-- dump date 20140620_140816 -- class Genbank::misc_feature -- table misc_feature_note -- id note 360102000001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102000002 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102000003 DNA-binding interface [nucleotide binding]; DNA binding site 360102000004 Integrase core domain; Region: rve; pfam00665 360102000005 transposase/IS protein; Provisional; Region: PRK09183 360102000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102000007 Walker A motif; other site 360102000008 ATP binding site [chemical binding]; other site 360102000009 Walker B motif; other site 360102000010 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 360102000011 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 360102000012 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 360102000013 Phage Tail Collar Domain; Region: Collar; pfam07484 360102000014 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 360102000015 Phage-related protein, tail component [Function unknown]; Region: COG4733 360102000016 Putative phage tail protein; Region: Phage-tail_3; pfam13550 360102000017 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 360102000018 Interdomain contacts; other site 360102000019 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 360102000020 Fibronectin type III protein; Region: DUF3672; pfam12421 360102000021 Phage-related protein, tail component [Function unknown]; Region: COG4723 360102000022 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 360102000023 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 360102000024 NlpC/P60 family; Region: NLPC_P60; pfam00877 360102000025 lambda-like phage minor tail protein L; Region: phage_tail_L; TIGR01600 360102000026 Phage-related protein [Function unknown]; Region: COG4718 360102000027 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 360102000028 Mu-like prophage protein [General function prediction only]; Region: COG3941 360102000029 tape measure domain; Region: tape_meas_nterm; TIGR02675 360102000030 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 360102000031 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 360102000032 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 360102000033 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 360102000034 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 360102000035 large terminase protein; Provisional; Region: 17; PHA02533 360102000036 Terminase-like family; Region: Terminase_6; pfam03237 360102000037 ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Region: COG2401 360102000038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102000039 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 360102000040 Walker A/P-loop; other site 360102000041 ATP binding site [chemical binding]; other site 360102000042 Q-loop/lid; other site 360102000043 ABC transporter signature motif; other site 360102000044 Walker B; other site 360102000045 D-loop; other site 360102000046 H-loop/switch region; other site 360102000047 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 360102000048 ParB-like nuclease domain; Region: ParBc; pfam02195 360102000049 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 360102000050 ParB-like nuclease domain; Region: ParBc; pfam02195 360102000051 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 360102000052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360102000053 ATP binding site [chemical binding]; other site 360102000054 putative Mg++ binding site [ion binding]; other site 360102000055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102000056 nucleotide binding region [chemical binding]; other site 360102000057 ATP-binding site [chemical binding]; other site 360102000058 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 360102000059 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 360102000060 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 360102000061 Protein of unknown function (DUF327); Region: DUF327; cl00753 360102000062 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102000063 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 360102000064 active site 360102000065 putative DNA-binding cleft [nucleotide binding]; other site 360102000066 dimer interface [polypeptide binding]; other site 360102000067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102000068 endonuclease subunit; Provisional; Region: 46; PHA02562 360102000069 Walker A/P-loop; other site 360102000070 ATP binding site [chemical binding]; other site 360102000071 Q-loop/lid; other site 360102000072 ABC transporter signature motif; other site 360102000073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102000074 ABC transporter signature motif; other site 360102000075 Walker B; other site 360102000076 D-loop; other site 360102000077 H-loop/switch region; other site 360102000078 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 360102000079 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 360102000080 active site 360102000081 metal binding site [ion binding]; metal-binding site 360102000082 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 360102000083 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 360102000084 Initiator Replication protein; Region: Rep_3; cl03080 360102000085 hypothetical protein; Region: PHA02053 360102000086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102000087 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102000088 DNA-binding interface [nucleotide binding]; DNA binding site 360102000089 Integrase core domain; Region: rve; pfam00665 360102000090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102000091 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 360102000092 Walker A motif; other site 360102000093 ATP binding site [chemical binding]; other site 360102000094 Walker B motif; other site 360102000095 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 360102000096 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 360102000097 SPFH domain / Band 7 family; Region: Band_7; pfam01145 360102000098 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 360102000099 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 360102000100 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 360102000101 Walker A motif; other site 360102000102 ATP binding site [chemical binding]; other site 360102000103 Walker B motif; other site 360102000104 PIN domain of bacteriophage T3, T4 RNase H, T5-5'nuclease, and homologs; Region: PIN_T4-like; cd09860 360102000105 5'-3' exonuclease; Region: 53EXOc; smart00475 360102000106 active site 360102000107 metal binding site 1 [ion binding]; metal-binding site 360102000108 5' ssDNA interaction site; other site 360102000109 3' ssDNA interaction site; other site 360102000110 metal binding site 2 [ion binding]; metal-binding site 360102000111 H3TH domain of bacteriophage T3, T4 RNase H, T5-5' nucleases, and homologs; Region: H3TH_T4-like; cd09899 360102000112 DNA binding site [nucleotide binding] 360102000113 metal binding site [ion binding]; metal-binding site 360102000114 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 360102000115 PHP domain; Region: PHP; pfam02811 360102000116 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 360102000117 active site 360102000118 PHP Thumb interface [polypeptide binding]; other site 360102000119 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 360102000120 Uracil DNA glycosylase superfamily; Region: UDG; pfam03167 360102000121 MoxR-like ATPases [General function prediction only]; Region: COG0714 360102000122 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 360102000123 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 360102000124 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 360102000125 Cobalamin biosynthesis protein CobT VWA domain; Region: CobT_C; pfam11775 360102000126 metal ion-dependent adhesion site (MIDAS); other site 360102000127 transposase/IS protein; Provisional; Region: PRK09183 360102000128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102000129 Walker A motif; other site 360102000130 ATP binding site [chemical binding]; other site 360102000131 Walker B motif; other site 360102000132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102000133 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102000134 DNA-binding interface [nucleotide binding]; DNA binding site 360102000135 Integrase core domain; Region: rve; pfam00665 360102000136 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 360102000137 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360102000138 DNA binding site [nucleotide binding] 360102000139 active site 360102000140 Int/Topo IB signature motif; other site 360102000141 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360102000142 Caf1 Capsule antigen; Region: Antig_Caf1; pfam09255 360102000143 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 360102000144 PapC N-terminal domain; Region: PapC_N; pfam13954 360102000145 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102000146 PapC C-terminal domain; Region: PapC_C; pfam13953 360102000147 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 360102000148 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102000149 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 360102000150 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 360102000151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102000152 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 360102000153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102000154 MULE transposase domain; Region: MULE; pfam10551 360102000155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 360102000156 Transposase; Region: DEDD_Tnp_IS110; pfam01548 360102000157 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 360102000158 Uncharacterized conserved protein [Function unknown]; Region: COG5464 360102000159 putative transposase OrfB; Reviewed; Region: PHA02517 360102000160 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 360102000161 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 360102000162 Putative catalytic domain, repeat 1, of Yersinia pestis murine toxin-like proteins; Region: PLDc_Ymt_1; cd09150 360102000163 putative active site [active] 360102000164 catalytic site [active] 360102000165 Putative catalytic domain, repeat 2, of Yersinia pestis murine toxin-like proteins; Region: PLDc_Ymt_2; cd09151 360102000166 PLD-like domain; Region: PLDc_2; pfam13091 360102000167 putative active site [active] 360102000168 catalytic site [active] 360102000169 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 360102000170 PLD-like domain; Region: PLDc_2; pfam13091 360102000171 putative active site [active] 360102000172 catalytic site [active] 360102000173 Uncharacterized conserved protein [Function unknown]; Region: COG5464 360102000174 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 360102000175 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 360102000176 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 360102000177 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 360102000178 catalytic residues [active] 360102000179 catalytic nucleophile [active] 360102000180 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 360102000181 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 360102000182 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 360102000183 P-loop; other site 360102000184 Magnesium ion binding site [ion binding]; other site 360102000185 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 360102000186 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 360102000187 ParB-like nuclease domain; Region: ParB; smart00470 360102000188 ParB family; Region: ParB; pfam08775 360102000189 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 360102000190 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 360102000191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102000192 Walker A motif; other site 360102000193 ATP binding site [chemical binding]; other site 360102000194 Walker B motif; other site 360102000195 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 360102000196 putative methylase; Provisional; Region: PRK13699 360102000197 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 360102000198 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 360102000199 Antirestriction protein [General function prediction only]; Region: ArdA; COG4734 360102000200 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 360102000201 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 360102000202 ParB-like nuclease domain; Region: ParBc; pfam02195 360102000203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102000204 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102000205 DNA-binding interface [nucleotide binding]; DNA binding site 360102000206 Integrase core domain; Region: rve; pfam00665 360102000207 transposase/IS protein; Provisional; Region: PRK09183 360102000208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102000209 Walker A motif; other site 360102000210 ATP binding site [chemical binding]; other site 360102000211 Walker B motif; other site 360102000212 Rop protein; Region: Rop; pfam01815 360102000213 Rop protein; Region: Rop; pfam01815 360102000214 Pesticin Translocation And Receptor Binding Domain; Region: Pesticin_RB; cd12220 360102000215 TonB box [polypeptide binding]; other site 360102000216 outer membrane protease; Reviewed; Region: PRK12580 360102000217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360102000218 non-specific DNA binding site [nucleotide binding]; other site 360102000219 salt bridge; other site 360102000220 sequence-specific DNA binding site [nucleotide binding]; other site 360102000221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 360102000222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102000223 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102000224 DNA-binding interface [nucleotide binding]; DNA binding site 360102000225 Integrase core domain; Region: rve; pfam00665 360102000226 transposase/IS protein; Provisional; Region: PRK09183 360102000227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102000228 Walker A motif; other site 360102000229 ATP binding site [chemical binding]; other site 360102000230 Walker B motif; other site 360102000231 Transposase; Region: HTH_Tnp_1; pfam01527 360102000232 YopH, N-terminal; Region: YopH_N; pfam09013 360102000233 type III secretion system protein; Reviewed; Region: PRK06937 360102000234 Flagellar assembly protein FliH; Region: FliH; pfam02108 360102000235 YOP proteins translocation protein K (YscK); Region: YscK; pfam06578 360102000236 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 360102000237 type III secretion apparatus protein, YscI/HrpB, C-terminal domain; Region: yscI_hrpB_dom; TIGR02497 360102000238 type III secretion effector, YopR family; Region: type_III_yopR; TIGR02509 360102000239 type III secretion protein, YscG family; Region: type_III_yscG; TIGR02508 360102000240 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 360102000241 Protein of unknown function (DUF1895); Region: DUF1895; pfam08988 360102000242 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 360102000243 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 360102000244 phosphopeptide binding site; other site 360102000245 type III secretion system protein SsaD; Provisional; Region: PRK15367 360102000246 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 360102000247 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 360102000248 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 360102000249 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 360102000250 type III secretion system chaperone, YscB family; Region: type_III_yscB; TIGR02513 360102000251 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 360102000252 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 360102000253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102000254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102000255 Type III secretory pathway, component EscU [Intracellular trafficking and secretion]; Region: EscU; COG4792 360102000256 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 360102000257 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 360102000258 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 360102000259 type III secretion system protein; Validated; Region: PRK06933 360102000260 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 360102000261 type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514 360102000262 Type III secretion protein YscO; Region: YscO; pfam07321 360102000263 type III secretion system ATPase; Provisional; Region: PRK06936 360102000264 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 360102000265 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 360102000266 Walker A motif/ATP binding site; other site 360102000267 Walker B motif; other site 360102000268 HrpJ-like domain; Region: HrpJ; cl15454 360102000269 TyeA; Region: TyeA; pfam09059 360102000270 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 360102000271 type III secretion protein, YscX family; Region: type_III_YscX; TIGR02502 360102000272 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 360102000273 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 360102000274 FHIPEP family; Region: FHIPEP; pfam00771 360102000275 Type III secretion system regulator (LcrR); Region: LcrR; cl09838 360102000276 type III secretion protein LcrG; Region: LcrG_PcrG; TIGR02573 360102000277 V antigen (LcrV) protein; Region: LcrV; pfam04792 360102000278 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 360102000279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360102000280 binding surface 360102000281 TPR motif; other site 360102000282 Uncharacterized conserved protein [Function unknown]; Region: COG5613 360102000283 YopD protein; Region: YopD; pfam05844 360102000284 Integrase core domain; Region: rve; pfam00665 360102000285 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 360102000286 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 360102000287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102000288 DDE domain; Region: DDE_Tnp_IS240; pfam13610 360102000289 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 360102000290 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; pfam03543 360102000291 glycine dehydrogenase; Provisional; Region: PRK12566 360102000292 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 360102000293 Transposase; Region: HTH_Tnp_1; pfam01527 360102000294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 360102000295 HTH-like domain; Region: HTH_21; pfam13276 360102000296 Integrase core domain; Region: rve; pfam00665 360102000297 Integrase core domain; Region: rve_3; cl15866 360102000298 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 360102000299 MerR family regulatory protein; Region: MerR; pfam00376 360102000300 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 360102000301 P-loop; other site 360102000302 Magnesium ion binding site [ion binding]; other site 360102000303 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 360102000304 Magnesium ion binding site [ion binding]; other site 360102000305 plasmid-partitioning protein; Provisional; Region: PRK13698 360102000306 ParB-like nuclease domain; Region: ParB; smart00470 360102000307 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 360102000308 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 360102000309 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 360102000310 YopE, N terminal; Region: YopE_N; pfam09020 360102000311 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 360102000312 switch II binding region; other site 360102000313 Rac1 P-loop interaction site [polypeptide binding]; other site 360102000314 GTP binding residues [chemical binding]; other site 360102000315 switch I binding region; other site 360102000316 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 360102000317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 360102000318 Integrase core domain; Region: rve; pfam00665 360102000319 Integrase core domain; Region: rve_3; pfam13683 360102000320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102000321 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 360102000322 Integrase core domain; Region: rve; pfam00665 360102000323 Integrase core domain; Region: rve_3; cl15866 360102000324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 360102000325 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 360102000326 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 360102000327 HTH-like domain; Region: HTH_21; pfam13276 360102000328 Integrase core domain; Region: rve; pfam00665 360102000329 Integrase core domain; Region: rve_3; pfam13683 360102000330 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102000331 DNA-binding interface [nucleotide binding]; DNA binding site 360102000332 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 360102000333 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 360102000334 catalytic residues [active] 360102000335 catalytic nucleophile [active] 360102000336 Presynaptic Site I dimer interface [polypeptide binding]; other site 360102000337 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 360102000338 Synaptic Flat tetramer interface [polypeptide binding]; other site 360102000339 Synaptic Site I dimer interface [polypeptide binding]; other site 360102000340 DNA binding site [nucleotide binding] 360102000341 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102000342 DNA-binding interface [nucleotide binding]; DNA binding site 360102000343 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 360102000344 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 360102000345 HTH-like domain; Region: HTH_21; pfam13276 360102000346 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 360102000347 trimer interface [polypeptide binding]; other site 360102000348 Haemagglutinin; Region: HIM; pfam05662 360102000349 YadA-like C-terminal region; Region: YadA; pfam03895 360102000350 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 360102000351 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 360102000352 Transposase; Region: HTH_Tnp_1; pfam01527 360102000353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 360102000354 HTH-like domain; Region: HTH_21; pfam13276 360102000355 Integrase core domain; Region: rve; pfam00665 360102000356 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 360102000357 PLD-like domain; Region: PLDc_2; pfam13091 360102000358 putative active site [active] 360102000359 catalytic site [active] 360102000360 replication protein; Provisional; Region: PRK13702 360102000361 replication protein; Provisional; Region: PRK13750 360102000362 Integrase core domain; Region: rve; pfam00665 360102000363 Tir chaperone protein (CesT); Region: CesT; cl08444 360102000364 Protein kinase domain; Region: Pkinase; pfam00069 360102000365 Catalytic domain of Protein Kinases; Region: PKc; cd00180 360102000366 active site 360102000367 ATP binding site [chemical binding]; other site 360102000368 substrate binding site [chemical binding]; other site 360102000369 activation loop (A-loop); other site 360102000370 Rac1-binding domain; Region: Rac1; pfam09632 360102000371 effector protein YopJ; Provisional; Region: PRK15371 360102000372 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 360102000373 Integrase core domain; Region: rve; pfam00665 360102000374 Integrase core domain; Region: rve_3; pfam13683 360102000375 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 360102000376 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 360102000377 YopH, N-terminal; Region: YopH_N; pfam09013 360102000378 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 360102000379 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 360102000380 active site 360102000381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102000382 Integrase core domain; Region: rve; pfam00665 360102000383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 360102000384 Integrase core domain; Region: rve_3; pfam13683 360102000385 FMN-binding protein MioC; Provisional; Region: PRK09004 360102000386 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 360102000387 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360102000388 putative DNA binding site [nucleotide binding]; other site 360102000389 putative Zn2+ binding site [ion binding]; other site 360102000390 AsnC family; Region: AsnC_trans_reg; pfam01037 360102000391 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 360102000392 motif 1; other site 360102000393 dimer interface [polypeptide binding]; other site 360102000394 active site 360102000395 motif 2; other site 360102000396 motif 3; other site 360102000397 hypothetical protein; Provisional; Region: yieM; PRK10997 360102000398 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 360102000399 metal ion-dependent adhesion site (MIDAS); other site 360102000400 regulatory ATPase RavA; Provisional; Region: PRK13531 360102000401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102000402 Walker A motif; other site 360102000403 ATP binding site [chemical binding]; other site 360102000404 Walker B motif; other site 360102000405 arginine finger; other site 360102000406 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 360102000407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102000408 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102000409 DNA-binding interface [nucleotide binding]; DNA binding site 360102000410 Integrase core domain; Region: rve; pfam00665 360102000411 transposase/IS protein; Provisional; Region: PRK09183 360102000412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102000413 Walker A motif; other site 360102000414 ATP binding site [chemical binding]; other site 360102000415 Walker B motif; other site 360102000416 regulatory ATPase RavA; Provisional; Region: PRK13531 360102000417 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 360102000418 potassium uptake protein; Region: kup; TIGR00794 360102000419 D-ribose pyranase; Provisional; Region: PRK11797 360102000420 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360102000421 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 360102000422 substrate binding site [chemical binding]; other site 360102000423 dimer interface [polypeptide binding]; other site 360102000424 ATP binding site [chemical binding]; other site 360102000425 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 360102000426 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 360102000427 putative transporter; Provisional; Region: PRK10504 360102000428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102000429 putative substrate translocation pore; other site 360102000430 Transcriptional regulators [Transcription]; Region: FadR; COG2186 360102000431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360102000432 DNA-binding site [nucleotide binding]; DNA binding site 360102000433 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 360102000434 homoserine O-succinyltransferase; Provisional; Region: PRK05368 360102000435 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 360102000436 proposed active site lysine [active] 360102000437 conserved cys residue [active] 360102000438 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 360102000439 malate synthase A; Region: malate_syn_A; TIGR01344 360102000440 active site 360102000441 isocitrate lyase; Provisional; Region: PRK15063 360102000442 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 360102000443 tetramer interface [polypeptide binding]; other site 360102000444 active site 360102000445 Mg2+/Mn2+ binding site [ion binding]; other site 360102000446 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 360102000447 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 360102000448 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 360102000449 Bacterial transcriptional regulator; Region: IclR; pfam01614 360102000450 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 360102000451 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 360102000452 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 360102000453 substrate binding pocket [chemical binding]; other site 360102000454 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 360102000455 B12 binding site [chemical binding]; other site 360102000456 cobalt ligand [ion binding]; other site 360102000457 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 360102000458 haemagglutination activity domain; Region: Haemagg_act; pfam05860 360102000459 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102000460 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102000461 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 360102000462 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102000463 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102000464 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102000465 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 360102000466 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 360102000467 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 360102000468 aspartate kinase III; Validated; Region: PRK09084 360102000469 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 360102000470 nucleotide binding site [chemical binding]; other site 360102000471 substrate binding site [chemical binding]; other site 360102000472 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 360102000473 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 360102000474 dimer interface [polypeptide binding]; other site 360102000475 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 360102000476 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 360102000477 active site 360102000478 dimer interface [polypeptide binding]; other site 360102000479 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 360102000480 dimer interface [polypeptide binding]; other site 360102000481 active site 360102000482 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 360102000483 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360102000484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102000485 dimer interface [polypeptide binding]; other site 360102000486 conserved gate region; other site 360102000487 putative PBP binding loops; other site 360102000488 ABC-ATPase subunit interface; other site 360102000489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102000490 dimer interface [polypeptide binding]; other site 360102000491 conserved gate region; other site 360102000492 putative PBP binding loops; other site 360102000493 ABC-ATPase subunit interface; other site 360102000494 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 360102000495 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 360102000496 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 360102000497 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 360102000498 Walker A/P-loop; other site 360102000499 ATP binding site [chemical binding]; other site 360102000500 Q-loop/lid; other site 360102000501 ABC transporter signature motif; other site 360102000502 Walker B; other site 360102000503 D-loop; other site 360102000504 H-loop/switch region; other site 360102000505 TOBE domain; Region: TOBE_2; pfam08402 360102000506 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 360102000507 trimer interface; other site 360102000508 sugar binding site [chemical binding]; other site 360102000509 maltose regulon periplasmic protein; Provisional; Region: PRK10564 360102000510 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 360102000511 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 360102000512 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 360102000513 Protein of unknown function (DUF877); Region: DUF877; pfam05943 360102000514 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 360102000515 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 360102000516 putative transposase OrfB; Reviewed; Region: PHA02517 360102000517 HTH-like domain; Region: HTH_21; pfam13276 360102000518 Integrase core domain; Region: rve; pfam00665 360102000519 Integrase core domain; Region: rve_2; pfam13333 360102000520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 360102000521 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102000522 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102000523 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 360102000524 16S/18S rRNA binding site [nucleotide binding]; other site 360102000525 S13e-L30e interaction site [polypeptide binding]; other site 360102000526 25S rRNA binding site [nucleotide binding]; other site 360102000527 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 360102000528 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 360102000529 RNA binding site [nucleotide binding]; other site 360102000530 active site 360102000531 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 360102000532 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 360102000533 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 360102000534 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 360102000535 translation initiation factor IF-2; Validated; Region: infB; PRK05306 360102000536 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 360102000537 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 360102000538 G1 box; other site 360102000539 putative GEF interaction site [polypeptide binding]; other site 360102000540 GTP/Mg2+ binding site [chemical binding]; other site 360102000541 Switch I region; other site 360102000542 G2 box; other site 360102000543 G3 box; other site 360102000544 Switch II region; other site 360102000545 G4 box; other site 360102000546 G5 box; other site 360102000547 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 360102000548 Translation-initiation factor 2; Region: IF-2; pfam11987 360102000549 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 360102000550 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 360102000551 NusA N-terminal domain; Region: NusA_N; pfam08529 360102000552 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 360102000553 RNA binding site [nucleotide binding]; other site 360102000554 homodimer interface [polypeptide binding]; other site 360102000555 NusA-like KH domain; Region: KH_5; pfam13184 360102000556 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 360102000557 G-X-X-G motif; other site 360102000558 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 360102000559 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 360102000560 ribosome maturation protein RimP; Reviewed; Region: PRK00092 360102000561 Sm and related proteins; Region: Sm_like; cl00259 360102000562 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 360102000563 putative oligomer interface [polypeptide binding]; other site 360102000564 putative RNA binding site [nucleotide binding]; other site 360102000565 Preprotein translocase SecG subunit; Region: SecG; pfam03840 360102000566 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 360102000567 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 360102000568 active site 360102000569 substrate binding site [chemical binding]; other site 360102000570 metal binding site [ion binding]; metal-binding site 360102000571 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 360102000572 dihydropteroate synthase; Region: DHPS; TIGR01496 360102000573 substrate binding pocket [chemical binding]; other site 360102000574 dimer interface [polypeptide binding]; other site 360102000575 inhibitor binding site; inhibition site 360102000576 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 360102000577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102000578 Walker A motif; other site 360102000579 ATP binding site [chemical binding]; other site 360102000580 Walker B motif; other site 360102000581 arginine finger; other site 360102000582 Peptidase family M41; Region: Peptidase_M41; pfam01434 360102000583 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 360102000584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102000585 S-adenosylmethionine binding site [chemical binding]; other site 360102000586 RNA-binding protein YhbY; Provisional; Region: PRK10343 360102000587 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 360102000588 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 360102000589 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 360102000590 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 360102000591 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 360102000592 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 360102000593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102000594 active site 360102000595 phosphorylation site [posttranslational modification] 360102000596 intermolecular recognition site; other site 360102000597 dimerization interface [polypeptide binding]; other site 360102000598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102000599 DNA binding site [nucleotide binding] 360102000600 sensor protein BasS/PmrB; Provisional; Region: PRK10755 360102000601 HAMP domain; Region: HAMP; pfam00672 360102000602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102000603 dimer interface [polypeptide binding]; other site 360102000604 phosphorylation site [posttranslational modification] 360102000605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102000606 ATP binding site [chemical binding]; other site 360102000607 Mg2+ binding site [ion binding]; other site 360102000608 G-X-G motif; other site 360102000609 GTPase CgtA; Reviewed; Region: obgE; PRK12298 360102000610 GTP1/OBG; Region: GTP1_OBG; pfam01018 360102000611 Obg GTPase; Region: Obg; cd01898 360102000612 G1 box; other site 360102000613 GTP/Mg2+ binding site [chemical binding]; other site 360102000614 Switch I region; other site 360102000615 G2 box; other site 360102000616 G3 box; other site 360102000617 Switch II region; other site 360102000618 G4 box; other site 360102000619 G5 box; other site 360102000620 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 360102000621 EamA-like transporter family; Region: EamA; pfam00892 360102000622 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 360102000623 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 360102000624 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 360102000625 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 360102000626 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 360102000627 substrate binding pocket [chemical binding]; other site 360102000628 chain length determination region; other site 360102000629 substrate-Mg2+ binding site; other site 360102000630 catalytic residues [active] 360102000631 aspartate-rich region 1; other site 360102000632 active site lid residues [active] 360102000633 aspartate-rich region 2; other site 360102000634 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 360102000635 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 360102000636 malate dehydrogenase; Provisional; Region: PRK05086 360102000637 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 360102000638 NAD binding site [chemical binding]; other site 360102000639 dimerization interface [polypeptide binding]; other site 360102000640 Substrate binding site [chemical binding]; other site 360102000641 arginine repressor; Provisional; Region: PRK05066 360102000642 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 360102000643 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 360102000644 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 360102000645 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 360102000646 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360102000647 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360102000648 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360102000649 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 360102000650 AMP binding site [chemical binding]; other site 360102000651 metal binding site [ion binding]; metal-binding site 360102000652 active site 360102000653 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 360102000654 dimer interface [polypeptide binding]; other site 360102000655 substrate binding site [chemical binding]; other site 360102000656 metal binding sites [ion binding]; metal-binding site 360102000657 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 360102000658 putative active site pocket [active] 360102000659 dimerization interface [polypeptide binding]; other site 360102000660 putative catalytic residue [active] 360102000661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 360102000662 Family of unknown function (DUF490); Region: DUF490; pfam04357 360102000663 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 360102000664 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 360102000665 Surface antigen; Region: Bac_surface_Ag; pfam01103 360102000666 methionine sulfoxide reductase A; Provisional; Region: PRK00058 360102000667 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 360102000668 Domain of unknown function DUF21; Region: DUF21; pfam01595 360102000669 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 360102000670 Transporter associated domain; Region: CorC_HlyC; smart01091 360102000671 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 360102000672 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 360102000673 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 360102000674 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 360102000675 active site 360102000676 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 360102000677 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 360102000678 active site 360102000679 metal binding site [ion binding]; metal-binding site 360102000680 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 360102000681 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 360102000682 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 360102000683 Hemerythrin-like domain; Region: Hr-like; cd12108 360102000684 Fe binding site [ion binding]; other site 360102000685 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 360102000686 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 360102000687 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 360102000688 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 360102000689 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 360102000690 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 360102000691 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102000692 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 360102000693 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 360102000694 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 360102000695 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 360102000696 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 360102000697 dimer interface [polypeptide binding]; other site 360102000698 ssDNA binding site [nucleotide binding]; other site 360102000699 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360102000700 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 360102000701 Predicted esterase [General function prediction only]; Region: COG0400 360102000702 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 360102000703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102000704 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102000705 DNA-binding interface [nucleotide binding]; DNA binding site 360102000706 Integrase core domain; Region: rve; pfam00665 360102000707 transposase/IS protein; Provisional; Region: PRK09183 360102000708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102000709 Walker A motif; other site 360102000710 ATP binding site [chemical binding]; other site 360102000711 Walker B motif; other site 360102000712 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 360102000713 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 360102000714 acetylornithine deacetylase; Provisional; Region: PRK05111 360102000715 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 360102000716 metal binding site [ion binding]; metal-binding site 360102000717 putative dimer interface [polypeptide binding]; other site 360102000718 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 360102000719 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 360102000720 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 360102000721 nucleotide binding site [chemical binding]; other site 360102000722 N-acetyl-L-glutamate binding site [chemical binding]; other site 360102000723 argininosuccinate lyase; Provisional; Region: PRK04833 360102000724 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 360102000725 active sites [active] 360102000726 tetramer interface [polypeptide binding]; other site 360102000727 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 360102000728 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 360102000729 N-terminal plug; other site 360102000730 ligand-binding site [chemical binding]; other site 360102000731 Heme-binding protein A (HasA); Region: HasA; pfam06438 360102000732 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 360102000733 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 360102000734 Walker A/P-loop; other site 360102000735 ATP binding site [chemical binding]; other site 360102000736 Q-loop/lid; other site 360102000737 ABC transporter signature motif; other site 360102000738 Walker B; other site 360102000739 D-loop; other site 360102000740 H-loop/switch region; other site 360102000741 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 360102000742 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102000743 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102000744 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 360102000745 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 360102000746 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 360102000747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360102000748 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360102000749 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 360102000750 catalytic triad [active] 360102000751 dimer interface [polypeptide binding]; other site 360102000752 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 360102000753 GSH binding site [chemical binding]; other site 360102000754 catalytic residues [active] 360102000755 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 360102000756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102000757 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 360102000758 dimerization interface [polypeptide binding]; other site 360102000759 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 360102000760 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360102000761 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360102000762 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 360102000763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360102000764 hypothetical protein; Provisional; Region: PRK11056 360102000765 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 360102000766 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 360102000767 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 360102000768 N-terminal plug; other site 360102000769 ligand-binding site [chemical binding]; other site 360102000770 glutamate racemase; Provisional; Region: PRK00865 360102000771 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 360102000772 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 360102000773 putative ligand binding site [chemical binding]; other site 360102000774 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360102000775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102000776 Walker A/P-loop; other site 360102000777 ATP binding site [chemical binding]; other site 360102000778 Q-loop/lid; other site 360102000779 ABC transporter signature motif; other site 360102000780 Walker B; other site 360102000781 D-loop; other site 360102000782 H-loop/switch region; other site 360102000783 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102000784 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102000785 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102000786 TM-ABC transporter signature motif; other site 360102000787 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102000788 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102000789 TM-ABC transporter signature motif; other site 360102000790 transcriptional regulator HdfR; Provisional; Region: PRK03601 360102000791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102000792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 360102000793 dimerization interface [polypeptide binding]; other site 360102000794 hypothetical protein; Provisional; Region: PRK11027 360102000795 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 360102000796 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 360102000797 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 360102000798 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 360102000799 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 360102000800 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 360102000801 PYR/PP interface [polypeptide binding]; other site 360102000802 dimer interface [polypeptide binding]; other site 360102000803 TPP binding site [chemical binding]; other site 360102000804 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 360102000805 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 360102000806 TPP-binding site [chemical binding]; other site 360102000807 dimer interface [polypeptide binding]; other site 360102000808 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 360102000809 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 360102000810 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 360102000811 homodimer interface [polypeptide binding]; other site 360102000812 substrate-cofactor binding pocket; other site 360102000813 catalytic residue [active] 360102000814 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 360102000815 threonine dehydratase; Reviewed; Region: PRK09224 360102000816 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 360102000817 tetramer interface [polypeptide binding]; other site 360102000818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102000819 catalytic residue [active] 360102000820 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 360102000821 putative Ile/Val binding site [chemical binding]; other site 360102000822 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 360102000823 putative Ile/Val binding site [chemical binding]; other site 360102000824 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 360102000825 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 360102000826 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 360102000827 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 360102000828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102000829 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 360102000830 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 360102000831 putative dimerization interface [polypeptide binding]; other site 360102000832 ketol-acid reductoisomerase; Validated; Region: PRK05225 360102000833 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 360102000834 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 360102000835 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 360102000836 S-type Pyocin; Region: Pyocin_S; pfam06958 360102000837 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 360102000838 active site 360102000839 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 360102000840 cystathionine beta-lyase; Provisional; Region: PRK09028 360102000841 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 360102000842 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102000843 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 360102000844 Fimbrial protein; Region: Fimbrial; cl01416 360102000845 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 360102000846 PapC N-terminal domain; Region: PapC_N; pfam13954 360102000847 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102000848 PapC C-terminal domain; Region: PapC_C; pfam13953 360102000849 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 360102000850 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102000851 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 360102000852 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 360102000853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102000854 MULE transposase domain; Region: MULE; pfam10551 360102000855 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 360102000856 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 360102000857 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 360102000858 Part of AAA domain; Region: AAA_19; pfam13245 360102000859 Family description; Region: UvrD_C_2; pfam13538 360102000860 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 360102000861 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 360102000862 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 360102000863 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 360102000864 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360102000865 ATP binding site [chemical binding]; other site 360102000866 Mg++ binding site [ion binding]; other site 360102000867 motif III; other site 360102000868 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102000869 nucleotide binding region [chemical binding]; other site 360102000870 ATP-binding site [chemical binding]; other site 360102000871 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360102000872 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 360102000873 catalytic residues [active] 360102000874 transcription termination factor Rho; Provisional; Region: rho; PRK09376 360102000875 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 360102000876 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 360102000877 RNA binding site [nucleotide binding]; other site 360102000878 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 360102000879 multimer interface [polypeptide binding]; other site 360102000880 Walker A motif; other site 360102000881 ATP binding site [chemical binding]; other site 360102000882 Walker B motif; other site 360102000883 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 360102000884 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 360102000885 Mg++ binding site [ion binding]; other site 360102000886 putative catalytic motif [active] 360102000887 substrate binding site [chemical binding]; other site 360102000888 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 360102000889 Chain length determinant protein; Region: Wzz; cl15801 360102000890 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 360102000891 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 360102000892 active site 360102000893 homodimer interface [polypeptide binding]; other site 360102000894 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 360102000895 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 360102000896 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 360102000897 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 360102000898 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 360102000899 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 360102000900 NAD binding site [chemical binding]; other site 360102000901 substrate binding site [chemical binding]; other site 360102000902 homodimer interface [polypeptide binding]; other site 360102000903 active site 360102000904 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 360102000905 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 360102000906 substrate binding site; other site 360102000907 tetramer interface; other site 360102000908 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360102000909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360102000910 Coenzyme A binding pocket [chemical binding]; other site 360102000911 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 360102000912 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 360102000913 inhibitor-cofactor binding pocket; inhibition site 360102000914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102000915 catalytic residue [active] 360102000916 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 360102000917 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 360102000918 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 360102000919 putative common antigen polymerase; Provisional; Region: PRK02975 360102000920 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 360102000921 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 360102000922 putative transport protein YifK; Provisional; Region: PRK10746 360102000923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102000924 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102000925 DNA-binding interface [nucleotide binding]; DNA binding site 360102000926 Integrase core domain; Region: rve; pfam00665 360102000927 transposase/IS protein; Provisional; Region: PRK09183 360102000928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102000929 Walker A motif; other site 360102000930 ATP binding site [chemical binding]; other site 360102000931 Walker B motif; other site 360102000932 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 360102000933 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102000934 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 360102000935 HemY protein N-terminus; Region: HemY_N; pfam07219 360102000936 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 360102000937 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 360102000938 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 360102000939 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 360102000940 active site 360102000941 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 360102000942 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 360102000943 domain interfaces; other site 360102000944 active site 360102000945 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 360102000946 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 360102000947 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 360102000948 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 360102000949 putative iron binding site [ion binding]; other site 360102000950 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 360102000951 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 360102000952 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 360102000953 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 360102000954 hypothetical protein; Provisional; Region: PRK10963 360102000955 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 360102000956 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360102000957 active site 360102000958 DNA binding site [nucleotide binding] 360102000959 Int/Topo IB signature motif; other site 360102000960 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 360102000961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102000962 motif II; other site 360102000963 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 360102000964 Part of AAA domain; Region: AAA_19; pfam13245 360102000965 Family description; Region: UvrD_C_2; pfam13538 360102000966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360102000967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360102000968 Uncharacterized conserved protein [Function unknown]; Region: COG5441 360102000969 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 360102000970 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 360102000971 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 360102000972 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 360102000973 Cl binding site [ion binding]; other site 360102000974 oligomer interface [polypeptide binding]; other site 360102000975 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 360102000976 EamA-like transporter family; Region: EamA; cl17759 360102000977 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 360102000978 CoenzymeA binding site [chemical binding]; other site 360102000979 subunit interaction site [polypeptide binding]; other site 360102000980 PHB binding site; other site 360102000981 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 360102000982 substrate binding site [chemical binding]; other site 360102000983 dimerization interface [polypeptide binding]; other site 360102000984 active site 360102000985 calcium binding site [ion binding]; other site 360102000986 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 360102000987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360102000988 ATP binding site [chemical binding]; other site 360102000989 putative Mg++ binding site [ion binding]; other site 360102000990 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102000991 nucleotide binding region [chemical binding]; other site 360102000992 ATP-binding site [chemical binding]; other site 360102000993 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 360102000994 HRDC domain; Region: HRDC; pfam00570 360102000995 threonine efflux system; Provisional; Region: PRK10229 360102000996 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 360102000997 lysophospholipase L2; Provisional; Region: PRK10749 360102000998 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 360102000999 putative hydrolase; Provisional; Region: PRK10976 360102001000 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102001001 active site 360102001002 motif I; other site 360102001003 motif II; other site 360102001004 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 360102001005 Viral enhancin protein; Region: Enhancin; pfam03272 360102001006 Viral enhancin protein; Region: Enhancin; pfam03272 360102001007 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 360102001008 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 360102001009 active site 360102001010 catalytic site [active] 360102001011 metal binding site [ion binding]; metal-binding site 360102001012 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 360102001013 hydroxyglutarate oxidase; Provisional; Region: PRK11728 360102001014 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 360102001015 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 360102001016 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 360102001017 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 360102001018 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 360102001019 Cysteine-rich domain; Region: CCG; pfam02754 360102001020 Cysteine-rich domain; Region: CCG; pfam02754 360102001021 hypothetical protein; Provisional; Region: PRK11615 360102001022 hypothetical protein; Provisional; Region: PRK11212 360102001023 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 360102001024 CPxP motif; other site 360102001025 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 360102001026 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 360102001027 metal-binding site [ion binding] 360102001028 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360102001029 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 360102001030 Predicted membrane protein [Function unknown]; Region: COG3714 360102001031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4517 360102001032 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 360102001033 hypothetical protein; Provisional; Region: PRK10910 360102001034 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 360102001035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102001036 S-adenosylmethionine binding site [chemical binding]; other site 360102001037 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 360102001038 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 360102001039 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 360102001040 P loop; other site 360102001041 GTP binding site [chemical binding]; other site 360102001042 cell division protein FtsE; Provisional; Region: PRK10908 360102001043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102001044 Walker A/P-loop; other site 360102001045 ATP binding site [chemical binding]; other site 360102001046 Q-loop/lid; other site 360102001047 ABC transporter signature motif; other site 360102001048 Walker B; other site 360102001049 D-loop; other site 360102001050 H-loop/switch region; other site 360102001051 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 360102001052 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 360102001053 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 360102001054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360102001055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360102001056 DNA binding residues [nucleotide binding] 360102001057 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102001058 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 360102001059 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 360102001060 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 360102001061 dimerization interface [polypeptide binding]; other site 360102001062 ligand binding site [chemical binding]; other site 360102001063 transposase/IS protein; Provisional; Region: PRK09183 360102001064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102001065 Walker A motif; other site 360102001066 ATP binding site [chemical binding]; other site 360102001067 Walker B motif; other site 360102001068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102001069 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102001070 DNA-binding interface [nucleotide binding]; DNA binding site 360102001071 Integrase core domain; Region: rve; pfam00665 360102001072 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102001073 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 360102001074 TM-ABC transporter signature motif; other site 360102001075 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 360102001076 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 360102001077 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 360102001078 TM-ABC transporter signature motif; other site 360102001079 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 360102001080 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 360102001081 Walker A/P-loop; other site 360102001082 ATP binding site [chemical binding]; other site 360102001083 Q-loop/lid; other site 360102001084 ABC transporter signature motif; other site 360102001085 Walker B; other site 360102001086 D-loop; other site 360102001087 H-loop/switch region; other site 360102001088 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 360102001089 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 360102001090 Walker A/P-loop; other site 360102001091 ATP binding site [chemical binding]; other site 360102001092 Q-loop/lid; other site 360102001093 ABC transporter signature motif; other site 360102001094 Walker B; other site 360102001095 D-loop; other site 360102001096 H-loop/switch region; other site 360102001097 putative fimbrial protein TcfA; Provisional; Region: PRK15308 360102001098 putative fimbrial protein TcfA; Provisional; Region: PRK15308 360102001099 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102001100 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360102001101 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 360102001102 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 360102001103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102001104 dimer interface [polypeptide binding]; other site 360102001105 conserved gate region; other site 360102001106 putative PBP binding loops; other site 360102001107 ABC-ATPase subunit interface; other site 360102001108 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360102001109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102001110 dimer interface [polypeptide binding]; other site 360102001111 conserved gate region; other site 360102001112 putative PBP binding loops; other site 360102001113 ABC-ATPase subunit interface; other site 360102001114 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 360102001115 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 360102001116 Walker A/P-loop; other site 360102001117 ATP binding site [chemical binding]; other site 360102001118 Q-loop/lid; other site 360102001119 ABC transporter signature motif; other site 360102001120 Walker B; other site 360102001121 D-loop; other site 360102001122 H-loop/switch region; other site 360102001123 TOBE domain; Region: TOBE_2; pfam08402 360102001124 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 360102001125 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 360102001126 putative active site [active] 360102001127 catalytic site [active] 360102001128 putative metal binding site [ion binding]; other site 360102001129 Predicted permeases [General function prediction only]; Region: COG0679 360102001130 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 360102001131 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 360102001132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102001133 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 360102001134 putative dimerization interface [polypeptide binding]; other site 360102001135 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 360102001136 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 360102001137 THF binding site; other site 360102001138 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 360102001139 substrate binding site [chemical binding]; other site 360102001140 THF binding site; other site 360102001141 zinc-binding site [ion binding]; other site 360102001142 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 360102001143 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 360102001144 uridine phosphorylase; Provisional; Region: PRK11178 360102001145 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 360102001146 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 360102001147 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 360102001148 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 360102001149 Carbon starvation protein CstA; Region: CstA; pfam02554 360102001150 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 360102001151 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360102001152 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 360102001153 RmuC family; Region: RmuC; pfam02646 360102001154 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 360102001155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102001156 S-adenosylmethionine binding site [chemical binding]; other site 360102001157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 360102001158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 360102001159 SCP-2 sterol transfer family; Region: SCP2; pfam02036 360102001160 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 360102001161 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 360102001162 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 360102001163 sec-independent translocase; Provisional; Region: PRK01770 360102001164 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 360102001165 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 360102001166 active site 360102001167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102001168 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102001169 DNA-binding interface [nucleotide binding]; DNA binding site 360102001170 Integrase core domain; Region: rve; pfam00665 360102001171 transposase/IS protein; Provisional; Region: PRK09183 360102001172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102001173 Walker A motif; other site 360102001174 ATP binding site [chemical binding]; other site 360102001175 Walker B motif; other site 360102001176 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 360102001177 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 360102001178 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 360102001179 UbiA prenyltransferase family; Region: UbiA; pfam01040 360102001180 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 360102001181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102001182 Walker A motif; other site 360102001183 ATP binding site [chemical binding]; other site 360102001184 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 360102001185 Walker B motif; other site 360102001186 arginine finger; other site 360102001187 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 360102001188 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 360102001189 active site 360102001190 HslU subunit interaction site [polypeptide binding]; other site 360102001191 cell division protein FtsN; Provisional; Region: PRK12757 360102001192 Sporulation related domain; Region: SPOR; cl10051 360102001193 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102001194 DNA binding site [nucleotide binding] 360102001195 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 360102001196 domain linker motif; other site 360102001197 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 360102001198 dimerization interface [polypeptide binding]; other site 360102001199 ligand binding site [chemical binding]; other site 360102001200 primosome assembly protein PriA; Validated; Region: PRK05580 360102001201 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360102001202 ATP binding site [chemical binding]; other site 360102001203 putative Mg++ binding site [ion binding]; other site 360102001204 helicase superfamily c-terminal domain; Region: HELICc; smart00490 360102001205 ATP-binding site [chemical binding]; other site 360102001206 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 360102001207 Predicted membrane protein [Function unknown]; Region: COG4682 360102001208 yiaA/B two helix domain; Region: YiaAB; pfam05360 360102001209 yiaA/B two helix domain; Region: YiaAB; pfam05360 360102001210 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 360102001211 dimerization interface [polypeptide binding]; other site 360102001212 DNA binding site [nucleotide binding] 360102001213 corepressor binding sites; other site 360102001214 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 360102001215 homodimer interface [polypeptide binding]; other site 360102001216 substrate-cofactor binding pocket; other site 360102001217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102001218 catalytic residue [active] 360102001219 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360102001220 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 360102001221 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 360102001222 putative catalytic residues [active] 360102001223 putative nucleotide binding site [chemical binding]; other site 360102001224 putative aspartate binding site [chemical binding]; other site 360102001225 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 360102001226 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 360102001227 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 360102001228 FAD binding site [chemical binding]; other site 360102001229 putative transposase OrfB; Reviewed; Region: PHA02517 360102001230 HTH-like domain; Region: HTH_21; pfam13276 360102001231 Integrase core domain; Region: rve; pfam00665 360102001232 Integrase core domain; Region: rve_2; pfam13333 360102001233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 360102001234 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102001235 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102001236 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 360102001237 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 360102001238 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 360102001239 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 360102001240 N-terminal plug; other site 360102001241 ligand-binding site [chemical binding]; other site 360102001242 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 360102001243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360102001244 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 360102001245 IucA / IucC family; Region: IucA_IucC; pfam04183 360102001246 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 360102001247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 360102001248 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 360102001249 IucA / IucC family; Region: IucA_IucC; pfam04183 360102001250 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 360102001251 IucA / IucC family; Region: IucA_IucC; pfam04183 360102001252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102001253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360102001254 putative substrate translocation pore; other site 360102001255 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 360102001256 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 360102001257 putative active site [active] 360102001258 Predicted peptidase [General function prediction only]; Region: COG4099 360102001259 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 360102001260 Autoinducer binding domain; Region: Autoind_bind; pfam03472 360102001261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102001262 DNA binding residues [nucleotide binding] 360102001263 dimerization interface [polypeptide binding]; other site 360102001264 Autoinducer synthetase; Region: Autoind_synth; pfam00765 360102001265 CAAX protease self-immunity; Region: Abi; pfam02517 360102001266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 360102001267 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 360102001268 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 360102001269 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 360102001270 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 360102001271 Protein of unknown function (DUF877); Region: DUF877; pfam05943 360102001272 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 360102001273 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 360102001274 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 360102001275 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 360102001276 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360102001277 ligand binding site [chemical binding]; other site 360102001278 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 360102001279 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 360102001280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102001281 Walker A motif; other site 360102001282 ATP binding site [chemical binding]; other site 360102001283 Walker B motif; other site 360102001284 arginine finger; other site 360102001285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102001286 Walker A motif; other site 360102001287 ATP binding site [chemical binding]; other site 360102001288 Walker B motif; other site 360102001289 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 360102001290 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 360102001291 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 360102001292 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 360102001293 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 360102001294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 360102001295 Peptidase family M23; Region: Peptidase_M23; pfam01551 360102001296 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 360102001297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 360102001298 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 360102001299 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 360102001300 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 360102001301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 360102001302 Peptidase family M23; Region: Peptidase_M23; pfam01551 360102001303 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 360102001304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 360102001305 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 360102001306 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 360102001307 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 360102001308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 360102001309 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360102001310 DNA binding site [nucleotide binding] 360102001311 active site 360102001312 Int/Topo IB signature motif; other site 360102001313 ornithine decarboxylase; Provisional; Region: PRK13578 360102001314 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 360102001315 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 360102001316 homodimer interface [polypeptide binding]; other site 360102001317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102001318 catalytic residue [active] 360102001319 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 360102001320 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 360102001321 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 360102001322 putative ligand binding site [chemical binding]; other site 360102001323 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360102001324 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102001325 Walker A/P-loop; other site 360102001326 ATP binding site [chemical binding]; other site 360102001327 Q-loop/lid; other site 360102001328 ABC transporter signature motif; other site 360102001329 Walker B; other site 360102001330 D-loop; other site 360102001331 H-loop/switch region; other site 360102001332 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102001333 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102001334 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102001335 TM-ABC transporter signature motif; other site 360102001336 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 360102001337 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 360102001338 N-terminal plug; other site 360102001339 ligand-binding site [chemical binding]; other site 360102001340 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 360102001341 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 360102001342 putative ligand binding residues [chemical binding]; other site 360102001343 murein transglycosylase C; Provisional; Region: mltC; PRK11671 360102001344 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 360102001345 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 360102001346 N-acetyl-D-glucosamine binding site [chemical binding]; other site 360102001347 catalytic residue [active] 360102001348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924 360102001349 adenine DNA glycosylase; Provisional; Region: PRK10880 360102001350 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 360102001351 minor groove reading motif; other site 360102001352 helix-hairpin-helix signature motif; other site 360102001353 substrate binding pocket [chemical binding]; other site 360102001354 active site 360102001355 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 360102001356 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 360102001357 DNA binding and oxoG recognition site [nucleotide binding] 360102001358 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 360102001359 hypothetical protein; Provisional; Region: PRK11702 360102001360 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 360102001361 glutaminase; Provisional; Region: PRK00971 360102001362 hypothetical protein; Provisional; Region: PRK10626 360102001363 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 360102001364 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 360102001365 hypothetical protein; Provisional; Region: PRK10626 360102001366 Peptidase C80 family; Region: Peptidase_C80; pfam11713 360102001367 Peptidase C80 family; Region: Peptidase_C80; pfam11713 360102001368 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 360102001369 HemN family oxidoreductase; Provisional; Region: PRK05660 360102001370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102001371 FeS/SAM binding site; other site 360102001372 HemN C-terminal domain; Region: HemN_C; pfam06969 360102001373 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 360102001374 active site 360102001375 dimerization interface [polypeptide binding]; other site 360102001376 hypothetical protein; Validated; Region: PRK05090 360102001377 YGGT family; Region: YGGT; pfam02325 360102001378 Predicted integral membrane protein [Function unknown]; Region: COG0762 360102001379 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 360102001380 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 360102001381 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 360102001382 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360102001383 catalytic residue [active] 360102001384 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 360102001385 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 360102001386 Walker A motif; other site 360102001387 ATP binding site [chemical binding]; other site 360102001388 Walker B motif; other site 360102001389 agmatine deiminase; Provisional; Region: PRK13551 360102001390 agmatine deiminase; Region: agmatine_aguA; TIGR03380 360102001391 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 360102001392 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 360102001393 putative active site; other site 360102001394 catalytic triad [active] 360102001395 putative dimer interface [polypeptide binding]; other site 360102001396 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 360102001397 hypothetical protein; Validated; Region: PRK00228 360102001398 glutathione synthetase; Provisional; Region: PRK05246 360102001399 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 360102001400 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 360102001401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 360102001402 RNA methyltransferase, RsmE family; Region: TIGR00046 360102001403 DNA-specific endonuclease I; Provisional; Region: PRK15137 360102001404 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 360102001405 hypothetical protein; Provisional; Region: PRK04860 360102001406 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 360102001407 S-adenosylmethionine synthetase; Validated; Region: PRK05250 360102001408 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 360102001409 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 360102001410 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 360102001411 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 360102001412 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 360102001413 dimer interface [polypeptide binding]; other site 360102001414 active site 360102001415 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360102001416 catalytic residues [active] 360102001417 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 360102001418 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102001419 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 360102001420 [2Fe-2S] cluster binding site [ion binding]; other site 360102001421 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 360102001422 transketolase; Reviewed; Region: PRK12753 360102001423 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 360102001424 TPP-binding site [chemical binding]; other site 360102001425 dimer interface [polypeptide binding]; other site 360102001426 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 360102001427 PYR/PP interface [polypeptide binding]; other site 360102001428 dimer interface [polypeptide binding]; other site 360102001429 TPP binding site [chemical binding]; other site 360102001430 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 360102001431 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102001432 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 360102001433 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 360102001434 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 360102001435 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 360102001436 Phosphoglycerate kinase; Region: PGK; pfam00162 360102001437 substrate binding site [chemical binding]; other site 360102001438 hinge regions; other site 360102001439 ADP binding site [chemical binding]; other site 360102001440 catalytic site [active] 360102001441 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 360102001442 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 360102001443 active site 360102001444 intersubunit interface [polypeptide binding]; other site 360102001445 zinc binding site [ion binding]; other site 360102001446 Na+ binding site [ion binding]; other site 360102001447 mechanosensitive channel MscS; Provisional; Region: PRK10334 360102001448 Conserved TM helix; Region: TM_helix; pfam05552 360102001449 Mechanosensitive ion channel; Region: MS_channel; pfam00924 360102001450 LysE type translocator; Region: LysE; cl00565 360102001451 transposase/IS protein; Provisional; Region: PRK09183 360102001452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102001453 Walker A motif; other site 360102001454 ATP binding site [chemical binding]; other site 360102001455 Walker B motif; other site 360102001456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102001457 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102001458 DNA-binding interface [nucleotide binding]; DNA binding site 360102001459 Integrase core domain; Region: rve; pfam00665 360102001460 LysE type translocator; Region: LysE; cl00565 360102001461 Uncharacterized conserved protein [Function unknown]; Region: COG2968 360102001462 oxidative stress defense protein; Provisional; Region: PRK11087 360102001463 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 360102001464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102001465 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 360102001466 putative dimerization interface [polypeptide binding]; other site 360102001467 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 360102001468 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360102001469 active site 360102001470 dimer interface [polypeptide binding]; other site 360102001471 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 360102001472 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 360102001473 ligand binding site [chemical binding]; other site 360102001474 NAD binding site [chemical binding]; other site 360102001475 tetramer interface [polypeptide binding]; other site 360102001476 catalytic site [active] 360102001477 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 360102001478 L-serine binding site [chemical binding]; other site 360102001479 ACT domain interface; other site 360102001480 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 360102001481 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 360102001482 Z-ring-associated protein; Provisional; Region: PRK10972 360102001483 hypothetical protein; Reviewed; Region: PRK01736 360102001484 proline aminopeptidase P II; Provisional; Region: PRK10879 360102001485 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 360102001486 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 360102001487 active site 360102001488 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 360102001489 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 360102001490 oxidoreductase; Provisional; Region: PRK08013 360102001491 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 360102001492 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 360102001493 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 360102001494 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 360102001495 lipoyl attachment site [posttranslational modification]; other site 360102001496 glycine dehydrogenase; Provisional; Region: PRK05367 360102001497 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 360102001498 tetramer interface [polypeptide binding]; other site 360102001499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102001500 catalytic residue [active] 360102001501 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 360102001502 tetramer interface [polypeptide binding]; other site 360102001503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102001504 catalytic residue [active] 360102001505 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 360102001506 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 360102001507 YadA-like C-terminal region; Region: YadA; pfam03895 360102001508 hemolysin; Provisional; Region: PRK15087 360102001509 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 360102001510 Predicted small integral membrane protein [Function unknown]; Region: COG5472 360102001511 putative global regulator; Reviewed; Region: PRK09559 360102001512 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 360102001513 hypothetical protein; Provisional; Region: PRK10878 360102001514 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 360102001515 DNA-binding response regulator CreB; Provisional; Region: PRK11083 360102001516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102001517 active site 360102001518 phosphorylation site [posttranslational modification] 360102001519 intermolecular recognition site; other site 360102001520 dimerization interface [polypeptide binding]; other site 360102001521 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102001522 DNA binding site [nucleotide binding] 360102001523 sensory histidine kinase CreC; Provisional; Region: PRK11100 360102001524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102001525 dimer interface [polypeptide binding]; other site 360102001526 phosphorylation site [posttranslational modification] 360102001527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102001528 ATP binding site [chemical binding]; other site 360102001529 Mg2+ binding site [ion binding]; other site 360102001530 G-X-G motif; other site 360102001531 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 360102001532 flavodoxin FldB; Provisional; Region: PRK12359 360102001533 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 360102001534 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 360102001535 active site 360102001536 Int/Topo IB signature motif; other site 360102001537 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 360102001538 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 360102001539 dimerization domain [polypeptide binding]; other site 360102001540 dimer interface [polypeptide binding]; other site 360102001541 catalytic residues [active] 360102001542 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 360102001543 DHH family; Region: DHH; pfam01368 360102001544 DHHA1 domain; Region: DHHA1; pfam02272 360102001545 peptide chain release factor 2; Provisional; Region: PRK08787 360102001546 This domain is found in peptide chain release factors; Region: PCRF; smart00937 360102001547 RF-1 domain; Region: RF-1; pfam00472 360102001548 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 360102001549 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 360102001550 dimer interface [polypeptide binding]; other site 360102001551 putative anticodon binding site; other site 360102001552 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 360102001553 motif 1; other site 360102001554 active site 360102001555 motif 2; other site 360102001556 motif 3; other site 360102001557 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 360102001558 transposase/IS protein; Provisional; Region: PRK09183 360102001559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102001560 Walker A motif; other site 360102001561 ATP binding site [chemical binding]; other site 360102001562 Walker B motif; other site 360102001563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102001564 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102001565 DNA-binding interface [nucleotide binding]; DNA binding site 360102001566 Integrase core domain; Region: rve; pfam00665 360102001567 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 360102001568 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 360102001569 active site 360102001570 Int/Topo IB signature motif; other site 360102001571 Ash protein family; Region: Phage_ASH; pfam10554 360102001572 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 360102001573 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360102001574 non-specific DNA binding site [nucleotide binding]; other site 360102001575 salt bridge; other site 360102001576 sequence-specific DNA binding site [nucleotide binding]; other site 360102001577 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 360102001578 peptide binding site [polypeptide binding]; other site 360102001579 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 360102001580 toxin interface [polypeptide binding]; other site 360102001581 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 360102001582 Zn binding site [ion binding]; other site 360102001583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360102001584 non-specific DNA binding site [nucleotide binding]; other site 360102001585 salt bridge; other site 360102001586 sequence-specific DNA binding site [nucleotide binding]; other site 360102001587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 360102001588 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 360102001589 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 360102001590 D5 N terminal like; Region: D5_N; smart00885 360102001591 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 360102001592 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 360102001593 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 360102001594 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 360102001595 Fic family protein [Function unknown]; Region: COG3177 360102001596 Fic/DOC family; Region: Fic; pfam02661 360102001597 PAAR motif; Region: PAAR_motif; pfam05488 360102001598 Pyocin large subunit [General function prediction only]; Region: COG5529 360102001599 S-type Pyocin; Region: Pyocin_S; pfam06958 360102001600 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 360102001601 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 360102001602 PAAR motif; Region: PAAR_motif; pfam05488 360102001603 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 360102001604 Predicted transcriptional regulators [Transcription]; Region: COG1695 360102001605 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 360102001606 hypothetical protein; Provisional; Region: PRK11479 360102001607 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 360102001608 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 360102001609 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 360102001610 putative ligand binding site [chemical binding]; other site 360102001611 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102001612 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102001613 TM-ABC transporter signature motif; other site 360102001614 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360102001615 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102001616 Walker A/P-loop; other site 360102001617 ATP binding site [chemical binding]; other site 360102001618 Q-loop/lid; other site 360102001619 ABC transporter signature motif; other site 360102001620 Walker B; other site 360102001621 D-loop; other site 360102001622 H-loop/switch region; other site 360102001623 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102001624 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 360102001625 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 360102001626 Walker A/P-loop; other site 360102001627 ATP binding site [chemical binding]; other site 360102001628 Q-loop/lid; other site 360102001629 ABC transporter signature motif; other site 360102001630 Walker B; other site 360102001631 D-loop; other site 360102001632 H-loop/switch region; other site 360102001633 TOBE domain; Region: TOBE_2; pfam08402 360102001634 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 360102001635 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 360102001636 DAK2 domain; Region: Dak2; cl03685 360102001637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102001638 dimer interface [polypeptide binding]; other site 360102001639 conserved gate region; other site 360102001640 ABC-ATPase subunit interface; other site 360102001641 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360102001642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102001643 dimer interface [polypeptide binding]; other site 360102001644 conserved gate region; other site 360102001645 putative PBP binding loops; other site 360102001646 ABC-ATPase subunit interface; other site 360102001647 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 360102001648 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 360102001649 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 360102001650 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 360102001651 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 360102001652 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360102001653 active site turn [active] 360102001654 phosphorylation site [posttranslational modification] 360102001655 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 360102001656 trimer interface; other site 360102001657 sugar binding site [chemical binding]; other site 360102001658 lac repressor; Reviewed; Region: lacI; PRK09526 360102001659 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102001660 DNA binding site [nucleotide binding] 360102001661 domain linker motif; other site 360102001662 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 360102001663 ligand binding site [chemical binding]; other site 360102001664 dimerization interface (open form) [polypeptide binding]; other site 360102001665 dimerization interface (closed form) [polypeptide binding]; other site 360102001666 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 360102001667 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 360102001668 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 360102001669 putative active site [active] 360102001670 putative catalytic site [active] 360102001671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102001672 D-galactonate transporter; Region: 2A0114; TIGR00893 360102001673 putative substrate translocation pore; other site 360102001674 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360102001675 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102001676 DNA binding site [nucleotide binding] 360102001677 domain linker motif; other site 360102001678 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 360102001679 dimerization interface [polypeptide binding]; other site 360102001680 ligand binding site [chemical binding]; other site 360102001681 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 360102001682 DJ-1 family protein; Region: not_thiJ; TIGR01383 360102001683 conserved cys residue [active] 360102001684 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 360102001685 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 360102001686 intersubunit interface [polypeptide binding]; other site 360102001687 active site 360102001688 zinc binding site [ion binding]; other site 360102001689 Na+ binding site [ion binding]; other site 360102001690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289 360102001691 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 360102001692 Sulfatase; Region: Sulfatase; pfam00884 360102001693 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 360102001694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102001695 FeS/SAM binding site; other site 360102001696 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 360102001697 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 360102001698 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481 360102001699 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 360102001700 NADP binding site [chemical binding]; other site 360102001701 homodimer interface [polypeptide binding]; other site 360102001702 active site 360102001703 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 360102001704 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 360102001705 active site 360102001706 dimer interface [polypeptide binding]; other site 360102001707 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 360102001708 active pocket/dimerization site; other site 360102001709 active site 360102001710 phosphorylation site [posttranslational modification] 360102001711 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 360102001712 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 360102001713 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 360102001714 active site 360102001715 phosphorylation site [posttranslational modification] 360102001716 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 360102001717 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 360102001718 dimer interface [polypeptide binding]; other site 360102001719 active site 360102001720 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 360102001721 putative active site [active] 360102001722 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 360102001723 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 360102001724 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 360102001725 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 360102001726 Sulfatase; Region: Sulfatase; cl17466 360102001727 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 360102001728 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102001729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102001730 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102001731 DNA-binding interface [nucleotide binding]; DNA binding site 360102001732 Integrase core domain; Region: rve; pfam00665 360102001733 transposase/IS protein; Provisional; Region: PRK09183 360102001734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102001735 Walker A motif; other site 360102001736 ATP binding site [chemical binding]; other site 360102001737 Walker B motif; other site 360102001738 Transposase IS200 like; Region: Y1_Tnp; cl00848 360102001739 Lyase, N terminal; Region: Lyase_N; pfam09092 360102001740 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 360102001741 substrate binding site [chemical binding]; other site 360102001742 catalytic residues [active] 360102001743 Autotransporter beta-domain; Region: Autotransporter; pfam03797 360102001744 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 360102001745 active site clefts [active] 360102001746 zinc binding site [ion binding]; other site 360102001747 dimer interface [polypeptide binding]; other site 360102001748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 360102001749 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 360102001750 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 360102001751 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 360102001752 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 360102001753 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 360102001754 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 360102001755 type II secretion system protein E; Region: type_II_gspE; TIGR02533 360102001756 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 360102001757 Walker A motif; other site 360102001758 ATP binding site [chemical binding]; other site 360102001759 Walker B motif; other site 360102001760 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 360102001761 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 360102001762 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 360102001763 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 360102001764 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 360102001765 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 360102001766 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 360102001767 type II secretion system protein I; Region: gspI; TIGR01707 360102001768 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 360102001769 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 360102001770 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 360102001771 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 360102001772 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 360102001773 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 360102001774 GspL periplasmic domain; Region: GspL_C; pfam12693 360102001775 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 360102001776 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 360102001777 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 360102001778 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 360102001779 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 360102001780 DNA binding site [nucleotide binding] 360102001781 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 360102001782 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 360102001783 dimer interface [polypeptide binding]; other site 360102001784 ligand binding site [chemical binding]; other site 360102001785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102001786 dimerization interface [polypeptide binding]; other site 360102001787 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360102001788 dimer interface [polypeptide binding]; other site 360102001789 putative CheW interface [polypeptide binding]; other site 360102001790 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 360102001791 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 360102001792 catalytic residues [active] 360102001793 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 360102001794 transcriptional activator TtdR; Provisional; Region: PRK09801 360102001795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102001796 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 360102001797 putative effector binding pocket; other site 360102001798 dimerization interface [polypeptide binding]; other site 360102001799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102001800 putative substrate translocation pore; other site 360102001801 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360102001802 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 360102001803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102001804 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360102001805 dimerization interface [polypeptide binding]; other site 360102001806 diaminopimelate decarboxylase; Provisional; Region: PRK11165 360102001807 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 360102001808 active site 360102001809 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360102001810 substrate binding site [chemical binding]; other site 360102001811 catalytic residues [active] 360102001812 dimer interface [polypeptide binding]; other site 360102001813 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 360102001814 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102001815 DNA binding site [nucleotide binding] 360102001816 domain linker motif; other site 360102001817 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 360102001818 dimerization interface (closed form) [polypeptide binding]; other site 360102001819 ligand binding site [chemical binding]; other site 360102001820 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 360102001821 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 360102001822 molybdopterin cofactor binding site [chemical binding]; other site 360102001823 substrate binding site [chemical binding]; other site 360102001824 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 360102001825 molybdopterin cofactor binding site; other site 360102001826 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 360102001827 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 360102001828 putative acyl-acceptor binding pocket; other site 360102001829 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 360102001830 acyl-activating enzyme (AAE) consensus motif; other site 360102001831 putative AMP binding site [chemical binding]; other site 360102001832 lysophospholipid transporter LplT; Provisional; Region: PRK11195 360102001833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102001834 putative substrate translocation pore; other site 360102001835 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 360102001836 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360102001837 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360102001838 active site 360102001839 catalytic tetrad [active] 360102001840 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 360102001841 putative DNA-binding cleft [nucleotide binding]; other site 360102001842 putative DNA clevage site; other site 360102001843 molecular lever; other site 360102001844 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 360102001845 putative active site [active] 360102001846 Ap4A binding site [chemical binding]; other site 360102001847 nudix motif; other site 360102001848 putative metal binding site [ion binding]; other site 360102001849 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 360102001850 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 360102001851 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 360102001852 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 360102001853 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 360102001854 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 360102001855 thymidylate synthase; Reviewed; Region: thyA; PRK01827 360102001856 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 360102001857 dimerization interface [polypeptide binding]; other site 360102001858 active site 360102001859 hypothetical protein; Provisional; Region: PRK10506 360102001860 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 360102001861 hypothetical protein; Provisional; Region: PRK10557 360102001862 Protein of unknown function (DUF2509); Region: DUF2509; pfam10713 360102001863 hypothetical protein; Provisional; Region: PRK10332 360102001864 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 360102001865 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 360102001866 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 360102001867 protease3; Provisional; Region: PRK15101 360102001868 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 360102001869 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 360102001870 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 360102001871 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 360102001872 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 360102001873 AAA domain; Region: AAA_30; pfam13604 360102001874 Family description; Region: UvrD_C_2; pfam13538 360102001875 N-acetylglutamate synthase; Validated; Region: PRK05279 360102001876 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 360102001877 putative feedback inhibition sensing region; other site 360102001878 putative nucleotide binding site [chemical binding]; other site 360102001879 putative substrate binding site [chemical binding]; other site 360102001880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360102001881 Coenzyme A binding pocket [chemical binding]; other site 360102001882 AMIN domain; Region: AMIN; pfam11741 360102001883 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 360102001884 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 360102001885 active site 360102001886 metal binding site [ion binding]; metal-binding site 360102001887 murein transglycosylase A; Provisional; Region: mltA; PRK11162 360102001888 MltA specific insert domain; Region: MltA; smart00925 360102001889 3D domain; Region: 3D; pfam06725 360102001890 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 360102001891 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 360102001892 putative ATP binding site [chemical binding]; other site 360102001893 putative substrate interface [chemical binding]; other site 360102001894 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 360102001895 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 360102001896 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 360102001897 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102001898 catalytic residue [active] 360102001899 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 360102001900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102001901 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 360102001902 dimerization interface [polypeptide binding]; other site 360102001903 substrate binding pocket [chemical binding]; other site 360102001904 hypothetical protein; Provisional; Region: PRK10873 360102001905 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 360102001906 FtsJ-like methyltransferase; Region: FtsJ; cl17430 360102001907 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 360102001908 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102001909 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102001910 DNA-binding interface [nucleotide binding]; DNA binding site 360102001911 Integrase core domain; Region: rve; pfam00665 360102001912 transposase/IS protein; Provisional; Region: PRK09183 360102001913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102001914 Walker A motif; other site 360102001915 ATP binding site [chemical binding]; other site 360102001916 Walker B motif; other site 360102001917 flap endonuclease-like protein; Provisional; Region: PRK09482 360102001918 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 360102001919 active site 360102001920 metal binding site 1 [ion binding]; metal-binding site 360102001921 putative 5' ssDNA interaction site; other site 360102001922 metal binding site 3; metal-binding site 360102001923 metal binding site 2 [ion binding]; metal-binding site 360102001924 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 360102001925 putative DNA binding site [nucleotide binding]; other site 360102001926 putative metal binding site [ion binding]; other site 360102001927 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 360102001928 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 360102001929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 360102001930 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 360102001931 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 360102001932 SecY interacting protein Syd; Provisional; Region: PRK04968 360102001933 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102001934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 360102001935 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 360102001936 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 360102001937 probable active site [active] 360102001938 flavodoxin; Provisional; Region: PRK08105 360102001939 hypothetical protein; Provisional; Region: PRK13677 360102001940 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 360102001941 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 360102001942 trimer interface [polypeptide binding]; other site 360102001943 active site 360102001944 substrate binding site [chemical binding]; other site 360102001945 CoA binding site [chemical binding]; other site 360102001946 PII uridylyl-transferase; Provisional; Region: PRK05007 360102001947 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 360102001948 metal binding triad; other site 360102001949 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 360102001950 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 360102001951 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 360102001952 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 360102001953 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 360102001954 active site 360102001955 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 360102001956 rRNA interaction site [nucleotide binding]; other site 360102001957 S8 interaction site; other site 360102001958 putative laminin-1 binding site; other site 360102001959 elongation factor Ts; Provisional; Region: tsf; PRK09377 360102001960 UBA/TS-N domain; Region: UBA; pfam00627 360102001961 Elongation factor TS; Region: EF_TS; pfam00889 360102001962 Elongation factor TS; Region: EF_TS; pfam00889 360102001963 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102001964 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 360102001965 putative nucleotide binding site [chemical binding]; other site 360102001966 uridine monophosphate binding site [chemical binding]; other site 360102001967 homohexameric interface [polypeptide binding]; other site 360102001968 ribosome recycling factor; Reviewed; Region: frr; PRK00083 360102001969 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 360102001970 hinge region; other site 360102001971 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 360102001972 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 360102001973 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 360102001974 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 360102001975 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 360102001976 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 360102001977 catalytic residue [active] 360102001978 putative FPP diphosphate binding site; other site 360102001979 putative FPP binding hydrophobic cleft; other site 360102001980 dimer interface [polypeptide binding]; other site 360102001981 putative IPP diphosphate binding site; other site 360102001982 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 360102001983 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 360102001984 zinc metallopeptidase RseP; Provisional; Region: PRK10779 360102001985 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 360102001986 active site 360102001987 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 360102001988 protein binding site [polypeptide binding]; other site 360102001989 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 360102001990 protein binding site [polypeptide binding]; other site 360102001991 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 360102001992 putative substrate binding region [chemical binding]; other site 360102001993 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 360102001994 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 360102001995 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 360102001996 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 360102001997 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 360102001998 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 360102001999 Surface antigen; Region: Bac_surface_Ag; pfam01103 360102002000 periplasmic chaperone; Provisional; Region: PRK10780 360102002001 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 360102002002 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 360102002003 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 360102002004 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 360102002005 trimer interface [polypeptide binding]; other site 360102002006 active site 360102002007 UDP-GlcNAc binding site [chemical binding]; other site 360102002008 lipid binding site [chemical binding]; lipid-binding site 360102002009 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 360102002010 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 360102002011 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 360102002012 active site 360102002013 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 360102002014 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 360102002015 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 360102002016 RNA/DNA hybrid binding site [nucleotide binding]; other site 360102002017 active site 360102002018 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 360102002019 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 360102002020 putative active site [active] 360102002021 putative PHP Thumb interface [polypeptide binding]; other site 360102002022 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 360102002023 generic binding surface II; other site 360102002024 generic binding surface I; other site 360102002025 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 360102002026 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 360102002027 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 360102002028 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360102002029 putative metal binding site [ion binding]; other site 360102002030 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 360102002031 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 360102002032 Ligand Binding Site [chemical binding]; other site 360102002033 TilS substrate binding domain; Region: TilS; pfam09179 360102002034 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 360102002035 Cytochrome c553 [Energy production and conversion]; Region: COG2863 360102002036 Rho-binding antiterminator; Provisional; Region: PRK11625 360102002037 hypothetical protein; Provisional; Region: PRK04964 360102002038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 360102002039 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 360102002040 hypothetical protein; Provisional; Region: PRK09256 360102002041 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 360102002042 NlpE N-terminal domain; Region: NlpE; pfam04170 360102002043 prolyl-tRNA synthetase; Provisional; Region: PRK09194 360102002044 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 360102002045 dimer interface [polypeptide binding]; other site 360102002046 motif 1; other site 360102002047 active site 360102002048 motif 2; other site 360102002049 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 360102002050 putative deacylase active site [active] 360102002051 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 360102002052 active site 360102002053 motif 3; other site 360102002054 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 360102002055 anticodon binding site; other site 360102002056 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 360102002057 homodimer interaction site [polypeptide binding]; other site 360102002058 cofactor binding site; other site 360102002059 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 360102002060 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 360102002061 lipoprotein, YaeC family; Region: TIGR00363 360102002062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102002063 dimer interface [polypeptide binding]; other site 360102002064 conserved gate region; other site 360102002065 ABC-ATPase subunit interface; other site 360102002066 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 360102002067 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 360102002068 Walker A/P-loop; other site 360102002069 ATP binding site [chemical binding]; other site 360102002070 Q-loop/lid; other site 360102002071 ABC transporter signature motif; other site 360102002072 Walker B; other site 360102002073 D-loop; other site 360102002074 H-loop/switch region; other site 360102002075 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 360102002076 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 360102002077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102002078 active site 360102002079 motif I; other site 360102002080 motif II; other site 360102002081 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360102002082 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360102002083 active site 360102002084 catalytic tetrad [active] 360102002085 hypothetical protein; Provisional; Region: PRK05421 360102002086 putative catalytic site [active] 360102002087 putative phosphate binding site [ion binding]; other site 360102002088 putative metal binding site [ion binding]; other site 360102002089 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 360102002090 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 360102002091 N-acetyl-D-glucosamine binding site [chemical binding]; other site 360102002092 catalytic residue [active] 360102002093 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360102002094 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360102002095 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 360102002096 Methyltransferase domain; Region: Methyltransf_11; pfam08241 360102002097 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 360102002098 RNA/DNA hybrid binding site [nucleotide binding]; other site 360102002099 active site 360102002100 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 360102002101 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 360102002102 active site 360102002103 catalytic site [active] 360102002104 substrate binding site [chemical binding]; other site 360102002105 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 360102002106 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 360102002107 Na binding site [ion binding]; other site 360102002108 putative substrate binding site [chemical binding]; other site 360102002109 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 360102002110 transposase/IS protein; Provisional; Region: PRK09183 360102002111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102002112 Walker A motif; other site 360102002113 ATP binding site [chemical binding]; other site 360102002114 Walker B motif; other site 360102002115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102002116 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102002117 DNA-binding interface [nucleotide binding]; DNA binding site 360102002118 Integrase core domain; Region: rve; pfam00665 360102002119 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 360102002120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3657 360102002121 Predicted transcriptional regulator [Transcription]; Region: COG3636 360102002122 AAA domain; Region: AAA_25; pfam13481 360102002123 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 360102002124 Walker A motif; other site 360102002125 ATP binding site [chemical binding]; other site 360102002126 Walker B motif; other site 360102002127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 360102002128 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 360102002129 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 360102002130 active site 360102002131 metal binding site [ion binding]; metal-binding site 360102002132 interdomain interaction site; other site 360102002133 Ash protein family; Region: Phage_ASH; pfam10554 360102002134 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 360102002135 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 360102002136 Integrase; Region: Integrase_1; pfam12835 360102002137 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 360102002138 integrase; Provisional; Region: PRK09692 360102002139 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 360102002140 active site 360102002141 Int/Topo IB signature motif; other site 360102002142 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102002143 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 360102002144 SmpB-tmRNA interface; other site 360102002145 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 360102002146 putative coenzyme Q binding site [chemical binding]; other site 360102002147 hypothetical protein; Validated; Region: PRK01777 360102002148 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 360102002149 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 360102002150 recombination and repair protein; Provisional; Region: PRK10869 360102002151 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 360102002152 Walker A/P-loop; other site 360102002153 ATP binding site [chemical binding]; other site 360102002154 Q-loop/lid; other site 360102002155 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 360102002156 Q-loop/lid; other site 360102002157 ABC transporter signature motif; other site 360102002158 Walker B; other site 360102002159 D-loop; other site 360102002160 H-loop/switch region; other site 360102002161 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 360102002162 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 360102002163 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 360102002164 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 360102002165 dimer interface [polypeptide binding]; other site 360102002166 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 360102002167 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 360102002168 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 360102002169 dimer interface [polypeptide binding]; other site 360102002170 active site 360102002171 citrylCoA binding site [chemical binding]; other site 360102002172 NADH binding [chemical binding]; other site 360102002173 cationic pore residues; other site 360102002174 oxalacetate/citrate binding site [chemical binding]; other site 360102002175 coenzyme A binding site [chemical binding]; other site 360102002176 catalytic triad [active] 360102002177 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 360102002178 Iron-sulfur protein interface; other site 360102002179 proximal quinone binding site [chemical binding]; other site 360102002180 SdhD (CybS) interface [polypeptide binding]; other site 360102002181 proximal heme binding site [chemical binding]; other site 360102002182 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 360102002183 SdhC subunit interface [polypeptide binding]; other site 360102002184 proximal heme binding site [chemical binding]; other site 360102002185 cardiolipin binding site; other site 360102002186 Iron-sulfur protein interface; other site 360102002187 proximal quinone binding site [chemical binding]; other site 360102002188 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 360102002189 L-aspartate oxidase; Provisional; Region: PRK06175 360102002190 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 360102002191 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 360102002192 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 360102002193 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 360102002194 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 360102002195 TPP-binding site [chemical binding]; other site 360102002196 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 360102002197 dimer interface [polypeptide binding]; other site 360102002198 PYR/PP interface [polypeptide binding]; other site 360102002199 TPP binding site [chemical binding]; other site 360102002200 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 360102002201 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 360102002202 E3 interaction surface; other site 360102002203 lipoyl attachment site [posttranslational modification]; other site 360102002204 e3 binding domain; Region: E3_binding; pfam02817 360102002205 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 360102002206 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 360102002207 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 360102002208 CoA-ligase; Region: Ligase_CoA; pfam00549 360102002209 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 360102002210 CoA binding domain; Region: CoA_binding; smart00881 360102002211 CoA-ligase; Region: Ligase_CoA; pfam00549 360102002212 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 360102002213 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 360102002214 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 360102002215 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 360102002216 hypothetical protein; Provisional; Region: PRK10588 360102002217 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 360102002218 active site 360102002219 colicin uptake protein TolQ; Provisional; Region: PRK10801 360102002220 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 360102002221 colicin uptake protein TolR; Provisional; Region: PRK11024 360102002222 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 360102002223 TolA C-terminal; Region: TolA; pfam06519 360102002224 translocation protein TolB; Provisional; Region: tolB; PRK03629 360102002225 TolB amino-terminal domain; Region: TolB_N; pfam04052 360102002226 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 360102002227 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 360102002228 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 360102002229 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 360102002230 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360102002231 ligand binding site [chemical binding]; other site 360102002232 tol-pal system protein YbgF; Provisional; Region: PRK10803 360102002233 Tetratricopeptide repeat; Region: TPR_6; pfam13174 360102002234 quinolinate synthetase; Provisional; Region: PRK09375 360102002235 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 360102002236 zinc transporter ZitB; Provisional; Region: PRK03557 360102002237 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 360102002238 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 360102002239 transposase/IS protein; Provisional; Region: PRK09183 360102002240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102002241 Walker A motif; other site 360102002242 ATP binding site [chemical binding]; other site 360102002243 Walker B motif; other site 360102002244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102002245 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102002246 DNA-binding interface [nucleotide binding]; DNA binding site 360102002247 Integrase core domain; Region: rve; pfam00665 360102002248 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 360102002249 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 360102002250 serine transporter; Region: stp; TIGR00814 360102002251 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 360102002252 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 360102002253 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 360102002254 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 360102002255 intersubunit interface [polypeptide binding]; other site 360102002256 active site 360102002257 catalytic residue [active] 360102002258 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 360102002259 active site 360102002260 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 360102002261 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 360102002262 active site 360102002263 putative transporter; Provisional; Region: PRK04972 360102002264 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 360102002265 TrkA-C domain; Region: TrkA_C; pfam02080 360102002266 TrkA-C domain; Region: TrkA_C; pfam02080 360102002267 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 360102002268 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 360102002269 GSH binding site [chemical binding]; other site 360102002270 catalytic residues [active] 360102002271 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 360102002272 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 360102002273 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 360102002274 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 360102002275 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 360102002276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102002277 Walker A/P-loop; other site 360102002278 ATP binding site [chemical binding]; other site 360102002279 Q-loop/lid; other site 360102002280 ABC transporter signature motif; other site 360102002281 Walker B; other site 360102002282 D-loop; other site 360102002283 H-loop/switch region; other site 360102002284 TOBE domain; Region: TOBE_2; pfam08402 360102002285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102002286 dimer interface [polypeptide binding]; other site 360102002287 conserved gate region; other site 360102002288 putative PBP binding loops; other site 360102002289 ABC-ATPase subunit interface; other site 360102002290 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 360102002291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102002292 dimer interface [polypeptide binding]; other site 360102002293 conserved gate region; other site 360102002294 putative PBP binding loops; other site 360102002295 ABC-ATPase subunit interface; other site 360102002296 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 360102002297 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 360102002298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102002299 S-adenosylmethionine binding site [chemical binding]; other site 360102002300 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 360102002301 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102002302 substrate binding pocket [chemical binding]; other site 360102002303 membrane-bound complex binding site; other site 360102002304 hinge residues; other site 360102002305 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 360102002306 SPFH domain / Band 7 family; Region: Band_7; pfam01145 360102002307 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 360102002308 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 360102002309 putative ligand binding residues [chemical binding]; other site 360102002310 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102002311 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 360102002312 putative PBP binding regions; other site 360102002313 ABC-ATPase subunit interface; other site 360102002314 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 360102002315 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360102002316 Walker A/P-loop; other site 360102002317 ATP binding site [chemical binding]; other site 360102002318 Q-loop/lid; other site 360102002319 ABC transporter signature motif; other site 360102002320 Walker B; other site 360102002321 D-loop; other site 360102002322 H-loop/switch region; other site 360102002323 Nicotianamine synthase protein; Region: NAS; cl17658 360102002324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 360102002325 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 360102002326 EamA-like transporter family; Region: EamA; pfam00892 360102002327 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 360102002328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102002329 dimer interface [polypeptide binding]; other site 360102002330 conserved gate region; other site 360102002331 putative PBP binding loops; other site 360102002332 ABC-ATPase subunit interface; other site 360102002333 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360102002334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102002335 dimer interface [polypeptide binding]; other site 360102002336 conserved gate region; other site 360102002337 putative PBP binding loops; other site 360102002338 ABC-ATPase subunit interface; other site 360102002339 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 360102002340 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102002341 substrate binding pocket [chemical binding]; other site 360102002342 membrane-bound complex binding site; other site 360102002343 hinge residues; other site 360102002344 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 360102002345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102002346 Walker A/P-loop; other site 360102002347 ATP binding site [chemical binding]; other site 360102002348 Q-loop/lid; other site 360102002349 ABC transporter signature motif; other site 360102002350 Walker B; other site 360102002351 D-loop; other site 360102002352 H-loop/switch region; other site 360102002353 chorismate mutase; Provisional; Region: PRK08055 360102002354 putative lipoprotein; Provisional; Region: PRK10533 360102002355 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 360102002356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360102002357 NAD(P) binding site [chemical binding]; other site 360102002358 active site 360102002359 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 360102002360 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 360102002361 putative NAD(P) binding site [chemical binding]; other site 360102002362 putative active site [active] 360102002363 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 360102002364 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 360102002365 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 360102002366 tetramer interface [polypeptide binding]; other site 360102002367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102002368 catalytic residue [active] 360102002369 pyruvate dehydrogenase; Provisional; Region: PRK09124 360102002370 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 360102002371 PYR/PP interface [polypeptide binding]; other site 360102002372 dimer interface [polypeptide binding]; other site 360102002373 tetramer interface [polypeptide binding]; other site 360102002374 TPP binding site [chemical binding]; other site 360102002375 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 360102002376 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 360102002377 TPP-binding site [chemical binding]; other site 360102002378 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 360102002379 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 360102002380 FAD binding pocket [chemical binding]; other site 360102002381 FAD binding motif [chemical binding]; other site 360102002382 phosphate binding motif [ion binding]; other site 360102002383 beta-alpha-beta structure motif; other site 360102002384 NAD binding pocket [chemical binding]; other site 360102002385 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 360102002386 catalytic loop [active] 360102002387 iron binding site [ion binding]; other site 360102002388 hybrid cluster protein; Provisional; Region: PRK05290 360102002389 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 360102002390 ACS interaction site; other site 360102002391 CODH interaction site; other site 360102002392 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 360102002393 hybrid metal cluster; other site 360102002394 Predicted membrane protein [Function unknown]; Region: COG2431 360102002395 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 360102002396 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 360102002397 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 360102002398 putative active site [active] 360102002399 putative metal-binding site [ion binding]; other site 360102002400 Protein of unknown function (DUF535); Region: DUF535; pfam04393 360102002401 macrolide transporter subunit MacA; Provisional; Region: PRK11578 360102002402 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102002403 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102002404 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 360102002405 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 360102002406 Walker A/P-loop; other site 360102002407 ATP binding site [chemical binding]; other site 360102002408 Q-loop/lid; other site 360102002409 ABC transporter signature motif; other site 360102002410 Walker B; other site 360102002411 D-loop; other site 360102002412 H-loop/switch region; other site 360102002413 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 360102002414 FtsX-like permease family; Region: FtsX; pfam02687 360102002415 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 360102002416 DNA-binding site [nucleotide binding]; DNA binding site 360102002417 RNA-binding motif; other site 360102002418 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 360102002419 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 360102002420 Clp amino terminal domain; Region: Clp_N; pfam02861 360102002421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102002422 Walker A motif; other site 360102002423 ATP binding site [chemical binding]; other site 360102002424 Walker B motif; other site 360102002425 arginine finger; other site 360102002426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102002427 Walker A motif; other site 360102002428 ATP binding site [chemical binding]; other site 360102002429 Walker B motif; other site 360102002430 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 360102002431 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102002432 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 360102002433 rRNA binding site [nucleotide binding]; other site 360102002434 predicted 30S ribosome binding site; other site 360102002435 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 360102002436 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 360102002437 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 360102002438 Walker A/P-loop; other site 360102002439 ATP binding site [chemical binding]; other site 360102002440 Q-loop/lid; other site 360102002441 ABC transporter signature motif; other site 360102002442 Walker B; other site 360102002443 D-loop; other site 360102002444 H-loop/switch region; other site 360102002445 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 360102002446 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360102002447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102002448 Walker A/P-loop; other site 360102002449 ATP binding site [chemical binding]; other site 360102002450 Q-loop/lid; other site 360102002451 ABC transporter signature motif; other site 360102002452 Walker B; other site 360102002453 D-loop; other site 360102002454 H-loop/switch region; other site 360102002455 thioredoxin reductase; Provisional; Region: PRK10262 360102002456 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360102002457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360102002458 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 360102002459 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360102002460 putative DNA binding site [nucleotide binding]; other site 360102002461 putative Zn2+ binding site [ion binding]; other site 360102002462 AsnC family; Region: AsnC_trans_reg; pfam01037 360102002463 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 360102002464 DNA translocase FtsK; Provisional; Region: PRK10263 360102002465 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 360102002466 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 360102002467 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 360102002468 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 360102002469 recombination factor protein RarA; Reviewed; Region: PRK13342 360102002470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102002471 Walker A motif; other site 360102002472 ATP binding site [chemical binding]; other site 360102002473 Walker B motif; other site 360102002474 arginine finger; other site 360102002475 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 360102002476 seryl-tRNA synthetase; Provisional; Region: PRK05431 360102002477 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 360102002478 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 360102002479 dimer interface [polypeptide binding]; other site 360102002480 active site 360102002481 motif 1; other site 360102002482 motif 2; other site 360102002483 motif 3; other site 360102002484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102002485 putative substrate translocation pore; other site 360102002486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102002487 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 360102002488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102002489 FeS/SAM binding site; other site 360102002490 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 360102002491 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 360102002492 Pyruvate formate lyase 1; Region: PFL1; cd01678 360102002493 coenzyme A binding site [chemical binding]; other site 360102002494 active site 360102002495 catalytic residues [active] 360102002496 glycine loop; other site 360102002497 formate transporter; Provisional; Region: PRK10805 360102002498 uncharacterized domain; Region: TIGR00702 360102002499 YcaO-like family; Region: YcaO; pfam02624 360102002500 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 360102002501 active site 360102002502 homodimer interface [polypeptide binding]; other site 360102002503 homotetramer interface [polypeptide binding]; other site 360102002504 Haemagglutinin; Region: HIM; pfam05662 360102002505 YadA-like C-terminal region; Region: YadA; pfam03895 360102002506 YadA-like C-terminal region; Region: YadA; pfam03895 360102002507 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 360102002508 homodimer interface [polypeptide binding]; other site 360102002509 substrate-cofactor binding pocket; other site 360102002510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102002511 catalytic residue [active] 360102002512 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 360102002513 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 360102002514 hinge; other site 360102002515 active site 360102002516 cytidylate kinase; Provisional; Region: cmk; PRK00023 360102002517 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 360102002518 CMP-binding site; other site 360102002519 The sites determining sugar specificity; other site 360102002520 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 360102002521 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 360102002522 RNA binding site [nucleotide binding]; other site 360102002523 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 360102002524 RNA binding site [nucleotide binding]; other site 360102002525 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 360102002526 RNA binding site [nucleotide binding]; other site 360102002527 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 360102002528 RNA binding site [nucleotide binding]; other site 360102002529 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 360102002530 RNA binding site [nucleotide binding]; other site 360102002531 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 360102002532 RNA binding site [nucleotide binding]; other site 360102002533 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 360102002534 IHF dimer interface [polypeptide binding]; other site 360102002535 IHF - DNA interface [nucleotide binding]; other site 360102002536 ComEC family competence protein; Provisional; Region: PRK11539 360102002537 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 360102002538 Competence protein; Region: Competence; pfam03772 360102002539 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 360102002540 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 360102002541 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360102002542 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 360102002543 Walker A/P-loop; other site 360102002544 ATP binding site [chemical binding]; other site 360102002545 Q-loop/lid; other site 360102002546 ABC transporter signature motif; other site 360102002547 Walker B; other site 360102002548 D-loop; other site 360102002549 H-loop/switch region; other site 360102002550 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 360102002551 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 360102002552 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 360102002553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 360102002554 transposase/IS protein; Provisional; Region: PRK09183 360102002555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102002556 Walker A motif; other site 360102002557 ATP binding site [chemical binding]; other site 360102002558 Walker B motif; other site 360102002559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102002560 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102002561 DNA-binding interface [nucleotide binding]; DNA binding site 360102002562 Integrase core domain; Region: rve; pfam00665 360102002563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 360102002564 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 360102002565 DNA-binding site [nucleotide binding]; DNA binding site 360102002566 RNA-binding motif; other site 360102002567 Trm112p-like protein; Region: Trm112p; cl01066 360102002568 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 360102002569 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 360102002570 Ligand binding site; other site 360102002571 oligomer interface; other site 360102002572 hypothetical protein; Provisional; Region: PRK10593 360102002573 Methyltransferase domain; Region: Methyltransf_31; pfam13847 360102002574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102002575 S-adenosylmethionine binding site [chemical binding]; other site 360102002576 condesin subunit F; Provisional; Region: PRK05260 360102002577 condesin subunit E; Provisional; Region: PRK05256 360102002578 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 360102002579 P-loop containing region of AAA domain; Region: AAA_29; cl17516 360102002580 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 360102002581 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102002582 murein L,D-transpeptidase; Provisional; Region: PRK10594 360102002583 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 360102002584 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 360102002585 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 360102002586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 360102002587 Peptidase M15; Region: Peptidase_M15_3; cl01194 360102002588 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 360102002589 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 360102002590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360102002591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102002592 homodimer interface [polypeptide binding]; other site 360102002593 catalytic residue [active] 360102002594 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 360102002595 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 360102002596 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 360102002597 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 360102002598 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 360102002599 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 360102002600 putative dimer interface [polypeptide binding]; other site 360102002601 putative anticodon binding site; other site 360102002602 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 360102002603 homodimer interface [polypeptide binding]; other site 360102002604 motif 1; other site 360102002605 motif 2; other site 360102002606 active site 360102002607 motif 3; other site 360102002608 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 360102002609 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 360102002610 active site 360102002611 aminopeptidase N; Provisional; Region: pepN; PRK14015 360102002612 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 360102002613 active site 360102002614 Zn binding site [ion binding]; other site 360102002615 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 360102002616 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 360102002617 quinone interaction residues [chemical binding]; other site 360102002618 active site 360102002619 catalytic residues [active] 360102002620 FMN binding site [chemical binding]; other site 360102002621 substrate binding site [chemical binding]; other site 360102002622 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 360102002623 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 360102002624 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 360102002625 MOSC domain; Region: MOSC; pfam03473 360102002626 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 360102002627 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 360102002628 catalytic loop [active] 360102002629 iron binding site [ion binding]; other site 360102002630 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 360102002631 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 360102002632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102002633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102002634 S-adenosylmethionine binding site [chemical binding]; other site 360102002635 ABC transporter ATPase component; Reviewed; Region: PRK11147 360102002636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102002637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102002638 Walker A/P-loop; other site 360102002639 Walker A/P-loop; other site 360102002640 ATP binding site [chemical binding]; other site 360102002641 ATP binding site [chemical binding]; other site 360102002642 Q-loop/lid; other site 360102002643 Q-loop/lid; other site 360102002644 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360102002645 ABC transporter signature motif; other site 360102002646 Walker B; other site 360102002647 D-loop; other site 360102002648 ABC transporter; Region: ABC_tran_2; pfam12848 360102002649 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360102002650 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 360102002651 Paraquat-inducible protein A; Region: PqiA; pfam04403 360102002652 Paraquat-inducible protein A; Region: PqiA; pfam04403 360102002653 paraquat-inducible protein B; Provisional; Region: PRK10807 360102002654 mce related protein; Region: MCE; pfam02470 360102002655 mce related protein; Region: MCE; pfam02470 360102002656 mce related protein; Region: MCE; pfam02470 360102002657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 360102002658 Protein of unknown function (DUF330); Region: DUF330; pfam03886 360102002659 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102002660 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 360102002661 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 360102002662 dimer interface [polypeptide binding]; other site 360102002663 active site 360102002664 transposase/IS protein; Provisional; Region: PRK09183 360102002665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102002666 Walker A motif; other site 360102002667 ATP binding site [chemical binding]; other site 360102002668 Walker B motif; other site 360102002669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102002670 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102002671 DNA-binding interface [nucleotide binding]; DNA binding site 360102002672 Integrase core domain; Region: rve; pfam00665 360102002673 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 360102002674 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 360102002675 active site 2 [active] 360102002676 dimer interface [polypeptide binding]; other site 360102002677 active site 1 [active] 360102002678 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 360102002679 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 360102002680 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 360102002681 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102002682 outer membrane protein A; Reviewed; Region: PRK10808 360102002683 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 360102002684 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360102002685 ligand binding site [chemical binding]; other site 360102002686 SOS-response cell division inhibitor, blocks FtsZ ring formation [Cell division and chromosome partitioning]; Region: SulA; COG5404 360102002687 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 360102002688 TfoX C-terminal domain; Region: TfoX_C; pfam04994 360102002689 TIGR01666 family membrane protein; Region: YCCS 360102002690 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 360102002691 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 360102002692 Predicted membrane protein [Function unknown]; Region: COG3304 360102002693 Domain of unknown function (DUF307); Region: DUF307; pfam03733 360102002694 DNA helicase IV; Provisional; Region: helD; PRK11054 360102002695 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 360102002696 Part of AAA domain; Region: AAA_19; pfam13245 360102002697 Family description; Region: UvrD_C_2; pfam13538 360102002698 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 360102002699 active site 360102002700 dimer interfaces [polypeptide binding]; other site 360102002701 catalytic residues [active] 360102002702 hypothetical protein; Provisional; Region: PRK03641 360102002703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 360102002704 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 360102002705 heat shock protein HspQ; Provisional; Region: PRK14129 360102002706 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 360102002707 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 360102002708 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 360102002709 putative RNA binding site [nucleotide binding]; other site 360102002710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102002711 S-adenosylmethionine binding site [chemical binding]; other site 360102002712 acylphosphatase; Provisional; Region: PRK14426 360102002713 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 360102002714 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 360102002715 Integrase core domain; Region: rve; pfam00665 360102002716 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 360102002717 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 360102002718 FAD binding domain; Region: FAD_binding_4; pfam01565 360102002719 short chain dehydrogenase; Provisional; Region: PRK06172 360102002720 classical (c) SDRs; Region: SDR_c; cd05233 360102002721 NAD(P) binding site [chemical binding]; other site 360102002722 active site 360102002723 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 360102002724 active site 2 [active] 360102002725 dimer interface [polypeptide binding]; other site 360102002726 active site 1 [active] 360102002727 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 360102002728 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 360102002729 dimer interface [polypeptide binding]; other site 360102002730 active site 360102002731 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 360102002732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360102002733 NAD(P) binding site [chemical binding]; other site 360102002734 active site 360102002735 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 360102002736 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 360102002737 dimer interface [polypeptide binding]; other site 360102002738 active site 360102002739 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 360102002740 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 360102002741 substrate binding site [chemical binding]; other site 360102002742 oxyanion hole (OAH) forming residues; other site 360102002743 trimer interface [polypeptide binding]; other site 360102002744 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 360102002745 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 360102002746 substrate binding site [chemical binding]; other site 360102002747 oxyanion hole (OAH) forming residues; other site 360102002748 trimer interface [polypeptide binding]; other site 360102002749 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 360102002750 classical (c) SDRs; Region: SDR_c; cd05233 360102002751 NAD(P) binding site [chemical binding]; other site 360102002752 active site 360102002753 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 360102002754 acyl carrier protein; Validated; Region: PRK07117 360102002755 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 360102002756 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 360102002757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102002758 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102002759 DNA-binding interface [nucleotide binding]; DNA binding site 360102002760 Integrase core domain; Region: rve; pfam00665 360102002761 transposase/IS protein; Provisional; Region: PRK09183 360102002762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102002763 Walker A motif; other site 360102002764 ATP binding site [chemical binding]; other site 360102002765 Walker B motif; other site 360102002766 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 360102002767 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 360102002768 Protein of unknown function (DUF877); Region: DUF877; pfam05943 360102002769 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 360102002770 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 360102002771 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 360102002772 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 360102002773 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360102002774 ligand binding site [chemical binding]; other site 360102002775 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 360102002776 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 360102002777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102002778 Walker A motif; other site 360102002779 ATP binding site [chemical binding]; other site 360102002780 Walker B motif; other site 360102002781 arginine finger; other site 360102002782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102002783 Walker A motif; other site 360102002784 ATP binding site [chemical binding]; other site 360102002785 Walker B motif; other site 360102002786 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 360102002787 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 360102002788 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 360102002789 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 360102002790 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 360102002791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 360102002792 Peptidase family M23; Region: Peptidase_M23; pfam01551 360102002793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 360102002794 Peptidase family M23; Region: Peptidase_M23; pfam01551 360102002795 Winged helix-turn helix; Region: HTH_33; pfam13592 360102002796 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 360102002797 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 360102002798 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 360102002799 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 360102002800 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 360102002801 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 360102002802 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 360102002803 PAAR motif; Region: PAAR_motif; pfam05488 360102002804 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 360102002805 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 360102002806 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 360102002807 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 360102002808 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 360102002809 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 360102002810 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 360102002811 ImpA domain protein; Region: DUF3702; pfam12486 360102002812 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 360102002813 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 360102002814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102002815 Walker A/P-loop; other site 360102002816 ATP binding site [chemical binding]; other site 360102002817 Q-loop/lid; other site 360102002818 ABC transporter signature motif; other site 360102002819 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360102002820 Walker B; other site 360102002821 D-loop; other site 360102002822 H-loop/switch region; other site 360102002823 ABC transporter; Region: ABC_tran_2; pfam12848 360102002824 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360102002825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102002826 MULE transposase domain; Region: MULE; pfam10551 360102002827 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 360102002828 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 360102002829 ATP binding site [chemical binding]; other site 360102002830 substrate interface [chemical binding]; other site 360102002831 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 360102002832 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 360102002833 dimer interface [polypeptide binding]; other site 360102002834 putative functional site; other site 360102002835 putative MPT binding site; other site 360102002836 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102002837 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 360102002838 FeS/SAM binding site; other site 360102002839 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 360102002840 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360102002841 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 360102002842 Walker A/P-loop; other site 360102002843 ATP binding site [chemical binding]; other site 360102002844 Q-loop/lid; other site 360102002845 ABC transporter signature motif; other site 360102002846 Walker B; other site 360102002847 D-loop; other site 360102002848 H-loop/switch region; other site 360102002849 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 360102002850 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102002851 S-formylglutathione hydrolase; Region: PLN02442 360102002852 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 360102002853 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 360102002854 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 360102002855 substrate binding site [chemical binding]; other site 360102002856 catalytic Zn binding site [ion binding]; other site 360102002857 NAD binding site [chemical binding]; other site 360102002858 structural Zn binding site [ion binding]; other site 360102002859 dimer interface [polypeptide binding]; other site 360102002860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102002861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102002862 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 360102002863 putative dimerization interface [polypeptide binding]; other site 360102002864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102002865 putative substrate translocation pore; other site 360102002866 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 360102002867 GTP cyclohydrolase I; Provisional; Region: PLN03044 360102002868 active site 360102002869 Predicted membrane protein [Function unknown]; Region: COG2311 360102002870 hypothetical protein; Provisional; Region: PRK10835 360102002871 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 360102002872 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 360102002873 ligand binding site [chemical binding]; other site 360102002874 calcium binding site [ion binding]; other site 360102002875 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102002876 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 360102002877 Walker A/P-loop; other site 360102002878 ATP binding site [chemical binding]; other site 360102002879 Q-loop/lid; other site 360102002880 ABC transporter signature motif; other site 360102002881 Walker B; other site 360102002882 D-loop; other site 360102002883 H-loop/switch region; other site 360102002884 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102002885 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102002886 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102002887 TM-ABC transporter signature motif; other site 360102002888 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 360102002889 putative active site [active] 360102002890 malate dehydrogenase; Provisional; Region: PRK13529 360102002891 Malic enzyme, N-terminal domain; Region: malic; pfam00390 360102002892 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 360102002893 NAD(P) binding site [chemical binding]; other site 360102002894 cytidine deaminase; Provisional; Region: PRK09027 360102002895 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 360102002896 active site 360102002897 catalytic motif [active] 360102002898 Zn binding site [ion binding]; other site 360102002899 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 360102002900 active site 360102002901 catalytic motif [active] 360102002902 Zn binding site [ion binding]; other site 360102002903 hypothetical protein; Provisional; Region: PRK10711 360102002904 hypothetical protein; Provisional; Region: PRK01821 360102002905 putative transporter; Provisional; Region: PRK10054 360102002906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102002907 putative substrate translocation pore; other site 360102002908 Uncharacterized conserved protein [Function unknown]; Region: COG5276 360102002909 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 360102002910 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 360102002911 putative ligand binding site [chemical binding]; other site 360102002912 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102002913 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 360102002914 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 360102002915 active site 360102002916 HIGH motif; other site 360102002917 KMSKS motif; other site 360102002918 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 360102002919 tRNA binding surface [nucleotide binding]; other site 360102002920 anticodon binding site; other site 360102002921 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 360102002922 dimer interface [polypeptide binding]; other site 360102002923 putative tRNA-binding site [nucleotide binding]; other site 360102002924 antiporter inner membrane protein; Provisional; Region: PRK11670 360102002925 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 360102002926 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 360102002927 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 360102002928 ATP-binding site [chemical binding]; other site 360102002929 Sugar specificity; other site 360102002930 Pyrimidine base specificity; other site 360102002931 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 360102002932 trimer interface [polypeptide binding]; other site 360102002933 active site 360102002934 putative assembly protein; Provisional; Region: PRK10833 360102002935 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 360102002936 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 360102002937 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 360102002938 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 360102002939 Transporter associated domain; Region: CorC_HlyC; smart01091 360102002940 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 360102002941 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 360102002942 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 360102002943 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 360102002944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102002945 catalytic residue [active] 360102002946 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 360102002947 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360102002948 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 360102002949 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 360102002950 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 360102002951 IucA / IucC family; Region: IucA_IucC; pfam04183 360102002952 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 360102002953 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 360102002954 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360102002955 Walker A/P-loop; other site 360102002956 ATP binding site [chemical binding]; other site 360102002957 Q-loop/lid; other site 360102002958 ABC transporter signature motif; other site 360102002959 Walker B; other site 360102002960 D-loop; other site 360102002961 H-loop/switch region; other site 360102002962 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 360102002963 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 360102002964 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102002965 ABC-ATPase subunit interface; other site 360102002966 dimer interface [polypeptide binding]; other site 360102002967 putative PBP binding regions; other site 360102002968 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 360102002969 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102002970 ABC-ATPase subunit interface; other site 360102002971 dimer interface [polypeptide binding]; other site 360102002972 putative PBP binding regions; other site 360102002973 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 360102002974 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 360102002975 siderophore binding site; other site 360102002976 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 360102002977 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 360102002978 N-terminal plug; other site 360102002979 ligand-binding site [chemical binding]; other site 360102002980 IucA / IucC family; Region: IucA_IucC; pfam04183 360102002981 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 360102002982 IucA / IucC family; Region: IucA_IucC; pfam04183 360102002983 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 360102002984 active site 360102002985 tetramer interface; other site 360102002986 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 360102002987 active site 360102002988 tetramer interface; other site 360102002989 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 360102002990 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 360102002991 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 360102002992 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 360102002993 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 360102002994 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 360102002995 metal binding site [ion binding]; metal-binding site 360102002996 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 360102002997 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 360102002998 substrate binding site [chemical binding]; other site 360102002999 glutamase interaction surface [polypeptide binding]; other site 360102003000 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 360102003001 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 360102003002 catalytic residues [active] 360102003003 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 360102003004 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 360102003005 putative active site [active] 360102003006 oxyanion strand; other site 360102003007 catalytic triad [active] 360102003008 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 360102003009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102003010 active site 360102003011 motif I; other site 360102003012 motif II; other site 360102003013 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 360102003014 putative active site pocket [active] 360102003015 4-fold oligomerization interface [polypeptide binding]; other site 360102003016 metal binding residues [ion binding]; metal-binding site 360102003017 3-fold/trimer interface [polypeptide binding]; other site 360102003018 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 360102003019 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360102003020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102003021 homodimer interface [polypeptide binding]; other site 360102003022 catalytic residue [active] 360102003023 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 360102003024 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 360102003025 NAD binding site [chemical binding]; other site 360102003026 dimerization interface [polypeptide binding]; other site 360102003027 product binding site; other site 360102003028 substrate binding site [chemical binding]; other site 360102003029 zinc binding site [ion binding]; other site 360102003030 catalytic residues [active] 360102003031 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 360102003032 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 360102003033 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 360102003034 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 360102003035 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 360102003036 putative NAD(P) binding site [chemical binding]; other site 360102003037 Yersinia protein of unknown function (DUF3831); Region: DUF3831; pfam12908 360102003038 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102003039 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102003040 TM-ABC transporter signature motif; other site 360102003041 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102003042 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 360102003043 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 360102003044 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102003045 Walker A/P-loop; other site 360102003046 ATP binding site [chemical binding]; other site 360102003047 Q-loop/lid; other site 360102003048 ABC transporter signature motif; other site 360102003049 Walker B; other site 360102003050 D-loop; other site 360102003051 H-loop/switch region; other site 360102003052 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 360102003053 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 360102003054 putative active site [active] 360102003055 metal binding site [ion binding]; metal-binding site 360102003056 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 360102003057 exonuclease I; Provisional; Region: sbcB; PRK11779 360102003058 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 360102003059 active site 360102003060 catalytic site [active] 360102003061 substrate binding site [chemical binding]; other site 360102003062 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 360102003063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360102003064 NAD(P) binding site [chemical binding]; other site 360102003065 active site 360102003066 hypothetical protein; Provisional; Region: PRK05423 360102003067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102003068 MULE transposase domain; Region: MULE; pfam10551 360102003069 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 360102003070 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 360102003071 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 360102003072 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 360102003073 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 360102003074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102003075 putative substrate translocation pore; other site 360102003076 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 360102003077 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 360102003078 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 360102003079 NAD binding site [chemical binding]; other site 360102003080 homotetramer interface [polypeptide binding]; other site 360102003081 homodimer interface [polypeptide binding]; other site 360102003082 active site 360102003083 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 360102003084 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 360102003085 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 360102003086 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 360102003087 putative active site pocket [active] 360102003088 metal binding site [ion binding]; metal-binding site 360102003089 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 360102003090 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 360102003091 phosphate binding site [ion binding]; other site 360102003092 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 360102003093 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 360102003094 MATE family multidrug exporter; Provisional; Region: PRK10189 360102003095 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 360102003096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102003097 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360102003098 putative substrate translocation pore; other site 360102003099 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 360102003100 active site 360102003101 catalytic site [active] 360102003102 Zn binding site [ion binding]; other site 360102003103 tetramer interface [polypeptide binding]; other site 360102003104 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 360102003105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 360102003106 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 360102003107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102003108 active site 360102003109 phosphorylation site [posttranslational modification] 360102003110 intermolecular recognition site; other site 360102003111 dimerization interface [polypeptide binding]; other site 360102003112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102003113 DNA binding residues [nucleotide binding] 360102003114 dimerization interface [polypeptide binding]; other site 360102003115 DctM-like transporters; Region: DctM; pfam06808 360102003116 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 360102003117 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 360102003118 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 360102003119 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 360102003120 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 360102003121 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 360102003122 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 360102003123 Melibiase; Region: Melibiase; pfam02065 360102003124 galactoside permease; Reviewed; Region: lacY; PRK09528 360102003125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102003126 putative substrate translocation pore; other site 360102003127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102003128 MULE transposase domain; Region: MULE; pfam10551 360102003129 Transposase; Region: DEDD_Tnp_IS110; pfam01548 360102003130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 360102003131 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 360102003132 putative Mg++ binding site [ion binding]; other site 360102003133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102003134 nucleotide binding region [chemical binding]; other site 360102003135 ATP-binding site [chemical binding]; other site 360102003136 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102003137 Uncharacterized conserved protein [Function unknown]; Region: COG3595 360102003138 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 360102003139 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 360102003140 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 360102003141 FMN binding site [chemical binding]; other site 360102003142 active site 360102003143 catalytic residues [active] 360102003144 substrate binding site [chemical binding]; other site 360102003145 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 360102003146 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 360102003147 D-lactate dehydrogenase; Provisional; Region: PRK11183 360102003148 FAD binding domain; Region: FAD_binding_4; pfam01565 360102003149 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 360102003150 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 360102003151 putative active site [active] 360102003152 putative metal binding residues [ion binding]; other site 360102003153 signature motif; other site 360102003154 putative triphosphate binding site [ion binding]; other site 360102003155 dimer interface [polypeptide binding]; other site 360102003156 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 360102003157 active site 360102003158 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 360102003159 hypothetical protein; Provisional; Region: PRK10457 360102003160 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 360102003161 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 360102003162 Walker A/P-loop; other site 360102003163 ATP binding site [chemical binding]; other site 360102003164 Q-loop/lid; other site 360102003165 ABC transporter signature motif; other site 360102003166 Walker B; other site 360102003167 D-loop; other site 360102003168 H-loop/switch region; other site 360102003169 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 360102003170 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 360102003171 Transferrin; Region: Transferrin; cl02460 360102003172 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 360102003173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102003174 dimer interface [polypeptide binding]; other site 360102003175 conserved gate region; other site 360102003176 putative PBP binding loops; other site 360102003177 ABC-ATPase subunit interface; other site 360102003178 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 360102003179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102003180 dimer interface [polypeptide binding]; other site 360102003181 conserved gate region; other site 360102003182 putative PBP binding loops; other site 360102003183 ABC-ATPase subunit interface; other site 360102003184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 360102003185 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 360102003186 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 360102003187 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 360102003188 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 360102003189 putative ligand binding site [chemical binding]; other site 360102003190 HEAT repeats; Region: HEAT_2; pfam13646 360102003191 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 360102003192 TM-ABC transporter signature motif; other site 360102003193 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 360102003194 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 360102003195 TM-ABC transporter signature motif; other site 360102003196 Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674 360102003197 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 360102003198 Walker A/P-loop; other site 360102003199 ATP binding site [chemical binding]; other site 360102003200 Q-loop/lid; other site 360102003201 ABC transporter signature motif; other site 360102003202 Walker B; other site 360102003203 D-loop; other site 360102003204 H-loop/switch region; other site 360102003205 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 360102003206 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 360102003207 Walker A/P-loop; other site 360102003208 ATP binding site [chemical binding]; other site 360102003209 Q-loop/lid; other site 360102003210 ABC transporter signature motif; other site 360102003211 Walker B; other site 360102003212 D-loop; other site 360102003213 H-loop/switch region; other site 360102003214 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 360102003215 tyrosine decarboxylase; Region: PLN02880 360102003216 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 360102003217 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102003218 catalytic residue [active] 360102003219 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 360102003220 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 360102003221 active site residue [active] 360102003222 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 360102003223 active site residue [active] 360102003224 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 360102003225 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 360102003226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102003227 dimer interface [polypeptide binding]; other site 360102003228 conserved gate region; other site 360102003229 ABC-ATPase subunit interface; other site 360102003230 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 360102003231 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 360102003232 Walker A/P-loop; other site 360102003233 ATP binding site [chemical binding]; other site 360102003234 Q-loop/lid; other site 360102003235 ABC transporter signature motif; other site 360102003236 Walker B; other site 360102003237 D-loop; other site 360102003238 H-loop/switch region; other site 360102003239 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 360102003240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102003241 putative PBP binding loops; other site 360102003242 dimer interface [polypeptide binding]; other site 360102003243 ABC-ATPase subunit interface; other site 360102003244 arginine:agmatin antiporter; Provisional; Region: PRK10644 360102003245 Spore germination protein; Region: Spore_permease; cl17796 360102003246 arginine decarboxylase; Provisional; Region: PRK15029 360102003247 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 360102003248 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360102003249 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102003250 catalytic residue [active] 360102003251 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 360102003252 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 360102003253 EamA-like transporter family; Region: EamA; pfam00892 360102003254 EamA-like transporter family; Region: EamA; pfam00892 360102003255 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102003256 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102003257 DNA-binding interface [nucleotide binding]; DNA binding site 360102003258 Integrase core domain; Region: rve; pfam00665 360102003259 transposase/IS protein; Provisional; Region: PRK09183 360102003260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102003261 Walker A motif; other site 360102003262 ATP binding site [chemical binding]; other site 360102003263 Walker B motif; other site 360102003264 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 360102003265 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 360102003266 trimer interface [polypeptide binding]; other site 360102003267 eyelet of channel; other site 360102003268 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 360102003269 DEAD_2; Region: DEAD_2; pfam06733 360102003270 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 360102003271 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 360102003272 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 360102003273 tetramer interface [polypeptide binding]; other site 360102003274 heme binding pocket [chemical binding]; other site 360102003275 NADPH binding site [chemical binding]; other site 360102003276 YfaZ precursor; Region: YfaZ; pfam07437 360102003277 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 360102003278 tyrosine transporter TyrP; Provisional; Region: PRK15132 360102003279 aromatic amino acid transport protein; Region: araaP; TIGR00837 360102003280 hypothetical protein; Provisional; Region: PRK03673 360102003281 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 360102003282 putative MPT binding site; other site 360102003283 Competence-damaged protein; Region: CinA; cl00666 360102003284 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 360102003285 secondary substrate binding site; other site 360102003286 primary substrate binding site; other site 360102003287 inhibition loop; other site 360102003288 dimerization interface [polypeptide binding]; other site 360102003289 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 360102003290 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 360102003291 catalytic loop [active] 360102003292 iron binding site [ion binding]; other site 360102003293 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 360102003294 dimer interface [polypeptide binding]; other site 360102003295 putative radical transfer pathway; other site 360102003296 diiron center [ion binding]; other site 360102003297 tyrosyl radical; other site 360102003298 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 360102003299 ATP cone domain; Region: ATP-cone; pfam03477 360102003300 Class I ribonucleotide reductase; Region: RNR_I; cd01679 360102003301 active site 360102003302 dimer interface [polypeptide binding]; other site 360102003303 catalytic residues [active] 360102003304 effector binding site; other site 360102003305 R2 peptide binding site; other site 360102003306 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 360102003307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102003308 S-adenosylmethionine binding site [chemical binding]; other site 360102003309 DNA gyrase subunit A; Validated; Region: PRK05560 360102003310 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 360102003311 CAP-like domain; other site 360102003312 active site 360102003313 primary dimer interface [polypeptide binding]; other site 360102003314 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360102003315 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360102003316 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360102003317 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360102003318 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360102003319 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 360102003320 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 360102003321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102003322 dimer interface [polypeptide binding]; other site 360102003323 phosphorylation site [posttranslational modification] 360102003324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102003325 ATP binding site [chemical binding]; other site 360102003326 Mg2+ binding site [ion binding]; other site 360102003327 G-X-G motif; other site 360102003328 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 360102003329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102003330 active site 360102003331 phosphorylation site [posttranslational modification] 360102003332 intermolecular recognition site; other site 360102003333 dimerization interface [polypeptide binding]; other site 360102003334 transcriptional regulator RcsB; Provisional; Region: PRK10840 360102003335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102003336 active site 360102003337 phosphorylation site [posttranslational modification] 360102003338 intermolecular recognition site; other site 360102003339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102003340 DNA binding residues [nucleotide binding] 360102003341 dimerization interface [polypeptide binding]; other site 360102003342 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 360102003343 putative binding surface; other site 360102003344 active site 360102003345 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 360102003346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102003347 ATP binding site [chemical binding]; other site 360102003348 Mg2+ binding site [ion binding]; other site 360102003349 G-X-G motif; other site 360102003350 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 360102003351 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 360102003352 trimer interface [polypeptide binding]; other site 360102003353 eyelet of channel; other site 360102003354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 360102003355 Transposase IS200 like; Region: Y1_Tnp; cl00848 360102003356 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 360102003357 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 360102003358 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 360102003359 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 360102003360 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 360102003361 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 360102003362 Cache domain; Region: Cache_1; pfam02743 360102003363 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102003364 dimerization interface [polypeptide binding]; other site 360102003365 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 360102003366 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360102003367 dimer interface [polypeptide binding]; other site 360102003368 putative CheW interface [polypeptide binding]; other site 360102003369 Outer membrane protease [Cell envelope biogenesis, outer membrane]; Region: OmpT; COG4571 360102003370 DinI-like family; Region: DinI; cl11630 360102003371 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360102003372 non-specific DNA binding site [nucleotide binding]; other site 360102003373 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 360102003374 salt bridge; other site 360102003375 sequence-specific DNA binding site [nucleotide binding]; other site 360102003376 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 360102003377 Catalytic site [active] 360102003378 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 360102003379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 360102003380 putative aldolase; Validated; Region: PRK08130 360102003381 intersubunit interface [polypeptide binding]; other site 360102003382 active site 360102003383 Zn2+ binding site [ion binding]; other site 360102003384 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 360102003385 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 360102003386 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 360102003387 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 360102003388 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 360102003389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 360102003390 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 360102003391 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 360102003392 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 360102003393 Phage tail tube protein; Region: Tail_tube; pfam10618 360102003394 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 360102003395 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 360102003396 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 360102003397 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 360102003398 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 360102003399 Mu-like prophage protein gp45 [Function unknown]; Region: COG4384 360102003400 Mu-like prophage protein gp46 [Function unknown]; Region: COG4381 360102003401 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 360102003402 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 360102003403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 360102003404 Phage Tail Collar Domain; Region: Collar; pfam07484 360102003405 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 360102003406 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 360102003407 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 360102003408 putative active site [active] 360102003409 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 360102003410 beta-galactosidase; Region: BGL; TIGR03356 360102003411 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 360102003412 active site 360102003413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102003414 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102003415 DNA-binding interface [nucleotide binding]; DNA binding site 360102003416 Integrase core domain; Region: rve; pfam00665 360102003417 transposase/IS protein; Provisional; Region: PRK09183 360102003418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102003419 Walker A motif; other site 360102003420 ATP binding site [chemical binding]; other site 360102003421 Walker B motif; other site 360102003422 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 360102003423 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 360102003424 Sulfatase; Region: Sulfatase; cl17466 360102003425 hypothetical protein; Provisional; Region: PRK13689 360102003426 Nucleoid-associated protein [General function prediction only]; Region: COG3081 360102003427 nucleoid-associated protein NdpA; Validated; Region: PRK00378 360102003428 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102003429 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 360102003430 5S rRNA interface [nucleotide binding]; other site 360102003431 CTC domain interface [polypeptide binding]; other site 360102003432 L16 interface [polypeptide binding]; other site 360102003433 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 360102003434 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360102003435 ATP binding site [chemical binding]; other site 360102003436 putative Mg++ binding site [ion binding]; other site 360102003437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102003438 nucleotide binding region [chemical binding]; other site 360102003439 ATP-binding site [chemical binding]; other site 360102003440 Double zinc ribbon; Region: DZR; pfam12773 360102003441 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 360102003442 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360102003443 RNA binding surface [nucleotide binding]; other site 360102003444 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 360102003445 active site 360102003446 uracil binding [chemical binding]; other site 360102003447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102003448 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 360102003449 putative substrate translocation pore; other site 360102003450 hypothetical protein; Provisional; Region: PRK11835 360102003451 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 360102003452 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102003453 Walker A/P-loop; other site 360102003454 ATP binding site [chemical binding]; other site 360102003455 Q-loop/lid; other site 360102003456 ABC transporter signature motif; other site 360102003457 Walker B; other site 360102003458 D-loop; other site 360102003459 H-loop/switch region; other site 360102003460 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 360102003461 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102003462 Walker A/P-loop; other site 360102003463 ATP binding site [chemical binding]; other site 360102003464 Q-loop/lid; other site 360102003465 ABC transporter signature motif; other site 360102003466 Walker B; other site 360102003467 D-loop; other site 360102003468 H-loop/switch region; other site 360102003469 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 360102003470 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 360102003471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102003472 dimer interface [polypeptide binding]; other site 360102003473 conserved gate region; other site 360102003474 putative PBP binding loops; other site 360102003475 ABC-ATPase subunit interface; other site 360102003476 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 360102003477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102003478 dimer interface [polypeptide binding]; other site 360102003479 conserved gate region; other site 360102003480 putative PBP binding loops; other site 360102003481 ABC-ATPase subunit interface; other site 360102003482 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 360102003483 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 360102003484 phage resistance protein; Provisional; Region: PRK10551 360102003485 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 360102003486 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360102003487 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 360102003488 NlpC/P60 family; Region: NLPC_P60; pfam00877 360102003489 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 360102003490 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 360102003491 active site 360102003492 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 360102003493 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 360102003494 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 360102003495 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 360102003496 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360102003497 DNA-binding site [nucleotide binding]; DNA binding site 360102003498 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 360102003499 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 360102003500 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 360102003501 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 360102003502 mannonate dehydratase; Provisional; Region: PRK03906 360102003503 mannonate dehydratase; Region: uxuA; TIGR00695 360102003504 elongation factor P; Provisional; Region: PRK04542 360102003505 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 360102003506 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 360102003507 RNA binding site [nucleotide binding]; other site 360102003508 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 360102003509 RNA binding site [nucleotide binding]; other site 360102003510 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 360102003511 aromatic amino acid transport protein; Region: araaP; TIGR00837 360102003512 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 360102003513 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 360102003514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360102003515 NAD(P) binding site [chemical binding]; other site 360102003516 active site 360102003517 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 360102003518 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 360102003519 ligand binding site [chemical binding]; other site 360102003520 NAD binding site [chemical binding]; other site 360102003521 catalytic site [active] 360102003522 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 360102003523 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 360102003524 putative transposase OrfB; Reviewed; Region: PHA02517 360102003525 HTH-like domain; Region: HTH_21; pfam13276 360102003526 Integrase core domain; Region: rve; pfam00665 360102003527 Integrase core domain; Region: rve_2; pfam13333 360102003528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 360102003529 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102003530 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102003531 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 360102003532 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 360102003533 tetramerization interface [polypeptide binding]; other site 360102003534 NAD(P) binding site [chemical binding]; other site 360102003535 catalytic residues [active] 360102003536 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 360102003537 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 360102003538 N- and C-terminal domain interface [polypeptide binding]; other site 360102003539 active site 360102003540 MgATP binding site [chemical binding]; other site 360102003541 catalytic site [active] 360102003542 metal binding site [ion binding]; metal-binding site 360102003543 xylulose binding site [chemical binding]; other site 360102003544 homodimer interface [polypeptide binding]; other site 360102003545 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 360102003546 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360102003547 active site 360102003548 dimer interface [polypeptide binding]; other site 360102003549 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 360102003550 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 360102003551 ligand binding site [chemical binding]; other site 360102003552 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360102003553 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102003554 Walker A/P-loop; other site 360102003555 ATP binding site [chemical binding]; other site 360102003556 Q-loop/lid; other site 360102003557 ABC transporter signature motif; other site 360102003558 Walker B; other site 360102003559 D-loop; other site 360102003560 H-loop/switch region; other site 360102003561 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102003562 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102003563 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102003564 TM-ABC transporter signature motif; other site 360102003565 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 360102003566 nudix motif; other site 360102003567 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 360102003568 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 360102003569 active site 360102003570 phosphorylation site [posttranslational modification] 360102003571 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 360102003572 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 360102003573 dimerization domain swap beta strand [polypeptide binding]; other site 360102003574 regulatory protein interface [polypeptide binding]; other site 360102003575 active site 360102003576 regulatory phosphorylation site [posttranslational modification]; other site 360102003577 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 360102003578 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 360102003579 putative substrate binding site [chemical binding]; other site 360102003580 putative ATP binding site [chemical binding]; other site 360102003581 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 360102003582 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 360102003583 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 360102003584 active site 360102003585 P-loop; other site 360102003586 phosphorylation site [posttranslational modification] 360102003587 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 360102003588 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 360102003589 DNA binding site [nucleotide binding] 360102003590 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 360102003591 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102003592 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 360102003593 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 360102003594 PapC N-terminal domain; Region: PapC_N; pfam13954 360102003595 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102003596 PapC C-terminal domain; Region: PapC_C; pfam13953 360102003597 endonuclease IV; Provisional; Region: PRK01060 360102003598 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 360102003599 AP (apurinic/apyrimidinic) site pocket; other site 360102003600 DNA interaction; other site 360102003601 Metal-binding active site; metal-binding site 360102003602 Predicted membrane protein [Function unknown]; Region: COG2855 360102003603 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 360102003604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102003605 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 360102003606 putative dimerization interface [polypeptide binding]; other site 360102003607 lysine transporter; Provisional; Region: PRK10836 360102003608 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 360102003609 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 360102003610 putative ligand binding residues [chemical binding]; other site 360102003611 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 360102003612 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 360102003613 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102003614 ABC-ATPase subunit interface; other site 360102003615 dimer interface [polypeptide binding]; other site 360102003616 putative PBP binding regions; other site 360102003617 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 360102003618 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360102003619 Walker A/P-loop; other site 360102003620 ATP binding site [chemical binding]; other site 360102003621 Q-loop/lid; other site 360102003622 ABC transporter signature motif; other site 360102003623 Walker B; other site 360102003624 D-loop; other site 360102003625 H-loop/switch region; other site 360102003626 putative outer membrane receptor; Provisional; Region: PRK13513 360102003627 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 360102003628 N-terminal plug; other site 360102003629 ligand-binding site [chemical binding]; other site 360102003630 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 360102003631 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 360102003632 putative C-terminal domain interface [polypeptide binding]; other site 360102003633 putative GSH binding site (G-site) [chemical binding]; other site 360102003634 putative dimer interface [polypeptide binding]; other site 360102003635 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 360102003636 putative N-terminal domain interface [polypeptide binding]; other site 360102003637 putative dimer interface [polypeptide binding]; other site 360102003638 putative substrate binding pocket (H-site) [chemical binding]; other site 360102003639 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 360102003640 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 360102003641 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 360102003642 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 360102003643 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 360102003644 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 360102003645 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 360102003646 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 360102003647 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 360102003648 Walker A/P-loop; other site 360102003649 ATP binding site [chemical binding]; other site 360102003650 Q-loop/lid; other site 360102003651 ABC transporter signature motif; other site 360102003652 Walker B; other site 360102003653 D-loop; other site 360102003654 H-loop/switch region; other site 360102003655 NIL domain; Region: NIL; pfam09383 360102003656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102003657 dimer interface [polypeptide binding]; other site 360102003658 conserved gate region; other site 360102003659 ABC-ATPase subunit interface; other site 360102003660 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 360102003661 transposase/IS protein; Provisional; Region: PRK09183 360102003662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102003663 Walker A motif; other site 360102003664 ATP binding site [chemical binding]; other site 360102003665 Walker B motif; other site 360102003666 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102003667 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102003668 DNA-binding interface [nucleotide binding]; DNA binding site 360102003669 Integrase core domain; Region: rve; pfam00665 360102003670 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 360102003671 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 360102003672 catalytic core [active] 360102003673 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 360102003674 psiF repeat; Region: PsiF_repeat; pfam07769 360102003675 psiF repeat; Region: PsiF_repeat; pfam07769 360102003676 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 360102003677 active site 360102003678 catalytic residues [active] 360102003679 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 360102003680 galactokinase; Provisional; Region: PRK05101 360102003681 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 360102003682 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 360102003683 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 360102003684 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 360102003685 dimer interface [polypeptide binding]; other site 360102003686 active site 360102003687 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 360102003688 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 360102003689 NAD binding site [chemical binding]; other site 360102003690 homodimer interface [polypeptide binding]; other site 360102003691 active site 360102003692 substrate binding site [chemical binding]; other site 360102003693 CAAX protease self-immunity; Region: Abi; pfam02517 360102003694 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 360102003695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102003696 Walker A/P-loop; other site 360102003697 ATP binding site [chemical binding]; other site 360102003698 ABC transporter signature motif; other site 360102003699 Walker B; other site 360102003700 D-loop; other site 360102003701 H-loop/switch region; other site 360102003702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102003703 Walker A/P-loop; other site 360102003704 ATP binding site [chemical binding]; other site 360102003705 Q-loop/lid; other site 360102003706 ABC transporter signature motif; other site 360102003707 Walker B; other site 360102003708 D-loop; other site 360102003709 H-loop/switch region; other site 360102003710 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 360102003711 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 360102003712 molybdenum-pterin binding domain; Region: Mop; TIGR00638 360102003713 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 360102003714 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 360102003715 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 360102003716 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 360102003717 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 360102003718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102003719 dimer interface [polypeptide binding]; other site 360102003720 conserved gate region; other site 360102003721 putative PBP binding loops; other site 360102003722 ABC-ATPase subunit interface; other site 360102003723 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 360102003724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102003725 Walker A/P-loop; other site 360102003726 ATP binding site [chemical binding]; other site 360102003727 Q-loop/lid; other site 360102003728 ABC transporter signature motif; other site 360102003729 Walker B; other site 360102003730 D-loop; other site 360102003731 H-loop/switch region; other site 360102003732 molybdenum-pterin binding domain; Region: Mop; TIGR00638 360102003733 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 360102003734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102003735 active site 360102003736 motif I; other site 360102003737 motif II; other site 360102003738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102003739 6-phosphogluconolactonase; Provisional; Region: PRK11028 360102003740 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 360102003741 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360102003742 inhibitor-cofactor binding pocket; inhibition site 360102003743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102003744 catalytic residue [active] 360102003745 biotin synthase; Provisional; Region: PRK15108 360102003746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102003747 FeS/SAM binding site; other site 360102003748 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 360102003749 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 360102003750 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 360102003751 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102003752 catalytic residue [active] 360102003753 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 360102003754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102003755 S-adenosylmethionine binding site [chemical binding]; other site 360102003756 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 360102003757 AAA domain; Region: AAA_26; pfam13500 360102003758 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 360102003759 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 360102003760 Walker A/P-loop; other site 360102003761 ATP binding site [chemical binding]; other site 360102003762 Q-loop/lid; other site 360102003763 ABC transporter signature motif; other site 360102003764 Walker B; other site 360102003765 D-loop; other site 360102003766 H-loop/switch region; other site 360102003767 excinuclease ABC subunit B; Provisional; Region: PRK05298 360102003768 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 360102003769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360102003770 ATP-binding site [chemical binding]; other site 360102003771 ATP binding site [chemical binding]; other site 360102003772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102003773 nucleotide binding region [chemical binding]; other site 360102003774 ATP-binding site [chemical binding]; other site 360102003775 Ultra-violet resistance protein B; Region: UvrB; pfam12344 360102003776 UvrB/uvrC motif; Region: UVR; pfam02151 360102003777 Uncharacterized conserved protein [Function unknown]; Region: COG4628 360102003778 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 360102003779 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 360102003780 phosphate binding site [ion binding]; other site 360102003781 putative substrate binding pocket [chemical binding]; other site 360102003782 dimer interface [polypeptide binding]; other site 360102003783 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 360102003784 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102003785 FeS/SAM binding site; other site 360102003786 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 360102003787 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 360102003788 trimer interface [polypeptide binding]; other site 360102003789 dimer interface [polypeptide binding]; other site 360102003790 putative active site [active] 360102003791 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 360102003792 MoaE interaction surface [polypeptide binding]; other site 360102003793 MoeB interaction surface [polypeptide binding]; other site 360102003794 thiocarboxylated glycine; other site 360102003795 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 360102003796 MoaE homodimer interface [polypeptide binding]; other site 360102003797 MoaD interaction [polypeptide binding]; other site 360102003798 active site residues [active] 360102003799 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 360102003800 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 360102003801 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 360102003802 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 360102003803 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102003804 choline dehydrogenase; Validated; Region: PRK02106 360102003805 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 360102003806 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 360102003807 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 360102003808 NAD(P) binding site [chemical binding]; other site 360102003809 catalytic residues [active] 360102003810 transcriptional regulator BetI; Validated; Region: PRK00767 360102003811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360102003812 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 360102003813 choline transport protein BetT; Provisional; Region: PRK09928 360102003814 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 360102003815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102003816 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 360102003817 putative dimerization interface [polypeptide binding]; other site 360102003818 putative substrate binding pocket [chemical binding]; other site 360102003819 EamA-like transporter family; Region: EamA; pfam00892 360102003820 xanthosine phosphorylase; Region: XAPA; TIGR01699 360102003821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102003822 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102003823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102003824 zinc resistance protein; Provisional; Region: zraP; PRK11546 360102003825 dimer interface [polypeptide binding]; other site 360102003826 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 360102003827 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360102003828 putative active site [active] 360102003829 heme pocket [chemical binding]; other site 360102003830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102003831 dimer interface [polypeptide binding]; other site 360102003832 phosphorylation site [posttranslational modification] 360102003833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102003834 ATP binding site [chemical binding]; other site 360102003835 Mg2+ binding site [ion binding]; other site 360102003836 G-X-G motif; other site 360102003837 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 360102003838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102003839 active site 360102003840 phosphorylation site [posttranslational modification] 360102003841 intermolecular recognition site; other site 360102003842 dimerization interface [polypeptide binding]; other site 360102003843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102003844 Walker A motif; other site 360102003845 ATP binding site [chemical binding]; other site 360102003846 Walker B motif; other site 360102003847 arginine finger; other site 360102003848 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 360102003849 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 360102003850 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 360102003851 FMN binding site [chemical binding]; other site 360102003852 active site 360102003853 substrate binding site [chemical binding]; other site 360102003854 catalytic residue [active] 360102003855 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102003856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102003857 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 360102003858 putative effector binding pocket; other site 360102003859 putative dimerization interface [polypeptide binding]; other site 360102003860 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 360102003861 conserved hypothetical protein; Region: TIGR02118 360102003862 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 360102003863 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 360102003864 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 360102003865 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 360102003866 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360102003867 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360102003868 Walker A/P-loop; other site 360102003869 ATP binding site [chemical binding]; other site 360102003870 Q-loop/lid; other site 360102003871 ABC transporter signature motif; other site 360102003872 Walker B; other site 360102003873 D-loop; other site 360102003874 H-loop/switch region; other site 360102003875 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 360102003876 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360102003877 Walker A/P-loop; other site 360102003878 ATP binding site [chemical binding]; other site 360102003879 Q-loop/lid; other site 360102003880 ABC transporter signature motif; other site 360102003881 Walker B; other site 360102003882 D-loop; other site 360102003883 H-loop/switch region; other site 360102003884 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 360102003885 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102003886 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102003887 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 360102003888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360102003889 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 360102003890 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 360102003891 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360102003892 ATP binding site [chemical binding]; other site 360102003893 Mg++ binding site [ion binding]; other site 360102003894 motif III; other site 360102003895 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102003896 nucleotide binding region [chemical binding]; other site 360102003897 ATP-binding site [chemical binding]; other site 360102003898 DDE superfamily endonuclease; Region: DDE_3; pfam13358 360102003899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102003900 MULE transposase domain; Region: MULE; pfam10551 360102003901 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360102003902 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102003903 DNA binding site [nucleotide binding] 360102003904 domain linker motif; other site 360102003905 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 360102003906 ligand binding site [chemical binding]; other site 360102003907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102003908 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102003909 DNA-binding interface [nucleotide binding]; DNA binding site 360102003910 Integrase core domain; Region: rve; pfam00665 360102003911 transposase/IS protein; Provisional; Region: PRK09183 360102003912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102003913 Walker A motif; other site 360102003914 ATP binding site [chemical binding]; other site 360102003915 Walker B motif; other site 360102003916 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 360102003917 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 360102003918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 360102003919 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 360102003920 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 360102003921 ATP binding site [chemical binding]; other site 360102003922 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360102003923 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360102003924 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 360102003925 Walker A/P-loop; other site 360102003926 ATP binding site [chemical binding]; other site 360102003927 Q-loop/lid; other site 360102003928 ABC transporter signature motif; other site 360102003929 Walker B; other site 360102003930 D-loop; other site 360102003931 H-loop/switch region; other site 360102003932 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 360102003933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102003934 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 360102003935 YobH-like protein; Region: YobH; pfam13996 360102003936 YebO-like protein; Region: YebO; pfam13974 360102003937 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 360102003938 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 360102003939 aromatic amino acid transporter; Provisional; Region: PRK10238 360102003940 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 360102003941 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 360102003942 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 360102003943 DNA-binding site [nucleotide binding]; DNA binding site 360102003944 RNA-binding motif; other site 360102003945 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 360102003946 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 360102003947 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 360102003948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102003949 S-adenosylmethionine binding site [chemical binding]; other site 360102003950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360102003951 PAS domain; Region: PAS_9; pfam13426 360102003952 putative active site [active] 360102003953 heme pocket [chemical binding]; other site 360102003954 PAS domain S-box; Region: sensory_box; TIGR00229 360102003955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360102003956 putative active site [active] 360102003957 heme pocket [chemical binding]; other site 360102003958 PAS domain S-box; Region: sensory_box; TIGR00229 360102003959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360102003960 putative active site [active] 360102003961 heme pocket [chemical binding]; other site 360102003962 PAS fold; Region: PAS; pfam00989 360102003963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360102003964 putative active site [active] 360102003965 heme pocket [chemical binding]; other site 360102003966 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360102003967 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360102003968 metal binding site [ion binding]; metal-binding site 360102003969 active site 360102003970 I-site; other site 360102003971 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 360102003972 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 360102003973 N-terminal plug; other site 360102003974 ligand-binding site [chemical binding]; other site 360102003975 hypothetical protein; Provisional; Region: PRK11469 360102003976 Domain of unknown function DUF; Region: DUF204; pfam02659 360102003977 Domain of unknown function DUF; Region: DUF204; pfam02659 360102003978 hypothetical protein; Provisional; Region: PRK02913 360102003979 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 360102003980 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 360102003981 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 360102003982 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 360102003983 active pocket/dimerization site; other site 360102003984 active site 360102003985 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 360102003986 active site 360102003987 phosphorylation site [posttranslational modification] 360102003988 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 360102003989 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 360102003990 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 360102003991 Transporter associated domain; Region: CorC_HlyC; smart01091 360102003992 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 360102003993 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360102003994 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 360102003995 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 360102003996 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 360102003997 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 360102003998 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 360102003999 NAD binding site [chemical binding]; other site 360102004000 catalytic residues [active] 360102004001 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 360102004002 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 360102004003 putative active site [active] 360102004004 putative metal binding site [ion binding]; other site 360102004005 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 360102004006 trimer interface [polypeptide binding]; other site 360102004007 putative substrate binding pocket [chemical binding]; other site 360102004008 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 360102004009 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 360102004010 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 360102004011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102004012 putative substrate translocation pore; other site 360102004013 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 360102004014 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 360102004015 Flavin Reductases; Region: FlaRed; cl00801 360102004016 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 360102004017 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 360102004018 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 360102004019 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 360102004020 putative active site [active] 360102004021 putative CoA binding site [chemical binding]; other site 360102004022 nudix motif; other site 360102004023 metal binding site [ion binding]; metal-binding site 360102004024 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 360102004025 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 360102004026 chorismate binding enzyme; Region: Chorismate_bind; cl10555 360102004027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3140 360102004028 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 360102004029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360102004030 ATP-grasp domain; Region: ATP-grasp; pfam02222 360102004031 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 360102004032 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360102004033 ATP binding site [chemical binding]; other site 360102004034 Mg++ binding site [ion binding]; other site 360102004035 motif III; other site 360102004036 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102004037 nucleotide binding region [chemical binding]; other site 360102004038 ATP-binding site [chemical binding]; other site 360102004039 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 360102004040 YebG protein; Region: YebG; pfam07130 360102004041 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 360102004042 hypothetical protein; Provisional; Region: PRK13680 360102004043 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 360102004044 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 360102004045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102004046 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102004047 DNA-binding interface [nucleotide binding]; DNA binding site 360102004048 Integrase core domain; Region: rve; pfam00665 360102004049 transposase/IS protein; Provisional; Region: PRK09183 360102004050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102004051 Walker A motif; other site 360102004052 ATP binding site [chemical binding]; other site 360102004053 Walker B motif; other site 360102004054 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 360102004055 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 360102004056 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 360102004057 Ferritin-like domain; Region: Ferritin; pfam00210 360102004058 ferroxidase diiron center [ion binding]; other site 360102004059 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 360102004060 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 360102004061 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 360102004062 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 360102004063 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 360102004064 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 360102004065 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 360102004066 FHIPEP family; Region: FHIPEP; pfam00771 360102004067 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 360102004068 FHIPEP family; Region: FHIPEP; pfam00771 360102004069 Flagellar protein FlhE; Region: FlhE; pfam06366 360102004070 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 360102004071 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102004072 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 360102004073 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 360102004074 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 360102004075 Invasin, domain 3; Region: Invasin_D3; pfam09134 360102004076 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 360102004077 Flagellar biosynthesis/type III secretory pathway chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3418 360102004078 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 360102004079 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 360102004080 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 360102004081 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 360102004082 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 360102004083 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 360102004084 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 360102004085 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 360102004086 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 360102004087 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 360102004088 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 360102004089 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 360102004090 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 360102004091 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 360102004092 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 360102004093 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12643 360102004094 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 360102004095 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 360102004096 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 360102004097 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 360102004098 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 360102004099 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 360102004100 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 360102004101 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 360102004102 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 360102004103 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 360102004104 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 360102004105 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 360102004106 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 360102004107 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 360102004108 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 360102004109 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 360102004110 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 360102004111 short chain dehydrogenase; Validated; Region: PRK08324 360102004112 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 360102004113 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 360102004114 putative NAD(P) binding site [chemical binding]; other site 360102004115 active site 360102004116 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102004117 TM-ABC transporter signature motif; other site 360102004118 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 360102004119 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 360102004120 ligand binding site [chemical binding]; other site 360102004121 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360102004122 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102004123 Walker A/P-loop; other site 360102004124 ATP binding site [chemical binding]; other site 360102004125 Q-loop/lid; other site 360102004126 ABC transporter signature motif; other site 360102004127 Walker B; other site 360102004128 D-loop; other site 360102004129 H-loop/switch region; other site 360102004130 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102004131 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102004132 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102004133 TM-ABC transporter signature motif; other site 360102004134 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 360102004135 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360102004136 substrate binding site [chemical binding]; other site 360102004137 ATP binding site [chemical binding]; other site 360102004138 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 360102004139 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 360102004140 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 360102004141 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 360102004142 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 360102004143 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 360102004144 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 360102004145 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 360102004146 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 360102004147 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 360102004148 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 360102004149 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 360102004150 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 360102004151 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 360102004152 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 360102004153 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 360102004154 Walker A motif/ATP binding site; other site 360102004155 Walker B motif; other site 360102004156 flagellar assembly protein H; Validated; Region: fliH; PRK05687 360102004157 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 360102004158 Flagellar assembly protein FliH; Region: FliH; pfam02108 360102004159 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 360102004160 FliG C-terminal domain; Region: FliG_C; pfam01706 360102004161 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 360102004162 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 360102004163 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 360102004164 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 360102004165 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 360102004166 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 360102004167 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 360102004168 minor groove reading motif; other site 360102004169 helix-hairpin-helix signature motif; other site 360102004170 active site 360102004171 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360102004172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 360102004173 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 360102004174 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102004175 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 360102004176 flagellar protein FliS; Validated; Region: fliS; PRK05685 360102004177 flagellar capping protein; Reviewed; Region: fliD; PRK08032 360102004178 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 360102004179 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 360102004180 flagellin; Validated; Region: PRK06819 360102004181 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 360102004182 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 360102004183 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 360102004184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360102004185 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 360102004186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360102004187 DNA binding residues [nucleotide binding] 360102004188 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 360102004189 D-cysteine desulfhydrase; Validated; Region: PRK03910 360102004190 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 360102004191 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102004192 catalytic residue [active] 360102004193 cystine transporter subunit; Provisional; Region: PRK11260 360102004194 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102004195 substrate binding pocket [chemical binding]; other site 360102004196 membrane-bound complex binding site; other site 360102004197 hinge residues; other site 360102004198 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360102004199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102004200 dimer interface [polypeptide binding]; other site 360102004201 conserved gate region; other site 360102004202 putative PBP binding loops; other site 360102004203 ABC-ATPase subunit interface; other site 360102004204 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 360102004205 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 360102004206 Walker A/P-loop; other site 360102004207 ATP binding site [chemical binding]; other site 360102004208 Q-loop/lid; other site 360102004209 ABC transporter signature motif; other site 360102004210 Walker B; other site 360102004211 D-loop; other site 360102004212 H-loop/switch region; other site 360102004213 MarR family; Region: MarR_2; cl17246 360102004214 transposase/IS protein; Provisional; Region: PRK09183 360102004215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102004216 Walker A motif; other site 360102004217 ATP binding site [chemical binding]; other site 360102004218 Walker B motif; other site 360102004219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102004220 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102004221 DNA-binding interface [nucleotide binding]; DNA binding site 360102004222 Integrase core domain; Region: rve; pfam00665 360102004223 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 360102004224 Predicted transcriptional regulator [Transcription]; Region: COG3905 360102004225 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 360102004226 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 360102004227 Glutamate binding site [chemical binding]; other site 360102004228 NAD binding site [chemical binding]; other site 360102004229 catalytic residues [active] 360102004230 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 360102004231 Na binding site [ion binding]; other site 360102004232 Iron permease FTR1 family; Region: FTR1; cl00475 360102004233 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 360102004234 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 360102004235 Imelysin; Region: Peptidase_M75; pfam09375 360102004236 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 360102004237 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 360102004238 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 360102004239 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 360102004240 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 360102004241 Kelch motif; Region: Kelch_1; pfam01344 360102004242 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 360102004243 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 360102004244 GlpM protein; Region: GlpM; pfam06942 360102004245 hypothetical protein; Provisional; Region: PRK10613 360102004246 response regulator; Provisional; Region: PRK09483 360102004247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102004248 active site 360102004249 phosphorylation site [posttranslational modification] 360102004250 intermolecular recognition site; other site 360102004251 dimerization interface [polypeptide binding]; other site 360102004252 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102004253 DNA binding residues [nucleotide binding] 360102004254 dimerization interface [polypeptide binding]; other site 360102004255 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 360102004256 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 360102004257 GIY-YIG motif/motif A; other site 360102004258 active site 360102004259 catalytic site [active] 360102004260 putative DNA binding site [nucleotide binding]; other site 360102004261 metal binding site [ion binding]; metal-binding site 360102004262 UvrB/uvrC motif; Region: UVR; pfam02151 360102004263 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 360102004264 Helix-hairpin-helix motif; Region: HHH; pfam00633 360102004265 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 360102004266 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360102004267 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360102004268 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 360102004269 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 360102004270 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 360102004271 Homeodomain-like domain; Region: HTH_32; pfam13565 360102004272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 360102004273 Integrase core domain; Region: rve; pfam00665 360102004274 Integrase core domain; Region: rve_3; pfam13683 360102004275 Transposase; Region: HTH_Tnp_1; cl17663 360102004276 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 360102004277 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 360102004278 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 360102004279 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 360102004280 Protein of unknown function (DUF497); Region: DUF497; pfam04365 360102004281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 360102004282 TIR domain; Region: TIR_2; pfam13676 360102004283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102004284 MULE transposase domain; Region: MULE; pfam10551 360102004285 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102004286 Integrase core domain; Region: rve_3; cl15866 360102004287 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 360102004288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360102004289 DNA-binding site [nucleotide binding]; DNA binding site 360102004290 UTRA domain; Region: UTRA; pfam07702 360102004291 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360102004292 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360102004293 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 360102004294 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360102004295 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 360102004296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102004297 dimer interface [polypeptide binding]; other site 360102004298 conserved gate region; other site 360102004299 putative PBP binding loops; other site 360102004300 ABC-ATPase subunit interface; other site 360102004301 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360102004302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102004303 dimer interface [polypeptide binding]; other site 360102004304 conserved gate region; other site 360102004305 putative PBP binding loops; other site 360102004306 ABC-ATPase subunit interface; other site 360102004307 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 360102004308 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 360102004309 Walker A/P-loop; other site 360102004310 ATP binding site [chemical binding]; other site 360102004311 Q-loop/lid; other site 360102004312 ABC transporter signature motif; other site 360102004313 Walker B; other site 360102004314 D-loop; other site 360102004315 H-loop/switch region; other site 360102004316 TOBE domain; Region: TOBE_2; pfam08402 360102004317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102004318 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102004319 DNA-binding interface [nucleotide binding]; DNA binding site 360102004320 Integrase core domain; Region: rve; pfam00665 360102004321 transposase/IS protein; Provisional; Region: PRK09183 360102004322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102004323 Walker A motif; other site 360102004324 ATP binding site [chemical binding]; other site 360102004325 Walker B motif; other site 360102004326 Haemolysin expression modulating protein; Region: HHA; cl11501 360102004327 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 360102004328 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 360102004329 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 360102004330 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 360102004331 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 360102004332 N-terminal plug; other site 360102004333 ligand-binding site [chemical binding]; other site 360102004334 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 360102004335 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 360102004336 acyl-activating enzyme (AAE) consensus motif; other site 360102004337 active site 360102004338 AMP binding site [chemical binding]; other site 360102004339 substrate binding site [chemical binding]; other site 360102004340 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 360102004341 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 360102004342 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360102004343 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 360102004344 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 360102004345 active site 360102004346 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 360102004347 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 360102004348 Methyltransferase domain; Region: Methyltransf_12; pfam08242 360102004349 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 360102004350 KR domain; Region: KR; pfam08659 360102004351 NADP binding site [chemical binding]; other site 360102004352 active site 360102004353 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 360102004354 Condensation domain; Region: Condensation; pfam00668 360102004355 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 360102004356 Nonribosomal peptide synthase; Region: NRPS; pfam08415 360102004357 Methyltransferase domain; Region: Methyltransf_12; pfam08242 360102004358 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 360102004359 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 360102004360 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 360102004361 Condensation domain; Region: Condensation; pfam00668 360102004362 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 360102004363 Nonribosomal peptide synthase; Region: NRPS; pfam08415 360102004364 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 360102004365 acyl-activating enzyme (AAE) consensus motif; other site 360102004366 AMP binding site [chemical binding]; other site 360102004367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102004368 S-adenosylmethionine binding site [chemical binding]; other site 360102004369 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 360102004370 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 360102004371 Condensation domain; Region: Condensation; pfam00668 360102004372 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 360102004373 Nonribosomal peptide synthase; Region: NRPS; pfam08415 360102004374 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 360102004375 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 360102004376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102004377 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360102004378 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360102004379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102004380 Walker A/P-loop; other site 360102004381 ATP binding site [chemical binding]; other site 360102004382 Q-loop/lid; other site 360102004383 ABC transporter signature motif; other site 360102004384 Walker B; other site 360102004385 D-loop; other site 360102004386 H-loop/switch region; other site 360102004387 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360102004388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102004389 Walker A/P-loop; other site 360102004390 ATP binding site [chemical binding]; other site 360102004391 Q-loop/lid; other site 360102004392 ABC transporter signature motif; other site 360102004393 Walker B; other site 360102004394 D-loop; other site 360102004395 H-loop/switch region; other site 360102004396 muropeptide transporter; Validated; Region: ampG; cl17669 360102004397 salicylate synthase Irp9; Reviewed; Region: PRK06772 360102004398 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 360102004399 integrase; Provisional; Region: PRK09692 360102004400 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 360102004401 active site 360102004402 Int/Topo IB signature motif; other site 360102004403 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 360102004404 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102004405 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 360102004406 Fimbrial protein; Region: Fimbrial; cl01416 360102004407 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 360102004408 PapC N-terminal domain; Region: PapC_N; pfam13954 360102004409 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102004410 PapC C-terminal domain; Region: PapC_C; pfam13953 360102004411 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 360102004412 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102004413 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 360102004414 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 360102004415 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 360102004416 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102004417 substrate binding pocket [chemical binding]; other site 360102004418 membrane-bound complex binding site; other site 360102004419 hinge residues; other site 360102004420 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102004421 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 360102004422 substrate binding pocket [chemical binding]; other site 360102004423 membrane-bound complex binding site; other site 360102004424 hinge residues; other site 360102004425 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 360102004426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102004427 dimer interface [polypeptide binding]; other site 360102004428 phosphorylation site [posttranslational modification] 360102004429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102004430 ATP binding site [chemical binding]; other site 360102004431 Mg2+ binding site [ion binding]; other site 360102004432 G-X-G motif; other site 360102004433 Response regulator receiver domain; Region: Response_reg; pfam00072 360102004434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102004435 active site 360102004436 phosphorylation site [posttranslational modification] 360102004437 intermolecular recognition site; other site 360102004438 dimerization interface [polypeptide binding]; other site 360102004439 transcriptional regulator FimZ; Provisional; Region: PRK09935 360102004440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102004441 active site 360102004442 phosphorylation site [posttranslational modification] 360102004443 intermolecular recognition site; other site 360102004444 dimerization interface [polypeptide binding]; other site 360102004445 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102004446 DNA binding residues [nucleotide binding] 360102004447 dimerization interface [polypeptide binding]; other site 360102004448 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 360102004449 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 360102004450 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 360102004451 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 360102004452 putative active site [active] 360102004453 putative catalytic site [active] 360102004454 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 360102004455 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 360102004456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102004457 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 360102004458 putative dimerization interface [polypeptide binding]; other site 360102004459 putative substrate binding pocket [chemical binding]; other site 360102004460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102004461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102004462 ATP binding site [chemical binding]; other site 360102004463 Walker B motif; other site 360102004464 transposase/IS protein; Provisional; Region: PRK09183 360102004465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102004466 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102004467 DNA-binding interface [nucleotide binding]; DNA binding site 360102004468 Integrase core domain; Region: rve; pfam00665 360102004469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102004470 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 360102004471 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 360102004472 active site 360102004473 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102004474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102004475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 360102004476 dimerization interface [polypeptide binding]; other site 360102004477 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK12456 360102004478 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 360102004479 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360102004480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102004481 homodimer interface [polypeptide binding]; other site 360102004482 catalytic residue [active] 360102004483 L-asparagine permease; Provisional; Region: PRK15049 360102004484 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 360102004485 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 360102004486 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 360102004487 hypothetical protein; Provisional; Region: PRK09989 360102004488 glutaminase; Reviewed; Region: PRK12356 360102004489 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 360102004490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102004491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102004492 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 360102004493 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 360102004494 Predicted membrane protein [Function unknown]; Region: COG4393 360102004495 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 360102004496 Uncharacterized conserved protein [Function unknown]; Region: COG3350 360102004497 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 360102004498 FtsX-like permease family; Region: FtsX; pfam02687 360102004499 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 360102004500 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 360102004501 FtsX-like permease family; Region: FtsX; pfam02687 360102004502 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 360102004503 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 360102004504 Walker A/P-loop; other site 360102004505 ATP binding site [chemical binding]; other site 360102004506 Q-loop/lid; other site 360102004507 ABC transporter signature motif; other site 360102004508 Walker B; other site 360102004509 D-loop; other site 360102004510 H-loop/switch region; other site 360102004511 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 360102004512 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 360102004513 catalytic residues [active] 360102004514 Cytochrome c553 [Energy production and conversion]; Region: COG2863 360102004515 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 360102004516 tellurite resistance protein TehB; Provisional; Region: PRK12335 360102004517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102004518 S-adenosylmethionine binding site [chemical binding]; other site 360102004519 putative endopeptidase; Provisional; Region: PRK14576 360102004520 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 360102004521 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 360102004522 active site 360102004523 outer membrane protein; Provisional; Region: hmsH; PRK14574 360102004524 outer membrane N-deacetylase; Provisional; Region: hmsF; PRK14581 360102004525 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 360102004526 putative active site [active] 360102004527 putative metal binding site [ion binding]; other site 360102004528 N-glycosyltransferase; Provisional; Region: hmsR; PRK14583 360102004529 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 360102004530 DXD motif; other site 360102004531 hemin storage system protein; Provisional; Region: hmsS; PRK14584 360102004532 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 360102004533 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360102004534 hypothetical protein; Provisional; Region: PRK10536 360102004535 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 360102004536 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 360102004537 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 360102004538 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 360102004539 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 360102004540 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102004541 dimerization interface [polypeptide binding]; other site 360102004542 Histidine kinase; Region: HisKA_3; pfam07730 360102004543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102004544 ATP binding site [chemical binding]; other site 360102004545 Mg2+ binding site [ion binding]; other site 360102004546 G-X-G motif; other site 360102004547 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 360102004548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360102004549 DNA-binding site [nucleotide binding]; DNA binding site 360102004550 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360102004551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102004552 homodimer interface [polypeptide binding]; other site 360102004553 catalytic residue [active] 360102004554 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 360102004555 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360102004556 inhibitor-cofactor binding pocket; inhibition site 360102004557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102004558 catalytic residue [active] 360102004559 arginine succinyltransferase; Provisional; Region: PRK10456 360102004560 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 360102004561 succinylglutamic semialdehyde dehydrogenase; Region: arg_catab_astD; TIGR03240 360102004562 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 360102004563 NAD(P) binding site [chemical binding]; other site 360102004564 catalytic residues [active] 360102004565 succinylarginine dihydrolase; Provisional; Region: PRK13281 360102004566 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 360102004567 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 360102004568 putative active site [active] 360102004569 Zn binding site [ion binding]; other site 360102004570 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 360102004571 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 360102004572 trimer interface [polypeptide binding]; other site 360102004573 eyelet of channel; other site 360102004574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102004575 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102004576 DNA-binding interface [nucleotide binding]; DNA binding site 360102004577 Integrase core domain; Region: rve; pfam00665 360102004578 transposase/IS protein; Provisional; Region: PRK09183 360102004579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102004580 Walker A motif; other site 360102004581 ATP binding site [chemical binding]; other site 360102004582 Walker B motif; other site 360102004583 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 360102004584 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 360102004585 imidazolonepropionase; Validated; Region: PRK09356 360102004586 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 360102004587 active site 360102004588 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 360102004589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360102004590 DNA-binding site [nucleotide binding]; DNA binding site 360102004591 UTRA domain; Region: UTRA; pfam07702 360102004592 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 360102004593 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 360102004594 active site 360102004595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 360102004596 salicylate synthase; Region: salicyl_syn; TIGR03494 360102004597 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 360102004598 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 360102004599 active site 360102004600 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 360102004601 active site 360102004602 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 360102004603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360102004604 NAD(P) binding site [chemical binding]; other site 360102004605 active site 360102004606 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 360102004607 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 360102004608 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 360102004609 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 360102004610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360102004611 NAD(P) binding site [chemical binding]; other site 360102004612 active site 360102004613 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 360102004614 active site 360102004615 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 360102004616 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 360102004617 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 360102004618 active site 360102004619 TDP-binding site; other site 360102004620 acceptor substrate-binding pocket; other site 360102004621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102004622 MULE transposase domain; Region: MULE; pfam10551 360102004623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 360102004624 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 360102004625 Sel1-like repeats; Region: SEL1; smart00671 360102004626 Sel1-like repeats; Region: SEL1; smart00671 360102004627 Sel1-like repeats; Region: SEL1; smart00671 360102004628 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 360102004629 hypothetical protein; Provisional; Region: PRK09273 360102004630 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 360102004631 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 360102004632 Methyltransferase domain; Region: Methyltransf_12; pfam08242 360102004633 classical (c) SDRs; Region: SDR_c; cd05233 360102004634 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 360102004635 NAD(P) binding site [chemical binding]; other site 360102004636 active site 360102004637 HEAT repeats; Region: HEAT_2; pfam13646 360102004638 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 360102004639 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360102004640 catalytic site [active] 360102004641 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 360102004642 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 360102004643 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 360102004644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102004645 dimerization interface [polypeptide binding]; other site 360102004646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102004647 dimer interface [polypeptide binding]; other site 360102004648 phosphorylation site [posttranslational modification] 360102004649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102004650 ATP binding site [chemical binding]; other site 360102004651 Mg2+ binding site [ion binding]; other site 360102004652 G-X-G motif; other site 360102004653 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 360102004654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102004655 active site 360102004656 phosphorylation site [posttranslational modification] 360102004657 intermolecular recognition site; other site 360102004658 dimerization interface [polypeptide binding]; other site 360102004659 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102004660 DNA binding site [nucleotide binding] 360102004661 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 360102004662 flavodoxin; Provisional; Region: PRK06934 360102004663 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 360102004664 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 360102004665 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 360102004666 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 360102004667 active site residue [active] 360102004668 Integrase core domain; Region: rve; pfam00665 360102004669 Integrase core domain; Region: rve_3; pfam13683 360102004670 GTP-binding protein YchF; Reviewed; Region: PRK09601 360102004671 YchF GTPase; Region: YchF; cd01900 360102004672 G1 box; other site 360102004673 GTP/Mg2+ binding site [chemical binding]; other site 360102004674 Switch I region; other site 360102004675 G2 box; other site 360102004676 Switch II region; other site 360102004677 G3 box; other site 360102004678 G4 box; other site 360102004679 G5 box; other site 360102004680 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 360102004681 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 360102004682 putative active site [active] 360102004683 catalytic residue [active] 360102004684 hypothetical protein; Provisional; Region: PRK10692 360102004685 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 360102004686 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 360102004687 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360102004688 active site 360102004689 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 360102004690 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 360102004691 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 360102004692 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 360102004693 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 360102004694 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 360102004695 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 360102004696 tRNA; other site 360102004697 putative tRNA binding site [nucleotide binding]; other site 360102004698 putative NADP binding site [chemical binding]; other site 360102004699 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 360102004700 peptide chain release factor 1; Validated; Region: prfA; PRK00591 360102004701 This domain is found in peptide chain release factors; Region: PCRF; smart00937 360102004702 RF-1 domain; Region: RF-1; pfam00472 360102004703 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 360102004704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 360102004705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3094 360102004706 hypothetical protein; Provisional; Region: PRK10941 360102004707 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 360102004708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 360102004709 binding surface 360102004710 TPR motif; other site 360102004711 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 360102004712 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 360102004713 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 360102004714 transposase/IS protein; Provisional; Region: PRK09183 360102004715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102004716 Walker A motif; other site 360102004717 ATP binding site [chemical binding]; other site 360102004718 Walker B motif; other site 360102004719 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102004720 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102004721 DNA-binding interface [nucleotide binding]; DNA binding site 360102004722 Integrase core domain; Region: rve; pfam00665 360102004723 putative transporter; Provisional; Region: PRK11660 360102004724 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 360102004725 Sulfate transporter family; Region: Sulfate_transp; pfam00916 360102004726 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 360102004727 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 360102004728 putative active site [active] 360102004729 catalytic site [active] 360102004730 putative metal binding site [ion binding]; other site 360102004731 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 360102004732 hypothetical protein; Provisional; Region: PRK11622 360102004733 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 360102004734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102004735 dimer interface [polypeptide binding]; other site 360102004736 conserved gate region; other site 360102004737 putative PBP binding loops; other site 360102004738 ABC-ATPase subunit interface; other site 360102004739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102004740 dimer interface [polypeptide binding]; other site 360102004741 conserved gate region; other site 360102004742 putative PBP binding loops; other site 360102004743 ABC-ATPase subunit interface; other site 360102004744 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 360102004745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102004746 ABC transporter signature motif; other site 360102004747 Walker B; other site 360102004748 D-loop; other site 360102004749 H-loop/switch region; other site 360102004750 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102004751 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 360102004752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102004753 Walker A/P-loop; other site 360102004754 ATP binding site [chemical binding]; other site 360102004755 Q-loop/lid; other site 360102004756 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 360102004757 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 360102004758 active site 360102004759 catalytic site [active] 360102004760 Transcriptional regulators [Transcription]; Region: MarR; COG1846 360102004761 MarR family; Region: MarR_2; pfam12802 360102004762 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 360102004763 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360102004764 putative hydrolase; Validated; Region: PRK09248 360102004765 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 360102004766 active site 360102004767 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 360102004768 lipoprotein; Provisional; Region: PRK10598 360102004769 multidrug resistance protein MdtH; Provisional; Region: PRK11646 360102004770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102004771 putative substrate translocation pore; other site 360102004772 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 360102004773 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 360102004774 hypothetical protein; Provisional; Region: PRK11239 360102004775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 360102004776 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360102004777 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360102004778 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 360102004779 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 360102004780 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 360102004781 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 360102004782 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 360102004783 haemagglutination activity domain; Region: Haemagg_act; smart00912 360102004784 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 360102004785 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102004786 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102004787 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102004788 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102004789 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 360102004790 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 360102004791 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 360102004792 active site 360102004793 HIGH motif; other site 360102004794 KMSK motif region; other site 360102004795 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 360102004796 tRNA binding surface [nucleotide binding]; other site 360102004797 anticodon binding site; other site 360102004798 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 360102004799 putative metal binding site [ion binding]; other site 360102004800 copper homeostasis protein CutC; Provisional; Region: PRK11572 360102004801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102004802 S-adenosylmethionine binding site [chemical binding]; other site 360102004803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102004804 S-adenosylmethionine binding site [chemical binding]; other site 360102004805 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 360102004806 hypothetical protein; Provisional; Region: PRK10302 360102004807 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 360102004808 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 360102004809 dimer interface [polypeptide binding]; other site 360102004810 anticodon binding site; other site 360102004811 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 360102004812 homodimer interface [polypeptide binding]; other site 360102004813 motif 1; other site 360102004814 active site 360102004815 motif 2; other site 360102004816 GAD domain; Region: GAD; pfam02938 360102004817 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 360102004818 active site 360102004819 motif 3; other site 360102004820 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 360102004821 nudix motif; other site 360102004822 hypothetical protein; Validated; Region: PRK00110 360102004823 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 360102004824 active site 360102004825 putative DNA-binding cleft [nucleotide binding]; other site 360102004826 dimer interface [polypeptide binding]; other site 360102004827 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102004828 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 360102004829 RuvA N terminal domain; Region: RuvA_N; pfam01330 360102004830 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 360102004831 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 360102004832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102004833 Walker A motif; other site 360102004834 ATP binding site [chemical binding]; other site 360102004835 Walker B motif; other site 360102004836 arginine finger; other site 360102004837 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 360102004838 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 360102004839 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102004840 ABC-ATPase subunit interface; other site 360102004841 dimer interface [polypeptide binding]; other site 360102004842 putative PBP binding regions; other site 360102004843 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 360102004844 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 360102004845 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 360102004846 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 360102004847 metal binding site [ion binding]; metal-binding site 360102004848 putative peptidase; Provisional; Region: PRK11649 360102004849 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 360102004850 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360102004851 Peptidase family M23; Region: Peptidase_M23; pfam01551 360102004852 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 360102004853 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 360102004854 putative acyl-acceptor binding pocket; other site 360102004855 pyruvate kinase; Provisional; Region: PRK05826 360102004856 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 360102004857 domain interfaces; other site 360102004858 active site 360102004859 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 360102004860 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 360102004861 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 360102004862 putative active site [active] 360102004863 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 360102004864 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 360102004865 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 360102004866 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 360102004867 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 360102004868 active site 360102004869 intersubunit interface [polypeptide binding]; other site 360102004870 catalytic residue [active] 360102004871 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 360102004872 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 360102004873 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 360102004874 homotrimer interaction site [polypeptide binding]; other site 360102004875 putative active site [active] 360102004876 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 360102004877 DEAD/DEAH box helicase; Region: DEAD; pfam00270 360102004878 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 360102004879 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 360102004880 Glycoprotease family; Region: Peptidase_M22; pfam00814 360102004881 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 360102004882 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 360102004883 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 360102004884 acyl-activating enzyme (AAE) consensus motif; other site 360102004885 putative AMP binding site [chemical binding]; other site 360102004886 putative active site [active] 360102004887 putative CoA binding site [chemical binding]; other site 360102004888 ribonuclease D; Provisional; Region: PRK10829 360102004889 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 360102004890 catalytic site [active] 360102004891 putative active site [active] 360102004892 putative substrate binding site [chemical binding]; other site 360102004893 HRDC domain; Region: HRDC; pfam00570 360102004894 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 360102004895 cell division inhibitor MinD; Provisional; Region: PRK10818 360102004896 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 360102004897 Switch I; other site 360102004898 Switch II; other site 360102004899 septum formation inhibitor; Reviewed; Region: minC; PRK03511 360102004900 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 360102004901 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 360102004902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 360102004903 lytic murein transglycosylase; Region: MltB_2; TIGR02283 360102004904 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 360102004905 N-acetyl-D-glucosamine binding site [chemical binding]; other site 360102004906 catalytic residue [active] 360102004907 hypothetical protein; Provisional; Region: PRK10691 360102004908 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 360102004909 hypothetical protein; Provisional; Region: PRK05170 360102004910 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 360102004911 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 360102004912 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 360102004913 Int/Topo IB signature motif; other site 360102004914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102004915 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102004916 DNA-binding interface [nucleotide binding]; DNA binding site 360102004917 Integrase core domain; Region: rve; pfam00665 360102004918 transposase/IS protein; Provisional; Region: PRK09183 360102004919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102004920 Walker A motif; other site 360102004921 ATP binding site [chemical binding]; other site 360102004922 Walker B motif; other site 360102004923 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 360102004924 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 360102004925 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 360102004926 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 360102004927 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 360102004928 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 360102004929 Phage tail protein; Region: Phage_tail_3; pfam08813 360102004930 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 360102004931 Phage-related minor tail protein [Function unknown]; Region: COG5281 360102004932 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 360102004933 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 360102004934 Phage-related protein [Function unknown]; Region: COG4718 360102004935 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102004936 Phage-related protein [Function unknown]; Region: gp18; COG4672 360102004937 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 360102004938 MPN+ (JAMM) motif; other site 360102004939 Zinc-binding site [ion binding]; other site 360102004940 NlpC/P60 family; Region: NLPC_P60; pfam00877 360102004941 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 360102004942 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 360102004943 ligand binding surface [chemical binding]; other site 360102004944 Arc-like DNA binding domain; Region: Arc; pfam03869 360102004945 Prophage antirepressor [Transcription]; Region: COG3617 360102004946 BRO family, N-terminal domain; Region: Bro-N; smart01040 360102004947 Double zinc ribbon; Region: DZR; pfam12773 360102004948 Phage-related protein, tail component [Function unknown]; Region: COG4723 360102004949 Phage-related protein, tail component [Function unknown]; Region: COG4733 360102004950 Putative phage tail protein; Region: Phage-tail_3; pfam13550 360102004951 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 360102004952 Interdomain contacts; other site 360102004953 Cytokine receptor motif; other site 360102004954 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 360102004955 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 360102004956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102004957 MULE transposase domain; Region: MULE; pfam10551 360102004958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102004959 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360102004960 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 360102004961 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 360102004962 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102004963 catalytic residue [active] 360102004964 disulfide bond formation protein B; Provisional; Region: PRK01749 360102004965 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 360102004966 fatty acid metabolism regulator; Provisional; Region: PRK04984 360102004967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360102004968 DNA-binding site [nucleotide binding]; DNA binding site 360102004969 FadR C-terminal domain; Region: FadR_C; pfam07840 360102004970 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 360102004971 SpoVR family protein; Provisional; Region: PRK11767 360102004972 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 360102004973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 360102004974 hydroxyglutarate oxidase; Provisional; Region: PRK11728 360102004975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102004976 putative substrate translocation pore; other site 360102004977 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360102004978 Pirin-related protein [General function prediction only]; Region: COG1741 360102004979 Pirin; Region: Pirin; pfam02678 360102004980 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 360102004981 LysR family transcriptional regulator; Provisional; Region: PRK14997 360102004982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102004983 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 360102004984 putative effector binding pocket; other site 360102004985 putative dimerization interface [polypeptide binding]; other site 360102004986 EamA-like transporter family; Region: EamA; pfam00892 360102004987 hypothetical protein; Provisional; Region: PRK05325 360102004988 PrkA family serine protein kinase; Provisional; Region: PRK15455 360102004989 AAA ATPase domain; Region: AAA_16; pfam13191 360102004990 Walker A motif; other site 360102004991 ATP binding site [chemical binding]; other site 360102004992 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 360102004993 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 360102004994 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 360102004995 active site 360102004996 phosphate binding residues; other site 360102004997 catalytic residues [active] 360102004998 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 360102004999 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 360102005000 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 360102005001 methionine sulfoxide reductase B; Provisional; Region: PRK00222 360102005002 SelR domain; Region: SelR; pfam01641 360102005003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 360102005004 Isochorismatase family; Region: Isochorismatase; pfam00857 360102005005 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 360102005006 catalytic triad [active] 360102005007 metal binding site [ion binding]; metal-binding site 360102005008 conserved cis-peptide bond; other site 360102005009 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 360102005010 active site 360102005011 homodimer interface [polypeptide binding]; other site 360102005012 protease 4; Provisional; Region: PRK10949 360102005013 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 360102005014 tandem repeat interface [polypeptide binding]; other site 360102005015 oligomer interface [polypeptide binding]; other site 360102005016 active site residues [active] 360102005017 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 360102005018 tandem repeat interface [polypeptide binding]; other site 360102005019 oligomer interface [polypeptide binding]; other site 360102005020 active site residues [active] 360102005021 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 360102005022 putative FMN binding site [chemical binding]; other site 360102005023 selenophosphate synthetase; Provisional; Region: PRK00943 360102005024 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 360102005025 dimerization interface [polypeptide binding]; other site 360102005026 putative ATP binding site [chemical binding]; other site 360102005027 DNA topoisomerase III; Provisional; Region: PRK07726 360102005028 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 360102005029 active site 360102005030 putative interdomain interaction site [polypeptide binding]; other site 360102005031 putative metal-binding site [ion binding]; other site 360102005032 putative nucleotide binding site [chemical binding]; other site 360102005033 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 360102005034 domain I; other site 360102005035 DNA binding groove [nucleotide binding] 360102005036 phosphate binding site [ion binding]; other site 360102005037 domain II; other site 360102005038 domain III; other site 360102005039 nucleotide binding site [chemical binding]; other site 360102005040 catalytic site [active] 360102005041 domain IV; other site 360102005042 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 360102005043 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 360102005044 active site 360102005045 8-oxo-dGMP binding site [chemical binding]; other site 360102005046 nudix motif; other site 360102005047 metal binding site [ion binding]; metal-binding site 360102005048 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 360102005049 putative catalytic site [active] 360102005050 putative phosphate binding site [ion binding]; other site 360102005051 active site 360102005052 metal binding site A [ion binding]; metal-binding site 360102005053 DNA binding site [nucleotide binding] 360102005054 putative AP binding site [nucleotide binding]; other site 360102005055 putative metal binding site B [ion binding]; other site 360102005056 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102005057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102005058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102005059 MULE transposase domain; Region: MULE; pfam10551 360102005060 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 360102005061 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 360102005062 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 360102005063 putative active site [active] 360102005064 putative substrate binding site [chemical binding]; other site 360102005065 putative cosubstrate binding site; other site 360102005066 catalytic site [active] 360102005067 SEC-C motif; Region: SEC-C; pfam02810 360102005068 hypothetical protein; Provisional; Region: PRK04233 360102005069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102005070 active site 360102005071 response regulator of RpoS; Provisional; Region: PRK10693 360102005072 phosphorylation site [posttranslational modification] 360102005073 intermolecular recognition site; other site 360102005074 dimerization interface [polypeptide binding]; other site 360102005075 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 360102005076 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 360102005077 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 360102005078 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 360102005079 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 360102005080 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 360102005081 thymidine kinase; Provisional; Region: PRK04296 360102005082 transposase/IS protein; Provisional; Region: PRK09183 360102005083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102005084 Walker A motif; other site 360102005085 ATP binding site [chemical binding]; other site 360102005086 Walker B motif; other site 360102005087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102005088 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102005089 DNA-binding interface [nucleotide binding]; DNA binding site 360102005090 Integrase core domain; Region: rve; pfam00665 360102005091 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 360102005092 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 360102005093 putative catalytic cysteine [active] 360102005094 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 360102005095 putative active site [active] 360102005096 metal binding site [ion binding]; metal-binding site 360102005097 hypothetical protein; Provisional; Region: PRK11111 360102005098 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 360102005099 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 360102005100 peptide binding site [polypeptide binding]; other site 360102005101 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 360102005102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102005103 dimer interface [polypeptide binding]; other site 360102005104 conserved gate region; other site 360102005105 putative PBP binding loops; other site 360102005106 ABC-ATPase subunit interface; other site 360102005107 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 360102005108 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 360102005109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102005110 dimer interface [polypeptide binding]; other site 360102005111 conserved gate region; other site 360102005112 ABC-ATPase subunit interface; other site 360102005113 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 360102005114 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102005115 Walker A/P-loop; other site 360102005116 ATP binding site [chemical binding]; other site 360102005117 Q-loop/lid; other site 360102005118 ABC transporter signature motif; other site 360102005119 Walker B; other site 360102005120 D-loop; other site 360102005121 H-loop/switch region; other site 360102005122 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 360102005123 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 360102005124 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102005125 Walker A/P-loop; other site 360102005126 ATP binding site [chemical binding]; other site 360102005127 Q-loop/lid; other site 360102005128 ABC transporter signature motif; other site 360102005129 Walker B; other site 360102005130 D-loop; other site 360102005131 H-loop/switch region; other site 360102005132 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 360102005133 dsDNA-mimic protein; Reviewed; Region: PRK05094 360102005134 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 360102005135 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 360102005136 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 360102005137 putative active site [active] 360102005138 catalytic site [active] 360102005139 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 360102005140 putative active site [active] 360102005141 catalytic site [active] 360102005142 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 360102005143 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 360102005144 YciI-like protein; Reviewed; Region: PRK11370 360102005145 transport protein TonB; Provisional; Region: PRK10819 360102005146 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 360102005147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102005148 MULE transposase domain; Region: MULE; pfam10551 360102005149 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 360102005150 intracellular septation protein A; Reviewed; Region: PRK00259 360102005151 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 360102005152 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 360102005153 Sulfate transporter family; Region: Sulfate_transp; pfam00916 360102005154 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 360102005155 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 360102005156 hypothetical protein; Provisional; Region: PRK02868 360102005157 outer membrane protein W; Provisional; Region: PRK10959 360102005158 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 360102005159 BON domain; Region: BON; pfam04972 360102005160 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 360102005161 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 360102005162 substrate binding site [chemical binding]; other site 360102005163 active site 360102005164 catalytic residues [active] 360102005165 heterodimer interface [polypeptide binding]; other site 360102005166 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 360102005167 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 360102005168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102005169 catalytic residue [active] 360102005170 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 360102005171 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 360102005172 active site 360102005173 ribulose/triose binding site [chemical binding]; other site 360102005174 phosphate binding site [ion binding]; other site 360102005175 substrate (anthranilate) binding pocket [chemical binding]; other site 360102005176 product (indole) binding pocket [chemical binding]; other site 360102005177 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 360102005178 active site 360102005179 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 360102005180 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 360102005181 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 360102005182 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 360102005183 Glutamine amidotransferase class-I; Region: GATase; pfam00117 360102005184 glutamine binding [chemical binding]; other site 360102005185 catalytic triad [active] 360102005186 anthranilate synthase component I; Provisional; Region: PRK13564 360102005187 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 360102005188 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 360102005189 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 360102005190 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 360102005191 active site 360102005192 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 360102005193 hypothetical protein; Provisional; Region: PRK11630 360102005194 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 360102005195 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360102005196 RNA binding surface [nucleotide binding]; other site 360102005197 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 360102005198 probable active site [active] 360102005199 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 360102005200 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 360102005201 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 360102005202 homodimer interface [polypeptide binding]; other site 360102005203 Walker A motif; other site 360102005204 ATP binding site [chemical binding]; other site 360102005205 hydroxycobalamin binding site [chemical binding]; other site 360102005206 Walker B motif; other site 360102005207 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 360102005208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360102005209 NAD(P) binding site [chemical binding]; other site 360102005210 active site 360102005211 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 360102005212 putative inner membrane peptidase; Provisional; Region: PRK11778 360102005213 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 360102005214 tandem repeat interface [polypeptide binding]; other site 360102005215 oligomer interface [polypeptide binding]; other site 360102005216 active site residues [active] 360102005217 hypothetical protein; Provisional; Region: PRK11037 360102005218 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 360102005219 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 360102005220 active site 360102005221 interdomain interaction site; other site 360102005222 putative metal-binding site [ion binding]; other site 360102005223 nucleotide binding site [chemical binding]; other site 360102005224 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 360102005225 domain I; other site 360102005226 DNA binding groove [nucleotide binding] 360102005227 phosphate binding site [ion binding]; other site 360102005228 domain II; other site 360102005229 domain III; other site 360102005230 nucleotide binding site [chemical binding]; other site 360102005231 catalytic site [active] 360102005232 domain IV; other site 360102005233 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360102005234 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360102005235 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 360102005236 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 360102005237 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 360102005238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102005239 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 360102005240 substrate binding site [chemical binding]; other site 360102005241 putative dimerization interface [polypeptide binding]; other site 360102005242 aconitate hydratase; Validated; Region: PRK09277 360102005243 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 360102005244 substrate binding site [chemical binding]; other site 360102005245 ligand binding site [chemical binding]; other site 360102005246 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 360102005247 substrate binding site [chemical binding]; other site 360102005248 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 360102005249 dimerization interface [polypeptide binding]; other site 360102005250 active site 360102005251 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 360102005252 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 360102005253 active site 360102005254 Predicted membrane protein [Function unknown]; Region: COG3771 360102005255 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 360102005256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360102005257 TPR motif; other site 360102005258 binding surface 360102005259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 360102005260 binding surface 360102005261 TPR motif; other site 360102005262 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 360102005263 active site 360102005264 dimer interface [polypeptide binding]; other site 360102005265 translation initiation factor Sui1; Validated; Region: PRK06824 360102005266 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 360102005267 putative rRNA binding site [nucleotide binding]; other site 360102005268 lipoprotein; Provisional; Region: PRK10540 360102005269 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 360102005270 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 360102005271 intersubunit interface [polypeptide binding]; other site 360102005272 active site 360102005273 Zn2+ binding site [ion binding]; other site 360102005274 Uncharacterized conserved protein [Function unknown]; Region: COG5460 360102005275 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 360102005276 active site 360102005277 intersubunit interactions; other site 360102005278 catalytic residue [active] 360102005279 Uncharacterized small protein [Function unknown]; Region: COG2879 360102005280 carbon starvation protein A; Provisional; Region: PRK15015 360102005281 Carbon starvation protein CstA; Region: CstA; pfam02554 360102005282 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 360102005283 exoribonuclease II; Provisional; Region: PRK05054 360102005284 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 360102005285 RNB domain; Region: RNB; pfam00773 360102005286 S1 RNA binding domain; Region: S1; pfam00575 360102005287 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 360102005288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102005289 putative substrate translocation pore; other site 360102005290 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 360102005291 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 360102005292 putative NAD(P) binding site [chemical binding]; other site 360102005293 active site 360102005294 putative substrate binding site [chemical binding]; other site 360102005295 endonuclease III; Provisional; Region: PRK10702 360102005296 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 360102005297 minor groove reading motif; other site 360102005298 helix-hairpin-helix signature motif; other site 360102005299 substrate binding pocket [chemical binding]; other site 360102005300 active site 360102005301 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 360102005302 electron transport complex RsxE subunit; Provisional; Region: PRK12405 360102005303 electron transport complex protein RnfG; Validated; Region: PRK01908 360102005304 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 360102005305 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 360102005306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102005307 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 360102005308 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 360102005309 SLBB domain; Region: SLBB; pfam10531 360102005310 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 360102005311 electron transport complex protein RnfB; Provisional; Region: PRK05113 360102005312 Putative Fe-S cluster; Region: FeS; pfam04060 360102005313 4Fe-4S binding domain; Region: Fer4; pfam00037 360102005314 electron transport complex protein RsxA; Provisional; Region: PRK05151 360102005315 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 360102005316 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 360102005317 putative active site [active] 360102005318 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360102005319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102005320 Walker A/P-loop; other site 360102005321 ATP binding site [chemical binding]; other site 360102005322 Q-loop/lid; other site 360102005323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102005324 Walker B; other site 360102005325 D-loop; other site 360102005326 H-loop/switch region; other site 360102005327 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 360102005328 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102005329 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102005330 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 360102005331 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 360102005332 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360102005333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102005334 Walker A/P-loop; other site 360102005335 ATP binding site [chemical binding]; other site 360102005336 Q-loop/lid; other site 360102005337 ABC transporter signature motif; other site 360102005338 Walker B; other site 360102005339 D-loop; other site 360102005340 H-loop/switch region; other site 360102005341 L-arabinose isomerase; Provisional; Region: PRK02929 360102005342 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 360102005343 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 360102005344 trimer interface [polypeptide binding]; other site 360102005345 putative substrate binding site [chemical binding]; other site 360102005346 putative metal binding site [ion binding]; other site 360102005347 ribulokinase; Provisional; Region: PRK04123 360102005348 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 360102005349 N- and C-terminal domain interface [polypeptide binding]; other site 360102005350 active site 360102005351 MgATP binding site [chemical binding]; other site 360102005352 catalytic site [active] 360102005353 metal binding site [ion binding]; metal-binding site 360102005354 carbohydrate binding site [chemical binding]; other site 360102005355 homodimer interface [polypeptide binding]; other site 360102005356 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 360102005357 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 360102005358 ligand binding site [chemical binding]; other site 360102005359 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 360102005360 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102005361 Walker A/P-loop; other site 360102005362 ATP binding site [chemical binding]; other site 360102005363 Q-loop/lid; other site 360102005364 ABC transporter signature motif; other site 360102005365 Walker B; other site 360102005366 D-loop; other site 360102005367 H-loop/switch region; other site 360102005368 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102005369 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102005370 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102005371 TM-ABC transporter signature motif; other site 360102005372 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 360102005373 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 360102005374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102005375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102005376 putative oxidoreductase; Provisional; Region: PRK11579 360102005377 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360102005378 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 360102005379 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 360102005380 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 360102005381 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 360102005382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 360102005383 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 360102005384 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 360102005385 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 360102005386 fumarate hydratase; Reviewed; Region: fumC; PRK00485 360102005387 Class II fumarases; Region: Fumarase_classII; cd01362 360102005388 active site 360102005389 tetramer interface [polypeptide binding]; other site 360102005390 DNA replication terminus site-binding protein; Region: rep_term_tus; TIGR02648 360102005391 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 360102005392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102005393 putative substrate translocation pore; other site 360102005394 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 360102005395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102005396 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 360102005397 dimerization interface [polypeptide binding]; other site 360102005398 substrate binding pocket [chemical binding]; other site 360102005399 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 360102005400 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 360102005401 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360102005402 nucleotide binding site [chemical binding]; other site 360102005403 putative dithiobiotin synthetase; Provisional; Region: PRK12374 360102005404 AAA domain; Region: AAA_26; pfam13500 360102005405 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360102005406 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 360102005407 ligand binding site [chemical binding]; other site 360102005408 dimerization interface (closed form) [polypeptide binding]; other site 360102005409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 360102005410 transposase/IS protein; Provisional; Region: PRK09183 360102005411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102005412 Walker A motif; other site 360102005413 ATP binding site [chemical binding]; other site 360102005414 Walker B motif; other site 360102005415 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102005416 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102005417 DNA-binding interface [nucleotide binding]; DNA binding site 360102005418 Integrase core domain; Region: rve; pfam00665 360102005419 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 360102005420 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 360102005421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102005422 dimer interface [polypeptide binding]; other site 360102005423 conserved gate region; other site 360102005424 putative PBP binding loops; other site 360102005425 ABC-ATPase subunit interface; other site 360102005426 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 360102005427 Walker A/P-loop; other site 360102005428 ATP binding site [chemical binding]; other site 360102005429 ABC transporter; Region: ABC_tran; pfam00005 360102005430 Q-loop/lid; other site 360102005431 ABC transporter signature motif; other site 360102005432 AMP nucleosidase; Provisional; Region: PRK08292 360102005433 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 360102005434 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 360102005435 Protein of unknown function (DUF1602); Region: DUF1602; pfam07673 360102005436 ribonuclease E; Reviewed; Region: rne; PRK10811 360102005437 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 360102005438 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 360102005439 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 360102005440 G1 box; other site 360102005441 GTP/Mg2+ binding site [chemical binding]; other site 360102005442 G2 box; other site 360102005443 Switch I region; other site 360102005444 G3 box; other site 360102005445 Switch II region; other site 360102005446 G4 box; other site 360102005447 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 360102005448 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 360102005449 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 360102005450 PYR/PP interface [polypeptide binding]; other site 360102005451 dimer interface [polypeptide binding]; other site 360102005452 TPP binding site [chemical binding]; other site 360102005453 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 360102005454 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 360102005455 TPP-binding site [chemical binding]; other site 360102005456 dimer interface [polypeptide binding]; other site 360102005457 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 360102005458 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 360102005459 putative valine binding site [chemical binding]; other site 360102005460 dimer interface [polypeptide binding]; other site 360102005461 dUMP phosphatase; Provisional; Region: PRK09449 360102005462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102005463 motif II; other site 360102005464 tellurite resistance protein terB; Region: terB; cd07176 360102005465 putative metal binding site [ion binding]; other site 360102005466 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 360102005467 alkaline phosphatase; Provisional; Region: PRK10518 360102005468 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 360102005469 dimer interface [polypeptide binding]; other site 360102005470 active site 360102005471 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 360102005472 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 360102005473 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 360102005474 DNA binding site [nucleotide binding] 360102005475 active site 360102005476 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 360102005477 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 360102005478 ligand binding site [chemical binding]; other site 360102005479 flexible hinge region; other site 360102005480 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 360102005481 putative switch regulator; other site 360102005482 non-specific DNA interactions [nucleotide binding]; other site 360102005483 DNA binding site [nucleotide binding] 360102005484 sequence specific DNA binding site [nucleotide binding]; other site 360102005485 putative cAMP binding site [chemical binding]; other site 360102005486 universal stress protein UspE; Provisional; Region: PRK11175 360102005487 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 360102005488 Ligand Binding Site [chemical binding]; other site 360102005489 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 360102005490 Ligand Binding Site [chemical binding]; other site 360102005491 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 360102005492 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 360102005493 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 360102005494 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 360102005495 ligand binding site [chemical binding]; other site 360102005496 homodimer interface [polypeptide binding]; other site 360102005497 NAD(P) binding site [chemical binding]; other site 360102005498 trimer interface B [polypeptide binding]; other site 360102005499 trimer interface A [polypeptide binding]; other site 360102005500 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 360102005501 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 360102005502 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 360102005503 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 360102005504 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 360102005505 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 360102005506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102005507 active site 360102005508 phosphorylation site [posttranslational modification] 360102005509 intermolecular recognition site; other site 360102005510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102005511 DNA binding site [nucleotide binding] 360102005512 sensor protein RstB; Provisional; Region: PRK10604 360102005513 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102005514 dimerization interface [polypeptide binding]; other site 360102005515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102005516 dimer interface [polypeptide binding]; other site 360102005517 phosphorylation site [posttranslational modification] 360102005518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102005519 ATP binding site [chemical binding]; other site 360102005520 Mg2+ binding site [ion binding]; other site 360102005521 G-X-G motif; other site 360102005522 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 360102005523 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 360102005524 active site 360102005525 Zn binding site [ion binding]; other site 360102005526 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102005527 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 360102005528 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 360102005529 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 360102005530 Transposase; Region: DEDD_Tnp_IS110; pfam01548 360102005531 hypothetical protein; Provisional; Region: PRK03757 360102005532 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 360102005533 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 360102005534 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 360102005535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360102005536 non-specific DNA binding site [nucleotide binding]; other site 360102005537 salt bridge; other site 360102005538 sequence-specific DNA binding site [nucleotide binding]; other site 360102005539 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 360102005540 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 360102005541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102005542 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102005543 DNA-binding interface [nucleotide binding]; DNA binding site 360102005544 Integrase core domain; Region: rve; pfam00665 360102005545 transposase/IS protein; Provisional; Region: PRK09183 360102005546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102005547 Walker A motif; other site 360102005548 ATP binding site [chemical binding]; other site 360102005549 Walker B motif; other site 360102005550 DEAD-like helicases superfamily; Region: DEXDc; smart00487 360102005551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360102005552 ATP binding site [chemical binding]; other site 360102005553 putative Mg++ binding site [ion binding]; other site 360102005554 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102005555 nucleotide binding region [chemical binding]; other site 360102005556 ATP-binding site [chemical binding]; other site 360102005557 Helicase associated domain (HA2); Region: HA2; pfam04408 360102005558 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 360102005559 azoreductase; Reviewed; Region: PRK00170 360102005560 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 360102005561 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 360102005562 MarR family; Region: MarR_2; pfam12802 360102005563 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 360102005564 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 360102005565 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 360102005566 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 360102005567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 360102005568 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 360102005569 hypothetical protein; Provisional; Region: PRK10695 360102005570 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 360102005571 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 360102005572 putative ligand binding site [chemical binding]; other site 360102005573 putative NAD binding site [chemical binding]; other site 360102005574 catalytic site [active] 360102005575 heat-inducible protein; Provisional; Region: PRK10449 360102005576 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 360102005577 Domain of unknown function (DUF333); Region: DUF333; pfam03891 360102005578 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 360102005579 MgtC family; Region: MgtC; pfam02308 360102005580 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 360102005581 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 360102005582 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 360102005583 dimer interface [polypeptide binding]; other site 360102005584 PYR/PP interface [polypeptide binding]; other site 360102005585 TPP binding site [chemical binding]; other site 360102005586 substrate binding site [chemical binding]; other site 360102005587 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 360102005588 Domain of unknown function; Region: EKR; pfam10371 360102005589 4Fe-4S binding domain; Region: Fer4_6; pfam12837 360102005590 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 360102005591 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 360102005592 TPP-binding site [chemical binding]; other site 360102005593 dimer interface [polypeptide binding]; other site 360102005594 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 360102005595 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 360102005596 Ligand Binding Site [chemical binding]; other site 360102005597 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 360102005598 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 360102005599 substrate binding pocket [chemical binding]; other site 360102005600 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 360102005601 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 360102005602 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 360102005603 DNA binding residues [nucleotide binding] 360102005604 dimer interface [polypeptide binding]; other site 360102005605 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 360102005606 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 360102005607 Cl binding site [ion binding]; other site 360102005608 oligomer interface [polypeptide binding]; other site 360102005609 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 360102005610 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 360102005611 peptide binding site [polypeptide binding]; other site 360102005612 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 360102005613 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 360102005614 putative active site [active] 360102005615 Zn binding site [ion binding]; other site 360102005616 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 360102005617 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 360102005618 active site 360102005619 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 360102005620 dimer interface [polypeptide binding]; other site 360102005621 catalytic triad [active] 360102005622 peroxidatic and resolving cysteines [active] 360102005623 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102005624 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 360102005625 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 360102005626 PAS domain; Region: PAS; smart00091 360102005627 putative active site [active] 360102005628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102005629 Walker A motif; other site 360102005630 ATP binding site [chemical binding]; other site 360102005631 Walker B motif; other site 360102005632 arginine finger; other site 360102005633 Uncharacterized conserved protein [Function unknown]; Region: COG5642 360102005634 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 360102005635 Uncharacterized conserved protein [Function unknown]; Region: COG5654 360102005636 hypothetical protein; Provisional; Region: PRK05415 360102005637 Domain of unknown function (DUF697); Region: DUF697; cl12064 360102005638 Predicted ATPase [General function prediction only]; Region: COG3106 360102005639 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; pfam09584 360102005640 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 360102005641 phage shock protein C; Region: phageshock_pspC; TIGR02978 360102005642 phage shock protein B; Provisional; Region: pspB; PRK09458 360102005643 phage shock protein PspA; Provisional; Region: PRK10698 360102005644 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 360102005645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102005646 Walker A motif; other site 360102005647 ATP binding site [chemical binding]; other site 360102005648 Walker B motif; other site 360102005649 arginine finger; other site 360102005650 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 360102005651 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102005652 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 360102005653 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 360102005654 peptide binding site [polypeptide binding]; other site 360102005655 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 360102005656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102005657 dimer interface [polypeptide binding]; other site 360102005658 conserved gate region; other site 360102005659 putative PBP binding loops; other site 360102005660 ABC-ATPase subunit interface; other site 360102005661 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 360102005662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102005663 putative PBP binding loops; other site 360102005664 dimer interface [polypeptide binding]; other site 360102005665 ABC-ATPase subunit interface; other site 360102005666 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 360102005667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102005668 Walker A/P-loop; other site 360102005669 ATP binding site [chemical binding]; other site 360102005670 Q-loop/lid; other site 360102005671 ABC transporter signature motif; other site 360102005672 Walker B; other site 360102005673 D-loop; other site 360102005674 H-loop/switch region; other site 360102005675 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 360102005676 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 360102005677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102005678 Walker A/P-loop; other site 360102005679 ATP binding site [chemical binding]; other site 360102005680 Q-loop/lid; other site 360102005681 ABC transporter signature motif; other site 360102005682 Walker B; other site 360102005683 D-loop; other site 360102005684 H-loop/switch region; other site 360102005685 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 360102005686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 360102005687 Uncharacterized conserved protein [Function unknown]; Region: COG2128 360102005688 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 360102005689 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 360102005690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102005691 putative substrate translocation pore; other site 360102005692 POT family; Region: PTR2; pfam00854 360102005693 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 360102005694 hypothetical protein; Provisional; Region: PRK10515 360102005695 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 360102005696 N-terminal domain interface [polypeptide binding]; other site 360102005697 pyridoxamine kinase; Validated; Region: PRK05756 360102005698 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 360102005699 dimer interface [polypeptide binding]; other site 360102005700 pyridoxal binding site [chemical binding]; other site 360102005701 ATP binding site [chemical binding]; other site 360102005702 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 360102005703 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 360102005704 active site 360102005705 HIGH motif; other site 360102005706 dimer interface [polypeptide binding]; other site 360102005707 KMSKS motif; other site 360102005708 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360102005709 RNA binding surface [nucleotide binding]; other site 360102005710 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 360102005711 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 360102005712 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 360102005713 Predicted periplasmic protein [General function prediction only]; Region: COG3895 360102005714 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 360102005715 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 360102005716 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 360102005717 transcriptional regulator SlyA; Provisional; Region: PRK03573 360102005718 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 360102005719 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360102005720 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360102005721 active site 360102005722 catalytic tetrad [active] 360102005723 Predicted Fe-S protein [General function prediction only]; Region: COG3313 360102005724 putative metal dependent hydrolase; Provisional; Region: PRK11598 360102005725 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 360102005726 Sulfatase; Region: Sulfatase; pfam00884 360102005727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 360102005728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360102005729 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 360102005730 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 360102005731 FMN binding site [chemical binding]; other site 360102005732 active site 360102005733 substrate binding site [chemical binding]; other site 360102005734 catalytic residue [active] 360102005735 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 360102005736 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 360102005737 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 360102005738 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 360102005739 dimer interface [polypeptide binding]; other site 360102005740 active site 360102005741 metal binding site [ion binding]; metal-binding site 360102005742 glutathione binding site [chemical binding]; other site 360102005743 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 360102005744 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 360102005745 dimer interface [polypeptide binding]; other site 360102005746 catalytic site [active] 360102005747 putative active site [active] 360102005748 putative substrate binding site [chemical binding]; other site 360102005749 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 360102005750 putative GSH binding site [chemical binding]; other site 360102005751 catalytic residues [active] 360102005752 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 360102005753 NlpC/P60 family; Region: NLPC_P60; cl17555 360102005754 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 360102005755 NlpC/P60 family; Region: NLPC_P60; pfam00877 360102005756 superoxide dismutase; Provisional; Region: PRK10543 360102005757 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 360102005758 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 360102005759 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 360102005760 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102005761 DNA binding site [nucleotide binding] 360102005762 domain linker motif; other site 360102005763 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 360102005764 dimerization interface [polypeptide binding]; other site 360102005765 ligand binding site [chemical binding]; other site 360102005766 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 360102005767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102005768 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360102005769 dimerization interface [polypeptide binding]; other site 360102005770 putative transporter; Provisional; Region: PRK11043 360102005771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102005772 putative substrate translocation pore; other site 360102005773 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 360102005774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102005775 S-adenosylmethionine binding site [chemical binding]; other site 360102005776 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 360102005777 Lumazine binding domain; Region: Lum_binding; pfam00677 360102005778 Lumazine binding domain; Region: Lum_binding; pfam00677 360102005779 multidrug efflux protein; Reviewed; Region: PRK01766 360102005780 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 360102005781 cation binding site [ion binding]; other site 360102005782 pyruvate kinase; Provisional; Region: PRK09206 360102005783 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 360102005784 domain interfaces; other site 360102005785 active site 360102005786 murein lipoprotein; Provisional; Region: PRK15396 360102005787 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102005788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102005789 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102005790 DNA-binding interface [nucleotide binding]; DNA binding site 360102005791 Integrase core domain; Region: rve; pfam00665 360102005792 transposase/IS protein; Provisional; Region: PRK09183 360102005793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102005794 Walker A motif; other site 360102005795 ATP binding site [chemical binding]; other site 360102005796 Walker B motif; other site 360102005797 L,D-transpeptidase; Provisional; Region: PRK10190 360102005798 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 360102005799 cysteine desufuration protein SufE; Provisional; Region: PRK09296 360102005800 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 360102005801 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 360102005802 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102005803 catalytic residue [active] 360102005804 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 360102005805 FeS assembly protein SufD; Region: sufD; TIGR01981 360102005806 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 360102005807 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 360102005808 Walker A/P-loop; other site 360102005809 ATP binding site [chemical binding]; other site 360102005810 Q-loop/lid; other site 360102005811 ABC transporter signature motif; other site 360102005812 Walker B; other site 360102005813 D-loop; other site 360102005814 H-loop/switch region; other site 360102005815 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 360102005816 putative ABC transporter; Region: ycf24; CHL00085 360102005817 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 360102005818 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 360102005819 CoenzymeA binding site [chemical binding]; other site 360102005820 subunit interaction site [polypeptide binding]; other site 360102005821 PHB binding site; other site 360102005822 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 360102005823 FAD binding domain; Region: FAD_binding_4; pfam01565 360102005824 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 360102005825 putative inner membrane protein; Provisional; Region: PRK10983 360102005826 Domain of unknown function DUF20; Region: UPF0118; pfam01594 360102005827 phosphoenolpyruvate synthase; Validated; Region: PRK06464 360102005828 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 360102005829 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 360102005830 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 360102005831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 360102005832 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 360102005833 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 360102005834 Uncharacterized conserved protein [Function unknown]; Region: COG0397 360102005835 hypothetical protein; Validated; Region: PRK00029 360102005836 hypothetical protein; Validated; Region: PRK00029 360102005837 Uncharacterized conserved protein [Function unknown]; Region: COG0397 360102005838 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 360102005839 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 360102005840 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 360102005841 NlpC/P60 family; Region: NLPC_P60; pfam00877 360102005842 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 360102005843 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 360102005844 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 360102005845 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 360102005846 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 360102005847 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 360102005848 putative active site [active] 360102005849 putative catalytic site [active] 360102005850 putative Zn binding site [ion binding]; other site 360102005851 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 360102005852 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 360102005853 active site 360102005854 substrate binding site [chemical binding]; other site 360102005855 cosubstrate binding site; other site 360102005856 catalytic site [active] 360102005857 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 360102005858 active site 360102005859 hexamer interface [polypeptide binding]; other site 360102005860 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 360102005861 NAD binding site [chemical binding]; other site 360102005862 substrate binding site [chemical binding]; other site 360102005863 active site 360102005864 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 360102005865 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 360102005866 Ligand binding site; other site 360102005867 Putative Catalytic site; other site 360102005868 DXD motif; other site 360102005869 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 360102005870 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 360102005871 inhibitor-cofactor binding pocket; inhibition site 360102005872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102005873 catalytic residue [active] 360102005874 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 360102005875 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360102005876 Walker A/P-loop; other site 360102005877 ATP binding site [chemical binding]; other site 360102005878 Q-loop/lid; other site 360102005879 ABC transporter signature motif; other site 360102005880 Walker B; other site 360102005881 D-loop; other site 360102005882 H-loop/switch region; other site 360102005883 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 360102005884 catalytic residues [active] 360102005885 dimer interface [polypeptide binding]; other site 360102005886 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 360102005887 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102005888 ABC-ATPase subunit interface; other site 360102005889 dimer interface [polypeptide binding]; other site 360102005890 putative PBP binding regions; other site 360102005891 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 360102005892 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 360102005893 IHF dimer interface [polypeptide binding]; other site 360102005894 IHF - DNA interface [nucleotide binding]; other site 360102005895 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 360102005896 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 360102005897 putative tRNA-binding site [nucleotide binding]; other site 360102005898 B3/4 domain; Region: B3_4; pfam03483 360102005899 tRNA synthetase B5 domain; Region: B5; smart00874 360102005900 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 360102005901 dimer interface [polypeptide binding]; other site 360102005902 motif 1; other site 360102005903 motif 3; other site 360102005904 motif 2; other site 360102005905 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 360102005906 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 360102005907 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 360102005908 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 360102005909 dimer interface [polypeptide binding]; other site 360102005910 motif 1; other site 360102005911 active site 360102005912 motif 2; other site 360102005913 motif 3; other site 360102005914 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 360102005915 23S rRNA binding site [nucleotide binding]; other site 360102005916 L21 binding site [polypeptide binding]; other site 360102005917 L13 binding site [polypeptide binding]; other site 360102005918 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 360102005919 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 360102005920 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 360102005921 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 360102005922 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 360102005923 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 360102005924 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 360102005925 active site 360102005926 dimer interface [polypeptide binding]; other site 360102005927 motif 1; other site 360102005928 motif 2; other site 360102005929 motif 3; other site 360102005930 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 360102005931 anticodon binding site; other site 360102005932 KTSC domain; Region: KTSC; pfam13619 360102005933 inner membrane protein; Provisional; Region: PRK10995 360102005934 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 360102005935 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 360102005936 N-acetyl-D-glucosamine binding site [chemical binding]; other site 360102005937 catalytic residue [active] 360102005938 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 360102005939 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 360102005940 metal binding site [ion binding]; metal-binding site 360102005941 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 360102005942 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 360102005943 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 360102005944 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102005945 ABC-ATPase subunit interface; other site 360102005946 dimer interface [polypeptide binding]; other site 360102005947 putative PBP binding regions; other site 360102005948 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 360102005949 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102005950 ABC-ATPase subunit interface; other site 360102005951 dimer interface [polypeptide binding]; other site 360102005952 putative PBP binding regions; other site 360102005953 Phosphotransferase enzyme family; Region: APH; pfam01636 360102005954 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 360102005955 active site 360102005956 ATP binding site [chemical binding]; other site 360102005957 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 360102005958 YniB-like protein; Region: YniB; pfam14002 360102005959 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 360102005960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102005961 motif II; other site 360102005962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102005963 MULE transposase domain; Region: MULE; pfam10551 360102005964 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 360102005965 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 360102005966 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 360102005967 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 360102005968 NADP binding site [chemical binding]; other site 360102005969 homodimer interface [polypeptide binding]; other site 360102005970 active site 360102005971 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 360102005972 transposase/IS protein; Provisional; Region: PRK09183 360102005973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102005974 Walker A motif; other site 360102005975 ATP binding site [chemical binding]; other site 360102005976 Walker B motif; other site 360102005977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102005978 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102005979 DNA-binding interface [nucleotide binding]; DNA binding site 360102005980 Integrase core domain; Region: rve; pfam00665 360102005981 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 360102005982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102005983 dimer interface [polypeptide binding]; other site 360102005984 conserved gate region; other site 360102005985 putative PBP binding loops; other site 360102005986 ABC-ATPase subunit interface; other site 360102005987 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360102005988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102005989 dimer interface [polypeptide binding]; other site 360102005990 conserved gate region; other site 360102005991 putative PBP binding loops; other site 360102005992 ABC-ATPase subunit interface; other site 360102005993 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 360102005994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102005995 Walker A/P-loop; other site 360102005996 ATP binding site [chemical binding]; other site 360102005997 Q-loop/lid; other site 360102005998 ABC transporter signature motif; other site 360102005999 Walker B; other site 360102006000 D-loop; other site 360102006001 H-loop/switch region; other site 360102006002 TOBE domain; Region: TOBE_2; pfam08402 360102006003 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360102006004 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 360102006005 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 360102006006 inner membrane protein; Provisional; Region: PRK11648 360102006007 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 360102006008 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 360102006009 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 360102006010 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 360102006011 amidase catalytic site [active] 360102006012 Zn binding residues [ion binding]; other site 360102006013 substrate binding site [chemical binding]; other site 360102006014 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 360102006015 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 360102006016 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360102006017 dimerization interface [polypeptide binding]; other site 360102006018 putative Zn2+ binding site [ion binding]; other site 360102006019 putative DNA binding site [nucleotide binding]; other site 360102006020 Bacterial transcriptional regulator; Region: IclR; pfam01614 360102006021 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 360102006022 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 360102006023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102006024 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360102006025 putative substrate translocation pore; other site 360102006026 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 360102006027 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102006028 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 360102006029 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 360102006030 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 360102006031 PapC N-terminal domain; Region: PapC_N; pfam13954 360102006032 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102006033 PapC C-terminal domain; Region: PapC_C; pfam13953 360102006034 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 360102006035 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102006036 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 360102006037 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 360102006038 heat shock protein HtpX; Provisional; Region: PRK05457 360102006039 carboxy-terminal protease; Provisional; Region: PRK11186 360102006040 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 360102006041 protein binding site [polypeptide binding]; other site 360102006042 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 360102006043 Catalytic dyad [active] 360102006044 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 360102006045 ProP expression regulator; Provisional; Region: PRK04950 360102006046 ProQ/FINO family; Region: ProQ; pfam04352 360102006047 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 360102006048 GAF domain; Region: GAF_2; pfam13185 360102006049 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 360102006050 Paraquat-inducible protein A; Region: PqiA; pfam04403 360102006051 Paraquat-inducible protein A; Region: PqiA; pfam04403 360102006052 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 360102006053 mce related protein; Region: MCE; pfam02470 360102006054 mce related protein; Region: MCE; pfam02470 360102006055 mce related protein; Region: MCE; pfam02470 360102006056 mce related protein; Region: MCE; pfam02470 360102006057 mce related protein; Region: MCE; pfam02470 360102006058 mce related protein; Region: MCE; pfam02470 360102006059 Uncharacterized secreted protein [Function unknown]; Region: COG5430 360102006060 Uncharacterized secreted protein [Function unknown]; Region: COG5430 360102006061 Uncharacterized secreted protein [Function unknown]; Region: COG5430 360102006062 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 360102006063 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102006064 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 360102006065 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102006066 PapC C-terminal domain; Region: PapC_C; pfam13953 360102006067 Spore Coat Protein U domain; Region: SCPU; pfam05229 360102006068 Uncharacterized secreted protein [Function unknown]; Region: COG5430 360102006069 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 360102006070 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 360102006071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102006072 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102006073 DNA-binding interface [nucleotide binding]; DNA binding site 360102006074 Integrase core domain; Region: rve; pfam00665 360102006075 transposase/IS protein; Provisional; Region: PRK09183 360102006076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102006077 Walker A motif; other site 360102006078 ATP binding site [chemical binding]; other site 360102006079 Walker B motif; other site 360102006080 Patatin-like phospholipase; Region: Patatin; pfam01734 360102006081 nucleophile elbow; other site 360102006082 Lipase; Region: Lipase; pfam00151 360102006083 alanine racemase; Reviewed; Region: PRK13340 360102006084 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826 360102006085 active site 360102006086 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360102006087 dimer interface [polypeptide binding]; other site 360102006088 substrate binding site [chemical binding]; other site 360102006089 catalytic residues [active] 360102006090 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 360102006091 YadA-like C-terminal region; Region: YadA; pfam03895 360102006092 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 360102006093 Haemagglutinin; Region: HIM; pfam05662 360102006094 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 360102006095 trimer interface [polypeptide binding]; other site 360102006096 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 360102006097 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 360102006098 amidase catalytic site [active] 360102006099 Zn binding residues [ion binding]; other site 360102006100 substrate binding site [chemical binding]; other site 360102006101 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 360102006102 chemotaxis regulator CheZ; Provisional; Region: PRK11166 360102006103 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 360102006104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102006105 active site 360102006106 phosphorylation site [posttranslational modification] 360102006107 intermolecular recognition site; other site 360102006108 dimerization interface [polypeptide binding]; other site 360102006109 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 360102006110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102006111 active site 360102006112 phosphorylation site [posttranslational modification] 360102006113 intermolecular recognition site; other site 360102006114 dimerization interface [polypeptide binding]; other site 360102006115 CheB methylesterase; Region: CheB_methylest; pfam01339 360102006116 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 360102006117 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 360102006118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102006119 methyl-accepting protein IV; Provisional; Region: PRK09793 360102006120 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 360102006121 dimer interface [polypeptide binding]; other site 360102006122 ligand binding site [chemical binding]; other site 360102006123 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102006124 dimerization interface [polypeptide binding]; other site 360102006125 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360102006126 dimer interface [polypeptide binding]; other site 360102006127 putative CheW interface [polypeptide binding]; other site 360102006128 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 360102006129 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 360102006130 dimer interface [polypeptide binding]; other site 360102006131 ligand binding site [chemical binding]; other site 360102006132 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102006133 dimerization interface [polypeptide binding]; other site 360102006134 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360102006135 dimer interface [polypeptide binding]; other site 360102006136 putative CheW interface [polypeptide binding]; other site 360102006137 hypothetical protein; Provisional; Region: PRK10215 360102006138 Predicted membrane protein [Function unknown]; Region: COG5373 360102006139 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 360102006140 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 360102006141 Autotransporter beta-domain; Region: Autotransporter; smart00869 360102006142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 360102006143 YheO-like PAS domain; Region: PAS_6; pfam08348 360102006144 HTH domain; Region: HTH_22; pfam13309 360102006145 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 360102006146 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 360102006147 homotrimer interaction site [polypeptide binding]; other site 360102006148 putative active site [active] 360102006149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102006150 putative substrate translocation pore; other site 360102006151 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 360102006152 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 360102006153 putative CheA interaction surface; other site 360102006154 chemotaxis protein CheA; Provisional; Region: PRK10547 360102006155 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 360102006156 putative binding surface; other site 360102006157 active site 360102006158 CheY binding; Region: CheY-binding; pfam09078 360102006159 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 360102006160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102006161 ATP binding site [chemical binding]; other site 360102006162 Mg2+ binding site [ion binding]; other site 360102006163 G-X-G motif; other site 360102006164 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 360102006165 flagellar motor protein MotB; Reviewed; Region: motB; PRK12799 360102006166 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 360102006167 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360102006168 ligand binding site [chemical binding]; other site 360102006169 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 360102006170 flagellar motor protein MotA; Validated; Region: PRK09110 360102006171 transcriptional activator FlhC; Provisional; Region: PRK12722 360102006172 transcriptional activator FlhD; Provisional; Region: PRK02909 360102006173 magnesium-transporting ATPase; Provisional; Region: PRK15122 360102006174 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 360102006175 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360102006176 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 360102006177 Soluble P-type ATPase [General function prediction only]; Region: COG4087 360102006178 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 360102006179 magnesium transport protein MgtC; Provisional; Region: PRK15385 360102006180 MgtC family; Region: MgtC; pfam02308 360102006181 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 360102006182 dimer interface [polypeptide binding]; other site 360102006183 ligand binding site [chemical binding]; other site 360102006184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102006185 dimerization interface [polypeptide binding]; other site 360102006186 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360102006187 dimer interface [polypeptide binding]; other site 360102006188 putative CheW interface [polypeptide binding]; other site 360102006189 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360102006190 hypothetical protein; Provisional; Region: PRK10708 360102006191 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 360102006192 DNA-binding site [nucleotide binding]; DNA binding site 360102006193 RNA-binding motif; other site 360102006194 transposase/IS protein; Provisional; Region: PRK09183 360102006195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102006196 Walker A motif; other site 360102006197 ATP binding site [chemical binding]; other site 360102006198 Walker B motif; other site 360102006199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102006200 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102006201 DNA-binding interface [nucleotide binding]; DNA binding site 360102006202 Integrase core domain; Region: rve; pfam00665 360102006203 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 360102006204 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 360102006205 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 360102006206 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 360102006207 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 360102006208 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 360102006209 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 360102006210 NAD(P) binding site [chemical binding]; other site 360102006211 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 360102006212 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 360102006213 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 360102006214 putative DNA binding site [nucleotide binding]; other site 360102006215 putative Zn2+ binding site [ion binding]; other site 360102006216 AsnC family; Region: AsnC_trans_reg; pfam01037 360102006217 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 360102006218 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 360102006219 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 360102006220 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 360102006221 catalytic core [active] 360102006222 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 360102006223 Predicted transcriptional regulators [Transcription]; Region: COG1733 360102006224 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 360102006225 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 360102006226 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 360102006227 NADP binding site [chemical binding]; other site 360102006228 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360102006229 PAS domain; Region: PAS_9; pfam13426 360102006230 putative active site [active] 360102006231 heme pocket [chemical binding]; other site 360102006232 HAMP domain; Region: HAMP; pfam00672 360102006233 dimerization interface [polypeptide binding]; other site 360102006234 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360102006235 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360102006236 dimer interface [polypeptide binding]; other site 360102006237 putative CheW interface [polypeptide binding]; other site 360102006238 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360102006239 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102006240 DNA binding site [nucleotide binding] 360102006241 domain linker motif; other site 360102006242 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 360102006243 putative dimerization interface [polypeptide binding]; other site 360102006244 putative ligand binding site [chemical binding]; other site 360102006245 isocitrate dehydrogenase; Validated; Region: PRK07362 360102006246 isocitrate dehydrogenase; Reviewed; Region: PRK07006 360102006247 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 360102006248 pseudouridine synthase; Region: TIGR00093 360102006249 probable active site [active] 360102006250 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 360102006251 nudix motif; other site 360102006252 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 360102006253 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 360102006254 putative lysogenization regulator; Reviewed; Region: PRK00218 360102006255 adenylosuccinate lyase; Provisional; Region: PRK09285 360102006256 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 360102006257 tetramer interface [polypeptide binding]; other site 360102006258 active site 360102006259 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 360102006260 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 360102006261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102006262 active site 360102006263 phosphorylation site [posttranslational modification] 360102006264 intermolecular recognition site; other site 360102006265 dimerization interface [polypeptide binding]; other site 360102006266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102006267 DNA binding site [nucleotide binding] 360102006268 sensor protein PhoQ; Provisional; Region: PRK10815 360102006269 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 360102006270 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 360102006271 dimer interface [polypeptide binding]; other site 360102006272 phosphorylation site [posttranslational modification] 360102006273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102006274 ATP binding site [chemical binding]; other site 360102006275 Mg2+ binding site [ion binding]; other site 360102006276 G-X-G motif; other site 360102006277 Uncharacterized conserved protein [Function unknown]; Region: COG2850 360102006278 Cupin-like domain; Region: Cupin_8; pfam13621 360102006279 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 360102006280 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 360102006281 metal binding site [ion binding]; metal-binding site 360102006282 dimer interface [polypeptide binding]; other site 360102006283 NAD-dependent deacetylase; Provisional; Region: PRK00481 360102006284 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 360102006285 NAD+ binding site [chemical binding]; other site 360102006286 substrate binding site [chemical binding]; other site 360102006287 Zn binding site [ion binding]; other site 360102006288 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 360102006289 fructokinase; Reviewed; Region: PRK09557 360102006290 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360102006291 nucleotide binding site [chemical binding]; other site 360102006292 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 360102006293 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 360102006294 FtsX-like permease family; Region: FtsX; pfam02687 360102006295 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 360102006296 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 360102006297 Walker A/P-loop; other site 360102006298 ATP binding site [chemical binding]; other site 360102006299 Q-loop/lid; other site 360102006300 ABC transporter signature motif; other site 360102006301 Walker B; other site 360102006302 D-loop; other site 360102006303 H-loop/switch region; other site 360102006304 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 360102006305 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 360102006306 FtsX-like permease family; Region: FtsX; pfam02687 360102006307 transcription-repair coupling factor; Provisional; Region: PRK10689 360102006308 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 360102006309 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360102006310 ATP binding site [chemical binding]; other site 360102006311 putative Mg++ binding site [ion binding]; other site 360102006312 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102006313 nucleotide binding region [chemical binding]; other site 360102006314 ATP-binding site [chemical binding]; other site 360102006315 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 360102006316 hypothetical protein; Provisional; Region: PRK11280 360102006317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102006318 MULE transposase domain; Region: MULE; pfam10551 360102006319 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 360102006320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360102006321 hypothetical protein; Provisional; Region: PRK04940 360102006322 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 360102006323 beta-hexosaminidase; Provisional; Region: PRK05337 360102006324 thiamine kinase; Region: ycfN_thiK; TIGR02721 360102006325 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 360102006326 active site 360102006327 substrate binding site [chemical binding]; other site 360102006328 ATP binding site [chemical binding]; other site 360102006329 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 360102006330 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 360102006331 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 360102006332 putative dimer interface [polypeptide binding]; other site 360102006333 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 360102006334 nucleotide binding site/active site [active] 360102006335 HIT family signature motif; other site 360102006336 catalytic residue [active] 360102006337 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 360102006338 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 360102006339 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 360102006340 shikimate binding site; other site 360102006341 NAD(P) binding site [chemical binding]; other site 360102006342 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 360102006343 transposase/IS protein; Provisional; Region: PRK09183 360102006344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102006345 Walker A motif; other site 360102006346 ATP binding site [chemical binding]; other site 360102006347 Walker B motif; other site 360102006348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102006349 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102006350 DNA-binding interface [nucleotide binding]; DNA binding site 360102006351 Integrase core domain; Region: rve; pfam00665 360102006352 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102006353 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 360102006354 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360102006355 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360102006356 active site turn [active] 360102006357 phosphorylation site [posttranslational modification] 360102006358 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 360102006359 active site 360102006360 DNA polymerase III subunit delta'; Validated; Region: PRK07993 360102006361 DNA polymerase III subunit delta'; Validated; Region: PRK08485 360102006362 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 360102006363 thymidylate kinase; Validated; Region: tmk; PRK00698 360102006364 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 360102006365 TMP-binding site; other site 360102006366 ATP-binding site [chemical binding]; other site 360102006367 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 360102006368 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 360102006369 dimerization interface [polypeptide binding]; other site 360102006370 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 360102006371 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 360102006372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102006373 catalytic residue [active] 360102006374 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102006375 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 360102006376 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 360102006377 dimer interface [polypeptide binding]; other site 360102006378 active site 360102006379 acyl carrier protein; Provisional; Region: acpP; PRK00982 360102006380 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 360102006381 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 360102006382 NAD(P) binding site [chemical binding]; other site 360102006383 homotetramer interface [polypeptide binding]; other site 360102006384 homodimer interface [polypeptide binding]; other site 360102006385 active site 360102006386 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 360102006387 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 360102006388 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 360102006389 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 360102006390 dimer interface [polypeptide binding]; other site 360102006391 active site 360102006392 CoA binding pocket [chemical binding]; other site 360102006393 Fatty acid/phospholipid biosynthesis enzyme [Lipid metabolism]; Region: PlsX; COG0416 360102006394 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 360102006395 hypothetical protein; Provisional; Region: PRK11193 360102006396 Maf-like protein; Region: Maf; pfam02545 360102006397 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 360102006398 active site 360102006399 dimer interface [polypeptide binding]; other site 360102006400 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102006401 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 360102006402 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360102006403 RNA binding surface [nucleotide binding]; other site 360102006404 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 360102006405 active site 360102006406 YPA_r054; 5' UTR element of RNase E gene 360102006407 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 360102006408 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 360102006409 homodimer interface [polypeptide binding]; other site 360102006410 oligonucleotide binding site [chemical binding]; other site 360102006411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102006412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102006413 MULE transposase domain; Region: MULE; pfam10551 360102006414 Integrase core domain; Region: rve_3; cl15866 360102006415 Uncharacterized conserved protein [Function unknown]; Region: COG1359 360102006416 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 360102006417 active site 360102006418 substrate binding pocket [chemical binding]; other site 360102006419 dimer interface [polypeptide binding]; other site 360102006420 DNA damage-inducible protein I; Provisional; Region: PRK10597 360102006421 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 360102006422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102006423 MULE transposase domain; Region: MULE; pfam10551 360102006424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102006425 MULE transposase domain; Region: MULE; pfam10551 360102006426 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 360102006427 hydroxyglutarate oxidase; Provisional; Region: PRK11728 360102006428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102006429 MULE transposase domain; Region: MULE; pfam10551 360102006430 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102006431 DNA binding residues [nucleotide binding] 360102006432 dimerization interface [polypeptide binding]; other site 360102006433 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 360102006434 Domain of unknown function DUF20; Region: UPF0118; pfam01594 360102006435 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 360102006436 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 360102006437 active site residue [active] 360102006438 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 360102006439 EamA-like transporter family; Region: EamA; pfam00892 360102006440 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 360102006441 Autoinducer synthetase; Region: Autoind_synth; pfam00765 360102006442 Autoinducer binding domain; Region: Autoind_bind; pfam03472 360102006443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102006444 DNA binding residues [nucleotide binding] 360102006445 dimerization interface [polypeptide binding]; other site 360102006446 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 360102006447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102006448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360102006449 dimerization interface [polypeptide binding]; other site 360102006450 benzoate transport; Region: 2A0115; TIGR00895 360102006451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102006452 putative substrate translocation pore; other site 360102006453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102006454 Formaldehyde-activating enzyme nesessary for methanogenesis [Energy production and conversion]; Region: COG1795 360102006455 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360102006456 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360102006457 active site 360102006458 catalytic tetrad [active] 360102006459 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09674 360102006460 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 360102006461 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09676 360102006462 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09675 360102006463 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 360102006464 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 360102006465 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 360102006466 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 360102006467 Mechanosensitive ion channel; Region: MS_channel; pfam00924 360102006468 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 360102006469 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 360102006470 active site 360102006471 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360102006472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102006473 dimer interface [polypeptide binding]; other site 360102006474 conserved gate region; other site 360102006475 putative PBP binding loops; other site 360102006476 ABC-ATPase subunit interface; other site 360102006477 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 360102006478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102006479 dimer interface [polypeptide binding]; other site 360102006480 putative PBP binding loops; other site 360102006481 ABC-ATPase subunit interface; other site 360102006482 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360102006483 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 360102006484 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360102006485 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102006486 DNA binding site [nucleotide binding] 360102006487 domain linker motif; other site 360102006488 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 360102006489 putative dimerization interface [polypeptide binding]; other site 360102006490 putative ligand binding site [chemical binding]; other site 360102006491 phosphomannomutase CpsG; Provisional; Region: PRK15414 360102006492 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 360102006493 active site 360102006494 substrate binding site [chemical binding]; other site 360102006495 metal binding site [ion binding]; metal-binding site 360102006496 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 360102006497 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 360102006498 Walker A/P-loop; other site 360102006499 ATP binding site [chemical binding]; other site 360102006500 Q-loop/lid; other site 360102006501 ABC transporter signature motif; other site 360102006502 Walker B; other site 360102006503 D-loop; other site 360102006504 H-loop/switch region; other site 360102006505 TOBE domain; Region: TOBE_2; pfam08402 360102006506 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 360102006507 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 360102006508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4304 360102006509 haemagglutination activity domain; Region: Haemagg_act; pfam05860 360102006510 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 360102006511 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102006512 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102006513 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102006514 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 360102006515 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 360102006516 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 360102006517 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 360102006518 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 360102006519 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 360102006520 FMN-binding pocket [chemical binding]; other site 360102006521 flavin binding motif; other site 360102006522 phosphate binding motif [ion binding]; other site 360102006523 beta-alpha-beta structure motif; other site 360102006524 NAD binding pocket [chemical binding]; other site 360102006525 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 360102006526 catalytic loop [active] 360102006527 iron binding site [ion binding]; other site 360102006528 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 360102006529 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 360102006530 [2Fe-2S] cluster binding site [ion binding]; other site 360102006531 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 360102006532 putative alpha subunit interface [polypeptide binding]; other site 360102006533 putative active site [active] 360102006534 putative substrate binding site [chemical binding]; other site 360102006535 Fe binding site [ion binding]; other site 360102006536 putative transporter; Provisional; Region: PRK09950 360102006537 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 360102006538 tartrate dehydrogenase; Region: TTC; TIGR02089 360102006539 transcriptional activator TtdR; Provisional; Region: PRK09801 360102006540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102006541 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 360102006542 putative effector binding pocket; other site 360102006543 putative dimerization interface [polypeptide binding]; other site 360102006544 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360102006545 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102006546 DNA binding site [nucleotide binding] 360102006547 domain linker motif; other site 360102006548 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 360102006549 dimerization interface [polypeptide binding]; other site 360102006550 ligand binding site [chemical binding]; other site 360102006551 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102006552 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102006553 TM-ABC transporter signature motif; other site 360102006554 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360102006555 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102006556 Walker A/P-loop; other site 360102006557 ATP binding site [chemical binding]; other site 360102006558 Q-loop/lid; other site 360102006559 ABC transporter signature motif; other site 360102006560 Walker B; other site 360102006561 D-loop; other site 360102006562 H-loop/switch region; other site 360102006563 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102006564 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 360102006565 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 360102006566 putative ligand binding site [chemical binding]; other site 360102006567 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 360102006568 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 360102006569 NAD(P) binding site [chemical binding]; other site 360102006570 threonine and homoserine efflux system; Provisional; Region: PRK10532 360102006571 putative acetyltransferase YhhY; Provisional; Region: PRK10140 360102006572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360102006573 Coenzyme A binding pocket [chemical binding]; other site 360102006574 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 360102006575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102006576 S-adenosylmethionine binding site [chemical binding]; other site 360102006577 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 360102006578 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 360102006579 dimerization interface [polypeptide binding]; other site 360102006580 DPS ferroxidase diiron center [ion binding]; other site 360102006581 ion pore; other site 360102006582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360102006583 TPR motif; other site 360102006584 binding surface 360102006585 Uncharacterized conserved protein [Function unknown]; Region: COG1434 360102006586 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 360102006587 putative active site [active] 360102006588 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 360102006589 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102006590 substrate binding pocket [chemical binding]; other site 360102006591 membrane-bound complex binding site; other site 360102006592 hinge residues; other site 360102006593 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360102006594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102006595 dimer interface [polypeptide binding]; other site 360102006596 conserved gate region; other site 360102006597 putative PBP binding loops; other site 360102006598 ABC-ATPase subunit interface; other site 360102006599 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 360102006600 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 360102006601 Walker A/P-loop; other site 360102006602 ATP binding site [chemical binding]; other site 360102006603 Q-loop/lid; other site 360102006604 ABC transporter signature motif; other site 360102006605 Walker B; other site 360102006606 D-loop; other site 360102006607 H-loop/switch region; other site 360102006608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360102006609 PAS domain; Region: PAS_9; pfam13426 360102006610 putative active site [active] 360102006611 heme pocket [chemical binding]; other site 360102006612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360102006613 PAS domain; Region: PAS_9; pfam13426 360102006614 putative active site [active] 360102006615 heme pocket [chemical binding]; other site 360102006616 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360102006617 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 360102006618 dimer interface [polypeptide binding]; other site 360102006619 putative CheW interface [polypeptide binding]; other site 360102006620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102006621 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102006622 DNA-binding interface [nucleotide binding]; DNA binding site 360102006623 Integrase core domain; Region: rve; pfam00665 360102006624 transposase/IS protein; Provisional; Region: PRK09183 360102006625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102006626 Walker A motif; other site 360102006627 ATP binding site [chemical binding]; other site 360102006628 Walker B motif; other site 360102006629 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 360102006630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102006631 S-adenosylmethionine binding site [chemical binding]; other site 360102006632 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 360102006633 glycosyl transferase family protein; Provisional; Region: PRK08136 360102006634 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 360102006635 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 360102006636 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 360102006637 acyl-activating enzyme (AAE) consensus motif; other site 360102006638 putative AMP binding site [chemical binding]; other site 360102006639 putative active site [active] 360102006640 putative CoA binding site [chemical binding]; other site 360102006641 O-succinylbenzoate synthase; Provisional; Region: PRK05105 360102006642 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 360102006643 active site 360102006644 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 360102006645 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 360102006646 substrate binding site [chemical binding]; other site 360102006647 oxyanion hole (OAH) forming residues; other site 360102006648 trimer interface [polypeptide binding]; other site 360102006649 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 360102006650 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 360102006651 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 360102006652 dimer interface [polypeptide binding]; other site 360102006653 tetramer interface [polypeptide binding]; other site 360102006654 PYR/PP interface [polypeptide binding]; other site 360102006655 TPP binding site [chemical binding]; other site 360102006656 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 360102006657 TPP-binding site; other site 360102006658 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 360102006659 chorismate binding enzyme; Region: Chorismate_bind; cl10555 360102006660 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 360102006661 phosphogluconate dehydratase; Validated; Region: PRK09054 360102006662 6-phosphogluconate dehydratase; Region: edd; TIGR01196 360102006663 Uncharacterized conserved protein [Function unknown]; Region: COG4702 360102006664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102006665 D-galactonate transporter; Region: 2A0114; TIGR00893 360102006666 putative substrate translocation pore; other site 360102006667 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 360102006668 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 360102006669 putative ligand binding site [chemical binding]; other site 360102006670 NAD binding site [chemical binding]; other site 360102006671 catalytic site [active] 360102006672 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 360102006673 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102006674 DNA binding site [nucleotide binding] 360102006675 domain linker motif; other site 360102006676 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 360102006677 putative ligand binding site [chemical binding]; other site 360102006678 putative dimerization interface [polypeptide binding]; other site 360102006679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 360102006680 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 360102006681 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 360102006682 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 360102006683 NADP binding site [chemical binding]; other site 360102006684 homodimer interface [polypeptide binding]; other site 360102006685 active site 360102006686 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 360102006687 AAA domain; Region: AAA_33; pfam13671 360102006688 ATP-binding site [chemical binding]; other site 360102006689 Gluconate-6-phosphate binding site [chemical binding]; other site 360102006690 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 360102006691 RNA polymerase I-specific transcription-initiation factor; Region: Rrn6; pfam10214 360102006692 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 360102006693 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 360102006694 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 360102006695 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 360102006696 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 360102006697 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 360102006698 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 360102006699 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 360102006700 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 360102006701 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 360102006702 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 360102006703 4Fe-4S binding domain; Region: Fer4; pfam00037 360102006704 4Fe-4S binding domain; Region: Fer4; pfam00037 360102006705 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 360102006706 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 360102006707 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 360102006708 catalytic loop [active] 360102006709 iron binding site [ion binding]; other site 360102006710 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 360102006711 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 360102006712 [4Fe-4S] binding site [ion binding]; other site 360102006713 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 360102006714 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 360102006715 SLBB domain; Region: SLBB; pfam10531 360102006716 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 360102006717 NADH dehydrogenase subunit E; Validated; Region: PRK07539 360102006718 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 360102006719 putative dimer interface [polypeptide binding]; other site 360102006720 [2Fe-2S] cluster binding site [ion binding]; other site 360102006721 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 360102006722 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 360102006723 NADH dehydrogenase subunit D; Validated; Region: PRK06075 360102006724 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 360102006725 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 360102006726 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 360102006727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102006728 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 360102006729 putative dimerization interface [polypeptide binding]; other site 360102006730 aminotransferase AlaT; Validated; Region: PRK09265 360102006731 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360102006732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102006733 homodimer interface [polypeptide binding]; other site 360102006734 catalytic residue [active] 360102006735 5'-nucleotidase; Provisional; Region: PRK03826 360102006736 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 360102006737 transmembrane helices; other site 360102006738 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 360102006739 TrkA-C domain; Region: TrkA_C; pfam02080 360102006740 TrkA-C domain; Region: TrkA_C; pfam02080 360102006741 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 360102006742 putative phosphatase; Provisional; Region: PRK11587 360102006743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102006744 motif II; other site 360102006745 hypothetical protein; Validated; Region: PRK05445 360102006746 hypothetical protein; Provisional; Region: PRK01816 360102006747 propionate/acetate kinase; Provisional; Region: PRK12379 360102006748 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 360102006749 phosphate acetyltransferase; Reviewed; Region: PRK05632 360102006750 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 360102006751 DRTGG domain; Region: DRTGG; pfam07085 360102006752 phosphate acetyltransferase; Region: pta; TIGR00651 360102006753 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360102006754 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102006755 DNA binding site [nucleotide binding] 360102006756 domain linker motif; other site 360102006757 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 360102006758 putative dimerization interface [polypeptide binding]; other site 360102006759 putative ligand binding site [chemical binding]; other site 360102006760 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 360102006761 active site 360102006762 phosphorylation site [posttranslational modification] 360102006763 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 360102006764 active site 360102006765 P-loop; other site 360102006766 phosphorylation site [posttranslational modification] 360102006767 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 360102006768 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 360102006769 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 360102006770 nudix motif; other site 360102006771 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 360102006772 active site 360102006773 metal binding site [ion binding]; metal-binding site 360102006774 homotetramer interface [polypeptide binding]; other site 360102006775 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360102006776 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 360102006777 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 360102006778 putative NAD(P) binding site [chemical binding]; other site 360102006779 putative active site [active] 360102006780 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 360102006781 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 360102006782 Walker A/P-loop; other site 360102006783 ATP binding site [chemical binding]; other site 360102006784 Q-loop/lid; other site 360102006785 ABC transporter signature motif; other site 360102006786 Walker B; other site 360102006787 D-loop; other site 360102006788 H-loop/switch region; other site 360102006789 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360102006790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102006791 dimer interface [polypeptide binding]; other site 360102006792 conserved gate region; other site 360102006793 putative PBP binding loops; other site 360102006794 ABC-ATPase subunit interface; other site 360102006795 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360102006796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102006797 dimer interface [polypeptide binding]; other site 360102006798 conserved gate region; other site 360102006799 putative PBP binding loops; other site 360102006800 ABC-ATPase subunit interface; other site 360102006801 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 360102006802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102006803 substrate binding pocket [chemical binding]; other site 360102006804 membrane-bound complex binding site; other site 360102006805 hinge residues; other site 360102006806 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102006807 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102006808 DNA-binding interface [nucleotide binding]; DNA binding site 360102006809 Integrase core domain; Region: rve; pfam00665 360102006810 transposase/IS protein; Provisional; Region: PRK09183 360102006811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102006812 Walker A motif; other site 360102006813 ATP binding site [chemical binding]; other site 360102006814 Walker B motif; other site 360102006815 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 360102006816 Flavoprotein; Region: Flavoprotein; pfam02441 360102006817 amidophosphoribosyltransferase; Provisional; Region: PRK09246 360102006818 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 360102006819 active site 360102006820 tetramer interface [polypeptide binding]; other site 360102006821 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360102006822 active site 360102006823 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 360102006824 colicin V production protein; Provisional; Region: PRK10845 360102006825 cell division protein DedD; Provisional; Region: PRK11633 360102006826 Sporulation related domain; Region: SPOR; pfam05036 360102006827 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 360102006828 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360102006829 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 360102006830 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 360102006831 hypothetical protein; Provisional; Region: PRK10847 360102006832 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360102006833 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 360102006834 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 360102006835 dimerization interface 3.5A [polypeptide binding]; other site 360102006836 active site 360102006837 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 360102006838 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 360102006839 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 360102006840 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 360102006841 ligand binding site [chemical binding]; other site 360102006842 NAD binding site [chemical binding]; other site 360102006843 catalytic site [active] 360102006844 homodimer interface [polypeptide binding]; other site 360102006845 Cupin domain; Region: Cupin_2; pfam07883 360102006846 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 360102006847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102006848 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 360102006849 EamA-like transporter family; Region: EamA; pfam00892 360102006850 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 360102006851 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 360102006852 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 360102006853 aspartate racemase; Region: asp_race; TIGR00035 360102006854 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 360102006855 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 360102006856 dimer interface [polypeptide binding]; other site 360102006857 active site 360102006858 Uncharacterized conserved protein [Function unknown]; Region: COG4121 360102006859 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 360102006860 hydroxyglutarate oxidase; Provisional; Region: PRK11728 360102006861 YfcL protein; Region: YfcL; pfam08891 360102006862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 360102006863 hypothetical protein; Provisional; Region: PRK10621 360102006864 Predicted permeases [General function prediction only]; Region: COG0730 360102006865 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 360102006866 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 360102006867 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 360102006868 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 360102006869 Tetramer interface [polypeptide binding]; other site 360102006870 active site 360102006871 FMN-binding site [chemical binding]; other site 360102006872 HemK family putative methylases; Region: hemK_fam; TIGR00536 360102006873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102006874 S-adenosylmethionine binding site [chemical binding]; other site 360102006875 hypothetical protein; Provisional; Region: PRK04946 360102006876 Smr domain; Region: Smr; pfam01713 360102006877 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 360102006878 catalytic core [active] 360102006879 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 360102006880 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 360102006881 substrate binding site [chemical binding]; other site 360102006882 oxyanion hole (OAH) forming residues; other site 360102006883 trimer interface [polypeptide binding]; other site 360102006884 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 360102006885 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 360102006886 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 360102006887 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 360102006888 dimer interface [polypeptide binding]; other site 360102006889 active site 360102006890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 360102006891 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 360102006892 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 360102006893 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 360102006894 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 360102006895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360102006896 binding surface 360102006897 TPR motif; other site 360102006898 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 360102006899 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 360102006900 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 360102006901 catalytic residues [active] 360102006902 central insert; other site 360102006903 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 360102006904 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 360102006905 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 360102006906 heme exporter protein CcmC; Region: ccmC; TIGR01191 360102006907 heme exporter protein CcmB; Region: ccmB; TIGR01190 360102006908 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 360102006909 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 360102006910 Walker A/P-loop; other site 360102006911 ATP binding site [chemical binding]; other site 360102006912 Q-loop/lid; other site 360102006913 ABC transporter signature motif; other site 360102006914 Walker B; other site 360102006915 D-loop; other site 360102006916 H-loop/switch region; other site 360102006917 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 360102006918 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 360102006919 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 360102006920 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 360102006921 PhnA protein; Region: PhnA; pfam03831 360102006922 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 360102006923 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 360102006924 ImpE protein; Region: ImpE; pfam07024 360102006925 PAAR motif; Region: PAAR_motif; pfam05488 360102006926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 360102006927 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 360102006928 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 360102006929 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 360102006930 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 360102006931 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 360102006932 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 360102006933 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360102006934 ligand binding site [chemical binding]; other site 360102006935 transposase/IS protein; Provisional; Region: PRK09183 360102006936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102006937 Walker A motif; other site 360102006938 ATP binding site [chemical binding]; other site 360102006939 Walker B motif; other site 360102006940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102006941 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102006942 DNA-binding interface [nucleotide binding]; DNA binding site 360102006943 Integrase core domain; Region: rve; pfam00665 360102006944 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 360102006945 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 360102006946 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 360102006947 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 360102006948 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 360102006949 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 360102006950 Protein of unknown function (DUF877); Region: DUF877; pfam05943 360102006951 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 360102006952 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 360102006953 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 360102006954 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102006955 PapC C-terminal domain; Region: PapC_C; pfam13953 360102006956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102006957 MULE transposase domain; Region: MULE; pfam10551 360102006958 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 360102006959 PapC N-terminal domain; Region: PapC_N; pfam13954 360102006960 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102006961 putative chaperone protein EcpD; Provisional; Region: PRK09926 360102006962 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102006963 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 360102006964 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 360102006965 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 360102006966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102006967 Walker A motif; other site 360102006968 ATP binding site [chemical binding]; other site 360102006969 Walker B motif; other site 360102006970 arginine finger; other site 360102006971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102006972 Walker A motif; other site 360102006973 ATP binding site [chemical binding]; other site 360102006974 Walker B motif; other site 360102006975 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 360102006976 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 360102006977 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 360102006978 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 360102006979 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 360102006980 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 360102006981 Fimbrial protein; Region: Fimbrial; pfam00419 360102006982 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 360102006983 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 360102006984 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360102006985 ligand binding site [chemical binding]; other site 360102006986 Uncharacterized conserved protein [Function unknown]; Region: COG5435 360102006987 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 360102006988 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102006989 DNA binding residues [nucleotide binding] 360102006990 dimerization interface [polypeptide binding]; other site 360102006991 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 360102006992 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 360102006993 N-acetyl-D-glucosamine binding site [chemical binding]; other site 360102006994 catalytic residue [active] 360102006995 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 360102006996 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 360102006997 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 360102006998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102006999 dimer interface [polypeptide binding]; other site 360102007000 conserved gate region; other site 360102007001 putative PBP binding loops; other site 360102007002 ABC-ATPase subunit interface; other site 360102007003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007004 dimer interface [polypeptide binding]; other site 360102007005 conserved gate region; other site 360102007006 putative PBP binding loops; other site 360102007007 ABC-ATPase subunit interface; other site 360102007008 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 360102007009 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 360102007010 Walker A/P-loop; other site 360102007011 ATP binding site [chemical binding]; other site 360102007012 Q-loop/lid; other site 360102007013 ABC transporter signature motif; other site 360102007014 Walker B; other site 360102007015 D-loop; other site 360102007016 H-loop/switch region; other site 360102007017 Predicted membrane protein [Function unknown]; Region: COG4331 360102007018 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 360102007019 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 360102007020 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 360102007021 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 360102007022 putative [Fe4-S4] binding site [ion binding]; other site 360102007023 putative molybdopterin cofactor binding site [chemical binding]; other site 360102007024 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 360102007025 putative molybdopterin cofactor binding site; other site 360102007026 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 360102007027 4Fe-4S binding domain; Region: Fer4; cl02805 360102007028 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 360102007029 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 360102007030 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 360102007031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 360102007032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 360102007033 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 360102007034 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 360102007035 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 360102007036 aminotransferase; Validated; Region: PRK08175 360102007037 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360102007038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102007039 homodimer interface [polypeptide binding]; other site 360102007040 catalytic residue [active] 360102007041 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 360102007042 glucokinase, proteobacterial type; Region: glk; TIGR00749 360102007043 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360102007044 nucleotide binding site [chemical binding]; other site 360102007045 Predicted membrane protein [Function unknown]; Region: COG4125 360102007046 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 360102007047 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 360102007048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102007049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102007050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 360102007051 dimerization interface [polypeptide binding]; other site 360102007052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360102007053 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360102007054 active site 360102007055 catalytic tetrad [active] 360102007056 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 360102007057 manganese transport protein MntH; Reviewed; Region: PRK00701 360102007058 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 360102007059 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 360102007060 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 360102007061 Nucleoside recognition; Region: Gate; pfam07670 360102007062 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 360102007063 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 360102007064 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 360102007065 HIGH motif; other site 360102007066 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 360102007067 active site 360102007068 KMSKS motif; other site 360102007069 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102007070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 360102007071 FlxA-like protein; Region: FlxA; pfam14282 360102007072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 360102007073 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 360102007074 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 360102007075 nucleotide binding pocket [chemical binding]; other site 360102007076 K-X-D-G motif; other site 360102007077 catalytic site [active] 360102007078 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 360102007079 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 360102007080 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 360102007081 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 360102007082 Dimer interface [polypeptide binding]; other site 360102007083 BRCT sequence motif; other site 360102007084 cell division protein ZipA; Provisional; Region: PRK03427 360102007085 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 360102007086 FtsZ protein binding site [polypeptide binding]; other site 360102007087 putative sulfate transport protein CysZ; Validated; Region: PRK04949 360102007088 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 360102007089 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 360102007090 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 360102007091 dimer interface [polypeptide binding]; other site 360102007092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102007093 catalytic residue [active] 360102007094 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 360102007095 dimerization domain swap beta strand [polypeptide binding]; other site 360102007096 regulatory protein interface [polypeptide binding]; other site 360102007097 active site 360102007098 regulatory phosphorylation site [posttranslational modification]; other site 360102007099 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 360102007100 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 360102007101 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 360102007102 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 360102007103 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 360102007104 HPr interaction site; other site 360102007105 glycerol kinase (GK) interaction site [polypeptide binding]; other site 360102007106 active site 360102007107 phosphorylation site [posttranslational modification] 360102007108 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102007109 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102007110 dimerization interface [polypeptide binding]; other site 360102007111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102007112 dimer interface [polypeptide binding]; other site 360102007113 phosphorylation site [posttranslational modification] 360102007114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102007115 ATP binding site [chemical binding]; other site 360102007116 Mg2+ binding site [ion binding]; other site 360102007117 G-X-G motif; other site 360102007118 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360102007119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102007120 active site 360102007121 phosphorylation site [posttranslational modification] 360102007122 intermolecular recognition site; other site 360102007123 dimerization interface [polypeptide binding]; other site 360102007124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102007125 DNA binding site [nucleotide binding] 360102007126 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 360102007127 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102007128 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102007129 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 360102007130 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 360102007131 Walker A/P-loop; other site 360102007132 ATP binding site [chemical binding]; other site 360102007133 Q-loop/lid; other site 360102007134 ABC transporter signature motif; other site 360102007135 Walker B; other site 360102007136 D-loop; other site 360102007137 H-loop/switch region; other site 360102007138 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 360102007139 FtsX-like permease family; Region: FtsX; pfam02687 360102007140 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 360102007141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360102007142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360102007143 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360102007144 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 360102007145 active site residue [active] 360102007146 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 360102007147 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 360102007148 Na binding site [ion binding]; other site 360102007149 peptidase; Provisional; Region: PRK15173 360102007150 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 360102007151 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 360102007152 active site 360102007153 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 360102007154 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 360102007155 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360102007156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102007157 homodimer interface [polypeptide binding]; other site 360102007158 catalytic residue [active] 360102007159 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 360102007160 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 360102007161 metal ion-dependent adhesion site (MIDAS); other site 360102007162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360102007163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102007164 dimer interface [polypeptide binding]; other site 360102007165 phosphorylation site [posttranslational modification] 360102007166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102007167 ATP binding site [chemical binding]; other site 360102007168 Mg2+ binding site [ion binding]; other site 360102007169 G-X-G motif; other site 360102007170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360102007171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102007172 active site 360102007173 phosphorylation site [posttranslational modification] 360102007174 intermolecular recognition site; other site 360102007175 dimerization interface [polypeptide binding]; other site 360102007176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102007177 DNA binding site [nucleotide binding] 360102007178 type III secretion protein GogB; Provisional; Region: PRK15386 360102007179 cysteine synthase B; Region: cysM; TIGR01138 360102007180 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 360102007181 dimer interface [polypeptide binding]; other site 360102007182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102007183 catalytic residue [active] 360102007184 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 360102007185 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 360102007186 Walker A/P-loop; other site 360102007187 ATP binding site [chemical binding]; other site 360102007188 Q-loop/lid; other site 360102007189 ABC transporter signature motif; other site 360102007190 Walker B; other site 360102007191 D-loop; other site 360102007192 H-loop/switch region; other site 360102007193 TOBE-like domain; Region: TOBE_3; pfam12857 360102007194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007195 dimer interface [polypeptide binding]; other site 360102007196 conserved gate region; other site 360102007197 putative PBP binding loops; other site 360102007198 ABC-ATPase subunit interface; other site 360102007199 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 360102007200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007201 dimer interface [polypeptide binding]; other site 360102007202 conserved gate region; other site 360102007203 putative PBP binding loops; other site 360102007204 ABC-ATPase subunit interface; other site 360102007205 thiosulfate transporter subunit; Provisional; Region: PRK10852 360102007206 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 360102007207 putative sialic acid transporter; Provisional; Region: PRK03893 360102007208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102007209 putative substrate translocation pore; other site 360102007210 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 360102007211 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 360102007212 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 360102007213 putative active site [active] 360102007214 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 360102007215 N-acetylmannosamine kinase; Provisional; Region: PRK05082 360102007216 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360102007217 nucleotide binding site [chemical binding]; other site 360102007218 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 360102007219 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 360102007220 Leucine rich repeat; Region: LRR_8; pfam13855 360102007221 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 360102007222 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 360102007223 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 360102007224 putative active site cavity [active] 360102007225 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 360102007226 Class I aldolases; Region: Aldolase_Class_I; cl17187 360102007227 catalytic residue [active] 360102007228 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 360102007229 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 360102007230 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 360102007231 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 360102007232 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 360102007233 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 360102007234 Autotransporter beta-domain; Region: Autotransporter; pfam03797 360102007235 putative acetyltransferase; Provisional; Region: PRK03624 360102007236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360102007237 Coenzyme A binding pocket [chemical binding]; other site 360102007238 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 360102007239 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 360102007240 hypothetical protein; Validated; Region: PRK00124 360102007241 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 360102007242 Malic enzyme, N-terminal domain; Region: malic; pfam00390 360102007243 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 360102007244 putative NAD(P) binding site [chemical binding]; other site 360102007245 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 360102007246 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 360102007247 nudix motif; other site 360102007248 active site 360102007249 metal binding site [ion binding]; metal-binding site 360102007250 ADP-ribose binding site [chemical binding]; other site 360102007251 dimer interface [polypeptide binding]; other site 360102007252 transposase/IS protein; Provisional; Region: PRK09183 360102007253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102007254 Walker A motif; other site 360102007255 ATP binding site [chemical binding]; other site 360102007256 Walker B motif; other site 360102007257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102007258 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102007259 DNA-binding interface [nucleotide binding]; DNA binding site 360102007260 Integrase core domain; Region: rve; pfam00665 360102007261 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 360102007262 cytochrome c-type protein NapC; Provisional; Region: PRK10617 360102007263 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 360102007264 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 360102007265 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 360102007266 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 360102007267 [4Fe-4S] binding site [ion binding]; other site 360102007268 molybdopterin cofactor binding site; other site 360102007269 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 360102007270 molybdopterin cofactor binding site; other site 360102007271 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 360102007272 ferredoxin-type protein; Provisional; Region: PRK10194 360102007273 transcriptional regulator NarP; Provisional; Region: PRK10403 360102007274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102007275 active site 360102007276 phosphorylation site [posttranslational modification] 360102007277 intermolecular recognition site; other site 360102007278 dimerization interface [polypeptide binding]; other site 360102007279 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102007280 DNA binding residues [nucleotide binding] 360102007281 dimerization interface [polypeptide binding]; other site 360102007282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4519 360102007283 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 360102007284 Protein export membrane protein; Region: SecD_SecF; cl14618 360102007285 Protein export membrane protein; Region: SecD_SecF; cl14618 360102007286 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 360102007287 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 360102007288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102007289 FeS/SAM binding site; other site 360102007290 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 360102007291 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 360102007292 Sulfatase; Region: Sulfatase; pfam00884 360102007293 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 360102007294 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 360102007295 Walker A/P-loop; other site 360102007296 ATP binding site [chemical binding]; other site 360102007297 Q-loop/lid; other site 360102007298 ABC transporter signature motif; other site 360102007299 Walker B; other site 360102007300 D-loop; other site 360102007301 H-loop/switch region; other site 360102007302 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 360102007303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007304 dimer interface [polypeptide binding]; other site 360102007305 conserved gate region; other site 360102007306 ABC-ATPase subunit interface; other site 360102007307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007308 dimer interface [polypeptide binding]; other site 360102007309 conserved gate region; other site 360102007310 putative PBP binding loops; other site 360102007311 ABC-ATPase subunit interface; other site 360102007312 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 360102007313 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 360102007314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360102007315 TPR motif; other site 360102007316 Tetratrico peptide repeat; Region: TPR_5; pfam12688 360102007317 binding surface 360102007318 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 360102007319 ArsC family; Region: ArsC; pfam03960 360102007320 putative catalytic residues [active] 360102007321 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 360102007322 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 360102007323 metal binding site [ion binding]; metal-binding site 360102007324 dimer interface [polypeptide binding]; other site 360102007325 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 360102007326 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 360102007327 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 360102007328 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 360102007329 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 360102007330 Helicase; Region: Helicase_RecD; pfam05127 360102007331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360102007332 Coenzyme A binding pocket [chemical binding]; other site 360102007333 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 360102007334 Predicted membrane protein [Function unknown]; Region: COG2707 360102007335 Predicted metalloprotease [General function prediction only]; Region: COG2321 360102007336 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 360102007337 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 360102007338 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 360102007339 ATP binding site [chemical binding]; other site 360102007340 active site 360102007341 substrate binding site [chemical binding]; other site 360102007342 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102007343 lipoprotein; Provisional; Region: PRK11679 360102007344 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 360102007345 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 360102007346 dihydrodipicolinate synthase; Region: dapA; TIGR00674 360102007347 dimer interface [polypeptide binding]; other site 360102007348 active site 360102007349 catalytic residue [active] 360102007350 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 360102007351 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 360102007352 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 360102007353 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 360102007354 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 360102007355 catalytic triad [active] 360102007356 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 360102007357 Domain of unknown function DUF20; Region: UPF0118; pfam01594 360102007358 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 360102007359 Peptidase family M48; Region: Peptidase_M48; pfam01435 360102007360 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 360102007361 ArsC family; Region: ArsC; pfam03960 360102007362 catalytic residues [active] 360102007363 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 360102007364 DNA replication initiation factor; Provisional; Region: PRK08084 360102007365 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102007366 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360102007367 active site 360102007368 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 360102007369 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 360102007370 dimerization interface [polypeptide binding]; other site 360102007371 putative ATP binding site [chemical binding]; other site 360102007372 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 360102007373 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 360102007374 active site 360102007375 substrate binding site [chemical binding]; other site 360102007376 cosubstrate binding site; other site 360102007377 catalytic site [active] 360102007378 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 360102007379 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360102007380 Flagellin N-methylase; Region: FliB; pfam03692 360102007381 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 360102007382 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 360102007383 Walker A/P-loop; other site 360102007384 ATP binding site [chemical binding]; other site 360102007385 Q-loop/lid; other site 360102007386 ABC transporter signature motif; other site 360102007387 Walker B; other site 360102007388 D-loop; other site 360102007389 H-loop/switch region; other site 360102007390 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 360102007391 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 360102007392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007393 dimer interface [polypeptide binding]; other site 360102007394 conserved gate region; other site 360102007395 putative PBP binding loops; other site 360102007396 ABC-ATPase subunit interface; other site 360102007397 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 360102007398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007399 conserved gate region; other site 360102007400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007401 dimer interface [polypeptide binding]; other site 360102007402 conserved gate region; other site 360102007403 putative PBP binding loops; other site 360102007404 ABC-ATPase subunit interface; other site 360102007405 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 360102007406 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 360102007407 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 360102007408 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 360102007409 putative active site [active] 360102007410 catalytic site [active] 360102007411 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 360102007412 domain interface [polypeptide binding]; other site 360102007413 active site 360102007414 catalytic site [active] 360102007415 exopolyphosphatase; Provisional; Region: PRK10854 360102007416 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360102007417 nucleotide binding site [chemical binding]; other site 360102007418 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 360102007419 MgtE intracellular N domain; Region: MgtE_N; smart00924 360102007420 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 360102007421 Divalent cation transporter; Region: MgtE; cl00786 360102007422 putative chaperone; Provisional; Region: PRK11678 360102007423 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 360102007424 nucleotide binding site [chemical binding]; other site 360102007425 putative NEF/HSP70 interaction site [polypeptide binding]; other site 360102007426 SBD interface [polypeptide binding]; other site 360102007427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102007428 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102007429 DNA-binding interface [nucleotide binding]; DNA binding site 360102007430 Integrase core domain; Region: rve; pfam00665 360102007431 transposase/IS protein; Provisional; Region: PRK09183 360102007432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102007433 Walker A motif; other site 360102007434 ATP binding site [chemical binding]; other site 360102007435 Walker B motif; other site 360102007436 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 360102007437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007438 dimer interface [polypeptide binding]; other site 360102007439 conserved gate region; other site 360102007440 putative PBP binding loops; other site 360102007441 ABC-ATPase subunit interface; other site 360102007442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007443 dimer interface [polypeptide binding]; other site 360102007444 conserved gate region; other site 360102007445 putative PBP binding loops; other site 360102007446 ABC-ATPase subunit interface; other site 360102007447 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 360102007448 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 360102007449 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 360102007450 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360102007451 inhibitor-cofactor binding pocket; inhibition site 360102007452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102007453 catalytic residue [active] 360102007454 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 360102007455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360102007456 DNA-binding site [nucleotide binding]; DNA binding site 360102007457 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360102007458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102007459 homodimer interface [polypeptide binding]; other site 360102007460 catalytic residue [active] 360102007461 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 360102007462 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 360102007463 Walker A/P-loop; other site 360102007464 ATP binding site [chemical binding]; other site 360102007465 Q-loop/lid; other site 360102007466 ABC transporter signature motif; other site 360102007467 Walker B; other site 360102007468 D-loop; other site 360102007469 H-loop/switch region; other site 360102007470 TOBE domain; Region: TOBE_2; pfam08402 360102007471 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 360102007472 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102007473 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102007474 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 360102007475 Protein export membrane protein; Region: SecD_SecF; cl14618 360102007476 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 360102007477 Protein export membrane protein; Region: SecD_SecF; cl14618 360102007478 putative transporter; Provisional; Region: PRK10504 360102007479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102007480 putative substrate translocation pore; other site 360102007481 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 360102007482 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102007483 dimerization interface [polypeptide binding]; other site 360102007484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102007485 dimer interface [polypeptide binding]; other site 360102007486 phosphorylation site [posttranslational modification] 360102007487 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 360102007488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102007489 ATP binding site [chemical binding]; other site 360102007490 G-X-G motif; other site 360102007491 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 360102007492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102007493 active site 360102007494 phosphorylation site [posttranslational modification] 360102007495 intermolecular recognition site; other site 360102007496 dimerization interface [polypeptide binding]; other site 360102007497 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102007498 DNA binding site [nucleotide binding] 360102007499 Uncharacterized conserved protein [Function unknown]; Region: COG3422 360102007500 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 360102007501 putative protease; Provisional; Region: PRK15452 360102007502 Peptidase family U32; Region: Peptidase_U32; pfam01136 360102007503 lipid kinase; Reviewed; Region: PRK13054 360102007504 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 360102007505 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 360102007506 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 360102007507 substrate binding site [chemical binding]; other site 360102007508 dimer interface [polypeptide binding]; other site 360102007509 ATP binding site [chemical binding]; other site 360102007510 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 360102007511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102007512 MULE transposase domain; Region: MULE; pfam10551 360102007513 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 360102007514 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 360102007515 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 360102007516 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 360102007517 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 360102007518 Transposase IS200 like; Region: Y1_Tnp; cl00848 360102007519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 360102007520 GMP synthase; Reviewed; Region: guaA; PRK00074 360102007521 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 360102007522 AMP/PPi binding site [chemical binding]; other site 360102007523 candidate oxyanion hole; other site 360102007524 catalytic triad [active] 360102007525 potential glutamine specificity residues [chemical binding]; other site 360102007526 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 360102007527 ATP Binding subdomain [chemical binding]; other site 360102007528 Ligand Binding sites [chemical binding]; other site 360102007529 Dimerization subdomain; other site 360102007530 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 360102007531 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 360102007532 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 360102007533 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 360102007534 active site 360102007535 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 360102007536 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 360102007537 generic binding surface II; other site 360102007538 generic binding surface I; other site 360102007539 Predicted permeases [General function prediction only]; Region: COG0679 360102007540 GTP-binding protein Der; Reviewed; Region: PRK00093 360102007541 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 360102007542 G1 box; other site 360102007543 GTP/Mg2+ binding site [chemical binding]; other site 360102007544 Switch I region; other site 360102007545 G2 box; other site 360102007546 Switch II region; other site 360102007547 G3 box; other site 360102007548 G4 box; other site 360102007549 G5 box; other site 360102007550 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 360102007551 G1 box; other site 360102007552 GTP/Mg2+ binding site [chemical binding]; other site 360102007553 Switch I region; other site 360102007554 G2 box; other site 360102007555 G3 box; other site 360102007556 Switch II region; other site 360102007557 G4 box; other site 360102007558 G5 box; other site 360102007559 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 360102007560 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 360102007561 Trp docking motif [polypeptide binding]; other site 360102007562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 360102007563 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 360102007564 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 360102007565 dimer interface [polypeptide binding]; other site 360102007566 motif 1; other site 360102007567 active site 360102007568 motif 2; other site 360102007569 motif 3; other site 360102007570 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 360102007571 anticodon binding site; other site 360102007572 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 360102007573 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 360102007574 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 360102007575 cytoskeletal protein RodZ; Provisional; Region: PRK10856 360102007576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360102007577 non-specific DNA binding site [nucleotide binding]; other site 360102007578 salt bridge; other site 360102007579 sequence-specific DNA binding site [nucleotide binding]; other site 360102007580 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 360102007581 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 360102007582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360102007583 binding surface 360102007584 TPR motif; other site 360102007585 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 360102007586 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102007587 FeS/SAM binding site; other site 360102007588 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 360102007589 active site 360102007590 multimer interface [polypeptide binding]; other site 360102007591 Protein of unkown function (DUF1881); Region: DUF1881; pfam08964 360102007592 Beta/Gamma crystallin; Region: Crystall; cl02528 360102007593 Beta/Gamma crystallin; Region: Crystall; cl02528 360102007594 Exotoxin A binding; Region: Exotox-A_bind; pfam09101 360102007595 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 360102007596 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 360102007597 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 360102007598 Autotransporter beta-domain; Region: Autotransporter; pfam03797 360102007599 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 360102007600 Autotransporter beta-domain; Region: Autotransporter; pfam03797 360102007601 Autotransporter beta-domain; Region: Autotransporter; smart00869 360102007602 SseB protein; Region: SseB; pfam07179 360102007603 aminopeptidase B; Provisional; Region: PRK05015 360102007604 Peptidase; Region: DUF3663; pfam12404 360102007605 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 360102007606 interface (dimer of trimers) [polypeptide binding]; other site 360102007607 Substrate-binding/catalytic site; other site 360102007608 Zn-binding sites [ion binding]; other site 360102007609 hypothetical protein; Provisional; Region: PRK10721 360102007610 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 360102007611 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 360102007612 catalytic loop [active] 360102007613 iron binding site [ion binding]; other site 360102007614 chaperone protein HscA; Provisional; Region: hscA; PRK05183 360102007615 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 360102007616 nucleotide binding site [chemical binding]; other site 360102007617 putative NEF/HSP70 interaction site [polypeptide binding]; other site 360102007618 SBD interface [polypeptide binding]; other site 360102007619 co-chaperone HscB; Provisional; Region: hscB; PRK05014 360102007620 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 360102007621 HSP70 interaction site [polypeptide binding]; other site 360102007622 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 360102007623 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 360102007624 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 360102007625 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 360102007626 trimerization site [polypeptide binding]; other site 360102007627 active site 360102007628 cysteine desulfurase; Provisional; Region: PRK14012 360102007629 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 360102007630 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102007631 catalytic residue [active] 360102007632 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 360102007633 Rrf2 family protein; Region: rrf2_super; TIGR00738 360102007634 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 360102007635 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 360102007636 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 360102007637 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 360102007638 active site 360102007639 dimerization interface [polypeptide binding]; other site 360102007640 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 360102007641 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 360102007642 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 360102007643 PRD domain; Region: PRD; pfam00874 360102007644 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 360102007645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102007646 putative substrate translocation pore; other site 360102007647 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 360102007648 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 360102007649 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 360102007650 dimer interface [polypeptide binding]; other site 360102007651 active site 360102007652 glycine-pyridoxal phosphate binding site [chemical binding]; other site 360102007653 folate binding site [chemical binding]; other site 360102007654 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 360102007655 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 360102007656 heme-binding site [chemical binding]; other site 360102007657 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 360102007658 FAD binding pocket [chemical binding]; other site 360102007659 FAD binding motif [chemical binding]; other site 360102007660 phosphate binding motif [ion binding]; other site 360102007661 beta-alpha-beta structure motif; other site 360102007662 NAD binding pocket [chemical binding]; other site 360102007663 Heme binding pocket [chemical binding]; other site 360102007664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360102007665 DNA-binding site [nucleotide binding]; DNA binding site 360102007666 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 360102007667 Nitrogen regulatory protein P-II; Region: P-II; smart00938 360102007668 NAD synthetase; Provisional; Region: PRK13981 360102007669 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 360102007670 multimer interface [polypeptide binding]; other site 360102007671 active site 360102007672 catalytic triad [active] 360102007673 protein interface 1 [polypeptide binding]; other site 360102007674 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 360102007675 homodimer interface [polypeptide binding]; other site 360102007676 NAD binding pocket [chemical binding]; other site 360102007677 ATP binding pocket [chemical binding]; other site 360102007678 Mg binding site [ion binding]; other site 360102007679 active-site loop [active] 360102007680 response regulator GlrR; Provisional; Region: PRK15115 360102007681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102007682 active site 360102007683 phosphorylation site [posttranslational modification] 360102007684 intermolecular recognition site; other site 360102007685 dimerization interface [polypeptide binding]; other site 360102007686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102007687 Walker A motif; other site 360102007688 ATP binding site [chemical binding]; other site 360102007689 Walker B motif; other site 360102007690 arginine finger; other site 360102007691 hypothetical protein; Provisional; Region: PRK10722 360102007692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 360102007693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102007694 dimer interface [polypeptide binding]; other site 360102007695 phosphorylation site [posttranslational modification] 360102007696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102007697 ATP binding site [chemical binding]; other site 360102007698 Mg2+ binding site [ion binding]; other site 360102007699 G-X-G motif; other site 360102007700 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102007701 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 360102007702 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 360102007703 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 360102007704 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 360102007705 dimerization interface [polypeptide binding]; other site 360102007706 ATP binding site [chemical binding]; other site 360102007707 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 360102007708 dimerization interface [polypeptide binding]; other site 360102007709 ATP binding site [chemical binding]; other site 360102007710 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 360102007711 putative active site [active] 360102007712 catalytic triad [active] 360102007713 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 360102007714 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102007715 substrate binding pocket [chemical binding]; other site 360102007716 membrane-bound complex binding site; other site 360102007717 hinge residues; other site 360102007718 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 360102007719 N-acetyl-D-glucosamine binding site [chemical binding]; other site 360102007720 catalytic residue [active] 360102007721 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 360102007722 nucleoside/Zn binding site; other site 360102007723 dimer interface [polypeptide binding]; other site 360102007724 catalytic motif [active] 360102007725 haloacid dehalogenase superfamily, subfamily IF hydrolase, YfhB; Region: YfhB_g-proteo; TIGR01545 360102007726 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 360102007727 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 360102007728 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 360102007729 putative active site [active] 360102007730 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 360102007731 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 360102007732 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 360102007733 putative active site [active] 360102007734 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 360102007735 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102007736 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 360102007737 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 360102007738 active site 360102007739 hydrophilic channel; other site 360102007740 dimerization interface [polypeptide binding]; other site 360102007741 catalytic residues [active] 360102007742 active site lid [active] 360102007743 transposase/IS protein; Provisional; Region: PRK09183 360102007744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102007745 Walker A motif; other site 360102007746 ATP binding site [chemical binding]; other site 360102007747 Walker B motif; other site 360102007748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102007749 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102007750 DNA-binding interface [nucleotide binding]; DNA binding site 360102007751 Integrase core domain; Region: rve; pfam00665 360102007752 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 360102007753 tetramer interface [polypeptide binding]; other site 360102007754 active site 360102007755 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 360102007756 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 360102007757 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 360102007758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007759 dimer interface [polypeptide binding]; other site 360102007760 conserved gate region; other site 360102007761 putative PBP binding loops; other site 360102007762 ABC-ATPase subunit interface; other site 360102007763 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 360102007764 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 360102007765 Walker A/P-loop; other site 360102007766 ATP binding site [chemical binding]; other site 360102007767 Q-loop/lid; other site 360102007768 ABC transporter signature motif; other site 360102007769 Walker B; other site 360102007770 D-loop; other site 360102007771 H-loop/switch region; other site 360102007772 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 360102007773 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 360102007774 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 360102007775 dimer interface [polypeptide binding]; other site 360102007776 putative radical transfer pathway; other site 360102007777 diiron center [ion binding]; other site 360102007778 tyrosyl radical; other site 360102007779 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 360102007780 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 360102007781 Class I ribonucleotide reductase; Region: RNR_I; cd01679 360102007782 active site 360102007783 dimer interface [polypeptide binding]; other site 360102007784 catalytic residues [active] 360102007785 effector binding site; other site 360102007786 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 360102007787 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 360102007788 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 360102007789 catalytic residues [active] 360102007790 Protein of unknown function (DUF2002); Region: DUF2002; cl11580 360102007791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102007792 MULE transposase domain; Region: MULE; pfam10551 360102007793 hypothetical protein; Provisional; Region: PRK10556 360102007794 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 360102007795 MbeD/MobD like; Region: MbeD_MobD; pfam04899 360102007796 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 360102007797 DNA-binding site [nucleotide binding]; DNA binding site 360102007798 RNA-binding motif; other site 360102007799 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 360102007800 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 360102007801 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 360102007802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007803 dimer interface [polypeptide binding]; other site 360102007804 conserved gate region; other site 360102007805 putative PBP binding loops; other site 360102007806 ABC-ATPase subunit interface; other site 360102007807 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 360102007808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102007809 dimer interface [polypeptide binding]; other site 360102007810 conserved gate region; other site 360102007811 putative PBP binding loops; other site 360102007812 ABC-ATPase subunit interface; other site 360102007813 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102007814 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 360102007815 Walker A/P-loop; other site 360102007816 ATP binding site [chemical binding]; other site 360102007817 Q-loop/lid; other site 360102007818 ABC transporter signature motif; other site 360102007819 Walker B; other site 360102007820 D-loop; other site 360102007821 H-loop/switch region; other site 360102007822 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 360102007823 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102007824 Walker A/P-loop; other site 360102007825 ATP binding site [chemical binding]; other site 360102007826 Q-loop/lid; other site 360102007827 ABC transporter signature motif; other site 360102007828 Walker B; other site 360102007829 D-loop; other site 360102007830 H-loop/switch region; other site 360102007831 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 360102007832 alpha-gamma subunit interface [polypeptide binding]; other site 360102007833 beta-gamma subunit interface [polypeptide binding]; other site 360102007834 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 360102007835 alpha-beta subunit interface [polypeptide binding]; other site 360102007836 urease subunit alpha; Reviewed; Region: ureC; PRK13309 360102007837 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 360102007838 subunit interactions [polypeptide binding]; other site 360102007839 active site 360102007840 flap region; other site 360102007841 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 360102007842 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 360102007843 dimer interface [polypeptide binding]; other site 360102007844 catalytic residues [active] 360102007845 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 360102007846 UreF; Region: UreF; pfam01730 360102007847 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378 360102007848 UreD urease accessory protein; Region: UreD; pfam01774 360102007849 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 360102007850 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 360102007851 acid-resistance protein; Provisional; Region: hdeB; PRK11566 360102007852 voltage-gated potassium channel; Provisional; Region: PRK10537 360102007853 Ion channel; Region: Ion_trans_2; pfam07885 360102007854 TrkA-N domain; Region: TrkA_N; pfam02254 360102007855 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636 360102007856 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 360102007857 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 360102007858 active site 360102007859 P-loop; other site 360102007860 phosphorylation site [posttranslational modification] 360102007861 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 360102007862 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 360102007863 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 360102007864 methionine cluster; other site 360102007865 active site 360102007866 phosphorylation site [posttranslational modification] 360102007867 metal binding site [ion binding]; metal-binding site 360102007868 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 360102007869 Cupin domain; Region: Cupin_2; cl17218 360102007870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102007871 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 360102007872 putative active site [active] 360102007873 YdjC motif; other site 360102007874 Mg binding site [ion binding]; other site 360102007875 putative homodimer interface [polypeptide binding]; other site 360102007876 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 360102007877 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 360102007878 replication initiation regulator SeqA; Provisional; Region: PRK11187 360102007879 phosphoglucomutase; Validated; Region: PRK07564 360102007880 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 360102007881 active site 360102007882 substrate binding site [chemical binding]; other site 360102007883 metal binding site [ion binding]; metal-binding site 360102007884 Predicted membrane protein [Function unknown]; Region: COG2510 360102007885 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 360102007886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102007887 active site 360102007888 phosphorylation site [posttranslational modification] 360102007889 intermolecular recognition site; other site 360102007890 dimerization interface [polypeptide binding]; other site 360102007891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102007892 DNA binding site [nucleotide binding] 360102007893 sensor protein KdpD; Provisional; Region: PRK10490 360102007894 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 360102007895 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 360102007896 Ligand Binding Site [chemical binding]; other site 360102007897 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 360102007898 GAF domain; Region: GAF_3; pfam13492 360102007899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102007900 dimer interface [polypeptide binding]; other site 360102007901 phosphorylation site [posttranslational modification] 360102007902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102007903 ATP binding site [chemical binding]; other site 360102007904 Mg2+ binding site [ion binding]; other site 360102007905 G-X-G motif; other site 360102007906 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 360102007907 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 360102007908 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360102007909 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 360102007910 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 360102007911 hypothetical protein; Provisional; Region: PRK10167 360102007912 Uncharacterized conserved protein [Function unknown]; Region: COG3272 360102007913 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 360102007914 DNA photolyase; Region: DNA_photolyase; pfam00875 360102007915 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 360102007916 Uncharacterized conserved protein [Function unknown]; Region: COG0327 360102007917 metal-binding protein; Provisional; Region: PRK10799 360102007918 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 360102007919 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 360102007920 similar to putative carboxylase 360102007921 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 360102007922 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 360102007923 putative active site [active] 360102007924 Predicted membrane protein [Function unknown]; Region: COG3819 360102007925 Predicted membrane protein [Function unknown]; Region: COG3817 360102007926 Predicted membrane protein [Function unknown]; Region: COG3817 360102007927 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 360102007928 putative substrate binding pocket [chemical binding]; other site 360102007929 AC domain interface; other site 360102007930 catalytic triad [active] 360102007931 AB domain interface; other site 360102007932 interchain disulfide; other site 360102007933 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 360102007934 ligand binding site [chemical binding]; other site 360102007935 active site 360102007936 UGI interface [polypeptide binding]; other site 360102007937 catalytic site [active] 360102007938 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 360102007939 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 360102007940 nucleophilic elbow; other site 360102007941 catalytic triad; other site 360102007942 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 360102007943 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 360102007944 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 360102007945 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 360102007946 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360102007947 ATP binding site [chemical binding]; other site 360102007948 Mg++ binding site [ion binding]; other site 360102007949 motif III; other site 360102007950 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102007951 nucleotide binding region [chemical binding]; other site 360102007952 ATP-binding site [chemical binding]; other site 360102007953 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 360102007954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102007955 S-adenosylmethionine binding site [chemical binding]; other site 360102007956 L-aspartate oxidase; Provisional; Region: PRK09077 360102007957 L-aspartate oxidase; Provisional; Region: PRK06175 360102007958 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 360102007959 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 360102007960 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360102007961 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360102007962 DNA binding residues [nucleotide binding] 360102007963 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 360102007964 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 360102007965 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 360102007966 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 360102007967 anti-sigma E factor; Provisional; Region: rseB; PRK09455 360102007968 SoxR reducing system protein RseC; Provisional; Region: PRK10862 360102007969 GTP-binding protein LepA; Provisional; Region: PRK05433 360102007970 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 360102007971 G1 box; other site 360102007972 putative GEF interaction site [polypeptide binding]; other site 360102007973 GTP/Mg2+ binding site [chemical binding]; other site 360102007974 Switch I region; other site 360102007975 G2 box; other site 360102007976 G3 box; other site 360102007977 Switch II region; other site 360102007978 G4 box; other site 360102007979 G5 box; other site 360102007980 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 360102007981 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 360102007982 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 360102007983 signal peptidase I; Provisional; Region: PRK10861 360102007984 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 360102007985 Catalytic site [active] 360102007986 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 360102007987 ribonuclease III; Reviewed; Region: rnc; PRK00102 360102007988 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 360102007989 dimerization interface [polypeptide binding]; other site 360102007990 active site 360102007991 metal binding site [ion binding]; metal-binding site 360102007992 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 360102007993 dsRNA binding site [nucleotide binding]; other site 360102007994 GTPase Era; Reviewed; Region: era; PRK00089 360102007995 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 360102007996 G1 box; other site 360102007997 GTP/Mg2+ binding site [chemical binding]; other site 360102007998 Switch I region; other site 360102007999 G2 box; other site 360102008000 Switch II region; other site 360102008001 G3 box; other site 360102008002 G4 box; other site 360102008003 G5 box; other site 360102008004 KH domain; Region: KH_2; pfam07650 360102008005 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 360102008006 Recombination protein O N terminal; Region: RecO_N; pfam11967 360102008007 Recombination protein O C terminal; Region: RecO_C; pfam02565 360102008008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102008009 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102008010 DNA-binding interface [nucleotide binding]; DNA binding site 360102008011 Integrase core domain; Region: rve; pfam00665 360102008012 transposase/IS protein; Provisional; Region: PRK09183 360102008013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102008014 Walker A motif; other site 360102008015 ATP binding site [chemical binding]; other site 360102008016 Walker B motif; other site 360102008017 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360102008018 Transposase; Region: HTH_Tnp_1; pfam01527 360102008019 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360102008020 active site 360102008021 Int/Topo IB signature motif; other site 360102008022 acyl-CoA esterase; Provisional; Region: PRK10673 360102008023 PGAP1-like protein; Region: PGAP1; pfam07819 360102008024 LexA regulated protein; Provisional; Region: PRK11675 360102008025 flavodoxin FldA; Validated; Region: PRK09267 360102008026 ferric uptake regulator; Provisional; Region: fur; PRK09462 360102008027 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 360102008028 metal binding site 2 [ion binding]; metal-binding site 360102008029 putative DNA binding helix; other site 360102008030 metal binding site 1 [ion binding]; metal-binding site 360102008031 dimer interface [polypeptide binding]; other site 360102008032 structural Zn2+ binding site [ion binding]; other site 360102008033 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 360102008034 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 360102008035 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 360102008036 active site 360102008037 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 360102008038 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 360102008039 outer membrane porin, OprD family; Region: OprD; pfam03573 360102008040 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 360102008041 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 360102008042 active site 360102008043 HIGH motif; other site 360102008044 nucleotide binding site [chemical binding]; other site 360102008045 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 360102008046 KMSKS motif; other site 360102008047 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 360102008048 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102008049 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 360102008050 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360102008051 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360102008052 active site turn [active] 360102008053 phosphorylation site [posttranslational modification] 360102008054 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 360102008055 HPr interaction site; other site 360102008056 glycerol kinase (GK) interaction site [polypeptide binding]; other site 360102008057 active site 360102008058 phosphorylation site [posttranslational modification] 360102008059 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 360102008060 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 360102008061 active site 360102008062 trimer interface [polypeptide binding]; other site 360102008063 allosteric site; other site 360102008064 active site lid [active] 360102008065 hexamer (dimer of trimers) interface [polypeptide binding]; other site 360102008066 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 360102008067 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 360102008068 active site 360102008069 dimer interface [polypeptide binding]; other site 360102008070 MarR family; Region: MarR; pfam01047 360102008071 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 360102008072 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360102008073 nucleotide binding site [chemical binding]; other site 360102008074 UMP phosphatase; Provisional; Region: PRK10444 360102008075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102008076 active site 360102008077 motif I; other site 360102008078 motif II; other site 360102008079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102008080 asparagine synthetase B; Provisional; Region: asnB; PRK09431 360102008081 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 360102008082 active site 360102008083 dimer interface [polypeptide binding]; other site 360102008084 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 360102008085 Ligand Binding Site [chemical binding]; other site 360102008086 Molecular Tunnel; other site 360102008087 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 360102008088 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 360102008089 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 360102008090 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 360102008091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102008092 FeS/SAM binding site; other site 360102008093 TRAM domain; Region: TRAM; pfam01938 360102008094 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 360102008095 PhoH-like protein; Region: PhoH; pfam02562 360102008096 metal-binding heat shock protein; Provisional; Region: PRK00016 360102008097 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 360102008098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 360102008099 Transporter associated domain; Region: CorC_HlyC; smart01091 360102008100 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 360102008101 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 360102008102 putative active site [active] 360102008103 catalytic triad [active] 360102008104 putative dimer interface [polypeptide binding]; other site 360102008105 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 360102008106 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102008107 substrate binding pocket [chemical binding]; other site 360102008108 membrane-bound complex binding site; other site 360102008109 hinge residues; other site 360102008110 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360102008111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102008112 dimer interface [polypeptide binding]; other site 360102008113 conserved gate region; other site 360102008114 putative PBP binding loops; other site 360102008115 ABC-ATPase subunit interface; other site 360102008116 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360102008117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102008118 dimer interface [polypeptide binding]; other site 360102008119 conserved gate region; other site 360102008120 putative PBP binding loops; other site 360102008121 ABC-ATPase subunit interface; other site 360102008122 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 360102008123 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 360102008124 Walker A/P-loop; other site 360102008125 ATP binding site [chemical binding]; other site 360102008126 Q-loop/lid; other site 360102008127 ABC transporter signature motif; other site 360102008128 Walker B; other site 360102008129 D-loop; other site 360102008130 H-loop/switch region; other site 360102008131 hypothetical protein; Provisional; Region: PRK11032 360102008132 Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488 360102008133 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 360102008134 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 360102008135 HIGH motif; other site 360102008136 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 360102008137 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 360102008138 active site 360102008139 KMSKS motif; other site 360102008140 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 360102008141 tRNA binding surface [nucleotide binding]; other site 360102008142 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 360102008143 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 360102008144 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 360102008145 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 360102008146 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 360102008147 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 360102008148 active site 360102008149 (T/H)XGH motif; other site 360102008150 ribosome-associated protein; Provisional; Region: PRK11538 360102008151 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 360102008152 penicillin-binding protein 2; Provisional; Region: PRK10795 360102008153 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 360102008154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 360102008155 cell wall shape-determining protein; Provisional; Region: PRK10794 360102008156 rare lipoprotein A; Provisional; Region: PRK10672 360102008157 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 360102008158 Sporulation related domain; Region: SPOR; pfam05036 360102008159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102008160 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102008161 DNA-binding interface [nucleotide binding]; DNA binding site 360102008162 Integrase core domain; Region: rve; pfam00665 360102008163 transposase/IS protein; Provisional; Region: PRK09183 360102008164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102008165 Walker A motif; other site 360102008166 ATP binding site [chemical binding]; other site 360102008167 Walker B motif; other site 360102008168 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 360102008169 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 360102008170 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 360102008171 hypothetical protein; Provisional; Region: PRK04998 360102008172 lipoate-protein ligase B; Provisional; Region: PRK14342 360102008173 lipoyl synthase; Provisional; Region: PRK05481 360102008174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102008175 FeS/SAM binding site; other site 360102008176 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 360102008177 chromosome condensation membrane protein; Provisional; Region: PRK14196 360102008178 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 360102008179 DNA-binding site [nucleotide binding]; DNA binding site 360102008180 RNA-binding motif; other site 360102008181 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 360102008182 DNA-binding site [nucleotide binding]; DNA binding site 360102008183 RNA-binding motif; other site 360102008184 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 360102008185 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102008186 DNA binding residues [nucleotide binding] 360102008187 dimerization interface [polypeptide binding]; other site 360102008188 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 360102008189 Glycogen synthesis protein; Region: GlgS; cl11663 360102008190 Uncharacterized conserved protein [Function unknown]; Region: COG1359 360102008191 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360102008192 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 360102008193 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 360102008194 Walker A/P-loop; other site 360102008195 ATP binding site [chemical binding]; other site 360102008196 Q-loop/lid; other site 360102008197 ABC transporter signature motif; other site 360102008198 Walker B; other site 360102008199 D-loop; other site 360102008200 H-loop/switch region; other site 360102008201 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 360102008202 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 360102008203 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 360102008204 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360102008205 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 360102008206 substrate binding site [chemical binding]; other site 360102008207 ATP binding site [chemical binding]; other site 360102008208 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360102008209 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360102008210 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102008211 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102008212 TM-ABC transporter signature motif; other site 360102008213 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360102008214 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102008215 Walker A/P-loop; other site 360102008216 ATP binding site [chemical binding]; other site 360102008217 Q-loop/lid; other site 360102008218 ABC transporter signature motif; other site 360102008219 Walker B; other site 360102008220 D-loop; other site 360102008221 H-loop/switch region; other site 360102008222 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102008223 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 360102008224 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 360102008225 ligand binding site [chemical binding]; other site 360102008226 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 360102008227 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360102008228 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360102008229 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360102008230 Domain of unknown function (DUF1886); Region: DUF1886; cl01666 360102008231 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 360102008232 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 360102008233 PYR/PP interface [polypeptide binding]; other site 360102008234 dimer interface [polypeptide binding]; other site 360102008235 TPP binding site [chemical binding]; other site 360102008236 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 360102008237 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 360102008238 TPP-binding site; other site 360102008239 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 360102008240 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 360102008241 tetrameric interface [polypeptide binding]; other site 360102008242 NAD binding site [chemical binding]; other site 360102008243 catalytic residues [active] 360102008244 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 360102008245 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 360102008246 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 360102008247 putative active site [active] 360102008248 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 360102008249 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 360102008250 MG2 domain; Region: A2M_N; pfam01835 360102008251 Alpha-2-macroglobulin family; Region: A2M; pfam00207 360102008252 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 360102008253 surface patch; other site 360102008254 thioester region; other site 360102008255 specificity defining residues; other site 360102008256 Transglycosylase; Region: Transgly; pfam00912 360102008257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102008258 MULE transposase domain; Region: MULE; pfam10551 360102008259 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 360102008260 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 360102008261 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 360102008262 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 360102008263 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 360102008264 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 360102008265 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 360102008266 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 360102008267 Autotransporter beta-domain; Region: Autotransporter; pfam03797 360102008268 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 360102008269 Uncharacterized conserved protein [Function unknown]; Region: COG2850 360102008270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102008271 MULE transposase domain; Region: MULE; pfam10551 360102008272 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 360102008273 Predicted membrane protein [Function unknown]; Region: COG4984 360102008274 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 360102008275 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 360102008276 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 360102008277 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 360102008278 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360102008279 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360102008280 active site 360102008281 catalytic tetrad [active] 360102008282 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360102008283 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360102008284 active site 360102008285 catalytic tetrad [active] 360102008286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102008287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102008288 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 360102008289 putative effector binding pocket; other site 360102008290 putative dimerization interface [polypeptide binding]; other site 360102008291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102008292 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102008293 DNA-binding interface [nucleotide binding]; DNA binding site 360102008294 Integrase core domain; Region: rve; pfam00665 360102008295 transposase/IS protein; Provisional; Region: PRK09183 360102008296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102008297 Walker A motif; other site 360102008298 ATP binding site [chemical binding]; other site 360102008299 Walker B motif; other site 360102008300 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 360102008301 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 360102008302 active site 360102008303 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 360102008304 active site 360102008305 catalytic residues [active] 360102008306 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 360102008307 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 360102008308 Putative methyltransferase; Region: Methyltransf_20; pfam12147 360102008309 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 360102008310 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 360102008311 putative acyl-acceptor binding pocket; other site 360102008312 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 360102008313 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 360102008314 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 360102008315 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 360102008316 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 360102008317 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 360102008318 homodimer interface [polypeptide binding]; other site 360102008319 NADP binding site [chemical binding]; other site 360102008320 substrate binding site [chemical binding]; other site 360102008321 ribosome-associated protein; Provisional; Region: PRK11507 360102008322 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102008323 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 360102008324 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 360102008325 active site 360102008326 HIGH motif; other site 360102008327 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 360102008328 KMSKS motif; other site 360102008329 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 360102008330 tRNA binding surface [nucleotide binding]; other site 360102008331 anticodon binding site; other site 360102008332 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 360102008333 substrate binding site [chemical binding]; other site 360102008334 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 360102008335 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 360102008336 putative active site [active] 360102008337 putative metal binding site [ion binding]; other site 360102008338 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 360102008339 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 360102008340 ATP-grasp domain; Region: ATP-grasp; pfam02222 360102008341 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 360102008342 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 360102008343 FtsX-like permease family; Region: FtsX; pfam02687 360102008344 FtsX-like permease family; Region: FtsX; pfam02687 360102008345 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 360102008346 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 360102008347 Walker A/P-loop; other site 360102008348 ATP binding site [chemical binding]; other site 360102008349 Q-loop/lid; other site 360102008350 ABC transporter signature motif; other site 360102008351 Walker B; other site 360102008352 D-loop; other site 360102008353 H-loop/switch region; other site 360102008354 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 360102008355 active site 360102008356 catalytic triad [active] 360102008357 oxyanion hole [active] 360102008358 switch loop; other site 360102008359 oxidoreductase; Provisional; Region: PRK08017 360102008360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360102008361 NAD(P) binding site [chemical binding]; other site 360102008362 active site 360102008363 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 360102008364 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 360102008365 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 360102008366 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 360102008367 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 360102008368 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 360102008369 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 360102008370 DNA binding residues [nucleotide binding] 360102008371 dimer interface [polypeptide binding]; other site 360102008372 copper binding site [ion binding]; other site 360102008373 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 360102008374 metal-binding site [ion binding] 360102008375 copper exporting ATPase; Provisional; Region: copA; PRK10671 360102008376 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 360102008377 metal-binding site [ion binding] 360102008378 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 360102008379 metal-binding site [ion binding] 360102008380 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360102008381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102008382 motif II; other site 360102008383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 360102008384 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 360102008385 putative deacylase active site [active] 360102008386 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 360102008387 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 360102008388 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 360102008389 active site 360102008390 metal binding site [ion binding]; metal-binding site 360102008391 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 360102008392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102008393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360102008394 putative substrate translocation pore; other site 360102008395 putative cation:proton antiport protein; Provisional; Region: PRK10669 360102008396 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 360102008397 TrkA-N domain; Region: TrkA_N; pfam02254 360102008398 inosine/guanosine kinase; Provisional; Region: PRK15074 360102008399 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360102008400 substrate binding site [chemical binding]; other site 360102008401 ATP binding site [chemical binding]; other site 360102008402 LPS O-antigen length regulator; Provisional; Region: PRK10381 360102008403 Chain length determinant protein; Region: Wzz; pfam02706 360102008404 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 360102008405 phosphomannomutase CpsG; Provisional; Region: PRK15414 360102008406 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 360102008407 active site 360102008408 substrate binding site [chemical binding]; other site 360102008409 metal binding site [ion binding]; metal-binding site 360102008410 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 360102008411 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 360102008412 metal-binding site 360102008413 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 360102008414 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 360102008415 Substrate binding site; other site 360102008416 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 360102008417 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 360102008418 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 360102008419 NADP binding site [chemical binding]; other site 360102008420 active site 360102008421 putative substrate binding site [chemical binding]; other site 360102008422 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 360102008423 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 360102008424 substrate binding site [chemical binding]; other site 360102008425 active site 360102008426 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 360102008427 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 360102008428 NADP-binding site; other site 360102008429 homotetramer interface [polypeptide binding]; other site 360102008430 homodimer interface [polypeptide binding]; other site 360102008431 active site 360102008432 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 360102008433 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 360102008434 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 360102008435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360102008436 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 360102008437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360102008438 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 360102008439 NAD(P) binding site [chemical binding]; other site 360102008440 active site 360102008441 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 360102008442 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 360102008443 inhibitor-cofactor binding pocket; inhibition site 360102008444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102008445 catalytic residue [active] 360102008446 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 360102008447 NAD binding site [chemical binding]; other site 360102008448 homotetramer interface [polypeptide binding]; other site 360102008449 homodimer interface [polypeptide binding]; other site 360102008450 substrate binding site [chemical binding]; other site 360102008451 active site 360102008452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 360102008453 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 360102008454 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 360102008455 substrate binding site; other site 360102008456 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 360102008457 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 360102008458 catalytic loop [active] 360102008459 iron binding site [ion binding]; other site 360102008460 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 360102008461 FAD binding pocket [chemical binding]; other site 360102008462 FAD binding motif [chemical binding]; other site 360102008463 phosphate binding motif [ion binding]; other site 360102008464 beta-alpha-beta structure motif; other site 360102008465 NAD binding pocket [chemical binding]; other site 360102008466 ferrochelatase; Reviewed; Region: hemH; PRK00035 360102008467 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 360102008468 C-terminal domain interface [polypeptide binding]; other site 360102008469 active site 360102008470 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 360102008471 active site 360102008472 N-terminal domain interface [polypeptide binding]; other site 360102008473 adenylate kinase; Reviewed; Region: adk; PRK00279 360102008474 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 360102008475 AMP-binding site [chemical binding]; other site 360102008476 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 360102008477 heat shock protein 90; Provisional; Region: PRK05218 360102008478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102008479 ATP binding site [chemical binding]; other site 360102008480 Mg2+ binding site [ion binding]; other site 360102008481 G-X-G motif; other site 360102008482 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 360102008483 RecR protein; Region: RecR; pfam02132 360102008484 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 360102008485 putative active site [active] 360102008486 putative metal-binding site [ion binding]; other site 360102008487 tetramer interface [polypeptide binding]; other site 360102008488 hypothetical protein; Validated; Region: PRK00153 360102008489 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 360102008490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102008491 Walker A motif; other site 360102008492 ATP binding site [chemical binding]; other site 360102008493 Walker B motif; other site 360102008494 arginine finger; other site 360102008495 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 360102008496 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 360102008497 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 360102008498 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360102008499 active site 360102008500 hypothetical protein; Provisional; Region: PRK10527 360102008501 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 360102008502 hypothetical protein; Provisional; Region: PRK11038 360102008503 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 360102008504 Mechanosensitive ion channel; Region: MS_channel; pfam00924 360102008505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102008506 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102008507 DNA-binding interface [nucleotide binding]; DNA binding site 360102008508 Integrase core domain; Region: rve; pfam00665 360102008509 transposase/IS protein; Provisional; Region: PRK09183 360102008510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102008511 Walker A motif; other site 360102008512 ATP binding site [chemical binding]; other site 360102008513 Walker B motif; other site 360102008514 Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795 360102008515 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 360102008516 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 360102008517 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 360102008518 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 360102008519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360102008520 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 360102008521 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 360102008522 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102008523 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102008524 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 360102008525 Protein export membrane protein; Region: SecD_SecF; cl14618 360102008526 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 360102008527 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 360102008528 Hha toxicity attenuator; Provisional; Region: PRK10667 360102008529 gene expression modulator; Provisional; Region: PRK10945 360102008530 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 360102008531 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 360102008532 DNA binding site [nucleotide binding] 360102008533 active site 360102008534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 360102008535 acyl-CoA thioesterase II; Provisional; Region: PRK10526 360102008536 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 360102008537 active site 360102008538 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 360102008539 catalytic triad [active] 360102008540 dimer interface [polypeptide binding]; other site 360102008541 ammonium transporter; Provisional; Region: PRK10666 360102008542 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 360102008543 Nitrogen regulatory protein P-II; Region: P-II; smart00938 360102008544 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 360102008545 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360102008546 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 360102008547 Walker A/P-loop; other site 360102008548 ATP binding site [chemical binding]; other site 360102008549 Q-loop/lid; other site 360102008550 ABC transporter signature motif; other site 360102008551 Walker B; other site 360102008552 D-loop; other site 360102008553 H-loop/switch region; other site 360102008554 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 360102008555 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360102008556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102008557 Walker A/P-loop; other site 360102008558 ATP binding site [chemical binding]; other site 360102008559 Q-loop/lid; other site 360102008560 ABC transporter signature motif; other site 360102008561 Walker B; other site 360102008562 D-loop; other site 360102008563 H-loop/switch region; other site 360102008564 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 360102008565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360102008566 putative DNA binding site [nucleotide binding]; other site 360102008567 putative Zn2+ binding site [ion binding]; other site 360102008568 AsnC family; Region: AsnC_trans_reg; pfam01037 360102008569 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 360102008570 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 360102008571 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102008572 catalytic residue [active] 360102008573 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 360102008574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102008575 active site 360102008576 motif I; other site 360102008577 motif II; other site 360102008578 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 360102008579 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 360102008580 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 360102008581 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 360102008582 Ligand Binding Site [chemical binding]; other site 360102008583 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 360102008584 active site 360102008585 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 360102008586 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 360102008587 periplasmic folding chaperone; Provisional; Region: PRK10788 360102008588 SurA N-terminal domain; Region: SurA_N_3; cl07813 360102008589 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 360102008590 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 360102008591 IHF dimer interface [polypeptide binding]; other site 360102008592 IHF - DNA interface [nucleotide binding]; other site 360102008593 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 360102008594 Found in ATP-dependent protease La (LON); Region: LON; smart00464 360102008595 Found in ATP-dependent protease La (LON); Region: LON; smart00464 360102008596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102008597 Walker A motif; other site 360102008598 ATP binding site [chemical binding]; other site 360102008599 Walker B motif; other site 360102008600 arginine finger; other site 360102008601 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 360102008602 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 360102008603 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 360102008604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102008605 Walker A motif; other site 360102008606 ATP binding site [chemical binding]; other site 360102008607 Walker B motif; other site 360102008608 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 360102008609 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 360102008610 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 360102008611 oligomer interface [polypeptide binding]; other site 360102008612 active site residues [active] 360102008613 trigger factor; Provisional; Region: tig; PRK01490 360102008614 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 360102008615 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 360102008616 transcriptional regulator BolA; Provisional; Region: PRK11628 360102008617 hypothetical protein; Provisional; Region: PRK11627 360102008618 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 360102008619 muropeptide transporter; Reviewed; Region: ampG; PRK11902 360102008620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102008621 putative substrate translocation pore; other site 360102008622 hypothetical protein; Provisional; Region: PRK11528 360102008623 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 360102008624 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 360102008625 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 360102008626 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 360102008627 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 360102008628 D-pathway; other site 360102008629 Putative ubiquinol binding site [chemical binding]; other site 360102008630 Low-spin heme (heme b) binding site [chemical binding]; other site 360102008631 Putative water exit pathway; other site 360102008632 Binuclear center (heme o3/CuB) [ion binding]; other site 360102008633 K-pathway; other site 360102008634 Putative proton exit pathway; other site 360102008635 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 360102008636 Subunit I/III interface [polypeptide binding]; other site 360102008637 Subunit III/IV interface [polypeptide binding]; other site 360102008638 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 360102008639 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 360102008640 UbiA prenyltransferase family; Region: UbiA; pfam01040 360102008641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102008642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 360102008643 putative substrate translocation pore; other site 360102008644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 360102008645 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 360102008646 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 360102008647 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 360102008648 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 360102008649 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 360102008650 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 360102008651 conserved cys residue [active] 360102008652 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 360102008653 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 360102008654 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 360102008655 Ligand Binding Site [chemical binding]; other site 360102008656 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360102008657 active site residue [active] 360102008658 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 360102008659 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 360102008660 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 360102008661 substrate binding pocket [chemical binding]; other site 360102008662 chain length determination region; other site 360102008663 substrate-Mg2+ binding site; other site 360102008664 catalytic residues [active] 360102008665 aspartate-rich region 1; other site 360102008666 active site lid residues [active] 360102008667 aspartate-rich region 2; other site 360102008668 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 360102008669 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 360102008670 TPP-binding site; other site 360102008671 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 360102008672 PYR/PP interface [polypeptide binding]; other site 360102008673 dimer interface [polypeptide binding]; other site 360102008674 TPP binding site [chemical binding]; other site 360102008675 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 360102008676 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102008677 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 360102008678 tetramer interfaces [polypeptide binding]; other site 360102008679 binuclear metal-binding site [ion binding]; other site 360102008680 thiamine monophosphate kinase; Provisional; Region: PRK05731 360102008681 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 360102008682 ATP binding site [chemical binding]; other site 360102008683 dimerization interface [polypeptide binding]; other site 360102008684 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 360102008685 putative RNA binding site [nucleotide binding]; other site 360102008686 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 360102008687 homopentamer interface [polypeptide binding]; other site 360102008688 active site 360102008689 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 360102008690 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 360102008691 catalytic motif [active] 360102008692 Zn binding site [ion binding]; other site 360102008693 RibD C-terminal domain; Region: RibD_C; cl17279 360102008694 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 360102008695 ATP cone domain; Region: ATP-cone; pfam03477 360102008696 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102008697 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102008698 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 360102008699 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 360102008700 Protein export membrane protein; Region: SecD_SecF; pfam02355 360102008701 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 360102008702 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 360102008703 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 360102008704 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 360102008705 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 360102008706 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 360102008707 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 360102008708 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 360102008709 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 360102008710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3124 360102008711 peroxidase; Provisional; Region: PRK15000 360102008712 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 360102008713 dimer interface [polypeptide binding]; other site 360102008714 decamer (pentamer of dimers) interface [polypeptide binding]; other site 360102008715 catalytic triad [active] 360102008716 peroxidatic and resolving cysteines [active] 360102008717 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 360102008718 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 360102008719 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 360102008720 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 360102008721 C factor cell-cell signaling protein; Provisional; Region: PRK09009 360102008722 NADP binding site [chemical binding]; other site 360102008723 homodimer interface [polypeptide binding]; other site 360102008724 active site 360102008725 maltodextrin glucosidase; Provisional; Region: PRK10785 360102008726 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 360102008727 homodimer interface [polypeptide binding]; other site 360102008728 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 360102008729 active site 360102008730 homodimer interface [polypeptide binding]; other site 360102008731 catalytic site [active] 360102008732 putative proline-specific permease; Provisional; Region: proY; PRK10580 360102008733 Spore germination protein; Region: Spore_permease; cl17796 360102008734 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 360102008735 PBP superfamily domain; Region: PBP_like_2; cl17296 360102008736 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 360102008737 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 360102008738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360102008739 putative active site [active] 360102008740 heme pocket [chemical binding]; other site 360102008741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102008742 dimer interface [polypeptide binding]; other site 360102008743 phosphorylation site [posttranslational modification] 360102008744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102008745 ATP binding site [chemical binding]; other site 360102008746 Mg2+ binding site [ion binding]; other site 360102008747 G-X-G motif; other site 360102008748 transcriptional regulator PhoB; Provisional; Region: PRK10161 360102008749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102008750 active site 360102008751 phosphorylation site [posttranslational modification] 360102008752 intermolecular recognition site; other site 360102008753 dimerization interface [polypeptide binding]; other site 360102008754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102008755 DNA binding site [nucleotide binding] 360102008756 exonuclease subunit SbcD; Provisional; Region: PRK10966 360102008757 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 360102008758 active site 360102008759 metal binding site [ion binding]; metal-binding site 360102008760 DNA binding site [nucleotide binding] 360102008761 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 360102008762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102008763 AAA domain; Region: AAA_23; pfam13476 360102008764 Walker A/P-loop; other site 360102008765 ATP binding site [chemical binding]; other site 360102008766 Q-loop/lid; other site 360102008767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102008768 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102008769 DNA-binding interface [nucleotide binding]; DNA binding site 360102008770 Integrase core domain; Region: rve; pfam00665 360102008771 transposase/IS protein; Provisional; Region: PRK09183 360102008772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102008773 Walker A motif; other site 360102008774 ATP binding site [chemical binding]; other site 360102008775 Walker B motif; other site 360102008776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102008777 ABC transporter signature motif; other site 360102008778 Walker B; other site 360102008779 D-loop; other site 360102008780 H-loop/switch region; other site 360102008781 fructokinase; Reviewed; Region: PRK09557 360102008782 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360102008783 nucleotide binding site [chemical binding]; other site 360102008784 recombination associated protein; Reviewed; Region: rdgC; PRK00321 360102008785 hypothetical protein; Provisional; Region: PRK10579 360102008786 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 360102008787 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 360102008788 ADP binding site [chemical binding]; other site 360102008789 magnesium binding site [ion binding]; other site 360102008790 putative shikimate binding site; other site 360102008791 Phospholipid N-methyltransferase [Lipid metabolism]; Region: COG3963 360102008792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102008793 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 360102008794 Flagellar regulator YcgR; Region: YcgR; pfam07317 360102008795 PilZ domain; Region: PilZ; pfam07238 360102008796 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 360102008797 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 360102008798 putative catalytic cysteine [active] 360102008799 gamma-glutamyl kinase; Provisional; Region: PRK05429 360102008800 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 360102008801 nucleotide binding site [chemical binding]; other site 360102008802 homotetrameric interface [polypeptide binding]; other site 360102008803 putative phosphate binding site [ion binding]; other site 360102008804 putative allosteric binding site; other site 360102008805 PUA domain; Region: PUA; pfam01472 360102008806 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 360102008807 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 360102008808 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 360102008809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360102008810 active site 360102008811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 360102008812 Chitin binding domain; Region: Chitin_bind_3; pfam03067 360102008813 PKD domain; Region: PKD; pfam00801 360102008814 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102008815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102008816 LysR substrate binding domain; Region: LysR_substrate; pfam03466 360102008817 dimerization interface [polypeptide binding]; other site 360102008818 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 360102008819 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 360102008820 metal binding site [ion binding]; metal-binding site 360102008821 dimer interface [polypeptide binding]; other site 360102008822 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 360102008823 active site 360102008824 DNA polymerase IV; Validated; Region: PRK02406 360102008825 DNA binding site [nucleotide binding] 360102008826 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 360102008827 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 360102008828 putative active site [active] 360102008829 catalytic site [active] 360102008830 putative metal binding site [ion binding]; other site 360102008831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 360102008832 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 360102008833 ApbE family; Region: ApbE; pfam02424 360102008834 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 360102008835 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 360102008836 catalytic loop [active] 360102008837 iron binding site [ion binding]; other site 360102008838 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 360102008839 FAD binding pocket [chemical binding]; other site 360102008840 FAD binding motif [chemical binding]; other site 360102008841 phosphate binding motif [ion binding]; other site 360102008842 beta-alpha-beta structure motif; other site 360102008843 NAD binding pocket [chemical binding]; other site 360102008844 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 360102008845 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 360102008846 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 360102008847 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 360102008848 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 360102008849 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 360102008850 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 360102008851 E3 interaction surface; other site 360102008852 lipoyl attachment site [posttranslational modification]; other site 360102008853 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 360102008854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 360102008855 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 360102008856 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 360102008857 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 360102008858 putative active site [active] 360102008859 putative dimer interface [polypeptide binding]; other site 360102008860 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 360102008861 dimer interface [polypeptide binding]; other site 360102008862 active site 360102008863 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 360102008864 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 360102008865 active site 360102008866 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 360102008867 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 360102008868 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 360102008869 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 360102008870 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 360102008871 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 360102008872 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 360102008873 allantoate amidohydrolase; Reviewed; Region: PRK09290 360102008874 active site 360102008875 metal binding site [ion binding]; metal-binding site 360102008876 dimer interface [polypeptide binding]; other site 360102008877 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360102008878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102008879 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102008880 DNA-binding interface [nucleotide binding]; DNA binding site 360102008881 Integrase core domain; Region: rve; pfam00665 360102008882 transposase/IS protein; Provisional; Region: PRK09183 360102008883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102008884 Walker A motif; other site 360102008885 ATP binding site [chemical binding]; other site 360102008886 Walker B motif; other site 360102008887 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 360102008888 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102008889 catalytic residue [active] 360102008890 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 360102008891 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 360102008892 Walker A/P-loop; other site 360102008893 ATP binding site [chemical binding]; other site 360102008894 Q-loop/lid; other site 360102008895 ABC transporter signature motif; other site 360102008896 Walker B; other site 360102008897 D-loop; other site 360102008898 H-loop/switch region; other site 360102008899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102008900 dimer interface [polypeptide binding]; other site 360102008901 conserved gate region; other site 360102008902 putative PBP binding loops; other site 360102008903 ABC-ATPase subunit interface; other site 360102008904 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360102008905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102008906 dimer interface [polypeptide binding]; other site 360102008907 conserved gate region; other site 360102008908 putative PBP binding loops; other site 360102008909 ABC-ATPase subunit interface; other site 360102008910 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 360102008911 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102008912 substrate binding pocket [chemical binding]; other site 360102008913 membrane-bound complex binding site; other site 360102008914 hinge residues; other site 360102008915 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 360102008916 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 360102008917 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 360102008918 putative active site [active] 360102008919 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 360102008920 amidase; Provisional; Region: PRK09201 360102008921 Amidase; Region: Amidase; cl11426 360102008922 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 360102008923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102008924 putative substrate translocation pore; other site 360102008925 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 360102008926 putative L-valine exporter; Provisional; Region: PRK10408 360102008927 transcriptional repressor MprA; Provisional; Region: PRK10870 360102008928 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 360102008929 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 360102008930 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102008931 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102008932 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 360102008933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102008934 putative substrate translocation pore; other site 360102008935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102008936 putative methyltransferase; Provisional; Region: PRK10864 360102008937 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 360102008938 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 360102008939 thioredoxin 2; Provisional; Region: PRK10996 360102008940 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 360102008941 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 360102008942 catalytic residues [active] 360102008943 Uncharacterized conserved protein [Function unknown]; Region: COG3148 360102008944 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 360102008945 CoA binding domain; Region: CoA_binding_2; pfam13380 360102008946 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 360102008947 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 360102008948 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 360102008949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360102008950 Coenzyme A binding pocket [chemical binding]; other site 360102008951 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 360102008952 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 360102008953 domain interface [polypeptide binding]; other site 360102008954 putative active site [active] 360102008955 catalytic site [active] 360102008956 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 360102008957 domain interface [polypeptide binding]; other site 360102008958 putative active site [active] 360102008959 catalytic site [active] 360102008960 lipoprotein; Provisional; Region: PRK10759 360102008961 protein disaggregation chaperone; Provisional; Region: PRK10865 360102008962 Clp amino terminal domain; Region: Clp_N; pfam02861 360102008963 Clp amino terminal domain; Region: Clp_N; pfam02861 360102008964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102008965 Walker A motif; other site 360102008966 ATP binding site [chemical binding]; other site 360102008967 Walker B motif; other site 360102008968 arginine finger; other site 360102008969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102008970 Walker A motif; other site 360102008971 ATP binding site [chemical binding]; other site 360102008972 Walker B motif; other site 360102008973 arginine finger; other site 360102008974 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 360102008975 hypothetical protein; Provisional; Region: PRK10723 360102008976 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 360102008977 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 360102008978 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360102008979 RNA binding surface [nucleotide binding]; other site 360102008980 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 360102008981 active site 360102008982 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 360102008983 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 360102008984 30S subunit binding site; other site 360102008985 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102008986 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102008987 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 360102008988 Prephenate dehydratase; Region: PDT; pfam00800 360102008989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102008990 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102008991 DNA-binding interface [nucleotide binding]; DNA binding site 360102008992 Integrase core domain; Region: rve; pfam00665 360102008993 transposase/IS protein; Provisional; Region: PRK09183 360102008994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102008995 Walker A motif; other site 360102008996 ATP binding site [chemical binding]; other site 360102008997 Walker B motif; other site 360102008998 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 360102008999 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 360102009000 active site 360102009001 SAM binding site [chemical binding]; other site 360102009002 homodimer interface [polypeptide binding]; other site 360102009003 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 360102009004 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 360102009005 Active Sites [active] 360102009006 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 360102009007 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 360102009008 CysD dimerization site [polypeptide binding]; other site 360102009009 G1 box; other site 360102009010 putative GEF interaction site [polypeptide binding]; other site 360102009011 GTP/Mg2+ binding site [chemical binding]; other site 360102009012 Switch I region; other site 360102009013 G2 box; other site 360102009014 G3 box; other site 360102009015 Switch II region; other site 360102009016 G4 box; other site 360102009017 G5 box; other site 360102009018 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 360102009019 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 360102009020 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 360102009021 ligand-binding site [chemical binding]; other site 360102009022 hypothetical protein; Provisional; Region: PRK10726 360102009023 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 360102009024 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 360102009025 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 360102009026 substrate binding site; other site 360102009027 dimer interface; other site 360102009028 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 360102009029 homotrimer interaction site [polypeptide binding]; other site 360102009030 zinc binding site [ion binding]; other site 360102009031 CDP-binding sites; other site 360102009032 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 360102009033 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 360102009034 Permutation of conserved domain; other site 360102009035 active site 360102009036 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 360102009037 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 360102009038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102009039 S-adenosylmethionine binding site [chemical binding]; other site 360102009040 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 360102009041 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360102009042 Peptidase family M23; Region: Peptidase_M23; pfam01551 360102009043 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 360102009044 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 360102009045 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360102009046 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 360102009047 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360102009048 DNA binding residues [nucleotide binding] 360102009049 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 360102009050 MutS domain I; Region: MutS_I; pfam01624 360102009051 MutS domain II; Region: MutS_II; pfam05188 360102009052 MutS domain III; Region: MutS_III; pfam05192 360102009053 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 360102009054 Walker A/P-loop; other site 360102009055 ATP binding site [chemical binding]; other site 360102009056 Q-loop/lid; other site 360102009057 ABC transporter signature motif; other site 360102009058 Walker B; other site 360102009059 D-loop; other site 360102009060 H-loop/switch region; other site 360102009061 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 360102009062 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 360102009063 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 360102009064 putative NAD(P) binding site [chemical binding]; other site 360102009065 catalytic Zn binding site [ion binding]; other site 360102009066 structural Zn binding site [ion binding]; other site 360102009067 short chain dehydrogenase; Provisional; Region: PRK06841 360102009068 classical (c) SDRs; Region: SDR_c; cd05233 360102009069 NAD(P) binding site [chemical binding]; other site 360102009070 active site 360102009071 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 360102009072 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 360102009073 DAK2 domain; Region: Dak2; pfam02734 360102009074 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 360102009075 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102009076 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 360102009077 arsenical pump membrane protein; Provisional; Region: PRK15445 360102009078 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 360102009079 transmembrane helices; other site 360102009080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 360102009081 dimerization interface [polypeptide binding]; other site 360102009082 putative DNA binding site [nucleotide binding]; other site 360102009083 putative Zn2+ binding site [ion binding]; other site 360102009084 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 360102009085 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102009086 substrate binding pocket [chemical binding]; other site 360102009087 membrane-bound complex binding site; other site 360102009088 hinge residues; other site 360102009089 Haem-binding domain; Region: Haem_bd; pfam14376 360102009090 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 360102009091 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 360102009092 N-terminal plug; other site 360102009093 ligand-binding site [chemical binding]; other site 360102009094 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 360102009095 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 360102009096 Yersinia protein of unknown function (DUF3831); Region: DUF3831; pfam12908 360102009097 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 360102009098 active site 360102009099 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 360102009100 fumarate hydratase; Provisional; Region: PRK15389 360102009101 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 360102009102 Fumarase C-terminus; Region: Fumerase_C; pfam05683 360102009103 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 360102009104 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 360102009105 putative N- and C-terminal domain interface [polypeptide binding]; other site 360102009106 putative active site [active] 360102009107 MgATP binding site [chemical binding]; other site 360102009108 catalytic site [active] 360102009109 metal binding site [ion binding]; metal-binding site 360102009110 putative xylulose binding site [chemical binding]; other site 360102009111 Putative L-xylulose-5-phosphate 3-epimerase [Carbohydrate transport and metabolism]; Region: SgaU; COG3623 360102009112 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 360102009113 AP (apurinic/apyrimidinic) site pocket; other site 360102009114 DNA interaction; other site 360102009115 Metal-binding active site; metal-binding site 360102009116 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102009117 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102009118 TM-ABC transporter signature motif; other site 360102009119 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102009120 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102009121 TM-ABC transporter signature motif; other site 360102009122 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360102009123 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102009124 Walker A/P-loop; other site 360102009125 ATP binding site [chemical binding]; other site 360102009126 Q-loop/lid; other site 360102009127 ABC transporter signature motif; other site 360102009128 Walker B; other site 360102009129 D-loop; other site 360102009130 H-loop/switch region; other site 360102009131 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102009132 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102009133 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 360102009134 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 360102009135 ligand binding site [chemical binding]; other site 360102009136 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 360102009137 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 360102009138 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 360102009139 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK13213 360102009140 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 360102009141 intersubunit interface [polypeptide binding]; other site 360102009142 active site 360102009143 Zn2+ binding site [ion binding]; other site 360102009144 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 360102009145 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 360102009146 putative [Fe4-S4] binding site [ion binding]; other site 360102009147 putative molybdopterin cofactor binding site [chemical binding]; other site 360102009148 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 360102009149 putative molybdopterin cofactor binding site; other site 360102009150 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 360102009151 4Fe-4S binding domain; Region: Fer4; cl02805 360102009152 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 360102009153 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 360102009154 cytochrome b561; Provisional; Region: PRK11513 360102009155 Soluble cytochrome b562 [Energy production and conversion]; Region: CybC; COG3783 360102009156 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 360102009157 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 360102009158 dimer interface [polypeptide binding]; other site 360102009159 active site 360102009160 heme binding site [chemical binding]; other site 360102009161 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 360102009162 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 360102009163 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 360102009164 ligand binding site [chemical binding]; other site 360102009165 dimerization interface [polypeptide binding]; other site 360102009166 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618 360102009167 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360102009168 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102009169 Walker A/P-loop; other site 360102009170 ATP binding site [chemical binding]; other site 360102009171 Q-loop/lid; other site 360102009172 ABC transporter signature motif; other site 360102009173 Walker B; other site 360102009174 D-loop; other site 360102009175 H-loop/switch region; other site 360102009176 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102009177 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102009178 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102009179 TM-ABC transporter signature motif; other site 360102009180 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 360102009181 TPP-binding site [chemical binding]; other site 360102009182 dimer interface [polypeptide binding]; other site 360102009183 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 360102009184 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 360102009185 PYR/PP interface [polypeptide binding]; other site 360102009186 dimer interface [polypeptide binding]; other site 360102009187 TPP binding site [chemical binding]; other site 360102009188 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 360102009189 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 360102009190 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 360102009191 N- and C-terminal domain interface [polypeptide binding]; other site 360102009192 active site 360102009193 MgATP binding site [chemical binding]; other site 360102009194 catalytic site [active] 360102009195 metal binding site [ion binding]; metal-binding site 360102009196 putative homotetramer interface [polypeptide binding]; other site 360102009197 putative homodimer interface [polypeptide binding]; other site 360102009198 glycerol binding site [chemical binding]; other site 360102009199 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 360102009200 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 360102009201 hexamer (dimer of trimers) interface [polypeptide binding]; other site 360102009202 substrate binding site [chemical binding]; other site 360102009203 trimer interface [polypeptide binding]; other site 360102009204 Mn binding site [ion binding]; other site 360102009205 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 360102009206 MarR family; Region: MarR_2; cl17246 360102009207 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 360102009208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102009209 putative MFS family transporter protein; Provisional; Region: PRK03633 360102009210 putative substrate translocation pore; other site 360102009211 hypothetical protein; Validated; Region: PRK03661 360102009212 recombinase A; Provisional; Region: recA; PRK09354 360102009213 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 360102009214 hexamer interface [polypeptide binding]; other site 360102009215 Walker A motif; other site 360102009216 ATP binding site [chemical binding]; other site 360102009217 Walker B motif; other site 360102009218 recombination regulator RecX; Reviewed; Region: recX; PRK00117 360102009219 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 360102009220 tRNA synthetases class II (A); Region: tRNA-synt_2c; pfam01411 360102009221 motif 1; other site 360102009222 active site 360102009223 motif 2; other site 360102009224 motif 3; other site 360102009225 alanine-tRNA ligase; Region: PLN02961 360102009226 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 360102009227 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 360102009228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102009229 motif II; other site 360102009230 Predicted membrane protein [Function unknown]; Region: COG1238 360102009231 glutamate--cysteine ligase; Provisional; Region: PRK02107 360102009232 S-ribosylhomocysteinase; Provisional; Region: PRK02260 360102009233 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102009234 hypothetical protein; Provisional; Region: PRK11573 360102009235 Domain of unknown function DUF21; Region: DUF21; pfam01595 360102009236 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 360102009237 Transporter associated domain; Region: CorC_HlyC; smart01091 360102009238 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 360102009239 signal recognition particle protein; Provisional; Region: PRK10867 360102009240 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 360102009241 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 360102009242 P loop; other site 360102009243 GTP binding site [chemical binding]; other site 360102009244 Signal peptide binding domain; Region: SRP_SPB; pfam02978 360102009245 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 360102009246 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 360102009247 RimM N-terminal domain; Region: RimM; pfam01782 360102009248 PRC-barrel domain; Region: PRC; pfam05239 360102009249 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 360102009250 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 360102009251 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102009252 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 360102009253 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 360102009254 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 360102009255 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 360102009256 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 360102009257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102009258 active site 360102009259 phosphorylation site [posttranslational modification] 360102009260 intermolecular recognition site; other site 360102009261 dimerization interface [polypeptide binding]; other site 360102009262 LytTr DNA-binding domain; Region: LytTR; pfam04397 360102009263 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 360102009264 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 360102009265 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 360102009266 Chorismate mutase type II; Region: CM_2; cl00693 360102009267 prephenate dehydrogenase; Validated; Region: PRK08507 360102009268 Prephenate dehydratase; Region: PDT; pfam00800 360102009269 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 360102009270 putative L-Phe binding site [chemical binding]; other site 360102009271 transposase/IS protein; Provisional; Region: PRK09183 360102009272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102009273 Walker A motif; other site 360102009274 ATP binding site [chemical binding]; other site 360102009275 Walker B motif; other site 360102009276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102009277 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102009278 DNA-binding interface [nucleotide binding]; DNA binding site 360102009279 Integrase core domain; Region: rve; pfam00665 360102009280 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 360102009281 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 360102009282 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 360102009283 YcfA-like protein; Region: YcfA; pfam07927 360102009284 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 360102009285 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 360102009286 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 360102009287 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 360102009288 sulfite reductase subunit beta; Provisional; Region: PRK13504 360102009289 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 360102009290 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 360102009291 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 360102009292 Flavodoxin; Region: Flavodoxin_1; pfam00258 360102009293 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 360102009294 FAD binding pocket [chemical binding]; other site 360102009295 FAD binding motif [chemical binding]; other site 360102009296 catalytic residues [active] 360102009297 NAD binding pocket [chemical binding]; other site 360102009298 phosphate binding motif [ion binding]; other site 360102009299 beta-alpha-beta structure motif; other site 360102009300 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 360102009301 active site 360102009302 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 360102009303 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 360102009304 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 360102009305 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 360102009306 E-class dimer interface [polypeptide binding]; other site 360102009307 P-class dimer interface [polypeptide binding]; other site 360102009308 active site 360102009309 Cu2+ binding site [ion binding]; other site 360102009310 Zn2+ binding site [ion binding]; other site 360102009311 enolase; Provisional; Region: eno; PRK00077 360102009312 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 360102009313 dimer interface [polypeptide binding]; other site 360102009314 metal binding site [ion binding]; metal-binding site 360102009315 substrate binding pocket [chemical binding]; other site 360102009316 CTP synthetase; Validated; Region: pyrG; PRK05380 360102009317 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 360102009318 Catalytic site [active] 360102009319 active site 360102009320 UTP binding site [chemical binding]; other site 360102009321 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 360102009322 active site 360102009323 putative oxyanion hole; other site 360102009324 catalytic triad [active] 360102009325 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 360102009326 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 360102009327 homodimer interface [polypeptide binding]; other site 360102009328 metal binding site [ion binding]; metal-binding site 360102009329 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 360102009330 homodimer interface [polypeptide binding]; other site 360102009331 active site 360102009332 putative chemical substrate binding site [chemical binding]; other site 360102009333 metal binding site [ion binding]; metal-binding site 360102009334 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 360102009335 HD domain; Region: HD_4; pfam13328 360102009336 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 360102009337 synthetase active site [active] 360102009338 NTP binding site [chemical binding]; other site 360102009339 metal binding site [ion binding]; metal-binding site 360102009340 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 360102009341 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 360102009342 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 360102009343 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 360102009344 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 360102009345 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102009346 dimerization interface [polypeptide binding]; other site 360102009347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102009348 dimer interface [polypeptide binding]; other site 360102009349 phosphorylation site [posttranslational modification] 360102009350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102009351 ATP binding site [chemical binding]; other site 360102009352 Mg2+ binding site [ion binding]; other site 360102009353 G-X-G motif; other site 360102009354 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 360102009355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102009356 active site 360102009357 phosphorylation site [posttranslational modification] 360102009358 intermolecular recognition site; other site 360102009359 dimerization interface [polypeptide binding]; other site 360102009360 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 360102009361 putative binding surface; other site 360102009362 active site 360102009363 serine endoprotease; Provisional; Region: PRK10942 360102009364 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 360102009365 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360102009366 protein binding site [polypeptide binding]; other site 360102009367 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360102009368 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 360102009369 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360102009370 Zn2+ binding site [ion binding]; other site 360102009371 Mg2+ binding site [ion binding]; other site 360102009372 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 360102009373 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 360102009374 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 360102009375 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 360102009376 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 360102009377 cobalamin binding residues [chemical binding]; other site 360102009378 putative BtuC binding residues; other site 360102009379 dimer interface [polypeptide binding]; other site 360102009380 hypothetical protein; Provisional; Region: PRK10578 360102009381 UPF0126 domain; Region: UPF0126; pfam03458 360102009382 UPF0126 domain; Region: UPF0126; pfam03458 360102009383 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 360102009384 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 360102009385 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 360102009386 Cl- selectivity filter; other site 360102009387 Cl- binding residues [ion binding]; other site 360102009388 pore gating glutamate residue; other site 360102009389 dimer interface [polypeptide binding]; other site 360102009390 H+/Cl- coupling transport residue; other site 360102009391 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 360102009392 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360102009393 inhibitor-cofactor binding pocket; inhibition site 360102009394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102009395 catalytic residue [active] 360102009396 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 360102009397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102009398 ABC-ATPase subunit interface; other site 360102009399 dimer interface [polypeptide binding]; other site 360102009400 putative PBP binding regions; other site 360102009401 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102009402 ABC-ATPase subunit interface; other site 360102009403 dimer interface [polypeptide binding]; other site 360102009404 putative PBP binding regions; other site 360102009405 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 360102009406 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 360102009407 siderophore binding site; other site 360102009408 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 360102009409 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360102009410 Walker A/P-loop; other site 360102009411 ATP binding site [chemical binding]; other site 360102009412 Q-loop/lid; other site 360102009413 ABC transporter signature motif; other site 360102009414 Walker B; other site 360102009415 D-loop; other site 360102009416 H-loop/switch region; other site 360102009417 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 360102009418 Transglycosylase; Region: Transgly; pfam00912 360102009419 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 360102009420 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 360102009421 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360102009422 ATP binding site [chemical binding]; other site 360102009423 putative Mg++ binding site [ion binding]; other site 360102009424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102009425 nucleotide binding region [chemical binding]; other site 360102009426 ATP-binding site [chemical binding]; other site 360102009427 Helicase associated domain (HA2); Region: HA2; pfam04408 360102009428 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 360102009429 2'-5' RNA ligase; Provisional; Region: PRK15124 360102009430 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 360102009431 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 360102009432 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 360102009433 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 360102009434 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 360102009435 active site 360102009436 nucleotide binding site [chemical binding]; other site 360102009437 HIGH motif; other site 360102009438 KMSKS motif; other site 360102009439 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 360102009440 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 360102009441 active site 360102009442 NTP binding site [chemical binding]; other site 360102009443 metal binding triad [ion binding]; metal-binding site 360102009444 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 360102009445 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 360102009446 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 360102009447 catalytic center binding site [active] 360102009448 ATP binding site [chemical binding]; other site 360102009449 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 360102009450 oligomerization interface [polypeptide binding]; other site 360102009451 active site 360102009452 metal binding site [ion binding]; metal-binding site 360102009453 pantoate--beta-alanine ligase; Region: panC; TIGR00018 360102009454 Pantoate-beta-alanine ligase; Region: PanC; cd00560 360102009455 active site 360102009456 ATP-binding site [chemical binding]; other site 360102009457 pantoate-binding site; other site 360102009458 HXXH motif; other site 360102009459 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 360102009460 tetramerization interface [polypeptide binding]; other site 360102009461 active site 360102009462 Bacterial SH3 domain; Region: SH3_3; cl17532 360102009463 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 360102009464 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 360102009465 putative active site [active] 360102009466 putative metal binding site [ion binding]; other site 360102009467 inner membrane transport permease; Provisional; Region: PRK15066 360102009468 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 360102009469 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 360102009470 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 360102009471 Walker A/P-loop; other site 360102009472 ATP binding site [chemical binding]; other site 360102009473 Q-loop/lid; other site 360102009474 ABC transporter signature motif; other site 360102009475 Walker B; other site 360102009476 D-loop; other site 360102009477 H-loop/switch region; other site 360102009478 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 360102009479 active site clefts [active] 360102009480 zinc binding site [ion binding]; other site 360102009481 dimer interface [polypeptide binding]; other site 360102009482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360102009483 active site 360102009484 multicopper oxidase; Provisional; Region: PRK10965 360102009485 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 360102009486 Multicopper oxidase; Region: Cu-oxidase; pfam00394 360102009487 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 360102009488 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 360102009489 spermidine synthase; Provisional; Region: PRK00811 360102009490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102009491 S-adenosylmethionine binding site [chemical binding]; other site 360102009492 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 360102009493 aromatic amino acid exporter; Provisional; Region: PRK11689 360102009494 EamA-like transporter family; Region: EamA; cl17759 360102009495 hypothetical protein; Provisional; Region: PRK05248 360102009496 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 360102009497 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 360102009498 substrate binding site [chemical binding]; other site 360102009499 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 360102009500 substrate binding site [chemical binding]; other site 360102009501 ligand binding site [chemical binding]; other site 360102009502 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102009503 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 360102009504 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360102009505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360102009506 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360102009507 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 360102009508 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 360102009509 E3 interaction surface; other site 360102009510 lipoyl attachment site [posttranslational modification]; other site 360102009511 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 360102009512 E3 interaction surface; other site 360102009513 lipoyl attachment site [posttranslational modification]; other site 360102009514 e3 binding domain; Region: E3_binding; pfam02817 360102009515 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 360102009516 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 360102009517 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 360102009518 dimer interface [polypeptide binding]; other site 360102009519 TPP-binding site [chemical binding]; other site 360102009520 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 360102009521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360102009522 DNA-binding site [nucleotide binding]; DNA binding site 360102009523 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 360102009524 aromatic amino acid transporter; Provisional; Region: PRK10238 360102009525 regulatory protein AmpE; Provisional; Region: PRK10987 360102009526 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 360102009527 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 360102009528 amidase catalytic site [active] 360102009529 Zn binding residues [ion binding]; other site 360102009530 substrate binding site [chemical binding]; other site 360102009531 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 360102009532 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 360102009533 dimerization interface [polypeptide binding]; other site 360102009534 active site 360102009535 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 360102009536 putative major pilin subunit; Provisional; Region: PRK10574 360102009537 hypothetical protein; Provisional; Region: PRK10436 360102009538 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 360102009539 Walker A motif; other site 360102009540 ATP binding site [chemical binding]; other site 360102009541 Walker B motif; other site 360102009542 type IV pilin biogenesis protein; Provisional; Region: PRK10573 360102009543 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 360102009544 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 360102009545 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 360102009546 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 360102009547 active site 360102009548 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 360102009549 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 360102009550 CoA-binding site [chemical binding]; other site 360102009551 ATP-binding [chemical binding]; other site 360102009552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 360102009553 DNA gyrase inhibitor; Reviewed; Region: PRK00418 360102009554 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102009555 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102009556 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102009557 DNA-binding interface [nucleotide binding]; DNA binding site 360102009558 Integrase core domain; Region: rve; pfam00665 360102009559 transposase/IS protein; Provisional; Region: PRK09183 360102009560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102009561 Walker A motif; other site 360102009562 ATP binding site [chemical binding]; other site 360102009563 Walker B motif; other site 360102009564 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 360102009565 Mg2+ binding site [ion binding]; other site 360102009566 G-X-G motif; other site 360102009567 Uncharacterized conserved protein [Function unknown]; Region: COG1479 360102009568 Protein of unknown function DUF262; Region: DUF262; pfam03235 360102009569 Protein of unknown function DUF262; Region: DUF262; pfam03235 360102009570 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 360102009571 integrase; Provisional; Region: PRK09692 360102009572 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 360102009573 active site 360102009574 Int/Topo IB signature motif; other site 360102009575 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 360102009576 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 360102009577 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 360102009578 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 360102009579 multifunctional aminopeptidase A; Provisional; Region: PRK00913 360102009580 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 360102009581 interface (dimer of trimers) [polypeptide binding]; other site 360102009582 Substrate-binding/catalytic site; other site 360102009583 Zn-binding sites [ion binding]; other site 360102009584 DNA polymerase III subunit chi; Validated; Region: PRK05728 360102009585 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 360102009586 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 360102009587 HIGH motif; other site 360102009588 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 360102009589 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 360102009590 active site 360102009591 KMSKS motif; other site 360102009592 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 360102009593 tRNA binding surface [nucleotide binding]; other site 360102009594 anticodon binding site; other site 360102009595 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 360102009596 RNase E inhibitor protein; Provisional; Region: PRK11191 360102009597 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 360102009598 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 360102009599 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 360102009600 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 360102009601 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 360102009602 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 360102009603 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 360102009604 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 360102009605 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 360102009606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102009607 dimer interface [polypeptide binding]; other site 360102009608 conserved gate region; other site 360102009609 putative PBP binding loops; other site 360102009610 ABC-ATPase subunit interface; other site 360102009611 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 360102009612 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 360102009613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102009614 dimer interface [polypeptide binding]; other site 360102009615 conserved gate region; other site 360102009616 ABC-ATPase subunit interface; other site 360102009617 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102009618 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 360102009619 Walker A/P-loop; other site 360102009620 ATP binding site [chemical binding]; other site 360102009621 Q-loop/lid; other site 360102009622 ABC transporter signature motif; other site 360102009623 Walker B; other site 360102009624 D-loop; other site 360102009625 H-loop/switch region; other site 360102009626 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 360102009627 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102009628 Walker A/P-loop; other site 360102009629 ATP binding site [chemical binding]; other site 360102009630 Q-loop/lid; other site 360102009631 ABC transporter signature motif; other site 360102009632 Walker B; other site 360102009633 D-loop; other site 360102009634 H-loop/switch region; other site 360102009635 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 360102009636 ATP cone domain; Region: ATP-cone; pfam03477 360102009637 Class III ribonucleotide reductase; Region: RNR_III; cd01675 360102009638 effector binding site; other site 360102009639 active site 360102009640 Zn binding site [ion binding]; other site 360102009641 glycine loop; other site 360102009642 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 360102009643 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 360102009644 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 360102009645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360102009646 DNA-binding site [nucleotide binding]; DNA binding site 360102009647 UTRA domain; Region: UTRA; pfam07702 360102009648 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnG; COG3624 360102009649 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 360102009650 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 360102009651 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 360102009652 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 360102009653 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102009654 Walker A/P-loop; other site 360102009655 ATP binding site [chemical binding]; other site 360102009656 Q-loop/lid; other site 360102009657 ABC transporter signature motif; other site 360102009658 Walker B; other site 360102009659 D-loop; other site 360102009660 H-loop/switch region; other site 360102009661 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 360102009662 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 360102009663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102009664 Walker A/P-loop; other site 360102009665 ATP binding site [chemical binding]; other site 360102009666 Q-loop/lid; other site 360102009667 ABC transporter signature motif; other site 360102009668 Walker B; other site 360102009669 D-loop; other site 360102009670 H-loop/switch region; other site 360102009671 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 360102009672 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 360102009673 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 360102009674 active site 360102009675 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 360102009676 Guanylate kinase; Region: Guanylate_kin; pfam00625 360102009677 active site 360102009678 putative hydrolase; Provisional; Region: PRK02113 360102009679 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 360102009680 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 360102009681 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 360102009682 NAD binding site [chemical binding]; other site 360102009683 active site 360102009684 hypothetical protein; Provisional; Region: PRK03467 360102009685 Alginate lyase; Region: Alginate_lyase; pfam05426 360102009686 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 360102009687 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 360102009688 Walker A/P-loop; other site 360102009689 ATP binding site [chemical binding]; other site 360102009690 Q-loop/lid; other site 360102009691 ABC transporter signature motif; other site 360102009692 Walker B; other site 360102009693 D-loop; other site 360102009694 H-loop/switch region; other site 360102009695 TOBE domain; Region: TOBE_2; pfam08402 360102009696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360102009697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102009698 dimer interface [polypeptide binding]; other site 360102009699 conserved gate region; other site 360102009700 putative PBP binding loops; other site 360102009701 ABC-ATPase subunit interface; other site 360102009702 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 360102009703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102009704 dimer interface [polypeptide binding]; other site 360102009705 putative PBP binding loops; other site 360102009706 ABC-ATPase subunit interface; other site 360102009707 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360102009708 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 360102009709 Alginate lyase; Region: Alginate_lyase; pfam05426 360102009710 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 360102009711 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 360102009712 GIY-YIG motif/motif A; other site 360102009713 putative active site [active] 360102009714 putative metal binding site [ion binding]; other site 360102009715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360102009716 Coenzyme A binding pocket [chemical binding]; other site 360102009717 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 360102009718 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 360102009719 Peptidase family U32; Region: Peptidase_U32; pfam01136 360102009720 putative protease; Provisional; Region: PRK15447 360102009721 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 360102009722 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 360102009723 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 360102009724 Protein export membrane protein; Region: SecD_SecF; cl14618 360102009725 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 360102009726 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102009727 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102009728 hypothetical protein; Provisional; Region: PRK10508 360102009729 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 360102009730 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 360102009731 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 360102009732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360102009733 non-specific DNA binding site [nucleotide binding]; other site 360102009734 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 360102009735 salt bridge; other site 360102009736 sequence-specific DNA binding site [nucleotide binding]; other site 360102009737 Phage-related protein [Function unknown]; Region: COG4679 360102009738 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 360102009739 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 360102009740 ATP binding site [chemical binding]; other site 360102009741 Mg++ binding site [ion binding]; other site 360102009742 motif III; other site 360102009743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102009744 nucleotide binding region [chemical binding]; other site 360102009745 ATP-binding site [chemical binding]; other site 360102009746 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 360102009747 putative RNA binding site [nucleotide binding]; other site 360102009748 Cold shock protein DEAD box A; Region: DEADboxA; pfam12343 360102009749 lipoprotein NlpI; Provisional; Region: PRK11189 360102009750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 360102009751 binding surface 360102009752 TPR motif; other site 360102009753 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 360102009754 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 360102009755 RNase E interface [polypeptide binding]; other site 360102009756 trimer interface [polypeptide binding]; other site 360102009757 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 360102009758 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 360102009759 RNase E interface [polypeptide binding]; other site 360102009760 trimer interface [polypeptide binding]; other site 360102009761 active site 360102009762 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 360102009763 putative nucleic acid binding region [nucleotide binding]; other site 360102009764 G-X-X-G motif; other site 360102009765 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 360102009766 RNA binding site [nucleotide binding]; other site 360102009767 domain interface; other site 360102009768 putative transposase OrfB; Reviewed; Region: PHA02517 360102009769 HTH-like domain; Region: HTH_21; pfam13276 360102009770 Integrase core domain; Region: rve; pfam00665 360102009771 Integrase core domain; Region: rve_2; pfam13333 360102009772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 360102009773 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102009774 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102009775 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 360102009776 ornithine cyclodeaminase; Validated; Region: PRK06823 360102009777 hypothetical protein; Provisional; Region: PRK06815 360102009778 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 360102009779 tetramer interface [polypeptide binding]; other site 360102009780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102009781 catalytic residue [active] 360102009782 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 360102009783 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 360102009784 hypothetical protein; Provisional; Region: PRK11616 360102009785 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 360102009786 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 360102009787 putative dimer interface [polypeptide binding]; other site 360102009788 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 360102009789 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 360102009790 putative dimer interface [polypeptide binding]; other site 360102009791 putative transporter; Validated; Region: PRK03818 360102009792 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 360102009793 TrkA-C domain; Region: TrkA_C; pfam02080 360102009794 TrkA-C domain; Region: TrkA_C; pfam02080 360102009795 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 360102009796 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 360102009797 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360102009798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102009799 homodimer interface [polypeptide binding]; other site 360102009800 catalytic residue [active] 360102009801 alpha-amylase; Reviewed; Region: malS; PRK09505 360102009802 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 360102009803 active site 360102009804 catalytic site [active] 360102009805 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 360102009806 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 360102009807 dimerization interface [polypeptide binding]; other site 360102009808 ligand binding site [chemical binding]; other site 360102009809 NADP binding site [chemical binding]; other site 360102009810 catalytic site [active] 360102009811 Predicted transcriptional regulator [Transcription]; Region: COG2345 360102009812 putative outer membrane lipoprotein; Provisional; Region: PRK10510 360102009813 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360102009814 ligand binding site [chemical binding]; other site 360102009815 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 360102009816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360102009817 Coenzyme A binding pocket [chemical binding]; other site 360102009818 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 360102009819 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 360102009820 dimer interface [polypeptide binding]; other site 360102009821 motif 1; other site 360102009822 active site 360102009823 motif 2; other site 360102009824 motif 3; other site 360102009825 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 360102009826 DALR anticodon binding domain; Region: DALR_1; pfam05746 360102009827 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 360102009828 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 360102009829 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 360102009830 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 360102009831 active site 360102009832 P-loop; other site 360102009833 phosphorylation site [posttranslational modification] 360102009834 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 360102009835 active site 360102009836 phosphorylation site [posttranslational modification] 360102009837 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 360102009838 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 360102009839 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 360102009840 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 360102009841 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 360102009842 hypothetical protein; Provisional; Region: PRK11020 360102009843 Electron transfer DM13; Region: DM13; pfam10517 360102009844 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 360102009845 dimer interface [polypeptide binding]; other site 360102009846 putative CheW interface [polypeptide binding]; other site 360102009847 transposase/IS protein; Provisional; Region: PRK09183 360102009848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102009849 Walker A motif; other site 360102009850 ATP binding site [chemical binding]; other site 360102009851 Walker B motif; other site 360102009852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102009853 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102009854 DNA-binding interface [nucleotide binding]; DNA binding site 360102009855 Integrase core domain; Region: rve; pfam00665 360102009856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102009857 dimerization interface [polypeptide binding]; other site 360102009858 superoxide dismutase; Provisional; Region: PRK10925 360102009859 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 360102009860 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 360102009861 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 360102009862 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 360102009863 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 360102009864 molybdopterin cofactor binding site; other site 360102009865 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 360102009866 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 360102009867 molybdopterin cofactor binding site; other site 360102009868 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 360102009869 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 360102009870 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 360102009871 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 360102009872 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 360102009873 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 360102009874 selenocysteine synthase; Provisional; Region: PRK04311 360102009875 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 360102009876 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 360102009877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102009878 catalytic residue [active] 360102009879 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 360102009880 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 360102009881 G1 box; other site 360102009882 putative GEF interaction site [polypeptide binding]; other site 360102009883 GTP/Mg2+ binding site [chemical binding]; other site 360102009884 Switch I region; other site 360102009885 G2 box; other site 360102009886 G3 box; other site 360102009887 Switch II region; other site 360102009888 G4 box; other site 360102009889 G5 box; other site 360102009890 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 360102009891 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 360102009892 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 360102009893 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 360102009894 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 360102009895 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 360102009896 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 360102009897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102009898 putative substrate translocation pore; other site 360102009899 putative transposase OrfB; Reviewed; Region: PHA02517 360102009900 HTH-like domain; Region: HTH_21; pfam13276 360102009901 Integrase core domain; Region: rve; pfam00665 360102009902 Integrase core domain; Region: rve_2; pfam13333 360102009903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 360102009904 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102009905 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102009906 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 360102009907 hypothetical protein; Validated; Region: PRK06778 360102009908 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 360102009909 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360102009910 ligand binding site [chemical binding]; other site 360102009911 flagellar motor protein MotA; Provisional; Region: PRK12482 360102009912 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 360102009913 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 360102009914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360102009915 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 360102009916 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360102009917 DNA binding residues [nucleotide binding] 360102009918 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 360102009919 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 360102009920 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 360102009921 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 360102009922 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 360102009923 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 360102009924 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 360102009925 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 360102009926 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 360102009927 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 360102009928 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 360102009929 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 360102009930 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 360102009931 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 360102009932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360102009933 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102009934 DNA binding site [nucleotide binding] 360102009935 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 360102009936 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 360102009937 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 360102009938 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 360102009939 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 360102009940 peptidoglycan hydrolase; Reviewed; Region: flgJ; PRK12708 360102009941 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 360102009942 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 360102009943 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 360102009944 Flagellar L-ring protein; Region: FlgH; pfam02107 360102009945 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 360102009946 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 360102009947 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 360102009948 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 360102009949 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 360102009950 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 360102009951 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 360102009952 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 360102009953 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 360102009954 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 360102009955 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 360102009956 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619 360102009957 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 360102009958 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 360102009959 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 360102009960 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 360102009961 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 360102009962 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 360102009963 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 360102009964 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 360102009965 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 360102009966 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 360102009967 FlgN protein; Region: FlgN; pfam05130 360102009968 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 360102009969 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 360102009970 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 360102009971 Walker A motif; other site 360102009972 ATP binding site [chemical binding]; other site 360102009973 Walker B motif; other site 360102009974 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 360102009975 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 360102009976 Flagellar assembly protein FliH; Region: FliH; pfam02108 360102009977 MgtE intracellular N domain; Region: MgtE_N; smart00924 360102009978 FliG C-terminal domain; Region: FliG_C; pfam01706 360102009979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102009980 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102009981 DNA-binding interface [nucleotide binding]; DNA binding site 360102009982 Integrase core domain; Region: rve; pfam00665 360102009983 transposase/IS protein; Provisional; Region: PRK09183 360102009984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102009985 Walker A motif; other site 360102009986 ATP binding site [chemical binding]; other site 360102009987 Walker B motif; other site 360102009988 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 360102009989 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 360102009990 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 360102009991 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 360102009992 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 360102009993 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 360102009994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102009995 Walker A motif; other site 360102009996 ATP binding site [chemical binding]; other site 360102009997 Walker B motif; other site 360102009998 arginine finger; other site 360102009999 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 360102010000 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 360102010001 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 360102010002 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 360102010003 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 360102010004 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 360102010005 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 360102010006 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 360102010007 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 360102010008 FHIPEP family; Region: FHIPEP; pfam00771 360102010009 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 360102010010 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 360102010011 ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592 360102010012 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 360102010013 siderophore binding site; other site 360102010014 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 360102010015 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 360102010016 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102010017 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 360102010018 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 360102010019 PapC N-terminal domain; Region: PapC_N; pfam13954 360102010020 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102010021 PapC C-terminal domain; Region: PapC_C; pfam13953 360102010022 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102010023 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 360102010024 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 360102010025 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 360102010026 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 360102010027 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 360102010028 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 360102010029 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 360102010030 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 360102010031 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 360102010032 ATP binding site [chemical binding]; other site 360102010033 Walker A motif; other site 360102010034 hexamer interface [polypeptide binding]; other site 360102010035 Walker B motif; other site 360102010036 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 360102010037 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 360102010038 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 360102010039 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 360102010040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 360102010041 binding surface 360102010042 TPR motif; other site 360102010043 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 360102010044 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 360102010045 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 360102010046 metal ion-dependent adhesion site (MIDAS); other site 360102010047 biopolymer transport protein ExbD; Provisional; Region: PRK11267 360102010048 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 360102010049 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 360102010050 cystathionine beta-lyase; Provisional; Region: PRK08114 360102010051 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360102010052 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102010053 catalytic residue [active] 360102010054 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360102010055 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 360102010056 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 360102010057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102010058 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 360102010059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102010060 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 360102010061 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 360102010062 dimer interface [polypeptide binding]; other site 360102010063 active site 360102010064 metal binding site [ion binding]; metal-binding site 360102010065 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 360102010066 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 360102010067 active site 360102010068 catalytic tetrad [active] 360102010069 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 360102010070 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 360102010071 FtsI repressor; Provisional; Region: PRK10883 360102010072 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 360102010073 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 360102010074 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 360102010075 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 360102010076 putative acyl-acceptor binding pocket; other site 360102010077 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 360102010078 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 360102010079 CAP-like domain; other site 360102010080 active site 360102010081 primary dimer interface [polypeptide binding]; other site 360102010082 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 360102010083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102010084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102010085 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360102010086 dimerization interface [polypeptide binding]; other site 360102010087 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 360102010088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102010089 ATP binding site [chemical binding]; other site 360102010090 Mg2+ binding site [ion binding]; other site 360102010091 G-X-G motif; other site 360102010092 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 360102010093 anchoring element; other site 360102010094 dimer interface [polypeptide binding]; other site 360102010095 ATP binding site [chemical binding]; other site 360102010096 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 360102010097 active site 360102010098 metal binding site [ion binding]; metal-binding site 360102010099 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 360102010100 esterase YqiA; Provisional; Region: PRK11071 360102010101 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 360102010102 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 360102010103 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 360102010104 hexamer interface [polypeptide binding]; other site 360102010105 cyclic 3',5'-adenosine monophosphate phosphodiesterase; Provisional; Region: PRK11148 360102010106 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 360102010107 putative dehydrogenase; Provisional; Region: PRK11039 360102010108 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 360102010109 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 360102010110 dimer interface [polypeptide binding]; other site 360102010111 ADP-ribose binding site [chemical binding]; other site 360102010112 active site 360102010113 nudix motif; other site 360102010114 metal binding site [ion binding]; metal-binding site 360102010115 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 360102010116 hypothetical protein; Provisional; Region: PRK11653 360102010117 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 360102010118 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 360102010119 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 360102010120 putative active site [active] 360102010121 metal binding site [ion binding]; metal-binding site 360102010122 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 360102010123 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 360102010124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 360102010125 putative transporter; Provisional; Region: PRK11021 360102010126 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 360102010127 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 360102010128 putative ribose interaction site [chemical binding]; other site 360102010129 putative ADP binding site [chemical binding]; other site 360102010130 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 360102010131 active site 360102010132 nucleotide binding site [chemical binding]; other site 360102010133 HIGH motif; other site 360102010134 KMSKS motif; other site 360102010135 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 360102010136 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 360102010137 metal binding triad; other site 360102010138 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 360102010139 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 360102010140 metal binding triad; other site 360102010141 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 360102010142 Uncharacterized conserved protein [Function unknown]; Region: COG3025 360102010143 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 360102010144 putative active site [active] 360102010145 putative metal binding residues [ion binding]; other site 360102010146 signature motif; other site 360102010147 putative triphosphate binding site [ion binding]; other site 360102010148 SH3 domain-containing protein; Provisional; Region: PRK10884 360102010149 Bacterial SH3 domain homologues; Region: SH3b; smart00287 360102010150 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 360102010151 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 360102010152 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 360102010153 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360102010154 Zn2+ binding site [ion binding]; other site 360102010155 Mg2+ binding site [ion binding]; other site 360102010156 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 360102010157 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 360102010158 homooctamer interface [polypeptide binding]; other site 360102010159 active site 360102010160 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 360102010161 UGMP family protein; Validated; Region: PRK09604 360102010162 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 360102010163 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 360102010164 DNA primase; Validated; Region: dnaG; PRK05667 360102010165 CHC2 zinc finger; Region: zf-CHC2; pfam01807 360102010166 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 360102010167 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 360102010168 active site 360102010169 metal binding site [ion binding]; metal-binding site 360102010170 interdomain interaction site; other site 360102010171 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 360102010172 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 360102010173 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 360102010174 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 360102010175 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 360102010176 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 360102010177 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 360102010178 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 360102010179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 360102010180 DNA binding residues [nucleotide binding] 360102010181 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 360102010182 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 360102010183 active site 360102010184 transposase/IS protein; Provisional; Region: PRK09183 360102010185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102010186 Walker A motif; other site 360102010187 ATP binding site [chemical binding]; other site 360102010188 Walker B motif; other site 360102010189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102010190 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102010191 DNA-binding interface [nucleotide binding]; DNA binding site 360102010192 Integrase core domain; Region: rve; pfam00665 360102010193 Fic/DOC family; Region: Fic; cl00960 360102010194 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102010195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102010196 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 360102010197 putative effector binding pocket; other site 360102010198 putative dimerization interface [polypeptide binding]; other site 360102010199 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 360102010200 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 360102010201 catalytic residues [active] 360102010202 putative monooxygenase; Provisional; Region: PRK11118 360102010203 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 360102010204 homotrimer interaction site [polypeptide binding]; other site 360102010205 putative active site [active] 360102010206 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 360102010207 homotrimer interaction site [polypeptide binding]; other site 360102010208 putative active site [active] 360102010209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 360102010210 YheO-like PAS domain; Region: PAS_6; pfam08348 360102010211 HTH domain; Region: HTH_22; pfam13309 360102010212 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 360102010213 putative hydrophobic ligand binding site [chemical binding]; other site 360102010214 protein interface [polypeptide binding]; other site 360102010215 gate; other site 360102010216 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 360102010217 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 360102010218 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360102010219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102010220 homodimer interface [polypeptide binding]; other site 360102010221 catalytic residue [active] 360102010222 multidrug resistance protein MdtN; Provisional; Region: PRK10476 360102010223 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102010224 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102010225 Predicted membrane protein [Function unknown]; Region: COG1289 360102010226 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 360102010227 Outer membrane efflux protein; Region: OEP; pfam02321 360102010228 Outer membrane efflux protein; Region: OEP; pfam02321 360102010229 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 360102010230 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 360102010231 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 360102010232 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 360102010233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102010234 dimer interface [polypeptide binding]; other site 360102010235 conserved gate region; other site 360102010236 putative PBP binding loops; other site 360102010237 ABC-ATPase subunit interface; other site 360102010238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102010239 dimer interface [polypeptide binding]; other site 360102010240 conserved gate region; other site 360102010241 putative PBP binding loops; other site 360102010242 ABC-ATPase subunit interface; other site 360102010243 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 360102010244 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 360102010245 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360102010246 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102010247 DNA binding site [nucleotide binding] 360102010248 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 360102010249 ligand binding site [chemical binding]; other site 360102010250 dimerization interface [polypeptide binding]; other site 360102010251 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 360102010252 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 360102010253 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 360102010254 Walker A/P-loop; other site 360102010255 ATP binding site [chemical binding]; other site 360102010256 Q-loop/lid; other site 360102010257 ABC transporter signature motif; other site 360102010258 Walker B; other site 360102010259 D-loop; other site 360102010260 H-loop/switch region; other site 360102010261 TOBE domain; Region: TOBE_2; pfam08402 360102010262 Putative glucoamylase; Region: Glycoamylase; pfam10091 360102010263 Autotransporter beta-domain; Region: Autotransporter; smart00869 360102010264 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 360102010265 V-type ATP synthase subunit E; Provisional; Region: PRK02292 360102010266 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102010267 haemagglutination activity domain; Region: Haemagg_act; pfam05860 360102010268 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 360102010269 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102010270 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102010271 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 360102010272 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 360102010273 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 360102010274 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 360102010275 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 360102010276 metal ion-dependent adhesion site (MIDAS); other site 360102010277 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 360102010278 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 360102010279 putative metal binding site [ion binding]; other site 360102010280 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 360102010281 metal ion-dependent adhesion site (MIDAS); other site 360102010282 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 360102010283 metal ion-dependent adhesion site (MIDAS); other site 360102010284 Protein phosphatase 2C; Region: PP2C_2; pfam13672 360102010285 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 360102010286 substrate binding site [chemical binding]; other site 360102010287 activation loop (A-loop); other site 360102010288 acid-resistance membrane protein; Provisional; Region: PRK10209 360102010289 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 360102010290 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 360102010291 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 360102010292 active site 360102010293 FMN binding site [chemical binding]; other site 360102010294 2,4-decadienoyl-CoA binding site; other site 360102010295 catalytic residue [active] 360102010296 4Fe-4S cluster binding site [ion binding]; other site 360102010297 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 360102010298 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 360102010299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102010300 S-adenosylmethionine binding site [chemical binding]; other site 360102010301 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 360102010302 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 360102010303 Autotransporter beta-domain; Region: Autotransporter; pfam03797 360102010304 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 360102010305 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360102010306 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360102010307 serine/threonine transporter SstT; Provisional; Region: PRK13628 360102010308 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 360102010309 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102010310 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 360102010311 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 360102010312 galactarate dehydratase; Region: galactar-dH20; TIGR03248 360102010313 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 360102010314 altronate oxidoreductase; Provisional; Region: PRK03643 360102010315 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 360102010316 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 360102010317 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 360102010318 Glucuronate isomerase; Region: UxaC; pfam02614 360102010319 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 360102010320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102010321 D-galactonate transporter; Region: 2A0114; TIGR00893 360102010322 putative substrate translocation pore; other site 360102010323 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 360102010324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360102010325 DNA-binding site [nucleotide binding]; DNA binding site 360102010326 FCD domain; Region: FCD; pfam07729 360102010327 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 360102010328 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360102010329 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 360102010330 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 360102010331 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 360102010332 Predicted membrane protein [Function unknown]; Region: COG5393 360102010333 YqjK-like protein; Region: YqjK; pfam13997 360102010334 Predicted membrane protein [Function unknown]; Region: COG2259 360102010335 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 360102010336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102010337 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102010338 DNA-binding interface [nucleotide binding]; DNA binding site 360102010339 Integrase core domain; Region: rve; pfam00665 360102010340 transposase/IS protein; Provisional; Region: PRK09183 360102010341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102010342 Walker A motif; other site 360102010343 ATP binding site [chemical binding]; other site 360102010344 Walker B motif; other site 360102010345 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 360102010346 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 360102010347 trimer interface [polypeptide binding]; other site 360102010348 putative metal binding site [ion binding]; other site 360102010349 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 360102010350 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 360102010351 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 360102010352 shikimate binding site; other site 360102010353 NAD(P) binding site [chemical binding]; other site 360102010354 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 360102010355 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360102010356 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 360102010357 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360102010358 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 360102010359 hypothetical protein; Validated; Region: PRK03430 360102010360 hypothetical protein; Provisional; Region: PRK10736 360102010361 DNA protecting protein DprA; Region: dprA; TIGR00732 360102010362 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 360102010363 active site 360102010364 catalytic residues [active] 360102010365 metal binding site [ion binding]; metal-binding site 360102010366 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 360102010367 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 360102010368 putative active site [active] 360102010369 substrate binding site [chemical binding]; other site 360102010370 putative cosubstrate binding site; other site 360102010371 catalytic site [active] 360102010372 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 360102010373 substrate binding site [chemical binding]; other site 360102010374 16S rRNA methyltransferase B; Provisional; Region: PRK10901 360102010375 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 360102010376 putative RNA binding site [nucleotide binding]; other site 360102010377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102010378 S-adenosylmethionine binding site [chemical binding]; other site 360102010379 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 360102010380 TrkA-N domain; Region: TrkA_N; pfam02254 360102010381 TrkA-C domain; Region: TrkA_C; pfam02080 360102010382 TrkA-N domain; Region: TrkA_N; pfam02254 360102010383 TrkA-C domain; Region: TrkA_C; pfam02080 360102010384 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 360102010385 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 360102010386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 360102010387 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 360102010388 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 360102010389 DNA binding residues [nucleotide binding] 360102010390 dimer interface [polypeptide binding]; other site 360102010391 metal binding site [ion binding]; metal-binding site 360102010392 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 360102010393 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 360102010394 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 360102010395 alphaNTD homodimer interface [polypeptide binding]; other site 360102010396 alphaNTD - beta interaction site [polypeptide binding]; other site 360102010397 alphaNTD - beta' interaction site [polypeptide binding]; other site 360102010398 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 360102010399 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 360102010400 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 360102010401 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360102010402 RNA binding surface [nucleotide binding]; other site 360102010403 30S ribosomal protein S11; Validated; Region: PRK05309 360102010404 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 360102010405 30S ribosomal protein S13; Region: bact_S13; TIGR03631 360102010406 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 360102010407 SecY translocase; Region: SecY; pfam00344 360102010408 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 360102010409 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 360102010410 23S rRNA binding site [nucleotide binding]; other site 360102010411 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 360102010412 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 360102010413 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 360102010414 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 360102010415 5S rRNA interface [nucleotide binding]; other site 360102010416 23S rRNA interface [nucleotide binding]; other site 360102010417 L5 interface [polypeptide binding]; other site 360102010418 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 360102010419 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 360102010420 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 360102010421 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 360102010422 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 360102010423 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 360102010424 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 360102010425 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 360102010426 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 360102010427 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 360102010428 RNA binding site [nucleotide binding]; other site 360102010429 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 360102010430 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 360102010431 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 360102010432 23S rRNA interface [nucleotide binding]; other site 360102010433 putative translocon interaction site; other site 360102010434 signal recognition particle (SRP54) interaction site; other site 360102010435 L23 interface [polypeptide binding]; other site 360102010436 trigger factor interaction site; other site 360102010437 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 360102010438 23S rRNA interface [nucleotide binding]; other site 360102010439 5S rRNA interface [nucleotide binding]; other site 360102010440 putative antibiotic binding site [chemical binding]; other site 360102010441 L25 interface [polypeptide binding]; other site 360102010442 L27 interface [polypeptide binding]; other site 360102010443 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 360102010444 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 360102010445 G-X-X-G motif; other site 360102010446 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 360102010447 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 360102010448 protein-rRNA interface [nucleotide binding]; other site 360102010449 putative translocon binding site; other site 360102010450 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 360102010451 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 360102010452 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 360102010453 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 360102010454 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 360102010455 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 360102010456 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 360102010457 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 360102010458 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 360102010459 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 360102010460 heme binding site [chemical binding]; other site 360102010461 ferroxidase pore; other site 360102010462 ferroxidase diiron center [ion binding]; other site 360102010463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102010464 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102010465 DNA-binding interface [nucleotide binding]; DNA binding site 360102010466 Integrase core domain; Region: rve; pfam00665 360102010467 transposase/IS protein; Provisional; Region: PRK09183 360102010468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102010469 Walker A motif; other site 360102010470 ATP binding site [chemical binding]; other site 360102010471 Walker B motif; other site 360102010472 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102010473 elongation factor Tu; Reviewed; Region: PRK00049 360102010474 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 360102010475 G1 box; other site 360102010476 GEF interaction site [polypeptide binding]; other site 360102010477 GTP/Mg2+ binding site [chemical binding]; other site 360102010478 Switch I region; other site 360102010479 G2 box; other site 360102010480 G3 box; other site 360102010481 Switch II region; other site 360102010482 G4 box; other site 360102010483 G5 box; other site 360102010484 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 360102010485 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 360102010486 Antibiotic Binding Site [chemical binding]; other site 360102010487 elongation factor G; Reviewed; Region: PRK00007 360102010488 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 360102010489 G1 box; other site 360102010490 putative GEF interaction site [polypeptide binding]; other site 360102010491 GTP/Mg2+ binding site [chemical binding]; other site 360102010492 Switch I region; other site 360102010493 G2 box; other site 360102010494 G3 box; other site 360102010495 Switch II region; other site 360102010496 G4 box; other site 360102010497 G5 box; other site 360102010498 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 360102010499 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 360102010500 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 360102010501 30S ribosomal protein S7; Validated; Region: PRK05302 360102010502 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 360102010503 S17 interaction site [polypeptide binding]; other site 360102010504 S8 interaction site; other site 360102010505 16S rRNA interaction site [nucleotide binding]; other site 360102010506 streptomycin interaction site [chemical binding]; other site 360102010507 23S rRNA interaction site [nucleotide binding]; other site 360102010508 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 360102010509 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 360102010510 sulfur relay protein TusC; Validated; Region: PRK00211 360102010511 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 360102010512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 360102010513 YheO-like PAS domain; Region: PAS_6; pfam08348 360102010514 HTH domain; Region: HTH_22; pfam13309 360102010515 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 360102010516 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 360102010517 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 360102010518 phi X174 lysis protein; Provisional; Region: PRK02793 360102010519 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 360102010520 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 360102010521 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 360102010522 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 360102010523 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 360102010524 TrkA-N domain; Region: TrkA_N; pfam02254 360102010525 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 360102010526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102010527 Walker A/P-loop; other site 360102010528 ATP binding site [chemical binding]; other site 360102010529 ABC transporter; Region: ABC_tran; pfam00005 360102010530 Q-loop/lid; other site 360102010531 ABC transporter signature motif; other site 360102010532 Walker B; other site 360102010533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102010534 H-loop/switch region; other site 360102010535 ABC transporter; Region: ABC_tran_2; pfam12848 360102010536 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360102010537 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360102010538 putative glycosyl transferase; Provisional; Region: PRK10073 360102010539 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 360102010540 active site 360102010541 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 360102010542 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360102010543 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360102010544 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 360102010545 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 360102010546 active site 360102010547 iron coordination sites [ion binding]; other site 360102010548 substrate binding pocket [chemical binding]; other site 360102010549 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 360102010550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102010551 dimer interface [polypeptide binding]; other site 360102010552 conserved gate region; other site 360102010553 putative PBP binding loops; other site 360102010554 ABC-ATPase subunit interface; other site 360102010555 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 360102010556 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 360102010557 Walker A/P-loop; other site 360102010558 ATP binding site [chemical binding]; other site 360102010559 Q-loop/lid; other site 360102010560 ABC transporter signature motif; other site 360102010561 Walker B; other site 360102010562 D-loop; other site 360102010563 H-loop/switch region; other site 360102010564 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 360102010565 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102010566 substrate binding pocket [chemical binding]; other site 360102010567 membrane-bound complex binding site; other site 360102010568 hinge residues; other site 360102010569 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 360102010570 putative hydrolase; Provisional; Region: PRK10985 360102010571 hypothetical protein; Provisional; Region: PRK04966 360102010572 phosphoribulokinase; Provisional; Region: PRK15453 360102010573 active site 360102010574 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 360102010575 hypothetical protein; Provisional; Region: PRK10738 360102010576 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 360102010577 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 360102010578 ligand binding site [chemical binding]; other site 360102010579 flexible hinge region; other site 360102010580 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 360102010581 putative switch regulator; other site 360102010582 non-specific DNA interactions [nucleotide binding]; other site 360102010583 DNA binding site [nucleotide binding] 360102010584 sequence specific DNA binding site [nucleotide binding]; other site 360102010585 putative cAMP binding site [chemical binding]; other site 360102010586 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 360102010587 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 360102010588 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 360102010589 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 360102010590 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 360102010591 inhibitor-cofactor binding pocket; inhibition site 360102010592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102010593 catalytic residue [active] 360102010594 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 360102010595 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 360102010596 glutamine binding [chemical binding]; other site 360102010597 catalytic triad [active] 360102010598 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 360102010599 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 360102010600 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 360102010601 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 360102010602 substrate binding site [chemical binding]; other site 360102010603 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 360102010604 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 360102010605 NAD binding site [chemical binding]; other site 360102010606 sugar binding site [chemical binding]; other site 360102010607 divalent metal binding site [ion binding]; other site 360102010608 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360102010609 dimer interface [polypeptide binding]; other site 360102010610 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360102010611 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102010612 DNA binding site [nucleotide binding] 360102010613 domain linker motif; other site 360102010614 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 360102010615 dimerization interface (closed form) [polypeptide binding]; other site 360102010616 ligand binding site [chemical binding]; other site 360102010617 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 360102010618 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 360102010619 N-terminal plug; other site 360102010620 ligand-binding site [chemical binding]; other site 360102010621 putative transporter; Provisional; Region: PRK03699 360102010622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102010623 putative substrate translocation pore; other site 360102010624 cytosine deaminase; Provisional; Region: PRK09230 360102010625 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 360102010626 active site 360102010627 nitrite reductase subunit NirD; Provisional; Region: PRK14989 360102010628 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360102010629 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 360102010630 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 360102010631 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 360102010632 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 360102010633 nitrite transporter NirC; Provisional; Region: PRK11562 360102010634 siroheme synthase; Provisional; Region: cysG; PRK10637 360102010635 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 360102010636 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 360102010637 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 360102010638 active site 360102010639 SAM binding site [chemical binding]; other site 360102010640 homodimer interface [polypeptide binding]; other site 360102010641 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 360102010642 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 360102010643 active site 360102010644 HIGH motif; other site 360102010645 dimer interface [polypeptide binding]; other site 360102010646 KMSKS motif; other site 360102010647 phosphoglycolate phosphatase; Provisional; Region: PRK13222 360102010648 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 360102010649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102010650 motif II; other site 360102010651 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 360102010652 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 360102010653 substrate binding site [chemical binding]; other site 360102010654 hexamer interface [polypeptide binding]; other site 360102010655 metal binding site [ion binding]; metal-binding site 360102010656 DNA adenine methylase; Provisional; Region: PRK10904 360102010657 hypothetical protein; Reviewed; Region: PRK11901 360102010658 cell division protein DamX; Validated; Region: PRK10905 360102010659 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 360102010660 active site 360102010661 dimer interface [polypeptide binding]; other site 360102010662 metal binding site [ion binding]; metal-binding site 360102010663 shikimate kinase; Reviewed; Region: aroK; PRK00131 360102010664 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 360102010665 ADP binding site [chemical binding]; other site 360102010666 magnesium binding site [ion binding]; other site 360102010667 putative shikimate binding site; other site 360102010668 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 360102010669 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 360102010670 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 360102010671 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 360102010672 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 360102010673 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 360102010674 Competence protein A; Region: Competence_A; pfam11104 360102010675 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 360102010676 Transglycosylase; Region: Transgly; pfam00912 360102010677 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 360102010678 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 360102010679 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 360102010680 ADP-ribose binding site [chemical binding]; other site 360102010681 dimer interface [polypeptide binding]; other site 360102010682 active site 360102010683 nudix motif; other site 360102010684 metal binding site [ion binding]; metal-binding site 360102010685 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 360102010686 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 360102010687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 360102010688 motif I; other site 360102010689 active site 360102010690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102010691 motif II; other site 360102010692 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 360102010693 RNA binding surface [nucleotide binding]; other site 360102010694 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 360102010695 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 360102010696 dimerization interface [polypeptide binding]; other site 360102010697 domain crossover interface; other site 360102010698 redox-dependent activation switch; other site 360102010699 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 360102010700 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 360102010701 active site 360102010702 substrate-binding site [chemical binding]; other site 360102010703 metal-binding site [ion binding] 360102010704 ATP binding site [chemical binding]; other site 360102010705 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 360102010706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102010707 dimerization interface [polypeptide binding]; other site 360102010708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102010709 dimer interface [polypeptide binding]; other site 360102010710 phosphorylation site [posttranslational modification] 360102010711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102010712 ATP binding site [chemical binding]; other site 360102010713 Mg2+ binding site [ion binding]; other site 360102010714 G-X-G motif; other site 360102010715 osmolarity response regulator; Provisional; Region: ompR; PRK09468 360102010716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102010717 active site 360102010718 phosphorylation site [posttranslational modification] 360102010719 intermolecular recognition site; other site 360102010720 dimerization interface [polypeptide binding]; other site 360102010721 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102010722 DNA binding site [nucleotide binding] 360102010723 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 360102010724 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 360102010725 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 360102010726 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 360102010727 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 360102010728 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 360102010729 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 360102010730 RNA binding site [nucleotide binding]; other site 360102010731 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 360102010732 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 360102010733 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 360102010734 G1 box; other site 360102010735 GTP/Mg2+ binding site [chemical binding]; other site 360102010736 Switch I region; other site 360102010737 G2 box; other site 360102010738 G3 box; other site 360102010739 Switch II region; other site 360102010740 G4 box; other site 360102010741 G5 box; other site 360102010742 Nucleoside recognition; Region: Gate; pfam07670 360102010743 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 360102010744 Nucleoside recognition; Region: Gate; pfam07670 360102010745 FeoC like transcriptional regulator; Region: FeoC; cl17677 360102010746 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 360102010747 carboxylesterase BioH; Provisional; Region: PRK10349 360102010748 DNA utilization protein GntX; Provisional; Region: PRK11595 360102010749 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360102010750 active site 360102010751 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 360102010752 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 360102010753 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 360102010754 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 360102010755 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 360102010756 maltodextrin phosphorylase; Provisional; Region: PRK14985 360102010757 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 360102010758 active site pocket [active] 360102010759 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360102010760 transcriptional regulator MalT; Provisional; Region: PRK04841 360102010761 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102010762 DNA binding residues [nucleotide binding] 360102010763 dimerization interface [polypeptide binding]; other site 360102010764 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 360102010765 active site residue [active] 360102010766 intramembrane serine protease GlpG; Provisional; Region: PRK10907 360102010767 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 360102010768 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 360102010769 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 360102010770 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 360102010771 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 360102010772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 360102010773 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102010774 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102010775 transposase/IS protein; Provisional; Region: PRK09183 360102010776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102010777 Walker A motif; other site 360102010778 ATP binding site [chemical binding]; other site 360102010779 Walker B motif; other site 360102010780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102010781 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102010782 DNA-binding interface [nucleotide binding]; DNA binding site 360102010783 Integrase core domain; Region: rve; pfam00665 360102010784 putative transposase OrfB; Reviewed; Region: PHA02517 360102010785 HTH-like domain; Region: HTH_21; pfam13276 360102010786 Integrase core domain; Region: rve; pfam00665 360102010787 Integrase core domain; Region: rve_2; pfam13333 360102010788 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 360102010789 PAS domain S-box; Region: sensory_box; TIGR00229 360102010790 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360102010791 putative active site [active] 360102010792 heme pocket [chemical binding]; other site 360102010793 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360102010794 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360102010795 metal binding site [ion binding]; metal-binding site 360102010796 active site 360102010797 I-site; other site 360102010798 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360102010799 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 360102010800 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102010801 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102010802 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 360102010803 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 360102010804 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 360102010805 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 360102010806 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 360102010807 Autotransporter beta-domain; Region: Autotransporter; pfam03797 360102010808 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 360102010809 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 360102010810 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 360102010811 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102010812 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 360102010813 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 360102010814 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 360102010815 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 360102010816 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 360102010817 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 360102010818 metal binding site [ion binding]; metal-binding site 360102010819 dimer interface [polypeptide binding]; other site 360102010820 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 360102010821 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 360102010822 N-terminal plug; other site 360102010823 ligand-binding site [chemical binding]; other site 360102010824 acyl-CoA synthetase; Validated; Region: PRK05850 360102010825 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 360102010826 acyl-activating enzyme (AAE) consensus motif; other site 360102010827 active site 360102010828 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 360102010829 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 360102010830 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 360102010831 active site 360102010832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102010833 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102010834 DNA-binding interface [nucleotide binding]; DNA binding site 360102010835 Integrase core domain; Region: rve; pfam00665 360102010836 transposase/IS protein; Provisional; Region: PRK09183 360102010837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102010838 Walker A motif; other site 360102010839 ATP binding site [chemical binding]; other site 360102010840 Walker B motif; other site 360102010841 Condensation domain; Region: Condensation; pfam00668 360102010842 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 360102010843 Nonribosomal peptide synthase; Region: NRPS; pfam08415 360102010844 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 360102010845 acyl-activating enzyme (AAE) consensus motif; other site 360102010846 AMP binding site [chemical binding]; other site 360102010847 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 360102010848 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 360102010849 Condensation domain; Region: Condensation; pfam00668 360102010850 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 360102010851 Nonribosomal peptide synthase; Region: NRPS; pfam08415 360102010852 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 360102010853 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 360102010854 acyl-activating enzyme (AAE) consensus motif; other site 360102010855 AMP binding site [chemical binding]; other site 360102010856 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 360102010857 Condensation domain; Region: Condensation; pfam00668 360102010858 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 360102010859 Nonribosomal peptide synthase; Region: NRPS; pfam08415 360102010860 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 360102010861 acyl-activating enzyme (AAE) consensus motif; other site 360102010862 AMP binding site [chemical binding]; other site 360102010863 Methyltransferase domain; Region: Methyltransf_31; pfam13847 360102010864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102010865 S-adenosylmethionine binding site [chemical binding]; other site 360102010866 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 360102010867 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 360102010868 Thioesterase domain; Region: Thioesterase; pfam00975 360102010869 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 360102010870 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 360102010871 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360102010872 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 360102010873 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 360102010874 muropeptide transporter; Validated; Region: ampG; cl17669 360102010875 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360102010876 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360102010877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102010878 Walker A/P-loop; other site 360102010879 ATP binding site [chemical binding]; other site 360102010880 Q-loop/lid; other site 360102010881 ABC transporter signature motif; other site 360102010882 Walker B; other site 360102010883 D-loop; other site 360102010884 H-loop/switch region; other site 360102010885 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 360102010886 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360102010887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102010888 Walker A/P-loop; other site 360102010889 ATP binding site [chemical binding]; other site 360102010890 Q-loop/lid; other site 360102010891 ABC transporter signature motif; other site 360102010892 Walker B; other site 360102010893 D-loop; other site 360102010894 H-loop/switch region; other site 360102010895 fructuronate transporter; Provisional; Region: PRK10034 360102010896 gluconate transporter; Region: gntP; TIGR00791 360102010897 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 360102010898 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 360102010899 Autotransporter beta-domain; Region: Autotransporter; smart00869 360102010900 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 360102010901 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 360102010902 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 360102010903 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 360102010904 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 360102010905 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 360102010906 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 360102010907 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 360102010908 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 360102010909 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 360102010910 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 360102010911 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 360102010912 RHS Repeat; Region: RHS_repeat; pfam05593 360102010913 RHS Repeat; Region: RHS_repeat; cl11982 360102010914 RHS protein; Region: RHS; pfam03527 360102010915 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 360102010916 hypothetical protein; Provisional; Region: PRK10039 360102010917 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 360102010918 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 360102010919 transmembrane helices; other site 360102010920 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360102010921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102010922 DNA binding site [nucleotide binding] 360102010923 domain linker motif; other site 360102010924 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 360102010925 putative dimerization interface [polypeptide binding]; other site 360102010926 putative ligand binding site [chemical binding]; other site 360102010927 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 360102010928 putative transposase OrfB; Reviewed; Region: PHA02517 360102010929 HTH-like domain; Region: HTH_21; pfam13276 360102010930 Integrase core domain; Region: rve; pfam00665 360102010931 Integrase core domain; Region: rve_2; pfam13333 360102010932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 360102010933 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102010934 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102010935 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 360102010936 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 360102010937 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 360102010938 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 360102010939 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 360102010940 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 360102010941 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 360102010942 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 360102010943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102010944 Walker A motif; other site 360102010945 ATP binding site [chemical binding]; other site 360102010946 Walker B motif; other site 360102010947 arginine finger; other site 360102010948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102010949 Walker A motif; other site 360102010950 ATP binding site [chemical binding]; other site 360102010951 Walker B motif; other site 360102010952 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 360102010953 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 360102010954 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 360102010955 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 360102010956 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 360102010957 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 360102010958 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 360102010959 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 360102010960 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 360102010961 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 360102010962 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 360102010963 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 360102010964 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 360102010965 ImpA domain protein; Region: DUF3702; pfam12486 360102010966 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 360102010967 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 360102010968 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 360102010969 Uncharacterized conserved protein [Function unknown]; Region: COG5435 360102010970 PAAR motif; Region: PAAR_motif; pfam05488 360102010971 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 360102010972 RHS Repeat; Region: RHS_repeat; pfam05593 360102010973 RHS Repeat; Region: RHS_repeat; pfam05593 360102010974 RHS Repeat; Region: RHS_repeat; cl11982 360102010975 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 360102010976 RHS protein; Region: RHS; pfam03527 360102010977 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 360102010978 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 360102010979 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 360102010980 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 360102010981 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 360102010982 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 360102010983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360102010984 non-specific DNA binding site [nucleotide binding]; other site 360102010985 salt bridge; other site 360102010986 sequence-specific DNA binding site [nucleotide binding]; other site 360102010987 ImpA domain protein; Region: DUF3702; pfam12486 360102010988 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 360102010989 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 360102010990 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 360102010991 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 360102010992 Uncharacterized conserved protein [Function unknown]; Region: COG5435 360102010993 PAAR motif; Region: PAAR_motif; pfam05488 360102010994 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 360102010995 RHS Repeat; Region: RHS_repeat; pfam05593 360102010996 RHS Repeat; Region: RHS_repeat; pfam05593 360102010997 RHS Repeat; Region: RHS_repeat; pfam05593 360102010998 RHS Repeat; Region: RHS_repeat; pfam05593 360102010999 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 360102011000 RHS protein; Region: RHS; pfam03527 360102011001 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 360102011002 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 360102011003 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 360102011004 AP (apurinic/apyrimidinic) site pocket; other site 360102011005 DNA interaction; other site 360102011006 Metal-binding active site; metal-binding site 360102011007 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360102011008 transposase/IS protein; Provisional; Region: PRK09183 360102011009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102011010 Walker A motif; other site 360102011011 ATP binding site [chemical binding]; other site 360102011012 Walker B motif; other site 360102011013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102011014 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102011015 DNA-binding interface [nucleotide binding]; DNA binding site 360102011016 Integrase core domain; Region: rve; pfam00665 360102011017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360102011018 Coenzyme A binding pocket [chemical binding]; other site 360102011019 pantothenate kinase; Provisional; Region: PRK05439 360102011020 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 360102011021 ATP-binding site [chemical binding]; other site 360102011022 CoA-binding site [chemical binding]; other site 360102011023 Mg2+-binding site [ion binding]; other site 360102011024 Biotin operon repressor [Transcription]; Region: BirA; COG1654 360102011025 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 360102011026 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 360102011027 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 360102011028 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 360102011029 FAD binding domain; Region: FAD_binding_4; pfam01565 360102011030 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 360102011031 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 360102011032 potassium transporter; Provisional; Region: PRK10750 360102011033 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 360102011034 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 360102011035 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 360102011036 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102011037 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 360102011038 proline dipeptidase; Provisional; Region: PRK13607 360102011039 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 360102011040 active site 360102011041 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 360102011042 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 360102011043 substrate binding site [chemical binding]; other site 360102011044 oxyanion hole (OAH) forming residues; other site 360102011045 trimer interface [polypeptide binding]; other site 360102011046 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 360102011047 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 360102011048 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 360102011049 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 360102011050 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 360102011051 dimer interface [polypeptide binding]; other site 360102011052 active site 360102011053 FMN reductase; Validated; Region: fre; PRK08051 360102011054 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 360102011055 FAD binding pocket [chemical binding]; other site 360102011056 FAD binding motif [chemical binding]; other site 360102011057 phosphate binding motif [ion binding]; other site 360102011058 beta-alpha-beta structure motif; other site 360102011059 NAD binding pocket [chemical binding]; other site 360102011060 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 360102011061 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 360102011062 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 360102011063 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 360102011064 heterodimer interface [polypeptide binding]; other site 360102011065 homodimer interface [polypeptide binding]; other site 360102011066 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 360102011067 dimer interface [polypeptide binding]; other site 360102011068 allosteric magnesium binding site [ion binding]; other site 360102011069 active site 360102011070 aspartate-rich active site metal binding site; other site 360102011071 Schiff base residues; other site 360102011072 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 360102011073 transposase/IS protein; Provisional; Region: PRK09183 360102011074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102011075 Walker A motif; other site 360102011076 ATP binding site [chemical binding]; other site 360102011077 Walker B motif; other site 360102011078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102011079 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102011080 DNA-binding interface [nucleotide binding]; DNA binding site 360102011081 Integrase core domain; Region: rve; pfam00665 360102011082 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 360102011083 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102011084 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102011085 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 360102011086 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 360102011087 putative active site [active] 360102011088 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 360102011089 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 360102011090 Walker A/P-loop; other site 360102011091 ATP binding site [chemical binding]; other site 360102011092 Q-loop/lid; other site 360102011093 ABC transporter signature motif; other site 360102011094 Walker B; other site 360102011095 D-loop; other site 360102011096 H-loop/switch region; other site 360102011097 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102011098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 360102011099 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 360102011100 amphipathic channel; other site 360102011101 Asn-Pro-Ala signature motifs; other site 360102011102 glycerol kinase; Provisional; Region: glpK; PRK00047 360102011103 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 360102011104 N- and C-terminal domain interface [polypeptide binding]; other site 360102011105 active site 360102011106 MgATP binding site [chemical binding]; other site 360102011107 catalytic site [active] 360102011108 metal binding site [ion binding]; metal-binding site 360102011109 glycerol binding site [chemical binding]; other site 360102011110 homotetramer interface [polypeptide binding]; other site 360102011111 homodimer interface [polypeptide binding]; other site 360102011112 FBP binding site [chemical binding]; other site 360102011113 protein IIAGlc interface [polypeptide binding]; other site 360102011114 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 360102011115 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 360102011116 putative active site [active] 360102011117 ferredoxin-NADP reductase; Provisional; Region: PRK10926 360102011118 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 360102011119 FAD binding pocket [chemical binding]; other site 360102011120 FAD binding motif [chemical binding]; other site 360102011121 phosphate binding motif [ion binding]; other site 360102011122 beta-alpha-beta structure motif; other site 360102011123 NAD binding pocket [chemical binding]; other site 360102011124 Predicted membrane protein [Function unknown]; Region: COG3152 360102011125 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 360102011126 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 360102011127 triosephosphate isomerase; Provisional; Region: PRK14567 360102011128 substrate binding site [chemical binding]; other site 360102011129 dimer interface [polypeptide binding]; other site 360102011130 catalytic triad [active] 360102011131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102011132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102011133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102011134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102011135 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360102011136 dimerization interface [polypeptide binding]; other site 360102011137 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 360102011138 hypothetical protein; Validated; Region: PRK06201 360102011139 hypothetical protein; Provisional; Region: PRK09262 360102011140 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 360102011141 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 360102011142 transmembrane helices; other site 360102011143 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 360102011144 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 360102011145 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102011146 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 360102011147 substrate binding pocket [chemical binding]; other site 360102011148 membrane-bound complex binding site; other site 360102011149 hinge residues; other site 360102011150 6-phosphofructokinase; Provisional; Region: PRK03202 360102011151 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 360102011152 active site 360102011153 ADP/pyrophosphate binding site [chemical binding]; other site 360102011154 dimerization interface [polypeptide binding]; other site 360102011155 allosteric effector site; other site 360102011156 fructose-1,6-bisphosphate binding site; other site 360102011157 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 360102011158 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 360102011159 Uncharacterized conserved protein [Function unknown]; Region: COG5464 360102011160 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 360102011161 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 360102011162 active site 360102011163 Int/Topo IB signature motif; other site 360102011164 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 360102011165 dimer interface [polypeptide binding]; other site 360102011166 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 360102011167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102011168 active site 360102011169 phosphorylation site [posttranslational modification] 360102011170 intermolecular recognition site; other site 360102011171 dimerization interface [polypeptide binding]; other site 360102011172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102011173 DNA binding site [nucleotide binding] 360102011174 two-component sensor protein; Provisional; Region: cpxA; PRK09470 360102011175 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 360102011176 dimerization interface [polypeptide binding]; other site 360102011177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102011178 dimer interface [polypeptide binding]; other site 360102011179 phosphorylation site [posttranslational modification] 360102011180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102011181 ATP binding site [chemical binding]; other site 360102011182 Mg2+ binding site [ion binding]; other site 360102011183 G-X-G motif; other site 360102011184 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 360102011185 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 360102011186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102011187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102011188 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 360102011189 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 360102011190 DNA binding site [nucleotide binding] 360102011191 active site 360102011192 putative rRNA methylase; Provisional; Region: PRK10358 360102011193 serine acetyltransferase; Provisional; Region: cysE; PRK11132 360102011194 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 360102011195 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 360102011196 trimer interface [polypeptide binding]; other site 360102011197 active site 360102011198 substrate binding site [chemical binding]; other site 360102011199 CoA binding site [chemical binding]; other site 360102011200 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 360102011201 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 360102011202 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 360102011203 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 360102011204 SecA binding site; other site 360102011205 Preprotein binding site; other site 360102011206 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 360102011207 GSH binding site [chemical binding]; other site 360102011208 catalytic residues [active] 360102011209 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 360102011210 active site residue [active] 360102011211 phosphoglyceromutase; Provisional; Region: PRK05434 360102011212 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 360102011213 AmiB activator; Provisional; Region: PRK11637 360102011214 Peptidase family M23; Region: Peptidase_M23; pfam01551 360102011215 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 360102011216 NodB motif; other site 360102011217 putative active site [active] 360102011218 Zn binding site [ion binding]; other site 360102011219 Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl17042 360102011220 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 360102011221 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 360102011222 NAD(P) binding site [chemical binding]; other site 360102011223 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 360102011224 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 360102011225 substrate-cofactor binding pocket; other site 360102011226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102011227 catalytic residue [active] 360102011228 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 360102011229 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 360102011230 NADP binding site [chemical binding]; other site 360102011231 homopentamer interface [polypeptide binding]; other site 360102011232 substrate binding site [chemical binding]; other site 360102011233 active site 360102011234 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 360102011235 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 360102011236 putative active site [active] 360102011237 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 360102011238 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 360102011239 putative active site [active] 360102011240 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 360102011241 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 360102011242 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 360102011243 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 360102011244 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 360102011245 putative metal binding site; other site 360102011246 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 360102011247 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 360102011248 active site 360102011249 (T/H)XGH motif; other site 360102011250 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 360102011251 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 360102011252 DNA binding site [nucleotide binding] 360102011253 catalytic residue [active] 360102011254 H2TH interface [polypeptide binding]; other site 360102011255 putative catalytic residues [active] 360102011256 turnover-facilitating residue; other site 360102011257 intercalation triad [nucleotide binding]; other site 360102011258 8OG recognition residue [nucleotide binding]; other site 360102011259 putative reading head residues; other site 360102011260 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 360102011261 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 360102011262 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 360102011263 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 360102011264 hypothetical protein; Reviewed; Region: PRK00024 360102011265 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 360102011266 MPN+ (JAMM) motif; other site 360102011267 Zinc-binding site [ion binding]; other site 360102011268 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 360102011269 Flavoprotein; Region: Flavoprotein; pfam02441 360102011270 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 360102011271 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 360102011272 trimer interface [polypeptide binding]; other site 360102011273 active site 360102011274 division inhibitor protein; Provisional; Region: slmA; PRK09480 360102011275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360102011276 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360102011277 active site 360102011278 ribonuclease PH; Reviewed; Region: rph; PRK00173 360102011279 Ribonuclease PH; Region: RNase_PH_bact; cd11362 360102011280 hexamer interface [polypeptide binding]; other site 360102011281 active site 360102011282 hypothetical protein; Provisional; Region: PRK11820 360102011283 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 360102011284 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 360102011285 Predicted membrane protein [Function unknown]; Region: COG2860 360102011286 UPF0126 domain; Region: UPF0126; pfam03458 360102011287 UPF0126 domain; Region: UPF0126; pfam03458 360102011288 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 360102011289 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 360102011290 nucleotide binding pocket [chemical binding]; other site 360102011291 K-X-D-G motif; other site 360102011292 catalytic site [active] 360102011293 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 360102011294 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 360102011295 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 360102011296 catalytic site [active] 360102011297 G-X2-G-X-G-K; other site 360102011298 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 360102011299 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 360102011300 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 360102011301 Zn2+ binding site [ion binding]; other site 360102011302 Mg2+ binding site [ion binding]; other site 360102011303 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 360102011304 synthetase active site [active] 360102011305 NTP binding site [chemical binding]; other site 360102011306 metal binding site [ion binding]; metal-binding site 360102011307 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 360102011308 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 360102011309 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 360102011310 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 360102011311 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 360102011312 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 360102011313 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 360102011314 generic binding surface II; other site 360102011315 ssDNA binding site; other site 360102011316 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360102011317 ATP binding site [chemical binding]; other site 360102011318 putative Mg++ binding site [ion binding]; other site 360102011319 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102011320 nucleotide binding region [chemical binding]; other site 360102011321 ATP-binding site [chemical binding]; other site 360102011322 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 360102011323 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 360102011324 AsmA family; Region: AsmA; pfam05170 360102011325 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 360102011326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360102011327 Coenzyme A binding pocket [chemical binding]; other site 360102011328 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 360102011329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102011330 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102011331 DNA-binding interface [nucleotide binding]; DNA binding site 360102011332 Integrase core domain; Region: rve; pfam00665 360102011333 transposase/IS protein; Provisional; Region: PRK09183 360102011334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102011335 Walker A motif; other site 360102011336 ATP binding site [chemical binding]; other site 360102011337 Walker B motif; other site 360102011338 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 360102011339 putative active site [active] 360102011340 dimerization interface [polypeptide binding]; other site 360102011341 putative tRNAtyr binding site [nucleotide binding]; other site 360102011342 hypothetical protein; Reviewed; Region: PRK01637 360102011343 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 360102011344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102011345 motif II; other site 360102011346 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 360102011347 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 360102011348 G1 box; other site 360102011349 putative GEF interaction site [polypeptide binding]; other site 360102011350 GTP/Mg2+ binding site [chemical binding]; other site 360102011351 Switch I region; other site 360102011352 G2 box; other site 360102011353 G3 box; other site 360102011354 Switch II region; other site 360102011355 G4 box; other site 360102011356 G5 box; other site 360102011357 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 360102011358 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 360102011359 glutamine synthetase; Provisional; Region: glnA; PRK09469 360102011360 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 360102011361 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 360102011362 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102011363 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 360102011364 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 360102011365 dimer interface [polypeptide binding]; other site 360102011366 phosphorylation site [posttranslational modification] 360102011367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102011368 ATP binding site [chemical binding]; other site 360102011369 Mg2+ binding site [ion binding]; other site 360102011370 G-X-G motif; other site 360102011371 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 360102011372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102011373 active site 360102011374 phosphorylation site [posttranslational modification] 360102011375 intermolecular recognition site; other site 360102011376 dimerization interface [polypeptide binding]; other site 360102011377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102011378 Walker A motif; other site 360102011379 ATP binding site [chemical binding]; other site 360102011380 Walker B motif; other site 360102011381 arginine finger; other site 360102011382 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 360102011383 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 360102011384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102011385 FeS/SAM binding site; other site 360102011386 HemN C-terminal domain; Region: HemN_C; pfam06969 360102011387 Der GTPase activator; Provisional; Region: PRK05244 360102011388 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 360102011389 G1 box; other site 360102011390 GTP/Mg2+ binding site [chemical binding]; other site 360102011391 Switch I region; other site 360102011392 G2 box; other site 360102011393 G3 box; other site 360102011394 Switch II region; other site 360102011395 G4 box; other site 360102011396 G5 box; other site 360102011397 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102011398 DNA polymerase I; Provisional; Region: PRK05755 360102011399 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 360102011400 active site 360102011401 metal binding site 1 [ion binding]; metal-binding site 360102011402 putative 5' ssDNA interaction site; other site 360102011403 metal binding site 3; metal-binding site 360102011404 metal binding site 2 [ion binding]; metal-binding site 360102011405 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 360102011406 putative DNA binding site [nucleotide binding]; other site 360102011407 putative metal binding site [ion binding]; other site 360102011408 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 360102011409 active site 360102011410 catalytic site [active] 360102011411 substrate binding site [chemical binding]; other site 360102011412 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 360102011413 active site 360102011414 DNA binding site [nucleotide binding] 360102011415 catalytic site [active] 360102011416 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 360102011417 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 360102011418 catalytic residues [active] 360102011419 hinge region; other site 360102011420 alpha helical domain; other site 360102011421 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 360102011422 serine/threonine protein kinase; Provisional; Region: PRK11768 360102011423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3084 360102011424 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 360102011425 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 360102011426 GTP binding site; other site 360102011427 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 360102011428 Walker A motif; other site 360102011429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 360102011430 MULE transposase domain; Region: MULE; pfam10551 360102011431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102011432 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102011433 DNA-binding interface [nucleotide binding]; DNA binding site 360102011434 Integrase core domain; Region: rve; pfam00665 360102011435 transposase/IS protein; Provisional; Region: PRK09183 360102011436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102011437 Walker A motif; other site 360102011438 ATP binding site [chemical binding]; other site 360102011439 Walker B motif; other site 360102011440 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 360102011441 active site 360102011442 8-oxo-dGMP binding site [chemical binding]; other site 360102011443 nudix motif; other site 360102011444 metal binding site [ion binding]; metal-binding site 360102011445 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 360102011446 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 360102011447 SEC-C motif; Region: SEC-C; pfam02810 360102011448 SecA regulator SecM; Provisional; Region: PRK02943 360102011449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 360102011450 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 360102011451 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 360102011452 cell division protein FtsZ; Validated; Region: PRK09330 360102011453 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 360102011454 nucleotide binding site [chemical binding]; other site 360102011455 SulA interaction site; other site 360102011456 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 360102011457 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 360102011458 Cell division protein FtsA; Region: FtsA; pfam14450 360102011459 cell division protein FtsQ; Provisional; Region: PRK10775 360102011460 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 360102011461 Cell division protein FtsQ; Region: FtsQ; pfam03799 360102011462 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 360102011463 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 360102011464 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 360102011465 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 360102011466 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360102011467 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360102011468 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360102011469 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 360102011470 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 360102011471 active site 360102011472 homodimer interface [polypeptide binding]; other site 360102011473 cell division protein FtsW; Provisional; Region: PRK10774 360102011474 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 360102011475 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 360102011476 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360102011477 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360102011478 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 360102011479 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 360102011480 Mg++ binding site [ion binding]; other site 360102011481 putative catalytic motif [active] 360102011482 putative substrate binding site [chemical binding]; other site 360102011483 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 360102011484 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360102011485 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360102011486 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360102011487 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 360102011488 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 360102011489 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 360102011490 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 360102011491 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 360102011492 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 360102011493 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 360102011494 cell division protein FtsL; Provisional; Region: PRK10772 360102011495 MraW methylase family; Region: Methyltransf_5; pfam01795 360102011496 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 360102011497 cell division protein MraZ; Reviewed; Region: PRK00326 360102011498 MraZ protein; Region: MraZ; pfam02381 360102011499 MraZ protein; Region: MraZ; pfam02381 360102011500 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 360102011501 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 360102011502 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102011503 DNA binding site [nucleotide binding] 360102011504 domain linker motif; other site 360102011505 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 360102011506 dimerization interface [polypeptide binding]; other site 360102011507 ligand binding site [chemical binding]; other site 360102011508 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102011509 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 360102011510 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 360102011511 putative valine binding site [chemical binding]; other site 360102011512 dimer interface [polypeptide binding]; other site 360102011513 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 360102011514 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 360102011515 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 360102011516 PYR/PP interface [polypeptide binding]; other site 360102011517 dimer interface [polypeptide binding]; other site 360102011518 TPP binding site [chemical binding]; other site 360102011519 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 360102011520 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 360102011521 TPP-binding site [chemical binding]; other site 360102011522 dimer interface [polypeptide binding]; other site 360102011523 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 360102011524 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 360102011525 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 360102011526 acyl-activating enzyme (AAE) consensus motif; other site 360102011527 acyl-activating enzyme (AAE) consensus motif; other site 360102011528 putative AMP binding site [chemical binding]; other site 360102011529 putative active site [active] 360102011530 putative CoA binding site [chemical binding]; other site 360102011531 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 360102011532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102011533 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 360102011534 putative substrate binding pocket [chemical binding]; other site 360102011535 putative dimerization interface [polypeptide binding]; other site 360102011536 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102011537 2-isopropylmalate synthase; Validated; Region: PRK00915 360102011538 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 360102011539 active site 360102011540 catalytic residues [active] 360102011541 metal binding site [ion binding]; metal-binding site 360102011542 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 360102011543 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 360102011544 tartrate dehydrogenase; Region: TTC; TIGR02089 360102011545 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 360102011546 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 360102011547 substrate binding site [chemical binding]; other site 360102011548 ligand binding site [chemical binding]; other site 360102011549 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 360102011550 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 360102011551 substrate binding site [chemical binding]; other site 360102011552 sugar efflux transporter; Region: 2A0120; TIGR00899 360102011553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102011554 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102011555 DNA-binding interface [nucleotide binding]; DNA binding site 360102011556 Integrase core domain; Region: rve; pfam00665 360102011557 transposase/IS protein; Provisional; Region: PRK09183 360102011558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102011559 Walker A motif; other site 360102011560 ATP binding site [chemical binding]; other site 360102011561 Walker B motif; other site 360102011562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102011563 putative substrate translocation pore; other site 360102011564 transcriptional regulator SgrR; Provisional; Region: PRK13626 360102011565 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 360102011566 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 360102011567 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 360102011568 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 360102011569 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 360102011570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102011571 dimer interface [polypeptide binding]; other site 360102011572 conserved gate region; other site 360102011573 putative PBP binding loops; other site 360102011574 ABC-ATPase subunit interface; other site 360102011575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102011576 dimer interface [polypeptide binding]; other site 360102011577 conserved gate region; other site 360102011578 putative PBP binding loops; other site 360102011579 ABC-ATPase subunit interface; other site 360102011580 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 360102011581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102011582 Walker A/P-loop; other site 360102011583 ATP binding site [chemical binding]; other site 360102011584 Q-loop/lid; other site 360102011585 ABC transporter signature motif; other site 360102011586 Walker B; other site 360102011587 D-loop; other site 360102011588 H-loop/switch region; other site 360102011589 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 360102011590 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 360102011591 DNA polymerase II; Reviewed; Region: PRK05762 360102011592 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 360102011593 active site 360102011594 catalytic site [active] 360102011595 substrate binding site [chemical binding]; other site 360102011596 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 360102011597 active site 360102011598 metal-binding site 360102011599 ATP-dependent helicase HepA; Validated; Region: PRK04914 360102011600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 360102011601 ATP binding site [chemical binding]; other site 360102011602 putative Mg++ binding site [ion binding]; other site 360102011603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 360102011604 nucleotide binding region [chemical binding]; other site 360102011605 ATP-binding site [chemical binding]; other site 360102011606 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 360102011607 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 360102011608 G1 box; other site 360102011609 GTP/Mg2+ binding site [chemical binding]; other site 360102011610 G2 box; other site 360102011611 G3 box; other site 360102011612 Switch II region; other site 360102011613 G4 box; other site 360102011614 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 360102011615 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 360102011616 hypothetical protein; Provisional; Region: PRK07034 360102011617 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 360102011618 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360102011619 ligand binding site [chemical binding]; other site 360102011620 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 360102011621 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 360102011622 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 360102011623 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 360102011624 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 360102011625 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 360102011626 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 360102011627 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 360102011628 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 360102011629 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 360102011630 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 360102011631 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 360102011632 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 360102011633 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 360102011634 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 360102011635 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 360102011636 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 360102011637 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 360102011638 Clp amino terminal domain; Region: Clp_N; pfam02861 360102011639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102011640 Walker A motif; other site 360102011641 ATP binding site [chemical binding]; other site 360102011642 Walker B motif; other site 360102011643 arginine finger; other site 360102011644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102011645 Walker A motif; other site 360102011646 ATP binding site [chemical binding]; other site 360102011647 Walker B motif; other site 360102011648 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 360102011649 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 360102011650 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 360102011651 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 360102011652 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 360102011653 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 360102011654 Protein of unknown function (DUF877); Region: DUF877; pfam05943 360102011655 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 360102011656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102011657 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102011658 DNA-binding interface [nucleotide binding]; DNA binding site 360102011659 Integrase core domain; Region: rve; pfam00665 360102011660 transposase/IS protein; Provisional; Region: PRK09183 360102011661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102011662 Walker A motif; other site 360102011663 ATP binding site [chemical binding]; other site 360102011664 Walker B motif; other site 360102011665 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 360102011666 HTH-like domain; Region: HTH_21; pfam13276 360102011667 Integrase core domain; Region: rve; pfam00665 360102011668 Integrase core domain; Region: rve_3; pfam13683 360102011669 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102011670 DNA-binding interface [nucleotide binding]; DNA binding site 360102011671 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 360102011672 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 360102011673 purine monophosphate binding site [chemical binding]; other site 360102011674 dimer interface [polypeptide binding]; other site 360102011675 putative catalytic residues [active] 360102011676 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 360102011677 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 360102011678 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 360102011679 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 360102011680 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 360102011681 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 360102011682 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 360102011683 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 360102011684 IHF dimer interface [polypeptide binding]; other site 360102011685 IHF - DNA interface [nucleotide binding]; other site 360102011686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 360102011687 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 360102011688 Active_site [active] 360102011689 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 360102011690 substrate binding site [chemical binding]; other site 360102011691 active site 360102011692 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 360102011693 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 360102011694 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 360102011695 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 360102011696 putative NADH binding site [chemical binding]; other site 360102011697 putative active site [active] 360102011698 nudix motif; other site 360102011699 putative metal binding site [ion binding]; other site 360102011700 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 360102011701 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 360102011702 ThiC-associated domain; Region: ThiC-associated; pfam13667 360102011703 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 360102011704 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 360102011705 thiamine phosphate binding site [chemical binding]; other site 360102011706 active site 360102011707 pyrophosphate binding site [ion binding]; other site 360102011708 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 360102011709 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 360102011710 ATP binding site [chemical binding]; other site 360102011711 substrate interface [chemical binding]; other site 360102011712 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 360102011713 thiS-thiF/thiG interaction site; other site 360102011714 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 360102011715 ThiS interaction site; other site 360102011716 putative active site [active] 360102011717 tetramer interface [polypeptide binding]; other site 360102011718 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 360102011719 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102011720 FeS/SAM binding site; other site 360102011721 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 360102011722 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102011723 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 360102011724 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 360102011725 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 360102011726 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 360102011727 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 360102011728 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 360102011729 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 360102011730 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 360102011731 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 360102011732 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 360102011733 DNA binding site [nucleotide binding] 360102011734 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 360102011735 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 360102011736 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 360102011737 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 360102011738 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 360102011739 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 360102011740 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 360102011741 RPB3 interaction site [polypeptide binding]; other site 360102011742 RPB1 interaction site [polypeptide binding]; other site 360102011743 RPB11 interaction site [polypeptide binding]; other site 360102011744 RPB10 interaction site [polypeptide binding]; other site 360102011745 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 360102011746 core dimer interface [polypeptide binding]; other site 360102011747 peripheral dimer interface [polypeptide binding]; other site 360102011748 L10 interface [polypeptide binding]; other site 360102011749 L11 interface [polypeptide binding]; other site 360102011750 putative EF-Tu interaction site [polypeptide binding]; other site 360102011751 putative EF-G interaction site [polypeptide binding]; other site 360102011752 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 360102011753 23S rRNA interface [nucleotide binding]; other site 360102011754 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 360102011755 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 360102011756 mRNA/rRNA interface [nucleotide binding]; other site 360102011757 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 360102011758 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 360102011759 23S rRNA interface [nucleotide binding]; other site 360102011760 L7/L12 interface [polypeptide binding]; other site 360102011761 putative thiostrepton binding site; other site 360102011762 L25 interface [polypeptide binding]; other site 360102011763 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 360102011764 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 360102011765 putative homodimer interface [polypeptide binding]; other site 360102011766 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 360102011767 heterodimer interface [polypeptide binding]; other site 360102011768 homodimer interface [polypeptide binding]; other site 360102011769 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 360102011770 elongation factor Tu; Reviewed; Region: PRK00049 360102011771 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 360102011772 G1 box; other site 360102011773 GEF interaction site [polypeptide binding]; other site 360102011774 GTP/Mg2+ binding site [chemical binding]; other site 360102011775 Switch I region; other site 360102011776 G2 box; other site 360102011777 G3 box; other site 360102011778 Switch II region; other site 360102011779 G4 box; other site 360102011780 G5 box; other site 360102011781 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 360102011782 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 360102011783 Antibiotic Binding Site [chemical binding]; other site 360102011784 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 360102011785 transposase/IS protein; Provisional; Region: PRK09183 360102011786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102011787 Walker A motif; other site 360102011788 ATP binding site [chemical binding]; other site 360102011789 Walker B motif; other site 360102011790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102011791 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102011792 DNA-binding interface [nucleotide binding]; DNA binding site 360102011793 Integrase core domain; Region: rve; pfam00665 360102011794 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 360102011795 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 360102011796 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 360102011797 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 360102011798 Helix-turn-helix domain; Region: HTH_18; pfam12833 360102011799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102011800 ABC-type ribose transport system, auxiliary component [Carbohydrate transport and metabolism]; Region: RbsD; COG1869 360102011801 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 360102011802 substrate binding site [chemical binding]; other site 360102011803 dimer interface [polypeptide binding]; other site 360102011804 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360102011805 ATP binding site [chemical binding]; other site 360102011806 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 360102011807 intersubunit interface [polypeptide binding]; other site 360102011808 active site 360102011809 catalytic residue [active] 360102011810 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 360102011811 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 360102011812 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102011813 substrate binding pocket [chemical binding]; other site 360102011814 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 360102011815 membrane-bound complex binding site; other site 360102011816 hinge residues; other site 360102011817 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 360102011818 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 360102011819 active site 360102011820 dimer interface [polypeptide binding]; other site 360102011821 non-prolyl cis peptide bond; other site 360102011822 insertion regions; other site 360102011823 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 360102011824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102011825 dimer interface [polypeptide binding]; other site 360102011826 conserved gate region; other site 360102011827 putative PBP binding loops; other site 360102011828 ABC-ATPase subunit interface; other site 360102011829 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 360102011830 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 360102011831 Walker A/P-loop; other site 360102011832 ATP binding site [chemical binding]; other site 360102011833 Q-loop/lid; other site 360102011834 ABC transporter signature motif; other site 360102011835 Walker B; other site 360102011836 D-loop; other site 360102011837 H-loop/switch region; other site 360102011838 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 360102011839 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 360102011840 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 360102011841 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 360102011842 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 360102011843 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 360102011844 putative acyl-acceptor binding pocket; other site 360102011845 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 360102011846 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 360102011847 ligand binding site [chemical binding]; other site 360102011848 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360102011849 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102011850 Walker A/P-loop; other site 360102011851 ATP binding site [chemical binding]; other site 360102011852 Q-loop/lid; other site 360102011853 ABC transporter signature motif; other site 360102011854 Walker B; other site 360102011855 D-loop; other site 360102011856 H-loop/switch region; other site 360102011857 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102011858 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102011859 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102011860 TM-ABC transporter signature motif; other site 360102011861 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102011862 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102011863 TM-ABC transporter signature motif; other site 360102011864 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 360102011865 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 360102011866 N- and C-terminal domain interface [polypeptide binding]; other site 360102011867 active site 360102011868 MgATP binding site [chemical binding]; other site 360102011869 catalytic site [active] 360102011870 metal binding site [ion binding]; metal-binding site 360102011871 carbohydrate binding site [chemical binding]; other site 360102011872 putative homodimer interface [polypeptide binding]; other site 360102011873 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 360102011874 putative active site [active] 360102011875 putative S-transferase; Provisional; Region: PRK11752 360102011876 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 360102011877 C-terminal domain interface [polypeptide binding]; other site 360102011878 GSH binding site (G-site) [chemical binding]; other site 360102011879 dimer interface [polypeptide binding]; other site 360102011880 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 360102011881 dimer interface [polypeptide binding]; other site 360102011882 N-terminal domain interface [polypeptide binding]; other site 360102011883 active site 360102011884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 360102011885 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 360102011886 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102011887 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 360102011888 DNA-binding site [nucleotide binding]; DNA binding site 360102011889 RNA-binding motif; other site 360102011890 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 360102011891 DNA-binding site [nucleotide binding]; DNA binding site 360102011892 RNA-binding motif; other site 360102011893 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 360102011894 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 360102011895 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 360102011896 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 360102011897 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 360102011898 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 360102011899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102011900 metabolite-proton symporter; Region: 2A0106; TIGR00883 360102011901 putative substrate translocation pore; other site 360102011902 Transcriptional regulators [Transcription]; Region: GntR; COG1802 360102011903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 360102011904 DNA-binding site [nucleotide binding]; DNA binding site 360102011905 FCD domain; Region: FCD; pfam07729 360102011906 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 360102011907 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 360102011908 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 360102011909 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 360102011910 FMN binding site [chemical binding]; other site 360102011911 active site 360102011912 catalytic residues [active] 360102011913 substrate binding site [chemical binding]; other site 360102011914 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 360102011915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 360102011916 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 360102011917 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 360102011918 Na binding site [ion binding]; other site 360102011919 hypothetical protein; Provisional; Region: PRK10633 360102011920 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 360102011921 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360102011922 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 360102011923 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 360102011924 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 360102011925 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 360102011926 carboxyltransferase (CT) interaction site; other site 360102011927 biotinylation site [posttranslational modification]; other site 360102011928 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 360102011929 Dehydroquinase class II; Region: DHquinase_II; pfam01220 360102011930 active site 360102011931 trimer interface [polypeptide binding]; other site 360102011932 dimer interface [polypeptide binding]; other site 360102011933 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 360102011934 TMAO/DMSO reductase; Reviewed; Region: PRK05363 360102011935 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 360102011936 Moco binding site; other site 360102011937 metal coordination site [ion binding]; other site 360102011938 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 360102011939 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 360102011940 NADP binding site [chemical binding]; other site 360102011941 dimer interface [polypeptide binding]; other site 360102011942 regulatory protein CsrD; Provisional; Region: PRK11059 360102011943 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360102011944 metal binding site [ion binding]; metal-binding site 360102011945 active site 360102011946 I-site; other site 360102011947 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360102011948 rod shape-determining protein MreB; Provisional; Region: PRK13927 360102011949 MreB and similar proteins; Region: MreB_like; cd10225 360102011950 nucleotide binding site [chemical binding]; other site 360102011951 Mg binding site [ion binding]; other site 360102011952 putative protofilament interaction site [polypeptide binding]; other site 360102011953 RodZ interaction site [polypeptide binding]; other site 360102011954 rod shape-determining protein MreC; Region: mreC; TIGR00219 360102011955 rod shape-determining protein MreC; Region: MreC; pfam04085 360102011956 rod shape-determining protein MreD; Provisional; Region: PRK11060 360102011957 Maf-like protein; Region: Maf; pfam02545 360102011958 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 360102011959 active site 360102011960 dimer interface [polypeptide binding]; other site 360102011961 ribonuclease G; Provisional; Region: PRK11712 360102011962 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 360102011963 homodimer interface [polypeptide binding]; other site 360102011964 oligonucleotide binding site [chemical binding]; other site 360102011965 hypothetical protein; Provisional; Region: PRK10899 360102011966 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 360102011967 nitrilase; Region: PLN02798 360102011968 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 360102011969 putative active site [active] 360102011970 catalytic triad [active] 360102011971 dimer interface [polypeptide binding]; other site 360102011972 protease TldD; Provisional; Region: tldD; PRK10735 360102011973 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 360102011974 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 360102011975 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 360102011976 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 360102011977 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 360102011978 active site 360102011979 catalytic residues [active] 360102011980 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 360102011981 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 360102011982 Family description; Region: VCBS; pfam13517 360102011983 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 360102011984 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 360102011985 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 360102011986 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102011987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102011988 transcriptional regulator; Provisional; Region: PRK10632 360102011989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102011990 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 360102011991 putative effector binding pocket; other site 360102011992 dimerization interface [polypeptide binding]; other site 360102011993 efflux system membrane protein; Provisional; Region: PRK11594 360102011994 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 360102011995 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 360102011996 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102011997 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 360102011998 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 360102011999 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 360102012000 tetramerization interface [polypeptide binding]; other site 360102012001 NAD(P) binding site [chemical binding]; other site 360102012002 catalytic residues [active] 360102012003 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 360102012004 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 360102012005 active site 360102012006 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 360102012007 RNAase interaction site [polypeptide binding]; other site 360102012008 hypothetical protein; Provisional; Region: PRK05255 360102012009 peptidase PmbA; Provisional; Region: PRK11040 360102012010 Soluble cytochrome b562 [Energy production and conversion]; Region: CybC; COG3783 360102012011 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 360102012012 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 360102012013 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 360102012014 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 360102012015 Ca binding site [ion binding]; other site 360102012016 active site 360102012017 catalytic site [active] 360102012018 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 360102012019 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 360102012020 active site turn [active] 360102012021 phosphorylation site [posttranslational modification] 360102012022 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 360102012023 trehalose repressor; Provisional; Region: treR; PRK09492 360102012024 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102012025 DNA binding site [nucleotide binding] 360102012026 domain linker motif; other site 360102012027 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 360102012028 dimerization interface [polypeptide binding]; other site 360102012029 ligand binding site [chemical binding]; other site 360102012030 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 360102012031 dimer interface [polypeptide binding]; other site 360102012032 putative inhibitory loop; other site 360102012033 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 360102012034 homotrimer interaction site [polypeptide binding]; other site 360102012035 putative active site [active] 360102012036 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 360102012037 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 360102012038 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 360102012039 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 360102012040 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 360102012041 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 360102012042 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 360102012043 dimerization domain swap beta strand [polypeptide binding]; other site 360102012044 regulatory protein interface [polypeptide binding]; other site 360102012045 active site 360102012046 regulatory phosphorylation site [posttranslational modification]; other site 360102012047 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 360102012048 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 360102012049 active site 360102012050 phosphorylation site [posttranslational modification] 360102012051 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 360102012052 30S subunit binding site; other site 360102012053 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 360102012054 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 360102012055 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 360102012056 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 360102012057 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 360102012058 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 360102012059 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 360102012060 Walker A/P-loop; other site 360102012061 ATP binding site [chemical binding]; other site 360102012062 Q-loop/lid; other site 360102012063 ABC transporter signature motif; other site 360102012064 Walker B; other site 360102012065 D-loop; other site 360102012066 H-loop/switch region; other site 360102012067 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 360102012068 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 360102012069 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 360102012070 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 360102012071 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 360102012072 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 360102012073 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 360102012074 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 360102012075 putative active site [active] 360102012076 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 360102012077 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 360102012078 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 360102012079 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 360102012080 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 360102012081 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 360102012082 Walker A/P-loop; other site 360102012083 ATP binding site [chemical binding]; other site 360102012084 Q-loop/lid; other site 360102012085 ABC transporter signature motif; other site 360102012086 Walker B; other site 360102012087 D-loop; other site 360102012088 H-loop/switch region; other site 360102012089 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 360102012090 conserved hypothetical integral membrane protein; Region: TIGR00056 360102012091 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 360102012092 mce related protein; Region: MCE; pfam02470 360102012093 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 360102012094 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 360102012095 anti sigma factor interaction site; other site 360102012096 regulatory phosphorylation site [posttranslational modification]; other site 360102012097 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 360102012098 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 360102012099 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 360102012100 hinge; other site 360102012101 active site 360102012102 serine endoprotease; Provisional; Region: PRK10898 360102012103 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 360102012104 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360102012105 protein binding site [polypeptide binding]; other site 360102012106 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102012107 serine endoprotease; Provisional; Region: PRK10139 360102012108 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 360102012109 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360102012110 protein binding site [polypeptide binding]; other site 360102012111 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 360102012112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 360102012113 hypothetical protein; Provisional; Region: PRK11677 360102012114 Predicted ATPase [General function prediction only]; Region: COG1485 360102012115 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 360102012116 23S rRNA interface [nucleotide binding]; other site 360102012117 L3 interface [polypeptide binding]; other site 360102012118 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 360102012119 stringent starvation protein A; Provisional; Region: sspA; PRK09481 360102012120 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 360102012121 C-terminal domain interface [polypeptide binding]; other site 360102012122 putative GSH binding site (G-site) [chemical binding]; other site 360102012123 dimer interface [polypeptide binding]; other site 360102012124 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 360102012125 dimer interface [polypeptide binding]; other site 360102012126 N-terminal domain interface [polypeptide binding]; other site 360102012127 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 360102012128 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 360102012129 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 360102012130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 360102012131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360102012132 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 360102012133 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 360102012134 active site 360102012135 dimer interface [polypeptide binding]; other site 360102012136 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 360102012137 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 360102012138 active site 360102012139 FMN binding site [chemical binding]; other site 360102012140 substrate binding site [chemical binding]; other site 360102012141 3Fe-4S cluster binding site [ion binding]; other site 360102012142 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 360102012143 domain interface; other site 360102012144 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 360102012145 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102012146 FeS/SAM binding site; other site 360102012147 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 360102012148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 360102012149 putative active site [active] 360102012150 heme pocket [chemical binding]; other site 360102012151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102012152 dimer interface [polypeptide binding]; other site 360102012153 phosphorylation site [posttranslational modification] 360102012154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102012155 ATP binding site [chemical binding]; other site 360102012156 Mg2+ binding site [ion binding]; other site 360102012157 G-X-G motif; other site 360102012158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102012159 active site 360102012160 phosphorylation site [posttranslational modification] 360102012161 intermolecular recognition site; other site 360102012162 dimerization interface [polypeptide binding]; other site 360102012163 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 360102012164 putative binding surface; other site 360102012165 active site 360102012166 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 360102012167 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 360102012168 conserved cys residue [active] 360102012169 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 360102012170 Transglycosylase; Region: Transgly; cl17702 360102012171 outer membrane lipoprotein; Provisional; Region: PRK11023 360102012172 BON domain; Region: BON; pfam04972 360102012173 BON domain; Region: BON; cl02771 360102012174 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 360102012175 dimer interface [polypeptide binding]; other site 360102012176 active site 360102012177 hypothetical protein; Reviewed; Region: PRK12497 360102012178 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 360102012179 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 360102012180 putative ligand binding site [chemical binding]; other site 360102012181 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 360102012182 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 360102012183 putative SAM binding site [chemical binding]; other site 360102012184 putative homodimer interface [polypeptide binding]; other site 360102012185 Pirin-related protein [General function prediction only]; Region: COG1741 360102012186 Pirin; Region: Pirin; pfam02678 360102012187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102012188 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 360102012189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 360102012190 dimerization interface [polypeptide binding]; other site 360102012191 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 360102012192 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 360102012193 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 360102012194 putative dimer interface [polypeptide binding]; other site 360102012195 N-terminal domain interface [polypeptide binding]; other site 360102012196 putative substrate binding pocket (H-site) [chemical binding]; other site 360102012197 transposase/IS protein; Provisional; Region: PRK09183 360102012198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102012199 Walker A motif; other site 360102012200 ATP binding site [chemical binding]; other site 360102012201 Walker B motif; other site 360102012202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102012203 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102012204 DNA-binding interface [nucleotide binding]; DNA binding site 360102012205 Integrase core domain; Region: rve; pfam00665 360102012206 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102012207 putative transposase OrfB; Reviewed; Region: PHA02517 360102012208 HTH-like domain; Region: HTH_21; pfam13276 360102012209 Integrase core domain; Region: rve; pfam00665 360102012210 Integrase core domain; Region: rve_2; pfam13333 360102012211 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 360102012212 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 360102012213 glycogen phosphorylase; Provisional; Region: PRK14986 360102012214 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 360102012215 homodimer interface [polypeptide binding]; other site 360102012216 active site pocket [active] 360102012217 glycogen synthase; Provisional; Region: glgA; PRK00654 360102012218 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 360102012219 ADP-binding pocket [chemical binding]; other site 360102012220 homodimer interface [polypeptide binding]; other site 360102012221 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 360102012222 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 360102012223 ligand binding site; other site 360102012224 oligomer interface; other site 360102012225 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 360102012226 sulfate 1 binding site; other site 360102012227 glycogen debranching enzyme; Provisional; Region: PRK03705 360102012228 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 360102012229 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 360102012230 active site 360102012231 catalytic site [active] 360102012232 glycogen branching enzyme; Provisional; Region: PRK05402 360102012233 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 360102012234 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 360102012235 active site 360102012236 catalytic site [active] 360102012237 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 360102012238 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 360102012239 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 360102012240 Histidine kinase; Region: His_kinase; pfam06580 360102012241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102012242 ATP binding site [chemical binding]; other site 360102012243 Mg2+ binding site [ion binding]; other site 360102012244 G-X-G motif; other site 360102012245 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360102012246 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 360102012247 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 360102012248 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 360102012249 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 360102012250 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 360102012251 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 360102012252 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 360102012253 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 360102012254 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 360102012255 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 360102012256 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 360102012257 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 360102012258 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 360102012259 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 360102012260 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 360102012261 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 360102012262 putative antibiotic transporter; Provisional; Region: PRK10739 360102012263 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 360102012264 AAA domain; Region: AAA_33; pfam13671 360102012265 ATP-binding site [chemical binding]; other site 360102012266 Gluconate-6-phosphate binding site [chemical binding]; other site 360102012267 high-affinity gluconate transporter; Provisional; Region: PRK14984 360102012268 gluconate transporter; Region: gntP; TIGR00791 360102012269 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 360102012270 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 360102012271 DNA binding site [nucleotide binding] 360102012272 domain linker motif; other site 360102012273 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 360102012274 putative ligand binding site [chemical binding]; other site 360102012275 putative dimerization interface [polypeptide binding]; other site 360102012276 Pirin-related protein [General function prediction only]; Region: COG1741 360102012277 Pirin; Region: Pirin; pfam02678 360102012278 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 360102012279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102012280 active site 360102012281 phosphorylation site [posttranslational modification] 360102012282 intermolecular recognition site; other site 360102012283 dimerization interface [polypeptide binding]; other site 360102012284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102012285 DNA binding site [nucleotide binding] 360102012286 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 360102012287 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360102012288 substrate binding site [chemical binding]; other site 360102012289 ATP binding site [chemical binding]; other site 360102012290 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 360102012291 intersubunit interface [polypeptide binding]; other site 360102012292 active site 360102012293 zinc binding site [ion binding]; other site 360102012294 Na+ binding site [ion binding]; other site 360102012295 ABC-type sugar transport system, auxiliary component [General function prediction only]; Region: COG3822 360102012296 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 360102012297 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 360102012298 putative ligand binding site [chemical binding]; other site 360102012299 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102012300 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102012301 TM-ABC transporter signature motif; other site 360102012302 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 360102012303 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102012304 Walker A/P-loop; other site 360102012305 ATP binding site [chemical binding]; other site 360102012306 Q-loop/lid; other site 360102012307 ABC transporter signature motif; other site 360102012308 Walker B; other site 360102012309 D-loop; other site 360102012310 H-loop/switch region; other site 360102012311 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102012312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 360102012313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 360102012314 dimerization interface [polypeptide binding]; other site 360102012315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102012316 dimer interface [polypeptide binding]; other site 360102012317 phosphorylation site [posttranslational modification] 360102012318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102012319 ATP binding site [chemical binding]; other site 360102012320 Mg2+ binding site [ion binding]; other site 360102012321 G-X-G motif; other site 360102012322 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 360102012323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102012324 active site 360102012325 phosphorylation site [posttranslational modification] 360102012326 intermolecular recognition site; other site 360102012327 dimerization interface [polypeptide binding]; other site 360102012328 Predicted flavoproteins [General function prediction only]; Region: COG2081 360102012329 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360102012330 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 360102012331 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 360102012332 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102012333 universal stress protein UspB; Provisional; Region: PRK04960 360102012334 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 360102012335 Ligand Binding Site [chemical binding]; other site 360102012336 glutamate dehydrogenase; Provisional; Region: PRK09414 360102012337 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 360102012338 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 360102012339 NAD(P) binding site [chemical binding]; other site 360102012340 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 360102012341 active site 360102012342 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 360102012343 putative methyltransferase; Provisional; Region: PRK10742 360102012344 oligopeptidase A; Provisional; Region: PRK10911 360102012345 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 360102012346 active site 360102012347 Zn binding site [ion binding]; other site 360102012348 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 360102012349 glutathione reductase; Validated; Region: PRK06116 360102012350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360102012351 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 360102012352 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 360102012353 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 360102012354 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 360102012355 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 360102012356 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 360102012357 fructuronate transporter; Provisional; Region: PRK10034; cl15264 360102012358 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 360102012359 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 360102012360 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 360102012361 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 360102012362 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 360102012363 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 360102012364 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 360102012365 Autotransporter beta-domain; Region: Autotransporter; smart00869 360102012366 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 360102012367 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 360102012368 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 360102012369 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 360102012370 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360102012371 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 360102012372 active site 1 [active] 360102012373 dimer interface [polypeptide binding]; other site 360102012374 hexamer interface [polypeptide binding]; other site 360102012375 active site 2 [active] 360102012376 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 360102012377 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 360102012378 substrate binding site [chemical binding]; other site 360102012379 ATP binding site [chemical binding]; other site 360102012380 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 360102012381 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 360102012382 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 360102012383 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 360102012384 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 360102012385 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 360102012386 sugar binding site [chemical binding]; other site 360102012387 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 360102012388 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 360102012389 biofilm formation regulator HmsP; Provisional; Region: PRK11829 360102012390 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360102012391 metal binding site [ion binding]; metal-binding site 360102012392 active site 360102012393 I-site; other site 360102012394 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 360102012395 endo-1,4-D-glucanase; Provisional; Region: PRK11097 360102012396 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 360102012397 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102012398 Walker A/P-loop; other site 360102012399 ATP binding site [chemical binding]; other site 360102012400 Q-loop/lid; other site 360102012401 ABC transporter signature motif; other site 360102012402 Walker B; other site 360102012403 D-loop; other site 360102012404 H-loop/switch region; other site 360102012405 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 360102012406 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 360102012407 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 360102012408 Walker A/P-loop; other site 360102012409 ATP binding site [chemical binding]; other site 360102012410 Q-loop/lid; other site 360102012411 ABC transporter signature motif; other site 360102012412 Walker B; other site 360102012413 D-loop; other site 360102012414 H-loop/switch region; other site 360102012415 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 360102012416 dipeptide transporter; Provisional; Region: PRK10913 360102012417 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 360102012418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102012419 dimer interface [polypeptide binding]; other site 360102012420 conserved gate region; other site 360102012421 putative PBP binding loops; other site 360102012422 ABC-ATPase subunit interface; other site 360102012423 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 360102012424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102012425 dimer interface [polypeptide binding]; other site 360102012426 conserved gate region; other site 360102012427 putative PBP binding loops; other site 360102012428 ABC-ATPase subunit interface; other site 360102012429 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 360102012430 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 360102012431 peptide binding site [polypeptide binding]; other site 360102012432 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 360102012433 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 360102012434 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 360102012435 haemagglutination activity domain; Region: Haemagg_act; pfam05860 360102012436 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102012437 regulatory protein UhpC; Provisional; Region: PRK11663 360102012438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102012439 putative substrate translocation pore; other site 360102012440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102012441 Histidine kinase; Region: HisKA_3; pfam07730 360102012442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102012443 ATP binding site [chemical binding]; other site 360102012444 Mg2+ binding site [ion binding]; other site 360102012445 G-X-G motif; other site 360102012446 transposase/IS protein; Provisional; Region: PRK09183 360102012447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102012448 Walker A motif; other site 360102012449 ATP binding site [chemical binding]; other site 360102012450 Walker B motif; other site 360102012451 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102012452 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102012453 DNA-binding interface [nucleotide binding]; DNA binding site 360102012454 Integrase core domain; Region: rve; pfam00665 360102012455 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 360102012456 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 360102012457 Fic family protein [Function unknown]; Region: COG3177 360102012458 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 360102012459 Fic/DOC family; Region: Fic; pfam02661 360102012460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360102012461 non-specific DNA binding site [nucleotide binding]; other site 360102012462 salt bridge; other site 360102012463 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 360102012464 sequence-specific DNA binding site [nucleotide binding]; other site 360102012465 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 360102012466 active site 360102012467 nucleotide binding site [chemical binding]; other site 360102012468 HIGH motif; other site 360102012469 KMSKS motif; other site 360102012470 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 360102012471 DNA repair protein RadA; Provisional; Region: PRK11823 360102012472 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 360102012473 Walker A motif/ATP binding site; other site 360102012474 ATP binding site [chemical binding]; other site 360102012475 Walker B motif; other site 360102012476 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 360102012477 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 360102012478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102012479 motif II; other site 360102012480 hypothetical protein; Provisional; Region: PRK11246 360102012481 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 360102012482 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 360102012483 phosphopentomutase; Provisional; Region: PRK05362 360102012484 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 360102012485 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 360102012486 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 360102012487 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 360102012488 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 360102012489 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 360102012490 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 360102012491 intersubunit interface [polypeptide binding]; other site 360102012492 active site 360102012493 catalytic residue [active] 360102012494 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 360102012495 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 360102012496 Nucleoside recognition; Region: Gate; pfam07670 360102012497 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 360102012498 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 360102012499 active site 360102012500 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 360102012501 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 360102012502 active site 360102012503 nucleophile elbow; other site 360102012504 periplasmic protein; Provisional; Region: PRK10568 360102012505 BON domain; Region: BON; pfam04972 360102012506 BON domain; Region: BON; pfam04972 360102012507 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 360102012508 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 360102012509 G1 box; other site 360102012510 putative GEF interaction site [polypeptide binding]; other site 360102012511 GTP/Mg2+ binding site [chemical binding]; other site 360102012512 Switch I region; other site 360102012513 G2 box; other site 360102012514 G3 box; other site 360102012515 Switch II region; other site 360102012516 G4 box; other site 360102012517 G5 box; other site 360102012518 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 360102012519 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 360102012520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 360102012521 Coenzyme A binding pocket [chemical binding]; other site 360102012522 DNA polymerase III subunit psi; Validated; Region: PRK06856 360102012523 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 360102012524 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 360102012525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102012526 S-adenosylmethionine binding site [chemical binding]; other site 360102012527 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 360102012528 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 360102012529 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360102012530 metal binding site [ion binding]; metal-binding site 360102012531 active site 360102012532 I-site; other site 360102012533 Pectinesterase; Region: Pectinesterase; pfam01095 360102012534 putative pectinesterase; Region: PLN02432; cl01911 360102012535 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 360102012536 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 360102012537 Peptidase family M23; Region: Peptidase_M23; pfam01551 360102012538 HlyD family secretion protein; Region: HlyD_3; pfam13437 360102012539 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 360102012540 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 360102012541 O-Antigen ligase; Region: Wzy_C; pfam04932 360102012542 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 360102012543 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 360102012544 putative active site [active] 360102012545 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 360102012546 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 360102012547 putative N- and C-terminal domain interface [polypeptide binding]; other site 360102012548 putative active site [active] 360102012549 putative MgATP binding site [chemical binding]; other site 360102012550 catalytic site [active] 360102012551 metal binding site [ion binding]; metal-binding site 360102012552 putative carbohydrate binding site [chemical binding]; other site 360102012553 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 360102012554 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 360102012555 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 360102012556 non-specific DNA interactions [nucleotide binding]; other site 360102012557 DNA binding site [nucleotide binding] 360102012558 sequence specific DNA binding site [nucleotide binding]; other site 360102012559 putative cAMP binding site [chemical binding]; other site 360102012560 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 360102012561 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102012562 Walker A/P-loop; other site 360102012563 ATP binding site [chemical binding]; other site 360102012564 Q-loop/lid; other site 360102012565 ABC transporter signature motif; other site 360102012566 Walker B; other site 360102012567 D-loop; other site 360102012568 H-loop/switch region; other site 360102012569 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102012570 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102012571 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102012572 TM-ABC transporter signature motif; other site 360102012573 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102012574 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102012575 TM-ABC transporter signature motif; other site 360102012576 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 360102012577 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 360102012578 ligand binding site [chemical binding]; other site 360102012579 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 360102012580 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 360102012581 putative active site; other site 360102012582 catalytic residue [active] 360102012583 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 360102012584 hypothetical protein; Provisional; Region: PRK11667 360102012585 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 360102012586 dimerization domain swap beta strand [polypeptide binding]; other site 360102012587 regulatory protein interface [polypeptide binding]; other site 360102012588 active site 360102012589 regulatory phosphorylation site [posttranslational modification]; other site 360102012590 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 360102012591 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 360102012592 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 360102012593 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 360102012594 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 360102012595 active site 360102012596 phosphorylation site [posttranslational modification] 360102012597 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 360102012598 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 360102012599 active site 360102012600 P-loop; other site 360102012601 phosphorylation site [posttranslational modification] 360102012602 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 360102012603 active site 360102012604 P-loop; other site 360102012605 phosphorylation site [posttranslational modification] 360102012606 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 360102012607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102012608 Predicted membrane protein [Function unknown]; Region: COG4269 360102012609 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 360102012610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 360102012611 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 360102012612 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 360102012613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 360102012614 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 360102012615 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 360102012616 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 360102012617 ATP binding site [chemical binding]; other site 360102012618 Mg2+ binding site [ion binding]; other site 360102012619 G-X-G motif; other site 360102012620 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 360102012621 Methyltransferase domain; Region: Methyltransf_26; pfam13659 360102012622 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 360102012623 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 360102012624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 360102012625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 360102012626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102012627 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102012628 DNA-binding interface [nucleotide binding]; DNA binding site 360102012629 Integrase core domain; Region: rve; pfam00665 360102012630 transposase/IS protein; Provisional; Region: PRK09183 360102012631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102012632 Walker A motif; other site 360102012633 ATP binding site [chemical binding]; other site 360102012634 Walker B motif; other site 360102012635 esterase; Provisional; Region: PRK10566 360102012636 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 360102012637 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 360102012638 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 360102012639 active site 360102012640 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 360102012641 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 360102012642 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 360102012643 exoribonuclease R; Provisional; Region: PRK11642 360102012644 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 360102012645 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 360102012646 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 360102012647 RNB domain; Region: RNB; pfam00773 360102012648 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 360102012649 RNA binding site [nucleotide binding]; other site 360102012650 transcriptional repressor NsrR; Provisional; Region: PRK11014 360102012651 Rrf2 family protein; Region: rrf2_super; TIGR00738 360102012652 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 360102012653 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 360102012654 GDP-binding site [chemical binding]; other site 360102012655 ACT binding site; other site 360102012656 IMP binding site; other site 360102012657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 360102012658 FtsH protease regulator HflC; Provisional; Region: PRK11029 360102012659 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 360102012660 FtsH protease regulator HflK; Provisional; Region: PRK10930 360102012661 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 360102012662 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 360102012663 GTPase HflX; Provisional; Region: PRK11058 360102012664 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 360102012665 HflX GTPase family; Region: HflX; cd01878 360102012666 G1 box; other site 360102012667 GTP/Mg2+ binding site [chemical binding]; other site 360102012668 Switch I region; other site 360102012669 G2 box; other site 360102012670 G3 box; other site 360102012671 Switch II region; other site 360102012672 G4 box; other site 360102012673 G5 box; other site 360102012674 bacterial Hfq-like; Region: Hfq; cd01716 360102012675 hexamer interface [polypeptide binding]; other site 360102012676 Sm1 motif; other site 360102012677 RNA binding site [nucleotide binding]; other site 360102012678 Sm2 motif; other site 360102012679 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 360102012680 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 360102012681 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 360102012682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102012683 ATP binding site [chemical binding]; other site 360102012684 Mg2+ binding site [ion binding]; other site 360102012685 G-X-G motif; other site 360102012686 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 360102012687 ATP binding site [chemical binding]; other site 360102012688 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 360102012689 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 360102012690 AMIN domain; Region: AMIN; pfam11741 360102012691 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 360102012692 active site 360102012693 metal binding site [ion binding]; metal-binding site 360102012694 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 360102012695 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360102012696 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 360102012697 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 360102012698 ADP-binding protein; Provisional; Region: PRK10646 360102012699 putative carbohydrate kinase; Provisional; Region: PRK10565 360102012700 Uncharacterized conserved protein [Function unknown]; Region: COG0062 360102012701 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 360102012702 putative substrate binding site [chemical binding]; other site 360102012703 putative ATP binding site [chemical binding]; other site 360102012704 epoxyqueuosine reductase; Region: TIGR00276 360102012705 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 360102012706 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 360102012707 catalytic site [active] 360102012708 putative active site [active] 360102012709 putative substrate binding site [chemical binding]; other site 360102012710 dimer interface [polypeptide binding]; other site 360102012711 GTPase RsgA; Reviewed; Region: PRK12288 360102012712 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 360102012713 RNA binding site [nucleotide binding]; other site 360102012714 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 360102012715 GTPase/Zn-binding domain interface [polypeptide binding]; other site 360102012716 GTP/Mg2+ binding site [chemical binding]; other site 360102012717 G4 box; other site 360102012718 G5 box; other site 360102012719 G1 box; other site 360102012720 Switch I region; other site 360102012721 G2 box; other site 360102012722 G3 box; other site 360102012723 Switch II region; other site 360102012724 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 360102012725 putative mechanosensitive channel protein; Provisional; Region: PRK10929 360102012726 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 360102012727 Mechanosensitive ion channel; Region: MS_channel; pfam00924 360102012728 poxB regulator PoxA; Provisional; Region: PRK09350 360102012729 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 360102012730 motif 1; other site 360102012731 dimer interface [polypeptide binding]; other site 360102012732 active site 360102012733 motif 2; other site 360102012734 motif 3; other site 360102012735 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 360102012736 L-aspartate oxidase; Provisional; Region: PRK06175 360102012737 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 360102012738 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 360102012739 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 360102012740 catalytic loop [active] 360102012741 iron binding site [ion binding]; other site 360102012742 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 360102012743 D-subunit interface [polypeptide binding]; other site 360102012744 Iron-sulfur protein interface; other site 360102012745 proximal quinone binding site [chemical binding]; other site 360102012746 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 360102012747 Iron-sulfur protein interface; other site 360102012748 proximal quinone binding site [chemical binding]; other site 360102012749 C-subunit interface; other site 360102012750 distal quinone binding site; other site 360102012751 multidrug efflux system protein; Provisional; Region: PRK11431 360102012752 elongation factor P; Validated; Region: PRK00529 360102012753 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 360102012754 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 360102012755 RNA binding site [nucleotide binding]; other site 360102012756 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 360102012757 RNA binding site [nucleotide binding]; other site 360102012758 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 360102012759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102012760 FeS/SAM binding site; other site 360102012761 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 360102012762 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 360102012763 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 360102012764 ring oligomerisation interface [polypeptide binding]; other site 360102012765 ATP/Mg binding site [chemical binding]; other site 360102012766 stacking interactions; other site 360102012767 hinge regions; other site 360102012768 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 360102012769 oligomerisation interface [polypeptide binding]; other site 360102012770 mobile loop; other site 360102012771 roof hairpin; other site 360102012772 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 360102012773 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 360102012774 Aspartase; Region: Aspartase; cd01357 360102012775 active sites [active] 360102012776 tetramer interface [polypeptide binding]; other site 360102012777 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 360102012778 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 360102012779 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 360102012780 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 360102012781 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 360102012782 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 360102012783 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 360102012784 DsbD alpha interface [polypeptide binding]; other site 360102012785 catalytic residues [active] 360102012786 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 360102012787 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 360102012788 [4Fe-4S] binding site [ion binding]; other site 360102012789 molybdopterin cofactor binding site; other site 360102012790 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 360102012791 molybdopterin cofactor binding site; other site 360102012792 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 360102012793 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 360102012794 4Fe-4S binding domain; Region: Fer4; pfam00037 360102012795 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 360102012796 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 360102012797 putative transcriptional regulator; Provisional; Region: PRK11640 360102012798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 360102012799 Viral enhancin protein; Region: Enhancin; pfam03272 360102012800 Peptidase M60-like family; Region: M60-like; pfam13402 360102012801 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 360102012802 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 360102012803 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 360102012804 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 360102012805 transcriptional activator RhaR; Provisional; Region: PRK13501 360102012806 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 360102012807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102012808 transcriptional activator RhaS; Provisional; Region: PRK13503 360102012809 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 360102012810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102012811 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 360102012812 N- and C-terminal domain interface [polypeptide binding]; other site 360102012813 active site 360102012814 putative catalytic site [active] 360102012815 metal binding site [ion binding]; metal-binding site 360102012816 ATP binding site [chemical binding]; other site 360102012817 rhamnulokinase; Provisional; Region: rhaB; PRK10640 360102012818 carbohydrate binding site [chemical binding]; other site 360102012819 L-rhamnose isomerase; Provisional; Region: PRK01076 360102012820 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 360102012821 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 360102012822 intersubunit interface [polypeptide binding]; other site 360102012823 active site 360102012824 Zn2+ binding site [ion binding]; other site 360102012825 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 360102012826 active site 360102012827 NAD binding site [chemical binding]; other site 360102012828 transposase/IS protein; Provisional; Region: PRK09183 360102012829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102012830 Walker A motif; other site 360102012831 ATP binding site [chemical binding]; other site 360102012832 Walker B motif; other site 360102012833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102012834 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102012835 DNA-binding interface [nucleotide binding]; DNA binding site 360102012836 Integrase core domain; Region: rve; pfam00665 360102012837 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 360102012838 metal binding site [ion binding]; metal-binding site 360102012839 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 360102012840 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 360102012841 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 360102012842 dimer interface [polypeptide binding]; other site 360102012843 ssDNA binding site [nucleotide binding]; other site 360102012844 tetramer (dimer of dimers) interface [polypeptide binding]; other site 360102012845 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 360102012846 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 360102012847 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 360102012848 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 360102012849 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 360102012850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 360102012851 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 360102012852 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 360102012853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102012854 homodimer interface [polypeptide binding]; other site 360102012855 catalytic residue [active] 360102012856 alanine racemase; Reviewed; Region: alr; PRK00053 360102012857 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 360102012858 active site 360102012859 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 360102012860 substrate binding site [chemical binding]; other site 360102012861 catalytic residues [active] 360102012862 dimer interface [polypeptide binding]; other site 360102012863 replicative DNA helicase; Provisional; Region: PRK08006 360102012864 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 360102012865 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 360102012866 Walker A motif; other site 360102012867 ATP binding site [chemical binding]; other site 360102012868 Walker B motif; other site 360102012869 DNA binding loops [nucleotide binding] 360102012870 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 360102012871 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 360102012872 NADP binding site [chemical binding]; other site 360102012873 dimer interface [polypeptide binding]; other site 360102012874 phage shock protein G; Reviewed; Region: pspG; PRK09459 360102012875 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 360102012876 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 360102012877 FMN binding site [chemical binding]; other site 360102012878 active site 360102012879 catalytic residues [active] 360102012880 substrate binding site [chemical binding]; other site 360102012881 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 360102012882 metal binding site 2 [ion binding]; metal-binding site 360102012883 putative DNA binding helix; other site 360102012884 metal binding site 1 [ion binding]; metal-binding site 360102012885 dimer interface [polypeptide binding]; other site 360102012886 structural Zn2+ binding site [ion binding]; other site 360102012887 LexA repressor; Validated; Region: PRK00215 360102012888 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 360102012889 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 360102012890 Catalytic site [active] 360102012891 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 360102012892 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 360102012893 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 360102012894 putative acyl-acceptor binding pocket; other site 360102012895 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 360102012896 UbiA prenyltransferase family; Region: UbiA; pfam01040 360102012897 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 360102012898 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 360102012899 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 360102012900 Autotransporter beta-domain; Region: Autotransporter; smart00869 360102012901 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 360102012902 Berberine and berberine like; Region: BBE; pfam08031 360102012903 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 360102012904 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 360102012905 Interdomain contacts; other site 360102012906 Cytokine receptor motif; other site 360102012907 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 360102012908 putative fimbrial chaperone protein; Provisional; Region: PRK09918 360102012909 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102012910 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 360102012911 PapC N-terminal domain; Region: PapC_N; pfam13954 360102012912 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102012913 PapC C-terminal domain; Region: PapC_C; pfam13953 360102012914 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 360102012915 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 360102012916 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 360102012917 putative metal binding site [ion binding]; other site 360102012918 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 360102012919 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 360102012920 putative metal binding site [ion binding]; other site 360102012921 Integral membrane protein TerC family; Region: TerC; cl10468 360102012922 tellurite resistance protein terB; Region: terB; cd07176 360102012923 putative metal binding site [ion binding]; other site 360102012924 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 360102012925 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 360102012926 putative metal binding site [ion binding]; other site 360102012927 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 360102012928 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 360102012929 putative metal binding site [ion binding]; other site 360102012930 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 360102012931 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 360102012932 putative metal binding site [ion binding]; other site 360102012933 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 360102012934 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360102012935 active site 360102012936 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 360102012937 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 360102012938 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 360102012939 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 360102012940 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 360102012941 FAD binding site [chemical binding]; other site 360102012942 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 360102012943 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 360102012944 FeS/SAM binding site; other site 360102012945 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 360102012946 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 360102012947 NADH(P)-binding; Region: NAD_binding_10; pfam13460 360102012948 NAD(P) binding site [chemical binding]; other site 360102012949 putative active site [active] 360102012950 Hemin uptake protein hemP; Region: hemP; pfam10636 360102012951 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 360102012952 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 360102012953 N-terminal plug; other site 360102012954 ligand-binding site [chemical binding]; other site 360102012955 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 360102012956 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 360102012957 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 360102012958 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 360102012959 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 360102012960 putative hemin binding site; other site 360102012961 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 360102012962 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102012963 ABC-ATPase subunit interface; other site 360102012964 dimer interface [polypeptide binding]; other site 360102012965 putative PBP binding regions; other site 360102012966 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 360102012967 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360102012968 Walker A/P-loop; other site 360102012969 ATP binding site [chemical binding]; other site 360102012970 Q-loop/lid; other site 360102012971 ABC transporter signature motif; other site 360102012972 Walker B; other site 360102012973 D-loop; other site 360102012974 H-loop/switch region; other site 360102012975 cystathionine beta-lyase; Provisional; Region: PRK09028 360102012976 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 360102012977 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102012978 catalytic residue [active] 360102012979 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 360102012980 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 360102012981 Transcriptional regulator [Transcription]; Region: LysR; COG0583 360102012982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102012983 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 360102012984 putative effector binding pocket; other site 360102012985 dimerization interface [polypeptide binding]; other site 360102012986 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 360102012987 CPxP motif; other site 360102012988 putative inner membrane protein; Provisional; Region: PRK11099 360102012989 Sulphur transport; Region: Sulf_transp; pfam04143 360102012990 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 360102012991 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 360102012992 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 360102012993 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 360102012994 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 360102012995 type III secretion system protein SsaQ; Validated; Region: PRK08035 360102012996 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 360102012997 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 360102012998 type III secretion system ATPase; Validated; Region: PRK06820 360102012999 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 360102013000 Walker A motif/ATP binding site; other site 360102013001 Walker B motif; other site 360102013002 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 360102013003 FHIPEP family; Region: FHIPEP; pfam00771 360102013004 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 360102013005 type III secretion system protein SsaK; Provisional; Region: PRK15354 360102013006 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 360102013007 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 360102013008 Type III secretion needle MxiH like; Region: MxiH; pfam09392 360102013009 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 360102013010 Type III secretion needle MxiH like; Region: MxiH; cl09641 360102013011 Helix-turn-helix domain; Region: HTH_18; pfam12833 360102013012 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102013013 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 360102013014 type III secretion system protein SsaD; Provisional; Region: PRK15367 360102013015 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 360102013016 outer membrane secretin SsaC; Provisional; Region: PRK15346 360102013017 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 360102013018 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 360102013019 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 360102013020 two component system sensor kinase SsrA; Provisional; Region: PRK15347 360102013021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 360102013022 dimer interface [polypeptide binding]; other site 360102013023 phosphorylation site [posttranslational modification] 360102013024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102013025 ATP binding site [chemical binding]; other site 360102013026 Mg2+ binding site [ion binding]; other site 360102013027 G-X-G motif; other site 360102013028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102013029 active site 360102013030 phosphorylation site [posttranslational modification] 360102013031 intermolecular recognition site; other site 360102013032 dimerization interface [polypeptide binding]; other site 360102013033 Hpt domain; Region: Hpt; pfam01627 360102013034 two component system sensor kinase SsrB; Provisional; Region: PRK15369 360102013035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102013036 active site 360102013037 phosphorylation site [posttranslational modification] 360102013038 intermolecular recognition site; other site 360102013039 dimerization interface [polypeptide binding]; other site 360102013040 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102013041 DNA binding residues [nucleotide binding] 360102013042 dimerization interface [polypeptide binding]; other site 360102013043 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 360102013044 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 360102013045 acetyl-CoA synthetase; Provisional; Region: PRK00174 360102013046 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 360102013047 active site 360102013048 CoA binding site [chemical binding]; other site 360102013049 acyl-activating enzyme (AAE) consensus motif; other site 360102013050 AMP binding site [chemical binding]; other site 360102013051 acetate binding site [chemical binding]; other site 360102013052 Predicted membrane protein [Function unknown]; Region: COG3162 360102013053 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 360102013054 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 360102013055 Na binding site [ion binding]; other site 360102013056 Abhydrolase family; Region: Abhydrolase_7; pfam12715 360102013057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102013058 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102013059 DNA-binding interface [nucleotide binding]; DNA binding site 360102013060 Integrase core domain; Region: rve; pfam00665 360102013061 transposase/IS protein; Provisional; Region: PRK09183 360102013062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102013063 Walker A motif; other site 360102013064 ATP binding site [chemical binding]; other site 360102013065 Walker B motif; other site 360102013066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102013067 H-loop/switch region; other site 360102013068 ABC transporter; Region: ABC_tran_2; pfam12848 360102013069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102013070 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 360102013071 Walker A/P-loop; other site 360102013072 ATP binding site [chemical binding]; other site 360102013073 Q-loop/lid; other site 360102013074 ABC transporter signature motif; other site 360102013075 putative outer membrane lipoprotein; Provisional; Region: PRK09967 360102013076 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 360102013077 ligand binding site [chemical binding]; other site 360102013078 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 360102013079 HAMP domain; Region: HAMP; pfam00672 360102013080 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 360102013081 metal binding site [ion binding]; metal-binding site 360102013082 active site 360102013083 I-site; other site 360102013084 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 360102013085 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 360102013086 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 360102013087 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 360102013088 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 360102013089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102013090 motif II; other site 360102013091 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 360102013092 lytic murein transglycosylase; Provisional; Region: PRK11619 360102013093 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 360102013094 N-acetyl-D-glucosamine binding site [chemical binding]; other site 360102013095 catalytic residue [active] 360102013096 Trp operon repressor; Provisional; Region: PRK01381 360102013097 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 360102013098 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 360102013099 catalytic core [active] 360102013100 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 360102013101 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102013102 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 360102013103 hypothetical protein; Provisional; Region: PRK10756 360102013104 CreA protein; Region: CreA; pfam05981 360102013105 two-component response regulator; Provisional; Region: PRK11173 360102013106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102013107 active site 360102013108 phosphorylation site [posttranslational modification] 360102013109 intermolecular recognition site; other site 360102013110 dimerization interface [polypeptide binding]; other site 360102013111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 360102013112 DNA binding site [nucleotide binding] 360102013113 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 360102013114 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 360102013115 putative catalytic residues [active] 360102013116 putative nucleotide binding site [chemical binding]; other site 360102013117 putative aspartate binding site [chemical binding]; other site 360102013118 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 360102013119 dimer interface [polypeptide binding]; other site 360102013120 putative threonine allosteric regulatory site; other site 360102013121 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 360102013122 putative threonine allosteric regulatory site; other site 360102013123 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 360102013124 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 360102013125 homoserine kinase; Provisional; Region: PRK01212 360102013126 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 360102013127 threonine synthase; Validated; Region: PRK09225 360102013128 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 360102013129 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 360102013130 catalytic residue [active] 360102013131 hypothetical protein; Validated; Region: PRK02101 360102013132 transaldolase-like protein; Provisional; Region: PTZ00411 360102013133 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 360102013134 active site 360102013135 dimer interface [polypeptide binding]; other site 360102013136 catalytic residue [active] 360102013137 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 360102013138 MPT binding site; other site 360102013139 trimer interface [polypeptide binding]; other site 360102013140 metabolite-proton symporter; Region: 2A0106; TIGR00883 360102013141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 360102013142 putative substrate translocation pore; other site 360102013143 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 360102013144 hypothetical protein; Provisional; Region: PRK10659 360102013145 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 360102013146 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 360102013147 nucleotide binding site [chemical binding]; other site 360102013148 chaperone protein DnaJ; Provisional; Region: PRK10767 360102013149 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 360102013150 HSP70 interaction site [polypeptide binding]; other site 360102013151 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 360102013152 substrate binding site [polypeptide binding]; other site 360102013153 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 360102013154 Zn binding sites [ion binding]; other site 360102013155 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 360102013156 dimer interface [polypeptide binding]; other site 360102013157 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 360102013158 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 360102013159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 360102013160 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 360102013161 putative dimerization interface [polypeptide binding]; other site 360102013162 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 360102013163 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 360102013164 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 360102013165 active site 360102013166 Riboflavin kinase; Region: Flavokinase; smart00904 360102013167 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 360102013168 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 360102013169 active site 360102013170 HIGH motif; other site 360102013171 nucleotide binding site [chemical binding]; other site 360102013172 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 360102013173 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 360102013174 active site 360102013175 KMSKS motif; other site 360102013176 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 360102013177 tRNA binding surface [nucleotide binding]; other site 360102013178 anticodon binding site; other site 360102013179 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 360102013180 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 360102013181 lipoprotein signal peptidase; Provisional; Region: PRK14787 360102013182 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 360102013183 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 360102013184 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 360102013185 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 360102013186 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102013187 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 360102013188 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 360102013189 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 360102013190 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 360102013191 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 360102013192 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 360102013193 catalytic site [active] 360102013194 subunit interface [polypeptide binding]; other site 360102013195 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 360102013196 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360102013197 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 360102013198 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 360102013199 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 360102013200 ATP-grasp domain; Region: ATP-grasp_4; cl17255 360102013201 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 360102013202 IMP binding site; other site 360102013203 dimer interface [polypeptide binding]; other site 360102013204 interdomain contacts; other site 360102013205 partial ornithine binding site; other site 360102013206 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 360102013207 Uncharacterized conserved protein [Function unknown]; Region: COG2966 360102013208 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 360102013209 hypothetical protein; Provisional; Region: PRK09917 360102013210 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 360102013211 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 360102013212 folate binding site [chemical binding]; other site 360102013213 NADP+ binding site [chemical binding]; other site 360102013214 Transposase IS200 like; Region: Y1_Tnp; pfam01797 360102013215 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 360102013216 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 360102013217 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 360102013218 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 360102013219 active site 360102013220 metal binding site [ion binding]; metal-binding site 360102013221 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 360102013222 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 360102013223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102013224 S-adenosylmethionine binding site [chemical binding]; other site 360102013225 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 360102013226 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 360102013227 SurA N-terminal domain; Region: SurA_N; pfam09312 360102013228 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 360102013229 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 360102013230 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 360102013231 OstA-like protein; Region: OstA; pfam03968 360102013232 Organic solvent tolerance protein; Region: OstA_C; pfam04453 360102013233 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 360102013234 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 360102013235 putative metal binding site [ion binding]; other site 360102013236 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 360102013237 HSP70 interaction site [polypeptide binding]; other site 360102013238 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 360102013239 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 360102013240 active site 360102013241 Uncharacterized conserved protein [Function unknown]; Region: COG5419 360102013242 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 360102013243 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 360102013244 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 360102013245 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 360102013246 Protein of unknown function (DUF877); Region: DUF877; pfam05943 360102013247 transposase/IS protein; Provisional; Region: PRK09183 360102013248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102013249 Walker A motif; other site 360102013250 ATP binding site [chemical binding]; other site 360102013251 Walker B motif; other site 360102013252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102013253 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102013254 DNA-binding interface [nucleotide binding]; DNA binding site 360102013255 Integrase core domain; Region: rve; pfam00665 360102013256 MASE1; Region: MASE1; pfam05231 360102013257 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 360102013258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 360102013259 active site 360102013260 phosphorylation site [posttranslational modification] 360102013261 intermolecular recognition site; other site 360102013262 dimerization interface [polypeptide binding]; other site 360102013263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 360102013264 DNA binding residues [nucleotide binding] 360102013265 dimerization interface [polypeptide binding]; other site 360102013266 phosphoethanolamine transferase; Provisional; Region: PRK11560 360102013267 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 360102013268 Sulfatase; Region: Sulfatase; pfam00884 360102013269 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 360102013270 putative proline-specific permease; Provisional; Region: proY; PRK10580 360102013271 Spore germination protein; Region: Spore_permease; cl17796 360102013272 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 360102013273 active sites [active] 360102013274 tetramer interface [polypeptide binding]; other site 360102013275 urocanate hydratase; Provisional; Region: PRK05414 360102013276 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 360102013277 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 360102013278 dimer interface [polypeptide binding]; other site 360102013279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 360102013280 catalytic residue [active] 360102013281 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 360102013282 active site 360102013283 hypothetical protein; Provisional; Region: PRK07206 360102013284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 360102013285 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 360102013286 DNA-binding interface [nucleotide binding]; DNA binding site 360102013287 Integrase core domain; Region: rve; pfam00665 360102013288 transposase/IS protein; Provisional; Region: PRK09183 360102013289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102013290 Walker A motif; other site 360102013291 ATP binding site [chemical binding]; other site 360102013292 Walker B motif; other site 360102013293 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 360102013294 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 360102013295 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 360102013296 putative ligand binding residues [chemical binding]; other site 360102013297 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 360102013298 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102013299 ABC-ATPase subunit interface; other site 360102013300 dimer interface [polypeptide binding]; other site 360102013301 putative PBP binding regions; other site 360102013302 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 360102013303 ABC-ATPase subunit interface; other site 360102013304 dimer interface [polypeptide binding]; other site 360102013305 putative PBP binding regions; other site 360102013306 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 360102013307 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 360102013308 Walker A/P-loop; other site 360102013309 ATP binding site [chemical binding]; other site 360102013310 Q-loop/lid; other site 360102013311 ABC transporter signature motif; other site 360102013312 Walker B; other site 360102013313 D-loop; other site 360102013314 H-loop/switch region; other site 360102013315 Virulence protein [General function prediction only]; Region: COG3943 360102013316 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 360102013317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 360102013318 non-specific DNA binding site [nucleotide binding]; other site 360102013319 salt bridge; other site 360102013320 sequence-specific DNA binding site [nucleotide binding]; other site 360102013321 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 360102013322 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 360102013323 integrase; Provisional; Region: PRK09692 360102013324 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 360102013325 active site 360102013326 Int/Topo IB signature motif; other site 360102013327 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 360102013328 putative dimerization interface [polypeptide binding]; other site 360102013329 Transcriptional regulators [Transcription]; Region: PurR; COG1609 360102013330 putative ligand binding site [chemical binding]; other site 360102013331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102013332 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 360102013333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 360102013334 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 360102013335 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 360102013336 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 360102013337 TM-ABC transporter signature motif; other site 360102013338 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 360102013339 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 360102013340 Walker A/P-loop; other site 360102013341 ATP binding site [chemical binding]; other site 360102013342 Q-loop/lid; other site 360102013343 ABC transporter signature motif; other site 360102013344 Walker B; other site 360102013345 D-loop; other site 360102013346 H-loop/switch region; other site 360102013347 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 360102013348 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 360102013349 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 360102013350 putative ligand binding site [chemical binding]; other site 360102013351 xylose isomerase; Provisional; Region: PRK05474 360102013352 xylose isomerase; Region: xylose_isom_A; TIGR02630 360102013353 xylulokinase; Provisional; Region: PRK15027 360102013354 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 360102013355 N- and C-terminal domain interface [polypeptide binding]; other site 360102013356 active site 360102013357 MgATP binding site [chemical binding]; other site 360102013358 catalytic site [active] 360102013359 metal binding site [ion binding]; metal-binding site 360102013360 xylulose binding site [chemical binding]; other site 360102013361 homodimer interface [polypeptide binding]; other site 360102013362 Fimbrial protein; Region: Fimbrial; pfam00419 360102013363 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 360102013364 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 360102013365 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 360102013366 PapC C-terminal domain; Region: PapC_C; pfam13953 360102013367 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102013368 PapC N-terminal domain; Region: PapC_N; pfam13954 360102013369 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 360102013370 Fimbrial protein; Region: Fimbrial; cl01416 360102013371 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 360102013372 Acyltransferase family; Region: Acyl_transf_3; pfam01757 360102013373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 360102013374 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102013375 Helix-turn-helix domain; Region: HTH_28; pfam13518 360102013376 putative transposase OrfB; Reviewed; Region: PHA02517 360102013377 HTH-like domain; Region: HTH_21; pfam13276 360102013378 Integrase core domain; Region: rve; pfam00665 360102013379 Integrase core domain; Region: rve_2; pfam13333 360102013380 sugar phosphate phosphatase; Provisional; Region: PRK10513 360102013381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102013382 active site 360102013383 motif I; other site 360102013384 motif II; other site 360102013385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102013386 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 360102013387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 360102013388 Mg2+ binding site [ion binding]; other site 360102013389 G-X-G motif; other site 360102013390 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 360102013391 anchoring element; other site 360102013392 dimer interface [polypeptide binding]; other site 360102013393 ATP binding site [chemical binding]; other site 360102013394 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 360102013395 active site 360102013396 putative metal-binding site [ion binding]; other site 360102013397 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 360102013398 recF protein; Region: recf; TIGR00611 360102013399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102013400 Walker A/P-loop; other site 360102013401 ATP binding site [chemical binding]; other site 360102013402 Q-loop/lid; other site 360102013403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 360102013404 ABC transporter signature motif; other site 360102013405 Walker B; other site 360102013406 D-loop; other site 360102013407 H-loop/switch region; other site 360102013408 DNA polymerase III subunit beta; Validated; Region: PRK05643 360102013409 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 360102013410 putative DNA binding surface [nucleotide binding]; other site 360102013411 dimer interface [polypeptide binding]; other site 360102013412 beta-clamp/clamp loader binding surface; other site 360102013413 beta-clamp/translesion DNA polymerase binding surface; other site 360102013414 DnaA N-terminal domain; Region: DnaA_N; pfam11638 360102013415 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 360102013416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 360102013417 Walker A motif; other site 360102013418 ATP binding site [chemical binding]; other site 360102013419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 360102013420 Walker B motif; other site 360102013421 arginine finger; other site 360102013422 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 360102013423 DnaA box-binding interface [nucleotide binding]; other site 360102013424 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 360102013425 ribonuclease P; Reviewed; Region: rnpA; PRK01732 360102013426 hypothetical protein; Validated; Region: PRK00041 360102013427 membrane protein insertase; Provisional; Region: PRK01318 360102013428 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 360102013429 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 360102013430 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 360102013431 trmE is a tRNA modification GTPase; Region: trmE; cd04164 360102013432 G1 box; other site 360102013433 GTP/Mg2+ binding site [chemical binding]; other site 360102013434 Switch I region; other site 360102013435 G2 box; other site 360102013436 Switch II region; other site 360102013437 G3 box; other site 360102013438 G4 box; other site 360102013439 G5 box; other site 360102013440 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 360102013441 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 360102013442 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 360102013443 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 360102013444 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 360102013445 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 360102013446 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 360102013447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 360102013448 motif II; other site 360102013449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102013450 dimer interface [polypeptide binding]; other site 360102013451 conserved gate region; other site 360102013452 putative PBP binding loops; other site 360102013453 ABC-ATPase subunit interface; other site 360102013454 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 360102013455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102013456 dimer interface [polypeptide binding]; other site 360102013457 conserved gate region; other site 360102013458 putative PBP binding loops; other site 360102013459 ABC-ATPase subunit interface; other site 360102013460 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 360102013461 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102013462 substrate binding pocket [chemical binding]; other site 360102013463 membrane-bound complex binding site; other site 360102013464 hinge residues; other site 360102013465 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 360102013466 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 360102013467 transcriptional regulator PhoU; Provisional; Region: PRK11115 360102013468 PhoU domain; Region: PhoU; pfam01895 360102013469 PhoU domain; Region: PhoU; pfam01895 360102013470 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 360102013471 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 360102013472 Walker A/P-loop; other site 360102013473 ATP binding site [chemical binding]; other site 360102013474 Q-loop/lid; other site 360102013475 ABC transporter signature motif; other site 360102013476 Walker B; other site 360102013477 D-loop; other site 360102013478 H-loop/switch region; other site 360102013479 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 360102013480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102013481 dimer interface [polypeptide binding]; other site 360102013482 conserved gate region; other site 360102013483 putative PBP binding loops; other site 360102013484 ABC-ATPase subunit interface; other site 360102013485 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 360102013486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 360102013487 dimer interface [polypeptide binding]; other site 360102013488 conserved gate region; other site 360102013489 putative PBP binding loops; other site 360102013490 ABC-ATPase subunit interface; other site 360102013491 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 360102013492 substrate binding pocket [chemical binding]; other site 360102013493 membrane-bound complex binding site; other site 360102013494 hinge residues; other site 360102013495 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 360102013496 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 360102013497 glutaminase active site [active] 360102013498 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 360102013499 dimer interface [polypeptide binding]; other site 360102013500 active site 360102013501 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 360102013502 dimer interface [polypeptide binding]; other site 360102013503 active site 360102013504 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 360102013505 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 360102013506 Substrate binding site; other site 360102013507 Mg++ binding site; other site 360102013508 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 360102013509 active site 360102013510 substrate binding site [chemical binding]; other site 360102013511 CoA binding site [chemical binding]; other site 360102013512 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 360102013513 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 360102013514 gamma subunit interface [polypeptide binding]; other site 360102013515 epsilon subunit interface [polypeptide binding]; other site 360102013516 LBP interface [polypeptide binding]; other site 360102013517 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 360102013518 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 360102013519 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 360102013520 alpha subunit interaction interface [polypeptide binding]; other site 360102013521 Walker A motif; other site 360102013522 ATP binding site [chemical binding]; other site 360102013523 Walker B motif; other site 360102013524 inhibitor binding site; inhibition site 360102013525 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 360102013526 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 360102013527 core domain interface [polypeptide binding]; other site 360102013528 delta subunit interface [polypeptide binding]; other site 360102013529 epsilon subunit interface [polypeptide binding]; other site 360102013530 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 360102013531 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 360102013532 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 360102013533 beta subunit interaction interface [polypeptide binding]; other site 360102013534 Walker A motif; other site 360102013535 ATP binding site [chemical binding]; other site 360102013536 Walker B motif; other site 360102013537 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 360102013538 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 360102013539 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 360102013540 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 360102013541 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 360102013542 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 360102013543 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 360102013544 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 360102013545 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 360102013546 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 360102013547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 360102013548 S-adenosylmethionine binding site [chemical binding]; other site 360102013549 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 360102013550 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 360102013551 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932