: Mem_trans; cl09117 446471002639 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446471002640 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 446471002641 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 446471002642 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 446471002643 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 446471002644 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 446471002645 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 446471002646 cyclase homology domain; Region: CHD; cd07302 446471002647 nucleotidyl binding site; other site 446471002648 metal binding site [ion binding]; metal-binding site 446471002649 dimer interface [polypeptide binding]; other site 446471002650 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 446471002651 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446471002652 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446471002653 aminotransferase; Validated; Region: PRK07777 446471002654 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446471002655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471002656 homodimer interface [polypeptide binding]; other site 446471002657 catalytic residue [active] 446471002658 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 446471002659 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 446471002660 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 446471002661 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 446471002662 ATP binding site [chemical binding]; other site 446471002663 Walker A motif; other site 446471002664 hexamer interface [polypeptide binding]; other site 446471002665 Walker B motif; other site 446471002666 peptide chain release factor 2; Validated; Region: prfB; PRK00578 446471002667 RF-1 domain; Region: RF-1; cl02875 446471002668 RF-1 domain; Region: RF-1; cl02875 446471002669 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 446471002670 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002671 Walker A/P-loop; other site 446471002672 ATP binding site [chemical binding]; other site 446471002673 Q-loop/lid; other site 446471002674 ABC transporter signature motif; other site 446471002675 Walker B; other site 446471002676 D-loop; other site 446471002677 H-loop/switch region; other site 446471002678 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 446471002679 FtsX-like permease family; Region: FtsX; pfam02687 446471002680 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 446471002681 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 446471002682 Peptidase family M23; Region: Peptidase_M23; pfam01551 446471002683 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 446471002684 SmpB-tmRNA interface; other site 446471002685 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 446471002686 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 446471002687 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 446471002688 Ligand binding site [chemical binding]; other site 446471002689 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446471002690 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446471002691 active site 446471002692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471002693 non-specific DNA interactions [nucleotide binding]; other site 446471002694 DNA binding site [nucleotide binding] 446471002695 sequence specific DNA binding site [nucleotide binding]; other site 446471002696 putative cAMP binding site [chemical binding]; other site 446471002697 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446471002698 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471002699 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471002700 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446471002701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002702 putative PBP binding loops; other site 446471002703 dimer interface [polypeptide binding]; other site 446471002704 ABC-ATPase subunit interface; other site 446471002705 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471002706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002707 dimer interface [polypeptide binding]; other site 446471002708 conserved gate region; other site 446471002709 putative PBP binding loops; other site 446471002710 ABC-ATPase subunit interface; other site 446471002711 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446471002712 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 446471002713 active site 446471002714 trimer interface [polypeptide binding]; other site 446471002715 allosteric site; other site 446471002716 active site lid [active] 446471002717 hexamer (dimer of trimers) interface [polypeptide binding]; other site 446471002718 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 446471002719 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446471002720 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471002721 ATP binding site [chemical binding]; other site 446471002722 putative Mg++ binding site [ion binding]; other site 446471002723 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 446471002724 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 446471002725 active site 446471002726 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 446471002727 Putative carbohydrate binding domain; Region: CBM_X; cl05621 446471002728 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 446471002729 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 446471002730 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471002731 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 446471002732 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 446471002733 active site 446471002734 substrate binding site [chemical binding]; other site 446471002735 metal binding site [ion binding]; metal-binding site 446471002736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002738 active site 446471002739 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 446471002740 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 446471002741 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 446471002742 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446471002743 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 446471002744 active site 446471002745 dimerization interface [polypeptide binding]; other site 446471002746 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 446471002747 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 446471002748 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 446471002749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002750 Walker A/P-loop; other site 446471002751 ATP binding site [chemical binding]; other site 446471002752 Q-loop/lid; other site 446471002753 ABC transporter F family; Provisional; Region: PLN03073 446471002754 ABC transporter signature motif; other site 446471002755 Walker B; other site 446471002756 D-loop; other site 446471002757 H-loop/switch region; other site 446471002758 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 446471002759 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002760 Walker A/P-loop; other site 446471002761 ATP binding site [chemical binding]; other site 446471002762 Q-loop/lid; other site 446471002763 ABC transporter signature motif; other site 446471002764 Walker B; other site 446471002765 D-loop; other site 446471002766 H-loop/switch region; other site 446471002767 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446471002768 nudix motif; other site 446471002769 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446471002770 catalytic residues [active] 446471002771 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 446471002772 aromatic arch; other site 446471002773 DCoH dimer interaction site [polypeptide binding]; other site 446471002774 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 446471002775 DCoH tetramer interaction site [polypeptide binding]; other site 446471002776 substrate binding site [chemical binding]; other site 446471002777 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446471002778 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 446471002779 catalytic triad [active] 446471002780 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 446471002781 active site 446471002782 substrate binding site [chemical binding]; other site 446471002783 ATP binding site [chemical binding]; other site 446471002784 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 446471002785 oligomerisation interface [polypeptide binding]; other site 446471002786 mobile loop; other site 446471002787 roof hairpin; other site 446471002788 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471002789 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471002790 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002791 Walker A/P-loop; other site 446471002792 ATP binding site [chemical binding]; other site 446471002793 Q-loop/lid; other site 446471002794 ABC transporter signature motif; other site 446471002795 Walker B; other site 446471002796 D-loop; other site 446471002797 H-loop/switch region; other site 446471002798 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471002799 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471002800 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 446471002801 Walker A/P-loop; other site 446471002802 ATP binding site [chemical binding]; other site 446471002803 Q-loop/lid; other site 446471002804 ABC transporter signature motif; other site 446471002805 Walker B; other site 446471002806 D-loop; other site 446471002807 H-loop/switch region; other site 446471002808 Protein of unknown function (DUF454); Region: DUF454; cl01063 446471002809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471002810 Protein of unknown function, DUF485; Region: DUF485; cl01231 446471002811 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 446471002812 Sodium:solute symporter family; Region: SSF; cl00456 446471002813 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 446471002814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471002815 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446471002816 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 446471002817 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 446471002818 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 446471002819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446471002820 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446471002821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002822 Walker A/P-loop; other site 446471002823 ATP binding site [chemical binding]; other site 446471002824 Q-loop/lid; other site 446471002825 ABC transporter signature motif; other site 446471002826 Walker B; other site 446471002827 D-loop; other site 446471002828 H-loop/switch region; other site 446471002829 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 446471002830 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 446471002831 putative active site [active] 446471002832 putative substrate binding site [chemical binding]; other site 446471002833 catalytic site [active] 446471002834 dimer interface [polypeptide binding]; other site 446471002835 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 446471002836 G1 box; other site 446471002837 GTP/Mg2+ binding site [chemical binding]; other site 446471002838 Switch I region; other site 446471002839 G2 box; other site 446471002840 Switch II region; other site 446471002841 G3 box; other site 446471002842 G4 box; other site 446471002843 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 446471002844 G1 box; other site 446471002845 GTP/Mg2+ binding site [chemical binding]; other site 446471002846 Switch I region; other site 446471002847 G2 box; other site 446471002848 Switch II region; other site 446471002849 G3 box; other site 446471002850 G4 box; other site 446471002851 G5 box; other site 446471002852 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446471002853 dimer interface [polypeptide binding]; other site 446471002854 ssDNA binding site [nucleotide binding]; other site 446471002855 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446471002856 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 446471002857 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471002858 Walker A/P-loop; other site 446471002859 ATP binding site [chemical binding]; other site 446471002860 Q-loop/lid; other site 446471002861 ABC transporter signature motif; other site 446471002862 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 446471002863 ABC transporter; Region: ABC_tran_2; pfam12848 446471002864 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 446471002865 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 446471002866 G1 box; other site 446471002867 GTP/Mg2+ binding site [chemical binding]; other site 446471002868 Switch I region; other site 446471002869 G2 box; other site 446471002870 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 446471002871 G1 box; other site 446471002872 GTP/Mg2+ binding site [chemical binding]; other site 446471002873 Switch I region; other site 446471002874 G2 box; other site 446471002875 Switch II region; other site 446471002876 G3 box; other site 446471002877 G4 box; other site 446471002878 G5 box; other site 446471002879 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 446471002880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446471002881 DNA-binding site [nucleotide binding]; DNA binding site 446471002882 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446471002883 active site 446471002884 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446471002885 DNA binding site [nucleotide binding] 446471002886 Int/Topo IB signature motif; other site 446471002887 active site 446471002888 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 446471002889 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 446471002890 active site 446471002891 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 446471002892 catalytic triad [active] 446471002893 dimer interface [polypeptide binding]; other site 446471002894 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 446471002895 apolar tunnel; other site 446471002896 heme binding site [chemical binding]; other site 446471002897 dimerization interface [polypeptide binding]; other site 446471002898 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 446471002899 active site turn [active] 446471002900 phosphorylation site [posttranslational modification] 446471002901 Mechanosensitive ion channel; Region: MS_channel; pfam00924 446471002902 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 446471002903 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 446471002904 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 446471002905 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 446471002906 Zn binding site [ion binding]; other site 446471002907 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 446471002908 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 446471002909 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 446471002910 active site 446471002911 Zn binding site [ion binding]; other site 446471002912 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 446471002913 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 446471002914 catalytic residue [active] 446471002915 H2TH interface [polypeptide binding]; other site 446471002916 putative catalytic residues [active] 446471002917 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 446471002918 DNA binding site [nucleotide binding] 446471002919 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446471002920 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14810 446471002921 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 446471002922 active site 446471002923 DNA binding site [nucleotide binding] 446471002924 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446471002925 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 446471002926 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 446471002927 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 446471002928 trimer interface [polypeptide binding]; other site 446471002929 active site 446471002930 substrate binding site [chemical binding]; other site 446471002931 CoA binding site [chemical binding]; other site 446471002932 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446471002933 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446471002934 dimer interface [polypeptide binding]; other site 446471002935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471002936 catalytic residue [active] 446471002937 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 446471002938 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446471002939 NAD(P) binding site [chemical binding]; other site 446471002940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471002941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446471002942 putative substrate translocation pore; other site 446471002943 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446471002944 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446471002945 trigger factor; Provisional; Region: tig; PRK01490 446471002946 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 446471002947 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 446471002948 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446471002949 oligomer interface [polypeptide binding]; other site 446471002950 active site residues [active] 446471002951 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446471002952 oligomer interface [polypeptide binding]; other site 446471002953 active site residues [active] 446471002954 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 446471002955 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 446471002956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471002957 Walker A motif; other site 446471002958 ATP binding site [chemical binding]; other site 446471002959 Walker B motif; other site 446471002960 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 446471002961 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446471002962 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 446471002963 Chorismate mutase type II; Region: CM_2; cl00693 446471002964 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 446471002965 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471002966 active site 446471002967 HIGH motif; other site 446471002968 nucleotide binding site [chemical binding]; other site 446471002969 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471002970 active site 446471002971 KMSKS motif; other site 446471002972 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 446471002973 tRNA binding surface [nucleotide binding]; other site 446471002974 anticodon binding site; other site 446471002975 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446471002976 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446471002977 substrate binding pocket [chemical binding]; other site 446471002978 membrane-bound complex binding site; other site 446471002979 hinge residues; other site 446471002980 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446471002981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471002982 dimer interface [polypeptide binding]; other site 446471002983 conserved gate region; other site 446471002984 putative PBP binding loops; other site 446471002985 ABC-ATPase subunit interface; other site 446471002986 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446471002987 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 446471002988 Walker A/P-loop; other site 446471002989 ATP binding site [chemical binding]; other site 446471002990 Q-loop/lid; other site 446471002991 ABC transporter signature motif; other site 446471002992 Walker B; other site 446471002993 D-loop; other site 446471002994 H-loop/switch region; other site 446471002995 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 446471002996 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446471002997 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 446471002998 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 446471002999 CCC1-related family of proteins; Region: CCC1_like; cl00278 446471003000 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446471003001 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471003002 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446471003003 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 446471003004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471003005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446471003006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471003007 putative PBP binding loops; other site 446471003008 ABC-ATPase subunit interface; other site 446471003009 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471003010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471003011 dimer interface [polypeptide binding]; other site 446471003012 conserved gate region; other site 446471003013 putative PBP binding loops; other site 446471003014 ABC-ATPase subunit interface; other site 446471003015 uncharacterized HhH-GPD family protein; Region: TIGR03252 446471003016 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446471003017 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 446471003018 catalytic residues [active] 446471003019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471003020 non-specific DNA binding site [nucleotide binding]; other site 446471003021 salt bridge; other site 446471003022 sequence-specific DNA binding site [nucleotide binding]; other site 446471003023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471003024 NAD(P) binding site [chemical binding]; other site 446471003025 active site 446471003026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471003027 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 446471003028 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446471003029 HIGH motif; other site 446471003030 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446471003031 active site 446471003032 KMSKS motif; other site 446471003033 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 446471003034 tRNA binding surface [nucleotide binding]; other site 446471003035 anticodon binding site; other site 446471003036 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 446471003037 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 446471003038 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446471003039 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446471003040 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446471003041 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 446471003042 Cellulose binding domain; Region: CBM_2; cl02709 446471003043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471003044 DNA binding site [nucleotide binding] 446471003045 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446471003046 ligand binding site [chemical binding]; other site 446471003047 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446471003048 ligand binding site [chemical binding]; other site 446471003049 dimerization interface [polypeptide binding]; other site 446471003050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446471003051 putative active site [active] 446471003052 heme pocket [chemical binding]; other site 446471003053 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 446471003054 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 446471003055 Cellulose binding domain; Region: CBM_2; cl02709 446471003056 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 446471003057 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 446471003058 DAK2 domain; Region: Dak2; cl03685 446471003059 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 446471003060 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 446471003061 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 446471003062 active site 446471003063 multimer interface [polypeptide binding]; other site 446471003064 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 446471003065 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 446471003066 Walker A/P-loop; other site 446471003067 ATP binding site [chemical binding]; other site 446471003068 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 446471003069 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 446471003070 ABC transporter signature motif; other site 446471003071 Walker B; other site 446471003072 D-loop; other site 446471003073 H-loop/switch region; other site 446471003074 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 446471003075 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 446471003076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003077 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 446471003078 Nitrogen regulatory protein P-II; Region: P-II; cl00412 446471003079 PII uridylyl-transferase; Provisional; Region: PRK03381 446471003080 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446471003081 metal binding triad; other site 446471003082 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446471003083 signal recognition particle protein; Provisional; Region: PRK10867 446471003084 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 446471003085 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 446471003086 P loop; other site 446471003087 GTP binding site [chemical binding]; other site 446471003088 Signal peptide binding domain; Region: SRP_SPB; pfam02978 446471003089 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446471003090 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446471003091 active site 446471003092 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 446471003093 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 446471003094 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 446471003095 RimM N-terminal domain; Region: RimM; pfam01782 446471003096 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 446471003097 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 446471003098 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 446471003099 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446471003100 Catalytic site [active] 446471003101 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 446471003102 RNA/DNA hybrid binding site [nucleotide binding]; other site 446471003103 active site 446471003104 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 446471003105 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 446471003106 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 446471003107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003108 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 446471003109 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 446471003110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446471003111 DNA binding site [nucleotide binding] 446471003112 Int/Topo IB signature motif; other site 446471003113 active site 446471003114 Peptidase family M23; Region: Peptidase_M23; pfam01551 446471003115 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 446471003116 rRNA interaction site [nucleotide binding]; other site 446471003117 S8 interaction site; other site 446471003118 putative laminin-1 binding site; other site 446471003119 elongation factor Ts; Provisional; Region: tsf; PRK09377 446471003120 Elongation factor TS; Region: EF_TS; pfam00889 446471003121 Elongation factor TS; Region: EF_TS; pfam00889 446471003122 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 446471003123 putative nucleotide binding site [chemical binding]; other site 446471003124 uridine monophosphate binding site [chemical binding]; other site 446471003125 homohexameric interface [polypeptide binding]; other site 446471003126 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 446471003127 hinge region; other site 446471003128 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 446471003129 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 446471003130 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446471003131 FeS/SAM binding site; other site 446471003132 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 446471003133 DivIVA domain; Region: DivI1A_domain; TIGR03544 446471003134 Protein of unknown function, DUF624; Region: DUF624; cl02369 446471003135 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471003136 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471003137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471003138 dimer interface [polypeptide binding]; other site 446471003139 conserved gate region; other site 446471003140 ABC-ATPase subunit interface; other site 446471003141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446471003142 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471003143 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471003144 DNA binding site [nucleotide binding] 446471003145 domain linker motif; other site 446471003146 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446471003147 dimerization interface [polypeptide binding]; other site 446471003148 ligand binding site [chemical binding]; other site 446471003149 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446471003150 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 446471003151 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446471003152 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 446471003153 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 446471003154 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 446471003155 active site 446471003156 homotrimer interface [polypeptide binding]; other site 446471003157 catalytic site [active] 446471003158 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 446471003159 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446471003160 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 446471003161 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 446471003162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471003163 Bacterial SH3 domain; Region: SH3_3; cl02551 446471003164 Domain of unknown function DUF222; Region: DUF222; pfam02720 446471003165 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446471003166 active site 446471003167 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 446471003168 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 446471003169 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 446471003170 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 446471003171 active site 446471003172 RIP metalloprotease RseP; Region: TIGR00054 446471003173 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 446471003174 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 446471003175 putative substrate binding region [chemical binding]; other site 446471003176 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 446471003177 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 446471003178 Predicted acetyltransferase [General function prediction only]; Region: COG3393 446471003179 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471003180 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 446471003181 active site 446471003182 nucleotide-binding site [chemical binding]; other site 446471003183 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 446471003184 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 446471003185 putative DNA binding site [nucleotide binding]; other site 446471003186 catalytic residue [active] 446471003187 putative H2TH interface [polypeptide binding]; other site 446471003188 putative catalytic residues [active] 446471003189 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446471003190 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446471003191 prolyl-tRNA synthetase; Provisional; Region: PRK09194 446471003192 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 446471003193 dimer interface [polypeptide binding]; other site 446471003194 motif 1; other site 446471003195 active site 446471003196 motif 2; other site 446471003197 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 446471003198 putative deacylase active site [active] 446471003199 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 446471003200 active site 446471003201 motif 3; other site 446471003202 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 446471003203 anticodon binding site; other site 446471003204 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 446471003205 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 446471003206 Sm1 motif; other site 446471003207 D3 - B interaction site; other site 446471003208 D1 - D2 interaction site; other site 446471003209 Hfq - Hfq interaction site; other site 446471003210 RNA binding pocket [nucleotide binding]; other site 446471003211 Sm2 motif; other site 446471003212 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 446471003213 NusA N-terminal domain; Region: NusA_N; pfam08529 446471003214 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 446471003215 RNA binding site [nucleotide binding]; other site 446471003216 homodimer interface [polypeptide binding]; other site 446471003217 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 446471003218 G-X-X-G motif; other site 446471003219 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 446471003220 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446471003221 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446471003222 translation initiation factor IF-2; Region: IF-2; TIGR00487 446471003223 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 446471003224 G1 box; other site 446471003225 putative GEF interaction site [polypeptide binding]; other site 446471003226 GTP/Mg2+ binding site [chemical binding]; other site 446471003227 Switch I region; other site 446471003228 G2 box; other site 446471003229 G3 box; other site 446471003230 Switch II region; other site 446471003231 G4 box; other site 446471003232 G5 box; other site 446471003233 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 446471003234 Translation-initiation factor 2; Region: IF-2; pfam11987 446471003235 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 446471003236 Ribosome-binding factor A; Region: RBFA; cl00542 446471003237 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 446471003238 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 446471003239 RNA binding site [nucleotide binding]; other site 446471003240 active site 446471003241 Excalibur calcium-binding domain; Region: Excalibur; cl05460 446471003242 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 446471003243 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 446471003244 active site 446471003245 Riboflavin kinase; Region: Flavokinase; cl03312 446471003246 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 446471003247 16S/18S rRNA binding site [nucleotide binding]; other site 446471003248 S13e-L30e interaction site [polypeptide binding]; other site 446471003249 25S rRNA binding site [nucleotide binding]; other site 446471003250 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 446471003251 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 446471003252 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 446471003253 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 446471003254 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 446471003255 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 446471003256 putative nucleic acid binding region [nucleotide binding]; other site 446471003257 G-X-X-G motif; other site 446471003258 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 446471003259 RNA binding site [nucleotide binding]; other site 446471003260 domain interface; other site 446471003261 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446471003262 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 446471003263 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446471003264 dihydrodipicolinate reductase; Provisional; Region: PRK00048 446471003265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471003266 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 446471003267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471003268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446471003269 putative substrate translocation pore; other site 446471003270 HipA N-terminal domain; Region: couple_hipA; TIGR03071 446471003271 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 446471003272 HipA-like N-terminal domain; Region: HipA_N; pfam07805 446471003273 HipA-like C-terminal domain; Region: HipA_C; pfam07804 446471003274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471003275 non-specific DNA binding site [nucleotide binding]; other site 446471003276 salt bridge; other site 446471003277 sequence-specific DNA binding site [nucleotide binding]; other site 446471003278 AzlC protein; Region: AzlC; cl00570 446471003279 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446471003280 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 446471003281 tetramerization interface [polypeptide binding]; other site 446471003282 NAD(P) binding site [chemical binding]; other site 446471003283 catalytic residues [active] 446471003284 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 446471003285 dihydrodipicolinate synthase; Region: dapA; TIGR00674 446471003286 dimer interface [polypeptide binding]; other site 446471003287 active site 446471003288 catalytic residue [active] 446471003289 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 446471003290 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446471003291 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 446471003292 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003293 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 446471003294 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 446471003295 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 446471003296 putative active site [active] 446471003297 putative metal binding site [ion binding]; other site 446471003298 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 446471003299 Competence-damaged protein; Region: CinA; cl00666 446471003300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471003301 non-specific DNA binding site [nucleotide binding]; other site 446471003302 salt bridge; other site 446471003303 sequence-specific DNA binding site [nucleotide binding]; other site 446471003304 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 446471003305 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 446471003306 putative DNA binding site [nucleotide binding]; other site 446471003307 catalytic residue [active] 446471003308 putative H2TH interface [polypeptide binding]; other site 446471003309 putative catalytic residues [active] 446471003310 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446471003311 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471003312 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 446471003313 ATP binding site [chemical binding]; other site 446471003314 putative Mg++ binding site [ion binding]; other site 446471003315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471003316 nucleotide binding region [chemical binding]; other site 446471003317 ATP-binding site [chemical binding]; other site 446471003318 DEAD/H associated; Region: DEAD_assoc; pfam08494 446471003319 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 446471003320 recombinase A; Provisional; Region: recA; PRK09354 446471003321 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 446471003322 hexamer interface [polypeptide binding]; other site 446471003323 Walker A motif; other site 446471003324 ATP binding site [chemical binding]; other site 446471003325 Walker B motif; other site 446471003326 RecX family; Region: RecX; cl00936 446471003327 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446471003328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471003329 dimer interface [polypeptide binding]; other site 446471003330 conserved gate region; other site 446471003331 putative PBP binding loops; other site 446471003332 ABC-ATPase subunit interface; other site 446471003333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471003334 dimer interface [polypeptide binding]; other site 446471003335 conserved gate region; other site 446471003336 putative PBP binding loops; other site 446471003337 ABC-ATPase subunit interface; other site 446471003338 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446471003339 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446471003340 substrate binding pocket [chemical binding]; other site 446471003341 membrane-bound complex binding site; other site 446471003342 hinge residues; other site 446471003343 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446471003344 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 446471003345 Walker A/P-loop; other site 446471003346 ATP binding site [chemical binding]; other site 446471003347 Q-loop/lid; other site 446471003348 ABC transporter signature motif; other site 446471003349 Walker B; other site 446471003350 D-loop; other site 446471003351 H-loop/switch region; other site 446471003352 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 446471003353 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 446471003354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446471003355 FeS/SAM binding site; other site 446471003356 IPP transferase; Region: IPPT; cl00403 446471003357 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 446471003358 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 446471003359 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 446471003360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446471003361 S-adenosylmethionine binding site [chemical binding]; other site 446471003362 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 446471003363 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 446471003364 G1 box; other site 446471003365 GTP/Mg2+ binding site [chemical binding]; other site 446471003366 Switch I region; other site 446471003367 G2 box; other site 446471003368 G3 box; other site 446471003369 Switch II region; other site 446471003370 G4 box; other site 446471003371 G5 box; other site 446471003372 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 446471003373 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003374 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003375 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 446471003376 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 446471003377 NAD binding site [chemical binding]; other site 446471003378 dimer interface [polypeptide binding]; other site 446471003379 substrate binding site [chemical binding]; other site 446471003380 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446471003381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471003382 LexA repressor; Validated; Region: PRK00215 446471003383 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 446471003384 Catalytic site [active] 446471003385 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 446471003386 putative peptidoglycan binding site; other site 446471003387 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 446471003388 ATP cone domain; Region: ATP-cone; pfam03477 446471003389 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 446471003390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471003391 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 446471003392 L-serine binding site [chemical binding]; other site 446471003393 ACT domain interface; other site 446471003394 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446471003395 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446471003396 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 446471003397 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 446471003398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446471003399 dimer interface [polypeptide binding]; other site 446471003400 phosphorylation site [posttranslational modification] 446471003401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471003402 ATP binding site [chemical binding]; other site 446471003403 Mg2+ binding site [ion binding]; other site 446471003404 G-X-G motif; other site 446471003405 Response regulator receiver domain; Region: Response_reg; pfam00072 446471003406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471003407 active site 446471003408 phosphorylation site [posttranslational modification] 446471003409 intermolecular recognition site; other site 446471003410 dimerization interface [polypeptide binding]; other site 446471003411 PAC2 family; Region: PAC2; cl00847 446471003412 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 446471003413 DNA-binding site [nucleotide binding]; DNA binding site 446471003414 RNA-binding motif; other site 446471003415 DNA polymerase IV; Validated; Region: PRK03858 446471003416 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 446471003417 active site 446471003418 DNA binding site [nucleotide binding] 446471003419 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 446471003420 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 446471003421 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446471003422 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446471003423 MoxR-like ATPases [General function prediction only]; Region: COG0714 446471003424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471003425 Walker A motif; other site 446471003426 ATP binding site [chemical binding]; other site 446471003427 Walker B motif; other site 446471003428 arginine finger; other site 446471003429 MraZ protein; Region: MraZ; pfam02381 446471003430 cell division protein MraZ; Reviewed; Region: PRK00326 446471003431 MraZ protein; Region: MraZ; pfam02381 446471003432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471003433 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 446471003434 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 446471003435 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446471003436 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 446471003437 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 446471003438 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446471003439 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446471003440 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 446471003441 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446471003442 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446471003443 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 446471003444 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 446471003445 Mg++ binding site [ion binding]; other site 446471003446 putative catalytic motif [active] 446471003447 putative substrate binding site [chemical binding]; other site 446471003448 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 446471003449 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446471003450 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 446471003451 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 446471003452 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 446471003453 active site 446471003454 homodimer interface [polypeptide binding]; other site 446471003455 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 446471003456 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446471003457 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446471003458 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 446471003459 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 446471003460 Cell division protein FtsQ; Region: FtsQ; pfam03799 446471003461 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 446471003462 nucleotide binding site [chemical binding]; other site 446471003463 SulA interaction site; other site 446471003464 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 446471003465 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 446471003466 Protein of unknown function (DUF552); Region: DUF552; cl00775 446471003467 YGGT family; Region: YGGT; cl00508 446471003468 DivIVA protein; Region: DivIVA; pfam05103 446471003469 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 446471003470 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 446471003471 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 446471003472 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 446471003473 active site 446471003474 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471003475 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 446471003476 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 446471003477 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 446471003478 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 446471003479 generic binding surface II; other site 446471003480 generic binding surface I; other site 446471003481 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 446471003482 nudix motif; other site 446471003483 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 446471003484 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 446471003485 active site 446471003486 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446471003487 RNA binding surface [nucleotide binding]; other site 446471003488 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 446471003489 histidinol dehydrogenase; Region: hisD; TIGR00069 446471003490 NAD binding site [chemical binding]; other site 446471003491 dimerization interface [polypeptide binding]; other site 446471003492 product binding site; other site 446471003493 substrate binding site [chemical binding]; other site 446471003494 zinc binding site [ion binding]; other site 446471003495 catalytic residues [active] 446471003496 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 446471003497 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003498 active site 446471003499 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446471003500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471003501 ATP binding site [chemical binding]; other site 446471003502 putative Mg++ binding site [ion binding]; other site 446471003503 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471003504 nucleotide binding region [chemical binding]; other site 446471003505 ATP-binding site [chemical binding]; other site 446471003506 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446471003507 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 446471003508 iron-sulfur cluster [ion binding]; other site 446471003509 [2Fe-2S] cluster binding site [ion binding]; other site 446471003510 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 446471003511 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446471003512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471003513 homodimer interface [polypeptide binding]; other site 446471003514 catalytic residue [active] 446471003515 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 446471003516 putative active site pocket [active] 446471003517 4-fold oligomerization interface [polypeptide binding]; other site 446471003518 metal binding residues [ion binding]; metal-binding site 446471003519 3-fold/trimer interface [polypeptide binding]; other site 446471003520 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 446471003521 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 446471003522 putative active site [active] 446471003523 oxyanion strand; other site 446471003524 catalytic triad [active] 446471003525 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 446471003526 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 446471003527 catalytic residues [active] 446471003528 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 446471003529 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 446471003530 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 446471003531 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 446471003532 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 446471003533 ribosomal protein L20; Region: rpl20; CHL00068 446471003534 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 446471003535 23S rRNA binding site [nucleotide binding]; other site 446471003536 L21 binding site [polypeptide binding]; other site 446471003537 L13 binding site [polypeptide binding]; other site 446471003538 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446471003539 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 446471003540 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 446471003541 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 446471003542 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 446471003543 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 446471003544 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 446471003545 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 446471003546 dimer interface [polypeptide binding]; other site 446471003547 motif 1; other site 446471003548 active site 446471003549 motif 2; other site 446471003550 motif 3; other site 446471003551 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 446471003552 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 446471003553 putative tRNA-binding site [nucleotide binding]; other site 446471003554 B3/4 domain; Region: B3_4; cl11458 446471003555 tRNA synthetase B5 domain; Region: B5; cl08394 446471003556 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 446471003557 dimer interface [polypeptide binding]; other site 446471003558 motif 1; other site 446471003559 motif 3; other site 446471003560 motif 2; other site 446471003561 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 446471003562 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 446471003563 substrate binding site [chemical binding]; other site 446471003564 active site 446471003565 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 446471003566 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446471003567 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 446471003568 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 446471003569 NADP binding site [chemical binding]; other site 446471003570 dimer interface [polypeptide binding]; other site 446471003571 Domain of unknown function (DUF385); Region: DUF385; cl04387 446471003572 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 446471003573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471003574 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 446471003575 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 446471003576 heterotetramer interface [polypeptide binding]; other site 446471003577 active site pocket [active] 446471003578 cleavage site 446471003579 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 446471003580 feedback inhibition sensing region; other site 446471003581 homohexameric interface [polypeptide binding]; other site 446471003582 nucleotide binding site [chemical binding]; other site 446471003583 N-acetyl-L-glutamate binding site [chemical binding]; other site 446471003584 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 446471003585 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446471003586 inhibitor-cofactor binding pocket; inhibition site 446471003587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471003588 catalytic residue [active] 446471003589 ornithine carbamoyltransferase; Provisional; Region: PRK00779 446471003590 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446471003591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471003592 arginine repressor; Provisional; Region: PRK03341 446471003593 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 446471003594 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 446471003595 argininosuccinate lyase; Provisional; Region: PRK00855 446471003596 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 446471003597 active sites [active] 446471003598 tetramer interface [polypeptide binding]; other site 446471003599 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003600 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 446471003601 active site 446471003602 DNA binding site [nucleotide binding] 446471003603 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 446471003604 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 446471003605 active site 446471003606 HIGH motif; other site 446471003607 dimer interface [polypeptide binding]; other site 446471003608 KMSKS motif; other site 446471003609 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 446471003610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446471003611 active site 446471003612 motif I; other site 446471003613 motif II; other site 446471003614 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 446471003615 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 446471003616 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 446471003617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446471003618 S-adenosylmethionine binding site [chemical binding]; other site 446471003619 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 446471003620 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 446471003621 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003622 Walker A/P-loop; other site 446471003623 ATP binding site [chemical binding]; other site 446471003624 Q-loop/lid; other site 446471003625 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003626 ABC transporter signature motif; other site 446471003627 Walker B; other site 446471003628 D-loop; other site 446471003629 H-loop/switch region; other site 446471003630 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 446471003631 Thiamine pyrophosphokinase; Region: TPK; cl09135 446471003632 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 446471003633 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 446471003634 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 446471003635 CTP synthetase; Validated; Region: pyrG; PRK05380 446471003636 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 446471003637 Catalytic site [active] 446471003638 active site 446471003639 UTP binding site [chemical binding]; other site 446471003640 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 446471003641 active site 446471003642 putative oxyanion hole; other site 446471003643 catalytic triad [active] 446471003644 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446471003645 dimer interface [polypeptide binding]; other site 446471003646 ADP-ribose binding site [chemical binding]; other site 446471003647 active site 446471003648 nudix motif; other site 446471003649 metal binding site [ion binding]; metal-binding site 446471003650 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471003651 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471003652 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446471003653 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003654 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446471003655 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003656 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446471003657 Walker A/P-loop; other site 446471003658 ATP binding site [chemical binding]; other site 446471003659 Q-loop/lid; other site 446471003660 ABC transporter signature motif; other site 446471003661 Walker B; other site 446471003662 D-loop; other site 446471003663 H-loop/switch region; other site 446471003664 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 446471003665 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 446471003666 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446471003667 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446471003668 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446471003669 Walker A/P-loop; other site 446471003670 ATP binding site [chemical binding]; other site 446471003671 Q-loop/lid; other site 446471003672 ABC transporter signature motif; other site 446471003673 Walker B; other site 446471003674 D-loop; other site 446471003675 H-loop/switch region; other site 446471003676 Predicted transcriptional regulator [Transcription]; Region: COG2345 446471003677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446471003678 putative DNA binding site [nucleotide binding]; other site 446471003679 putative Zn2+ binding site [ion binding]; other site 446471003680 FeS assembly protein SufB; Region: sufB; TIGR01980 446471003681 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 446471003682 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 446471003683 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 446471003684 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 446471003685 [2Fe-2S] cluster binding site [ion binding]; other site 446471003686 FeS assembly ATPase SufC; Region: sufC; TIGR01978 446471003687 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 446471003688 Walker A/P-loop; other site 446471003689 ATP binding site [chemical binding]; other site 446471003690 Q-loop/lid; other site 446471003691 ABC transporter signature motif; other site 446471003692 Walker B; other site 446471003693 D-loop; other site 446471003694 H-loop/switch region; other site 446471003695 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 446471003696 Aminotransferase class-V; Region: Aminotran_5; pfam00266 446471003697 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446471003698 catalytic residue [active] 446471003699 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 446471003700 trimerization site [polypeptide binding]; other site 446471003701 active site 446471003702 Domain of unknown function DUF59; Region: DUF59; cl00941 446471003703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 446471003704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471003705 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471003706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471003707 dimer interface [polypeptide binding]; other site 446471003708 conserved gate region; other site 446471003709 ABC-ATPase subunit interface; other site 446471003710 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446471003711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446471003712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471003713 dimer interface [polypeptide binding]; other site 446471003714 putative PBP binding loops; other site 446471003715 ABC-ATPase subunit interface; other site 446471003716 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471003717 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471003718 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446471003719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471003720 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 446471003721 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 446471003722 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446471003723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471003724 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471003725 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471003726 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471003727 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471003728 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 446471003729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471003730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471003731 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446471003732 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446471003733 active site 446471003734 metal binding site [ion binding]; metal-binding site 446471003735 Domain of unknown function DUF20; Region: UPF0118; cl00465 446471003736 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 446471003737 Moco binding site; other site 446471003738 metal coordination site [ion binding]; other site 446471003739 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446471003740 nudix motif; other site 446471003741 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 446471003742 heme-binding site [chemical binding]; other site 446471003743 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 446471003744 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 446471003745 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471003746 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446471003747 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446471003748 FAD binding pocket [chemical binding]; other site 446471003749 FAD binding motif [chemical binding]; other site 446471003750 phosphate binding motif [ion binding]; other site 446471003751 NAD binding pocket [chemical binding]; other site 446471003752 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 446471003753 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446471003754 putative ligand binding residues [chemical binding]; other site 446471003755 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446471003756 ABC-ATPase subunit interface; other site 446471003757 dimer interface [polypeptide binding]; other site 446471003758 putative PBP binding regions; other site 446471003759 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446471003760 ABC-ATPase subunit interface; other site 446471003761 dimer interface [polypeptide binding]; other site 446471003762 putative PBP binding regions; other site 446471003763 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 446471003764 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446471003765 Walker A/P-loop; other site 446471003766 ATP binding site [chemical binding]; other site 446471003767 Q-loop/lid; other site 446471003768 ABC transporter signature motif; other site 446471003769 Walker B; other site 446471003770 D-loop; other site 446471003771 H-loop/switch region; other site 446471003772 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 446471003773 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 446471003774 catalytic residues [active] 446471003775 Transglycosylase; Region: Transgly; cl07896 446471003776 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446471003777 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 446471003778 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 446471003779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 446471003780 PAS fold; Region: PAS_3; pfam08447 446471003781 putative active site [active] 446471003782 heme pocket [chemical binding]; other site 446471003783 ANTAR domain; Region: ANTAR; cl04297 446471003784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471003785 short chain dehydrogenase; Provisional; Region: PRK06701 446471003786 NAD(P) binding site [chemical binding]; other site 446471003787 active site 446471003788 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 446471003789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471003790 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446471003791 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003792 Walker A/P-loop; other site 446471003793 ATP binding site [chemical binding]; other site 446471003794 Q-loop/lid; other site 446471003795 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 446471003796 ABC transporter signature motif; other site 446471003797 Walker B; other site 446471003798 D-loop; other site 446471003799 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 446471003800 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 446471003801 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 446471003802 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 446471003803 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 446471003804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471003805 NAD(P) binding site [chemical binding]; other site 446471003806 active site 446471003807 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 446471003808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471003809 NAD(P) binding site [chemical binding]; other site 446471003810 active site 446471003811 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 446471003812 catalytic core [active] 446471003813 phosphoserine phosphatase SerB; Region: serB; TIGR00338 446471003814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446471003815 motif II; other site 446471003816 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 446471003817 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 446471003818 ligand binding site; other site 446471003819 oligomer interface; other site 446471003820 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 446471003821 dimer interface [polypeptide binding]; other site 446471003822 N-terminal domain interface [polypeptide binding]; other site 446471003823 sulfate 1 binding site; other site 446471003824 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 446471003825 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446471003826 VanZ like family; Region: VanZ; cl01971 446471003827 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 446471003828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446471003829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471003830 active site 446471003831 phosphorylation site [posttranslational modification] 446471003832 intermolecular recognition site; other site 446471003833 dimerization interface [polypeptide binding]; other site 446471003834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446471003835 DNA binding site [nucleotide binding] 446471003836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446471003837 dimerization interface [polypeptide binding]; other site 446471003838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446471003839 dimer interface [polypeptide binding]; other site 446471003840 phosphorylation site [posttranslational modification] 446471003841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471003842 ATP binding site [chemical binding]; other site 446471003843 Mg2+ binding site [ion binding]; other site 446471003844 G-X-G motif; other site 446471003845 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446471003846 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003847 Walker A/P-loop; other site 446471003848 ATP binding site [chemical binding]; other site 446471003849 Q-loop/lid; other site 446471003850 ABC transporter signature motif; other site 446471003851 Walker B; other site 446471003852 D-loop; other site 446471003853 H-loop/switch region; other site 446471003854 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 446471003855 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 446471003856 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471003857 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471003858 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471003859 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003860 Walker A/P-loop; other site 446471003861 ATP binding site [chemical binding]; other site 446471003862 Q-loop/lid; other site 446471003863 ABC transporter signature motif; other site 446471003864 Walker B; other site 446471003865 D-loop; other site 446471003866 H-loop/switch region; other site 446471003867 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471003868 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471003869 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 446471003870 Walker A/P-loop; other site 446471003871 ATP binding site [chemical binding]; other site 446471003872 Q-loop/lid; other site 446471003873 ABC transporter signature motif; other site 446471003874 Walker B; other site 446471003875 D-loop; other site 446471003876 H-loop/switch region; other site 446471003877 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 446471003878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471003879 NAD(P) binding site [chemical binding]; other site 446471003880 active site 446471003881 Cupin domain; Region: Cupin_2; cl09118 446471003882 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446471003883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446471003884 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446471003885 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 446471003886 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446471003887 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446471003888 FAD binding pocket [chemical binding]; other site 446471003889 FAD binding motif [chemical binding]; other site 446471003890 phosphate binding motif [ion binding]; other site 446471003891 NAD binding pocket [chemical binding]; other site 446471003892 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 446471003893 putative deacylase active site [active] 446471003894 Y-family of DNA polymerases; Region: PolY; cl12025 446471003895 DNA binding site [nucleotide binding] 446471003896 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 446471003897 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 446471003898 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 446471003899 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 446471003900 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 446471003901 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 446471003902 generic binding surface I; other site 446471003903 generic binding surface II; other site 446471003904 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 446471003905 ATP binding site [chemical binding]; other site 446471003906 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 446471003907 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 446471003908 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 446471003909 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 446471003910 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471003911 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446471003912 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446471003913 Walker A/P-loop; other site 446471003914 ATP binding site [chemical binding]; other site 446471003915 Q-loop/lid; other site 446471003916 ABC transporter signature motif; other site 446471003917 Walker B; other site 446471003918 D-loop; other site 446471003919 H-loop/switch region; other site 446471003920 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446471003921 ABC-ATPase subunit interface; other site 446471003922 dimer interface [polypeptide binding]; other site 446471003923 putative PBP binding regions; other site 446471003924 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446471003925 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446471003926 ABC-ATPase subunit interface; other site 446471003927 dimer interface [polypeptide binding]; other site 446471003928 putative PBP binding regions; other site 446471003929 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 446471003930 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446471003931 intersubunit interface [polypeptide binding]; other site 446471003932 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446471003933 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446471003934 FAD binding pocket [chemical binding]; other site 446471003935 FAD binding motif [chemical binding]; other site 446471003936 phosphate binding motif [ion binding]; other site 446471003937 NAD binding pocket [chemical binding]; other site 446471003938 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 446471003939 dimer interface [polypeptide binding]; other site 446471003940 substrate binding site [chemical binding]; other site 446471003941 ATP binding site [chemical binding]; other site 446471003942 ThiC family; Region: ThiC; cl08031 446471003943 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 446471003944 thiamine phosphate binding site [chemical binding]; other site 446471003945 active site 446471003946 pyrophosphate binding site [ion binding]; other site 446471003947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471003948 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 446471003949 thiS-thiF/thiG interaction site; other site 446471003950 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 446471003951 ThiS interaction site; other site 446471003952 putative active site [active] 446471003953 tetramer interface [polypeptide binding]; other site 446471003954 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 446471003955 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 446471003956 ATP binding site [chemical binding]; other site 446471003957 substrate interface [chemical binding]; other site 446471003958 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471003959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471003960 active site 446471003961 phosphorylation site [posttranslational modification] 446471003962 intermolecular recognition site; other site 446471003963 dimerization interface [polypeptide binding]; other site 446471003964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471003965 DNA binding residues [nucleotide binding] 446471003966 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 446471003967 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 446471003968 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 446471003969 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446471003970 Domain of unknown function DUF20; Region: UPF0118; cl00465 446471003971 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446471003972 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471003973 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446471003974 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471003975 Walker A/P-loop; other site 446471003976 ATP binding site [chemical binding]; other site 446471003977 Q-loop/lid; other site 446471003978 ABC transporter signature motif; other site 446471003979 Walker B; other site 446471003980 D-loop; other site 446471003981 H-loop/switch region; other site 446471003982 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 446471003983 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 446471003984 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 446471003985 active site 446471003986 Zn binding site [ion binding]; other site 446471003987 hypothetical protein; Provisional; Region: PRK07906 446471003988 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 446471003989 putative metal binding site [ion binding]; other site 446471003990 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 446471003991 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446471003992 active site 446471003993 catalytic tetrad [active] 446471003994 Bacitracin resistance protein BacA; Region: BacA; cl00858 446471003995 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471003996 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 446471003997 active site 446471003998 HIGH motif; other site 446471003999 nucleotide binding site [chemical binding]; other site 446471004000 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471004001 active site 446471004002 KMSKS motif; other site 446471004003 PAC2 family; Region: PAC2; cl00847 446471004004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446471004005 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 446471004006 active site 446471004007 motif I; other site 446471004008 motif II; other site 446471004009 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 446471004010 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 446471004011 active site 446471004012 putative substrate binding region [chemical binding]; other site 446471004013 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 446471004014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471004015 proteasome ATPase; Region: pup_AAA; TIGR03689 446471004016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471004017 Walker A motif; other site 446471004018 ATP binding site [chemical binding]; other site 446471004019 Walker B motif; other site 446471004020 arginine finger; other site 446471004021 Pup-ligase protein; Region: Pup_ligase; cl15463 446471004022 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 446471004023 Pup-like protein; Region: Pup; cl05289 446471004024 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 446471004025 active site 446471004026 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 446471004027 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446471004028 active site 446471004029 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 446471004030 Pup-ligase protein; Region: Pup_ligase; cl15463 446471004031 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 446471004032 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 446471004033 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 446471004034 substrate binding site [chemical binding]; other site 446471004035 glutamase interaction surface [polypeptide binding]; other site 446471004036 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471004037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471004038 Walker A/P-loop; other site 446471004039 ATP binding site [chemical binding]; other site 446471004040 Q-loop/lid; other site 446471004041 ABC transporter signature motif; other site 446471004042 Walker B; other site 446471004043 D-loop; other site 446471004044 H-loop/switch region; other site 446471004045 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471004046 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471004047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471004048 Walker A/P-loop; other site 446471004049 ATP binding site [chemical binding]; other site 446471004050 Q-loop/lid; other site 446471004051 ABC transporter signature motif; other site 446471004052 Walker B; other site 446471004053 D-loop; other site 446471004054 H-loop/switch region; other site 446471004055 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 446471004056 anthranilate synthase component I; Provisional; Region: PRK13571 446471004057 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 446471004058 chorismate binding enzyme; Region: Chorismate_bind; cl10555 446471004059 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 446471004060 active site 446471004061 ribulose/triose binding site [chemical binding]; other site 446471004062 phosphate binding site [ion binding]; other site 446471004063 substrate (anthranilate) binding pocket [chemical binding]; other site 446471004064 product (indole) binding pocket [chemical binding]; other site 446471004065 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 446471004066 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 446471004067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471004068 catalytic residue [active] 446471004069 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 446471004070 substrate binding site [chemical binding]; other site 446471004071 active site 446471004072 catalytic residues [active] 446471004073 heterodimer interface [polypeptide binding]; other site 446471004074 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 446471004075 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 446471004076 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 446471004077 active site 446471004078 dimer interface [polypeptide binding]; other site 446471004079 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 446471004080 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 446471004081 active site 446471004082 FMN binding site [chemical binding]; other site 446471004083 substrate binding site [chemical binding]; other site 446471004084 3Fe-4S cluster binding site [ion binding]; other site 446471004085 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 446471004086 domain interface; other site 446471004087 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 446471004088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471004089 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 446471004090 pyruvate kinase; Provisional; Region: PRK06247 446471004091 domain interfaces; other site 446471004092 active site 446471004093 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 446471004094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471004095 active site 446471004096 phosphorylation site [posttranslational modification] 446471004097 intermolecular recognition site; other site 446471004098 dimerization interface [polypeptide binding]; other site 446471004099 ANTAR domain; Region: ANTAR; cl04297 446471004100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446471004101 Coenzyme A binding pocket [chemical binding]; other site 446471004102 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446471004103 CoenzymeA binding site [chemical binding]; other site 446471004104 subunit interaction site [polypeptide binding]; other site 446471004105 PHB binding site; other site 446471004106 DNA polymerase I; Provisional; Region: PRK05755 446471004107 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 446471004108 active site 446471004109 metal binding site 1 [ion binding]; metal-binding site 446471004110 putative 5' ssDNA interaction site; other site 446471004111 metal binding site 3; metal-binding site 446471004112 metal binding site 2 [ion binding]; metal-binding site 446471004113 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 446471004114 putative DNA binding site [nucleotide binding]; other site 446471004115 putative metal binding site [ion binding]; other site 446471004116 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 446471004117 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 446471004118 active site 446471004119 DNA binding site [nucleotide binding] 446471004120 catalytic site [active] 446471004121 Domain of unknown function (DUF368); Region: DUF368; cl00893 446471004122 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 446471004123 Protein of unknown function, DUF606; Region: DUF606; cl01273 446471004124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446471004125 S-adenosylmethionine binding site [chemical binding]; other site 446471004126 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 446471004127 6-phosphofructokinase; Provisional; Region: PRK03202 446471004128 active site 446471004129 ADP/pyrophosphate binding site [chemical binding]; other site 446471004130 dimerization interface [polypeptide binding]; other site 446471004131 allosteric effector site; other site 446471004132 fructose-1,6-bisphosphate binding site; other site 446471004133 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 446471004134 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 446471004135 RNA binding site [nucleotide binding]; other site 446471004136 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 446471004137 RNA binding site [nucleotide binding]; other site 446471004138 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446471004139 RNA binding site [nucleotide binding]; other site 446471004140 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 446471004141 RNA binding site [nucleotide binding]; other site 446471004142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471004143 TIGR01777 family protein; Region: yfcH 446471004144 NAD(P) binding site [chemical binding]; other site 446471004145 active site 446471004146 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 446471004147 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471004148 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471004149 Walker A/P-loop; other site 446471004150 ATP binding site [chemical binding]; other site 446471004151 Q-loop/lid; other site 446471004152 ABC transporter signature motif; other site 446471004153 Walker B; other site 446471004154 D-loop; other site 446471004155 H-loop/switch region; other site 446471004156 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471004157 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 446471004158 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471004159 Walker A/P-loop; other site 446471004160 ATP binding site [chemical binding]; other site 446471004161 Q-loop/lid; other site 446471004162 ABC transporter signature motif; other site 446471004163 Walker B; other site 446471004164 D-loop; other site 446471004165 H-loop/switch region; other site 446471004166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471004167 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 446471004168 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 446471004169 CoA-binding site [chemical binding]; other site 446471004170 ATP-binding [chemical binding]; other site 446471004171 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 446471004172 active site 446471004173 catalytic site [active] 446471004174 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 446471004175 oligomeric interface; other site 446471004176 putative active site [active] 446471004177 homodimer interface [polypeptide binding]; other site 446471004178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471004179 non-specific DNA binding site [nucleotide binding]; other site 446471004180 salt bridge; other site 446471004181 sequence-specific DNA binding site [nucleotide binding]; other site 446471004182 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 446471004183 active site 446471004184 NTP binding site [chemical binding]; other site 446471004185 metal binding triad [ion binding]; metal-binding site 446471004186 antibiotic binding site [chemical binding]; other site 446471004187 Protein of unknown function DUF86; Region: DUF86; cl01031 446471004188 excinuclease ABC subunit B; Provisional; Region: PRK05298 446471004189 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471004190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471004191 nucleotide binding region [chemical binding]; other site 446471004192 ATP-binding site [chemical binding]; other site 446471004193 Ultra-violet resistance protein B; Region: UvrB; pfam12344 446471004194 Integral membrane protein TerC family; Region: TerC; cl10468 446471004195 Integral membrane protein TerC family; Region: TerC; cl10468 446471004196 polycystin cation channel protein; Region: PCC; TIGR00864 446471004197 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 446471004198 polycystin cation channel protein; Region: PCC; TIGR00864 446471004199 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 446471004200 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 446471004201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471004202 YCII-related domain; Region: YCII; cl00999 446471004203 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 446471004204 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 446471004205 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 446471004206 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 446471004207 OsmC-like protein; Region: OsmC; cl00767 446471004208 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 446471004209 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 446471004210 GIY-YIG motif/motif A; other site 446471004211 active site 446471004212 catalytic site [active] 446471004213 putative DNA binding site [nucleotide binding]; other site 446471004214 metal binding site [ion binding]; metal-binding site 446471004215 UvrB/uvrC motif; Region: UVR; pfam02151 446471004216 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 446471004217 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471004218 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 446471004219 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 446471004220 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 446471004221 putative substrate binding pocket [chemical binding]; other site 446471004222 dimer interface [polypeptide binding]; other site 446471004223 phosphate binding site [ion binding]; other site 446471004224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 446471004225 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 446471004226 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 446471004227 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 446471004228 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 446471004229 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 446471004230 substrate binding site [chemical binding]; other site 446471004231 hinge regions; other site 446471004232 ADP binding site [chemical binding]; other site 446471004233 catalytic site [active] 446471004234 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 446471004235 substrate binding site [chemical binding]; other site 446471004236 dimer interface [polypeptide binding]; other site 446471004237 catalytic triad [active] 446471004238 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 446471004239 putative active site [active] 446471004240 opcA protein; Region: OpcA; TIGR00534 446471004241 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 446471004242 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 446471004243 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 446471004244 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 446471004245 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 446471004246 putative active site [active] 446471004247 catalytic residue [active] 446471004248 transketolase; Reviewed; Region: PRK05899 446471004249 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 446471004250 TPP-binding site [chemical binding]; other site 446471004251 dimer interface [polypeptide binding]; other site 446471004252 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446471004253 PYR/PP interface [polypeptide binding]; other site 446471004254 dimer interface [polypeptide binding]; other site 446471004255 TPP binding site [chemical binding]; other site 446471004256 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446471004257 UbiA prenyltransferase family; Region: UbiA; cl00337 446471004258 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 446471004259 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446471004260 DNA binding site [nucleotide binding] 446471004261 Int/Topo IB signature motif; other site 446471004262 active site 446471004263 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446471004264 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446471004265 P-loop; other site 446471004266 Magnesium ion binding site [ion binding]; other site 446471004267 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446471004268 Magnesium ion binding site [ion binding]; other site 446471004269 ScpA/B protein; Region: ScpA_ScpB; cl00598 446471004270 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 446471004271 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 446471004272 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446471004273 RNA binding surface [nucleotide binding]; other site 446471004274 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 446471004275 active site 446471004276 cytidylate kinase; Provisional; Region: cmk; PRK00023 446471004277 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 446471004278 CMP-binding site; other site 446471004279 The sites determining sugar specificity; other site 446471004280 GTP-binding protein Der; Reviewed; Region: PRK03003 446471004281 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 446471004282 G1 box; other site 446471004283 GTP/Mg2+ binding site [chemical binding]; other site 446471004284 Switch I region; other site 446471004285 G2 box; other site 446471004286 Switch II region; other site 446471004287 G3 box; other site 446471004288 G4 box; other site 446471004289 G5 box; other site 446471004290 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 446471004291 G1 box; other site 446471004292 GTP/Mg2+ binding site [chemical binding]; other site 446471004293 Switch I region; other site 446471004294 G2 box; other site 446471004295 G3 box; other site 446471004296 Switch II region; other site 446471004297 G4 box; other site 446471004298 G5 box; other site 446471004299 benzoate transport; Region: 2A0115; TIGR00895 446471004300 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446471004301 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471004302 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471004303 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 446471004304 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446471004305 Int/Topo IB signature motif; other site 446471004306 active site 446471004307 DNA binding site [nucleotide binding] 446471004308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471004309 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446471004310 dimer interface [polypeptide binding]; other site 446471004311 ssDNA binding site [nucleotide binding]; other site 446471004312 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446471004313 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 446471004314 type IV secretion system protein VirD4; Provisional; Region: PRK13850 446471004315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471004316 Walker A motif; other site 446471004317 ATP binding site [chemical binding]; other site 446471004318 Walker B motif; other site 446471004319 Phage integrase family; Region: Phage_integrase; pfam00589 446471004320 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 446471004321 DNA binding site [nucleotide binding] 446471004322 Int/Topo IB signature motif; other site 446471004323 active site 446471004324 catalytic residues [active] 446471004325 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471004326 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 446471004327 Walker A/P-loop; other site 446471004328 ATP binding site [chemical binding]; other site 446471004329 Q-loop/lid; other site 446471004330 ABC transporter signature motif; other site 446471004331 Walker B; other site 446471004332 D-loop; other site 446471004333 H-loop/switch region; other site 446471004334 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 446471004335 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446471004336 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 446471004337 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471004338 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471004339 Walker A/P-loop; other site 446471004340 ATP binding site [chemical binding]; other site 446471004341 Q-loop/lid; other site 446471004342 ABC transporter signature motif; other site 446471004343 Walker B; other site 446471004344 D-loop; other site 446471004345 H-loop/switch region; other site 446471004346 Transposase [DNA replication, recombination, and repair]; Region: COG5433 446471004347 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471004348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471004349 glycogen branching enzyme; Provisional; Region: PRK14705 446471004350 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 446471004351 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471004352 N-formylglutamate amidohydrolase; Region: FGase; cl01522 446471004353 Domain of unknown function (DUF385); Region: DUF385; cl04387 446471004354 FtsX-like permease family; Region: FtsX; pfam02687 446471004355 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471004356 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471004357 Walker A/P-loop; other site 446471004358 ATP binding site [chemical binding]; other site 446471004359 Q-loop/lid; other site 446471004360 ABC transporter signature motif; other site 446471004361 Walker B; other site 446471004362 D-loop; other site 446471004363 H-loop/switch region; other site 446471004364 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446471004365 Histidine kinase; Region: HisKA_3; pfam07730 446471004366 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471004367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471004368 active site 446471004369 phosphorylation site [posttranslational modification] 446471004370 intermolecular recognition site; other site 446471004371 dimerization interface [polypeptide binding]; other site 446471004372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471004373 DNA binding residues [nucleotide binding] 446471004374 dimerization interface [polypeptide binding]; other site 446471004375 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471004376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471004377 active site 446471004378 phosphorylation site [posttranslational modification] 446471004379 intermolecular recognition site; other site 446471004380 dimerization interface [polypeptide binding]; other site 446471004381 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471004382 DNA binding residues [nucleotide binding] 446471004383 dimerization interface [polypeptide binding]; other site 446471004384 Histidine kinase; Region: HisKA_3; pfam07730 446471004385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446471004386 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 446471004387 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446471004388 nitrite reductase subunit NirD; Provisional; Region: PRK14989 446471004389 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 446471004390 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 446471004391 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446471004392 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 446471004393 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 446471004394 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 446471004395 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 446471004396 putative active site [active] 446471004397 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 446471004398 active site 446471004399 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 446471004400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471004401 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471004402 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471004403 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 446471004404 Uncharacterized conserved protein [Function unknown]; Region: COG4832 446471004405 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 446471004406 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 446471004407 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446471004408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471004409 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471004410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471004411 active site 446471004412 phosphorylation site [posttranslational modification] 446471004413 intermolecular recognition site; other site 446471004414 dimerization interface [polypeptide binding]; other site 446471004415 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471004416 DNA binding residues [nucleotide binding] 446471004417 dimerization interface [polypeptide binding]; other site 446471004418 Histidine kinase; Region: HisKA_3; pfam07730 446471004419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446471004420 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 446471004421 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 446471004422 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446471004423 dimerization interface [polypeptide binding]; other site 446471004424 putative DNA binding site [nucleotide binding]; other site 446471004425 Predicted transcriptional regulator [Transcription]; Region: COG2345 446471004426 putative Zn2+ binding site [ion binding]; other site 446471004427 potential frameshift: common BLAST hit: gi|256831401|ref|YP_003160128.1| Nitrite reductase (NO-forming) 446471004428 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 446471004429 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 446471004430 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 446471004431 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 446471004432 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471004433 active site 446471004434 nucleotide binding site [chemical binding]; other site 446471004435 HIGH motif; other site 446471004436 KMSKS motif; other site 446471004437 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 446471004438 tetramerization interface [polypeptide binding]; other site 446471004439 active site 446471004440 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 446471004441 oligomerization interface [polypeptide binding]; other site 446471004442 active site 446471004443 metal binding site [ion binding]; metal-binding site 446471004444 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 446471004445 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 446471004446 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446471004447 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 446471004448 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 446471004449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471004450 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446471004451 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446471004452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471004453 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446471004454 DinB superfamily; Region: DinB_2; cl00986 446471004455 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 446471004456 Fe-S cluster binding site [ion binding]; other site 446471004457 DNA binding site [nucleotide binding] 446471004458 active site 446471004459 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl03735 446471004460 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 446471004461 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 446471004462 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 446471004463 active site 446471004464 dimer interface [polypeptide binding]; other site 446471004465 motif 1; other site 446471004466 motif 2; other site 446471004467 motif 3; other site 446471004468 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 446471004469 anticodon binding site; other site 446471004470 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 446471004471 nucleotide binding site/active site [active] 446471004472 HIT family signature motif; other site 446471004473 catalytic residue [active] 446471004474 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 446471004475 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471004476 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 446471004477 putative acyl-acceptor binding pocket; other site 446471004478 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446471004479 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446471004480 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 446471004481 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 446471004482 active site 446471004483 multimer interface [polypeptide binding]; other site 446471004484 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 446471004485 nudix motif; other site 446471004486 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 446471004487 predicted active site [active] 446471004488 catalytic triad [active] 446471004489 Domain of unknown function DUF28; Region: DUF28; cl00361 446471004490 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 446471004491 active site 446471004492 putative DNA-binding cleft [nucleotide binding]; other site 446471004493 dimer interface [polypeptide binding]; other site 446471004494 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 446471004495 RuvA N terminal domain; Region: RuvA_N; pfam01330 446471004496 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 446471004497 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 446471004498 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 446471004499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471004500 Walker A motif; other site 446471004501 ATP binding site [chemical binding]; other site 446471004502 Walker B motif; other site 446471004503 arginine finger; other site 446471004504 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 446471004505 Preprotein translocase subunit; Region: YajC; cl00806 446471004506 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 446471004507 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 446471004508 Protein export membrane protein; Region: SecD_SecF; cl14618 446471004509 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 446471004510 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 446471004511 Protein export membrane protein; Region: SecD_SecF; cl14618 446471004512 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446471004513 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 446471004514 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 446471004515 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446471004516 synthetase active site [active] 446471004517 NTP binding site [chemical binding]; other site 446471004518 metal binding site [ion binding]; metal-binding site 446471004519 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 446471004520 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 446471004521 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 446471004522 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 446471004523 active site 446471004524 DNA binding site [nucleotide binding] 446471004525 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 446471004526 DNA binding site [nucleotide binding] 446471004527 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 446471004528 nucleotide binding site [chemical binding]; other site 446471004529 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446471004530 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446471004531 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 446471004532 active site 446471004533 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446471004534 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 446471004535 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 446471004536 dimer interface [polypeptide binding]; other site 446471004537 motif 1; other site 446471004538 active site 446471004539 motif 2; other site 446471004540 motif 3; other site 446471004541 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 446471004542 anticodon binding site; other site 446471004543 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 446471004544 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 446471004545 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 446471004546 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 446471004547 dimer interface [polypeptide binding]; other site 446471004548 anticodon binding site; other site 446471004549 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 446471004550 homodimer interface [polypeptide binding]; other site 446471004551 motif 1; other site 446471004552 active site 446471004553 motif 2; other site 446471004554 GAD domain; Region: GAD; pfam02938 446471004555 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 446471004556 active site 446471004557 motif 3; other site 446471004558 Predicted acetyltransferase [General function prediction only]; Region: COG3393 446471004559 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446471004560 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446471004561 recombination factor protein RarA; Reviewed; Region: PRK13342 446471004562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471004563 Walker A motif; other site 446471004564 ATP binding site [chemical binding]; other site 446471004565 Walker B motif; other site 446471004566 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 446471004567 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 446471004568 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 446471004569 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446471004570 RNA binding surface [nucleotide binding]; other site 446471004571 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 446471004572 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 446471004573 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 446471004574 motif 1; other site 446471004575 active site 446471004576 motif 2; other site 446471004577 motif 3; other site 446471004578 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 446471004579 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 446471004580 YceG-like family; Region: YceG; pfam02618 446471004581 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 446471004582 dimerization interface [polypeptide binding]; other site 446471004583 YceG-like family; Region: YceG; pfam02618 446471004584 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 446471004585 dimerization interface [polypeptide binding]; other site 446471004586 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 446471004587 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 446471004588 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 446471004589 shikimate binding site; other site 446471004590 NAD(P) binding site [chemical binding]; other site 446471004591 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 446471004592 Tetramer interface [polypeptide binding]; other site 446471004593 active site 446471004594 FMN-binding site [chemical binding]; other site 446471004595 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 446471004596 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 446471004597 ADP binding site [chemical binding]; other site 446471004598 magnesium binding site [ion binding]; other site 446471004599 putative shikimate binding site; other site 446471004600 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 446471004601 active site 446471004602 dimer interface [polypeptide binding]; other site 446471004603 metal binding site [ion binding]; metal-binding site 446471004604 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 446471004605 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446471004606 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446471004607 active site 446471004608 catalytic site [active] 446471004609 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446471004610 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471004611 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 446471004612 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 446471004613 phosphate binding site [ion binding]; other site 446471004614 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 446471004615 Protein of unknown function (DUF419); Region: DUF419; cl15265 446471004616 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 446471004617 trimer interface [polypeptide binding]; other site 446471004618 active site 446471004619 dimer interface [polypeptide binding]; other site 446471004620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471004621 elongation factor P; Validated; Region: PRK00529 446471004622 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 446471004623 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 446471004624 RNA binding site [nucleotide binding]; other site 446471004625 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 446471004626 RNA binding site [nucleotide binding]; other site 446471004627 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 446471004628 putative RNA binding site [nucleotide binding]; other site 446471004629 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446471004630 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 446471004631 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446471004632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471004633 dihydroorotase; Validated; Region: pyrC; PRK09357 446471004634 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446471004635 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 446471004636 active site 446471004637 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 446471004638 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 446471004639 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 446471004640 catalytic site [active] 446471004641 subunit interface [polypeptide binding]; other site 446471004642 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 446471004643 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446471004644 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446471004645 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446471004646 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446471004647 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 446471004648 IMP binding site; other site 446471004649 dimer interface [polypeptide binding]; other site 446471004650 interdomain contacts; other site 446471004651 partial ornithine binding site; other site 446471004652 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 446471004653 active site 446471004654 dimer interface [polypeptide binding]; other site 446471004655 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 446471004656 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 446471004657 catalytic site [active] 446471004658 G-X2-G-X-G-K; other site 446471004659 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 446471004660 Flavoprotein; Region: Flavoprotein; cl08021 446471004661 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 446471004662 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 446471004663 S-adenosylmethionine synthetase; Validated; Region: PRK05250 446471004664 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 446471004665 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 446471004666 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 446471004667 primosome assembly protein PriA; Provisional; Region: PRK14873 446471004668 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446471004669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446471004670 motif II; other site 446471004671 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 446471004672 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 446471004673 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 446471004674 putative active site [active] 446471004675 substrate binding site [chemical binding]; other site 446471004676 putative cosubstrate binding site; other site 446471004677 catalytic site [active] 446471004678 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 446471004679 substrate binding site [chemical binding]; other site 446471004680 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 446471004681 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 446471004682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446471004683 S-adenosylmethionine binding site [chemical binding]; other site 446471004684 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 446471004685 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 446471004686 substrate binding site [chemical binding]; other site 446471004687 hexamer interface [polypeptide binding]; other site 446471004688 metal binding site [ion binding]; metal-binding site 446471004689 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 446471004690 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 446471004691 catalytic motif [active] 446471004692 Zn binding site [ion binding]; other site 446471004693 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 446471004694 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 446471004695 Lumazine binding domain; Region: Lum_binding; pfam00677 446471004696 Lumazine binding domain; Region: Lum_binding; pfam00677 446471004697 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 446471004698 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 446471004699 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 446471004700 dimerization interface [polypeptide binding]; other site 446471004701 active site 446471004702 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 446471004703 active site 446471004704 homopentamer interface [polypeptide binding]; other site 446471004705 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 446471004706 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 446471004707 ATP phosphoribosyltransferase; Region: HisG; cl15266 446471004708 HisG, C-terminal domain; Region: HisG_C; cl06867 446471004709 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446471004710 helicase 45; Provisional; Region: PTZ00424 446471004711 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446471004712 ATP binding site [chemical binding]; other site 446471004713 Mg++ binding site [ion binding]; other site 446471004714 motif III; other site 446471004715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471004716 nucleotide binding region [chemical binding]; other site 446471004717 ATP-binding site [chemical binding]; other site 446471004718 DbpA RNA binding domain; Region: DbpA; pfam03880 446471004719 transcription termination factor Rho; Provisional; Region: PRK12678 446471004720 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 446471004721 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 446471004722 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 446471004723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 446471004724 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 446471004725 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446471004726 phosphopeptide binding site; other site 446471004727 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446471004728 DNA binding residues [nucleotide binding] 446471004729 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 446471004730 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 446471004731 DNA binding residues [nucleotide binding] 446471004732 putative dimer interface [polypeptide binding]; other site 446471004733 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446471004734 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 446471004735 putative active site [active] 446471004736 catalytic site [active] 446471004737 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446471004738 putative active site [active] 446471004739 catalytic site [active] 446471004740 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 446471004741 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446471004742 DNA binding site [nucleotide binding] 446471004743 Int/Topo IB signature motif; other site 446471004744 active site 446471004745 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446471004746 conserved cys residue [active] 446471004747 PemK-like protein; Region: PemK; cl00995 446471004748 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 446471004749 putative active site [active] 446471004750 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 446471004751 HipA N-terminal domain; Region: couple_hipA; TIGR03071 446471004752 HipA-like N-terminal domain; Region: HipA_N; pfam07805 446471004753 HipA-like C-terminal domain; Region: HipA_C; pfam07804 446471004754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471004755 hypothetical protein; Provisional; Region: PRK06771 446471004756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471004757 Walker A/P-loop; other site 446471004758 ATP binding site [chemical binding]; other site 446471004759 Q-loop/lid; other site 446471004760 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 446471004761 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471004762 Walker A/P-loop; other site 446471004763 ATP binding site [chemical binding]; other site 446471004764 Q-loop/lid; other site 446471004765 ABC transporter signature motif; other site 446471004766 Walker B; other site 446471004767 D-loop; other site 446471004768 H-loop/switch region; other site 446471004769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446471004770 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446471004771 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446471004772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446471004773 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 446471004774 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471004775 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 446471004776 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 446471004777 oligomeric interface; other site 446471004778 putative active site [active] 446471004779 homodimer interface [polypeptide binding]; other site 446471004780 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 446471004781 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446471004782 Ligand Binding Site [chemical binding]; other site 446471004783 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 446471004784 putative hydrophobic ligand binding site [chemical binding]; other site 446471004785 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 446471004786 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 446471004787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471004788 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 446471004789 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 446471004790 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446471004791 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446471004792 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 446471004793 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 446471004794 putative active site [active] 446471004795 catalytic triad [active] 446471004796 putative dimer interface [polypeptide binding]; other site 446471004797 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 446471004798 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446471004799 active site 446471004800 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 446471004801 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471004802 ATP binding site [chemical binding]; other site 446471004803 putative Mg++ binding site [ion binding]; other site 446471004804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471004805 nucleotide binding region [chemical binding]; other site 446471004806 ATP-binding site [chemical binding]; other site 446471004807 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 446471004808 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 446471004809 diacylglycerol kinase; Reviewed; Region: PRK11914 446471004810 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 446471004811 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 446471004812 Predicted transcriptional regulator [Transcription]; Region: COG2378 446471004813 Predicted transcriptional regulator [Transcription]; Region: COG2378 446471004814 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 446471004815 MoxR-like ATPases [General function prediction only]; Region: COG0714 446471004816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471004817 Walker A motif; other site 446471004818 ATP binding site [chemical binding]; other site 446471004819 Walker B motif; other site 446471004820 arginine finger; other site 446471004821 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446471004822 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446471004823 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471004824 Ferritin-like domain; Region: Ferritin; pfam00210 446471004825 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 446471004826 dimerization interface [polypeptide binding]; other site 446471004827 DPS ferroxidase diiron center [ion binding]; other site 446471004828 ion pore; other site 446471004829 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 446471004830 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 446471004831 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471004832 active site 446471004833 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 446471004834 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446471004835 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471004836 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446471004837 putative dimerization interface [polypeptide binding]; other site 446471004838 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 446471004839 Fic family protein [Function unknown]; Region: COG3177 446471004840 Fic/DOC family; Region: Fic; cl00960 446471004841 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 446471004842 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446471004843 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446471004844 active site 446471004845 Penicillin amidase; Region: Penicil_amidase; pfam01804 446471004846 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 446471004847 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 446471004848 IucA / IucC family; Region: IucA_IucC; pfam04183 446471004849 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 446471004850 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 446471004851 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446471004852 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446471004853 catalytic residue [active] 446471004854 Protein of unknown function (DUF1222); Region: DUF1222; pfam06762 446471004855 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471004856 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471004857 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471004858 Walker A/P-loop; other site 446471004859 ATP binding site [chemical binding]; other site 446471004860 Q-loop/lid; other site 446471004861 ABC transporter signature motif; other site 446471004862 Walker B; other site 446471004863 D-loop; other site 446471004864 H-loop/switch region; other site 446471004865 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 446471004866 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471004867 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471004868 Walker A/P-loop; other site 446471004869 ATP binding site [chemical binding]; other site 446471004870 Q-loop/lid; other site 446471004871 ABC transporter signature motif; other site 446471004872 Walker B; other site 446471004873 D-loop; other site 446471004874 H-loop/switch region; other site 446471004875 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446471004876 active site 446471004877 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446471004878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471004879 NAD(P) binding site [chemical binding]; other site 446471004880 active site 446471004881 Domain of unknown function (DUF305); Region: DUF305; pfam03713 446471004882 Domain of unknown function (DUF305); Region: DUF305; pfam03713 446471004883 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 446471004884 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 446471004885 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 446471004886 active site 446471004887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471004888 DNA binding site [nucleotide binding] 446471004889 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 446471004890 nitrite reductase subunit NirD; Provisional; Region: PRK14989 446471004891 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 446471004892 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446471004893 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 446471004894 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 446471004895 ATP binding site [chemical binding]; other site 446471004896 substrate interface [chemical binding]; other site 446471004897 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446471004898 active site residue [active] 446471004899 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 446471004900 MPT binding site; other site 446471004901 trimer interface [polypeptide binding]; other site 446471004902 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 446471004903 MoaE homodimer interface [polypeptide binding]; other site 446471004904 MoaD interaction [polypeptide binding]; other site 446471004905 active site residues [active] 446471004906 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 446471004907 trimer interface [polypeptide binding]; other site 446471004908 dimer interface [polypeptide binding]; other site 446471004909 putative active site [active] 446471004910 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446471004911 dimer interface [polypeptide binding]; other site 446471004912 putative functional site; other site 446471004913 putative MPT binding site; other site 446471004914 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 446471004915 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 446471004916 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 446471004917 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 446471004918 [4Fe-4S] binding site [ion binding]; other site 446471004919 molybdopterin cofactor binding site; other site 446471004920 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 446471004921 molybdopterin cofactor binding site; other site 446471004922 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 446471004923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471004924 DNA binding residues [nucleotide binding] 446471004925 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 446471004926 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 446471004927 [4Fe-4S] binding site [ion binding]; other site 446471004928 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446471004929 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446471004930 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446471004931 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 446471004932 molybdopterin cofactor binding site; other site 446471004933 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 446471004934 4Fe-4S binding domain; Region: Fer4; cl02805 446471004935 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 446471004936 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 446471004937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471004938 putative substrate translocation pore; other site 446471004939 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446471004940 dimer interface [polypeptide binding]; other site 446471004941 putative functional site; other site 446471004942 putative MPT binding site; other site 446471004943 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471004944 active site 446471004945 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 446471004946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446471004947 FeS/SAM binding site; other site 446471004948 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 446471004949 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446471004950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471004951 putative substrate translocation pore; other site 446471004952 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446471004953 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446471004954 Catalytic site [active] 446471004955 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446471004956 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446471004957 ligand binding site [chemical binding]; other site 446471004958 flexible hinge region; other site 446471004959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471004960 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 446471004961 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 446471004962 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 446471004963 substrate binding site [chemical binding]; other site 446471004964 methionine synthase; Provisional; Region: PRK01207 446471004965 THF binding site; other site 446471004966 zinc-binding site [ion binding]; other site 446471004967 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 446471004968 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 446471004969 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 446471004970 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 446471004971 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 446471004972 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 446471004973 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446471004974 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471004975 Walker A/P-loop; other site 446471004976 ATP binding site [chemical binding]; other site 446471004977 Q-loop/lid; other site 446471004978 ABC transporter signature motif; other site 446471004979 Walker B; other site 446471004980 D-loop; other site 446471004981 H-loop/switch region; other site 446471004982 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471004983 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446471004984 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471004985 Walker A/P-loop; other site 446471004986 ATP binding site [chemical binding]; other site 446471004987 Q-loop/lid; other site 446471004988 ABC transporter signature motif; other site 446471004989 Walker B; other site 446471004990 D-loop; other site 446471004991 H-loop/switch region; other site 446471004992 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471004993 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 446471004994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471004995 dimer interface [polypeptide binding]; other site 446471004996 conserved gate region; other site 446471004997 putative PBP binding loops; other site 446471004998 ABC-ATPase subunit interface; other site 446471004999 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446471005000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471005001 dimer interface [polypeptide binding]; other site 446471005002 conserved gate region; other site 446471005003 putative PBP binding loops; other site 446471005004 ABC-ATPase subunit interface; other site 446471005005 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 446471005006 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 446471005007 peptide binding site [polypeptide binding]; other site 446471005008 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 446471005009 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446471005010 Walker A/P-loop; other site 446471005011 ATP binding site [chemical binding]; other site 446471005012 Q-loop/lid; other site 446471005013 ABC transporter signature motif; other site 446471005014 Walker B; other site 446471005015 D-loop; other site 446471005016 H-loop/switch region; other site 446471005017 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446471005018 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446471005019 Walker A/P-loop; other site 446471005020 ATP binding site [chemical binding]; other site 446471005021 Q-loop/lid; other site 446471005022 ABC transporter signature motif; other site 446471005023 Walker B; other site 446471005024 D-loop; other site 446471005025 H-loop/switch region; other site 446471005026 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446471005027 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446471005028 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 446471005029 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446471005030 Domain of unknown function DUF21; Region: DUF21; pfam01595 446471005031 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446471005032 Transporter associated domain; Region: CorC_HlyC; cl08393 446471005033 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446471005034 intersubunit interface [polypeptide binding]; other site 446471005035 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446471005036 GatB domain; Region: GatB_Yqey; cl11497 446471005037 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 446471005038 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446471005039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005040 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 446471005041 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 446471005042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446471005043 dimerization interface [polypeptide binding]; other site 446471005044 putative DNA binding site [nucleotide binding]; other site 446471005045 putative Zn2+ binding site [ion binding]; other site 446471005046 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 446471005047 putative hydrophobic ligand binding site [chemical binding]; other site 446471005048 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 446471005049 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 446471005050 active site residue [active] 446471005051 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 446471005052 active site 446471005053 nucleophile elbow; other site 446471005054 Phosphotransferase enzyme family; Region: APH; pfam01636 446471005055 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 446471005056 substrate binding site [chemical binding]; other site 446471005057 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 446471005058 homodimer interface [polypeptide binding]; other site 446471005059 substrate-cofactor binding pocket; other site 446471005060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471005061 catalytic residue [active] 446471005062 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 446471005063 chorismate binding enzyme; Region: Chorismate_bind; cl10555 446471005064 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 446471005065 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 446471005066 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 446471005067 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 446471005068 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 446471005069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471005070 Walker A motif; other site 446471005071 ATP binding site [chemical binding]; other site 446471005072 Walker B motif; other site 446471005073 arginine finger; other site 446471005074 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 446471005075 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 446471005076 aspartate racemase; Region: asp_race; TIGR00035 446471005077 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 446471005078 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446471005079 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446471005080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005081 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 446471005082 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 446471005083 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 446471005084 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 446471005085 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 446471005086 putative active site [active] 446471005087 catalytic site [active] 446471005088 putative substrate binding site [chemical binding]; other site 446471005089 HRDC domain; Region: HRDC; cl02578 446471005090 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446471005091 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 446471005092 dimer interface [polypeptide binding]; other site 446471005093 active site 446471005094 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446471005095 substrate binding site [chemical binding]; other site 446471005096 oxyanion hole (OAH) forming residues; other site 446471005097 trimer interface [polypeptide binding]; other site 446471005098 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 446471005099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471005100 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446471005101 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 446471005102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446471005103 FeS/SAM binding site; other site 446471005104 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 446471005105 Pyruvate formate lyase 1; Region: PFL1; cd01678 446471005106 coenzyme A binding site [chemical binding]; other site 446471005107 active site 446471005108 catalytic residues [active] 446471005109 glycine loop; other site 446471005110 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446471005111 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 446471005112 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 446471005113 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 446471005114 TPP-binding site; other site 446471005115 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446471005116 PYR/PP interface [polypeptide binding]; other site 446471005117 dimer interface [polypeptide binding]; other site 446471005118 TPP binding site [chemical binding]; other site 446471005119 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446471005120 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 446471005121 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 446471005122 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 446471005123 active site 446471005124 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446471005125 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471005126 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446471005127 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471005128 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 446471005129 putative active site [active] 446471005130 putative CoA binding site [chemical binding]; other site 446471005131 nudix motif; other site 446471005132 metal binding site [ion binding]; metal-binding site 446471005133 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 446471005134 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446471005135 active site 446471005136 substrate binding site [chemical binding]; other site 446471005137 ATP binding site [chemical binding]; other site 446471005138 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446471005139 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446471005140 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471005141 Walker A/P-loop; other site 446471005142 ATP binding site [chemical binding]; other site 446471005143 Q-loop/lid; other site 446471005144 ABC transporter signature motif; other site 446471005145 Walker B; other site 446471005146 D-loop; other site 446471005147 H-loop/switch region; other site 446471005148 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471005149 aconitate hydratase; Validated; Region: PRK09277 446471005150 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446471005151 substrate binding site [chemical binding]; other site 446471005152 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446471005153 ligand binding site [chemical binding]; other site 446471005154 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 446471005155 substrate binding site [chemical binding]; other site 446471005156 Uncharacterized conserved protein [Function unknown]; Region: COG1432 446471005157 LabA_like proteins; Region: LabA_like; cd06167 446471005158 putative metal binding site [ion binding]; other site 446471005159 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 446471005160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 446471005161 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 446471005162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471005163 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 446471005164 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446471005165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005166 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 446471005167 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446471005168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005169 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 446471005170 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 446471005171 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 446471005172 ssDNA binding site; other site 446471005173 generic binding surface II; other site 446471005174 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 446471005175 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446471005176 trimer interface [polypeptide binding]; other site 446471005177 active site 446471005178 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 446471005179 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 446471005180 active site 446471005181 dimerization interface [polypeptide binding]; other site 446471005182 Predicted membrane protein [Function unknown]; Region: COG2860 446471005183 UPF0126 domain; Region: UPF0126; pfam03458 446471005184 UPF0126 domain; Region: UPF0126; pfam03458 446471005185 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 446471005186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471005187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471005188 Thymidine kinase; Region: TK; cl00631 446471005189 Sulfatase; Region: Sulfatase; cl10460 446471005190 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 446471005191 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 446471005192 EamA-like transporter family; Region: EamA; cl01037 446471005193 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 446471005194 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 446471005195 CAP-like domain; other site 446471005196 active site 446471005197 primary dimer interface [polypeptide binding]; other site 446471005198 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471005199 YhhN-like protein; Region: YhhN; cl01505 446471005200 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471005201 G1 box; other site 446471005202 GTP/Mg2+ binding site [chemical binding]; other site 446471005203 G2 box; other site 446471005204 Switch I region; other site 446471005205 G3 box; other site 446471005206 Switch II region; other site 446471005207 G4 box; other site 446471005208 G5 box; other site 446471005209 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 446471005210 Nucleoside recognition; Region: Gate; cl00486 446471005211 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 446471005212 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 446471005213 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 446471005214 substrate binding pocket [chemical binding]; other site 446471005215 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 446471005216 B12 binding site [chemical binding]; other site 446471005217 cobalt ligand [ion binding]; other site 446471005218 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 446471005219 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 446471005220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471005221 Walker A motif; other site 446471005222 ATP binding site [chemical binding]; other site 446471005223 Walker B motif; other site 446471005224 arginine finger; other site 446471005225 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 446471005226 Baseplate J-like protein; Region: Baseplate_J; cl01294 446471005227 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 446471005228 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 446471005229 Phage protein D [General function prediction only]; Region: COG3500; cl12180 446471005230 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 446471005231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 446471005232 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 446471005233 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 446471005234 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 446471005235 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 446471005236 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 446471005237 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 446471005238 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 446471005239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446471005240 Coenzyme A binding pocket [chemical binding]; other site 446471005241 Protein of unknown function (DUF805); Region: DUF805; cl01224 446471005242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471005243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005244 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446471005245 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 446471005246 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471005247 Walker A/P-loop; other site 446471005248 ATP binding site [chemical binding]; other site 446471005249 Q-loop/lid; other site 446471005250 ABC transporter signature motif; other site 446471005251 Walker B; other site 446471005252 D-loop; other site 446471005253 H-loop/switch region; other site 446471005254 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 446471005255 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446471005256 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 446471005257 active site residue [active] 446471005258 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 446471005259 putative homotetramer interface [polypeptide binding]; other site 446471005260 putative homodimer interface [polypeptide binding]; other site 446471005261 putative allosteric switch controlling residues; other site 446471005262 putative metal binding site [ion binding]; other site 446471005263 putative homodimer-homodimer interface [polypeptide binding]; other site 446471005264 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 446471005265 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 446471005266 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 446471005267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 446471005268 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446471005269 Predicted transcriptional regulator [Transcription]; Region: COG1959 446471005270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005271 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 446471005272 Flavin Reductases; Region: FlaRed; cl00801 446471005273 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 446471005274 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 446471005275 RDD family; Region: RDD; cl00746 446471005276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005277 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 446471005278 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446471005279 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471005280 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 446471005281 YCII-related domain; Region: YCII; cl00999 446471005282 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 446471005283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471005284 ATP binding site [chemical binding]; other site 446471005285 Mg2+ binding site [ion binding]; other site 446471005286 G-X-G motif; other site 446471005287 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 446471005288 anchoring element; other site 446471005289 dimer interface [polypeptide binding]; other site 446471005290 ATP binding site [chemical binding]; other site 446471005291 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 446471005292 active site 446471005293 metal binding site [ion binding]; metal-binding site 446471005294 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446471005295 FAD binding domain; Region: FAD_binding_4; pfam01565 446471005296 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446471005297 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446471005298 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471005299 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446471005300 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446471005301 DNA binding residues [nucleotide binding] 446471005302 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446471005303 Ligand Binding Site [chemical binding]; other site 446471005304 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446471005305 substrate binding pocket [chemical binding]; other site 446471005306 chain length determination region; other site 446471005307 substrate-Mg2+ binding site; other site 446471005308 catalytic residues [active] 446471005309 aspartate-rich region 1; other site 446471005310 active site lid residues [active] 446471005311 aspartate-rich region 2; other site 446471005312 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471005313 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446471005314 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446471005315 active site 446471005316 ATP binding site [chemical binding]; other site 446471005317 substrate binding site [chemical binding]; other site 446471005318 activation loop (A-loop); other site 446471005319 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446471005320 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446471005321 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446471005322 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446471005323 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 446471005324 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 446471005325 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 446471005326 active site 446471005327 ADP/pyrophosphate binding site [chemical binding]; other site 446471005328 allosteric effector site; other site 446471005329 dimerization interface [polypeptide binding]; other site 446471005330 fructose-1,6-bisphosphate binding site; other site 446471005331 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446471005332 putative acyl-acceptor binding pocket; other site 446471005333 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 446471005334 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446471005335 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446471005336 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 446471005337 hypothetical protein; Validated; Region: PRK07883 446471005338 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446471005339 active site 446471005340 substrate binding site [chemical binding]; other site 446471005341 catalytic site [active] 446471005342 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 446471005343 GIY-YIG motif/motif A; other site 446471005344 active site 446471005345 catalytic site [active] 446471005346 putative DNA binding site [nucleotide binding]; other site 446471005347 metal binding site [ion binding]; metal-binding site 446471005348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005349 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 446471005350 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446471005351 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446471005352 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 446471005353 Subunit I/III interface [polypeptide binding]; other site 446471005354 Cytochrome c; Region: Cytochrom_C; cl11414 446471005355 Cytochrome c; Region: Cytochrom_C; cl11414 446471005356 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 446471005357 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 446471005358 iron-sulfur cluster [ion binding]; other site 446471005359 [2Fe-2S] cluster binding site [ion binding]; other site 446471005360 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 446471005361 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 446471005362 heme bH binding site [chemical binding]; other site 446471005363 intrachain domain interface; other site 446471005364 heme bL binding site [chemical binding]; other site 446471005365 interchain domain interface [polypeptide binding]; other site 446471005366 Qo binding site; other site 446471005367 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 446471005368 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 446471005369 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 446471005370 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 446471005371 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 446471005372 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 446471005373 D-pathway; other site 446471005374 Putative ubiquinol binding site [chemical binding]; other site 446471005375 Low-spin heme (heme b) binding site [chemical binding]; other site 446471005376 Putative water exit pathway; other site 446471005377 Binuclear center (heme o3/CuB) [ion binding]; other site 446471005378 K-pathway; other site 446471005379 Putative proton exit pathway; other site 446471005380 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 446471005381 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 446471005382 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 446471005383 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 446471005384 conserved cys residue [active] 446471005385 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446471005386 active site 446471005387 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 446471005388 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 446471005389 active site 446471005390 metal binding site [ion binding]; metal-binding site 446471005391 dimer interface [polypeptide binding]; other site 446471005392 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 446471005393 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 446471005394 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446471005395 active site 446471005396 catalytic tetrad [active] 446471005397 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 446471005398 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 446471005399 quinone interaction residues [chemical binding]; other site 446471005400 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 446471005401 active site 446471005402 catalytic residues [active] 446471005403 FMN binding site [chemical binding]; other site 446471005404 substrate binding site [chemical binding]; other site 446471005405 multifunctional aminopeptidase A; Provisional; Region: PRK00913 446471005406 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 446471005407 interface (dimer of trimers) [polypeptide binding]; other site 446471005408 Substrate-binding/catalytic site; other site 446471005409 Zn-binding sites [ion binding]; other site 446471005410 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446471005411 E3 interaction surface; other site 446471005412 lipoyl attachment site [posttranslational modification]; other site 446471005413 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446471005414 E3 interaction surface; other site 446471005415 lipoyl attachment site [posttranslational modification]; other site 446471005416 e3 binding domain; Region: E3_binding; pfam02817 446471005417 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 446471005418 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 446471005419 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 446471005420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005421 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446471005422 putative oxidoreductase; Provisional; Region: PRK11579 446471005423 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 446471005424 lipoyl synthase; Provisional; Region: PRK05481 446471005425 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446471005426 FeS/SAM binding site; other site 446471005427 RDD family; Region: RDD; cl00746 446471005428 glutamine synthetase, type I; Region: GlnA; TIGR00653 446471005429 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446471005430 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446471005431 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471005432 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471005433 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471005434 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471005435 Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; Region: CDC6; COG1474 446471005436 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471005437 Walker A motif; other site 446471005438 ATP binding site [chemical binding]; other site 446471005439 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471005440 DNA binding residues [nucleotide binding] 446471005441 dimerization interface [polypeptide binding]; other site 446471005442 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471005443 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471005444 elongation factor G; Reviewed; Region: PRK12740 446471005445 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471005446 GTP/Mg2+ binding site [chemical binding]; other site 446471005447 G1 box; other site 446471005448 G2 box; other site 446471005449 Switch I region; other site 446471005450 G3 box; other site 446471005451 Switch II region; other site 446471005452 G4 box; other site 446471005453 G5 box; other site 446471005454 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 446471005455 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 446471005456 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 446471005457 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 446471005458 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 446471005459 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 446471005460 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446471005461 metal binding triad; other site 446471005462 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446471005463 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446471005464 metal binding triad; other site 446471005465 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446471005466 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 446471005467 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446471005468 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446471005469 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446471005470 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446471005471 anti sigma factor interaction site; other site 446471005472 regulatory phosphorylation site [posttranslational modification]; other site 446471005473 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 446471005474 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 446471005475 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 446471005476 Protein of unknown function (DUF433); Region: DUF433; cl01030 446471005477 Protein of unknown function (DUF805); Region: DUF805; cl01224 446471005478 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446471005479 DNA binding site [nucleotide binding] 446471005480 active site 446471005481 Int/Topo IB signature motif; other site 446471005482 Phage capsid family; Region: Phage_capsid; pfam05065 446471005483 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471005484 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446471005485 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446471005486 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446471005487 DNA binding site [nucleotide binding] 446471005488 active site 446471005489 Int/Topo IB signature motif; other site 446471005490 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 446471005491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005492 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471005493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005494 Bacterial membrane flanked domain; Region: DUF304; cl01348 446471005495 Predicted membrane protein [Function unknown]; Region: COG3428 446471005496 Bacterial membrane flanked domain; Region: DUF304; cl01348 446471005497 Bacterial membrane flanked domain; Region: DUF304; cl01348 446471005498 Protein of unknown function (DUF328); Region: DUF328; cl01143 446471005499 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 446471005500 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 446471005501 RNA/DNA hybrid binding site [nucleotide binding]; other site 446471005502 active site 446471005503 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446471005504 catalytic core [active] 446471005505 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 446471005506 Putative zinc ribbon domain; Region: DUF164; pfam02591 446471005507 Uncharacterized conserved protein [Function unknown]; Region: COG0327 446471005508 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 446471005509 putative transporter; Provisional; Region: PRK11660 446471005510 Permease family; Region: Xan_ur_permease; cl00967 446471005511 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 446471005512 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 446471005513 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 446471005514 active site 446471005515 DNA binding site [nucleotide binding] 446471005516 catalytic site [active] 446471005517 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 446471005518 NAD(P) binding site [chemical binding]; other site 446471005519 putative active site [active] 446471005520 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 446471005521 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471005522 ATP binding site [chemical binding]; other site 446471005523 putative Mg++ binding site [ion binding]; other site 446471005524 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471005525 nucleotide binding region [chemical binding]; other site 446471005526 ATP-binding site [chemical binding]; other site 446471005527 RQC domain; Region: RQC; cl09632 446471005528 HRDC domain; Region: HRDC; cl02578 446471005529 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446471005530 active site 446471005531 metal binding site [ion binding]; metal-binding site 446471005532 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 446471005533 putative deacylase active site [active] 446471005534 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446471005535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005536 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 446471005537 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446471005538 tetramer interface [polypeptide binding]; other site 446471005539 TPP-binding site [chemical binding]; other site 446471005540 heterodimer interface [polypeptide binding]; other site 446471005541 phosphorylation loop region [posttranslational modification] 446471005542 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446471005543 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446471005544 alpha subunit interface [polypeptide binding]; other site 446471005545 TPP binding site [chemical binding]; other site 446471005546 heterodimer interface [polypeptide binding]; other site 446471005547 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446471005548 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 446471005549 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446471005550 E3 interaction surface; other site 446471005551 lipoyl attachment site [posttranslational modification]; other site 446471005552 e3 binding domain; Region: E3_binding; pfam02817 446471005553 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 446471005554 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 446471005555 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 446471005556 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446471005557 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446471005558 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 446471005559 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446471005560 carboxyltransferase (CT) interaction site; other site 446471005561 biotinylation site [posttranslational modification]; other site 446471005562 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446471005563 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446471005564 active site 446471005565 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 446471005566 putative active site [active] 446471005567 putative catalytic site [active] 446471005568 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 446471005569 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 446471005570 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 446471005571 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446471005572 putative acyltransferase; Provisional; Region: PRK05790 446471005573 dimer interface [polypeptide binding]; other site 446471005574 active site 446471005575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471005576 non-specific DNA binding site [nucleotide binding]; other site 446471005577 salt bridge; other site 446471005578 sequence-specific DNA binding site [nucleotide binding]; other site 446471005579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471005580 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446471005581 putative substrate translocation pore; other site 446471005582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471005583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005584 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446471005585 Pup-ligase protein; Region: Pup_ligase; cl15463 446471005586 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446471005587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005588 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446471005589 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471005590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471005591 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446471005592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471005593 dimer interface [polypeptide binding]; other site 446471005594 conserved gate region; other site 446471005595 putative PBP binding loops; other site 446471005596 ABC-ATPase subunit interface; other site 446471005597 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471005598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471005599 dimer interface [polypeptide binding]; other site 446471005600 conserved gate region; other site 446471005601 putative PBP binding loops; other site 446471005602 ABC-ATPase subunit interface; other site 446471005603 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 446471005604 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 446471005605 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 446471005606 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471005607 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446471005608 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446471005609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446471005610 DNA-binding site [nucleotide binding]; DNA binding site 446471005611 UTRA domain; Region: UTRA; cl01230 446471005612 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 446471005613 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 446471005614 phosphate binding site [ion binding]; other site 446471005615 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446471005616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005617 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446471005618 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446471005619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005621 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446471005622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005623 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446471005624 NAD(P) binding site [chemical binding]; other site 446471005625 active site 446471005626 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446471005627 active site 446471005628 substrate binding site [chemical binding]; other site 446471005629 catalytic site [active] 446471005630 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 446471005631 Lsr2; Region: Lsr2; pfam11774 446471005632 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 446471005633 dimer interface [polypeptide binding]; other site 446471005634 catalytic triad [active] 446471005635 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 446471005636 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 446471005637 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 446471005638 dimer interface [polypeptide binding]; other site 446471005639 TPP-binding site [chemical binding]; other site 446471005640 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 446471005641 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 446471005642 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446471005643 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446471005644 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 446471005645 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 446471005646 dimer interface [polypeptide binding]; other site 446471005647 active site 446471005648 CoA binding pocket [chemical binding]; other site 446471005649 Phosphopantetheine attachment site; Region: PP-binding; cl09936 446471005650 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 446471005651 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 446471005652 dimer interface [polypeptide binding]; other site 446471005653 active site 446471005654 HIRAN domain; Region: HIRAN; cl07418 446471005655 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 446471005656 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446471005657 active site 446471005658 catalytic residues [active] 446471005659 metal binding site [ion binding]; metal-binding site 446471005660 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 446471005661 active site residue [active] 446471005662 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446471005663 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005664 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446471005665 Berberine and berberine like; Region: BBE; pfam08031 446471005666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471005667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471005668 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446471005669 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 446471005670 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446471005671 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 446471005672 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 446471005673 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471005674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471005675 dimer interface [polypeptide binding]; other site 446471005676 conserved gate region; other site 446471005677 putative PBP binding loops; other site 446471005678 ABC-ATPase subunit interface; other site 446471005679 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 446471005680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471005681 dimer interface [polypeptide binding]; other site 446471005682 conserved gate region; other site 446471005683 putative PBP binding loops; other site 446471005684 ABC-ATPase subunit interface; other site 446471005685 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471005686 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471005687 DNA binding site [nucleotide binding] 446471005688 domain linker motif; other site 446471005689 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 446471005690 putative dimerization interface [polypeptide binding]; other site 446471005691 putative ligand binding site [chemical binding]; other site 446471005692 DNA primase; Validated; Region: dnaG; PRK05667 446471005693 CHC2 zinc finger; Region: zf-CHC2; cl15369 446471005694 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 446471005695 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 446471005696 active site 446471005697 metal binding site [ion binding]; metal-binding site 446471005698 interdomain interaction site; other site 446471005699 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 446471005700 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 446471005701 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 446471005702 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446471005703 Zn2+ binding site [ion binding]; other site 446471005704 Mg2+ binding site [ion binding]; other site 446471005705 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446471005706 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471005707 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 446471005708 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446471005709 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471005710 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 446471005711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471005712 dimer interface [polypeptide binding]; other site 446471005713 conserved gate region; other site 446471005714 putative PBP binding loops; other site 446471005715 ABC-ATPase subunit interface; other site 446471005716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471005717 dimer interface [polypeptide binding]; other site 446471005718 conserved gate region; other site 446471005719 putative PBP binding loops; other site 446471005720 ABC-ATPase subunit interface; other site 446471005721 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471005722 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471005723 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471005724 DNA binding site [nucleotide binding] 446471005725 domain linker motif; other site 446471005726 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 446471005727 putative dimerization interface [polypeptide binding]; other site 446471005728 putative ligand binding site [chemical binding]; other site 446471005729 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 446471005730 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471005731 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 446471005732 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 446471005733 FMN binding site [chemical binding]; other site 446471005734 active site 446471005735 catalytic residues [active] 446471005736 substrate binding site [chemical binding]; other site 446471005737 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446471005738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471005739 putative substrate translocation pore; other site 446471005740 glycyl-tRNA synthetase; Provisional; Region: PRK04173 446471005741 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 446471005742 motif 1; other site 446471005743 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 446471005744 active site 446471005745 motif 2; other site 446471005746 motif 3; other site 446471005747 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 446471005748 anticodon binding site; other site 446471005749 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446471005750 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 446471005751 intersubunit interface [polypeptide binding]; other site 446471005752 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471005753 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471005754 Walker A/P-loop; other site 446471005755 ATP binding site [chemical binding]; other site 446471005756 Q-loop/lid; other site 446471005757 ABC transporter signature motif; other site 446471005758 Walker B; other site 446471005759 D-loop; other site 446471005760 H-loop/switch region; other site 446471005761 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446471005762 ABC-ATPase subunit interface; other site 446471005763 dimer interface [polypeptide binding]; other site 446471005764 putative PBP binding regions; other site 446471005765 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446471005766 metal binding site 2 [ion binding]; metal-binding site 446471005767 putative DNA binding helix; other site 446471005768 metal binding site 1 [ion binding]; metal-binding site 446471005769 dimer interface [polypeptide binding]; other site 446471005770 structural Zn2+ binding site [ion binding]; other site 446471005771 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446471005772 ABC-ATPase subunit interface; other site 446471005773 dimer interface [polypeptide binding]; other site 446471005774 putative PBP binding regions; other site 446471005775 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446471005776 ABC-ATPase subunit interface; other site 446471005777 dimer interface [polypeptide binding]; other site 446471005778 putative PBP binding regions; other site 446471005779 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446471005780 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446471005781 Walker A/P-loop; other site 446471005782 ATP binding site [chemical binding]; other site 446471005783 Q-loop/lid; other site 446471005784 ABC transporter signature motif; other site 446471005785 Walker B; other site 446471005786 D-loop; other site 446471005787 H-loop/switch region; other site 446471005788 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446471005789 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446471005790 siderophore binding site; other site 446471005791 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 446471005792 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 446471005793 catalytic residue [active] 446471005794 putative FPP diphosphate binding site; other site 446471005795 putative FPP binding hydrophobic cleft; other site 446471005796 dimer interface [polypeptide binding]; other site 446471005797 putative IPP diphosphate binding site; other site 446471005798 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 446471005799 Recombination protein O N terminal; Region: RecO_N; pfam11967 446471005800 Recombination protein O C terminal; Region: RecO_C; pfam02565 446471005801 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446471005802 oligomer interface [polypeptide binding]; other site 446471005803 active site residues [active] 446471005804 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446471005805 oligomer interface [polypeptide binding]; other site 446471005806 active site residues [active] 446471005807 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471005808 non-specific DNA binding site [nucleotide binding]; other site 446471005809 salt bridge; other site 446471005810 sequence-specific DNA binding site [nucleotide binding]; other site 446471005811 2-isopropylmalate synthase; Validated; Region: PRK03739 446471005812 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 446471005813 active site 446471005814 catalytic residues [active] 446471005815 metal binding site [ion binding]; metal-binding site 446471005816 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 446471005817 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446471005818 GTPase Era; Reviewed; Region: era; PRK00089 446471005819 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 446471005820 G1 box; other site 446471005821 GTP/Mg2+ binding site [chemical binding]; other site 446471005822 Switch I region; other site 446471005823 G2 box; other site 446471005824 Switch II region; other site 446471005825 G3 box; other site 446471005826 G4 box; other site 446471005827 G5 box; other site 446471005828 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 446471005829 Domain of unknown function DUF21; Region: DUF21; pfam01595 446471005830 FOG: CBS domain [General function prediction only]; Region: COG0517 446471005831 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446471005832 Transporter associated domain; Region: CorC_HlyC; cl08393 446471005833 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 446471005834 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 446471005835 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471005836 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 446471005837 nucleotide binding site/active site [active] 446471005838 HIT family signature motif; other site 446471005839 catalytic residue [active] 446471005840 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 446471005841 chaperone protein DnaJ; Provisional; Region: PRK14278 446471005842 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446471005843 HSP70 interaction site [polypeptide binding]; other site 446471005844 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 446471005845 Zn binding sites [ion binding]; other site 446471005846 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 446471005847 dimer interface [polypeptide binding]; other site 446471005848 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 446471005849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005850 HrcA protein C terminal domain; Region: HrcA; pfam01628 446471005851 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 446471005852 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 446471005853 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471005854 DNA binding residues [nucleotide binding] 446471005855 dimerization interface [polypeptide binding]; other site 446471005856 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 446471005857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 446471005858 coproporphyrinogen III oxidase; Validated; Region: PRK05628 446471005859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446471005860 FeS/SAM binding site; other site 446471005861 HemN C-terminal region; Region: HemN_C; pfam06969 446471005862 GTP-binding protein LepA; Provisional; Region: PRK05433 446471005863 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 446471005864 G1 box; other site 446471005865 putative GEF interaction site [polypeptide binding]; other site 446471005866 GTP/Mg2+ binding site [chemical binding]; other site 446471005867 Switch I region; other site 446471005868 G2 box; other site 446471005869 G3 box; other site 446471005870 Switch II region; other site 446471005871 G4 box; other site 446471005872 G5 box; other site 446471005873 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 446471005874 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 446471005875 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 446471005876 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 446471005877 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446471005878 DinB superfamily; Region: DinB_2; cl00986 446471005879 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 446471005880 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 446471005881 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 446471005882 Uncharacterized conserved protein [Function unknown]; Region: COG2308 446471005883 Domain of unknown function (DUF404); Region: DUF404; pfam04169 446471005884 Domain of unknown function (DUF407); Region: DUF407; pfam04174 446471005885 PemK-like protein; Region: PemK; cl00995 446471005886 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 446471005887 hypothetical protein; Reviewed; Region: PRK07914 446471005888 Competence protein; Region: Competence; cl00471 446471005889 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446471005890 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 446471005891 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 446471005892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005893 domain; Region: Succ_DH_flav_C; pfam02910 446471005894 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 446471005895 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 446471005896 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 446471005897 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471005898 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 446471005899 homodimer interface [polypeptide binding]; other site 446471005900 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 446471005901 active site pocket [active] 446471005902 MukB N-terminal; Region: MukB; pfam04310 446471005903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 446471005904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 446471005905 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 446471005906 aminoacyl-tRNA ligase; Region: PLN02563 446471005907 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471005908 active site 446471005909 HIGH motif; other site 446471005910 nucleotide binding site [chemical binding]; other site 446471005911 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471005912 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471005913 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471005914 active site 446471005915 KMSKS motif; other site 446471005916 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 446471005917 tRNA binding surface [nucleotide binding]; other site 446471005918 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446471005919 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446471005920 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 446471005921 active site 446471005922 catalytic tetrad [active] 446471005923 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446471005924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 446471005925 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 446471005926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005927 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 446471005928 FeoA domain; Region: FeoA; cl00838 446471005929 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446471005930 active site 446471005931 metal binding site [ion binding]; metal-binding site 446471005932 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446471005933 hydrophobic ligand binding site; other site 446471005934 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 446471005935 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 446471005936 putative DNA binding site [nucleotide binding]; other site 446471005937 putative homodimer interface [polypeptide binding]; other site 446471005938 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 446471005939 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 446471005940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471005941 non-specific DNA binding site [nucleotide binding]; other site 446471005942 salt bridge; other site 446471005943 sequence-specific DNA binding site [nucleotide binding]; other site 446471005944 Cupin domain; Region: Cupin_2; cl09118 446471005945 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446471005946 synthetase active site [active] 446471005947 NTP binding site [chemical binding]; other site 446471005948 metal binding site [ion binding]; metal-binding site 446471005949 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 446471005950 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 446471005951 nucleotide binding site [chemical binding]; other site 446471005952 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 446471005953 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 446471005954 active site 446471005955 DNA binding site [nucleotide binding] 446471005956 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 446471005957 DNA binding site [nucleotide binding] 446471005958 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446471005959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 446471005960 YCII-related domain; Region: YCII; cl00999 446471005961 YCII-related domain; Region: YCII; cl00999 446471005962 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 446471005963 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 446471005964 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 446471005965 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 446471005966 active site 446471005967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471005968 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446471005969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471005970 putative substrate translocation pore; other site 446471005971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005972 Predicted dehydrogenase [General function prediction only]; Region: COG0579 446471005973 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 446471005974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005975 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471005976 dimerization interface [polypeptide binding]; other site 446471005977 LysE type translocator; Region: LysE; cl00565 446471005978 Chitin binding domain; Region: Chitin_bind_3; cl03871 446471005979 Cellulose binding domain; Region: CBM_2; cl02709 446471005980 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 446471005981 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 446471005982 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 446471005983 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 446471005984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471005985 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 446471005986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471005987 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446471005988 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446471005989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446471005990 catalytic core [active] 446471005991 Domain of unknown function DUF143; Region: DUF143; cl00519 446471005992 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 446471005993 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 446471005994 active site 446471005995 (T/H)XGH motif; other site 446471005996 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 446471005997 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 446471005998 putative catalytic cysteine [active] 446471005999 benzoate transport; Region: 2A0115; TIGR00895 446471006000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471006001 putative substrate translocation pore; other site 446471006002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471006003 gamma-glutamyl kinase; Provisional; Region: PRK05429 446471006004 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 446471006005 nucleotide binding site [chemical binding]; other site 446471006006 homotetrameric interface [polypeptide binding]; other site 446471006007 putative phosphate binding site [ion binding]; other site 446471006008 putative allosteric binding site; other site 446471006009 PUA domain; Region: PUA; cl00607 446471006010 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 446471006011 GTPase CgtA; Reviewed; Region: obgE; PRK12296 446471006012 GTP1/OBG; Region: GTP1_OBG; pfam01018 446471006013 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 446471006014 G1 box; other site 446471006015 GTP/Mg2+ binding site [chemical binding]; other site 446471006016 Switch I region; other site 446471006017 G2 box; other site 446471006018 G3 box; other site 446471006019 Switch II region; other site 446471006020 G4 box; other site 446471006021 G5 box; other site 446471006022 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 446471006023 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 446471006024 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 446471006025 BCCT family transporter; Region: BCCT; cl00569 446471006026 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 446471006027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471006028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471006029 Thymidine kinase; Region: TK; cl00631 446471006030 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 446471006031 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 446471006032 homodimer interface [polypeptide binding]; other site 446471006033 oligonucleotide binding site [chemical binding]; other site 446471006034 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 446471006035 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446471006036 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446471006037 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 446471006038 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471006039 Walker A/P-loop; other site 446471006040 ATP binding site [chemical binding]; other site 446471006041 Q-loop/lid; other site 446471006042 ABC transporter signature motif; other site 446471006043 Walker B; other site 446471006044 D-loop; other site 446471006045 H-loop/switch region; other site 446471006046 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 446471006047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471006048 Walker A/P-loop; other site 446471006049 ATP binding site [chemical binding]; other site 446471006050 Q-loop/lid; other site 446471006051 ABC transporter signature motif; other site 446471006052 Walker B; other site 446471006053 D-loop; other site 446471006054 H-loop/switch region; other site 446471006055 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446471006056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006057 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 446471006058 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 446471006059 DNA binding site [nucleotide binding] 446471006060 catalytic residue [active] 446471006061 H2TH interface [polypeptide binding]; other site 446471006062 putative catalytic residues [active] 446471006063 turnover-facilitating residue; other site 446471006064 intercalation triad [nucleotide binding]; other site 446471006065 8OG recognition residue [nucleotide binding]; other site 446471006066 putative reading head residues; other site 446471006067 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446471006068 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446471006069 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 446471006070 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 446471006071 dimerization interface [polypeptide binding]; other site 446471006072 active site 446471006073 metal binding site [ion binding]; metal-binding site 446471006074 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 446471006075 dsRNA binding site [nucleotide binding]; other site 446471006076 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 446471006077 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 446471006078 Plant ATP synthase F0; Region: YMF19; cl07975 446471006079 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 446471006080 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471006081 active site 446471006082 nucleotide binding site [chemical binding]; other site 446471006083 HIGH motif; other site 446471006084 KMSKS motif; other site 446471006085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471006086 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 446471006087 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 446471006088 generic binding surface II; other site 446471006089 ssDNA binding site; other site 446471006090 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471006091 ATP binding site [chemical binding]; other site 446471006092 putative Mg++ binding site [ion binding]; other site 446471006093 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471006094 nucleotide binding region [chemical binding]; other site 446471006095 ATP-binding site [chemical binding]; other site 446471006096 DAK2 domain; Region: Dak2; cl03685 446471006097 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 446471006098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446471006099 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471006100 Coenzyme A binding pocket [chemical binding]; other site 446471006101 thiamine monophosphate kinase; Provisional; Region: PRK05731 446471006102 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 446471006103 ATP binding site [chemical binding]; other site 446471006104 dimerization interface [polypeptide binding]; other site 446471006105 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 446471006106 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 446471006107 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446471006108 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446471006109 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446471006110 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 446471006111 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 446471006112 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 446471006113 SUA5 domain; Region: SUA5; pfam03481 446471006114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446471006115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471006116 putative substrate translocation pore; other site 446471006117 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446471006118 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446471006119 conserved cys residue [active] 446471006120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446471006121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446471006122 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 446471006123 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446471006124 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446471006125 catalytic residue [active] 446471006126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006127 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 446471006128 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 446471006129 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446471006130 putative acyl-acceptor binding pocket; other site 446471006131 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 446471006132 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 446471006133 hinge; other site 446471006134 active site 446471006135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471006136 metabolite-proton symporter; Region: 2A0106; TIGR00883 446471006137 putative substrate translocation pore; other site 446471006138 glutamate dehydrogenase; Provisional; Region: PRK09414 446471006139 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 446471006140 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 446471006141 NAD(P) binding site [chemical binding]; other site 446471006142 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 446471006143 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 446471006144 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 446471006145 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 446471006146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15367 446471006147 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 446471006148 ATP cone domain; Region: ATP-cone; pfam03477 446471006149 Class III ribonucleotide reductase; Region: RNR_III; cd01675 446471006150 effector binding site; other site 446471006151 active site 446471006152 Zn binding site [ion binding]; other site 446471006153 glycine loop; other site 446471006154 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 446471006155 Domain of unknown function DUF; Region: DUF202; cl09954 446471006156 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 446471006157 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 446471006158 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 446471006159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471006160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471006161 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 446471006162 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446471006163 putative PBP binding regions; other site 446471006164 ABC-ATPase subunit interface; other site 446471006165 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446471006166 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446471006167 Walker A/P-loop; other site 446471006168 ATP binding site [chemical binding]; other site 446471006169 Q-loop/lid; other site 446471006170 ABC transporter signature motif; other site 446471006171 Walker B; other site 446471006172 D-loop; other site 446471006173 H-loop/switch region; other site 446471006174 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 446471006175 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446471006176 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446471006177 intersubunit interface [polypeptide binding]; other site 446471006178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471006179 PemK-like protein; Region: PemK; cl00995 446471006180 OsmC-like protein; Region: OsmC; cl00767 446471006181 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446471006182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471006183 ATP binding site [chemical binding]; other site 446471006184 putative Mg++ binding site [ion binding]; other site 446471006185 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 446471006186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471006187 ATP-binding site [chemical binding]; other site 446471006188 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 446471006189 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446471006190 putative active site [active] 446471006191 catalytic site [active] 446471006192 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 446471006193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471006194 ATP-binding site [chemical binding]; other site 446471006195 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 446471006196 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471006197 ATP binding site [chemical binding]; other site 446471006198 putative Mg++ binding site [ion binding]; other site 446471006199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471006200 nucleotide binding region [chemical binding]; other site 446471006201 ATP-binding site [chemical binding]; other site 446471006202 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471006203 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446471006204 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 446471006205 putative homodimer interface [polypeptide binding]; other site 446471006206 putative active site [active] 446471006207 catalytic site [active] 446471006208 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471006209 TrwC relaxase; Region: TrwC; cl08490 446471006210 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 446471006211 Protein of unknown function (DUF732); Region: DUF732; pfam05305 446471006212 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 446471006213 putative dimer interface [polypeptide binding]; other site 446471006214 catalytic triad [active] 446471006215 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471006216 Walker A motif; other site 446471006217 ATP binding site [chemical binding]; other site 446471006218 Walker B motif; other site 446471006219 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446471006220 dimer interface [polypeptide binding]; other site 446471006221 ssDNA binding site [nucleotide binding]; other site 446471006222 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446471006223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471006224 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471006225 Phage integrase family; Region: Phage_integrase; pfam00589 446471006226 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446471006227 Int/Topo IB signature motif; other site 446471006228 active site 446471006229 DNA binding site [nucleotide binding] 446471006230 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 446471006231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006233 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446471006234 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446471006235 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 446471006236 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446471006237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446471006238 DNA-binding site [nucleotide binding]; DNA binding site 446471006239 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 446471006240 substrate binding site [chemical binding]; other site 446471006241 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 446471006242 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 446471006243 substrate binding site [chemical binding]; other site 446471006244 ligand binding site [chemical binding]; other site 446471006245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471006246 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446471006247 Bacterial transcriptional regulator; Region: IclR; pfam01614 446471006248 Bacterial membrane flanked domain; Region: DUF304; cl01348 446471006249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446471006250 S-adenosylmethionine binding site [chemical binding]; other site 446471006251 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 446471006252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446471006253 motif II; other site 446471006254 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 446471006255 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471006256 active site 446471006257 HIGH motif; other site 446471006258 nucleotide binding site [chemical binding]; other site 446471006259 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 446471006260 active site 446471006261 KMSKS motif; other site 446471006262 Predicted transcriptional regulator [Transcription]; Region: COG5340 446471006263 magnesium protoporphyrin O-methyltransferase; Region: BchM-ChlM; TIGR02021 446471006264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471006265 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 446471006266 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 446471006267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446471006268 S-adenosylmethionine binding site [chemical binding]; other site 446471006269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006271 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471006272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471006273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471006274 ski2-like helicase; Provisional; Region: PRK02362 446471006275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471006276 ATP binding site [chemical binding]; other site 446471006277 putative Mg++ binding site [ion binding]; other site 446471006278 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471006279 nucleotide binding region [chemical binding]; other site 446471006280 ATP-binding site [chemical binding]; other site 446471006281 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 446471006282 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 446471006283 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 446471006284 putative deacylase active site [active] 446471006285 hypothetical protein; Provisional; Region: PRK11770 446471006286 Domain of unknown function (DUF307); Region: DUF307; pfam03733 446471006287 Domain of unknown function (DUF307); Region: DUF307; pfam03733 446471006288 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 446471006289 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446471006290 catalytic residue [active] 446471006291 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 446471006292 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 446471006293 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 446471006294 EamA-like transporter family; Region: EamA; cl01037 446471006295 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 446471006296 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 446471006297 active site 446471006298 catalytic residues [active] 446471006299 metal binding site [ion binding]; metal-binding site 446471006300 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 446471006301 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 446471006302 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 446471006303 homodimer interface [polypeptide binding]; other site 446471006304 substrate-cofactor binding pocket; other site 446471006305 catalytic residue [active] 446471006306 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 446471006307 ketol-acid reductoisomerase; Provisional; Region: PRK05479 446471006308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006309 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 446471006310 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 446471006311 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 446471006312 putative valine binding site [chemical binding]; other site 446471006313 dimer interface [polypeptide binding]; other site 446471006314 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 446471006315 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 446471006316 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446471006317 PYR/PP interface [polypeptide binding]; other site 446471006318 dimer interface [polypeptide binding]; other site 446471006319 TPP binding site [chemical binding]; other site 446471006320 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 446471006321 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 446471006322 TPP-binding site [chemical binding]; other site 446471006323 dimer interface [polypeptide binding]; other site 446471006324 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 446471006325 aromatic arch; other site 446471006326 DCoH dimer interaction site [polypeptide binding]; other site 446471006327 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 446471006328 DCoH tetramer interaction site [polypeptide binding]; other site 446471006329 substrate binding site [chemical binding]; other site 446471006330 Dehydratase family; Region: ILVD_EDD; cl00340 446471006331 Dehydratase family; Region: ILVD_EDD; cl00340 446471006332 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446471006333 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471006334 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 446471006335 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 446471006336 GatB domain; Region: GatB_Yqey; cl11497 446471006337 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446471006338 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 446471006339 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 446471006340 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471006341 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446471006342 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 446471006343 Metal-binding active site; metal-binding site 446471006344 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 446471006345 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446471006346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006347 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446471006348 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 446471006349 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446471006350 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446471006351 TM-ABC transporter signature motif; other site 446471006352 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446471006353 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 446471006354 Walker A/P-loop; other site 446471006355 ATP binding site [chemical binding]; other site 446471006356 Q-loop/lid; other site 446471006357 ABC transporter signature motif; other site 446471006358 Walker B; other site 446471006359 D-loop; other site 446471006360 H-loop/switch region; other site 446471006361 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 446471006362 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446471006363 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446471006364 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446471006365 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 446471006366 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 446471006367 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 446471006368 nucleotide binding pocket [chemical binding]; other site 446471006369 K-X-D-G motif; other site 446471006370 catalytic site [active] 446471006371 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 446471006372 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 446471006373 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 446471006374 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 446471006375 putative catalytic cysteine [active] 446471006376 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 446471006377 putative active site [active] 446471006378 metal binding site [ion binding]; metal-binding site 446471006379 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 446471006380 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471006381 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 446471006382 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 446471006383 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 446471006384 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 446471006385 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446471006386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446471006387 catalytic residue [active] 446471006388 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 446471006389 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 446471006390 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446471006391 Ligand Binding Site [chemical binding]; other site 446471006392 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 446471006393 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 446471006394 Ligand binding site [chemical binding]; other site 446471006395 Electron transfer flavoprotein domain; Region: ETF; pfam01012 446471006396 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 446471006397 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 446471006398 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471006399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006400 FAD binding domain; Region: FAD_binding_2; pfam00890 446471006401 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446471006402 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471006403 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 446471006404 active site 446471006405 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 446471006406 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471006407 trehalose synthase; Region: treS_nterm; TIGR02456 446471006408 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471006409 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 446471006410 Permease family; Region: Xan_ur_permease; cl00967 446471006411 glycogen branching enzyme; Provisional; Region: PRK05402 446471006412 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 446471006413 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471006414 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 446471006415 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 446471006416 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 446471006417 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471006418 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 446471006419 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 446471006420 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 446471006421 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 446471006422 phosphoglycerate mutase; Provisional; Region: PTZ00122 446471006423 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446471006424 catalytic core [active] 446471006425 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 446471006426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446471006427 motif II; other site 446471006428 Phosphotransferase enzyme family; Region: APH; pfam01636 446471006429 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446471006430 active site 446471006431 ATP binding site [chemical binding]; other site 446471006432 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 446471006433 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 446471006434 dimer interface [polypeptide binding]; other site 446471006435 putative radical transfer pathway; other site 446471006436 diiron center [ion binding]; other site 446471006437 tyrosyl radical; other site 446471006438 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 446471006439 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 446471006440 Class I ribonucleotide reductase; Region: RNR_I; cd01679 446471006441 active site 446471006442 dimer interface [polypeptide binding]; other site 446471006443 catalytic residues [active] 446471006444 effector binding site; other site 446471006445 R2 peptide binding site; other site 446471006446 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 446471006447 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 446471006448 catalytic residues [active] 446471006449 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446471006450 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 446471006451 Cellulose binding domain; Region: CBM_2; cl02709 446471006452 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446471006453 active site 446471006454 short chain dehydrogenase; Provisional; Region: PRK06197 446471006455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006456 NAD(P) binding site [chemical binding]; other site 446471006457 active site 446471006458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471006459 Protein of unknown function DUF91; Region: DUF91; cl00709 446471006460 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 446471006461 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 446471006462 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 446471006463 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 446471006464 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 446471006465 alpha subunit interaction interface [polypeptide binding]; other site 446471006466 Walker A motif; other site 446471006467 ATP binding site [chemical binding]; other site 446471006468 Walker B motif; other site 446471006469 inhibitor binding site; inhibition site 446471006470 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446471006471 ATP synthase; Region: ATP-synt; cl00365 446471006472 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 446471006473 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 446471006474 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 446471006475 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 446471006476 beta subunit interaction interface [polypeptide binding]; other site 446471006477 Walker A motif; other site 446471006478 ATP binding site [chemical binding]; other site 446471006479 Walker B motif; other site 446471006480 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446471006481 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 446471006482 Plant ATP synthase F0; Region: YMF19; cl07975 446471006483 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 446471006484 ATP synthase subunit C; Region: ATP-synt_C; cl00466 446471006485 ATP synthase A chain; Region: ATP-synt_A; cl00413 446471006486 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 446471006487 Mg++ binding site [ion binding]; other site 446471006488 putative catalytic motif [active] 446471006489 substrate binding site [chemical binding]; other site 446471006490 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 446471006491 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 446471006492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471006493 peptide chain release factor 1; Validated; Region: prfA; PRK00591 446471006494 RF-1 domain; Region: RF-1; cl02875 446471006495 RF-1 domain; Region: RF-1; cl02875 446471006496 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 446471006497 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446471006498 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446471006499 transcription termination factor Rho; Provisional; Region: PRK12678 446471006500 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 446471006501 transcription termination factor Rho; Provisional; Region: PRK12608 446471006502 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446471006503 RNA binding site [nucleotide binding]; other site 446471006504 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 446471006505 multimer interface [polypeptide binding]; other site 446471006506 Walker A motif; other site 446471006507 ATP binding site [chemical binding]; other site 446471006508 Walker B motif; other site 446471006509 homoserine kinase; Provisional; Region: PRK01212 446471006510 threonine synthase; Reviewed; Region: PRK06721 446471006511 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 446471006512 homodimer interface [polypeptide binding]; other site 446471006513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471006514 catalytic residue [active] 446471006515 homoserine dehydrogenase; Provisional; Region: PRK06349 446471006516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006517 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 446471006518 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 446471006519 diaminopimelate decarboxylase; Region: lysA; TIGR01048 446471006520 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 446471006521 active site 446471006522 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446471006523 substrate binding site [chemical binding]; other site 446471006524 catalytic residues [active] 446471006525 dimer interface [polypeptide binding]; other site 446471006526 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 446471006527 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 446471006528 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471006529 active site 446471006530 HIGH motif; other site 446471006531 nucleotide binding site [chemical binding]; other site 446471006532 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 446471006533 KMSK motif region; other site 446471006534 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446471006535 anticodon binding site; other site 446471006536 tRNA binding surface [nucleotide binding]; other site 446471006537 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 446471006538 Phd_YefM; Region: PhdYeFM; cl09153 446471006539 Chitin binding domain; Region: Chitin_bind_3; cl03871 446471006540 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446471006541 Interdomain contacts; other site 446471006542 Cytokine receptor motif; other site 446471006543 Cellulose binding domain; Region: CBM_2; cl02709 446471006544 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446471006545 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446471006546 TM-ABC transporter signature motif; other site 446471006547 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446471006548 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 446471006549 Walker A/P-loop; other site 446471006550 ATP binding site [chemical binding]; other site 446471006551 Q-loop/lid; other site 446471006552 ABC transporter signature motif; other site 446471006553 Walker B; other site 446471006554 D-loop; other site 446471006555 H-loop/switch region; other site 446471006556 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446471006557 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471006558 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446471006559 DNA binding residues [nucleotide binding] 446471006560 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446471006561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446471006562 DNA-binding site [nucleotide binding]; DNA binding site 446471006563 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 446471006564 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 446471006565 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446471006566 tetramer interface [polypeptide binding]; other site 446471006567 active site 446471006568 Mg2+/Mn2+ binding site [ion binding]; other site 446471006569 citrate synthase; Provisional; Region: PRK14033 446471006570 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 446471006571 oxalacetate binding site [chemical binding]; other site 446471006572 citrylCoA binding site [chemical binding]; other site 446471006573 coenzyme A binding site [chemical binding]; other site 446471006574 catalytic triad [active] 446471006575 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 446471006576 putative active site [active] 446471006577 putative metal binding residues [ion binding]; other site 446471006578 signature motif; other site 446471006579 putative dimer interface [polypeptide binding]; other site 446471006580 putative phosphate binding site [ion binding]; other site 446471006581 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 446471006582 Domain of unknown function DUF21; Region: DUF21; pfam01595 446471006583 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446471006584 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446471006585 Domain of unknown function DUF21; Region: DUF21; pfam01595 446471006586 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446471006587 Transporter associated domain; Region: CorC_HlyC; cl08393 446471006588 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446471006589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471006590 active site 446471006591 phosphorylation site [posttranslational modification] 446471006592 intermolecular recognition site; other site 446471006593 dimerization interface [polypeptide binding]; other site 446471006594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446471006595 DNA binding site [nucleotide binding] 446471006596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446471006597 dimerization interface [polypeptide binding]; other site 446471006598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446471006599 dimer interface [polypeptide binding]; other site 446471006600 phosphorylation site [posttranslational modification] 446471006601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471006602 ATP binding site [chemical binding]; other site 446471006603 Mg2+ binding site [ion binding]; other site 446471006604 G-X-G motif; other site 446471006605 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 446471006606 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 446471006607 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 446471006608 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 446471006609 TPP-binding site [chemical binding]; other site 446471006610 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 446471006611 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 446471006612 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446471006613 active site 446471006614 catalytic tetrad [active] 446471006615 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 446471006616 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 446471006617 active site 446471006618 catalytic residues [active] 446471006619 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446471006620 active site 446471006621 catalytic triad [active] 446471006622 oxyanion hole [active] 446471006623 Anti-sigma-K factor rskA; Region: RskA; cl15366 446471006624 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 446471006625 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471006626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446471006627 DNA binding residues [nucleotide binding] 446471006628 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 446471006629 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 446471006630 hinge; other site 446471006631 active site 446471006632 Predicted GTPases [General function prediction only]; Region: COG1162 446471006633 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 446471006634 GTPase/OB domain interface [polypeptide binding]; other site 446471006635 GTPase/Zn-binding domain interface [polypeptide binding]; other site 446471006636 GTP/Mg2+ binding site [chemical binding]; other site 446471006637 G4 box; other site 446471006638 G5 box; other site 446471006639 G1 box; other site 446471006640 Switch I region; other site 446471006641 G2 box; other site 446471006642 G3 box; other site 446471006643 Switch II region; other site 446471006644 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 446471006645 active site 446471006646 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 446471006647 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 446471006648 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471006649 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 446471006650 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 446471006651 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471006652 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 446471006653 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471006654 nucleotide binding region [chemical binding]; other site 446471006655 SEC-C motif; Region: SEC-C; pfam02810 446471006656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 446471006657 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446471006658 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 446471006659 30S subunit binding site; other site 446471006660 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446471006661 FtsX-like permease family; Region: FtsX; pfam02687 446471006662 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471006663 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471006664 Walker A/P-loop; other site 446471006665 ATP binding site [chemical binding]; other site 446471006666 Q-loop/lid; other site 446471006667 ABC transporter signature motif; other site 446471006668 Walker B; other site 446471006669 D-loop; other site 446471006670 H-loop/switch region; other site 446471006671 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 446471006672 lipoprotein LpqB; Provisional; Region: PRK13614 446471006673 Sporulation and spore germination; Region: Germane; cl11253 446471006674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 446471006675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446471006676 dimer interface [polypeptide binding]; other site 446471006677 phosphorylation site [posttranslational modification] 446471006678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471006679 ATP binding site [chemical binding]; other site 446471006680 Mg2+ binding site [ion binding]; other site 446471006681 G-X-G motif; other site 446471006682 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446471006683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471006684 active site 446471006685 phosphorylation site [posttranslational modification] 446471006686 intermolecular recognition site; other site 446471006687 dimerization interface [polypeptide binding]; other site 446471006688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446471006689 DNA binding site [nucleotide binding] 446471006690 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 446471006691 MoxR-like ATPases [General function prediction only]; Region: COG0714 446471006692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471006693 Walker A motif; other site 446471006694 ATP binding site [chemical binding]; other site 446471006695 Walker B motif; other site 446471006696 arginine finger; other site 446471006697 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446471006698 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446471006699 Clostridial hydrophobic W; Region: ChW; cl02763 446471006700 Clostridial hydrophobic W; Region: ChW; cl02763 446471006701 Clostridial hydrophobic W; Region: ChW; cl02763 446471006702 Clostridial hydrophobic W; Region: ChW; cl02763 446471006703 Clostridial hydrophobic W; Region: ChW; cl02763 446471006704 Clostridial hydrophobic W; Region: ChW; cl02763 446471006705 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 446471006706 Integral membrane protein DUF95; Region: DUF95; cl00572 446471006707 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471006708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471006709 active site 446471006710 phosphorylation site [posttranslational modification] 446471006711 intermolecular recognition site; other site 446471006712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471006713 DNA binding residues [nucleotide binding] 446471006714 dimerization interface [polypeptide binding]; other site 446471006715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446471006716 Histidine kinase; Region: HisKA_3; pfam07730 446471006717 Adenosylhomocysteinase; Provisional; Region: PTZ00075 446471006718 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 446471006719 oligomerization interface [polypeptide binding]; other site 446471006720 active site 446471006721 NAD+ binding site [chemical binding]; other site 446471006722 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 446471006723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471006724 putative substrate translocation pore; other site 446471006725 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 446471006726 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 446471006727 Walker A/P-loop; other site 446471006728 ATP binding site [chemical binding]; other site 446471006729 Q-loop/lid; other site 446471006730 ABC transporter signature motif; other site 446471006731 Walker B; other site 446471006732 D-loop; other site 446471006733 H-loop/switch region; other site 446471006734 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 446471006735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471006736 dimer interface [polypeptide binding]; other site 446471006737 conserved gate region; other site 446471006738 putative PBP binding loops; other site 446471006739 ABC-ATPase subunit interface; other site 446471006740 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 446471006741 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 446471006742 SAF domain; Region: SAF; cl00555 446471006743 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 446471006744 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 446471006745 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471006746 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471006747 DNA binding site [nucleotide binding] 446471006748 domain linker motif; other site 446471006749 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446471006750 ligand binding site [chemical binding]; other site 446471006751 dimerization interface [polypeptide binding]; other site 446471006752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446471006753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471006754 dimer interface [polypeptide binding]; other site 446471006755 putative PBP binding loops; other site 446471006756 ABC-ATPase subunit interface; other site 446471006757 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471006758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471006759 dimer interface [polypeptide binding]; other site 446471006760 conserved gate region; other site 446471006761 putative PBP binding loops; other site 446471006762 ABC-ATPase subunit interface; other site 446471006763 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471006764 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471006765 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 446471006766 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 446471006767 NADP binding site [chemical binding]; other site 446471006768 homodimer interface [polypeptide binding]; other site 446471006769 active site 446471006770 KduI/IolB family; Region: KduI; cl01508 446471006771 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 446471006772 Trm112p-like protein; Region: Trm112p; cl01066 446471006773 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 446471006774 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 446471006775 active site 446471006776 substrate binding site [chemical binding]; other site 446471006777 metal binding site [ion binding]; metal-binding site 446471006778 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 446471006779 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 446471006780 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 446471006781 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 446471006782 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446471006783 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471006784 active site 446471006785 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471006786 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446471006787 Transcription factor WhiB; Region: Whib; pfam02467 446471006788 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 446471006789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446471006790 S-adenosylmethionine binding site [chemical binding]; other site 446471006791 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446471006792 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446471006793 Ligand binding site; other site 446471006794 Putative Catalytic site; other site 446471006795 DXD motif; other site 446471006796 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 446471006797 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 446471006798 substrate binding site; other site 446471006799 tetramer interface; other site 446471006800 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446471006801 amidase catalytic site [active] 446471006802 Zn binding residues [ion binding]; other site 446471006803 substrate binding site [chemical binding]; other site 446471006804 Clostridial hydrophobic W; Region: ChW; cl02763 446471006805 Clostridial hydrophobic W; Region: ChW; cl02763 446471006806 Clostridial hydrophobic W; Region: ChW; cl02763 446471006807 Clostridial hydrophobic W; Region: ChW; cl02763 446471006808 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 446471006809 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 446471006810 NADP binding site [chemical binding]; other site 446471006811 active site 446471006812 putative substrate binding site [chemical binding]; other site 446471006813 Cupin domain; Region: Cupin_2; cl09118 446471006814 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446471006815 amidase catalytic site [active] 446471006816 Zn binding residues [ion binding]; other site 446471006817 substrate binding site [chemical binding]; other site 446471006818 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 446471006819 Clostridial hydrophobic W; Region: ChW; cl02763 446471006820 Clostridial hydrophobic W; Region: ChW; cl02763 446471006821 Clostridial hydrophobic W; Region: ChW; cl02763 446471006822 Clostridial hydrophobic W; Region: ChW; cl02763 446471006823 Clostridial hydrophobic W; Region: ChW; cl02763 446471006824 Clostridial hydrophobic W; Region: ChW; cl02763 446471006825 Stage II sporulation protein; Region: SpoIID; pfam08486 446471006826 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 446471006827 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 446471006828 Clostridial hydrophobic W; Region: ChW; cl02763 446471006829 Clostridial hydrophobic W; Region: ChW; cl02763 446471006830 Clostridial hydrophobic W; Region: ChW; cl02763 446471006831 Clostridial hydrophobic W; Region: ChW; cl02763 446471006832 Clostridial hydrophobic W; Region: ChW; cl02763 446471006833 Clostridial hydrophobic W; Region: ChW; cl02763 446471006834 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 446471006835 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 446471006836 NAD binding site [chemical binding]; other site 446471006837 substrate binding site [chemical binding]; other site 446471006838 homodimer interface [polypeptide binding]; other site 446471006839 active site 446471006840 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471006841 active site 446471006842 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471006843 active site 446471006844 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471006845 active site 446471006846 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446471006847 Ligand binding site; other site 446471006848 Putative Catalytic site; other site 446471006849 DXD motif; other site 446471006850 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 446471006851 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 446471006852 Walker A/P-loop; other site 446471006853 ATP binding site [chemical binding]; other site 446471006854 Q-loop/lid; other site 446471006855 ABC transporter signature motif; other site 446471006856 Walker B; other site 446471006857 D-loop; other site 446471006858 H-loop/switch region; other site 446471006859 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446471006860 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446471006861 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471006862 active site 446471006863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006864 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 446471006865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006866 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 446471006867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471006868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471006869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 446471006870 Integrase core domain; Region: rve; cl01316 446471006871 transposase; Provisional; Region: PRK06526 446471006872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471006873 Walker A motif; other site 446471006874 ATP binding site [chemical binding]; other site 446471006875 Walker B motif; other site 446471006876 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446471006877 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 446471006878 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446471006879 active site 446471006880 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 446471006881 Probable Catalytic site; other site 446471006882 metal-binding site 446471006883 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446471006884 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446471006885 active site 446471006886 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446471006887 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446471006888 active site 446471006889 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446471006890 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446471006891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471006892 active site 446471006893 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 446471006894 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 446471006895 Walker A/P-loop; other site 446471006896 ATP binding site [chemical binding]; other site 446471006897 Q-loop/lid; other site 446471006898 ABC transporter signature motif; other site 446471006899 Walker B; other site 446471006900 D-loop; other site 446471006901 H-loop/switch region; other site 446471006902 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446471006903 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471006904 active site 446471006905 nucleotide binding site [chemical binding]; other site 446471006906 HIGH motif; other site 446471006907 KMSKS motif; other site 446471006908 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446471006909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471006910 LicD family; Region: LicD; cl01378 446471006911 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446471006912 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446471006913 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446471006914 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446471006915 Ligand binding site; other site 446471006916 Putative Catalytic site; other site 446471006917 DXD motif; other site 446471006918 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 446471006919 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446471006920 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446471006921 AIR carboxylase; Region: AIRC; cl00310 446471006922 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 446471006923 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446471006924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 446471006925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446471006926 dimer interface [polypeptide binding]; other site 446471006927 phosphorylation site [posttranslational modification] 446471006928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471006929 Mg2+ binding site [ion binding]; other site 446471006930 G-X-G motif; other site 446471006931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446471006932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471006933 active site 446471006934 phosphorylation site [posttranslational modification] 446471006935 intermolecular recognition site; other site 446471006936 dimerization interface [polypeptide binding]; other site 446471006937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446471006938 DNA binding site [nucleotide binding] 446471006939 Histidine kinase; Region: HisKA_3; pfam07730 446471006940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446471006941 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471006942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471006943 active site 446471006944 phosphorylation site [posttranslational modification] 446471006945 intermolecular recognition site; other site 446471006946 dimerization interface [polypeptide binding]; other site 446471006947 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471006948 DNA binding residues [nucleotide binding] 446471006949 dimerization interface [polypeptide binding]; other site 446471006950 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471006951 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471006952 Walker A/P-loop; other site 446471006953 ATP binding site [chemical binding]; other site 446471006954 Q-loop/lid; other site 446471006955 ABC transporter signature motif; other site 446471006956 Walker B; other site 446471006957 D-loop; other site 446471006958 H-loop/switch region; other site 446471006959 FtsX-like permease family; Region: FtsX; pfam02687 446471006960 FtsX-like permease family; Region: FtsX; pfam02687 446471006961 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 446471006962 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471006963 Transcription factor WhiB; Region: Whib; pfam02467 446471006964 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 446471006965 PAS fold; Region: PAS_4; pfam08448 446471006966 Histidine kinase; Region: HisKA_2; cl06527 446471006967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471006968 ATP binding site [chemical binding]; other site 446471006969 Mg2+ binding site [ion binding]; other site 446471006970 G-X-G motif; other site 446471006971 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 446471006972 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471006973 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471006974 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446471006975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471006976 dimer interface [polypeptide binding]; other site 446471006977 conserved gate region; other site 446471006978 putative PBP binding loops; other site 446471006979 ABC-ATPase subunit interface; other site 446471006980 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471006981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471006982 dimer interface [polypeptide binding]; other site 446471006983 conserved gate region; other site 446471006984 ABC-ATPase subunit interface; other site 446471006985 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446471006986 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471006987 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471006988 DNA binding site [nucleotide binding] 446471006989 domain linker motif; other site 446471006990 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446471006991 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 446471006992 Putative carbohydrate binding domain; Region: CBM_X; cl05621 446471006993 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 446471006994 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 446471006995 Proline dehydrogenase; Region: Pro_dh; cl03282 446471006996 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446471006997 NAD(P) binding site [chemical binding]; other site 446471006998 catalytic residues [active] 446471006999 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446471007000 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 446471007001 active site 446471007002 catalytic tetrad [active] 446471007003 Phd_YefM; Region: PhdYeFM; cl09153 446471007004 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 446471007005 oligomeric interface; other site 446471007006 putative active site [active] 446471007007 homodimer interface [polypeptide binding]; other site 446471007008 glutamate dehydrogenase; Region: PLN02477 446471007009 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 446471007010 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 446471007011 NAD(P) binding site [chemical binding]; other site 446471007012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471007013 Chlorite dismutase; Region: Chlor_dismutase; cl01280 446471007014 ferrochelatase; Reviewed; Region: hemH; PRK00035 446471007015 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 446471007016 C-terminal domain interface [polypeptide binding]; other site 446471007017 active site 446471007018 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 446471007019 active site 446471007020 N-terminal domain interface [polypeptide binding]; other site 446471007021 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 446471007022 putative trimer interface [polypeptide binding]; other site 446471007023 putative CoA binding site [chemical binding]; other site 446471007024 Glycerate kinase family; Region: Gly_kinase; cl00841 446471007025 Transport protein; Region: actII; TIGR00833 446471007026 Transport protein; Region: actII; TIGR00833 446471007027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471007028 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 446471007029 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 446471007030 catalytic residue [active] 446471007031 putative FPP diphosphate binding site; other site 446471007032 putative FPP binding hydrophobic cleft; other site 446471007033 dimer interface [polypeptide binding]; other site 446471007034 putative IPP diphosphate binding site; other site 446471007035 Haemolysin-III related; Region: HlyIII; cl03831 446471007036 Predicted amidohydrolase [General function prediction only]; Region: COG0388 446471007037 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 446471007038 putative active site [active] 446471007039 catalytic triad [active] 446471007040 putative dimer interface [polypeptide binding]; other site 446471007041 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446471007042 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 446471007043 domain; Region: GreA_GreB_N; pfam03449 446471007044 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 446471007045 threonine dehydratase; Provisional; Region: PRK08198 446471007046 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 446471007047 tetramer interface [polypeptide binding]; other site 446471007048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471007049 catalytic residue [active] 446471007050 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 446471007051 Domain of unknown function DUF20; Region: UPF0118; cl00465 446471007052 cystathionine gamma-synthase; Provisional; Region: PRK07811 446471007053 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446471007054 homodimer interface [polypeptide binding]; other site 446471007055 substrate-cofactor binding pocket; other site 446471007056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471007057 catalytic residue [active] 446471007058 Protein of unknown function (DUF419); Region: DUF419; cl15265 446471007059 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 446471007060 Cupin domain; Region: Cupin_2; cl09118 446471007061 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 446471007062 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 446471007063 active site 446471007064 DNA binding site [nucleotide binding] 446471007065 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 446471007066 DNA binding site [nucleotide binding] 446471007067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471007068 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471007069 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471007070 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446471007071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007072 dimer interface [polypeptide binding]; other site 446471007073 conserved gate region; other site 446471007074 putative PBP binding loops; other site 446471007075 ABC-ATPase subunit interface; other site 446471007076 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471007077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007078 dimer interface [polypeptide binding]; other site 446471007079 conserved gate region; other site 446471007080 putative PBP binding loops; other site 446471007081 ABC-ATPase subunit interface; other site 446471007082 Glucuronate isomerase; Region: UxaC; cl00829 446471007083 TIR domain; Region: TIR; cl02060 446471007084 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446471007085 active site 446471007086 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 446471007087 N- and C-terminal domain interface [polypeptide binding]; other site 446471007088 catalytic site [active] 446471007089 metal binding site [ion binding]; metal-binding site 446471007090 carbohydrate binding site [chemical binding]; other site 446471007091 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 446471007092 MgATP binding site [chemical binding]; other site 446471007093 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 446471007094 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 446471007095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471007096 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 446471007097 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471007098 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471007099 DNA binding site [nucleotide binding] 446471007100 domain linker motif; other site 446471007101 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 446471007102 putative dimerization interface [polypeptide binding]; other site 446471007103 putative ligand binding site [chemical binding]; other site 446471007104 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446471007105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007106 dimer interface [polypeptide binding]; other site 446471007107 conserved gate region; other site 446471007108 putative PBP binding loops; other site 446471007109 ABC-ATPase subunit interface; other site 446471007110 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471007111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007112 dimer interface [polypeptide binding]; other site 446471007113 ABC-ATPase subunit interface; other site 446471007114 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471007115 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 446471007116 Protein of unknown function, DUF624; Region: DUF624; cl02369 446471007117 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 446471007118 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446471007119 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 446471007120 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 446471007121 mannonate dehydratase; Region: uxuA; TIGR00695 446471007122 mannonate dehydratase; Provisional; Region: PRK03906 446471007123 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 446471007124 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446471007125 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 446471007126 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 446471007127 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446471007128 dimer interface [polypeptide binding]; other site 446471007129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471007130 catalytic residue [active] 446471007131 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 446471007132 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 446471007133 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446471007134 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 446471007135 Walker A/P-loop; other site 446471007136 ATP binding site [chemical binding]; other site 446471007137 Q-loop/lid; other site 446471007138 ABC transporter signature motif; other site 446471007139 Walker B; other site 446471007140 D-loop; other site 446471007141 H-loop/switch region; other site 446471007142 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446471007143 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446471007144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471007145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471007146 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 446471007147 Protein of unknown function (DUF501); Region: DUF501; cl00652 446471007148 Septum formation initiator; Region: DivIC; cl11433 446471007149 enolase; Provisional; Region: eno; PRK00077 446471007150 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 446471007151 dimer interface [polypeptide binding]; other site 446471007152 metal binding site [ion binding]; metal-binding site 446471007153 substrate binding pocket [chemical binding]; other site 446471007154 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 446471007155 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 446471007156 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 446471007157 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 446471007158 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 446471007159 Ca binding site [ion binding]; other site 446471007160 carbohydrate binding site [chemical binding]; other site 446471007161 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 446471007162 chitin/cellulose binding site [chemical binding]; other site 446471007163 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 446471007164 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 446471007165 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 446471007166 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 446471007167 Ca binding site [ion binding]; other site 446471007168 carbohydrate binding site [chemical binding]; other site 446471007169 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 446471007170 chitin/cellulose binding site [chemical binding]; other site 446471007171 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 446471007172 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 446471007173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471007174 ATP binding site [chemical binding]; other site 446471007175 putative Mg++ binding site [ion binding]; other site 446471007176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471007177 nucleotide binding region [chemical binding]; other site 446471007178 ATP-binding site [chemical binding]; other site 446471007179 TRCF domain; Region: TRCF; cl04088 446471007180 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446471007181 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 446471007182 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 446471007183 putative trimer interface [polypeptide binding]; other site 446471007184 putative active site [active] 446471007185 putative substrate binding site [chemical binding]; other site 446471007186 putative CoA binding site [chemical binding]; other site 446471007187 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 446471007188 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471007189 active site 446471007190 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 446471007191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471007192 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446471007193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471007194 active site 446471007195 Protein of unknown function (DUF3118); Region: DUF3118; pfam11316 446471007196 O-Antigen ligase; Region: Wzy_C; cl04850 446471007197 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446471007198 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471007199 active site 446471007200 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 446471007201 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446471007202 inhibitor-cofactor binding pocket; inhibition site 446471007203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471007204 catalytic residue [active] 446471007205 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446471007206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471007207 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 446471007208 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 446471007209 putative active site [active] 446471007210 catalytic residue [active] 446471007211 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 446471007212 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 446471007213 5S rRNA interface [nucleotide binding]; other site 446471007214 CTC domain interface [polypeptide binding]; other site 446471007215 L16 interface [polypeptide binding]; other site 446471007216 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446471007217 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 446471007218 Ligand binding site; other site 446471007219 Putative Catalytic site; other site 446471007220 DXD motif; other site 446471007221 GtrA-like protein; Region: GtrA; cl00971 446471007222 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 446471007223 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446471007224 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 446471007225 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 446471007226 Substrate binding site; other site 446471007227 Mg++ binding site; other site 446471007228 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 446471007229 active site 446471007230 substrate binding site [chemical binding]; other site 446471007231 CoA binding site [chemical binding]; other site 446471007232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471007233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471007234 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 446471007235 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471007236 Walker A/P-loop; other site 446471007237 ATP binding site [chemical binding]; other site 446471007238 Q-loop/lid; other site 446471007239 ABC transporter signature motif; other site 446471007240 Walker B; other site 446471007241 D-loop; other site 446471007242 H-loop/switch region; other site 446471007243 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 446471007244 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446471007245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471007246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471007247 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 446471007248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446471007249 Histidine kinase; Region: HisKA_3; pfam07730 446471007250 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471007251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471007252 active site 446471007253 phosphorylation site [posttranslational modification] 446471007254 intermolecular recognition site; other site 446471007255 dimerization interface [polypeptide binding]; other site 446471007256 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471007257 DNA binding residues [nucleotide binding] 446471007258 dimerization interface [polypeptide binding]; other site 446471007259 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 446471007260 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471007261 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471007262 Walker A/P-loop; other site 446471007263 ATP binding site [chemical binding]; other site 446471007264 Q-loop/lid; other site 446471007265 ABC transporter signature motif; other site 446471007266 Walker B; other site 446471007267 D-loop; other site 446471007268 H-loop/switch region; other site 446471007269 FtsX-like permease family; Region: FtsX; pfam02687 446471007270 FtsX-like permease family; Region: FtsX; pfam02687 446471007271 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446471007272 active site 446471007273 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446471007274 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471007275 Walker A/P-loop; other site 446471007276 ATP binding site [chemical binding]; other site 446471007277 Q-loop/lid; other site 446471007278 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 446471007279 ABC transporter signature motif; other site 446471007280 Walker B; other site 446471007281 D-loop; other site 446471007282 ABC transporter; Region: ABC_tran_2; pfam12848 446471007283 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 446471007284 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 446471007285 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 446471007286 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 446471007287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471007288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 446471007289 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446471007290 G5 domain; Region: G5; pfam07501 446471007291 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 446471007292 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446471007293 catalytic residue [active] 446471007294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 446471007295 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446471007296 G5 domain; Region: G5; pfam07501 446471007297 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 446471007298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 446471007299 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446471007300 G5 domain; Region: G5; pfam07501 446471007301 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 446471007302 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446471007303 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446471007304 G5 domain; Region: G5; pfam07501 446471007305 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 446471007306 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446471007307 catalytic residue [active] 446471007308 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 446471007309 active site 446471007310 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 446471007311 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 446471007312 active site 446471007313 HIGH motif; other site 446471007314 KMSKS motif; other site 446471007315 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 446471007316 tRNA binding surface [nucleotide binding]; other site 446471007317 anticodon binding site; other site 446471007318 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 446471007319 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 446471007320 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446471007321 Isochorismatase family; Region: Isochorismatase; pfam00857 446471007322 catalytic triad [active] 446471007323 conserved cis-peptide bond; other site 446471007324 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 446471007325 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 446471007326 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 446471007327 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 446471007328 active site 446471007329 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 446471007330 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 446471007331 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446471007332 active site 446471007333 LysE type translocator; Region: LysE; cl00565 446471007334 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446471007335 DNA binding residues [nucleotide binding] 446471007336 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446471007337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471007338 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446471007339 anti sigma factor interaction site; other site 446471007340 regulatory phosphorylation site [posttranslational modification]; other site 446471007341 GAF domain; Region: GAF; cl00853 446471007342 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 446471007343 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446471007344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007345 dimer interface [polypeptide binding]; other site 446471007346 conserved gate region; other site 446471007347 putative PBP binding loops; other site 446471007348 ABC-ATPase subunit interface; other site 446471007349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007350 dimer interface [polypeptide binding]; other site 446471007351 conserved gate region; other site 446471007352 putative PBP binding loops; other site 446471007353 ABC-ATPase subunit interface; other site 446471007354 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446471007355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471007356 Walker A/P-loop; other site 446471007357 ATP binding site [chemical binding]; other site 446471007358 Q-loop/lid; other site 446471007359 ABC transporter signature motif; other site 446471007360 Walker B; other site 446471007361 D-loop; other site 446471007362 H-loop/switch region; other site 446471007363 TOBE domain; Region: TOBE_2; cl01440 446471007364 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 446471007365 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471007366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471007367 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471007368 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471007369 DNA binding site [nucleotide binding] 446471007370 domain linker motif; other site 446471007371 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446471007372 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471007373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471007374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007375 dimer interface [polypeptide binding]; other site 446471007376 conserved gate region; other site 446471007377 putative PBP binding loops; other site 446471007378 ABC-ATPase subunit interface; other site 446471007379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007380 dimer interface [polypeptide binding]; other site 446471007381 conserved gate region; other site 446471007382 putative PBP binding loops; other site 446471007383 ABC-ATPase subunit interface; other site 446471007384 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471007385 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 446471007386 heme binding pocket [chemical binding]; other site 446471007387 heme ligand [chemical binding]; other site 446471007388 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 446471007389 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446471007390 intersubunit interface [polypeptide binding]; other site 446471007391 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446471007392 ABC-ATPase subunit interface; other site 446471007393 dimer interface [polypeptide binding]; other site 446471007394 putative PBP binding regions; other site 446471007395 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 446471007396 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446471007397 Walker A/P-loop; other site 446471007398 ATP binding site [chemical binding]; other site 446471007399 Q-loop/lid; other site 446471007400 ABC transporter signature motif; other site 446471007401 Walker B; other site 446471007402 D-loop; other site 446471007403 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 446471007404 Survival protein SurE; Region: SurE; cl00448 446471007405 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446471007406 substrate binding site [chemical binding]; other site 446471007407 ATP binding site [chemical binding]; other site 446471007408 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446471007409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471007410 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 446471007411 iron-sulfur cluster [ion binding]; other site 446471007412 [2Fe-2S] cluster binding site [ion binding]; other site 446471007413 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446471007414 active site 446471007415 metal binding site [ion binding]; metal-binding site 446471007416 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446471007417 Predicted membrane protein [Function unknown]; Region: COG1470 446471007418 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446471007419 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471007420 patatin-related protein; Region: TIGR03607 446471007421 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 446471007422 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446471007423 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446471007424 DNA binding residues [nucleotide binding] 446471007425 dimer interface [polypeptide binding]; other site 446471007426 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 446471007427 Protein of unknown function (DUF419); Region: DUF419; cl15265 446471007428 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 446471007429 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 446471007430 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 446471007431 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 446471007432 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446471007433 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 446471007434 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471007435 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471007436 DNA binding site [nucleotide binding] 446471007437 domain linker motif; other site 446471007438 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446471007439 dimerization interface [polypeptide binding]; other site 446471007440 ligand binding site [chemical binding]; other site 446471007441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471007442 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446471007443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007444 putative PBP binding loops; other site 446471007445 dimer interface [polypeptide binding]; other site 446471007446 ABC-ATPase subunit interface; other site 446471007447 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471007448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007449 dimer interface [polypeptide binding]; other site 446471007450 conserved gate region; other site 446471007451 ABC-ATPase subunit interface; other site 446471007452 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471007453 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446471007454 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 446471007455 Fatty acid desaturase; Region: FA_desaturase; pfam00487 446471007456 putative di-iron ligands [ion binding]; other site 446471007457 Domain of unknown function DUF21; Region: DUF21; pfam01595 446471007458 FOG: CBS domain [General function prediction only]; Region: COG0517 446471007459 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446471007460 Transporter associated domain; Region: CorC_HlyC; cl08393 446471007461 Domain of unknown function DUF21; Region: DUF21; pfam01595 446471007462 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446471007463 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471007464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007465 dimer interface [polypeptide binding]; other site 446471007466 conserved gate region; other site 446471007467 putative PBP binding loops; other site 446471007468 ABC-ATPase subunit interface; other site 446471007469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007470 dimer interface [polypeptide binding]; other site 446471007471 conserved gate region; other site 446471007472 putative PBP binding loops; other site 446471007473 ABC-ATPase subunit interface; other site 446471007474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471007475 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471007476 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471007477 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471007478 DNA binding site [nucleotide binding] 446471007479 domain linker motif; other site 446471007480 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446471007481 ligand binding site [chemical binding]; other site 446471007482 dimerization interface [polypeptide binding]; other site 446471007483 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471007484 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 446471007485 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471007486 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471007487 Walker A/P-loop; other site 446471007488 ATP binding site [chemical binding]; other site 446471007489 Q-loop/lid; other site 446471007490 ABC transporter signature motif; other site 446471007491 Walker B; other site 446471007492 D-loop; other site 446471007493 H-loop/switch region; other site 446471007494 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471007495 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471007496 Walker A/P-loop; other site 446471007497 ATP binding site [chemical binding]; other site 446471007498 Q-loop/lid; other site 446471007499 ABC transporter signature motif; other site 446471007500 Walker B; other site 446471007501 D-loop; other site 446471007502 H-loop/switch region; other site 446471007503 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471007504 DNA binding residues [nucleotide binding] 446471007505 TOBE domain; Region: TOBE_2; cl01440 446471007506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471007507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007508 dimer interface [polypeptide binding]; other site 446471007509 conserved gate region; other site 446471007510 putative PBP binding loops; other site 446471007511 ABC-ATPase subunit interface; other site 446471007512 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 446471007513 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471007514 Walker A/P-loop; other site 446471007515 ATP binding site [chemical binding]; other site 446471007516 Q-loop/lid; other site 446471007517 ABC transporter signature motif; other site 446471007518 Walker B; other site 446471007519 D-loop; other site 446471007520 H-loop/switch region; other site 446471007521 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446471007522 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 446471007523 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 446471007524 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 446471007525 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 446471007526 active site 446471007527 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 446471007528 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 446471007529 SAF domain; Region: SAF; cl00555 446471007530 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 446471007531 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 446471007532 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 446471007533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471007534 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 446471007535 Phosphotransferase enzyme family; Region: APH; pfam01636 446471007536 putative active site [active] 446471007537 putative substrate binding site [chemical binding]; other site 446471007538 ATP binding site [chemical binding]; other site 446471007539 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471007540 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471007541 Walker A/P-loop; other site 446471007542 ATP binding site [chemical binding]; other site 446471007543 Q-loop/lid; other site 446471007544 ABC transporter signature motif; other site 446471007545 Walker B; other site 446471007546 D-loop; other site 446471007547 H-loop/switch region; other site 446471007548 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 446471007549 active site 446471007550 nucleophile elbow; other site 446471007551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471007552 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446471007553 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 446471007554 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 446471007555 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446471007556 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 446471007557 N- and C-terminal domain interface [polypeptide binding]; other site 446471007558 D-xylulose kinase; Region: XylB; TIGR01312 446471007559 active site 446471007560 MgATP binding site [chemical binding]; other site 446471007561 catalytic site [active] 446471007562 metal binding site [ion binding]; metal-binding site 446471007563 carbohydrate binding site [chemical binding]; other site 446471007564 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471007565 DNA binding residues [nucleotide binding] 446471007566 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 446471007567 active site 446471007568 catalytic site [active] 446471007569 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446471007570 Catalytic site [active] 446471007571 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 446471007572 folate binding site [chemical binding]; other site 446471007573 NADP+ binding site [chemical binding]; other site 446471007574 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 446471007575 dimerization interface [polypeptide binding]; other site 446471007576 active site 446471007577 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 446471007578 Catalytic site [active] 446471007579 OsmC-like protein; Region: OsmC; cl00767 446471007580 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 446471007581 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446471007582 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446471007583 catalytic residue [active] 446471007584 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446471007585 Ligand Binding Site [chemical binding]; other site 446471007586 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446471007587 NlpC/P60 family; Region: NLPC_P60; cl11438 446471007588 NlpC/P60 family; Region: NLPC_P60; cl11438 446471007589 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 446471007590 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471007591 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 446471007592 FeoA domain; Region: FeoA; cl00838 446471007593 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446471007594 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446471007595 catalytic residue [active] 446471007596 H+ Antiporter protein; Region: 2A0121; TIGR00900 446471007597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471007598 putative substrate translocation pore; other site 446471007599 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 446471007600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471007601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471007602 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 446471007603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471007604 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446471007605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471007606 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 446471007607 Chain length determinant protein; Region: Wzz; cl01623 446471007608 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 446471007609 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 446471007610 Divergent AAA domain; Region: AAA_4; pfam04326 446471007611 Cache domain; Region: Cache_1; pfam02743 446471007612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446471007613 dimerization interface [polypeptide binding]; other site 446471007614 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 446471007615 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 446471007616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446471007617 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446471007618 anti sigma factor interaction site; other site 446471007619 regulatory phosphorylation site [posttranslational modification]; other site 446471007620 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 446471007621 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234 446471007622 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 446471007623 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446471007624 anti sigma factor interaction site; other site 446471007625 regulatory phosphorylation site [posttranslational modification]; other site 446471007626 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 446471007627 dimerization interface [polypeptide binding]; other site 446471007628 putative active cleft [active] 446471007629 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446471007630 conserved cys residue [active] 446471007631 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 446471007632 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 446471007633 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 446471007634 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 446471007635 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 446471007636 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 446471007637 EthD protein; Region: EthD; cl06234 446471007638 EthD protein; Region: EthD; cl06234 446471007639 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 446471007640 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446471007641 PYR/PP interface [polypeptide binding]; other site 446471007642 dimer interface [polypeptide binding]; other site 446471007643 TPP binding site [chemical binding]; other site 446471007644 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 446471007645 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 446471007646 TPP-binding site [chemical binding]; other site 446471007647 dimer interface [polypeptide binding]; other site 446471007648 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 446471007649 potential catalytic triad [active] 446471007650 conserved cys residue [active] 446471007651 Predicted ATPase [General function prediction only]; Region: COG4637 446471007652 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471007653 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471007654 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471007655 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 446471007656 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 446471007657 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 446471007658 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 446471007659 Predicted transcriptional regulator [Transcription]; Region: COG5340 446471007660 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 446471007661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471007662 non-specific DNA binding site [nucleotide binding]; other site 446471007663 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 446471007664 salt bridge; other site 446471007665 sequence-specific DNA binding site [nucleotide binding]; other site 446471007666 Archaeal ATPase; Region: Arch_ATPase; pfam01637 446471007667 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 446471007668 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 446471007669 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 446471007670 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471007671 non-specific DNA binding site [nucleotide binding]; other site 446471007672 salt bridge; other site 446471007673 sequence-specific DNA binding site [nucleotide binding]; other site 446471007674 Chain length determinant protein; Region: Wzz; cl01623 446471007675 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 446471007676 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471007677 Divergent AAA domain; Region: AAA_4; pfam04326 446471007678 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 446471007679 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 446471007680 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446471007681 DNA binding residues [nucleotide binding] 446471007682 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 446471007683 FMN binding site [chemical binding]; other site 446471007684 dimer interface [polypeptide binding]; other site 446471007685 F420H2 dehydrogenase subunit F; Provisional; Region: PRK09326 446471007686 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 446471007687 MatE; Region: MatE; cl10513 446471007688 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 446471007689 putative transposase OrfB; Reviewed; Region: PHA02517 446471007690 Integrase core domain; Region: rve; cl01316 446471007691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471007692 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446471007693 active site 446471007694 putative glycosyl transferase; Provisional; Region: PRK10073 446471007695 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471007696 active site 446471007697 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446471007698 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 446471007699 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446471007700 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 446471007701 Bacterial sugar transferase; Region: Bac_transf; cl00939 446471007702 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446471007703 active site 446471007704 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 446471007705 MatE; Region: MatE; cl10513 446471007706 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446471007707 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446471007708 DNA binding site [nucleotide binding] 446471007709 domain linker motif; other site 446471007710 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446471007711 ligand binding site [chemical binding]; other site 446471007712 dimerization interface (open form) [polypeptide binding]; other site 446471007713 dimerization interface (closed form) [polypeptide binding]; other site 446471007714 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471007715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007716 dimer interface [polypeptide binding]; other site 446471007717 conserved gate region; other site 446471007718 putative PBP binding loops; other site 446471007719 ABC-ATPase subunit interface; other site 446471007720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007721 dimer interface [polypeptide binding]; other site 446471007722 conserved gate region; other site 446471007723 putative PBP binding loops; other site 446471007724 ABC-ATPase subunit interface; other site 446471007725 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471007726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471007727 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 446471007728 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 446471007729 Phd_YefM; Region: PhdYeFM; cl09153 446471007730 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 446471007731 oligomeric interface; other site 446471007732 putative active site [active] 446471007733 homodimer interface [polypeptide binding]; other site 446471007734 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446471007735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471007736 non-specific DNA binding site [nucleotide binding]; other site 446471007737 salt bridge; other site 446471007738 sequence-specific DNA binding site [nucleotide binding]; other site 446471007739 Permease family; Region: Xan_ur_permease; cl00967 446471007740 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 446471007741 Bacterial sugar transferase; Region: Bac_transf; cl00939 446471007742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471007743 ATP binding site [chemical binding]; other site 446471007744 Mg2+ binding site [ion binding]; other site 446471007745 G-X-G motif; other site 446471007746 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 446471007747 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 446471007748 DNA-binding site [nucleotide binding]; DNA binding site 446471007749 RNA-binding motif; other site 446471007750 Antirestriction protein; Region: Antirestrict; pfam03230 446471007751 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446471007752 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471007753 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471007754 nucleotide binding region [chemical binding]; other site 446471007755 ATP-binding site [chemical binding]; other site 446471007756 Domain of unknown function (DUF477); Region: DUF477; cl01535 446471007757 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 446471007758 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 446471007759 catalytic triad [active] 446471007760 LabA_like proteins; Region: LabA_like; cd06167 446471007761 putative metal binding site [ion binding]; other site 446471007762 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446471007763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471007764 active site 446471007765 phosphorylation site [posttranslational modification] 446471007766 intermolecular recognition site; other site 446471007767 dimerization interface [polypeptide binding]; other site 446471007768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446471007769 DNA binding site [nucleotide binding] 446471007770 sensor protein BasS/PmrB; Provisional; Region: PRK10755 446471007771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446471007772 dimer interface [polypeptide binding]; other site 446471007773 phosphorylation site [posttranslational modification] 446471007774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471007775 ATP binding site [chemical binding]; other site 446471007776 Mg2+ binding site [ion binding]; other site 446471007777 G-X-G motif; other site 446471007778 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 446471007779 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 446471007780 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 446471007781 ring oligomerisation interface [polypeptide binding]; other site 446471007782 ATP/Mg binding site [chemical binding]; other site 446471007783 stacking interactions; other site 446471007784 hinge regions; other site 446471007785 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 446471007786 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 446471007787 ligand binding site [chemical binding]; other site 446471007788 active site 446471007789 UGI interface [polypeptide binding]; other site 446471007790 catalytic site [active] 446471007791 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 446471007792 active site 446471007793 catalytic triad [active] 446471007794 oxyanion hole [active] 446471007795 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446471007796 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 446471007797 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446471007798 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446471007799 active site 446471007800 ATP binding site [chemical binding]; other site 446471007801 substrate binding site [chemical binding]; other site 446471007802 activation loop (A-loop); other site 446471007803 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 446471007804 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 446471007805 active site 446471007806 homotetramer interface [polypeptide binding]; other site 446471007807 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 446471007808 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446471007809 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 446471007810 Walker A/P-loop; other site 446471007811 ATP binding site [chemical binding]; other site 446471007812 Q-loop/lid; other site 446471007813 ABC transporter signature motif; other site 446471007814 Walker B; other site 446471007815 D-loop; other site 446471007816 H-loop/switch region; other site 446471007817 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 446471007818 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 446471007819 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 446471007820 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 446471007821 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446471007822 active site 446471007823 HIGH motif; other site 446471007824 nucleotide binding site [chemical binding]; other site 446471007825 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 446471007826 KMSKS motif; other site 446471007827 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446471007828 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 446471007829 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446471007830 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446471007831 catalytic residue [active] 446471007832 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 446471007833 FAD binding domain; Region: FAD_binding_4; pfam01565 446471007834 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 446471007835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471007836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471007837 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 446471007838 homotrimer interaction site [polypeptide binding]; other site 446471007839 zinc binding site [ion binding]; other site 446471007840 CDP-binding sites; other site 446471007841 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471007842 active site 446471007843 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 446471007844 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 446471007845 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 446471007846 Walker A/P-loop; other site 446471007847 ATP binding site [chemical binding]; other site 446471007848 Q-loop/lid; other site 446471007849 ABC transporter signature motif; other site 446471007850 Walker B; other site 446471007851 D-loop; other site 446471007852 H-loop/switch region; other site 446471007853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007854 dimer interface [polypeptide binding]; other site 446471007855 conserved gate region; other site 446471007856 putative PBP binding loops; other site 446471007857 ABC-ATPase subunit interface; other site 446471007858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007859 dimer interface [polypeptide binding]; other site 446471007860 conserved gate region; other site 446471007861 putative PBP binding loops; other site 446471007862 ABC-ATPase subunit interface; other site 446471007863 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471007864 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 446471007865 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 446471007866 Walker A/P-loop; other site 446471007867 ATP binding site [chemical binding]; other site 446471007868 Q-loop/lid; other site 446471007869 ABC transporter signature motif; other site 446471007870 Walker B; other site 446471007871 D-loop; other site 446471007872 H-loop/switch region; other site 446471007873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007874 dimer interface [polypeptide binding]; other site 446471007875 conserved gate region; other site 446471007876 putative PBP binding loops; other site 446471007877 ABC-ATPase subunit interface; other site 446471007878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007879 dimer interface [polypeptide binding]; other site 446471007880 conserved gate region; other site 446471007881 putative PBP binding loops; other site 446471007882 ABC-ATPase subunit interface; other site 446471007883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471007884 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446471007885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471007886 active site 446471007887 phosphorylation site [posttranslational modification] 446471007888 intermolecular recognition site; other site 446471007889 dimerization interface [polypeptide binding]; other site 446471007890 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446471007891 DNA binding site [nucleotide binding] 446471007892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446471007893 dimer interface [polypeptide binding]; other site 446471007894 phosphorylation site [posttranslational modification] 446471007895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471007896 ATP binding site [chemical binding]; other site 446471007897 Mg2+ binding site [ion binding]; other site 446471007898 G-X-G motif; other site 446471007899 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 446471007900 PhoU domain; Region: PhoU; pfam01895 446471007901 PhoU domain; Region: PhoU; pfam01895 446471007902 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446471007903 catalytic core [active] 446471007904 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 446471007905 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 446471007906 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 446471007907 putative ADP-binding pocket [chemical binding]; other site 446471007908 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 446471007909 Lsr2; Region: Lsr2; pfam11774 446471007910 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 446471007911 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 446471007912 dimer interface [polypeptide binding]; other site 446471007913 putative anticodon binding site; other site 446471007914 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 446471007915 motif 1; other site 446471007916 dimer interface [polypeptide binding]; other site 446471007917 active site 446471007918 motif 2; other site 446471007919 motif 3; other site 446471007920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471007921 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 446471007922 Bacterial membrane flanked domain; Region: DUF304; cl01348 446471007923 Bacterial membrane flanked domain; Region: DUF304; cl01348 446471007924 Bacterial membrane flanked domain; Region: DUF304; cl01348 446471007925 Bacterial membrane flanked domain; Region: DUF304; cl01348 446471007926 Bacterial membrane flanked domain; Region: DUF304; cl01348 446471007927 Predicted membrane protein [Function unknown]; Region: COG3428 446471007928 Bacterial membrane flanked domain; Region: DUF304; cl01348 446471007929 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 446471007930 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 446471007931 homooctamer interface [polypeptide binding]; other site 446471007932 active site 446471007933 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 446471007934 catalytic center binding site [active] 446471007935 ATP binding site [chemical binding]; other site 446471007936 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 446471007937 Pterin binding enzyme; Region: Pterin_bind; pfam00809 446471007938 substrate binding pocket [chemical binding]; other site 446471007939 inhibitor binding site; inhibition site 446471007940 GTP cyclohydrolase I; Provisional; Region: PLN03044 446471007941 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 446471007942 homodecamer interface [polypeptide binding]; other site 446471007943 active site 446471007944 putative catalytic site residues [active] 446471007945 zinc binding site [ion binding]; other site 446471007946 GTP-CH-I/GFRP interaction surface; other site 446471007947 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 446471007948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471007949 Walker A motif; other site 446471007950 ATP binding site [chemical binding]; other site 446471007951 Walker B motif; other site 446471007952 arginine finger; other site 446471007953 Peptidase family M41; Region: Peptidase_M41; pfam01434 446471007954 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446471007955 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 446471007956 Ligand Binding Site [chemical binding]; other site 446471007957 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 446471007958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446471007959 dimer interface [polypeptide binding]; other site 446471007960 phosphorylation site [posttranslational modification] 446471007961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446471007962 ATP binding site [chemical binding]; other site 446471007963 Mg2+ binding site [ion binding]; other site 446471007964 G-X-G motif; other site 446471007965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446471007966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471007967 active site 446471007968 phosphorylation site [posttranslational modification] 446471007969 intermolecular recognition site; other site 446471007970 dimerization interface [polypeptide binding]; other site 446471007971 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471007972 DNA binding site [nucleotide binding] 446471007973 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446471007974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471007975 dimer interface [polypeptide binding]; other site 446471007976 conserved gate region; other site 446471007977 putative PBP binding loops; other site 446471007978 ABC-ATPase subunit interface; other site 446471007979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446471007980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446471007981 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 446471007982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471007983 Walker A/P-loop; other site 446471007984 ATP binding site [chemical binding]; other site 446471007985 Q-loop/lid; other site 446471007986 ABC transporter signature motif; other site 446471007987 Walker B; other site 446471007988 D-loop; other site 446471007989 H-loop/switch region; other site 446471007990 TOBE domain; Region: TOBE_2; cl01440 446471007991 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 446471007992 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 446471007993 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 446471007994 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 446471007995 dimer interface [polypeptide binding]; other site 446471007996 substrate binding site [chemical binding]; other site 446471007997 metal binding sites [ion binding]; metal-binding site 446471007998 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 446471007999 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446471008000 catalytic Zn binding site [ion binding]; other site 446471008001 NAD(P) binding site [chemical binding]; other site 446471008002 structural Zn binding site [ion binding]; other site 446471008003 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 446471008004 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446471008005 NlpC/P60 family; Region: NLPC_P60; cl11438 446471008006 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 446471008007 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446471008008 homodimer interface [polypeptide binding]; other site 446471008009 substrate-cofactor binding pocket; other site 446471008010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471008011 catalytic residue [active] 446471008012 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 446471008013 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 446471008014 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446471008015 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446471008016 dimer interface [polypeptide binding]; other site 446471008017 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 446471008018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446471008019 DNA-binding site [nucleotide binding]; DNA binding site 446471008020 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446471008021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471008022 homodimer interface [polypeptide binding]; other site 446471008023 catalytic residue [active] 446471008024 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446471008025 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 446471008026 NAD(P) binding site [chemical binding]; other site 446471008027 Domain of unknown function DUF77; Region: DUF77; cl00307 446471008028 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 446471008029 dimer interface [polypeptide binding]; other site 446471008030 phosphate binding site [ion binding]; other site 446471008031 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471008032 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446471008033 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446471008034 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 446471008035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446471008036 DNA-binding site [nucleotide binding]; DNA binding site 446471008037 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446471008038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471008039 homodimer interface [polypeptide binding]; other site 446471008040 catalytic residue [active] 446471008041 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446471008042 active site 446471008043 catalytic tetrad [active] 446471008044 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 446471008045 putative FMN binding site [chemical binding]; other site 446471008046 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446471008047 FAD binding domain; Region: FAD_binding_4; pfam01565 446471008048 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 446471008049 OsmC-like protein; Region: OsmC; cl00767 446471008050 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 446471008051 putative active site [active] 446471008052 dimerization interface [polypeptide binding]; other site 446471008053 putative tRNAtyr binding site [nucleotide binding]; other site 446471008054 L-asparaginase II; Region: Asparaginase_II; cl01842 446471008055 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 446471008056 putative active site [active] 446471008057 Phd_YefM; Region: PhdYeFM; cl09153 446471008058 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 446471008059 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 446471008060 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446471008061 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 446471008062 heme-binding site [chemical binding]; other site 446471008063 YceI-like domain; Region: YceI; cl01001 446471008064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446471008065 DNA binding site [nucleotide binding] 446471008066 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471008067 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446471008068 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 446471008069 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446471008070 minor groove reading motif; other site 446471008071 helix-hairpin-helix signature motif; other site 446471008072 substrate binding pocket [chemical binding]; other site 446471008073 active site 446471008074 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 446471008075 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446471008076 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446471008077 ligand binding site [chemical binding]; other site 446471008078 flexible hinge region; other site 446471008079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008080 putative switch regulator; other site 446471008081 non-specific DNA interactions [nucleotide binding]; other site 446471008082 DNA binding site [nucleotide binding] 446471008083 sequence specific DNA binding site [nucleotide binding]; other site 446471008084 putative cAMP binding site [chemical binding]; other site 446471008085 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 446471008086 homotrimer interaction site [polypeptide binding]; other site 446471008087 putative active site [active] 446471008088 Transglycosylase; Region: Transgly; cl07896 446471008089 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446471008090 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 446471008091 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 446471008092 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446471008093 putative active site [active] 446471008094 putative metal binding site [ion binding]; other site 446471008095 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 446471008096 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446471008097 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446471008098 ABC-ATPase subunit interface; other site 446471008099 dimer interface [polypeptide binding]; other site 446471008100 putative PBP binding regions; other site 446471008101 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446471008102 dimer interface [polypeptide binding]; other site 446471008103 putative PBP binding regions; other site 446471008104 ABC-ATPase subunit interface; other site 446471008105 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446471008106 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446471008107 siderophore binding site; other site 446471008108 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446471008109 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446471008110 Walker A/P-loop; other site 446471008111 ATP binding site [chemical binding]; other site 446471008112 Q-loop/lid; other site 446471008113 ABC transporter signature motif; other site 446471008114 Walker B; other site 446471008115 D-loop; other site 446471008116 H-loop/switch region; other site 446471008117 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471008118 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471008119 Walker A/P-loop; other site 446471008120 ATP binding site [chemical binding]; other site 446471008121 Q-loop/lid; other site 446471008122 ABC transporter signature motif; other site 446471008123 Walker B; other site 446471008124 D-loop; other site 446471008125 H-loop/switch region; other site 446471008126 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 446471008127 FtsX-like permease family; Region: FtsX; pfam02687 446471008128 FtsX-like permease family; Region: FtsX; pfam02687 446471008129 Divergent AAA domain; Region: AAA_4; pfam04326 446471008130 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 446471008131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446471008132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471008133 NeuB family; Region: NeuB; cl00496 446471008134 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 446471008135 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446471008136 nudix motif; other site 446471008137 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 446471008138 active site 446471008139 catalytic triad [active] 446471008140 oxyanion hole [active] 446471008141 tyramine oxidase; Provisional; Region: tynA; PRK11504 446471008142 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 446471008143 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 446471008144 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 446471008145 Amino acid permease; Region: AA_permease; cl00524 446471008146 Amino acid permease; Region: AA_permease; cl00524 446471008147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008149 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446471008150 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 446471008151 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 446471008152 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 446471008153 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446471008154 dimer interface [polypeptide binding]; other site 446471008155 active site 446471008156 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446471008157 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 446471008158 Walker A/P-loop; other site 446471008159 ATP binding site [chemical binding]; other site 446471008160 Q-loop/lid; other site 446471008161 ABC transporter signature motif; other site 446471008162 Walker B; other site 446471008163 D-loop; other site 446471008164 H-loop/switch region; other site 446471008165 Cobalt transport protein; Region: CbiQ; cl00463 446471008166 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 446471008167 CHY zinc finger; Region: zf-CHY; pfam05495 446471008168 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 446471008169 putative homodimer interface [polypeptide binding]; other site 446471008170 putative active site [active] 446471008171 catalytic site [active] 446471008172 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 446471008173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446471008174 ATP binding site [chemical binding]; other site 446471008175 putative Mg++ binding site [ion binding]; other site 446471008176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446471008177 nucleotide binding region [chemical binding]; other site 446471008178 ATP-binding site [chemical binding]; other site 446471008179 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 446471008180 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 446471008181 active site 446471008182 8-oxo-dGMP binding site [chemical binding]; other site 446471008183 nudix motif; other site 446471008184 metal binding site [ion binding]; metal-binding site 446471008185 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446471008186 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 446471008187 active site 446471008188 catalytic site [active] 446471008189 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 446471008190 UDP-glucose 4-epimerase; Region: PLN02240 446471008191 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 446471008192 NAD binding site [chemical binding]; other site 446471008193 homodimer interface [polypeptide binding]; other site 446471008194 active site 446471008195 substrate binding site [chemical binding]; other site 446471008196 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 446471008197 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 446471008198 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 446471008199 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446471008200 DNA binding residues [nucleotide binding] 446471008201 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 446471008202 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 446471008203 dimerization interface [polypeptide binding]; other site 446471008204 putative ATP binding site [chemical binding]; other site 446471008205 amidophosphoribosyltransferase; Provisional; Region: PRK07847 446471008206 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 446471008207 active site 446471008208 tetramer interface [polypeptide binding]; other site 446471008209 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446471008210 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 446471008211 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446471008212 putative catalytic site [active] 446471008213 putative metal binding site [ion binding]; other site 446471008214 putative phosphate binding site [ion binding]; other site 446471008215 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 446471008216 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 446471008217 putative active site [active] 446471008218 putative metal binding site [ion binding]; other site 446471008219 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 446471008220 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 446471008221 chitin/cellulose binding site [chemical binding]; other site 446471008222 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 446471008223 chitin/cellulose binding site [chemical binding]; other site 446471008224 RNB domain; Region: RNB; pfam00773 446471008225 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 446471008226 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 446471008227 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 446471008228 trimer interface [polypeptide binding]; other site 446471008229 putative metal binding site [ion binding]; other site 446471008230 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446471008231 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 446471008232 dimer interface [polypeptide binding]; other site 446471008233 FMN binding site [chemical binding]; other site 446471008234 NADPH bind site [chemical binding]; other site 446471008235 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 446471008236 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 446471008237 Core-2/I-Branching enzyme; Region: Branch; pfam02485 446471008238 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471008239 active site 446471008240 colanic acid exporter; Provisional; Region: PRK10459 446471008241 MatE; Region: MatE; cl10513 446471008242 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 446471008243 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471008244 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 446471008245 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 446471008246 dimerization interface [polypeptide binding]; other site 446471008247 ATP binding site [chemical binding]; other site 446471008248 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 446471008249 dimerization interface [polypeptide binding]; other site 446471008250 ATP binding site [chemical binding]; other site 446471008251 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 446471008252 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446471008253 active site 446471008254 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446471008255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008256 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 446471008257 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446471008258 dimer interface [polypeptide binding]; other site 446471008259 active site 446471008260 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 446471008261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471008262 NAD(P) binding site [chemical binding]; other site 446471008263 active site 446471008264 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446471008265 active site 2 [active] 446471008266 active site 1 [active] 446471008267 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 446471008268 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446471008269 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 446471008270 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446471008271 Aminotransferase class-V; Region: Aminotran_5; pfam00266 446471008272 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446471008273 catalytic residue [active] 446471008274 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 446471008275 active site residue [active] 446471008276 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 446471008277 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446471008278 homodimer interface [polypeptide binding]; other site 446471008279 substrate-cofactor binding pocket; other site 446471008280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471008281 catalytic residue [active] 446471008282 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 446471008283 Plant ATP synthase F0; Region: YMF19; cl07975 446471008284 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 446471008285 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446471008286 FeS/SAM binding site; other site 446471008287 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 446471008288 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 446471008289 putative active site [active] 446471008290 catalytic triad [active] 446471008291 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 446471008292 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446471008293 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471008294 Walker A/P-loop; other site 446471008295 ATP binding site [chemical binding]; other site 446471008296 Q-loop/lid; other site 446471008297 ABC transporter signature motif; other site 446471008298 Walker B; other site 446471008299 D-loop; other site 446471008300 H-loop/switch region; other site 446471008301 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446471008302 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 446471008303 ATP binding site [chemical binding]; other site 446471008304 active site 446471008305 substrate binding site [chemical binding]; other site 446471008306 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 446471008307 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 446471008308 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446471008309 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 446471008310 Predicted transcriptional regulator [Transcription]; Region: COG2378 446471008311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008312 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471008313 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446471008314 Walker A/P-loop; other site 446471008315 ATP binding site [chemical binding]; other site 446471008316 Q-loop/lid; other site 446471008317 ABC transporter signature motif; other site 446471008318 Walker B; other site 446471008319 D-loop; other site 446471008320 H-loop/switch region; other site 446471008321 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446471008322 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 446471008323 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 446471008324 GDP-binding site [chemical binding]; other site 446471008325 ACT binding site; other site 446471008326 IMP binding site; other site 446471008327 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446471008328 anti sigma factor interaction site; other site 446471008329 regulatory phosphorylation site [posttranslational modification]; other site 446471008330 bacterio-opsin activator; Provisional; Region: PRK13558 446471008331 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 446471008332 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 446471008333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446471008334 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446471008335 anti sigma factor interaction site; other site 446471008336 regulatory phosphorylation site [posttranslational modification]; other site 446471008337 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 446471008338 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 446471008339 active site 446471008340 intersubunit interface [polypeptide binding]; other site 446471008341 zinc binding site [ion binding]; other site 446471008342 Na+ binding site [ion binding]; other site 446471008343 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 446471008344 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 446471008345 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446471008346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446471008347 UMP phosphatase; Provisional; Region: PRK10444 446471008348 active site 446471008349 motif I; other site 446471008350 motif II; other site 446471008351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446471008352 Cellulose binding domain; Region: CBM_2; cl02709 446471008353 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446471008354 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 446471008355 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 446471008356 classical (c) SDRs; Region: SDR_c; cd05233 446471008357 NAD(P) binding site [chemical binding]; other site 446471008358 active site 446471008359 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446471008360 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471008361 Walker A/P-loop; other site 446471008362 ATP binding site [chemical binding]; other site 446471008363 Q-loop/lid; other site 446471008364 ABC transporter signature motif; other site 446471008365 Walker B; other site 446471008366 D-loop; other site 446471008367 H-loop/switch region; other site 446471008368 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471008369 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471008370 Walker A/P-loop; other site 446471008371 ATP binding site [chemical binding]; other site 446471008372 Q-loop/lid; other site 446471008373 ABC transporter signature motif; other site 446471008374 Walker B; other site 446471008375 D-loop; other site 446471008376 H-loop/switch region; other site 446471008377 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471008378 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446471008379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471008380 putative PBP binding loops; other site 446471008381 ABC-ATPase subunit interface; other site 446471008382 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446471008383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446471008384 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 446471008385 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446471008386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008387 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 446471008388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471008389 NAD(P) binding site [chemical binding]; other site 446471008390 active site 446471008391 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446471008392 putative metal binding site [ion binding]; other site 446471008393 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446471008394 putative catalytic site [active] 446471008395 putative phosphate binding site [ion binding]; other site 446471008396 putative metal binding site [ion binding]; other site 446471008397 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446471008398 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446471008399 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471008400 Walker A/P-loop; other site 446471008401 ATP binding site [chemical binding]; other site 446471008402 Q-loop/lid; other site 446471008403 ABC transporter signature motif; other site 446471008404 Walker B; other site 446471008405 D-loop; other site 446471008406 H-loop/switch region; other site 446471008407 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446471008408 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471008409 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 446471008410 Clp amino terminal domain; Region: Clp_N; pfam02861 446471008411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471008412 Walker A motif; other site 446471008413 ATP binding site [chemical binding]; other site 446471008414 Walker B motif; other site 446471008415 arginine finger; other site 446471008416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471008417 Walker A motif; other site 446471008418 ATP binding site [chemical binding]; other site 446471008419 Walker B motif; other site 446471008420 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 446471008421 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 446471008422 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 446471008423 putative active site [active] 446471008424 homotetrameric interface [polypeptide binding]; other site 446471008425 metal binding site [ion binding]; metal-binding site 446471008426 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446471008427 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 446471008428 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 446471008429 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446471008430 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471008431 Walker A/P-loop; other site 446471008432 ATP binding site [chemical binding]; other site 446471008433 Q-loop/lid; other site 446471008434 ABC transporter signature motif; other site 446471008435 Walker B; other site 446471008436 D-loop; other site 446471008437 H-loop/switch region; other site 446471008438 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471008439 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471008440 ATP binding site [chemical binding]; other site 446471008441 Q-loop/lid; other site 446471008442 ABC transporter signature motif; other site 446471008443 Walker B; other site 446471008444 D-loop; other site 446471008445 H-loop/switch region; other site 446471008446 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471008447 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 446471008448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471008449 dimer interface [polypeptide binding]; other site 446471008450 conserved gate region; other site 446471008451 putative PBP binding loops; other site 446471008452 ABC-ATPase subunit interface; other site 446471008453 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446471008454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446471008455 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446471008456 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446471008457 Predicted transcriptional regulator [Transcription]; Region: COG5340 446471008458 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 446471008459 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 446471008460 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 446471008461 Walker A/P-loop; other site 446471008462 ATP binding site [chemical binding]; other site 446471008463 Q-loop/lid; other site 446471008464 ABC transporter signature motif; other site 446471008465 Walker B; other site 446471008466 D-loop; other site 446471008467 H-loop/switch region; other site 446471008468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446471008469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446471008470 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471008471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471008472 active site 446471008473 phosphorylation site [posttranslational modification] 446471008474 intermolecular recognition site; other site 446471008475 dimerization interface [polypeptide binding]; other site 446471008476 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471008477 DNA binding residues [nucleotide binding] 446471008478 dimerization interface [polypeptide binding]; other site 446471008479 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 446471008480 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 446471008481 AlkA N-terminal domain; Region: AlkA_N; cl05528 446471008482 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446471008483 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446471008484 DNA binding site [nucleotide binding] 446471008485 active site 446471008486 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 446471008487 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 446471008488 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 446471008489 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 446471008490 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 446471008491 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 446471008492 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 446471008493 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 446471008494 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 446471008495 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 446471008496 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446471008497 trimer interface [polypeptide binding]; other site 446471008498 active site 446471008499 Pirin-related protein [General function prediction only]; Region: COG1741 446471008500 Cupin domain; Region: Cupin_2; cl09118 446471008501 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 446471008502 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446471008503 active site 446471008504 DinB superfamily; Region: DinB_2; cl00986 446471008505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446471008506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008507 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446471008508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446471008509 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471008510 DNA binding residues [nucleotide binding] 446471008511 dimerization interface [polypeptide binding]; other site 446471008512 Helix-turn-helix domain; Region: HTH_18; pfam12833 446471008513 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446471008514 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 446471008515 dimerization domain swap beta strand [polypeptide binding]; other site 446471008516 regulatory protein interface [polypeptide binding]; other site 446471008517 active site 446471008518 regulatory phosphorylation site [posttranslational modification]; other site 446471008519 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 446471008520 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 446471008521 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 446471008522 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 446471008523 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 446471008524 HPr interaction site; other site 446471008525 glycerol kinase (GK) interaction site [polypeptide binding]; other site 446471008526 active site 446471008527 phosphorylation site [posttranslational modification] 446471008528 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446471008529 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 446471008530 Domain of unknown function (DUF299); Region: DUF299; cl00780 446471008531 pyruvate phosphate dikinase; Provisional; Region: PRK09279 446471008532 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 446471008533 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 446471008534 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 446471008535 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446471008536 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 446471008537 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 446471008538 putative metal binding residues [ion binding]; other site 446471008539 signature motif; other site 446471008540 dimer interface [polypeptide binding]; other site 446471008541 polyP binding site; other site 446471008542 active site 446471008543 substrate binding site [chemical binding]; other site 446471008544 acceptor-phosphate pocket; other site 446471008545 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 446471008546 oligomeric interface; other site 446471008547 putative active site [active] 446471008548 homodimer interface [polypeptide binding]; other site 446471008549 Phd_YefM; Region: PhdYeFM; cl09153 446471008550 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446471008551 active site 446471008552 catalytic tetrad [active] 446471008553 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 446471008554 Predicted membrane protein [Function unknown]; Region: COG1511 446471008555 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446471008556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008557 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 446471008558 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446471008559 E3 interaction surface; other site 446471008560 lipoyl attachment site [posttranslational modification]; other site 446471008561 e3 binding domain; Region: E3_binding; pfam02817 446471008562 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 446471008563 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 446471008564 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446471008565 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446471008566 alpha subunit interface [polypeptide binding]; other site 446471008567 TPP binding site [chemical binding]; other site 446471008568 heterodimer interface [polypeptide binding]; other site 446471008569 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446471008570 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 446471008571 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446471008572 tetramer interface [polypeptide binding]; other site 446471008573 TPP-binding site [chemical binding]; other site 446471008574 heterodimer interface [polypeptide binding]; other site 446471008575 phosphorylation loop region [posttranslational modification] 446471008576 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 446471008577 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446471008578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471008579 homodimer interface [polypeptide binding]; other site 446471008580 catalytic residue [active] 446471008581 Membrane protein of unknown function; Region: DUF360; cl00850 446471008582 adenylosuccinate lyase; Provisional; Region: PRK09285 446471008583 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 446471008584 tetramer interface [polypeptide binding]; other site 446471008585 active site 446471008586 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 446471008587 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 446471008588 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 446471008589 Protein of unknown function (DUF805); Region: DUF805; cl01224 446471008590 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446471008591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471008592 dimer interface [polypeptide binding]; other site 446471008593 conserved gate region; other site 446471008594 putative PBP binding loops; other site 446471008595 ABC-ATPase subunit interface; other site 446471008596 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 446471008597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471008598 dimer interface [polypeptide binding]; other site 446471008599 conserved gate region; other site 446471008600 ABC-ATPase subunit interface; other site 446471008601 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446471008602 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446471008603 active site 446471008604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446471008605 non-specific DNA binding site [nucleotide binding]; other site 446471008606 salt bridge; other site 446471008607 sequence-specific DNA binding site [nucleotide binding]; other site 446471008608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446471008609 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 446471008610 active site 446471008611 motif I; other site 446471008612 motif II; other site 446471008613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446471008614 seryl-tRNA synthetase; Provisional; Region: PRK05431 446471008615 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 446471008616 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 446471008617 dimer interface [polypeptide binding]; other site 446471008618 active site 446471008619 motif 1; other site 446471008620 motif 2; other site 446471008621 motif 3; other site 446471008622 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 446471008623 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 446471008624 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446471008625 active site 446471008626 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446471008627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471008628 NAD(P) binding pocket [chemical binding]; other site 446471008629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471008630 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 446471008631 substrate binding site [chemical binding]; other site 446471008632 active site 446471008633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471008634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471008635 Fic family protein [Function unknown]; Region: COG3177 446471008636 Fic/DOC family; Region: Fic; cl00960 446471008637 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 446471008638 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 446471008639 domain interfaces; other site 446471008640 active site 446471008641 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 446471008642 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 446471008643 active site 446471008644 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 446471008645 dimer interface [polypeptide binding]; other site 446471008646 active site 446471008647 Schiff base residues; other site 446471008648 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 446471008649 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446471008650 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446471008651 catalytic residue [active] 446471008652 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 446471008653 putative homotetramer interface [polypeptide binding]; other site 446471008654 putative homodimer interface [polypeptide binding]; other site 446471008655 putative allosteric switch controlling residues; other site 446471008656 putative metal binding site [ion binding]; other site 446471008657 putative homodimer-homodimer interface [polypeptide binding]; other site 446471008658 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446471008659 metal-binding site [ion binding] 446471008660 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446471008661 metal-binding site [ion binding] 446471008662 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446471008663 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 446471008664 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 446471008665 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446471008666 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471008667 Walker A/P-loop; other site 446471008668 ATP binding site [chemical binding]; other site 446471008669 Q-loop/lid; other site 446471008670 ABC transporter signature motif; other site 446471008671 Walker B; other site 446471008672 D-loop; other site 446471008673 H-loop/switch region; other site 446471008674 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471008675 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 446471008676 Walker A/P-loop; other site 446471008677 ATP binding site [chemical binding]; other site 446471008678 Q-loop/lid; other site 446471008679 ABC transporter signature motif; other site 446471008680 Walker B; other site 446471008681 D-loop; other site 446471008682 H-loop/switch region; other site 446471008683 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446471008684 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446471008685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471008686 dimer interface [polypeptide binding]; other site 446471008687 conserved gate region; other site 446471008688 ABC-ATPase subunit interface; other site 446471008689 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446471008690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446471008691 dimer interface [polypeptide binding]; other site 446471008692 conserved gate region; other site 446471008693 putative PBP binding loops; other site 446471008694 ABC-ATPase subunit interface; other site 446471008695 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446471008696 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446471008697 Mn2+-dependent serine/threonine protein kinase [Signal transduction mechanisms]; Region: COG3642 446471008698 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 446471008699 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 446471008700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008701 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 446471008702 IHF dimer interface [polypeptide binding]; other site 446471008703 IHF - DNA interface [nucleotide binding]; other site 446471008704 Copper resistance protein CopC; Region: CopC; cl01012 446471008705 NAD synthetase; Reviewed; Region: nadE; PRK02628 446471008706 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 446471008707 active site 446471008708 catalytic triad [active] 446471008709 multimer interface [polypeptide binding]; other site 446471008710 protein interface 1 [polypeptide binding]; other site 446471008711 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 446471008712 homodimer interface [polypeptide binding]; other site 446471008713 NAD binding pocket [chemical binding]; other site 446471008714 ATP binding pocket [chemical binding]; other site 446471008715 Mg binding site [ion binding]; other site 446471008716 active-site loop [active] 446471008717 Clostridial hydrophobic W; Region: ChW; cl02763 446471008718 Clostridial hydrophobic W; Region: ChW; cl02763 446471008719 Clostridial hydrophobic W; Region: ChW; cl02763 446471008720 Clostridial hydrophobic W; Region: ChW; cl02763 446471008721 Clostridial hydrophobic W; Region: ChW; cl02763 446471008722 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 446471008723 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 446471008724 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446471008725 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 446471008726 Predicted ATPase [General function prediction only]; Region: COG3899 446471008727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471008728 DNA binding residues [nucleotide binding] 446471008729 dimerization interface [polypeptide binding]; other site 446471008730 GAF domain; Region: GAF; cl00853 446471008731 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 446471008732 RNA polymerase factor sigma-70; Validated; Region: PRK08241 446471008733 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471008734 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446471008735 DNA binding residues [nucleotide binding] 446471008736 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 446471008737 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 446471008738 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 446471008739 active site 446471008740 metal binding site 1 [ion binding]; metal-binding site 446471008741 putative 5' ssDNA interaction site; other site 446471008742 metal binding site 3; metal-binding site 446471008743 metal binding site 2 [ion binding]; metal-binding site 446471008744 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 446471008745 putative DNA binding site [nucleotide binding]; other site 446471008746 putative metal binding site [ion binding]; other site 446471008747 CrcB-like protein; Region: CRCB; cl09114 446471008748 CrcB-like protein; Region: CRCB; cl09114 446471008749 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446471008750 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446471008751 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 446471008752 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 446471008753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471008754 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446471008755 NAD(P) binding site [chemical binding]; other site 446471008756 active site 446471008757 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 446471008758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471008759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446471008760 DNA binding residues [nucleotide binding] 446471008761 YceI-like domain; Region: YceI; cl01001 446471008762 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 446471008763 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 446471008764 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 446471008765 AP (apurinic/apyrimidinic) site pocket; other site 446471008766 DNA interaction; other site 446471008767 Metal-binding active site; metal-binding site 446471008768 DinB superfamily; Region: DinB_2; cl00986 446471008769 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446471008770 homotrimer interaction site [polypeptide binding]; other site 446471008771 putative active site [active] 446471008772 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446471008773 active site 446471008774 metal binding site [ion binding]; metal-binding site 446471008775 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 446471008776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446471008777 S-adenosylmethionine binding site [chemical binding]; other site 446471008778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008779 putative transposase OrfB; Reviewed; Region: PHA02517 446471008780 Integrase core domain; Region: rve; cl01316 446471008781 RNA polymerase sigma factor; Provisional; Region: PRK12519 446471008782 ornithine cyclodeaminase; Validated; Region: PRK07589 446471008783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471008784 Amidinotransferase; Region: Amidinotransf; cl12043 446471008785 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 446471008786 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446471008787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446471008789 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 446471008790 active site 446471008791 motif I; other site 446471008792 motif II; other site 446471008793 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 446471008794 YibE/F-like protein; Region: YibE_F; cl02259 446471008795 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 446471008796 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 446471008797 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 446471008798 heme binding site [chemical binding]; other site 446471008799 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 446471008800 heme binding site [chemical binding]; other site 446471008801 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446471008802 metal binding site 2 [ion binding]; metal-binding site 446471008803 putative DNA binding helix; other site 446471008804 metal binding site 1 [ion binding]; metal-binding site 446471008805 dimer interface [polypeptide binding]; other site 446471008806 structural Zn2+ binding site [ion binding]; other site 446471008807 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446471008808 active site 446471008809 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 446471008810 MgtE intracellular N domain; Region: MgtE_N; cl15244 446471008811 FOG: CBS domain [General function prediction only]; Region: COG0517 446471008812 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 446471008813 Divalent cation transporter; Region: MgtE; cl00786 446471008814 Phosphotransferase enzyme family; Region: APH; pfam01636 446471008815 Predicted kinase [General function prediction only]; Region: COG0645 446471008816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471008817 active site 446471008818 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 446471008819 putative dimer interface [polypeptide binding]; other site 446471008820 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446471008821 ABC-2 type transporter; Region: ABC2_membrane; cl11417 446471008822 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446471008823 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 446471008824 Walker A/P-loop; other site 446471008825 ATP binding site [chemical binding]; other site 446471008826 Q-loop/lid; other site 446471008827 ABC transporter signature motif; other site 446471008828 Walker B; other site 446471008829 D-loop; other site 446471008830 H-loop/switch region; other site 446471008831 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446471008832 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 446471008833 Walker A/P-loop; other site 446471008834 ATP binding site [chemical binding]; other site 446471008835 Q-loop/lid; other site 446471008836 ABC transporter signature motif; other site 446471008837 Walker B; other site 446471008838 D-loop; other site 446471008839 H-loop/switch region; other site 446471008840 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446471008841 DNA-binding site [nucleotide binding]; DNA binding site 446471008842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446471008843 Histidine kinase; Region: HisKA_3; pfam07730 446471008844 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446471008845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446471008846 active site 446471008847 phosphorylation site [posttranslational modification] 446471008848 intermolecular recognition site; other site 446471008849 dimerization interface [polypeptide binding]; other site 446471008850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446471008851 DNA binding residues [nucleotide binding] 446471008852 dimerization interface [polypeptide binding]; other site 446471008853 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 446471008854 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 446471008855 catalytic triad [active] 446471008856 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 446471008857 putative active site [active] 446471008858 Phd_YefM; Region: PhdYeFM; cl09153 446471008859 Amino acid permease; Region: AA_permease; cl00524 446471008860 Cation efflux family; Region: Cation_efflux; cl00316 446471008861 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 446471008862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008863 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 446471008864 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446471008865 putative NAD(P) binding site [chemical binding]; other site 446471008866 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 446471008867 putative dimer interface [polypeptide binding]; other site 446471008868 catalytic triad [active] 446471008869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008870 Predicted transcriptional regulator [Transcription]; Region: COG2378 446471008871 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446471008872 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446471008873 tetracycline repressor protein TetR; Provisional; Region: PRK13756 446471008874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471008876 putative substrate translocation pore; other site 446471008877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446471008878 dimerization interface [polypeptide binding]; other site 446471008879 putative DNA binding site [nucleotide binding]; other site 446471008880 putative Zn2+ binding site [ion binding]; other site 446471008881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446471008882 putative DNA binding site [nucleotide binding]; other site 446471008883 dimerization interface [polypeptide binding]; other site 446471008884 putative Zn2+ binding site [ion binding]; other site 446471008885 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446471008886 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 446471008887 active site 446471008888 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 446471008889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471008890 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446471008891 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 446471008892 active site residue [active] 446471008893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446471008894 S-adenosylmethionine binding site [chemical binding]; other site 446471008895 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446471008896 dimerization interface [polypeptide binding]; other site 446471008897 putative DNA binding site [nucleotide binding]; other site 446471008898 putative Zn2+ binding site [ion binding]; other site 446471008899 replicative DNA helicase; Region: DnaB; TIGR00665 446471008900 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446471008901 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 446471008902 Walker A motif; other site 446471008903 ATP binding site [chemical binding]; other site 446471008904 Walker B motif; other site 446471008905 DNA binding loops [nucleotide binding] 446471008906 putative efflux protein, MATE family; Region: matE; TIGR00797 446471008907 MatE; Region: MatE; cl10513 446471008908 MatE; Region: MatE; cl10513 446471008909 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 446471008910 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 446471008911 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 446471008912 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 446471008913 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446471008914 dimer interface [polypeptide binding]; other site 446471008915 ssDNA binding site [nucleotide binding]; other site 446471008916 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446471008917 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 446471008918 Transglycosylase; Region: Transgly; cl07896 446471008919 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446471008920 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 446471008921 Transglycosylase; Region: Transgly; cl07896 446471008922 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446471008923 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 446471008924 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446471008925 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 446471008926 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 446471008927 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446471008928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446471008929 putative substrate translocation pore; other site 446471008930 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 446471008931 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 446471008932 active site 446471008933 NTP binding site [chemical binding]; other site 446471008934 metal binding triad [ion binding]; metal-binding site 446471008935 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 446471008936 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 446471008937 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 446471008938 active site 446471008939 Ap6A binding site [chemical binding]; other site 446471008940 nudix motif; other site 446471008941 metal binding site [ion binding]; metal-binding site 446471008942 integral membrane protein MviN; Region: mviN; TIGR01695 446471008943 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 446471008944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446471008945 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446471008946 catalytic residues [active] 446471008947 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 446471008948 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446471008949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446471008950 homodimer interface [polypeptide binding]; other site 446471008951 catalytic residue [active] 446471008952 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 446471008953 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446471008954 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 446471008955 ParB-like partition proteins; Region: parB_part; TIGR00180 446471008956 ParB-like nuclease domain; Region: ParBc; cl02129 446471008957 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446471008958 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446471008959 Magnesium ion binding site [ion binding]; other site 446471008960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471008961 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 446471008962 G-X-X-G motif; other site 446471008963 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 446471008964 RxxxH motif; other site 446471008965 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 446471008966 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 446471008967 Domain of unknown function DUF37; Region: DUF37; cl00506 446471008968 Ribonuclease P; Region: Ribonuclease_P; cl00457 446471008969 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 446471008970 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 446471008971 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 446471008972 Active Sites [active] 446471008973 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 446471008974 Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231 446471008975 CHC2 zinc finger; Region: zf-CHC2; cl15369 446471008976 hypothetical protein; Validated; Region: PRK07078 446471008977 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 446471008978 active site 446471008979 metal binding site [ion binding]; metal-binding site 446471008980 interdomain interaction site; other site 446471008981 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 446471008982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471008983 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446471008984 Magnesium ion binding site [ion binding]; other site 446471008985 SAF domain; Region: SAF; cl00555 446471008986 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 446471008987 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471008988 Walker A motif; other site 446471008989 ATP binding site [chemical binding]; other site 446471008990 Walker B motif; other site 446471008991 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 446471008992 TadE-like protein; Region: TadE; pfam07811 446471008993 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 446471008994 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 446471008995 ribonuclease E; Reviewed; Region: rne; PRK10811 446471008996 Bacterial transcriptional activator domain; Region: BTAD; smart01043 446471008997 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 446471008998 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 446471008999 active site 446471009000 substrate binding site [chemical binding]; other site 446471009001 trimer interface [polypeptide binding]; other site 446471009002 CoA binding site [chemical binding]; other site 446471009003 Uncharacterized protein conserved in archaea (DUF2180); Region: DUF2180; cl02017 446471009004 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 446471009005 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 446471009006 AAA-like domain; Region: AAA_10; pfam12846 446471009007 Peptidase family M23; Region: Peptidase_M23; pfam01551 446471009008 NlpC/P60 family; Region: NLPC_P60; cl11438 446471009009 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 446471009010 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471009011 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 446471009012 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 446471009013 catalytic residues [active] 446471009014 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 446471009015 Transcription factor WhiB; Region: Whib; pfam02467 446471009016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 446471009017 cofactor binding site; other site 446471009018 DNA binding site [nucleotide binding] 446471009019 substrate interaction site [chemical binding]; other site 446471009020 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 446471009021 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446471009022 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446471009023 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 446471009024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 446471009025 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 446471009026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446471009027 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 446471009028 Walker A motif; other site 446471009029 ATP binding site [chemical binding]; other site 446471009030 Walker B motif; other site 446471009031 arginine finger; other site 446471009032 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446471009033 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112