-- dump date 20140620_141121 -- class Genbank::misc_feature -- table misc_feature_note -- id note 637382000001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382000002 Integrase core domain; Region: rve; pfam00665 637382000003 Integrase core domain; Region: rve_3; cl15866 637382000004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 637382000005 Integrase core domain; Region: rve; pfam00665 637382000006 Integrase core domain; Region: rve_3; pfam13683 637382000007 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 637382000008 YopE, N terminal; Region: YopE_N; pfam09020 637382000009 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 637382000010 switch II binding region; other site 637382000011 Rac1 P-loop interaction site [polypeptide binding]; other site 637382000012 GTP binding residues [chemical binding]; other site 637382000013 switch I binding region; other site 637382000014 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 637382000015 plasmid-partitioning protein; Provisional; Region: PRK13698 637382000016 ParB-like nuclease domain; Region: ParB; smart00470 637382000017 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 637382000018 MerR family regulatory protein; Region: MerR; pfam00376 637382000019 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 637382000020 P-loop; other site 637382000021 Magnesium ion binding site [ion binding]; other site 637382000022 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 637382000023 Magnesium ion binding site [ion binding]; other site 637382000024 HTH-like domain; Region: HTH_21; pfam13276 637382000025 Integrase core domain; Region: rve; pfam00665 637382000026 Transposase; Region: HTH_Tnp_1; pfam01527 637382000027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637382000028 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 637382000029 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; pfam03543 637382000030 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 637382000031 hypothetical protein; Provisional; Region: PRK11622 637382000032 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 637382000033 Integrase core domain; Region: rve; pfam00665 637382000034 YopD protein; Region: YopD; pfam05844 637382000035 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 637382000036 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 637382000037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637382000038 binding surface 637382000039 TPR motif; other site 637382000040 V antigen (LcrV) protein; Region: LcrV; pfam04792 637382000041 Type III secretion system regulator (LcrR); Region: LcrR; cl09838 637382000042 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 637382000043 FHIPEP family; Region: FHIPEP; pfam00771 637382000044 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 637382000045 type III secretion protein, YscX family; Region: type_III_YscX; TIGR02502 637382000046 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 637382000047 HrpJ-like domain; Region: HrpJ; cl15454 637382000048 type III secretion system ATPase; Provisional; Region: PRK06936 637382000049 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637382000050 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 637382000051 Walker A motif/ATP binding site; other site 637382000052 Walker B motif; other site 637382000053 Type III secretion protein YscO; Region: YscO; pfam07321 637382000054 type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514 637382000055 type III secretion system protein; Validated; Region: PRK06933 637382000056 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 637382000057 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 637382000058 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 637382000059 Type III secretory pathway, component EscU [Intracellular trafficking and secretion]; Region: EscU; COG4792 637382000060 type III secretion system chaperone YscW; Region: YscW; TIGR02567 637382000061 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637382000062 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 637382000063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382000064 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382000065 type III secretion system chaperone, YscB family; Region: type_III_yscB; TIGR02513 637382000066 potential frameshift: common BLAST hit: gi|294496845|ref|YP_003560542.1| type III secretion outer membrane pore YscC 637382000067 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 637382000068 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 637382000069 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 637382000070 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 637382000071 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 637382000072 type III secretion system protein SsaD; Provisional; Region: PRK15367 637382000073 type III secretion protein, YscG family; Region: type_III_yscG; TIGR02508 637382000074 type III secretion effector, YopR family; Region: type_III_yopR; TIGR02509 637382000075 type III secretion apparatus protein, YscI/HrpB, C-terminal domain; Region: yscI_hrpB_dom; TIGR02497 637382000076 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 637382000077 YOP proteins translocation protein K (YscK); Region: YscK; pfam06578 637382000078 type III secretion system protein; Reviewed; Region: PRK06937 637382000079 Flagellar assembly protein FliH; Region: FliH; pfam02108 637382000080 YopH, N-terminal; Region: YopH_N; pfam09013 637382000081 YopH, N-terminal; Region: YopH_N; pfam09013 637382000082 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 637382000083 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 637382000084 active site 637382000085 Integrase core domain; Region: rve; pfam00665 637382000086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 637382000087 Integrase core domain; Region: rve_3; pfam13683 637382000088 effector protein YopJ; Provisional; Region: PRK15371 637382000089 Protein kinase domain; Region: Pkinase; pfam00069 637382000090 Catalytic domain of Protein Kinases; Region: PKc; cd00180 637382000091 active site 637382000092 ATP binding site [chemical binding]; other site 637382000093 substrate binding site [chemical binding]; other site 637382000094 activation loop (A-loop); other site 637382000095 Rac1-binding domain; Region: Rac1; pfam09632 637382000096 replication protein; Provisional; Region: PRK13750 637382000097 HTH-like domain; Region: HTH_21; pfam13276 637382000098 Integrase core domain; Region: rve; pfam00665 637382000099 Transposase; Region: HTH_Tnp_1; pfam01527 637382000100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637382000101 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 637382000102 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 637382000103 trimer interface [polypeptide binding]; other site 637382000104 Haemagglutinin; Region: HIM; pfam05662 637382000105 YadA-like C-terminal region; Region: YadA; pfam03895 637382000106 HTH-like domain; Region: HTH_21; pfam13276 637382000107 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 637382000108 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 637382000109 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637382000110 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 637382000111 catalytic residues [active] 637382000112 catalytic nucleophile [active] 637382000113 Presynaptic Site I dimer interface [polypeptide binding]; other site 637382000114 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 637382000115 Synaptic Flat tetramer interface [polypeptide binding]; other site 637382000116 Synaptic Site I dimer interface [polypeptide binding]; other site 637382000117 DNA binding site [nucleotide binding] 637382000118 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382000119 DNA-binding interface [nucleotide binding]; DNA binding site 637382000120 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 637382000121 HTH-like domain; Region: HTH_21; pfam13276 637382000122 Integrase core domain; Region: rve; pfam00665 637382000123 Integrase core domain; Region: rve_3; pfam13683 637382000124 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 637382000125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382000126 Walker A motif; other site 637382000127 ATP binding site [chemical binding]; other site 637382000128 FMN-binding protein MioC; Provisional; Region: PRK09004 637382000129 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 637382000130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637382000131 putative DNA binding site [nucleotide binding]; other site 637382000132 putative Zn2+ binding site [ion binding]; other site 637382000133 AsnC family; Region: AsnC_trans_reg; pfam01037 637382000134 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 637382000135 motif 1; other site 637382000136 dimer interface [polypeptide binding]; other site 637382000137 active site 637382000138 motif 2; other site 637382000139 motif 3; other site 637382000140 hypothetical protein; Provisional; Region: yieM; PRK10997 637382000141 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 637382000142 metal ion-dependent adhesion site (MIDAS); other site 637382000143 regulatory ATPase RavA; Provisional; Region: PRK13531 637382000144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382000145 Walker A motif; other site 637382000146 ATP binding site [chemical binding]; other site 637382000147 Walker B motif; other site 637382000148 arginine finger; other site 637382000149 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 637382000150 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 637382000151 potassium uptake protein; Region: kup; TIGR00794 637382000152 D-ribose pyranase; Provisional; Region: PRK11797 637382000153 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637382000154 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 637382000155 substrate binding site [chemical binding]; other site 637382000156 dimer interface [polypeptide binding]; other site 637382000157 ATP binding site [chemical binding]; other site 637382000158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382000159 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637382000160 putative substrate translocation pore; other site 637382000161 Transcriptional regulators [Transcription]; Region: FadR; COG2186 637382000162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637382000163 DNA-binding site [nucleotide binding]; DNA binding site 637382000164 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 637382000165 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382000166 MULE transposase domain; Region: MULE; pfam10551 637382000167 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 637382000168 Walker A motif; other site 637382000169 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 637382000170 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 637382000171 GTP binding site; other site 637382000172 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 637382000173 serine/threonine protein kinase; Provisional; Region: PRK11768 637382000174 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 637382000175 hinge region; other site 637382000176 alpha helical domain; other site 637382000177 DNA polymerase I; Provisional; Region: PRK05755 637382000178 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 637382000179 active site 637382000180 metal binding site 1 [ion binding]; metal-binding site 637382000181 putative 5' ssDNA interaction site; other site 637382000182 metal binding site 3; metal-binding site 637382000183 metal binding site 2 [ion binding]; metal-binding site 637382000184 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 637382000185 putative DNA binding site [nucleotide binding]; other site 637382000186 putative metal binding site [ion binding]; other site 637382000187 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 637382000188 active site 637382000189 catalytic site [active] 637382000190 substrate binding site [chemical binding]; other site 637382000191 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 637382000192 active site 637382000193 DNA binding site [nucleotide binding] 637382000194 catalytic site [active] 637382000195 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382000196 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 637382000197 G1 box; other site 637382000198 GTP/Mg2+ binding site [chemical binding]; other site 637382000199 Switch I region; other site 637382000200 G2 box; other site 637382000201 G3 box; other site 637382000202 Switch II region; other site 637382000203 G4 box; other site 637382000204 G5 box; other site 637382000205 Der GTPase activator; Provisional; Region: PRK05244 637382000206 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 637382000207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382000208 FeS/SAM binding site; other site 637382000209 HemN C-terminal domain; Region: HemN_C; pfam06969 637382000210 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 637382000211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382000212 active site 637382000213 phosphorylation site [posttranslational modification] 637382000214 intermolecular recognition site; other site 637382000215 dimerization interface [polypeptide binding]; other site 637382000216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382000217 Walker A motif; other site 637382000218 ATP binding site [chemical binding]; other site 637382000219 Walker B motif; other site 637382000220 arginine finger; other site 637382000221 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 637382000222 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 637382000223 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 637382000224 dimer interface [polypeptide binding]; other site 637382000225 phosphorylation site [posttranslational modification] 637382000226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382000227 ATP binding site [chemical binding]; other site 637382000228 Mg2+ binding site [ion binding]; other site 637382000229 G-X-G motif; other site 637382000230 glutamine synthetase; Provisional; Region: glnA; PRK09469 637382000231 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 637382000232 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 637382000233 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 637382000234 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 637382000235 G1 box; other site 637382000236 putative GEF interaction site [polypeptide binding]; other site 637382000237 GTP/Mg2+ binding site [chemical binding]; other site 637382000238 Switch I region; other site 637382000239 G2 box; other site 637382000240 G3 box; other site 637382000241 Switch II region; other site 637382000242 G4 box; other site 637382000243 G5 box; other site 637382000244 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 637382000245 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 637382000246 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 637382000247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382000248 motif II; other site 637382000249 hypothetical protein; Reviewed; Region: PRK01637 637382000250 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 637382000251 putative active site [active] 637382000252 dimerization interface [polypeptide binding]; other site 637382000253 putative tRNAtyr binding site [nucleotide binding]; other site 637382000254 transposase/IS protein; Provisional; Region: PRK09183 637382000255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382000256 Walker A motif; other site 637382000257 ATP binding site [chemical binding]; other site 637382000258 Walker B motif; other site 637382000259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382000260 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382000261 DNA-binding interface [nucleotide binding]; DNA binding site 637382000262 Integrase core domain; Region: rve; pfam00665 637382000263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637382000264 Coenzyme A binding pocket [chemical binding]; other site 637382000265 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 637382000266 AsmA family; Region: AsmA; pfam05170 637382000267 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 637382000268 potential frameshift: common BLAST hit: gi|294502142|ref|YP_003566204.1| putative membrane permease 637382000269 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 637382000270 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 637382000271 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 637382000272 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 637382000273 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 637382000274 generic binding surface II; other site 637382000275 ssDNA binding site; other site 637382000276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637382000277 ATP binding site [chemical binding]; other site 637382000278 putative Mg++ binding site [ion binding]; other site 637382000279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382000280 nucleotide binding region [chemical binding]; other site 637382000281 ATP-binding site [chemical binding]; other site 637382000282 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 637382000283 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 637382000284 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 637382000285 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 637382000286 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637382000287 Zn2+ binding site [ion binding]; other site 637382000288 Mg2+ binding site [ion binding]; other site 637382000289 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637382000290 synthetase active site [active] 637382000291 NTP binding site [chemical binding]; other site 637382000292 metal binding site [ion binding]; metal-binding site 637382000293 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 637382000294 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 637382000295 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 637382000296 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 637382000297 catalytic site [active] 637382000298 G-X2-G-X-G-K; other site 637382000299 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 637382000300 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 637382000301 nucleotide binding pocket [chemical binding]; other site 637382000302 K-X-D-G motif; other site 637382000303 catalytic site [active] 637382000304 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 637382000305 Predicted membrane protein [Function unknown]; Region: COG2860 637382000306 UPF0126 domain; Region: UPF0126; pfam03458 637382000307 UPF0126 domain; Region: UPF0126; pfam03458 637382000308 hypothetical protein; Provisional; Region: PRK11820 637382000309 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 637382000310 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 637382000311 ribonuclease PH; Reviewed; Region: rph; PRK00173 637382000312 Ribonuclease PH; Region: RNase_PH_bact; cd11362 637382000313 hexamer interface [polypeptide binding]; other site 637382000314 active site 637382000315 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637382000316 active site 637382000317 division inhibitor protein; Provisional; Region: slmA; PRK09480 637382000318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637382000319 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 637382000320 trimer interface [polypeptide binding]; other site 637382000321 active site 637382000322 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 637382000323 Flavoprotein; Region: Flavoprotein; pfam02441 637382000324 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 637382000325 hypothetical protein; Reviewed; Region: PRK00024 637382000326 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 637382000327 MPN+ (JAMM) motif; other site 637382000328 Zinc-binding site [ion binding]; other site 637382000329 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 637382000330 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 637382000331 DNA binding site [nucleotide binding] 637382000332 catalytic residue [active] 637382000333 H2TH interface [polypeptide binding]; other site 637382000334 putative catalytic residues [active] 637382000335 turnover-facilitating residue; other site 637382000336 intercalation triad [nucleotide binding]; other site 637382000337 8OG recognition residue [nucleotide binding]; other site 637382000338 putative reading head residues; other site 637382000339 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 637382000340 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 637382000341 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 637382000342 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 637382000343 active site 637382000344 (T/H)XGH motif; other site 637382000345 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 637382000346 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 637382000347 putative metal binding site; other site 637382000348 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 637382000349 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 637382000350 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637382000351 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 637382000352 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 637382000353 putative active site [active] 637382000354 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 637382000355 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 637382000356 putative active site [active] 637382000357 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 637382000358 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 637382000359 NADP binding site [chemical binding]; other site 637382000360 homopentamer interface [polypeptide binding]; other site 637382000361 substrate binding site [chemical binding]; other site 637382000362 active site 637382000363 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 637382000364 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 637382000365 substrate-cofactor binding pocket; other site 637382000366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382000367 catalytic residue [active] 637382000368 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 637382000369 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 637382000370 NAD(P) binding site [chemical binding]; other site 637382000371 Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl17042 637382000372 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 637382000373 NodB motif; other site 637382000374 putative active site [active] 637382000375 Zn binding site [ion binding]; other site 637382000376 AmiB activator; Provisional; Region: PRK11637 637382000377 Peptidase family M23; Region: Peptidase_M23; pfam01551 637382000378 phosphoglyceromutase; Provisional; Region: PRK05434 637382000379 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 637382000380 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637382000381 active site residue [active] 637382000382 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 637382000383 SecA binding site; other site 637382000384 Preprotein binding site; other site 637382000385 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 637382000386 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 637382000387 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 637382000388 serine acetyltransferase; Provisional; Region: cysE; PRK11132 637382000389 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 637382000390 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 637382000391 trimer interface [polypeptide binding]; other site 637382000392 active site 637382000393 substrate binding site [chemical binding]; other site 637382000394 CoA binding site [chemical binding]; other site 637382000395 putative rRNA methylase; Provisional; Region: PRK10358 637382000396 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 637382000397 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 637382000398 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382000399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382000400 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 637382000401 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637382000402 DNA binding site [nucleotide binding] 637382000403 active site 637382000404 two-component sensor protein; Provisional; Region: cpxA; PRK09470 637382000405 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 637382000406 dimerization interface [polypeptide binding]; other site 637382000407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382000408 dimer interface [polypeptide binding]; other site 637382000409 phosphorylation site [posttranslational modification] 637382000410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382000411 ATP binding site [chemical binding]; other site 637382000412 Mg2+ binding site [ion binding]; other site 637382000413 G-X-G motif; other site 637382000414 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 637382000415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382000416 active site 637382000417 phosphorylation site [posttranslational modification] 637382000418 intermolecular recognition site; other site 637382000419 dimerization interface [polypeptide binding]; other site 637382000420 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382000421 DNA binding site [nucleotide binding] 637382000422 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 637382000423 dimer interface [polypeptide binding]; other site 637382000424 Uncharacterized conserved protein [Function unknown]; Region: COG5464 637382000425 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 637382000426 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 637382000427 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 637382000428 6-phosphofructokinase; Provisional; Region: PRK03202 637382000429 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 637382000430 active site 637382000431 ADP/pyrophosphate binding site [chemical binding]; other site 637382000432 dimerization interface [polypeptide binding]; other site 637382000433 allosteric effector site; other site 637382000434 fructose-1,6-bisphosphate binding site; other site 637382000435 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382000436 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 637382000437 substrate binding pocket [chemical binding]; other site 637382000438 membrane-bound complex binding site; other site 637382000439 hinge residues; other site 637382000440 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 637382000441 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 637382000442 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 637382000443 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 637382000444 transmembrane helices; other site 637382000445 hypothetical protein; Validated; Region: PRK06201 637382000446 hypothetical protein; Provisional; Region: PRK09262 637382000447 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 637382000448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382000449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382000450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382000451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382000452 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637382000453 dimerization interface [polypeptide binding]; other site 637382000454 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 637382000455 triosephosphate isomerase; Provisional; Region: PRK14567 637382000456 substrate binding site [chemical binding]; other site 637382000457 dimer interface [polypeptide binding]; other site 637382000458 catalytic triad [active] 637382000459 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 637382000460 Predicted membrane protein [Function unknown]; Region: COG3152 637382000461 ferredoxin-NADP reductase; Provisional; Region: PRK10926 637382000462 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 637382000463 FAD binding pocket [chemical binding]; other site 637382000464 FAD binding motif [chemical binding]; other site 637382000465 phosphate binding motif [ion binding]; other site 637382000466 beta-alpha-beta structure motif; other site 637382000467 NAD binding pocket [chemical binding]; other site 637382000468 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 637382000469 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 637382000470 putative active site [active] 637382000471 glycerol kinase; Provisional; Region: glpK; PRK00047 637382000472 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 637382000473 N- and C-terminal domain interface [polypeptide binding]; other site 637382000474 active site 637382000475 MgATP binding site [chemical binding]; other site 637382000476 catalytic site [active] 637382000477 metal binding site [ion binding]; metal-binding site 637382000478 glycerol binding site [chemical binding]; other site 637382000479 homotetramer interface [polypeptide binding]; other site 637382000480 homodimer interface [polypeptide binding]; other site 637382000481 FBP binding site [chemical binding]; other site 637382000482 protein IIAGlc interface [polypeptide binding]; other site 637382000483 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 637382000484 amphipathic channel; other site 637382000485 Asn-Pro-Ala signature motifs; other site 637382000486 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382000487 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 637382000488 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 637382000489 putative active site [active] 637382000490 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637382000491 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 637382000492 Walker A/P-loop; other site 637382000493 ATP binding site [chemical binding]; other site 637382000494 Q-loop/lid; other site 637382000495 ABC transporter signature motif; other site 637382000496 Walker B; other site 637382000497 D-loop; other site 637382000498 H-loop/switch region; other site 637382000499 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 637382000500 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382000501 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382000502 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 637382000503 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 637382000504 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 637382000505 UbiA prenyltransferase family; Region: UbiA; pfam01040 637382000506 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 637382000507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382000508 Walker A motif; other site 637382000509 ATP binding site [chemical binding]; other site 637382000510 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 637382000511 Walker B motif; other site 637382000512 arginine finger; other site 637382000513 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637382000514 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 637382000515 active site 637382000516 HslU subunit interaction site [polypeptide binding]; other site 637382000517 Sporulation related domain; Region: SPOR; cl10051 637382000518 cell division protein FtsN; Provisional; Region: PRK12757 637382000519 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382000520 DNA binding site [nucleotide binding] 637382000521 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 637382000522 domain linker motif; other site 637382000523 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 637382000524 dimerization interface [polypeptide binding]; other site 637382000525 ligand binding site [chemical binding]; other site 637382000526 primosome assembly protein PriA; Validated; Region: PRK05580 637382000527 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637382000528 ATP binding site [chemical binding]; other site 637382000529 putative Mg++ binding site [ion binding]; other site 637382000530 helicase superfamily c-terminal domain; Region: HELICc; smart00490 637382000531 ATP-binding site [chemical binding]; other site 637382000532 Predicted membrane protein [Function unknown]; Region: COG4682 637382000533 yiaA/B two helix domain; Region: YiaAB; pfam05360 637382000534 yiaA/B two helix domain; Region: YiaAB; pfam05360 637382000535 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 637382000536 dimerization interface [polypeptide binding]; other site 637382000537 DNA binding site [nucleotide binding] 637382000538 corepressor binding sites; other site 637382000539 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637382000540 homodimer interface [polypeptide binding]; other site 637382000541 substrate-cofactor binding pocket; other site 637382000542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382000543 catalytic residue [active] 637382000544 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 637382000545 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 637382000546 putative catalytic residues [active] 637382000547 putative nucleotide binding site [chemical binding]; other site 637382000548 putative aspartate binding site [chemical binding]; other site 637382000549 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 637382000550 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 637382000551 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 637382000552 FAD binding site [chemical binding]; other site 637382000553 putative transposase OrfB; Reviewed; Region: PHA02517 637382000554 HTH-like domain; Region: HTH_21; pfam13276 637382000555 Integrase core domain; Region: rve; pfam00665 637382000556 Integrase core domain; Region: rve_2; pfam13333 637382000557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637382000558 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382000559 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382000560 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 637382000561 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 637382000562 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637382000563 intramembrane serine protease GlpG; Provisional; Region: PRK10907 637382000564 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 637382000565 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 637382000566 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 637382000567 active site residue [active] 637382000568 transcriptional regulator MalT; Provisional; Region: PRK04841 637382000569 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382000570 DNA binding residues [nucleotide binding] 637382000571 dimerization interface [polypeptide binding]; other site 637382000572 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637382000573 maltodextrin phosphorylase; Provisional; Region: PRK14985 637382000574 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 637382000575 active site pocket [active] 637382000576 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 637382000577 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 637382000578 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 637382000579 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 637382000580 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 637382000581 DNA utilization protein GntX; Provisional; Region: PRK11595 637382000582 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637382000583 active site 637382000584 carboxylesterase BioH; Provisional; Region: PRK10349 637382000585 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 637382000586 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 637382000587 G1 box; other site 637382000588 GTP/Mg2+ binding site [chemical binding]; other site 637382000589 Switch I region; other site 637382000590 G2 box; other site 637382000591 G3 box; other site 637382000592 Switch II region; other site 637382000593 G4 box; other site 637382000594 G5 box; other site 637382000595 Nucleoside recognition; Region: Gate; pfam07670 637382000596 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 637382000597 Nucleoside recognition; Region: Gate; pfam07670 637382000598 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 637382000599 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 637382000600 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 637382000601 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 637382000602 RNA binding site [nucleotide binding]; other site 637382000603 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 637382000604 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 637382000605 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 637382000606 osmolarity response regulator; Provisional; Region: ompR; PRK09468 637382000607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382000608 active site 637382000609 phosphorylation site [posttranslational modification] 637382000610 intermolecular recognition site; other site 637382000611 dimerization interface [polypeptide binding]; other site 637382000612 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382000613 DNA binding site [nucleotide binding] 637382000614 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 637382000615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382000616 dimerization interface [polypeptide binding]; other site 637382000617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382000618 dimer interface [polypeptide binding]; other site 637382000619 phosphorylation site [posttranslational modification] 637382000620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382000621 ATP binding site [chemical binding]; other site 637382000622 Mg2+ binding site [ion binding]; other site 637382000623 G-X-G motif; other site 637382000624 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 637382000625 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 637382000626 active site 637382000627 substrate-binding site [chemical binding]; other site 637382000628 metal-binding site [ion binding] 637382000629 ATP binding site [chemical binding]; other site 637382000630 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 637382000631 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 637382000632 dimerization interface [polypeptide binding]; other site 637382000633 domain crossover interface; other site 637382000634 redox-dependent activation switch; other site 637382000635 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637382000636 RNA binding surface [nucleotide binding]; other site 637382000637 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 637382000638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382000639 motif II; other site 637382000640 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 637382000641 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 637382000642 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 637382000643 ADP-ribose binding site [chemical binding]; other site 637382000644 dimer interface [polypeptide binding]; other site 637382000645 active site 637382000646 nudix motif; other site 637382000647 metal binding site [ion binding]; metal-binding site 637382000648 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 637382000649 Transglycosylase; Region: Transgly; pfam00912 637382000650 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 637382000651 Competence protein A; Region: Competence_A; pfam11104 637382000652 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 637382000653 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 637382000654 potential frameshift: common BLAST hit: gi|153947341|ref|YP_001402915.1| outer membrane porin HofQ 637382000655 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 637382000656 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 637382000657 shikimate kinase; Reviewed; Region: aroK; PRK00131 637382000658 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 637382000659 ADP binding site [chemical binding]; other site 637382000660 magnesium binding site [ion binding]; other site 637382000661 putative shikimate binding site; other site 637382000662 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 637382000663 active site 637382000664 dimer interface [polypeptide binding]; other site 637382000665 metal binding site [ion binding]; metal-binding site 637382000666 hypothetical protein; Reviewed; Region: PRK11901 637382000667 cell division protein DamX; Validated; Region: PRK10905 637382000668 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 637382000669 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 637382000670 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 637382000671 substrate binding site [chemical binding]; other site 637382000672 hexamer interface [polypeptide binding]; other site 637382000673 metal binding site [ion binding]; metal-binding site 637382000674 phosphoglycolate phosphatase; Provisional; Region: PRK13222 637382000675 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637382000676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382000677 motif II; other site 637382000678 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 637382000679 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 637382000680 active site 637382000681 HIGH motif; other site 637382000682 dimer interface [polypeptide binding]; other site 637382000683 KMSKS motif; other site 637382000684 siroheme synthase; Provisional; Region: cysG; PRK10637 637382000685 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 637382000686 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 637382000687 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 637382000688 active site 637382000689 SAM binding site [chemical binding]; other site 637382000690 homodimer interface [polypeptide binding]; other site 637382000691 nitrite transporter NirC; Provisional; Region: PRK11562 637382000692 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 637382000693 nitrite reductase subunit NirD; Provisional; Region: PRK14989 637382000694 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637382000695 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 637382000696 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 637382000697 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 637382000698 cytosine deaminase; Provisional; Region: PRK09230 637382000699 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 637382000700 active site 637382000701 putative transporter; Provisional; Region: PRK03699 637382000702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382000703 putative substrate translocation pore; other site 637382000704 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 637382000705 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637382000706 N-terminal plug; other site 637382000707 ligand-binding site [chemical binding]; other site 637382000708 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637382000709 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382000710 DNA binding site [nucleotide binding] 637382000711 domain linker motif; other site 637382000712 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 637382000713 dimerization interface (closed form) [polypeptide binding]; other site 637382000714 ligand binding site [chemical binding]; other site 637382000715 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 637382000716 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 637382000717 NAD binding site [chemical binding]; other site 637382000718 sugar binding site [chemical binding]; other site 637382000719 divalent metal binding site [ion binding]; other site 637382000720 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637382000721 dimer interface [polypeptide binding]; other site 637382000722 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 637382000723 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 637382000724 substrate binding site [chemical binding]; other site 637382000725 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 637382000726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 637382000727 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 637382000728 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 637382000729 glutamine binding [chemical binding]; other site 637382000730 catalytic triad [active] 637382000731 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 637382000732 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637382000733 inhibitor-cofactor binding pocket; inhibition site 637382000734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382000735 catalytic residue [active] 637382000736 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 637382000737 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 637382000738 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 637382000739 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 637382000740 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637382000741 ligand binding site [chemical binding]; other site 637382000742 flexible hinge region; other site 637382000743 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 637382000744 putative switch regulator; other site 637382000745 non-specific DNA interactions [nucleotide binding]; other site 637382000746 DNA binding site [nucleotide binding] 637382000747 sequence specific DNA binding site [nucleotide binding]; other site 637382000748 putative cAMP binding site [chemical binding]; other site 637382000749 hypothetical protein; Provisional; Region: PRK10738 637382000750 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 637382000751 phosphoribulokinase; Provisional; Region: PRK15453 637382000752 active site 637382000753 putative hydrolase; Provisional; Region: PRK10985 637382000754 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 637382000755 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 637382000756 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382000757 substrate binding pocket [chemical binding]; other site 637382000758 membrane-bound complex binding site; other site 637382000759 hinge residues; other site 637382000760 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 637382000761 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 637382000762 Walker A/P-loop; other site 637382000763 ATP binding site [chemical binding]; other site 637382000764 Q-loop/lid; other site 637382000765 ABC transporter signature motif; other site 637382000766 Walker B; other site 637382000767 D-loop; other site 637382000768 H-loop/switch region; other site 637382000769 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637382000770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382000771 dimer interface [polypeptide binding]; other site 637382000772 conserved gate region; other site 637382000773 putative PBP binding loops; other site 637382000774 ABC-ATPase subunit interface; other site 637382000775 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 637382000776 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 637382000777 active site 637382000778 iron coordination sites [ion binding]; other site 637382000779 substrate binding pocket [chemical binding]; other site 637382000780 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 637382000781 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637382000782 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637382000783 putative glycosyl transferase; Provisional; Region: PRK10073 637382000784 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637382000785 active site 637382000786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382000787 H-loop/switch region; other site 637382000788 ABC transporter; Region: ABC_tran_2; pfam12848 637382000789 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637382000790 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637382000791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382000792 Walker A/P-loop; other site 637382000793 ATP binding site [chemical binding]; other site 637382000794 ABC transporter; Region: ABC_tran; pfam00005 637382000795 ABC transporter signature motif; other site 637382000796 Walker B; other site 637382000797 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 637382000798 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 637382000799 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 637382000800 TrkA-N domain; Region: TrkA_N; pfam02254 637382000801 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 637382000802 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 637382000803 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 637382000804 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 637382000805 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 637382000806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 637382000807 YheO-like PAS domain; Region: PAS_6; pfam08348 637382000808 HTH domain; Region: HTH_22; pfam13309 637382000809 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 637382000810 sulfur relay protein TusC; Validated; Region: PRK00211 637382000811 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 637382000812 S17 interaction site [polypeptide binding]; other site 637382000813 S8 interaction site; other site 637382000814 16S rRNA interaction site [nucleotide binding]; other site 637382000815 streptomycin interaction site [chemical binding]; other site 637382000816 23S rRNA interaction site [nucleotide binding]; other site 637382000817 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 637382000818 30S ribosomal protein S7; Validated; Region: PRK05302 637382000819 elongation factor G; Reviewed; Region: PRK00007 637382000820 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 637382000821 G1 box; other site 637382000822 putative GEF interaction site [polypeptide binding]; other site 637382000823 GTP/Mg2+ binding site [chemical binding]; other site 637382000824 Switch I region; other site 637382000825 G2 box; other site 637382000826 G3 box; other site 637382000827 Switch II region; other site 637382000828 G4 box; other site 637382000829 G5 box; other site 637382000830 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 637382000831 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 637382000832 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 637382000833 elongation factor Tu; Reviewed; Region: PRK00049 637382000834 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 637382000835 G1 box; other site 637382000836 GEF interaction site [polypeptide binding]; other site 637382000837 GTP/Mg2+ binding site [chemical binding]; other site 637382000838 Switch I region; other site 637382000839 G2 box; other site 637382000840 G3 box; other site 637382000841 Switch II region; other site 637382000842 G4 box; other site 637382000843 G5 box; other site 637382000844 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 637382000845 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 637382000846 Antibiotic Binding Site [chemical binding]; other site 637382000847 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382000848 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 637382000849 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 637382000850 heme binding site [chemical binding]; other site 637382000851 ferroxidase pore; other site 637382000852 ferroxidase diiron center [ion binding]; other site 637382000853 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 637382000854 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 637382000855 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 637382000856 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 637382000857 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 637382000858 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 637382000859 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 637382000860 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 637382000861 protein-rRNA interface [nucleotide binding]; other site 637382000862 putative translocon binding site; other site 637382000863 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 637382000864 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 637382000865 G-X-X-G motif; other site 637382000866 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 637382000867 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 637382000868 23S rRNA interface [nucleotide binding]; other site 637382000869 5S rRNA interface [nucleotide binding]; other site 637382000870 putative antibiotic binding site [chemical binding]; other site 637382000871 L25 interface [polypeptide binding]; other site 637382000872 L27 interface [polypeptide binding]; other site 637382000873 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 637382000874 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 637382000875 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 637382000876 RNA binding site [nucleotide binding]; other site 637382000877 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 637382000878 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 637382000879 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 637382000880 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 637382000881 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 637382000882 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 637382000883 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 637382000884 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 637382000885 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 637382000886 5S rRNA interface [nucleotide binding]; other site 637382000887 23S rRNA interface [nucleotide binding]; other site 637382000888 L5 interface [polypeptide binding]; other site 637382000889 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 637382000890 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 637382000891 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 637382000892 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 637382000893 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 637382000894 SecY translocase; Region: SecY; pfam00344 637382000895 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 637382000896 30S ribosomal protein S13; Region: bact_S13; TIGR03631 637382000897 30S ribosomal protein S11; Validated; Region: PRK05309 637382000898 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 637382000899 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 637382000900 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637382000901 RNA binding surface [nucleotide binding]; other site 637382000902 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 637382000903 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 637382000904 alphaNTD homodimer interface [polypeptide binding]; other site 637382000905 alphaNTD - beta interaction site [polypeptide binding]; other site 637382000906 alphaNTD - beta' interaction site [polypeptide binding]; other site 637382000907 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 637382000908 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 637382000909 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 637382000910 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 637382000911 DNA binding residues [nucleotide binding] 637382000912 dimer interface [polypeptide binding]; other site 637382000913 metal binding site [ion binding]; metal-binding site 637382000914 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 637382000915 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 637382000916 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 637382000917 TrkA-N domain; Region: TrkA_N; pfam02254 637382000918 TrkA-C domain; Region: TrkA_C; pfam02080 637382000919 TrkA-N domain; Region: TrkA_N; pfam02254 637382000920 TrkA-C domain; Region: TrkA_C; pfam02080 637382000921 16S rRNA methyltransferase B; Provisional; Region: PRK10901 637382000922 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 637382000923 putative RNA binding site [nucleotide binding]; other site 637382000924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382000925 S-adenosylmethionine binding site [chemical binding]; other site 637382000926 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 637382000927 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 637382000928 putative active site [active] 637382000929 substrate binding site [chemical binding]; other site 637382000930 putative cosubstrate binding site; other site 637382000931 catalytic site [active] 637382000932 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 637382000933 substrate binding site [chemical binding]; other site 637382000934 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 637382000935 active site 637382000936 catalytic residues [active] 637382000937 metal binding site [ion binding]; metal-binding site 637382000938 hypothetical protein; Provisional; Region: PRK10736 637382000939 DNA protecting protein DprA; Region: dprA; TIGR00732 637382000940 hypothetical protein; Validated; Region: PRK03430 637382000941 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637382000942 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 637382000943 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637382000944 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637382000945 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 637382000946 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 637382000947 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 637382000948 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 637382000949 shikimate binding site; other site 637382000950 NAD(P) binding site [chemical binding]; other site 637382000951 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 637382000952 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 637382000953 trimer interface [polypeptide binding]; other site 637382000954 putative metal binding site [ion binding]; other site 637382000955 transposase/IS protein; Provisional; Region: PRK09183 637382000956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382000957 Walker A motif; other site 637382000958 ATP binding site [chemical binding]; other site 637382000959 Walker B motif; other site 637382000960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382000961 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382000962 DNA-binding interface [nucleotide binding]; DNA binding site 637382000963 Integrase core domain; Region: rve; pfam00665 637382000964 Abhydrolase family; Region: Abhydrolase_7; pfam12715 637382000965 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 637382000966 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 637382000967 Na binding site [ion binding]; other site 637382000968 Predicted membrane protein [Function unknown]; Region: COG3162 637382000969 acetyl-CoA synthetase; Provisional; Region: PRK00174 637382000970 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 637382000971 active site 637382000972 CoA binding site [chemical binding]; other site 637382000973 acyl-activating enzyme (AAE) consensus motif; other site 637382000974 AMP binding site [chemical binding]; other site 637382000975 acetate binding site [chemical binding]; other site 637382000976 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 637382000977 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 637382000978 two component system sensor kinase SsrB; Provisional; Region: PRK15369 637382000979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382000980 active site 637382000981 phosphorylation site [posttranslational modification] 637382000982 intermolecular recognition site; other site 637382000983 dimerization interface [polypeptide binding]; other site 637382000984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382000985 DNA binding residues [nucleotide binding] 637382000986 dimerization interface [polypeptide binding]; other site 637382000987 two component system sensor kinase SsrA; Provisional; Region: PRK15347 637382000988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382000989 dimer interface [polypeptide binding]; other site 637382000990 phosphorylation site [posttranslational modification] 637382000991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382000992 ATP binding site [chemical binding]; other site 637382000993 Mg2+ binding site [ion binding]; other site 637382000994 G-X-G motif; other site 637382000995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382000996 active site 637382000997 phosphorylation site [posttranslational modification] 637382000998 intermolecular recognition site; other site 637382000999 dimerization interface [polypeptide binding]; other site 637382001000 Hpt domain; Region: Hpt; pfam01627 637382001001 outer membrane secretin SsaC; Provisional; Region: PRK15346 637382001002 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 637382001003 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 637382001004 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 637382001005 type III secretion system protein SsaD; Provisional; Region: PRK15367 637382001006 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 637382001007 Helix-turn-helix domain; Region: HTH_18; pfam12833 637382001008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382001009 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 637382001010 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 637382001011 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 637382001012 type III secretion system protein SsaK; Provisional; Region: PRK15354 637382001013 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 637382001014 FHIPEP family; Region: FHIPEP; pfam00771 637382001015 type III secretion system ATPase; Validated; Region: PRK06820 637382001016 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 637382001017 Walker A motif/ATP binding site; other site 637382001018 Walker B motif; other site 637382001019 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637382001020 type III secretion system protein SsaQ; Validated; Region: PRK08035 637382001021 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 637382001022 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 637382001023 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 637382001024 potential frameshift: common BLAST hit: gi|294502345|ref|YP_003566407.1| putative type III secretion apparatus protein 637382001025 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 637382001026 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 637382001027 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 637382001028 putative inner membrane protein; Provisional; Region: PRK11099 637382001029 Sulphur transport; Region: Sulf_transp; pfam04143 637382001030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382001031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382001032 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 637382001033 putative effector binding pocket; other site 637382001034 dimerization interface [polypeptide binding]; other site 637382001035 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 637382001036 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 637382001037 cystathionine beta-lyase; Provisional; Region: PRK09028 637382001038 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637382001039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382001040 catalytic residue [active] 637382001041 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 637382001042 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637382001043 Walker A/P-loop; other site 637382001044 ATP binding site [chemical binding]; other site 637382001045 Q-loop/lid; other site 637382001046 ABC transporter signature motif; other site 637382001047 Walker B; other site 637382001048 D-loop; other site 637382001049 H-loop/switch region; other site 637382001050 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637382001051 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382001052 ABC-ATPase subunit interface; other site 637382001053 dimer interface [polypeptide binding]; other site 637382001054 putative PBP binding regions; other site 637382001055 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 637382001056 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 637382001057 putative hemin binding site; other site 637382001058 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 637382001059 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 637382001060 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 637382001061 potential frameshift: common BLAST hit: gi|294502354|ref|YP_003566416.1| hemin receptor 637382001062 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637382001063 ligand-binding site [chemical binding]; other site 637382001064 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 637382001065 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 637382001066 NADH(P)-binding; Region: NAD_binding_10; pfam13460 637382001067 NAD(P) binding site [chemical binding]; other site 637382001068 putative active site [active] 637382001069 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 637382001070 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 637382001071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382001072 FeS/SAM binding site; other site 637382001073 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 637382001074 FAD binding site [chemical binding]; other site 637382001075 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 637382001076 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 637382001077 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 637382001078 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637382001079 active site 637382001080 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 637382001081 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 637382001082 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 637382001083 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 637382001084 putative metal binding site [ion binding]; other site 637382001085 potential frameshift: common BLAST hit: gi|294502366|ref|YP_003566428.1| tellurium resistance protein 637382001086 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 637382001087 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 637382001088 putative metal binding site [ion binding]; other site 637382001089 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 637382001090 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 637382001091 putative metal binding site [ion binding]; other site 637382001092 tellurite resistance protein terB; Region: terB; cd07176 637382001093 putative metal binding site [ion binding]; other site 637382001094 Integral membrane protein TerC family; Region: TerC; cl10468 637382001095 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 637382001096 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 637382001097 putative metal binding site [ion binding]; other site 637382001098 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 637382001099 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 637382001100 putative metal binding site [ion binding]; other site 637382001101 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 637382001102 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637382001103 PapC N-terminal domain; Region: PapC_N; pfam13954 637382001104 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382001105 PapC C-terminal domain; Region: PapC_C; pfam13953 637382001106 putative fimbrial chaperone protein; Provisional; Region: PRK09918 637382001107 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382001108 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 637382001109 Berberine and berberine like; Region: BBE; pfam08031 637382001110 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 637382001111 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637382001112 Interdomain contacts; other site 637382001113 Cytokine receptor motif; other site 637382001114 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 637382001115 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637382001116 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637382001117 Autotransporter beta-domain; Region: Autotransporter; smart00869 637382001118 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 637382001119 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 637382001120 UbiA prenyltransferase family; Region: UbiA; pfam01040 637382001121 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 637382001122 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 637382001123 putative acyl-acceptor binding pocket; other site 637382001124 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 637382001125 LexA repressor; Validated; Region: PRK00215 637382001126 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 637382001127 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 637382001128 Catalytic site [active] 637382001129 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 637382001130 metal binding site 2 [ion binding]; metal-binding site 637382001131 putative DNA binding helix; other site 637382001132 metal binding site 1 [ion binding]; metal-binding site 637382001133 dimer interface [polypeptide binding]; other site 637382001134 structural Zn2+ binding site [ion binding]; other site 637382001135 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 637382001136 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 637382001137 FMN binding site [chemical binding]; other site 637382001138 active site 637382001139 catalytic residues [active] 637382001140 substrate binding site [chemical binding]; other site 637382001141 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 637382001142 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 637382001143 NADP binding site [chemical binding]; other site 637382001144 dimer interface [polypeptide binding]; other site 637382001145 replicative DNA helicase; Provisional; Region: PRK08006 637382001146 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 637382001147 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 637382001148 Walker A motif; other site 637382001149 ATP binding site [chemical binding]; other site 637382001150 Walker B motif; other site 637382001151 DNA binding loops [nucleotide binding] 637382001152 alanine racemase; Reviewed; Region: alr; PRK00053 637382001153 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 637382001154 active site 637382001155 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637382001156 substrate binding site [chemical binding]; other site 637382001157 catalytic residues [active] 637382001158 dimer interface [polypeptide binding]; other site 637382001159 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 637382001160 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637382001161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382001162 homodimer interface [polypeptide binding]; other site 637382001163 catalytic residue [active] 637382001164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 637382001165 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 637382001166 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 637382001167 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 637382001168 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 637382001169 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 637382001170 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637382001171 dimer interface [polypeptide binding]; other site 637382001172 ssDNA binding site [nucleotide binding]; other site 637382001173 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637382001174 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 637382001175 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 637382001176 lactaldehyde reductase; Region: lactal_redase; TIGR02638 637382001177 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 637382001178 dimer interface [polypeptide binding]; other site 637382001179 active site 637382001180 metal binding site [ion binding]; metal-binding site 637382001181 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 637382001182 intersubunit interface [polypeptide binding]; other site 637382001183 active site 637382001184 Zn2+ binding site [ion binding]; other site 637382001185 L-rhamnose isomerase; Provisional; Region: PRK01076 637382001186 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 637382001187 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 637382001188 N- and C-terminal domain interface [polypeptide binding]; other site 637382001189 active site 637382001190 putative catalytic site [active] 637382001191 metal binding site [ion binding]; metal-binding site 637382001192 ATP binding site [chemical binding]; other site 637382001193 rhamnulokinase; Provisional; Region: rhaB; PRK10640 637382001194 carbohydrate binding site [chemical binding]; other site 637382001195 transcriptional activator RhaS; Provisional; Region: PRK13503 637382001196 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637382001197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382001198 transcriptional activator RhaR; Provisional; Region: PRK13501 637382001199 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637382001200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382001201 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 637382001202 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 637382001203 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 637382001204 Viral enhancin protein; Region: Enhancin; pfam03272 637382001205 Peptidase M60-like family; Region: M60-like; pfam13402 637382001206 putative transcriptional regulator; Provisional; Region: PRK11640 637382001207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637382001208 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 637382001209 4Fe-4S binding domain; Region: Fer4; pfam00037 637382001210 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637382001211 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637382001212 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 637382001213 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 637382001214 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 637382001215 [4Fe-4S] binding site [ion binding]; other site 637382001216 molybdopterin cofactor binding site; other site 637382001217 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 637382001218 molybdopterin cofactor binding site; other site 637382001219 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 637382001220 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 637382001221 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 637382001222 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 637382001223 DsbD alpha interface [polypeptide binding]; other site 637382001224 catalytic residues [active] 637382001225 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 637382001226 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 637382001227 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 637382001228 Aspartase; Region: Aspartase; cd01357 637382001229 active sites [active] 637382001230 tetramer interface [polypeptide binding]; other site 637382001231 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 637382001232 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 637382001233 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 637382001234 ring oligomerisation interface [polypeptide binding]; other site 637382001235 ATP/Mg binding site [chemical binding]; other site 637382001236 stacking interactions; other site 637382001237 hinge regions; other site 637382001238 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 637382001239 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382001240 Radical SAM superfamily; Region: Radical_SAM; pfam04055 637382001241 FeS/SAM binding site; other site 637382001242 elongation factor P; Validated; Region: PRK00529 637382001243 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 637382001244 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 637382001245 RNA binding site [nucleotide binding]; other site 637382001246 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 637382001247 RNA binding site [nucleotide binding]; other site 637382001248 multidrug efflux system protein; Provisional; Region: PRK11431 637382001249 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 637382001250 Iron-sulfur protein interface; other site 637382001251 proximal quinone binding site [chemical binding]; other site 637382001252 C-subunit interface; other site 637382001253 distal quinone binding site; other site 637382001254 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 637382001255 D-subunit interface [polypeptide binding]; other site 637382001256 Iron-sulfur protein interface; other site 637382001257 proximal quinone binding site [chemical binding]; other site 637382001258 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 637382001259 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637382001260 catalytic loop [active] 637382001261 iron binding site [ion binding]; other site 637382001262 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 637382001263 L-aspartate oxidase; Provisional; Region: PRK06175 637382001264 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 637382001265 poxB regulator PoxA; Provisional; Region: PRK09350 637382001266 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637382001267 motif 1; other site 637382001268 dimer interface [polypeptide binding]; other site 637382001269 active site 637382001270 motif 2; other site 637382001271 motif 3; other site 637382001272 putative mechanosensitive channel protein; Provisional; Region: PRK10929 637382001273 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 637382001274 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637382001275 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 637382001276 GTPase RsgA; Reviewed; Region: PRK12288 637382001277 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 637382001278 RNA binding site [nucleotide binding]; other site 637382001279 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 637382001280 GTPase/Zn-binding domain interface [polypeptide binding]; other site 637382001281 GTP/Mg2+ binding site [chemical binding]; other site 637382001282 G4 box; other site 637382001283 G5 box; other site 637382001284 G1 box; other site 637382001285 Switch I region; other site 637382001286 G2 box; other site 637382001287 G3 box; other site 637382001288 Switch II region; other site 637382001289 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 637382001290 catalytic site [active] 637382001291 putative active site [active] 637382001292 putative substrate binding site [chemical binding]; other site 637382001293 dimer interface [polypeptide binding]; other site 637382001294 epoxyqueuosine reductase; Region: TIGR00276 637382001295 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 637382001296 putative carbohydrate kinase; Provisional; Region: PRK10565 637382001297 Uncharacterized conserved protein [Function unknown]; Region: COG0062 637382001298 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 637382001299 putative substrate binding site [chemical binding]; other site 637382001300 putative ATP binding site [chemical binding]; other site 637382001301 ADP-binding protein; Provisional; Region: PRK10646 637382001302 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 637382001303 AMIN domain; Region: AMIN; pfam11741 637382001304 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637382001305 active site 637382001306 metal binding site [ion binding]; metal-binding site 637382001307 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 637382001308 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637382001309 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 637382001310 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637382001311 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 637382001312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382001313 ATP binding site [chemical binding]; other site 637382001314 Mg2+ binding site [ion binding]; other site 637382001315 G-X-G motif; other site 637382001316 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 637382001317 ATP binding site [chemical binding]; other site 637382001318 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 637382001319 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 637382001320 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 637382001321 bacterial Hfq-like; Region: Hfq; cd01716 637382001322 hexamer interface [polypeptide binding]; other site 637382001323 Sm1 motif; other site 637382001324 RNA binding site [nucleotide binding]; other site 637382001325 Sm2 motif; other site 637382001326 GTPase HflX; Provisional; Region: PRK11058 637382001327 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 637382001328 HflX GTPase family; Region: HflX; cd01878 637382001329 G1 box; other site 637382001330 GTP/Mg2+ binding site [chemical binding]; other site 637382001331 Switch I region; other site 637382001332 G2 box; other site 637382001333 G3 box; other site 637382001334 Switch II region; other site 637382001335 G4 box; other site 637382001336 G5 box; other site 637382001337 FtsH protease regulator HflK; Provisional; Region: PRK10930 637382001338 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 637382001339 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 637382001340 FtsH protease regulator HflC; Provisional; Region: PRK11029 637382001341 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 637382001342 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 637382001343 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 637382001344 GDP-binding site [chemical binding]; other site 637382001345 ACT binding site; other site 637382001346 IMP binding site; other site 637382001347 transcriptional repressor NsrR; Provisional; Region: PRK11014 637382001348 Rrf2 family protein; Region: rrf2_super; TIGR00738 637382001349 potential frameshift: common BLAST hit: gi|294502488|ref|YP_003566550.1| ribonuclease R 637382001350 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 637382001351 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 637382001352 RNA binding site [nucleotide binding]; other site 637382001353 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 637382001354 RNB domain; Region: RNB; pfam00773 637382001355 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 637382001356 RNA binding site [nucleotide binding]; other site 637382001357 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 637382001358 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 637382001359 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 637382001360 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 637382001361 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 637382001362 active site 637382001363 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 637382001364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382001365 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637382001366 Walker A motif; other site 637382001367 ATP binding site [chemical binding]; other site 637382001368 Walker B motif; other site 637382001369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382001370 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382001371 DNA-binding interface [nucleotide binding]; DNA binding site 637382001372 Integrase core domain; Region: rve; pfam00665 637382001373 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 637382001374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 637382001375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 637382001376 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 637382001377 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 637382001378 Methyltransferase domain; Region: Methyltransf_26; pfam13659 637382001379 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 637382001380 ATP binding site [chemical binding]; other site 637382001381 Mg2+ binding site [ion binding]; other site 637382001382 G-X-G motif; other site 637382001383 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 637382001384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 637382001385 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 637382001386 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 637382001387 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 637382001388 Predicted membrane protein [Function unknown]; Region: COG4269 637382001389 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 637382001390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382001391 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 637382001392 active site 637382001393 P-loop; other site 637382001394 phosphorylation site [posttranslational modification] 637382001395 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 637382001396 active site 637382001397 P-loop; other site 637382001398 phosphorylation site [posttranslational modification] 637382001399 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 637382001400 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637382001401 regulatory phosphorylation site [posttranslational modification]; other site 637382001402 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 637382001403 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 637382001404 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 637382001405 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 637382001406 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637382001407 active site 637382001408 phosphorylation site [posttranslational modification] 637382001409 hypothetical protein; Provisional; Region: PRK11667 637382001410 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 637382001411 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 637382001412 putative active site; other site 637382001413 catalytic residue [active] 637382001414 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 637382001415 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 637382001416 ligand binding site [chemical binding]; other site 637382001417 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382001418 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382001419 TM-ABC transporter signature motif; other site 637382001420 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382001421 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382001422 TM-ABC transporter signature motif; other site 637382001423 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 637382001424 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382001425 Walker A/P-loop; other site 637382001426 ATP binding site [chemical binding]; other site 637382001427 Q-loop/lid; other site 637382001428 ABC transporter signature motif; other site 637382001429 Walker B; other site 637382001430 D-loop; other site 637382001431 H-loop/switch region; other site 637382001432 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382001433 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637382001434 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 637382001435 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 637382001436 putative N- and C-terminal domain interface [polypeptide binding]; other site 637382001437 putative active site [active] 637382001438 putative MgATP binding site [chemical binding]; other site 637382001439 catalytic site [active] 637382001440 metal binding site [ion binding]; metal-binding site 637382001441 putative carbohydrate binding site [chemical binding]; other site 637382001442 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 637382001443 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 637382001444 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 637382001445 putative active site [active] 637382001446 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 637382001447 O-Antigen ligase; Region: Wzy_C; pfam04932 637382001448 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 637382001449 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382001450 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382001451 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 637382001452 Pectinesterase; Region: Pectinesterase; pfam01095 637382001453 putative pectinesterase; Region: PLN02432; cl01911 637382001454 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637382001455 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637382001456 metal binding site [ion binding]; metal-binding site 637382001457 active site 637382001458 I-site; other site 637382001459 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 637382001460 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 637382001461 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 637382001462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382001463 S-adenosylmethionine binding site [chemical binding]; other site 637382001464 DNA polymerase III subunit psi; Validated; Region: PRK06856 637382001465 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637382001466 Coenzyme A binding pocket [chemical binding]; other site 637382001467 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 637382001468 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 637382001469 G1 box; other site 637382001470 putative GEF interaction site [polypeptide binding]; other site 637382001471 GTP/Mg2+ binding site [chemical binding]; other site 637382001472 Switch I region; other site 637382001473 G2 box; other site 637382001474 G3 box; other site 637382001475 Switch II region; other site 637382001476 G4 box; other site 637382001477 G5 box; other site 637382001478 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 637382001479 periplasmic protein; Provisional; Region: PRK10568 637382001480 BON domain; Region: BON; pfam04972 637382001481 BON domain; Region: BON; pfam04972 637382001482 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 637382001483 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 637382001484 active site 637382001485 nucleophile elbow; other site 637382001486 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 637382001487 active site 637382001488 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 637382001489 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 637382001490 Nucleoside recognition; Region: Gate; pfam07670 637382001491 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 637382001492 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 637382001493 intersubunit interface [polypeptide binding]; other site 637382001494 active site 637382001495 catalytic residue [active] 637382001496 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637382001497 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637382001498 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637382001499 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 637382001500 phosphopentomutase; Provisional; Region: PRK05362 637382001501 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 637382001502 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 637382001503 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 637382001504 hypothetical protein; Provisional; Region: PRK11246 637382001505 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 637382001506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382001507 motif II; other site 637382001508 DNA repair protein RadA; Provisional; Region: PRK11823 637382001509 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 637382001510 Walker A motif/ATP binding site; other site 637382001511 ATP binding site [chemical binding]; other site 637382001512 Walker B motif; other site 637382001513 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 637382001514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637382001515 non-specific DNA binding site [nucleotide binding]; other site 637382001516 salt bridge; other site 637382001517 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 637382001518 sequence-specific DNA binding site [nucleotide binding]; other site 637382001519 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637382001520 active site 637382001521 nucleotide binding site [chemical binding]; other site 637382001522 HIGH motif; other site 637382001523 KMSKS motif; other site 637382001524 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 637382001525 Fic family protein [Function unknown]; Region: COG3177 637382001526 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 637382001527 Fic/DOC family; Region: Fic; pfam02661 637382001528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382001529 H-loop/switch region; other site 637382001530 ABC transporter; Region: ABC_tran_2; pfam12848 637382001531 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637382001532 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637382001533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382001534 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637382001535 Walker A/P-loop; other site 637382001536 ATP binding site [chemical binding]; other site 637382001537 Q-loop/lid; other site 637382001538 ABC transporter signature motif; other site 637382001539 putative outer membrane lipoprotein; Provisional; Region: PRK09967 637382001540 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637382001541 ligand binding site [chemical binding]; other site 637382001542 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 637382001543 HAMP domain; Region: HAMP; pfam00672 637382001544 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637382001545 metal binding site [ion binding]; metal-binding site 637382001546 active site 637382001547 I-site; other site 637382001548 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 637382001549 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 637382001550 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 637382001551 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637382001552 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 637382001553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382001554 motif II; other site 637382001555 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 637382001556 lytic murein transglycosylase; Provisional; Region: PRK11619 637382001557 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637382001558 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637382001559 catalytic residue [active] 637382001560 Trp operon repressor; Provisional; Region: PRK01381 637382001561 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 637382001562 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637382001563 catalytic core [active] 637382001564 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 637382001565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382001566 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 637382001567 hypothetical protein; Provisional; Region: PRK10756 637382001568 CreA protein; Region: CreA; pfam05981 637382001569 two-component response regulator; Provisional; Region: PRK11173 637382001570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382001571 active site 637382001572 phosphorylation site [posttranslational modification] 637382001573 intermolecular recognition site; other site 637382001574 dimerization interface [polypeptide binding]; other site 637382001575 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382001576 DNA binding site [nucleotide binding] 637382001577 potential frameshift: common BLAST hit: gi|294502556|ref|YP_003566618.1| bifunctional aspartokinase I/homoserine dehydrogenase I 637382001578 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 637382001579 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 637382001580 putative catalytic residues [active] 637382001581 putative nucleotide binding site [chemical binding]; other site 637382001582 putative aspartate binding site [chemical binding]; other site 637382001583 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 637382001584 dimer interface [polypeptide binding]; other site 637382001585 putative threonine allosteric regulatory site; other site 637382001586 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 637382001587 putative threonine allosteric regulatory site; other site 637382001588 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 637382001589 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 637382001590 homoserine kinase; Provisional; Region: PRK01212 637382001591 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637382001592 threonine synthase; Validated; Region: PRK09225 637382001593 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 637382001594 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382001595 catalytic residue [active] 637382001596 hypothetical protein; Validated; Region: PRK02101 637382001597 transaldolase-like protein; Provisional; Region: PTZ00411 637382001598 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 637382001599 active site 637382001600 dimer interface [polypeptide binding]; other site 637382001601 catalytic residue [active] 637382001602 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 637382001603 MPT binding site; other site 637382001604 trimer interface [polypeptide binding]; other site 637382001605 metabolite-proton symporter; Region: 2A0106; TIGR00883 637382001606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382001607 putative substrate translocation pore; other site 637382001608 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637382001609 hypothetical protein; Provisional; Region: PRK10659 637382001610 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 637382001611 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 637382001612 nucleotide binding site [chemical binding]; other site 637382001613 chaperone protein DnaJ; Provisional; Region: PRK10767 637382001614 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 637382001615 HSP70 interaction site [polypeptide binding]; other site 637382001616 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 637382001617 substrate binding site [polypeptide binding]; other site 637382001618 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 637382001619 Zn binding sites [ion binding]; other site 637382001620 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 637382001621 dimer interface [polypeptide binding]; other site 637382001622 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 637382001623 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 637382001624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382001625 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 637382001626 putative dimerization interface [polypeptide binding]; other site 637382001627 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 637382001628 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 637382001629 active site 637382001630 Riboflavin kinase; Region: Flavokinase; smart00904 637382001631 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 637382001632 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637382001633 active site 637382001634 HIGH motif; other site 637382001635 nucleotide binding site [chemical binding]; other site 637382001636 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 637382001637 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 637382001638 active site 637382001639 KMSKS motif; other site 637382001640 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 637382001641 tRNA binding surface [nucleotide binding]; other site 637382001642 anticodon binding site; other site 637382001643 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 637382001644 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 637382001645 lipoprotein signal peptidase; Provisional; Region: PRK14787 637382001646 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 637382001647 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 637382001648 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 637382001649 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 637382001650 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382001651 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 637382001652 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 637382001653 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 637382001654 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 637382001655 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 637382001656 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 637382001657 catalytic site [active] 637382001658 subunit interface [polypeptide binding]; other site 637382001659 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 637382001660 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637382001661 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 637382001662 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 637382001663 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637382001664 ATP-grasp domain; Region: ATP-grasp_4; cl17255 637382001665 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 637382001666 IMP binding site; other site 637382001667 dimer interface [polypeptide binding]; other site 637382001668 interdomain contacts; other site 637382001669 partial ornithine binding site; other site 637382001670 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 637382001671 Uncharacterized conserved protein [Function unknown]; Region: COG2966 637382001672 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 637382001673 hypothetical protein; Provisional; Region: PRK09917 637382001674 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 637382001675 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 637382001676 folate binding site [chemical binding]; other site 637382001677 NADP+ binding site [chemical binding]; other site 637382001678 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382001679 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 637382001680 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 637382001681 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 637382001682 active site 637382001683 metal binding site [ion binding]; metal-binding site 637382001684 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 637382001685 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 637382001686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382001687 S-adenosylmethionine binding site [chemical binding]; other site 637382001688 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 637382001689 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 637382001690 SurA N-terminal domain; Region: SurA_N; pfam09312 637382001691 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 637382001692 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 637382001693 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 637382001694 OstA-like protein; Region: OstA; pfam03968 637382001695 Organic solvent tolerance protein; Region: OstA_C; pfam04453 637382001696 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 637382001697 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 637382001698 putative metal binding site [ion binding]; other site 637382001699 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 637382001700 HSP70 interaction site [polypeptide binding]; other site 637382001701 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637382001702 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637382001703 active site 637382001704 Uncharacterized conserved protein [Function unknown]; Region: COG5419 637382001705 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 637382001706 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 637382001707 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 637382001708 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 637382001709 Protein of unknown function (DUF877); Region: DUF877; pfam05943 637382001710 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 637382001711 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 637382001712 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 637382001713 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 637382001714 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 637382001715 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 637382001716 Clp amino terminal domain; Region: Clp_N; pfam02861 637382001717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382001718 Walker A motif; other site 637382001719 ATP binding site [chemical binding]; other site 637382001720 Walker B motif; other site 637382001721 arginine finger; other site 637382001722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382001723 Walker A motif; other site 637382001724 ATP binding site [chemical binding]; other site 637382001725 Walker B motif; other site 637382001726 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637382001727 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 637382001728 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637382001729 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 637382001730 potential frameshift: common BLAST hit: gi|170025772|ref|YP_001722277.1| pentapeptide repeat-containing protein 637382001731 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 637382001732 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 637382001733 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 637382001734 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 637382001735 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 637382001736 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 637382001737 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 637382001738 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 637382001739 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 637382001740 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 637382001741 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 637382001742 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 637382001743 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 637382001744 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 637382001745 hypothetical protein; Provisional; Region: PRK07034 637382001746 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 637382001747 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637382001748 ligand binding site [chemical binding]; other site 637382001749 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 637382001750 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 637382001751 G1 box; other site 637382001752 GTP/Mg2+ binding site [chemical binding]; other site 637382001753 G2 box; other site 637382001754 G3 box; other site 637382001755 Switch II region; other site 637382001756 G4 box; other site 637382001757 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 637382001758 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 637382001759 ATP-dependent helicase HepA; Validated; Region: PRK04914 637382001760 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637382001761 ATP binding site [chemical binding]; other site 637382001762 putative Mg++ binding site [ion binding]; other site 637382001763 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382001764 nucleotide binding region [chemical binding]; other site 637382001765 ATP-binding site [chemical binding]; other site 637382001766 DNA polymerase II; Reviewed; Region: PRK05762 637382001767 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 637382001768 active site 637382001769 catalytic site [active] 637382001770 substrate binding site [chemical binding]; other site 637382001771 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 637382001772 active site 637382001773 metal-binding site 637382001774 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637382001775 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 637382001776 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 637382001777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382001778 Walker A/P-loop; other site 637382001779 ATP binding site [chemical binding]; other site 637382001780 Q-loop/lid; other site 637382001781 ABC transporter signature motif; other site 637382001782 Walker B; other site 637382001783 D-loop; other site 637382001784 H-loop/switch region; other site 637382001785 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 637382001786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382001787 dimer interface [polypeptide binding]; other site 637382001788 conserved gate region; other site 637382001789 putative PBP binding loops; other site 637382001790 ABC-ATPase subunit interface; other site 637382001791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382001792 dimer interface [polypeptide binding]; other site 637382001793 conserved gate region; other site 637382001794 putative PBP binding loops; other site 637382001795 ABC-ATPase subunit interface; other site 637382001796 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 637382001797 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 637382001798 transcriptional regulator SgrR; Provisional; Region: PRK13626 637382001799 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 637382001800 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 637382001801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382001802 putative substrate translocation pore; other site 637382001803 transposase/IS protein; Provisional; Region: PRK09183 637382001804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382001805 Walker A motif; other site 637382001806 ATP binding site [chemical binding]; other site 637382001807 Walker B motif; other site 637382001808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382001809 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382001810 DNA-binding interface [nucleotide binding]; DNA binding site 637382001811 Integrase core domain; Region: rve; pfam00665 637382001812 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 637382001813 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 637382001814 substrate binding site [chemical binding]; other site 637382001815 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 637382001816 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 637382001817 substrate binding site [chemical binding]; other site 637382001818 ligand binding site [chemical binding]; other site 637382001819 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 637382001820 tartrate dehydrogenase; Region: TTC; TIGR02089 637382001821 2-isopropylmalate synthase; Validated; Region: PRK00915 637382001822 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 637382001823 active site 637382001824 catalytic residues [active] 637382001825 metal binding site [ion binding]; metal-binding site 637382001826 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 637382001827 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 637382001828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382001829 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 637382001830 putative substrate binding pocket [chemical binding]; other site 637382001831 putative dimerization interface [polypeptide binding]; other site 637382001832 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 637382001833 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637382001834 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 637382001835 acyl-activating enzyme (AAE) consensus motif; other site 637382001836 acyl-activating enzyme (AAE) consensus motif; other site 637382001837 putative AMP binding site [chemical binding]; other site 637382001838 putative active site [active] 637382001839 putative CoA binding site [chemical binding]; other site 637382001840 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 637382001841 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637382001842 PYR/PP interface [polypeptide binding]; other site 637382001843 dimer interface [polypeptide binding]; other site 637382001844 TPP binding site [chemical binding]; other site 637382001845 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637382001846 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 637382001847 TPP-binding site [chemical binding]; other site 637382001848 dimer interface [polypeptide binding]; other site 637382001849 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 637382001850 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 637382001851 putative valine binding site [chemical binding]; other site 637382001852 dimer interface [polypeptide binding]; other site 637382001853 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 637382001854 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382001855 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 637382001856 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382001857 DNA binding site [nucleotide binding] 637382001858 domain linker motif; other site 637382001859 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 637382001860 dimerization interface [polypeptide binding]; other site 637382001861 ligand binding site [chemical binding]; other site 637382001862 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 637382001863 cell division protein MraZ; Reviewed; Region: PRK00326 637382001864 MraZ protein; Region: MraZ; pfam02381 637382001865 MraZ protein; Region: MraZ; pfam02381 637382001866 MraW methylase family; Region: Methyltransf_5; pfam01795 637382001867 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 637382001868 cell division protein FtsL; Provisional; Region: PRK10772 637382001869 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 637382001870 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637382001871 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 637382001872 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 637382001873 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637382001874 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637382001875 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637382001876 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 637382001877 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637382001878 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637382001879 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637382001880 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 637382001881 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 637382001882 Mg++ binding site [ion binding]; other site 637382001883 putative catalytic motif [active] 637382001884 putative substrate binding site [chemical binding]; other site 637382001885 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 637382001886 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 637382001887 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637382001888 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637382001889 cell division protein FtsW; Provisional; Region: PRK10774 637382001890 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 637382001891 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 637382001892 active site 637382001893 homodimer interface [polypeptide binding]; other site 637382001894 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 637382001895 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637382001896 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637382001897 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637382001898 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 637382001899 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 637382001900 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 637382001901 cell division protein FtsQ; Provisional; Region: PRK10775 637382001902 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 637382001903 Cell division protein FtsQ; Region: FtsQ; pfam03799 637382001904 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 637382001905 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637382001906 Cell division protein FtsA; Region: FtsA; pfam14450 637382001907 cell division protein FtsZ; Validated; Region: PRK09330 637382001908 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 637382001909 nucleotide binding site [chemical binding]; other site 637382001910 SulA interaction site; other site 637382001911 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 637382001912 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 637382001913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 637382001914 SecA regulator SecM; Provisional; Region: PRK02943 637382001915 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 637382001916 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 637382001917 SEC-C motif; Region: SEC-C; pfam02810 637382001918 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 637382001919 active site 637382001920 8-oxo-dGMP binding site [chemical binding]; other site 637382001921 nudix motif; other site 637382001922 metal binding site [ion binding]; metal-binding site 637382001923 transposase/IS protein; Provisional; Region: PRK09183 637382001924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382001925 Walker A motif; other site 637382001926 ATP binding site [chemical binding]; other site 637382001927 Walker B motif; other site 637382001928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382001929 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382001930 DNA-binding interface [nucleotide binding]; DNA binding site 637382001931 Integrase core domain; Region: rve; pfam00665 637382001932 Predicted membrane protein [Function unknown]; Region: COG2259 637382001933 Predicted membrane protein [Function unknown]; Region: COG5393 637382001934 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 637382001935 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 637382001936 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 637382001937 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637382001938 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637382001939 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 637382001940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637382001941 DNA-binding site [nucleotide binding]; DNA binding site 637382001942 FCD domain; Region: FCD; pfam07729 637382001943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382001944 D-galactonate transporter; Region: 2A0114; TIGR00893 637382001945 putative substrate translocation pore; other site 637382001946 Glucuronate isomerase; Region: UxaC; pfam02614 637382001947 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 637382001948 altronate oxidoreductase; Provisional; Region: PRK03643 637382001949 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 637382001950 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 637382001951 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 637382001952 galactarate dehydratase; Region: galactar-dH20; TIGR03248 637382001953 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 637382001954 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 637382001955 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382001956 serine/threonine transporter SstT; Provisional; Region: PRK13628 637382001957 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 637382001958 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637382001959 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637382001960 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 637382001961 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 637382001962 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637382001963 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637382001964 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 637382001965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382001966 S-adenosylmethionine binding site [chemical binding]; other site 637382001967 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 637382001968 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 637382001969 active site 637382001970 FMN binding site [chemical binding]; other site 637382001971 2,4-decadienoyl-CoA binding site; other site 637382001972 catalytic residue [active] 637382001973 4Fe-4S cluster binding site [ion binding]; other site 637382001974 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 637382001975 acid-resistance membrane protein; Provisional; Region: PRK10209 637382001976 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 637382001977 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637382001978 substrate binding site [chemical binding]; other site 637382001979 activation loop (A-loop); other site 637382001980 Protein phosphatase 2C; Region: PP2C_2; pfam13672 637382001981 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 637382001982 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 637382001983 metal ion-dependent adhesion site (MIDAS); other site 637382001984 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 637382001985 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 637382001986 putative metal binding site [ion binding]; other site 637382001987 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 637382001988 metal ion-dependent adhesion site (MIDAS); other site 637382001989 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 637382001990 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 637382001991 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 637382001992 haemagglutination activity domain; Region: Haemagg_act; pfam05860 637382001993 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 637382001994 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382001995 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382001996 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382001997 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 637382001998 Autotransporter beta-domain; Region: Autotransporter; smart00869 637382001999 Putative glucoamylase; Region: Glycoamylase; pfam10091 637382002000 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 637382002001 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 637382002002 Walker A/P-loop; other site 637382002003 ATP binding site [chemical binding]; other site 637382002004 Q-loop/lid; other site 637382002005 ABC transporter signature motif; other site 637382002006 Walker B; other site 637382002007 D-loop; other site 637382002008 H-loop/switch region; other site 637382002009 TOBE domain; Region: TOBE_2; pfam08402 637382002010 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 637382002011 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637382002012 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382002013 DNA binding site [nucleotide binding] 637382002014 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637382002015 ligand binding site [chemical binding]; other site 637382002016 dimerization interface [polypeptide binding]; other site 637382002017 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637382002018 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 637382002019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382002020 dimer interface [polypeptide binding]; other site 637382002021 conserved gate region; other site 637382002022 putative PBP binding loops; other site 637382002023 ABC-ATPase subunit interface; other site 637382002024 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637382002025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382002026 dimer interface [polypeptide binding]; other site 637382002027 conserved gate region; other site 637382002028 putative PBP binding loops; other site 637382002029 ABC-ATPase subunit interface; other site 637382002030 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 637382002031 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 637382002032 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 637382002033 Outer membrane efflux protein; Region: OEP; pfam02321 637382002034 Outer membrane efflux protein; Region: OEP; pfam02321 637382002035 Predicted membrane protein [Function unknown]; Region: COG1289 637382002036 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 637382002037 multidrug resistance protein MdtN; Provisional; Region: PRK10476 637382002038 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382002039 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382002040 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 637382002041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637382002042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382002043 homodimer interface [polypeptide binding]; other site 637382002044 catalytic residue [active] 637382002045 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 637382002046 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 637382002047 putative hydrophobic ligand binding site [chemical binding]; other site 637382002048 protein interface [polypeptide binding]; other site 637382002049 gate; other site 637382002050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 637382002051 YheO-like PAS domain; Region: PAS_6; pfam08348 637382002052 HTH domain; Region: HTH_22; pfam13309 637382002053 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 637382002054 homotrimer interaction site [polypeptide binding]; other site 637382002055 putative active site [active] 637382002056 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 637382002057 homotrimer interaction site [polypeptide binding]; other site 637382002058 putative active site [active] 637382002059 putative monooxygenase; Provisional; Region: PRK11118 637382002060 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 637382002061 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 637382002062 catalytic residues [active] 637382002063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382002064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382002065 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637382002066 dimerization interface [polypeptide binding]; other site 637382002067 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 637382002068 active site 637382002069 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 637382002070 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 637382002071 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 637382002072 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 637382002073 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637382002074 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637382002075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637382002076 DNA binding residues [nucleotide binding] 637382002077 potential frameshift: common BLAST hit: gi|294502715|ref|YP_003566777.1| DNA primase 637382002078 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 637382002079 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 637382002080 active site 637382002081 metal binding site [ion binding]; metal-binding site 637382002082 interdomain interaction site; other site 637382002083 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 637382002084 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 637382002085 CHC2 zinc finger; Region: zf-CHC2; cl17510 637382002086 UGMP family protein; Validated; Region: PRK09604 637382002087 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 637382002088 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 637382002089 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 637382002090 homooctamer interface [polypeptide binding]; other site 637382002091 active site 637382002092 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 637382002093 potential frameshift: common BLAST hit: gi|294502720|ref|YP_003566782.1| tRNA nucleotidyltransferase 637382002094 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 637382002095 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 637382002096 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 637382002097 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637382002098 Zn2+ binding site [ion binding]; other site 637382002099 Mg2+ binding site [ion binding]; other site 637382002100 SH3 domain-containing protein; Provisional; Region: PRK10884 637382002101 Bacterial SH3 domain homologues; Region: SH3b; smart00287 637382002102 Uncharacterized conserved protein [Function unknown]; Region: COG3025 637382002103 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 637382002104 putative active site [active] 637382002105 putative metal binding residues [ion binding]; other site 637382002106 signature motif; other site 637382002107 putative triphosphate binding site [ion binding]; other site 637382002108 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 637382002109 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 637382002110 metal binding triad; other site 637382002111 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 637382002112 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 637382002113 metal binding triad; other site 637382002114 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 637382002115 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 637382002116 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 637382002117 putative ribose interaction site [chemical binding]; other site 637382002118 putative ADP binding site [chemical binding]; other site 637382002119 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 637382002120 active site 637382002121 nucleotide binding site [chemical binding]; other site 637382002122 HIGH motif; other site 637382002123 KMSKS motif; other site 637382002124 putative transporter; Provisional; Region: PRK11021 637382002125 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 637382002126 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 637382002127 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 637382002128 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 637382002129 putative active site [active] 637382002130 metal binding site [ion binding]; metal-binding site 637382002131 potential frameshift: common BLAST hit: gi|186896842|ref|YP_001873954.1| glutathionylspermidine synthase 637382002132 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 637382002133 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 637382002134 hypothetical protein; Provisional; Region: PRK11653 637382002135 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 637382002136 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 637382002137 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 637382002138 dimer interface [polypeptide binding]; other site 637382002139 ADP-ribose binding site [chemical binding]; other site 637382002140 active site 637382002141 nudix motif; other site 637382002142 metal binding site [ion binding]; metal-binding site 637382002143 putative dehydrogenase; Provisional; Region: PRK11039 637382002144 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 637382002145 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637382002146 active site 637382002147 metal binding site [ion binding]; metal-binding site 637382002148 hexamer interface [polypeptide binding]; other site 637382002149 esterase YqiA; Provisional; Region: PRK11071 637382002150 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637382002151 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 637382002152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382002153 ATP binding site [chemical binding]; other site 637382002154 Mg2+ binding site [ion binding]; other site 637382002155 G-X-G motif; other site 637382002156 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 637382002157 anchoring element; other site 637382002158 dimer interface [polypeptide binding]; other site 637382002159 ATP binding site [chemical binding]; other site 637382002160 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 637382002161 active site 637382002162 metal binding site [ion binding]; metal-binding site 637382002163 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 637382002164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382002165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382002166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637382002167 dimerization interface [polypeptide binding]; other site 637382002168 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 637382002169 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 637382002170 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 637382002171 CAP-like domain; other site 637382002172 active site 637382002173 primary dimer interface [polypeptide binding]; other site 637382002174 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637382002175 putative acyl-acceptor binding pocket; other site 637382002176 FtsI repressor; Provisional; Region: PRK10883 637382002177 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 637382002178 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 637382002179 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 637382002180 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 637382002181 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637382002182 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637382002183 active site 637382002184 catalytic tetrad [active] 637382002185 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 637382002186 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 637382002187 dimer interface [polypeptide binding]; other site 637382002188 active site 637382002189 metal binding site [ion binding]; metal-binding site 637382002190 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 637382002191 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382002192 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637382002193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382002194 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637382002195 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 637382002196 cystathionine beta-lyase; Provisional; Region: PRK08114 637382002197 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637382002198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382002199 catalytic residue [active] 637382002200 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 637382002201 biopolymer transport protein ExbD; Provisional; Region: PRK11267 637382002202 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 637382002203 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 637382002204 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 637382002205 metal ion-dependent adhesion site (MIDAS); other site 637382002206 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 637382002207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 637382002208 binding surface 637382002209 TPR motif; other site 637382002210 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 637382002211 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 637382002212 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637382002213 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 637382002214 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 637382002215 ATP binding site [chemical binding]; other site 637382002216 Walker A motif; other site 637382002217 hexamer interface [polypeptide binding]; other site 637382002218 Walker B motif; other site 637382002219 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 637382002220 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 637382002221 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 637382002222 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 637382002223 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 637382002224 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 637382002225 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 637382002226 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382002227 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382002228 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 637382002229 PapC N-terminal domain; Region: PapC_N; pfam13954 637382002230 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382002231 PapC C-terminal domain; Region: PapC_C; pfam13953 637382002232 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637382002233 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382002234 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637382002235 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637382002236 ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592 637382002237 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 637382002238 siderophore binding site; other site 637382002239 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 637382002240 potential frameshift: common BLAST hit: gi|162419744|ref|YP_001604865.1| flagellar biosynthesis protein FlhA 637382002241 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 637382002242 FHIPEP family; Region: FHIPEP; pfam00771 637382002243 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 637382002244 FHIPEP family; Region: FHIPEP; pfam00771 637382002245 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 637382002246 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 637382002247 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 637382002248 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 637382002249 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 637382002250 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 637382002251 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 637382002252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382002253 Walker A motif; other site 637382002254 ATP binding site [chemical binding]; other site 637382002255 Walker B motif; other site 637382002256 arginine finger; other site 637382002257 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 637382002258 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 637382002259 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 637382002260 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 637382002261 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 637382002262 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 637382002263 MgtE intracellular N domain; Region: MgtE_N; smart00924 637382002264 FliG C-terminal domain; Region: FliG_C; pfam01706 637382002265 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 637382002266 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 637382002267 Flagellar assembly protein FliH; Region: FliH; pfam02108 637382002268 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 637382002269 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637382002270 Walker A motif; other site 637382002271 ATP binding site [chemical binding]; other site 637382002272 Walker B motif; other site 637382002273 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 637382002274 FlgN protein; Region: FlgN; pfam05130 637382002275 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 637382002276 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 637382002277 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 637382002278 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 637382002279 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 637382002280 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 637382002281 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637382002282 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619 637382002283 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 637382002284 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 637382002285 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 637382002286 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637382002287 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 637382002288 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 637382002289 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637382002290 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382002291 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 637382002292 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 637382002293 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 637382002294 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637382002295 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637382002296 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 637382002297 Flagellar L-ring protein; Region: FlgH; pfam02107 637382002298 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 637382002299 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 637382002300 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 637382002301 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637382002302 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637382002303 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 637382002304 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637382002305 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637382002306 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382002307 DNA binding site [nucleotide binding] 637382002308 flagellin; Validated; Region: PRK06819 637382002309 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637382002310 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 637382002311 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637382002312 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 637382002313 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637382002314 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 637382002315 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 637382002316 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 637382002317 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 637382002318 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 637382002319 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637382002320 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 637382002321 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 637382002322 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 637382002323 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637382002324 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637382002325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637382002326 DNA binding residues [nucleotide binding] 637382002327 flagellar motor protein MotA; Provisional; Region: PRK12482 637382002328 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 637382002329 hypothetical protein; Validated; Region: PRK06778 637382002330 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 637382002331 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637382002332 ligand binding site [chemical binding]; other site 637382002333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637382002334 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382002335 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382002336 HTH-like domain; Region: HTH_21; pfam13276 637382002337 Integrase core domain; Region: rve; pfam00665 637382002338 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 637382002339 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637382002340 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382002341 DNA binding site [nucleotide binding] 637382002342 domain linker motif; other site 637382002343 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637382002344 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 637382002345 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 637382002346 transmembrane helices; other site 637382002347 hypothetical protein; Provisional; Region: PRK10039 637382002348 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637382002349 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637382002350 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637382002351 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637382002352 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637382002353 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637382002354 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637382002355 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637382002356 RHS Repeat; Region: RHS_repeat; pfam05593 637382002357 RHS Repeat; Region: RHS_repeat; cl11982 637382002358 RHS protein; Region: RHS; pfam03527 637382002359 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637382002360 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 637382002361 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637382002362 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 637382002363 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 637382002364 potential frameshift: common BLAST hit: gi|294502844|ref|YP_003566906.1| virG protein 637382002365 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 637382002366 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637382002367 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637382002368 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 637382002369 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637382002370 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637382002371 Autotransporter beta-domain; Region: Autotransporter; smart00869 637382002372 fructuronate transporter; Provisional; Region: PRK10034 637382002373 gluconate transporter; Region: gntP; TIGR00791 637382002374 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637382002375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637382002376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382002377 Walker A/P-loop; other site 637382002378 ATP binding site [chemical binding]; other site 637382002379 Q-loop/lid; other site 637382002380 ABC transporter signature motif; other site 637382002381 Walker B; other site 637382002382 D-loop; other site 637382002383 H-loop/switch region; other site 637382002384 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637382002385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637382002386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382002387 Walker A/P-loop; other site 637382002388 ATP binding site [chemical binding]; other site 637382002389 Q-loop/lid; other site 637382002390 ABC transporter signature motif; other site 637382002391 Walker B; other site 637382002392 D-loop; other site 637382002393 H-loop/switch region; other site 637382002394 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 637382002395 muropeptide transporter; Validated; Region: ampG; cl17669 637382002396 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 637382002397 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 637382002398 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637382002399 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 637382002400 Condensation domain; Region: Condensation; pfam00668 637382002401 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 637382002402 Nonribosomal peptide synthase; Region: NRPS; pfam08415 637382002403 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 637382002404 acyl-activating enzyme (AAE) consensus motif; other site 637382002405 AMP binding site [chemical binding]; other site 637382002406 Methyltransferase domain; Region: Methyltransf_31; pfam13847 637382002407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382002408 S-adenosylmethionine binding site [chemical binding]; other site 637382002409 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637382002410 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 637382002411 Thioesterase domain; Region: Thioesterase; pfam00975 637382002412 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 637382002413 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 637382002414 acyl-activating enzyme (AAE) consensus motif; other site 637382002415 AMP binding site [chemical binding]; other site 637382002416 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 637382002417 Condensation domain; Region: Condensation; pfam00668 637382002418 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 637382002419 Nonribosomal peptide synthase; Region: NRPS; pfam08415 637382002420 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 637382002421 acyl-activating enzyme (AAE) consensus motif; other site 637382002422 AMP binding site [chemical binding]; other site 637382002423 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637382002424 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 637382002425 Condensation domain; Region: Condensation; pfam00668 637382002426 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 637382002427 Nonribosomal peptide synthase; Region: NRPS; pfam08415 637382002428 transposase/IS protein; Provisional; Region: PRK09183 637382002429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382002430 Walker A motif; other site 637382002431 ATP binding site [chemical binding]; other site 637382002432 Walker B motif; other site 637382002433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382002434 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382002435 DNA-binding interface [nucleotide binding]; DNA binding site 637382002436 Integrase core domain; Region: rve; pfam00665 637382002437 acyl-CoA synthetase; Validated; Region: PRK05850 637382002438 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 637382002439 acyl-activating enzyme (AAE) consensus motif; other site 637382002440 active site 637382002441 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 637382002442 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 637382002443 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 637382002444 active site 637382002445 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 637382002446 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637382002447 N-terminal plug; other site 637382002448 ligand-binding site [chemical binding]; other site 637382002449 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 637382002450 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 637382002451 metal binding site [ion binding]; metal-binding site 637382002452 dimer interface [polypeptide binding]; other site 637382002453 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 637382002454 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 637382002455 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 637382002456 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 637382002457 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 637382002458 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 637382002459 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 637382002460 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 637382002461 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637382002462 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637382002463 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637382002464 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 637382002465 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 637382002466 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 637382002467 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382002468 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 637382002469 PAS domain S-box; Region: sensory_box; TIGR00229 637382002470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637382002471 putative active site [active] 637382002472 heme pocket [chemical binding]; other site 637382002473 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637382002474 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637382002475 metal binding site [ion binding]; metal-binding site 637382002476 active site 637382002477 I-site; other site 637382002478 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637382002479 putative transposase OrfB; Reviewed; Region: PHA02517 637382002480 HTH-like domain; Region: HTH_21; pfam13276 637382002481 Integrase core domain; Region: rve; pfam00665 637382002482 Integrase core domain; Region: rve_2; pfam13333 637382002483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637382002484 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382002485 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382002486 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 637382002487 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 637382002488 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 637382002489 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637382002490 N-terminal plug; other site 637382002491 ligand-binding site [chemical binding]; other site 637382002492 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 637382002493 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637382002494 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 637382002495 IucA / IucC family; Region: IucA_IucC; pfam04183 637382002496 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 637382002497 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 637382002498 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 637382002499 IucA / IucC family; Region: IucA_IucC; pfam04183 637382002500 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 637382002501 IucA / IucC family; Region: IucA_IucC; pfam04183 637382002502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637382002503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382002504 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 637382002505 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 637382002506 putative active site [active] 637382002507 Predicted peptidase [General function prediction only]; Region: COG4099 637382002508 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637382002509 Autoinducer binding domain; Region: Autoind_bind; pfam03472 637382002510 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382002511 DNA binding residues [nucleotide binding] 637382002512 dimerization interface [polypeptide binding]; other site 637382002513 Autoinducer synthetase; Region: Autoind_synth; cl17404 637382002514 CAAX protease self-immunity; Region: Abi; pfam02517 637382002515 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 637382002516 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 637382002517 Protein of unknown function (DUF877); Region: DUF877; pfam05943 637382002518 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 637382002519 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 637382002520 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 637382002521 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 637382002522 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637382002523 ligand binding site [chemical binding]; other site 637382002524 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 637382002525 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 637382002526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382002527 Walker A motif; other site 637382002528 ATP binding site [chemical binding]; other site 637382002529 Walker B motif; other site 637382002530 arginine finger; other site 637382002531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382002532 Walker A motif; other site 637382002533 ATP binding site [chemical binding]; other site 637382002534 Walker B motif; other site 637382002535 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637382002536 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 637382002537 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637382002538 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 637382002539 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 637382002540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 637382002541 Peptidase family M23; Region: Peptidase_M23; pfam01551 637382002542 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 637382002543 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 637382002544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 637382002545 ornithine decarboxylase; Provisional; Region: PRK13578 637382002546 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 637382002547 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 637382002548 homodimer interface [polypeptide binding]; other site 637382002549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382002550 catalytic residue [active] 637382002551 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 637382002552 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 637382002553 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 637382002554 putative ligand binding site [chemical binding]; other site 637382002555 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637382002556 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382002557 Walker A/P-loop; other site 637382002558 ATP binding site [chemical binding]; other site 637382002559 Q-loop/lid; other site 637382002560 ABC transporter signature motif; other site 637382002561 Walker B; other site 637382002562 D-loop; other site 637382002563 H-loop/switch region; other site 637382002564 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382002565 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382002566 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382002567 TM-ABC transporter signature motif; other site 637382002568 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 637382002569 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637382002570 N-terminal plug; other site 637382002571 ligand-binding site [chemical binding]; other site 637382002572 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 637382002573 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 637382002574 putative ligand binding residues [chemical binding]; other site 637382002575 murein transglycosylase C; Provisional; Region: mltC; PRK11671 637382002576 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 637382002577 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637382002578 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637382002579 catalytic residue [active] 637382002580 adenine DNA glycosylase; Provisional; Region: PRK10880 637382002581 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637382002582 minor groove reading motif; other site 637382002583 helix-hairpin-helix signature motif; other site 637382002584 substrate binding pocket [chemical binding]; other site 637382002585 active site 637382002586 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 637382002587 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 637382002588 DNA binding and oxoG recognition site [nucleotide binding] 637382002589 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 637382002590 hypothetical protein; Provisional; Region: PRK11702 637382002591 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 637382002592 glutaminase; Provisional; Region: PRK00971 637382002593 hypothetical protein; Provisional; Region: PRK10626 637382002594 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 637382002595 Peptidase C80 family; Region: Peptidase_C80; pfam11713 637382002596 Peptidase C80 family; Region: Peptidase_C80; pfam11713 637382002597 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 637382002598 HemN family oxidoreductase; Provisional; Region: PRK05660 637382002599 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382002600 FeS/SAM binding site; other site 637382002601 HemN C-terminal domain; Region: HemN_C; pfam06969 637382002602 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 637382002603 active site 637382002604 dimerization interface [polypeptide binding]; other site 637382002605 hypothetical protein; Validated; Region: PRK05090 637382002606 YGGT family; Region: YGGT; pfam02325 637382002607 Predicted integral membrane protein [Function unknown]; Region: COG0762 637382002608 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 637382002609 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 637382002610 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 637382002611 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637382002612 catalytic residue [active] 637382002613 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 637382002614 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 637382002615 Walker A motif; other site 637382002616 ATP binding site [chemical binding]; other site 637382002617 Walker B motif; other site 637382002618 agmatine deiminase; Provisional; Region: PRK13551 637382002619 agmatine deiminase; Region: agmatine_aguA; TIGR03380 637382002620 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 637382002621 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 637382002622 putative active site; other site 637382002623 catalytic triad [active] 637382002624 putative dimer interface [polypeptide binding]; other site 637382002625 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 637382002626 hypothetical protein; Validated; Region: PRK00228 637382002627 glutathione synthetase; Provisional; Region: PRK05246 637382002628 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 637382002629 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 637382002630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 637382002631 RNA methyltransferase, RsmE family; Region: TIGR00046 637382002632 DNA-specific endonuclease I; Provisional; Region: PRK15137 637382002633 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 637382002634 hypothetical protein; Provisional; Region: PRK04860 637382002635 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 637382002636 S-adenosylmethionine synthetase; Validated; Region: PRK05250 637382002637 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 637382002638 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 637382002639 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 637382002640 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 637382002641 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 637382002642 dimer interface [polypeptide binding]; other site 637382002643 active site 637382002644 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637382002645 catalytic residues [active] 637382002646 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 637382002647 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 637382002648 [2Fe-2S] cluster binding site [ion binding]; other site 637382002649 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 637382002650 transketolase; Reviewed; Region: PRK12753 637382002651 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637382002652 TPP-binding site [chemical binding]; other site 637382002653 dimer interface [polypeptide binding]; other site 637382002654 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637382002655 PYR/PP interface [polypeptide binding]; other site 637382002656 dimer interface [polypeptide binding]; other site 637382002657 TPP binding site [chemical binding]; other site 637382002658 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637382002659 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382002660 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 637382002661 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 637382002662 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 637382002663 Phosphoglycerate kinase; Region: PGK; pfam00162 637382002664 substrate binding site [chemical binding]; other site 637382002665 hinge regions; other site 637382002666 ADP binding site [chemical binding]; other site 637382002667 catalytic site [active] 637382002668 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 637382002669 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 637382002670 active site 637382002671 intersubunit interface [polypeptide binding]; other site 637382002672 zinc binding site [ion binding]; other site 637382002673 Na+ binding site [ion binding]; other site 637382002674 mechanosensitive channel MscS; Provisional; Region: PRK10334 637382002675 Conserved TM helix; Region: TM_helix; pfam05552 637382002676 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637382002677 arginine exporter protein; Provisional; Region: PRK09304 637382002678 Uncharacterized conserved protein [Function unknown]; Region: COG2968 637382002679 oxidative stress defense protein; Provisional; Region: PRK11087 637382002680 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 637382002681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382002682 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 637382002683 putative dimerization interface [polypeptide binding]; other site 637382002684 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 637382002685 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637382002686 active site 637382002687 dimer interface [polypeptide binding]; other site 637382002688 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 637382002689 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 637382002690 ligand binding site [chemical binding]; other site 637382002691 NAD binding site [chemical binding]; other site 637382002692 tetramer interface [polypeptide binding]; other site 637382002693 catalytic site [active] 637382002694 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 637382002695 L-serine binding site [chemical binding]; other site 637382002696 ACT domain interface; other site 637382002697 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 637382002698 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 637382002699 Z-ring-associated protein; Provisional; Region: PRK10972 637382002700 hypothetical protein; Reviewed; Region: PRK01736 637382002701 proline aminopeptidase P II; Provisional; Region: PRK10879 637382002702 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 637382002703 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 637382002704 active site 637382002705 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 637382002706 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 637382002707 oxidoreductase; Provisional; Region: PRK08013 637382002708 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 637382002709 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 637382002710 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 637382002711 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 637382002712 lipoyl attachment site [posttranslational modification]; other site 637382002713 glycine dehydrogenase; Provisional; Region: PRK05367 637382002714 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 637382002715 tetramer interface [polypeptide binding]; other site 637382002716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382002717 catalytic residue [active] 637382002718 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 637382002719 tetramer interface [polypeptide binding]; other site 637382002720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382002721 catalytic residue [active] 637382002722 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 637382002723 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 637382002724 YadA-like C-terminal region; Region: YadA; pfam03895 637382002725 hemolysin; Provisional; Region: PRK15087 637382002726 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 637382002727 Predicted small integral membrane protein [Function unknown]; Region: COG5472 637382002728 putative global regulator; Reviewed; Region: PRK09559 637382002729 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 637382002730 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 637382002731 DNA-binding response regulator CreB; Provisional; Region: PRK11083 637382002732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382002733 active site 637382002734 phosphorylation site [posttranslational modification] 637382002735 intermolecular recognition site; other site 637382002736 dimerization interface [polypeptide binding]; other site 637382002737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382002738 DNA binding site [nucleotide binding] 637382002739 sensory histidine kinase CreC; Provisional; Region: PRK11100 637382002740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382002741 dimer interface [polypeptide binding]; other site 637382002742 phosphorylation site [posttranslational modification] 637382002743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382002744 ATP binding site [chemical binding]; other site 637382002745 Mg2+ binding site [ion binding]; other site 637382002746 G-X-G motif; other site 637382002747 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 637382002748 flavodoxin FldB; Provisional; Region: PRK12359 637382002749 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 637382002750 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 637382002751 active site 637382002752 Int/Topo IB signature motif; other site 637382002753 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 637382002754 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 637382002755 dimerization domain [polypeptide binding]; other site 637382002756 dimer interface [polypeptide binding]; other site 637382002757 catalytic residues [active] 637382002758 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 637382002759 DHH family; Region: DHH; pfam01368 637382002760 DHHA1 domain; Region: DHHA1; pfam02272 637382002761 peptide chain release factor 2; Provisional; Region: PRK08787 637382002762 This domain is found in peptide chain release factors; Region: PCRF; smart00937 637382002763 RF-1 domain; Region: RF-1; pfam00472 637382002764 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 637382002765 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 637382002766 dimer interface [polypeptide binding]; other site 637382002767 putative anticodon binding site; other site 637382002768 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 637382002769 motif 1; other site 637382002770 active site 637382002771 motif 2; other site 637382002772 motif 3; other site 637382002773 integrase; Provisional; Region: PRK09692 637382002774 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 637382002775 active site 637382002776 Int/Topo IB signature motif; other site 637382002777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637382002778 non-specific DNA binding site [nucleotide binding]; other site 637382002779 salt bridge; other site 637382002780 sequence-specific DNA binding site [nucleotide binding]; other site 637382002781 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 637382002782 toxin interface [polypeptide binding]; other site 637382002783 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 637382002784 Zn binding site [ion binding]; other site 637382002785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637382002786 non-specific DNA binding site [nucleotide binding]; other site 637382002787 salt bridge; other site 637382002788 sequence-specific DNA binding site [nucleotide binding]; other site 637382002789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 637382002790 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 637382002791 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 637382002792 D5 N terminal like; Region: D5_N; smart00885 637382002793 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 637382002794 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 637382002795 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 637382002796 Fic family protein [Function unknown]; Region: COG3177 637382002797 Fic/DOC family; Region: Fic; pfam02661 637382002798 Pyocin large subunit [General function prediction only]; Region: COG5529 637382002799 S-type Pyocin; Region: Pyocin_S; pfam06958 637382002800 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 637382002801 PAAR motif; Region: PAAR_motif; pfam05488 637382002802 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 637382002803 Predicted transcriptional regulators [Transcription]; Region: COG1695 637382002804 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 637382002805 hypothetical protein; Provisional; Region: PRK11479 637382002806 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 637382002807 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 637382002808 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 637382002809 putative ligand binding site [chemical binding]; other site 637382002810 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382002811 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382002812 TM-ABC transporter signature motif; other site 637382002813 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637382002814 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382002815 Walker A/P-loop; other site 637382002816 ATP binding site [chemical binding]; other site 637382002817 Q-loop/lid; other site 637382002818 ABC transporter signature motif; other site 637382002819 Walker B; other site 637382002820 D-loop; other site 637382002821 H-loop/switch region; other site 637382002822 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382002823 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 637382002824 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 637382002825 Walker A/P-loop; other site 637382002826 ATP binding site [chemical binding]; other site 637382002827 Q-loop/lid; other site 637382002828 ABC transporter signature motif; other site 637382002829 Walker B; other site 637382002830 D-loop; other site 637382002831 H-loop/switch region; other site 637382002832 TOBE domain; Region: TOBE_2; pfam08402 637382002833 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 637382002834 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637382002835 DAK2 domain; Region: Dak2; cl03685 637382002836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382002837 dimer interface [polypeptide binding]; other site 637382002838 conserved gate region; other site 637382002839 ABC-ATPase subunit interface; other site 637382002840 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637382002841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382002842 dimer interface [polypeptide binding]; other site 637382002843 conserved gate region; other site 637382002844 putative PBP binding loops; other site 637382002845 ABC-ATPase subunit interface; other site 637382002846 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 637382002847 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 637382002848 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 637382002849 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 637382002850 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 637382002851 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637382002852 active site turn [active] 637382002853 phosphorylation site [posttranslational modification] 637382002854 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 637382002855 trimer interface; other site 637382002856 sugar binding site [chemical binding]; other site 637382002857 lac repressor; Reviewed; Region: lacI; PRK09526 637382002858 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382002859 DNA binding site [nucleotide binding] 637382002860 domain linker motif; other site 637382002861 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 637382002862 ligand binding site [chemical binding]; other site 637382002863 dimerization interface (open form) [polypeptide binding]; other site 637382002864 dimerization interface (closed form) [polypeptide binding]; other site 637382002865 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 637382002866 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 637382002867 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 637382002868 putative active site [active] 637382002869 putative catalytic site [active] 637382002870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382002871 D-galactonate transporter; Region: 2A0114; TIGR00893 637382002872 putative substrate translocation pore; other site 637382002873 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637382002874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382002875 DNA binding site [nucleotide binding] 637382002876 domain linker motif; other site 637382002877 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637382002878 dimerization interface [polypeptide binding]; other site 637382002879 ligand binding site [chemical binding]; other site 637382002880 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 637382002881 DJ-1 family protein; Region: not_thiJ; TIGR01383 637382002882 conserved cys residue [active] 637382002883 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 637382002884 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 637382002885 intersubunit interface [polypeptide binding]; other site 637382002886 active site 637382002887 zinc binding site [ion binding]; other site 637382002888 Na+ binding site [ion binding]; other site 637382002889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289 637382002890 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 637382002891 Sulfatase; Region: Sulfatase; pfam00884 637382002892 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 637382002893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382002894 FeS/SAM binding site; other site 637382002895 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 637382002896 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 637382002897 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481 637382002898 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 637382002899 NADP binding site [chemical binding]; other site 637382002900 homodimer interface [polypeptide binding]; other site 637382002901 active site 637382002902 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 637382002903 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 637382002904 active site 637382002905 dimer interface [polypeptide binding]; other site 637382002906 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 637382002907 active pocket/dimerization site; other site 637382002908 active site 637382002909 phosphorylation site [posttranslational modification] 637382002910 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 637382002911 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 637382002912 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 637382002913 active site 637382002914 phosphorylation site [posttranslational modification] 637382002915 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 637382002916 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 637382002917 dimer interface [polypeptide binding]; other site 637382002918 active site 637382002919 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 637382002920 putative active site [active] 637382002921 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 637382002922 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637382002923 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 637382002924 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637382002925 Sulfatase; Region: Sulfatase; cl17466 637382002926 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 637382002927 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382002928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382002929 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382002930 DNA-binding interface [nucleotide binding]; DNA binding site 637382002931 Integrase core domain; Region: rve; pfam00665 637382002932 transposase/IS protein; Provisional; Region: PRK09183 637382002933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382002934 Walker A motif; other site 637382002935 ATP binding site [chemical binding]; other site 637382002936 Walker B motif; other site 637382002937 Lyase, N terminal; Region: Lyase_N; pfam09092 637382002938 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 637382002939 substrate binding site [chemical binding]; other site 637382002940 catalytic residues [active] 637382002941 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637382002942 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 637382002943 active site clefts [active] 637382002944 zinc binding site [ion binding]; other site 637382002945 dimer interface [polypeptide binding]; other site 637382002946 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 637382002947 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 637382002948 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 637382002949 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 637382002950 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 637382002951 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 637382002952 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 637382002953 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 637382002954 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 637382002955 Walker A motif; other site 637382002956 ATP binding site [chemical binding]; other site 637382002957 Walker B motif; other site 637382002958 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637382002959 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637382002960 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 637382002961 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 637382002962 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 637382002963 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 637382002964 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 637382002965 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 637382002966 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 637382002967 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 637382002968 GspL periplasmic domain; Region: GspL_C; pfam12693 637382002969 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 637382002970 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 637382002971 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 637382002972 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 637382002973 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 637382002974 DNA binding site [nucleotide binding] 637382002975 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 637382002976 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 637382002977 dimer interface [polypeptide binding]; other site 637382002978 ligand binding site [chemical binding]; other site 637382002979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382002980 dimerization interface [polypeptide binding]; other site 637382002981 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637382002982 dimer interface [polypeptide binding]; other site 637382002983 putative CheW interface [polypeptide binding]; other site 637382002984 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 637382002985 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 637382002986 catalytic residues [active] 637382002987 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 637382002988 transcriptional activator TtdR; Provisional; Region: PRK09801 637382002989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382002990 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 637382002991 putative effector binding pocket; other site 637382002992 dimerization interface [polypeptide binding]; other site 637382002993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382002994 putative substrate translocation pore; other site 637382002995 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637382002996 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 637382002997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382002998 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637382002999 dimerization interface [polypeptide binding]; other site 637382003000 diaminopimelate decarboxylase; Provisional; Region: PRK11165 637382003001 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 637382003002 active site 637382003003 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637382003004 substrate binding site [chemical binding]; other site 637382003005 catalytic residues [active] 637382003006 dimer interface [polypeptide binding]; other site 637382003007 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 637382003008 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382003009 DNA binding site [nucleotide binding] 637382003010 domain linker motif; other site 637382003011 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 637382003012 dimerization interface (closed form) [polypeptide binding]; other site 637382003013 ligand binding site [chemical binding]; other site 637382003014 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 637382003015 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 637382003016 molybdopterin cofactor binding site [chemical binding]; other site 637382003017 substrate binding site [chemical binding]; other site 637382003018 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 637382003019 molybdopterin cofactor binding site; other site 637382003020 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 637382003021 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637382003022 putative acyl-acceptor binding pocket; other site 637382003023 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 637382003024 acyl-activating enzyme (AAE) consensus motif; other site 637382003025 putative AMP binding site [chemical binding]; other site 637382003026 lysophospholipid transporter LplT; Provisional; Region: PRK11195 637382003027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382003028 putative substrate translocation pore; other site 637382003029 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637382003030 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637382003031 active site 637382003032 catalytic tetrad [active] 637382003033 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 637382003034 putative DNA clevage site; other site 637382003035 putative DNA-binding cleft [nucleotide binding]; other site 637382003036 molecular lever; other site 637382003037 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 637382003038 putative active site [active] 637382003039 Ap4A binding site [chemical binding]; other site 637382003040 nudix motif; other site 637382003041 putative metal binding site [ion binding]; other site 637382003042 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 637382003043 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 637382003044 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 637382003045 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 637382003046 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 637382003047 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 637382003048 thymidylate synthase; Reviewed; Region: thyA; PRK01827 637382003049 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 637382003050 dimerization interface [polypeptide binding]; other site 637382003051 active site 637382003052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382003053 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382003054 DNA-binding interface [nucleotide binding]; DNA binding site 637382003055 Integrase core domain; Region: rve; pfam00665 637382003056 transposase/IS protein; Provisional; Region: PRK09183 637382003057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382003058 Walker A motif; other site 637382003059 ATP binding site [chemical binding]; other site 637382003060 Walker B motif; other site 637382003061 hypothetical protein; Provisional; Region: PRK10557 637382003062 Protein of unknown function (DUF2509); Region: DUF2509; pfam10713 637382003063 hypothetical protein; Provisional; Region: PRK10332 637382003064 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 637382003065 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 637382003066 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 637382003067 protease3; Provisional; Region: PRK15101 637382003068 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 637382003069 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637382003070 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637382003071 potential frameshift: common BLAST hit: gi|294503038|ref|YP_003567100.1| exodeoxyribonuclease V subunit beta 637382003072 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 637382003073 Family description; Region: UvrD_C_2; pfam13538 637382003074 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 637382003075 AAA domain; Region: AAA_30; pfam13604 637382003076 Family description; Region: UvrD_C_2; pfam13538 637382003077 N-acetylglutamate synthase; Validated; Region: PRK05279 637382003078 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 637382003079 putative feedback inhibition sensing region; other site 637382003080 putative nucleotide binding site [chemical binding]; other site 637382003081 putative substrate binding site [chemical binding]; other site 637382003082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637382003083 Coenzyme A binding pocket [chemical binding]; other site 637382003084 AMIN domain; Region: AMIN; pfam11741 637382003085 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 637382003086 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637382003087 active site 637382003088 metal binding site [ion binding]; metal-binding site 637382003089 murein transglycosylase A; Provisional; Region: mltA; PRK11162 637382003090 MltA specific insert domain; Region: MltA; smart00925 637382003091 3D domain; Region: 3D; pfam06725 637382003092 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 637382003093 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 637382003094 putative ATP binding site [chemical binding]; other site 637382003095 putative substrate interface [chemical binding]; other site 637382003096 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 637382003097 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637382003098 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 637382003099 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382003100 catalytic residue [active] 637382003101 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 637382003102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382003103 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 637382003104 dimerization interface [polypeptide binding]; other site 637382003105 substrate binding pocket [chemical binding]; other site 637382003106 hypothetical protein; Provisional; Region: PRK10873 637382003107 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 637382003108 FtsJ-like methyltransferase; Region: FtsJ; cl17430 637382003109 flap endonuclease-like protein; Provisional; Region: PRK09482 637382003110 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 637382003111 active site 637382003112 metal binding site 1 [ion binding]; metal-binding site 637382003113 putative 5' ssDNA interaction site; other site 637382003114 metal binding site 3; metal-binding site 637382003115 metal binding site 2 [ion binding]; metal-binding site 637382003116 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 637382003117 putative DNA binding site [nucleotide binding]; other site 637382003118 putative metal binding site [ion binding]; other site 637382003119 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 637382003120 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 637382003121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 637382003122 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 637382003123 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 637382003124 SecY interacting protein Syd; Provisional; Region: PRK04968 637382003125 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382003126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 637382003127 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637382003128 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 637382003129 probable active site [active] 637382003130 flavodoxin; Provisional; Region: PRK08105 637382003131 hypothetical protein; Provisional; Region: PRK13677 637382003132 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 637382003133 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 637382003134 trimer interface [polypeptide binding]; other site 637382003135 active site 637382003136 substrate binding site [chemical binding]; other site 637382003137 CoA binding site [chemical binding]; other site 637382003138 PII uridylyl-transferase; Provisional; Region: PRK05007 637382003139 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 637382003140 metal binding triad; other site 637382003141 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 637382003142 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 637382003143 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 637382003144 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 637382003145 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 637382003146 active site 637382003147 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 637382003148 rRNA interaction site [nucleotide binding]; other site 637382003149 S8 interaction site; other site 637382003150 putative laminin-1 binding site; other site 637382003151 potential frameshift: common BLAST hit: gi|294503062|ref|YP_003567124.1| elongation factor Ts 637382003152 UBA/TS-N domain; Region: UBA; pfam00627 637382003153 Elongation factor TS; Region: EF_TS; pfam00889 637382003154 Elongation factor TS; Region: EF_TS; pfam00889 637382003155 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 637382003156 putative nucleotide binding site [chemical binding]; other site 637382003157 uridine monophosphate binding site [chemical binding]; other site 637382003158 homohexameric interface [polypeptide binding]; other site 637382003159 ribosome recycling factor; Reviewed; Region: frr; PRK00083 637382003160 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 637382003161 hinge region; other site 637382003162 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 637382003163 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 637382003164 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 637382003165 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 637382003166 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 637382003167 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 637382003168 catalytic residue [active] 637382003169 putative FPP diphosphate binding site; other site 637382003170 putative FPP binding hydrophobic cleft; other site 637382003171 dimer interface [polypeptide binding]; other site 637382003172 putative IPP diphosphate binding site; other site 637382003173 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 637382003174 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 637382003175 zinc metallopeptidase RseP; Provisional; Region: PRK10779 637382003176 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 637382003177 active site 637382003178 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 637382003179 protein binding site [polypeptide binding]; other site 637382003180 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 637382003181 protein binding site [polypeptide binding]; other site 637382003182 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 637382003183 putative substrate binding region [chemical binding]; other site 637382003184 potential frameshift: common BLAST hit: gi|294503069|ref|YP_003567131.1| putative surface antigen 637382003185 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 637382003186 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 637382003187 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 637382003188 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 637382003189 Surface antigen; Region: Bac_surface_Ag; pfam01103 637382003190 periplasmic chaperone; Provisional; Region: PRK10780 637382003191 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637382003192 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 637382003193 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 637382003194 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 637382003195 trimer interface [polypeptide binding]; other site 637382003196 active site 637382003197 UDP-GlcNAc binding site [chemical binding]; other site 637382003198 lipid binding site [chemical binding]; lipid-binding site 637382003199 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 637382003200 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 637382003201 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 637382003202 active site 637382003203 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 637382003204 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 637382003205 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 637382003206 RNA/DNA hybrid binding site [nucleotide binding]; other site 637382003207 active site 637382003208 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 637382003209 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 637382003210 putative active site [active] 637382003211 putative PHP Thumb interface [polypeptide binding]; other site 637382003212 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 637382003213 generic binding surface II; other site 637382003214 generic binding surface I; other site 637382003215 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 637382003216 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 637382003217 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 637382003218 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 637382003219 putative metal binding site [ion binding]; other site 637382003220 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 637382003221 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 637382003222 Ligand Binding Site [chemical binding]; other site 637382003223 TilS substrate binding domain; Region: TilS; pfam09179 637382003224 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 637382003225 Cytochrome c553 [Energy production and conversion]; Region: COG2863 637382003226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 637382003227 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 637382003228 hypothetical protein; Provisional; Region: PRK09256 637382003229 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 637382003230 NlpE N-terminal domain; Region: NlpE; pfam04170 637382003231 prolyl-tRNA synthetase; Provisional; Region: PRK09194 637382003232 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 637382003233 dimer interface [polypeptide binding]; other site 637382003234 motif 1; other site 637382003235 active site 637382003236 motif 2; other site 637382003237 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 637382003238 putative deacylase active site [active] 637382003239 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637382003240 active site 637382003241 motif 3; other site 637382003242 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 637382003243 anticodon binding site; other site 637382003244 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 637382003245 homodimer interaction site [polypeptide binding]; other site 637382003246 cofactor binding site; other site 637382003247 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 637382003248 lipoprotein, YaeC family; Region: TIGR00363 637382003249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382003250 dimer interface [polypeptide binding]; other site 637382003251 conserved gate region; other site 637382003252 ABC-ATPase subunit interface; other site 637382003253 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637382003254 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 637382003255 Walker A/P-loop; other site 637382003256 ATP binding site [chemical binding]; other site 637382003257 Q-loop/lid; other site 637382003258 ABC transporter signature motif; other site 637382003259 Walker B; other site 637382003260 D-loop; other site 637382003261 H-loop/switch region; other site 637382003262 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 637382003263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382003264 active site 637382003265 motif I; other site 637382003266 motif II; other site 637382003267 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637382003268 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637382003269 active site 637382003270 catalytic tetrad [active] 637382003271 hypothetical protein; Provisional; Region: PRK05421 637382003272 putative catalytic site [active] 637382003273 putative phosphate binding site [ion binding]; other site 637382003274 putative metal binding site [ion binding]; other site 637382003275 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 637382003276 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637382003277 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637382003278 catalytic residue [active] 637382003279 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637382003280 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637382003281 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 637382003282 Methyltransferase domain; Region: Methyltransf_11; pfam08241 637382003283 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 637382003284 RNA/DNA hybrid binding site [nucleotide binding]; other site 637382003285 active site 637382003286 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 637382003287 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 637382003288 active site 637382003289 catalytic site [active] 637382003290 substrate binding site [chemical binding]; other site 637382003291 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 637382003292 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 637382003293 Na binding site [ion binding]; other site 637382003294 putative substrate binding site [chemical binding]; other site 637382003295 transposase/IS protein; Provisional; Region: PRK09183 637382003296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382003297 Walker A motif; other site 637382003298 ATP binding site [chemical binding]; other site 637382003299 Walker B motif; other site 637382003300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382003301 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382003302 DNA-binding interface [nucleotide binding]; DNA binding site 637382003303 Integrase core domain; Region: rve; pfam00665 637382003304 AAA domain; Region: AAA_25; pfam13481 637382003305 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637382003306 Walker A motif; other site 637382003307 ATP binding site [chemical binding]; other site 637382003308 Walker B motif; other site 637382003309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 637382003310 Toprim domain; Region: Toprim_3; pfam13362 637382003311 active site 637382003312 metal binding site [ion binding]; metal-binding site 637382003313 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 637382003314 Integrase; Region: Integrase_1; pfam12835 637382003315 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 637382003316 integrase; Provisional; Region: PRK09692 637382003317 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 637382003318 active site 637382003319 Int/Topo IB signature motif; other site 637382003320 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382003321 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 637382003322 SmpB-tmRNA interface; other site 637382003323 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 637382003324 putative coenzyme Q binding site [chemical binding]; other site 637382003325 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 637382003326 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 637382003327 recombination and repair protein; Provisional; Region: PRK10869 637382003328 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 637382003329 Walker A/P-loop; other site 637382003330 ATP binding site [chemical binding]; other site 637382003331 Q-loop/lid; other site 637382003332 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 637382003333 Q-loop/lid; other site 637382003334 ABC transporter signature motif; other site 637382003335 Walker B; other site 637382003336 D-loop; other site 637382003337 H-loop/switch region; other site 637382003338 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 637382003339 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 637382003340 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 637382003341 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 637382003342 dimer interface [polypeptide binding]; other site 637382003343 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 637382003344 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 637382003345 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 637382003346 dimer interface [polypeptide binding]; other site 637382003347 active site 637382003348 citrylCoA binding site [chemical binding]; other site 637382003349 NADH binding [chemical binding]; other site 637382003350 cationic pore residues; other site 637382003351 oxalacetate/citrate binding site [chemical binding]; other site 637382003352 coenzyme A binding site [chemical binding]; other site 637382003353 catalytic triad [active] 637382003354 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 637382003355 SdhC subunit interface [polypeptide binding]; other site 637382003356 proximal heme binding site [chemical binding]; other site 637382003357 cardiolipin binding site; other site 637382003358 Iron-sulfur protein interface; other site 637382003359 proximal quinone binding site [chemical binding]; other site 637382003360 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 637382003361 L-aspartate oxidase; Provisional; Region: PRK06175 637382003362 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 637382003363 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 637382003364 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 637382003365 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 637382003366 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 637382003367 TPP-binding site [chemical binding]; other site 637382003368 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 637382003369 dimer interface [polypeptide binding]; other site 637382003370 PYR/PP interface [polypeptide binding]; other site 637382003371 TPP binding site [chemical binding]; other site 637382003372 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 637382003373 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637382003374 E3 interaction surface; other site 637382003375 lipoyl attachment site [posttranslational modification]; other site 637382003376 e3 binding domain; Region: E3_binding; pfam02817 637382003377 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 637382003378 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 637382003379 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 637382003380 CoA-ligase; Region: Ligase_CoA; pfam00549 637382003381 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 637382003382 CoA binding domain; Region: CoA_binding; smart00881 637382003383 CoA-ligase; Region: Ligase_CoA; pfam00549 637382003384 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 637382003385 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 637382003386 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 637382003387 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 637382003388 colicin uptake protein TolQ; Provisional; Region: PRK10801 637382003389 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 637382003390 colicin uptake protein TolR; Provisional; Region: PRK11024 637382003391 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 637382003392 TolA C-terminal; Region: TolA; pfam06519 637382003393 translocation protein TolB; Provisional; Region: tolB; PRK03629 637382003394 TolB amino-terminal domain; Region: TolB_N; pfam04052 637382003395 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 637382003396 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 637382003397 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 637382003398 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 637382003399 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637382003400 ligand binding site [chemical binding]; other site 637382003401 tol-pal system protein YbgF; Provisional; Region: PRK10803 637382003402 Tetratricopeptide repeat; Region: TPR_6; pfam13174 637382003403 quinolinate synthetase; Provisional; Region: PRK09375 637382003404 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 637382003405 Cation efflux family; Region: Cation_efflux; cl00316 637382003406 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 637382003407 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 637382003408 transposase/IS protein; Provisional; Region: PRK09183 637382003409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382003410 Walker A motif; other site 637382003411 ATP binding site [chemical binding]; other site 637382003412 Walker B motif; other site 637382003413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382003414 Integrase core domain; Region: rve; pfam00665 637382003415 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637382003416 catalytic core [active] 637382003417 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637382003418 psiF repeat; Region: PsiF_repeat; pfam07769 637382003419 psiF repeat; Region: PsiF_repeat; pfam07769 637382003420 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 637382003421 active site 637382003422 catalytic residues [active] 637382003423 galactokinase; Provisional; Region: PRK05101 637382003424 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 637382003425 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637382003426 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 637382003427 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 637382003428 dimer interface [polypeptide binding]; other site 637382003429 active site 637382003430 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 637382003431 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 637382003432 NAD binding site [chemical binding]; other site 637382003433 homodimer interface [polypeptide binding]; other site 637382003434 active site 637382003435 substrate binding site [chemical binding]; other site 637382003436 CAAX protease self-immunity; Region: Abi; pfam02517 637382003437 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 637382003438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382003439 Walker A/P-loop; other site 637382003440 ATP binding site [chemical binding]; other site 637382003441 ABC transporter signature motif; other site 637382003442 Walker B; other site 637382003443 D-loop; other site 637382003444 H-loop/switch region; other site 637382003445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382003446 Walker A/P-loop; other site 637382003447 ATP binding site [chemical binding]; other site 637382003448 Q-loop/lid; other site 637382003449 ABC transporter signature motif; other site 637382003450 Walker B; other site 637382003451 D-loop; other site 637382003452 H-loop/switch region; other site 637382003453 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 637382003454 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 637382003455 molybdenum-pterin binding domain; Region: Mop; TIGR00638 637382003456 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 637382003457 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 637382003458 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 637382003459 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 637382003460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382003461 dimer interface [polypeptide binding]; other site 637382003462 conserved gate region; other site 637382003463 putative PBP binding loops; other site 637382003464 ABC-ATPase subunit interface; other site 637382003465 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 637382003466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382003467 Walker A/P-loop; other site 637382003468 ATP binding site [chemical binding]; other site 637382003469 Q-loop/lid; other site 637382003470 ABC transporter signature motif; other site 637382003471 Walker B; other site 637382003472 D-loop; other site 637382003473 H-loop/switch region; other site 637382003474 molybdenum-pterin binding domain; Region: Mop; TIGR00638 637382003475 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 637382003476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382003477 active site 637382003478 motif I; other site 637382003479 motif II; other site 637382003480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382003481 6-phosphogluconolactonase; Provisional; Region: PRK11028 637382003482 potential frameshift: common BLAST hit: gi|294503152|ref|YP_003567214.1| adenosylmethionine-8-amino-7-oxononanoate aminotransferase 637382003483 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637382003484 inhibitor-cofactor binding pocket; inhibition site 637382003485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382003486 catalytic residue [active] 637382003487 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637382003488 biotin synthase; Provisional; Region: PRK15108 637382003489 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382003490 FeS/SAM binding site; other site 637382003491 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 637382003492 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 637382003493 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 637382003494 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382003495 catalytic residue [active] 637382003496 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 637382003497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382003498 S-adenosylmethionine binding site [chemical binding]; other site 637382003499 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 637382003500 AAA domain; Region: AAA_26; pfam13500 637382003501 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 637382003502 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 637382003503 Walker A/P-loop; other site 637382003504 ATP binding site [chemical binding]; other site 637382003505 Q-loop/lid; other site 637382003506 ABC transporter signature motif; other site 637382003507 Walker B; other site 637382003508 D-loop; other site 637382003509 H-loop/switch region; other site 637382003510 excinuclease ABC subunit B; Provisional; Region: PRK05298 637382003511 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 637382003512 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637382003513 ATP-binding site [chemical binding]; other site 637382003514 ATP binding site [chemical binding]; other site 637382003515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382003516 nucleotide binding region [chemical binding]; other site 637382003517 ATP-binding site [chemical binding]; other site 637382003518 Ultra-violet resistance protein B; Region: UvrB; pfam12344 637382003519 UvrB/uvrC motif; Region: UVR; pfam02151 637382003520 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 637382003521 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 637382003522 phosphate binding site [ion binding]; other site 637382003523 putative substrate binding pocket [chemical binding]; other site 637382003524 dimer interface [polypeptide binding]; other site 637382003525 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 637382003526 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382003527 FeS/SAM binding site; other site 637382003528 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 637382003529 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 637382003530 trimer interface [polypeptide binding]; other site 637382003531 dimer interface [polypeptide binding]; other site 637382003532 putative active site [active] 637382003533 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 637382003534 MoaE homodimer interface [polypeptide binding]; other site 637382003535 MoaD interaction [polypeptide binding]; other site 637382003536 active site residues [active] 637382003537 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 637382003538 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 637382003539 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382003540 choline dehydrogenase; Validated; Region: PRK02106 637382003541 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 637382003542 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 637382003543 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 637382003544 NAD(P) binding site [chemical binding]; other site 637382003545 catalytic residues [active] 637382003546 transcriptional regulator BetI; Validated; Region: PRK00767 637382003547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637382003548 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 637382003549 choline transport protein BetT; Provisional; Region: PRK09928 637382003550 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 637382003551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382003552 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 637382003553 putative dimerization interface [polypeptide binding]; other site 637382003554 putative substrate binding pocket [chemical binding]; other site 637382003555 EamA-like transporter family; Region: EamA; pfam00892 637382003556 xanthosine phosphorylase; Region: XAPA; TIGR01699 637382003557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382003558 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382003559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382003560 zinc resistance protein; Provisional; Region: zraP; PRK11546 637382003561 dimer interface [polypeptide binding]; other site 637382003562 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 637382003563 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637382003564 putative active site [active] 637382003565 heme pocket [chemical binding]; other site 637382003566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382003567 dimer interface [polypeptide binding]; other site 637382003568 phosphorylation site [posttranslational modification] 637382003569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382003570 ATP binding site [chemical binding]; other site 637382003571 Mg2+ binding site [ion binding]; other site 637382003572 G-X-G motif; other site 637382003573 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 637382003574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382003575 active site 637382003576 phosphorylation site [posttranslational modification] 637382003577 intermolecular recognition site; other site 637382003578 dimerization interface [polypeptide binding]; other site 637382003579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382003580 Walker A motif; other site 637382003581 ATP binding site [chemical binding]; other site 637382003582 Walker B motif; other site 637382003583 arginine finger; other site 637382003584 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 637382003585 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 637382003586 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 637382003587 FMN binding site [chemical binding]; other site 637382003588 active site 637382003589 substrate binding site [chemical binding]; other site 637382003590 catalytic residue [active] 637382003591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382003592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382003593 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 637382003594 putative effector binding pocket; other site 637382003595 putative dimerization interface [polypeptide binding]; other site 637382003596 conserved hypothetical protein; Region: TIGR02118 637382003597 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 637382003598 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 637382003599 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 637382003600 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 637382003601 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637382003602 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637382003603 Walker A/P-loop; other site 637382003604 ATP binding site [chemical binding]; other site 637382003605 Q-loop/lid; other site 637382003606 ABC transporter signature motif; other site 637382003607 Walker B; other site 637382003608 D-loop; other site 637382003609 H-loop/switch region; other site 637382003610 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637382003611 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637382003612 Walker A/P-loop; other site 637382003613 ATP binding site [chemical binding]; other site 637382003614 Q-loop/lid; other site 637382003615 ABC transporter signature motif; other site 637382003616 Walker B; other site 637382003617 D-loop; other site 637382003618 H-loop/switch region; other site 637382003619 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 637382003620 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382003621 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382003622 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 637382003623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637382003624 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 637382003625 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 637382003626 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 637382003627 ATP binding site [chemical binding]; other site 637382003628 Mg++ binding site [ion binding]; other site 637382003629 motif III; other site 637382003630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382003631 nucleotide binding region [chemical binding]; other site 637382003632 ATP-binding site [chemical binding]; other site 637382003633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382003634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382003635 MULE transposase domain; Region: MULE; pfam10551 637382003636 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637382003637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637382003638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 637382003639 putative Mg++ binding site [ion binding]; other site 637382003640 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382003641 nucleotide binding region [chemical binding]; other site 637382003642 ATP-binding site [chemical binding]; other site 637382003643 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382003644 Uncharacterized conserved protein [Function unknown]; Region: COG3595 637382003645 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 637382003646 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 637382003647 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 637382003648 FMN binding site [chemical binding]; other site 637382003649 active site 637382003650 catalytic residues [active] 637382003651 substrate binding site [chemical binding]; other site 637382003652 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 637382003653 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 637382003654 D-lactate dehydrogenase; Provisional; Region: PRK11183 637382003655 FAD binding domain; Region: FAD_binding_4; pfam01565 637382003656 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 637382003657 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 637382003658 putative active site [active] 637382003659 putative metal binding residues [ion binding]; other site 637382003660 signature motif; other site 637382003661 putative triphosphate binding site [ion binding]; other site 637382003662 dimer interface [polypeptide binding]; other site 637382003663 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 637382003664 active site 637382003665 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 637382003666 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 637382003667 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 637382003668 Walker A/P-loop; other site 637382003669 ATP binding site [chemical binding]; other site 637382003670 Q-loop/lid; other site 637382003671 ABC transporter signature motif; other site 637382003672 Walker B; other site 637382003673 D-loop; other site 637382003674 H-loop/switch region; other site 637382003675 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 637382003676 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 637382003677 Transferrin; Region: Transferrin; cl02460 637382003678 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 637382003679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382003680 dimer interface [polypeptide binding]; other site 637382003681 conserved gate region; other site 637382003682 putative PBP binding loops; other site 637382003683 ABC-ATPase subunit interface; other site 637382003684 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 637382003685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382003686 dimer interface [polypeptide binding]; other site 637382003687 conserved gate region; other site 637382003688 putative PBP binding loops; other site 637382003689 ABC-ATPase subunit interface; other site 637382003690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 637382003691 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 637382003692 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 637382003693 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 637382003694 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 637382003695 putative ligand binding site [chemical binding]; other site 637382003696 HEAT repeats; Region: HEAT_2; pfam13646 637382003697 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 637382003698 TM-ABC transporter signature motif; other site 637382003699 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 637382003700 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 637382003701 TM-ABC transporter signature motif; other site 637382003702 Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674 637382003703 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 637382003704 Walker A/P-loop; other site 637382003705 ATP binding site [chemical binding]; other site 637382003706 Q-loop/lid; other site 637382003707 ABC transporter signature motif; other site 637382003708 Walker B; other site 637382003709 D-loop; other site 637382003710 H-loop/switch region; other site 637382003711 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 637382003712 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 637382003713 Walker A/P-loop; other site 637382003714 ATP binding site [chemical binding]; other site 637382003715 Q-loop/lid; other site 637382003716 ABC transporter signature motif; other site 637382003717 Walker B; other site 637382003718 D-loop; other site 637382003719 H-loop/switch region; other site 637382003720 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 637382003721 tyrosine decarboxylase; Region: PLN02880 637382003722 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 637382003723 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382003724 catalytic residue [active] 637382003725 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 637382003726 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 637382003727 active site residue [active] 637382003728 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 637382003729 active site residue [active] 637382003730 potential frameshift: common BLAST hit: gi|186894644|ref|YP_001871756.1| glycine betaine ABC transporter substrate-binding protein 637382003731 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 637382003732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 637382003733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382003734 dimer interface [polypeptide binding]; other site 637382003735 conserved gate region; other site 637382003736 ABC-ATPase subunit interface; other site 637382003737 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 637382003738 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 637382003739 Walker A/P-loop; other site 637382003740 ATP binding site [chemical binding]; other site 637382003741 Q-loop/lid; other site 637382003742 ABC transporter signature motif; other site 637382003743 Walker B; other site 637382003744 D-loop; other site 637382003745 H-loop/switch region; other site 637382003746 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 637382003747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382003748 putative PBP binding loops; other site 637382003749 dimer interface [polypeptide binding]; other site 637382003750 ABC-ATPase subunit interface; other site 637382003751 arginine:agmatin antiporter; Provisional; Region: PRK10644 637382003752 arginine decarboxylase; Provisional; Region: PRK15029 637382003753 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 637382003754 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637382003755 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382003756 catalytic residue [active] 637382003757 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 637382003758 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 637382003759 EamA-like transporter family; Region: EamA; pfam00892 637382003760 EamA-like transporter family; Region: EamA; pfam00892 637382003761 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 637382003762 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 637382003763 trimer interface [polypeptide binding]; other site 637382003764 eyelet of channel; other site 637382003765 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 637382003766 DEAD_2; Region: DEAD_2; pfam06733 637382003767 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 637382003768 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 637382003769 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 637382003770 tetramer interface [polypeptide binding]; other site 637382003771 heme binding pocket [chemical binding]; other site 637382003772 NADPH binding site [chemical binding]; other site 637382003773 YfaZ precursor; Region: YfaZ; pfam07437 637382003774 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 637382003775 tyrosine transporter TyrP; Provisional; Region: PRK15132 637382003776 aromatic amino acid transport protein; Region: araaP; TIGR00837 637382003777 hypothetical protein; Provisional; Region: PRK03673 637382003778 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 637382003779 putative MPT binding site; other site 637382003780 Competence-damaged protein; Region: CinA; cl00666 637382003781 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 637382003782 secondary substrate binding site; other site 637382003783 primary substrate binding site; other site 637382003784 inhibition loop; other site 637382003785 dimerization interface [polypeptide binding]; other site 637382003786 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 637382003787 dimer interface [polypeptide binding]; other site 637382003788 putative radical transfer pathway; other site 637382003789 diiron center [ion binding]; other site 637382003790 tyrosyl radical; other site 637382003791 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 637382003792 ATP cone domain; Region: ATP-cone; pfam03477 637382003793 Class I ribonucleotide reductase; Region: RNR_I; cd01679 637382003794 active site 637382003795 dimer interface [polypeptide binding]; other site 637382003796 catalytic residues [active] 637382003797 effector binding site; other site 637382003798 R2 peptide binding site; other site 637382003799 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 637382003800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382003801 S-adenosylmethionine binding site [chemical binding]; other site 637382003802 DNA gyrase subunit A; Validated; Region: PRK05560 637382003803 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 637382003804 CAP-like domain; other site 637382003805 active site 637382003806 primary dimer interface [polypeptide binding]; other site 637382003807 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637382003808 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637382003809 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637382003810 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637382003811 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637382003812 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637382003813 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 637382003814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382003815 dimer interface [polypeptide binding]; other site 637382003816 phosphorylation site [posttranslational modification] 637382003817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382003818 ATP binding site [chemical binding]; other site 637382003819 Mg2+ binding site [ion binding]; other site 637382003820 G-X-G motif; other site 637382003821 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 637382003822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382003823 active site 637382003824 phosphorylation site [posttranslational modification] 637382003825 intermolecular recognition site; other site 637382003826 dimerization interface [polypeptide binding]; other site 637382003827 transcriptional regulator RcsB; Provisional; Region: PRK10840 637382003828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382003829 active site 637382003830 phosphorylation site [posttranslational modification] 637382003831 intermolecular recognition site; other site 637382003832 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382003833 DNA binding residues [nucleotide binding] 637382003834 dimerization interface [polypeptide binding]; other site 637382003835 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637382003836 putative binding surface; other site 637382003837 active site 637382003838 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 637382003839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382003840 ATP binding site [chemical binding]; other site 637382003841 Mg2+ binding site [ion binding]; other site 637382003842 G-X-G motif; other site 637382003843 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 637382003844 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 637382003845 trimer interface [polypeptide binding]; other site 637382003846 eyelet of channel; other site 637382003847 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382003848 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 637382003849 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 637382003850 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 637382003851 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 637382003852 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 637382003853 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 637382003854 Cache domain; Region: Cache_1; pfam02743 637382003855 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382003856 dimerization interface [polypeptide binding]; other site 637382003857 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 637382003858 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637382003859 dimer interface [polypeptide binding]; other site 637382003860 putative CheW interface [polypeptide binding]; other site 637382003861 Outer membrane protease [Cell envelope biogenesis, outer membrane]; Region: OmpT; COG4571 637382003862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637382003863 non-specific DNA binding site [nucleotide binding]; other site 637382003864 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 637382003865 salt bridge; other site 637382003866 sequence-specific DNA binding site [nucleotide binding]; other site 637382003867 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 637382003868 Catalytic site [active] 637382003869 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 637382003870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 637382003871 putative aldolase; Validated; Region: PRK08130 637382003872 intersubunit interface [polypeptide binding]; other site 637382003873 active site 637382003874 Zn2+ binding site [ion binding]; other site 637382003875 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637382003876 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 637382003877 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637382003878 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 637382003879 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637382003880 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 637382003881 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 637382003882 Phage tail tube protein; Region: Tail_tube; pfam10618 637382003883 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 637382003884 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 637382003885 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 637382003886 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637382003887 Mu-like prophage protein gp45 [Function unknown]; Region: COG4384 637382003888 Mu-like prophage protein gp46 [Function unknown]; Region: COG4381 637382003889 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 637382003890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 637382003891 Phage Tail Collar Domain; Region: Collar; pfam07484 637382003892 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637382003893 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637382003894 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637382003895 putative active site [active] 637382003896 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 637382003897 beta-galactosidase; Region: BGL; TIGR03356 637382003898 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 637382003899 active site 637382003900 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 637382003901 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 637382003902 Sulfatase; Region: Sulfatase; cl17466 637382003903 Nucleoid-associated protein [General function prediction only]; Region: COG3081 637382003904 nucleoid-associated protein NdpA; Validated; Region: PRK00378 637382003905 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382003906 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 637382003907 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637382003908 ATP binding site [chemical binding]; other site 637382003909 putative Mg++ binding site [ion binding]; other site 637382003910 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382003911 nucleotide binding region [chemical binding]; other site 637382003912 ATP-binding site [chemical binding]; other site 637382003913 Double zinc ribbon; Region: DZR; pfam12773 637382003914 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 637382003915 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637382003916 RNA binding surface [nucleotide binding]; other site 637382003917 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 637382003918 active site 637382003919 uracil binding [chemical binding]; other site 637382003920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382003921 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 637382003922 putative substrate translocation pore; other site 637382003923 hypothetical protein; Provisional; Region: PRK11835 637382003924 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 637382003925 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382003926 Walker A/P-loop; other site 637382003927 ATP binding site [chemical binding]; other site 637382003928 Q-loop/lid; other site 637382003929 ABC transporter signature motif; other site 637382003930 Walker B; other site 637382003931 D-loop; other site 637382003932 H-loop/switch region; other site 637382003933 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637382003934 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382003935 Walker A/P-loop; other site 637382003936 ATP binding site [chemical binding]; other site 637382003937 Q-loop/lid; other site 637382003938 ABC transporter signature motif; other site 637382003939 Walker B; other site 637382003940 D-loop; other site 637382003941 H-loop/switch region; other site 637382003942 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 637382003943 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637382003944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382003945 dimer interface [polypeptide binding]; other site 637382003946 conserved gate region; other site 637382003947 putative PBP binding loops; other site 637382003948 ABC-ATPase subunit interface; other site 637382003949 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 637382003950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382003951 dimer interface [polypeptide binding]; other site 637382003952 conserved gate region; other site 637382003953 putative PBP binding loops; other site 637382003954 ABC-ATPase subunit interface; other site 637382003955 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637382003956 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 637382003957 phage resistance protein; Provisional; Region: PRK10551 637382003958 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 637382003959 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637382003960 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 637382003961 NlpC/P60 family; Region: NLPC_P60; pfam00877 637382003962 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 637382003963 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 637382003964 active site 637382003965 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 637382003966 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 637382003967 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 637382003968 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 637382003969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637382003970 DNA-binding site [nucleotide binding]; DNA binding site 637382003971 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 637382003972 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 637382003973 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 637382003974 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 637382003975 mannonate dehydratase; Provisional; Region: PRK03906 637382003976 mannonate dehydratase; Region: uxuA; TIGR00695 637382003977 elongation factor P; Provisional; Region: PRK04542 637382003978 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 637382003979 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 637382003980 RNA binding site [nucleotide binding]; other site 637382003981 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 637382003982 RNA binding site [nucleotide binding]; other site 637382003983 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 637382003984 aromatic amino acid transport protein; Region: araaP; TIGR00837 637382003985 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 637382003986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637382003987 NAD(P) binding site [chemical binding]; other site 637382003988 active site 637382003989 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 637382003990 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 637382003991 ligand binding site [chemical binding]; other site 637382003992 NAD binding site [chemical binding]; other site 637382003993 catalytic site [active] 637382003994 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 637382003995 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 637382003996 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 637382003997 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 637382003998 tetramerization interface [polypeptide binding]; other site 637382003999 NAD(P) binding site [chemical binding]; other site 637382004000 catalytic residues [active] 637382004001 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 637382004002 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 637382004003 N- and C-terminal domain interface [polypeptide binding]; other site 637382004004 active site 637382004005 MgATP binding site [chemical binding]; other site 637382004006 catalytic site [active] 637382004007 metal binding site [ion binding]; metal-binding site 637382004008 xylulose binding site [chemical binding]; other site 637382004009 homodimer interface [polypeptide binding]; other site 637382004010 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 637382004011 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637382004012 active site 637382004013 dimer interface [polypeptide binding]; other site 637382004014 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 637382004015 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 637382004016 ligand binding site [chemical binding]; other site 637382004017 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637382004018 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382004019 Walker A/P-loop; other site 637382004020 ATP binding site [chemical binding]; other site 637382004021 Q-loop/lid; other site 637382004022 ABC transporter signature motif; other site 637382004023 Walker B; other site 637382004024 D-loop; other site 637382004025 H-loop/switch region; other site 637382004026 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382004027 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382004028 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382004029 TM-ABC transporter signature motif; other site 637382004030 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 637382004031 nudix motif; other site 637382004032 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 637382004033 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637382004034 active site 637382004035 phosphorylation site [posttranslational modification] 637382004036 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 637382004037 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637382004038 dimerization domain swap beta strand [polypeptide binding]; other site 637382004039 regulatory protein interface [polypeptide binding]; other site 637382004040 active site 637382004041 regulatory phosphorylation site [posttranslational modification]; other site 637382004042 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 637382004043 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 637382004044 putative substrate binding site [chemical binding]; other site 637382004045 putative ATP binding site [chemical binding]; other site 637382004046 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 637382004047 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 637382004048 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 637382004049 active site 637382004050 P-loop; other site 637382004051 phosphorylation site [posttranslational modification] 637382004052 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 637382004053 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 637382004054 DNA binding site [nucleotide binding] 637382004055 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 637382004056 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382004057 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637382004058 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637382004059 PapC N-terminal domain; Region: PapC_N; pfam13954 637382004060 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382004061 PapC C-terminal domain; Region: PapC_C; pfam13953 637382004062 endonuclease IV; Provisional; Region: PRK01060 637382004063 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 637382004064 AP (apurinic/apyrimidinic) site pocket; other site 637382004065 DNA interaction; other site 637382004066 Metal-binding active site; metal-binding site 637382004067 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 637382004068 Predicted membrane protein [Function unknown]; Region: COG2855 637382004069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382004070 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 637382004071 putative dimerization interface [polypeptide binding]; other site 637382004072 lysine transporter; Provisional; Region: PRK10836 637382004073 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 637382004074 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 637382004075 putative ligand binding residues [chemical binding]; other site 637382004076 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637382004077 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 637382004078 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382004079 ABC-ATPase subunit interface; other site 637382004080 dimer interface [polypeptide binding]; other site 637382004081 putative PBP binding regions; other site 637382004082 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637382004083 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637382004084 Walker A/P-loop; other site 637382004085 ATP binding site [chemical binding]; other site 637382004086 Q-loop/lid; other site 637382004087 ABC transporter signature motif; other site 637382004088 Walker B; other site 637382004089 D-loop; other site 637382004090 H-loop/switch region; other site 637382004091 putative outer membrane receptor; Provisional; Region: PRK13513 637382004092 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637382004093 N-terminal plug; other site 637382004094 ligand-binding site [chemical binding]; other site 637382004095 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 637382004096 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 637382004097 putative C-terminal domain interface [polypeptide binding]; other site 637382004098 putative GSH binding site (G-site) [chemical binding]; other site 637382004099 putative dimer interface [polypeptide binding]; other site 637382004100 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 637382004101 putative N-terminal domain interface [polypeptide binding]; other site 637382004102 putative dimer interface [polypeptide binding]; other site 637382004103 putative substrate binding pocket (H-site) [chemical binding]; other site 637382004104 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 637382004105 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637382004106 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 637382004107 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 637382004108 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 637382004109 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 637382004110 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 637382004111 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 637382004112 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 637382004113 Walker A/P-loop; other site 637382004114 ATP binding site [chemical binding]; other site 637382004115 Q-loop/lid; other site 637382004116 ABC transporter signature motif; other site 637382004117 Walker B; other site 637382004118 D-loop; other site 637382004119 H-loop/switch region; other site 637382004120 NIL domain; Region: NIL; pfam09383 637382004121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382004122 dimer interface [polypeptide binding]; other site 637382004123 conserved gate region; other site 637382004124 ABC-ATPase subunit interface; other site 637382004125 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 637382004126 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 637382004127 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 637382004128 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 637382004129 serine transporter; Region: stp; TIGR00814 637382004130 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 637382004131 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 637382004132 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637382004133 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 637382004134 intersubunit interface [polypeptide binding]; other site 637382004135 active site 637382004136 catalytic residue [active] 637382004137 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 637382004138 active site 637382004139 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 637382004140 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 637382004141 active site 637382004142 putative transporter; Provisional; Region: PRK04972 637382004143 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 637382004144 TrkA-C domain; Region: TrkA_C; pfam02080 637382004145 TrkA-C domain; Region: TrkA_C; pfam02080 637382004146 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 637382004147 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 637382004148 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 637382004149 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 637382004150 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 637382004151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382004152 Walker A/P-loop; other site 637382004153 ATP binding site [chemical binding]; other site 637382004154 Q-loop/lid; other site 637382004155 ABC transporter signature motif; other site 637382004156 Walker B; other site 637382004157 D-loop; other site 637382004158 H-loop/switch region; other site 637382004159 TOBE domain; Region: TOBE_2; pfam08402 637382004160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382004161 dimer interface [polypeptide binding]; other site 637382004162 conserved gate region; other site 637382004163 putative PBP binding loops; other site 637382004164 ABC-ATPase subunit interface; other site 637382004165 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 637382004166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382004167 dimer interface [polypeptide binding]; other site 637382004168 conserved gate region; other site 637382004169 putative PBP binding loops; other site 637382004170 ABC-ATPase subunit interface; other site 637382004171 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 637382004172 potential frameshift: common BLAST hit: gi|294503331|ref|YP_003567393.1| 23S rRNA (uracil-5-)-methyltransferase 637382004173 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 637382004174 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 637382004175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382004176 S-adenosylmethionine binding site [chemical binding]; other site 637382004177 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 637382004178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382004179 substrate binding pocket [chemical binding]; other site 637382004180 membrane-bound complex binding site; other site 637382004181 hinge residues; other site 637382004182 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 637382004183 SPFH domain / Band 7 family; Region: Band_7; pfam01145 637382004184 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637382004185 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 637382004186 putative ligand binding residues [chemical binding]; other site 637382004187 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 637382004188 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637382004189 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382004190 putative PBP binding regions; other site 637382004191 ABC-ATPase subunit interface; other site 637382004192 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637382004193 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637382004194 Walker A/P-loop; other site 637382004195 ATP binding site [chemical binding]; other site 637382004196 Q-loop/lid; other site 637382004197 ABC transporter signature motif; other site 637382004198 Walker B; other site 637382004199 D-loop; other site 637382004200 H-loop/switch region; other site 637382004201 Nicotianamine synthase protein; Region: NAS; cl17658 637382004202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 637382004203 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 637382004204 EamA-like transporter family; Region: EamA; pfam00892 637382004205 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 637382004206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382004207 dimer interface [polypeptide binding]; other site 637382004208 conserved gate region; other site 637382004209 putative PBP binding loops; other site 637382004210 ABC-ATPase subunit interface; other site 637382004211 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637382004212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382004213 dimer interface [polypeptide binding]; other site 637382004214 conserved gate region; other site 637382004215 putative PBP binding loops; other site 637382004216 ABC-ATPase subunit interface; other site 637382004217 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 637382004218 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382004219 substrate binding pocket [chemical binding]; other site 637382004220 membrane-bound complex binding site; other site 637382004221 hinge residues; other site 637382004222 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 637382004223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382004224 Walker A/P-loop; other site 637382004225 ATP binding site [chemical binding]; other site 637382004226 Q-loop/lid; other site 637382004227 ABC transporter signature motif; other site 637382004228 Walker B; other site 637382004229 D-loop; other site 637382004230 H-loop/switch region; other site 637382004231 chorismate mutase; Provisional; Region: PRK08055 637382004232 putative lipoprotein; Provisional; Region: PRK10533 637382004233 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637382004234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637382004235 NAD(P) binding site [chemical binding]; other site 637382004236 active site 637382004237 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 637382004238 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 637382004239 putative NAD(P) binding site [chemical binding]; other site 637382004240 putative active site [active] 637382004241 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 637382004242 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 637382004243 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 637382004244 tetramer interface [polypeptide binding]; other site 637382004245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382004246 catalytic residue [active] 637382004247 pyruvate dehydrogenase; Provisional; Region: PRK09124 637382004248 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 637382004249 PYR/PP interface [polypeptide binding]; other site 637382004250 dimer interface [polypeptide binding]; other site 637382004251 tetramer interface [polypeptide binding]; other site 637382004252 TPP binding site [chemical binding]; other site 637382004253 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637382004254 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 637382004255 TPP-binding site [chemical binding]; other site 637382004256 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 637382004257 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 637382004258 FAD binding pocket [chemical binding]; other site 637382004259 FAD binding motif [chemical binding]; other site 637382004260 phosphate binding motif [ion binding]; other site 637382004261 beta-alpha-beta structure motif; other site 637382004262 NAD binding pocket [chemical binding]; other site 637382004263 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637382004264 catalytic loop [active] 637382004265 iron binding site [ion binding]; other site 637382004266 hybrid cluster protein; Provisional; Region: PRK05290 637382004267 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637382004268 ACS interaction site; other site 637382004269 CODH interaction site; other site 637382004270 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 637382004271 hybrid metal cluster; other site 637382004272 Predicted membrane protein [Function unknown]; Region: COG2431 637382004273 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 637382004274 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 637382004275 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 637382004276 putative active site [active] 637382004277 putative metal-binding site [ion binding]; other site 637382004278 Protein of unknown function (DUF535); Region: DUF535; pfam04393 637382004279 macrolide transporter subunit MacA; Provisional; Region: PRK11578 637382004280 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382004281 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382004282 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 637382004283 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637382004284 Walker A/P-loop; other site 637382004285 ATP binding site [chemical binding]; other site 637382004286 Q-loop/lid; other site 637382004287 ABC transporter signature motif; other site 637382004288 Walker B; other site 637382004289 D-loop; other site 637382004290 H-loop/switch region; other site 637382004291 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637382004292 FtsX-like permease family; Region: FtsX; pfam02687 637382004293 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 637382004294 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 637382004295 Clp amino terminal domain; Region: Clp_N; pfam02861 637382004296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382004297 Walker A motif; other site 637382004298 ATP binding site [chemical binding]; other site 637382004299 Walker B motif; other site 637382004300 arginine finger; other site 637382004301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382004302 Walker A motif; other site 637382004303 ATP binding site [chemical binding]; other site 637382004304 Walker B motif; other site 637382004305 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637382004306 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382004307 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 637382004308 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 637382004309 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 637382004310 Walker A/P-loop; other site 637382004311 ATP binding site [chemical binding]; other site 637382004312 Q-loop/lid; other site 637382004313 ABC transporter signature motif; other site 637382004314 Walker B; other site 637382004315 D-loop; other site 637382004316 H-loop/switch region; other site 637382004317 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 637382004318 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637382004319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382004320 Walker A/P-loop; other site 637382004321 ATP binding site [chemical binding]; other site 637382004322 Q-loop/lid; other site 637382004323 ABC transporter signature motif; other site 637382004324 Walker B; other site 637382004325 D-loop; other site 637382004326 H-loop/switch region; other site 637382004327 thioredoxin reductase; Provisional; Region: PRK10262 637382004328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637382004329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637382004330 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 637382004331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637382004332 putative DNA binding site [nucleotide binding]; other site 637382004333 putative Zn2+ binding site [ion binding]; other site 637382004334 AsnC family; Region: AsnC_trans_reg; pfam01037 637382004335 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 637382004336 DNA translocase FtsK; Provisional; Region: PRK10263 637382004337 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637382004338 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 637382004339 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 637382004340 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 637382004341 recombination factor protein RarA; Reviewed; Region: PRK13342 637382004342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382004343 Walker A motif; other site 637382004344 ATP binding site [chemical binding]; other site 637382004345 Walker B motif; other site 637382004346 arginine finger; other site 637382004347 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 637382004348 seryl-tRNA synthetase; Provisional; Region: PRK05431 637382004349 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 637382004350 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 637382004351 dimer interface [polypeptide binding]; other site 637382004352 active site 637382004353 motif 1; other site 637382004354 motif 2; other site 637382004355 motif 3; other site 637382004356 putative MFS family transporter protein; Provisional; Region: PRK03633 637382004357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382004358 putative substrate translocation pore; other site 637382004359 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 637382004360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382004361 FeS/SAM binding site; other site 637382004362 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 637382004363 potential frameshift: common BLAST hit: gi|294503373|ref|YP_003567435.1| formate acetyltransferase 1 637382004364 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 637382004365 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 637382004366 formate transporter; Provisional; Region: PRK10805 637382004367 uncharacterized domain; Region: TIGR00702 637382004368 YcaO-like family; Region: YcaO; pfam02624 637382004369 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 637382004370 active site 637382004371 homodimer interface [polypeptide binding]; other site 637382004372 homotetramer interface [polypeptide binding]; other site 637382004373 Haemagglutinin; Region: HIM; pfam05662 637382004374 YadA-like C-terminal region; Region: YadA; pfam03895 637382004375 YadA-like C-terminal region; Region: YadA; pfam03895 637382004376 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 637382004377 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382004378 catalytic residue [active] 637382004379 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 637382004380 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 637382004381 hinge; other site 637382004382 active site 637382004383 cytidylate kinase; Provisional; Region: cmk; PRK00023 637382004384 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 637382004385 CMP-binding site; other site 637382004386 The sites determining sugar specificity; other site 637382004387 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 637382004388 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 637382004389 RNA binding site [nucleotide binding]; other site 637382004390 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 637382004391 RNA binding site [nucleotide binding]; other site 637382004392 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 637382004393 RNA binding site [nucleotide binding]; other site 637382004394 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 637382004395 RNA binding site [nucleotide binding]; other site 637382004396 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 637382004397 RNA binding site [nucleotide binding]; other site 637382004398 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 637382004399 RNA binding site [nucleotide binding]; other site 637382004400 ComEC family competence protein; Provisional; Region: PRK11539 637382004401 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 637382004402 Competence protein; Region: Competence; pfam03772 637382004403 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 637382004404 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 637382004405 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637382004406 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 637382004407 Walker A/P-loop; other site 637382004408 ATP binding site [chemical binding]; other site 637382004409 Q-loop/lid; other site 637382004410 ABC transporter signature motif; other site 637382004411 Walker B; other site 637382004412 D-loop; other site 637382004413 H-loop/switch region; other site 637382004414 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 637382004415 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 637382004416 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 637382004417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 637382004418 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 637382004419 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 637382004420 Ligand binding site; other site 637382004421 oligomer interface; other site 637382004422 hypothetical protein; Provisional; Region: PRK10593 637382004423 Methyltransferase domain; Region: Methyltransf_31; pfam13847 637382004424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382004425 S-adenosylmethionine binding site [chemical binding]; other site 637382004426 condesin subunit F; Provisional; Region: PRK05260 637382004427 condesin subunit E; Provisional; Region: PRK05256 637382004428 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 637382004429 P-loop containing region of AAA domain; Region: AAA_29; cl17516 637382004430 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 637382004431 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382004432 murein L,D-transpeptidase; Provisional; Region: PRK10594 637382004433 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637382004434 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637382004435 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637382004436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 637382004437 Peptidase M15; Region: Peptidase_M15_3; cl01194 637382004438 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 637382004439 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 637382004440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637382004441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382004442 homodimer interface [polypeptide binding]; other site 637382004443 catalytic residue [active] 637382004444 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 637382004445 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 637382004446 trimer interface [polypeptide binding]; other site 637382004447 eyelet of channel; other site 637382004448 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 637382004449 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 637382004450 putative dimer interface [polypeptide binding]; other site 637382004451 putative anticodon binding site; other site 637382004452 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 637382004453 homodimer interface [polypeptide binding]; other site 637382004454 motif 1; other site 637382004455 motif 2; other site 637382004456 active site 637382004457 motif 3; other site 637382004458 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 637382004459 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 637382004460 active site 637382004461 potential frameshift: common BLAST hit: gi|294503401|ref|YP_003567463.1| putative aminopeptidase N 637382004462 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 637382004463 Peptidase family M1; Region: Peptidase_M1; pfam01433 637382004464 Zn binding site [ion binding]; other site 637382004465 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 637382004466 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 637382004467 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 637382004468 quinone interaction residues [chemical binding]; other site 637382004469 active site 637382004470 catalytic residues [active] 637382004471 FMN binding site [chemical binding]; other site 637382004472 substrate binding site [chemical binding]; other site 637382004473 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 637382004474 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 637382004475 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 637382004476 MOSC domain; Region: MOSC; pfam03473 637382004477 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637382004478 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 637382004479 catalytic loop [active] 637382004480 iron binding site [ion binding]; other site 637382004481 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 637382004482 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 637382004483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382004484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382004485 S-adenosylmethionine binding site [chemical binding]; other site 637382004486 ABC transporter ATPase component; Reviewed; Region: PRK11147 637382004487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382004488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382004489 Walker A/P-loop; other site 637382004490 Walker A/P-loop; other site 637382004491 ATP binding site [chemical binding]; other site 637382004492 ATP binding site [chemical binding]; other site 637382004493 Q-loop/lid; other site 637382004494 Q-loop/lid; other site 637382004495 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637382004496 ABC transporter signature motif; other site 637382004497 Walker B; other site 637382004498 D-loop; other site 637382004499 ABC transporter; Region: ABC_tran_2; pfam12848 637382004500 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637382004501 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 637382004502 Paraquat-inducible protein A; Region: PqiA; pfam04403 637382004503 Paraquat-inducible protein A; Region: PqiA; pfam04403 637382004504 paraquat-inducible protein B; Provisional; Region: PRK10807 637382004505 mce related protein; Region: MCE; pfam02470 637382004506 mce related protein; Region: MCE; pfam02470 637382004507 mce related protein; Region: MCE; pfam02470 637382004508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 637382004509 Protein of unknown function (DUF330); Region: DUF330; pfam03886 637382004510 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382004511 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 637382004512 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637382004513 dimer interface [polypeptide binding]; other site 637382004514 active site 637382004515 transposase/IS protein; Provisional; Region: PRK09183 637382004516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382004517 Walker A motif; other site 637382004518 ATP binding site [chemical binding]; other site 637382004519 Walker B motif; other site 637382004520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382004521 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382004522 DNA-binding interface [nucleotide binding]; DNA binding site 637382004523 Integrase core domain; Region: rve; pfam00665 637382004524 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 637382004525 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 637382004526 active site 2 [active] 637382004527 dimer interface [polypeptide binding]; other site 637382004528 active site 1 [active] 637382004529 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 637382004530 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 637382004531 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 637382004532 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382004533 outer membrane protein A; Reviewed; Region: PRK10808 637382004534 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 637382004535 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637382004536 ligand binding site [chemical binding]; other site 637382004537 SOS-response cell division inhibitor, blocks FtsZ ring formation [Cell division and chromosome partitioning]; Region: SulA; COG5404 637382004538 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 637382004539 TfoX C-terminal domain; Region: TfoX_C; pfam04994 637382004540 TIGR01666 family membrane protein; Region: YCCS 637382004541 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 637382004542 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 637382004543 Predicted membrane protein [Function unknown]; Region: COG3304 637382004544 Domain of unknown function (DUF307); Region: DUF307; pfam03733 637382004545 DNA helicase IV; Provisional; Region: helD; PRK11054 637382004546 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 637382004547 Part of AAA domain; Region: AAA_19; pfam13245 637382004548 Family description; Region: UvrD_C_2; pfam13538 637382004549 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 637382004550 active site 637382004551 dimer interfaces [polypeptide binding]; other site 637382004552 catalytic residues [active] 637382004553 hypothetical protein; Provisional; Region: PRK03641 637382004554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 637382004555 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 637382004556 heat shock protein HspQ; Provisional; Region: PRK14129 637382004557 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 637382004558 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 637382004559 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 637382004560 putative RNA binding site [nucleotide binding]; other site 637382004561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382004562 S-adenosylmethionine binding site [chemical binding]; other site 637382004563 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 637382004564 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 637382004565 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 637382004566 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 637382004567 FAD binding domain; Region: FAD_binding_4; pfam01565 637382004568 short chain dehydrogenase; Provisional; Region: PRK06172 637382004569 classical (c) SDRs; Region: SDR_c; cd05233 637382004570 NAD(P) binding site [chemical binding]; other site 637382004571 active site 637382004572 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 637382004573 active site 2 [active] 637382004574 dimer interface [polypeptide binding]; other site 637382004575 active site 1 [active] 637382004576 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 637382004577 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637382004578 dimer interface [polypeptide binding]; other site 637382004579 active site 637382004580 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 637382004581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637382004582 NAD(P) binding site [chemical binding]; other site 637382004583 active site 637382004584 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 637382004585 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 637382004586 dimer interface [polypeptide binding]; other site 637382004587 active site 637382004588 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 637382004589 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 637382004590 substrate binding site [chemical binding]; other site 637382004591 oxyanion hole (OAH) forming residues; other site 637382004592 trimer interface [polypeptide binding]; other site 637382004593 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 637382004594 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 637382004595 substrate binding site [chemical binding]; other site 637382004596 oxyanion hole (OAH) forming residues; other site 637382004597 trimer interface [polypeptide binding]; other site 637382004598 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 637382004599 classical (c) SDRs; Region: SDR_c; cd05233 637382004600 NAD(P) binding site [chemical binding]; other site 637382004601 active site 637382004602 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 637382004603 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 637382004604 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 637382004605 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 637382004606 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 637382004607 Protein of unknown function (DUF877); Region: DUF877; pfam05943 637382004608 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 637382004609 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 637382004610 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 637382004611 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 637382004612 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637382004613 ligand binding site [chemical binding]; other site 637382004614 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 637382004615 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 637382004616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382004617 Walker A motif; other site 637382004618 ATP binding site [chemical binding]; other site 637382004619 Walker B motif; other site 637382004620 arginine finger; other site 637382004621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382004622 Walker A motif; other site 637382004623 ATP binding site [chemical binding]; other site 637382004624 Walker B motif; other site 637382004625 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637382004626 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 637382004627 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637382004628 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 637382004629 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 637382004630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 637382004631 Peptidase family M23; Region: Peptidase_M23; pfam01551 637382004632 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 637382004633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 637382004634 Peptidase family M23; Region: Peptidase_M23; pfam01551 637382004635 Peptidase family M23; Region: Peptidase_M23; pfam01551 637382004636 Winged helix-turn helix; Region: HTH_33; pfam13592 637382004637 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 637382004638 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 637382004639 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 637382004640 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 637382004641 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 637382004642 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 637382004643 PAAR motif; Region: PAAR_motif; pfam05488 637382004644 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 637382004645 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 637382004646 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 637382004647 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 637382004648 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 637382004649 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 637382004650 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 637382004651 ImpA domain protein; Region: DUF3702; pfam12486 637382004652 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 637382004653 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 637382004654 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637382004655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382004656 Walker A/P-loop; other site 637382004657 ATP binding site [chemical binding]; other site 637382004658 ABC transporter signature motif; other site 637382004659 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637382004660 Walker B; other site 637382004661 ABC transporter; Region: ABC_tran_2; pfam12848 637382004662 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637382004663 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382004664 MULE transposase domain; Region: MULE; pfam10551 637382004665 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 637382004666 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 637382004667 ATP binding site [chemical binding]; other site 637382004668 substrate interface [chemical binding]; other site 637382004669 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 637382004670 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 637382004671 dimer interface [polypeptide binding]; other site 637382004672 putative functional site; other site 637382004673 putative MPT binding site; other site 637382004674 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382004675 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 637382004676 FeS/SAM binding site; other site 637382004677 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 637382004678 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637382004679 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637382004680 Walker A/P-loop; other site 637382004681 ATP binding site [chemical binding]; other site 637382004682 Q-loop/lid; other site 637382004683 ABC transporter signature motif; other site 637382004684 Walker B; other site 637382004685 D-loop; other site 637382004686 H-loop/switch region; other site 637382004687 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 637382004688 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382004689 S-formylglutathione hydrolase; Region: PLN02442 637382004690 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 637382004691 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 637382004692 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 637382004693 substrate binding site [chemical binding]; other site 637382004694 catalytic Zn binding site [ion binding]; other site 637382004695 NAD binding site [chemical binding]; other site 637382004696 structural Zn binding site [ion binding]; other site 637382004697 dimer interface [polypeptide binding]; other site 637382004698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382004699 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382004700 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 637382004701 putative dimerization interface [polypeptide binding]; other site 637382004702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382004703 putative substrate translocation pore; other site 637382004704 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 637382004705 GTP cyclohydrolase I; Provisional; Region: PLN03044 637382004706 active site 637382004707 Predicted membrane protein [Function unknown]; Region: COG2311 637382004708 hypothetical protein; Provisional; Region: PRK10835 637382004709 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 637382004710 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 637382004711 ligand binding site [chemical binding]; other site 637382004712 calcium binding site [ion binding]; other site 637382004713 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382004714 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 637382004715 Walker A/P-loop; other site 637382004716 ATP binding site [chemical binding]; other site 637382004717 Q-loop/lid; other site 637382004718 ABC transporter signature motif; other site 637382004719 Walker B; other site 637382004720 D-loop; other site 637382004721 H-loop/switch region; other site 637382004722 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382004723 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382004724 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382004725 TM-ABC transporter signature motif; other site 637382004726 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637382004727 putative active site [active] 637382004728 malate dehydrogenase; Provisional; Region: PRK13529 637382004729 Malic enzyme, N-terminal domain; Region: malic; pfam00390 637382004730 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 637382004731 NAD(P) binding site [chemical binding]; other site 637382004732 cytidine deaminase; Provisional; Region: PRK09027 637382004733 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 637382004734 active site 637382004735 catalytic motif [active] 637382004736 Zn binding site [ion binding]; other site 637382004737 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 637382004738 active site 637382004739 catalytic motif [active] 637382004740 Zn binding site [ion binding]; other site 637382004741 hypothetical protein; Provisional; Region: PRK10711 637382004742 hypothetical protein; Provisional; Region: PRK01821 637382004743 putative transporter; Provisional; Region: PRK10054 637382004744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382004745 putative substrate translocation pore; other site 637382004746 Uncharacterized conserved protein [Function unknown]; Region: COG5276 637382004747 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 637382004748 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 637382004749 putative ligand binding site [chemical binding]; other site 637382004750 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382004751 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 637382004752 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637382004753 active site 637382004754 KMSKS motif; other site 637382004755 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 637382004756 tRNA binding surface [nucleotide binding]; other site 637382004757 anticodon binding site; other site 637382004758 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 637382004759 dimer interface [polypeptide binding]; other site 637382004760 putative tRNA-binding site [nucleotide binding]; other site 637382004761 antiporter inner membrane protein; Provisional; Region: PRK11670 637382004762 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 637382004763 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 637382004764 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 637382004765 ATP-binding site [chemical binding]; other site 637382004766 Sugar specificity; other site 637382004767 Pyrimidine base specificity; other site 637382004768 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 637382004769 trimer interface [polypeptide binding]; other site 637382004770 active site 637382004771 putative assembly protein; Provisional; Region: PRK10833 637382004772 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 637382004773 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 637382004774 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 637382004775 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637382004776 Transporter associated domain; Region: CorC_HlyC; smart01091 637382004777 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 637382004778 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 637382004779 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 637382004780 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 637382004781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382004782 catalytic residue [active] 637382004783 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 637382004784 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637382004785 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 637382004786 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 637382004787 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 637382004788 IucA / IucC family; Region: IucA_IucC; pfam04183 637382004789 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 637382004790 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637382004791 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637382004792 Walker A/P-loop; other site 637382004793 ATP binding site [chemical binding]; other site 637382004794 Q-loop/lid; other site 637382004795 ABC transporter signature motif; other site 637382004796 Walker B; other site 637382004797 D-loop; other site 637382004798 H-loop/switch region; other site 637382004799 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 637382004800 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 637382004801 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382004802 ABC-ATPase subunit interface; other site 637382004803 dimer interface [polypeptide binding]; other site 637382004804 putative PBP binding regions; other site 637382004805 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637382004806 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382004807 ABC-ATPase subunit interface; other site 637382004808 dimer interface [polypeptide binding]; other site 637382004809 putative PBP binding regions; other site 637382004810 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637382004811 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 637382004812 siderophore binding site; other site 637382004813 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 637382004814 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637382004815 N-terminal plug; other site 637382004816 ligand-binding site [chemical binding]; other site 637382004817 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 637382004818 IucA / IucC family; Region: IucA_IucC; pfam04183 637382004819 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 637382004820 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 637382004821 active site 637382004822 tetramer interface; other site 637382004823 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 637382004824 active site 637382004825 tetramer interface; other site 637382004826 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 637382004827 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 637382004828 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 637382004829 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 637382004830 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 637382004831 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 637382004832 metal binding site [ion binding]; metal-binding site 637382004833 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 637382004834 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 637382004835 substrate binding site [chemical binding]; other site 637382004836 glutamase interaction surface [polypeptide binding]; other site 637382004837 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 637382004838 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 637382004839 catalytic residues [active] 637382004840 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 637382004841 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 637382004842 putative active site [active] 637382004843 oxyanion strand; other site 637382004844 catalytic triad [active] 637382004845 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 637382004846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382004847 active site 637382004848 motif I; other site 637382004849 motif II; other site 637382004850 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 637382004851 putative active site pocket [active] 637382004852 4-fold oligomerization interface [polypeptide binding]; other site 637382004853 metal binding residues [ion binding]; metal-binding site 637382004854 3-fold/trimer interface [polypeptide binding]; other site 637382004855 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 637382004856 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637382004857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382004858 homodimer interface [polypeptide binding]; other site 637382004859 catalytic residue [active] 637382004860 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 637382004861 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 637382004862 NAD binding site [chemical binding]; other site 637382004863 dimerization interface [polypeptide binding]; other site 637382004864 product binding site; other site 637382004865 substrate binding site [chemical binding]; other site 637382004866 zinc binding site [ion binding]; other site 637382004867 catalytic residues [active] 637382004868 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 637382004869 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 637382004870 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 637382004871 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637382004872 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 637382004873 putative NAD(P) binding site [chemical binding]; other site 637382004874 Yersinia protein of unknown function (DUF3831); Region: DUF3831; pfam12908 637382004875 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382004876 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382004877 TM-ABC transporter signature motif; other site 637382004878 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637382004879 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382004880 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 637382004881 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382004882 Walker A/P-loop; other site 637382004883 ATP binding site [chemical binding]; other site 637382004884 Q-loop/lid; other site 637382004885 ABC transporter signature motif; other site 637382004886 Walker B; other site 637382004887 D-loop; other site 637382004888 H-loop/switch region; other site 637382004889 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 637382004890 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 637382004891 putative active site [active] 637382004892 metal binding site [ion binding]; metal-binding site 637382004893 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 637382004894 exonuclease I; Provisional; Region: sbcB; PRK11779 637382004895 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 637382004896 active site 637382004897 catalytic site [active] 637382004898 substrate binding site [chemical binding]; other site 637382004899 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 637382004900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637382004901 NAD(P) binding site [chemical binding]; other site 637382004902 active site 637382004903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382004904 MULE transposase domain; Region: MULE; pfam10551 637382004905 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 637382004906 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637382004907 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637382004908 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637382004909 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 637382004910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382004911 putative substrate translocation pore; other site 637382004912 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 637382004913 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 637382004914 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 637382004915 NAD binding site [chemical binding]; other site 637382004916 homotetramer interface [polypeptide binding]; other site 637382004917 homodimer interface [polypeptide binding]; other site 637382004918 active site 637382004919 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 637382004920 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 637382004921 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 637382004922 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 637382004923 putative active site pocket [active] 637382004924 metal binding site [ion binding]; metal-binding site 637382004925 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 637382004926 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 637382004927 phosphate binding site [ion binding]; other site 637382004928 argininosuccinate synthase; Validated; Region: PRK05370 637382004929 MATE family multidrug exporter; Provisional; Region: PRK10189 637382004930 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 637382004931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382004932 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637382004933 putative substrate translocation pore; other site 637382004934 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 637382004935 active site 637382004936 catalytic site [active] 637382004937 Zn binding site [ion binding]; other site 637382004938 tetramer interface [polypeptide binding]; other site 637382004939 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 637382004940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 637382004941 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637382004942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382004943 active site 637382004944 phosphorylation site [posttranslational modification] 637382004945 intermolecular recognition site; other site 637382004946 dimerization interface [polypeptide binding]; other site 637382004947 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382004948 DNA binding residues [nucleotide binding] 637382004949 dimerization interface [polypeptide binding]; other site 637382004950 DctM-like transporters; Region: DctM; pfam06808 637382004951 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 637382004952 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 637382004953 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 637382004954 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 637382004955 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 637382004956 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 637382004957 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 637382004958 Melibiase; Region: Melibiase; pfam02065 637382004959 galactoside permease; Reviewed; Region: lacY; PRK09528 637382004960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382004961 putative substrate translocation pore; other site 637382004962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382004963 MULE transposase domain; Region: MULE; pfam10551 637382004964 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 637382004965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382004966 motif II; other site 637382004967 YniB-like protein; Region: YniB; pfam14002 637382004968 Phosphotransferase enzyme family; Region: APH; pfam01636 637382004969 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 637382004970 active site 637382004971 ATP binding site [chemical binding]; other site 637382004972 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 637382004973 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 637382004974 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382004975 ABC-ATPase subunit interface; other site 637382004976 dimer interface [polypeptide binding]; other site 637382004977 putative PBP binding regions; other site 637382004978 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 637382004979 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382004980 ABC-ATPase subunit interface; other site 637382004981 dimer interface [polypeptide binding]; other site 637382004982 putative PBP binding regions; other site 637382004983 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 637382004984 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 637382004985 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 637382004986 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 637382004987 metal binding site [ion binding]; metal-binding site 637382004988 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 637382004989 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637382004990 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637382004991 catalytic residue [active] 637382004992 inner membrane protein; Provisional; Region: PRK10995 637382004993 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 637382004994 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 637382004995 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 637382004996 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 637382004997 active site 637382004998 dimer interface [polypeptide binding]; other site 637382004999 motif 1; other site 637382005000 motif 2; other site 637382005001 motif 3; other site 637382005002 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 637382005003 anticodon binding site; other site 637382005004 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 637382005005 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 637382005006 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 637382005007 23S rRNA binding site [nucleotide binding]; other site 637382005008 L21 binding site [polypeptide binding]; other site 637382005009 L13 binding site [polypeptide binding]; other site 637382005010 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 637382005011 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 637382005012 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 637382005013 dimer interface [polypeptide binding]; other site 637382005014 motif 1; other site 637382005015 active site 637382005016 motif 2; other site 637382005017 motif 3; other site 637382005018 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 637382005019 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 637382005020 putative tRNA-binding site [nucleotide binding]; other site 637382005021 B3/4 domain; Region: B3_4; pfam03483 637382005022 tRNA synthetase B5 domain; Region: B5; smart00874 637382005023 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 637382005024 dimer interface [polypeptide binding]; other site 637382005025 motif 1; other site 637382005026 motif 3; other site 637382005027 motif 2; other site 637382005028 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 637382005029 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 637382005030 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637382005031 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382005032 ABC-ATPase subunit interface; other site 637382005033 dimer interface [polypeptide binding]; other site 637382005034 putative PBP binding regions; other site 637382005035 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 637382005036 catalytic residues [active] 637382005037 dimer interface [polypeptide binding]; other site 637382005038 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 637382005039 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637382005040 Walker A/P-loop; other site 637382005041 ATP binding site [chemical binding]; other site 637382005042 Q-loop/lid; other site 637382005043 ABC transporter signature motif; other site 637382005044 Walker B; other site 637382005045 D-loop; other site 637382005046 H-loop/switch region; other site 637382005047 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 637382005048 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 637382005049 inhibitor-cofactor binding pocket; inhibition site 637382005050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382005051 catalytic residue [active] 637382005052 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 637382005053 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 637382005054 Putative Catalytic site; other site 637382005055 DXD motif; other site 637382005056 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 637382005057 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 637382005058 active site 637382005059 substrate binding site [chemical binding]; other site 637382005060 cosubstrate binding site; other site 637382005061 catalytic site [active] 637382005062 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 637382005063 active site 637382005064 hexamer interface [polypeptide binding]; other site 637382005065 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 637382005066 NAD binding site [chemical binding]; other site 637382005067 substrate binding site [chemical binding]; other site 637382005068 active site 637382005069 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 637382005070 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 637382005071 putative active site [active] 637382005072 putative catalytic site [active] 637382005073 putative Zn binding site [ion binding]; other site 637382005074 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 637382005075 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 637382005076 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 637382005077 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 637382005078 NlpC/P60 family; Region: NLPC_P60; pfam00877 637382005079 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 637382005080 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 637382005081 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 637382005082 hypothetical protein; Validated; Region: PRK00029 637382005083 Uncharacterized conserved protein [Function unknown]; Region: COG0397 637382005084 Uncharacterized conserved protein [Function unknown]; Region: COG0397 637382005085 hypothetical protein; Validated; Region: PRK00029 637382005086 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 637382005087 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 637382005088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 637382005089 phosphoenolpyruvate synthase; Validated; Region: PRK06464 637382005090 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 637382005091 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 637382005092 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 637382005093 putative inner membrane protein; Provisional; Region: PRK10983 637382005094 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637382005095 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 637382005096 FAD binding domain; Region: FAD_binding_4; pfam01565 637382005097 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 637382005098 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 637382005099 CoenzymeA binding site [chemical binding]; other site 637382005100 subunit interaction site [polypeptide binding]; other site 637382005101 PHB binding site; other site 637382005102 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 637382005103 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 637382005104 putative ABC transporter; Region: ycf24; CHL00085 637382005105 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 637382005106 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 637382005107 Walker A/P-loop; other site 637382005108 ATP binding site [chemical binding]; other site 637382005109 Q-loop/lid; other site 637382005110 ABC transporter signature motif; other site 637382005111 Walker B; other site 637382005112 D-loop; other site 637382005113 H-loop/switch region; other site 637382005114 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 637382005115 FeS assembly protein SufD; Region: sufD; TIGR01981 637382005116 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637382005117 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 637382005118 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382005119 catalytic residue [active] 637382005120 cysteine desufuration protein SufE; Provisional; Region: PRK09296 637382005121 L,D-transpeptidase; Provisional; Region: PRK10190 637382005122 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637382005123 transposase/IS protein; Provisional; Region: PRK09183 637382005124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382005125 Walker A motif; other site 637382005126 ATP binding site [chemical binding]; other site 637382005127 Walker B motif; other site 637382005128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382005129 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382005130 DNA-binding interface [nucleotide binding]; DNA binding site 637382005131 Integrase core domain; Region: rve; pfam00665 637382005132 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382005133 pyruvate kinase; Provisional; Region: PRK09206 637382005134 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 637382005135 domain interfaces; other site 637382005136 active site 637382005137 potential frameshift: common BLAST hit: gi|294503603|ref|YP_003567665.1| multidrug efflux protein NorA 637382005138 multidrug efflux protein; Reviewed; Region: PRK01766 637382005139 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 637382005140 cation binding site [ion binding]; other site 637382005141 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 637382005142 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 637382005143 Lumazine binding domain; Region: Lum_binding; pfam00677 637382005144 Lumazine binding domain; Region: Lum_binding; pfam00677 637382005145 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 637382005146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382005147 S-adenosylmethionine binding site [chemical binding]; other site 637382005148 putative transporter; Provisional; Region: PRK11043 637382005149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382005150 putative substrate translocation pore; other site 637382005151 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 637382005152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382005153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637382005154 dimerization interface [polypeptide binding]; other site 637382005155 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 637382005156 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382005157 DNA binding site [nucleotide binding] 637382005158 domain linker motif; other site 637382005159 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 637382005160 dimerization interface [polypeptide binding]; other site 637382005161 ligand binding site [chemical binding]; other site 637382005162 superoxide dismutase; Provisional; Region: PRK10543 637382005163 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 637382005164 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 637382005165 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 637382005166 NlpC/P60 family; Region: NLPC_P60; pfam00877 637382005167 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 637382005168 putative GSH binding site [chemical binding]; other site 637382005169 catalytic residues [active] 637382005170 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 637382005171 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 637382005172 dimer interface [polypeptide binding]; other site 637382005173 catalytic site [active] 637382005174 putative active site [active] 637382005175 putative substrate binding site [chemical binding]; other site 637382005176 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 637382005177 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 637382005178 dimer interface [polypeptide binding]; other site 637382005179 active site 637382005180 metal binding site [ion binding]; metal-binding site 637382005181 glutathione binding site [chemical binding]; other site 637382005182 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637382005183 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637382005184 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 637382005185 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 637382005186 FMN binding site [chemical binding]; other site 637382005187 active site 637382005188 substrate binding site [chemical binding]; other site 637382005189 catalytic residue [active] 637382005190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637382005191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637382005192 putative metal dependent hydrolase; Provisional; Region: PRK11598 637382005193 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 637382005194 Sulfatase; Region: Sulfatase; pfam00884 637382005195 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637382005196 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637382005197 active site 637382005198 catalytic tetrad [active] 637382005199 transcriptional regulator SlyA; Provisional; Region: PRK03573 637382005200 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 637382005201 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 637382005202 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 637382005203 Predicted periplasmic protein [General function prediction only]; Region: COG3895 637382005204 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 637382005205 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 637382005206 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 637382005207 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 637382005208 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 637382005209 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 637382005210 active site 637382005211 HIGH motif; other site 637382005212 dimer interface [polypeptide binding]; other site 637382005213 KMSKS motif; other site 637382005214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637382005215 RNA binding surface [nucleotide binding]; other site 637382005216 pyridoxamine kinase; Validated; Region: PRK05756 637382005217 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 637382005218 dimer interface [polypeptide binding]; other site 637382005219 pyridoxal binding site [chemical binding]; other site 637382005220 ATP binding site [chemical binding]; other site 637382005221 glutathionine S-transferase; Provisional; Region: PRK10542 637382005222 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 637382005223 C-terminal domain interface [polypeptide binding]; other site 637382005224 GSH binding site (G-site) [chemical binding]; other site 637382005225 dimer interface [polypeptide binding]; other site 637382005226 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 637382005227 dimer interface [polypeptide binding]; other site 637382005228 N-terminal domain interface [polypeptide binding]; other site 637382005229 substrate binding pocket (H-site) [chemical binding]; other site 637382005230 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 637382005231 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 637382005232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382005233 putative substrate translocation pore; other site 637382005234 POT family; Region: PTR2; pfam00854 637382005235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 637382005236 Uncharacterized conserved protein [Function unknown]; Region: COG2128 637382005237 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 637382005238 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 637382005239 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382005240 Walker A/P-loop; other site 637382005241 ATP binding site [chemical binding]; other site 637382005242 Q-loop/lid; other site 637382005243 ABC transporter signature motif; other site 637382005244 Walker B; other site 637382005245 D-loop; other site 637382005246 H-loop/switch region; other site 637382005247 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637382005248 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 637382005249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382005250 Walker A/P-loop; other site 637382005251 ATP binding site [chemical binding]; other site 637382005252 Q-loop/lid; other site 637382005253 ABC transporter signature motif; other site 637382005254 Walker B; other site 637382005255 D-loop; other site 637382005256 H-loop/switch region; other site 637382005257 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637382005258 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 637382005259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382005260 putative PBP binding loops; other site 637382005261 dimer interface [polypeptide binding]; other site 637382005262 ABC-ATPase subunit interface; other site 637382005263 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 637382005264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382005265 dimer interface [polypeptide binding]; other site 637382005266 conserved gate region; other site 637382005267 putative PBP binding loops; other site 637382005268 ABC-ATPase subunit interface; other site 637382005269 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 637382005270 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 637382005271 peptide binding site [polypeptide binding]; other site 637382005272 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382005273 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 637382005274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382005275 Walker A motif; other site 637382005276 ATP binding site [chemical binding]; other site 637382005277 Walker B motif; other site 637382005278 arginine finger; other site 637382005279 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 637382005280 phage shock protein PspA; Provisional; Region: PRK10698 637382005281 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 637382005282 phage shock protein C; Region: phageshock_pspC; TIGR02978 637382005283 YcjX-like family, DUF463; Region: DUF463; cl01193 637382005284 YcjX-like family, DUF463; Region: DUF463; cl01193 637382005285 hypothetical protein; Provisional; Region: PRK05415 637382005286 Domain of unknown function (DUF697); Region: DUF697; cl12064 637382005287 Uncharacterized conserved protein [Function unknown]; Region: COG5654 637382005288 Uncharacterized conserved protein [Function unknown]; Region: COG5642 637382005289 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 637382005290 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 637382005291 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 637382005292 PAS domain; Region: PAS; smart00091 637382005293 putative active site [active] 637382005294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382005295 Walker A motif; other site 637382005296 ATP binding site [chemical binding]; other site 637382005297 Walker B motif; other site 637382005298 arginine finger; other site 637382005299 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382005300 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 637382005301 dimer interface [polypeptide binding]; other site 637382005302 catalytic triad [active] 637382005303 peroxidatic and resolving cysteines [active] 637382005304 transposase/IS protein; Provisional; Region: PRK09183 637382005305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382005306 Walker A motif; other site 637382005307 ATP binding site [chemical binding]; other site 637382005308 Walker B motif; other site 637382005309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382005310 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382005311 DNA-binding interface [nucleotide binding]; DNA binding site 637382005312 Integrase core domain; Region: rve; pfam00665 637382005313 Spore Coat Protein U domain; Region: SCPU; pfam05229 637382005314 Uncharacterized secreted protein [Function unknown]; Region: COG5430 637382005315 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637382005316 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382005317 PapC C-terminal domain; Region: PapC_C; pfam13953 637382005318 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637382005319 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382005320 Uncharacterized secreted protein [Function unknown]; Region: COG5430 637382005321 Uncharacterized secreted protein [Function unknown]; Region: COG5430 637382005322 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 637382005323 mce related protein; Region: MCE; pfam02470 637382005324 mce related protein; Region: MCE; pfam02470 637382005325 mce related protein; Region: MCE; pfam02470 637382005326 mce related protein; Region: MCE; pfam02470 637382005327 mce related protein; Region: MCE; pfam02470 637382005328 mce related protein; Region: MCE; pfam02470 637382005329 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 637382005330 Paraquat-inducible protein A; Region: PqiA; pfam04403 637382005331 Paraquat-inducible protein A; Region: PqiA; pfam04403 637382005332 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 637382005333 GAF domain; Region: GAF_2; pfam13185 637382005334 ProP expression regulator; Provisional; Region: PRK04950 637382005335 ProQ/FINO family; Region: ProQ; pfam04352 637382005336 carboxy-terminal protease; Provisional; Region: PRK11186 637382005337 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 637382005338 protein binding site [polypeptide binding]; other site 637382005339 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 637382005340 Catalytic dyad [active] 637382005341 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 637382005342 heat shock protein HtpX; Provisional; Region: PRK05457 637382005343 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637382005344 putative chaperone protein EcpD; Provisional; Region: PRK09926 637382005345 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382005346 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637382005347 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637382005348 PapC N-terminal domain; Region: PapC_N; pfam13954 637382005349 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382005350 PapC C-terminal domain; Region: PapC_C; pfam13953 637382005351 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637382005352 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637382005353 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382005354 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637382005355 potential frameshift: common BLAST hit: gi|294504103|ref|YP_003568165.1| putative transport protein 637382005356 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637382005357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382005358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382005359 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 637382005360 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 637382005361 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 637382005362 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637382005363 dimerization interface [polypeptide binding]; other site 637382005364 putative Zn2+ binding site [ion binding]; other site 637382005365 putative DNA binding site [nucleotide binding]; other site 637382005366 Bacterial transcriptional regulator; Region: IclR; pfam01614 637382005367 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 637382005368 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637382005369 amidase catalytic site [active] 637382005370 Zn binding residues [ion binding]; other site 637382005371 substrate binding site [chemical binding]; other site 637382005372 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637382005373 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 637382005374 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 637382005375 inner membrane protein; Provisional; Region: PRK11648 637382005376 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 637382005377 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637382005378 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637382005379 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 637382005380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382005381 Walker A/P-loop; other site 637382005382 ATP binding site [chemical binding]; other site 637382005383 Q-loop/lid; other site 637382005384 ABC transporter signature motif; other site 637382005385 Walker B; other site 637382005386 D-loop; other site 637382005387 H-loop/switch region; other site 637382005388 TOBE domain; Region: TOBE_2; pfam08402 637382005389 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637382005390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382005391 dimer interface [polypeptide binding]; other site 637382005392 conserved gate region; other site 637382005393 putative PBP binding loops; other site 637382005394 ABC-ATPase subunit interface; other site 637382005395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382005396 dimer interface [polypeptide binding]; other site 637382005397 conserved gate region; other site 637382005398 putative PBP binding loops; other site 637382005399 ABC-ATPase subunit interface; other site 637382005400 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 637382005401 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 637382005402 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 637382005403 NADP binding site [chemical binding]; other site 637382005404 homodimer interface [polypeptide binding]; other site 637382005405 active site 637382005406 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 637382005407 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 637382005408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382005409 MULE transposase domain; Region: MULE; pfam10551 637382005410 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637382005411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382005412 DNA binding site [nucleotide binding] 637382005413 domain linker motif; other site 637382005414 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 637382005415 ligand binding site [chemical binding]; other site 637382005416 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382005417 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382005418 DNA-binding interface [nucleotide binding]; DNA binding site 637382005419 Integrase core domain; Region: rve; pfam00665 637382005420 transposase/IS protein; Provisional; Region: PRK09183 637382005421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382005422 Walker A motif; other site 637382005423 ATP binding site [chemical binding]; other site 637382005424 Walker B motif; other site 637382005425 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 637382005426 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 637382005427 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 637382005428 ATP binding site [chemical binding]; other site 637382005429 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637382005430 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637382005431 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 637382005432 Walker A/P-loop; other site 637382005433 ATP binding site [chemical binding]; other site 637382005434 Q-loop/lid; other site 637382005435 ABC transporter signature motif; other site 637382005436 Walker B; other site 637382005437 D-loop; other site 637382005438 H-loop/switch region; other site 637382005439 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 637382005440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382005441 potential frameshift: common BLAST hit: gi|294504080|ref|YP_003568142.1| aromatic amino acid transport protein 637382005442 aromatic amino acid transporter; Provisional; Region: PRK10238 637382005443 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 637382005444 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 637382005445 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 637382005446 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 637382005447 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 637382005448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382005449 S-adenosylmethionine binding site [chemical binding]; other site 637382005450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637382005451 PAS domain; Region: PAS_9; pfam13426 637382005452 putative active site [active] 637382005453 heme pocket [chemical binding]; other site 637382005454 PAS domain S-box; Region: sensory_box; TIGR00229 637382005455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637382005456 putative active site [active] 637382005457 heme pocket [chemical binding]; other site 637382005458 PAS domain S-box; Region: sensory_box; TIGR00229 637382005459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637382005460 putative active site [active] 637382005461 heme pocket [chemical binding]; other site 637382005462 PAS fold; Region: PAS; pfam00989 637382005463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637382005464 putative active site [active] 637382005465 heme pocket [chemical binding]; other site 637382005466 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637382005467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637382005468 metal binding site [ion binding]; metal-binding site 637382005469 active site 637382005470 I-site; other site 637382005471 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 637382005472 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637382005473 N-terminal plug; other site 637382005474 ligand-binding site [chemical binding]; other site 637382005475 hypothetical protein; Provisional; Region: PRK11469 637382005476 Domain of unknown function DUF; Region: DUF204; pfam02659 637382005477 Domain of unknown function DUF; Region: DUF204; pfam02659 637382005478 hypothetical protein; Provisional; Region: PRK02913 637382005479 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 637382005480 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 637382005481 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 637382005482 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 637382005483 active pocket/dimerization site; other site 637382005484 active site 637382005485 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 637382005486 active site 637382005487 phosphorylation site [posttranslational modification] 637382005488 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 637382005489 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637382005490 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637382005491 Transporter associated domain; Region: CorC_HlyC; smart01091 637382005492 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 637382005493 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637382005494 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 637382005495 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 637382005496 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 637382005497 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 637382005498 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 637382005499 NAD binding site [chemical binding]; other site 637382005500 catalytic residues [active] 637382005501 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 637382005502 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 637382005503 putative active site [active] 637382005504 putative metal binding site [ion binding]; other site 637382005505 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 637382005506 trimer interface [polypeptide binding]; other site 637382005507 putative substrate binding pocket [chemical binding]; other site 637382005508 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 637382005509 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 637382005510 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 637382005511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382005512 putative substrate translocation pore; other site 637382005513 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 637382005514 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 637382005515 4-hydroxyphenylacetate 3-monooxygenase, reductase component; Region: HpaC; TIGR02296 637382005516 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 637382005517 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 637382005518 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 637382005519 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 637382005520 putative active site [active] 637382005521 putative CoA binding site [chemical binding]; other site 637382005522 nudix motif; other site 637382005523 metal binding site [ion binding]; metal-binding site 637382005524 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 637382005525 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 637382005526 chorismate binding enzyme; Region: Chorismate_bind; cl10555 637382005527 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 637382005528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637382005529 ATP-grasp domain; Region: ATP-grasp; pfam02222 637382005530 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 637382005531 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 637382005532 ATP binding site [chemical binding]; other site 637382005533 Mg++ binding site [ion binding]; other site 637382005534 motif III; other site 637382005535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382005536 nucleotide binding region [chemical binding]; other site 637382005537 ATP-binding site [chemical binding]; other site 637382005538 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 637382005539 YebG protein; Region: YebG; pfam07130 637382005540 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 637382005541 hypothetical protein; Provisional; Region: PRK13680 637382005542 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 637382005543 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637382005544 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 637382005545 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 637382005546 Ferritin-like domain; Region: Ferritin; pfam00210 637382005547 ferroxidase diiron center [ion binding]; other site 637382005548 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 637382005549 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 637382005550 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 637382005551 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 637382005552 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 637382005553 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 637382005554 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 637382005555 FHIPEP family; Region: FHIPEP; pfam00771 637382005556 Flagellar protein FlhE; Region: FlhE; pfam06366 637382005557 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 637382005558 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382005559 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 637382005560 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637382005561 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 637382005562 Invasin, domain 3; Region: Invasin_D3; pfam09134 637382005563 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 637382005564 Flagellar biosynthesis/type III secretory pathway chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3418 637382005565 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 637382005566 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 637382005567 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 637382005568 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 637382005569 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 637382005570 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 637382005571 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637382005572 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637382005573 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 637382005574 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 637382005575 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 637382005576 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 637382005577 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637382005578 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 637382005579 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637382005580 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12643 637382005581 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637382005582 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 637382005583 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 637382005584 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637382005585 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 637382005586 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 637382005587 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 637382005588 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 637382005589 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 637382005590 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 637382005591 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 637382005592 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 637382005593 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 637382005594 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637382005595 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 637382005596 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 637382005597 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637382005598 short chain dehydrogenase; Validated; Region: PRK08324 637382005599 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 637382005600 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 637382005601 putative NAD(P) binding site [chemical binding]; other site 637382005602 active site 637382005603 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382005604 TM-ABC transporter signature motif; other site 637382005605 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 637382005606 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 637382005607 ligand binding site [chemical binding]; other site 637382005608 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637382005609 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382005610 Walker A/P-loop; other site 637382005611 ATP binding site [chemical binding]; other site 637382005612 Q-loop/lid; other site 637382005613 ABC transporter signature motif; other site 637382005614 Walker B; other site 637382005615 D-loop; other site 637382005616 H-loop/switch region; other site 637382005617 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382005618 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382005619 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382005620 TM-ABC transporter signature motif; other site 637382005621 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 637382005622 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637382005623 substrate binding site [chemical binding]; other site 637382005624 ATP binding site [chemical binding]; other site 637382005625 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 637382005626 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 637382005627 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 637382005628 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 637382005629 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 637382005630 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 637382005631 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 637382005632 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 637382005633 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 637382005634 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 637382005635 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 637382005636 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 637382005637 potential frameshift: common BLAST hit: gi|108812457|ref|YP_648224.1| flagellum-specific ATP synthase 637382005638 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637382005639 Walker B motif; other site 637382005640 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637382005641 Walker A motif; other site 637382005642 ATP binding site [chemical binding]; other site 637382005643 flagellar assembly protein H; Validated; Region: fliH; PRK05687 637382005644 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 637382005645 Flagellar assembly protein FliH; Region: FliH; pfam02108 637382005646 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 637382005647 FliG C-terminal domain; Region: FliG_C; pfam01706 637382005648 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 637382005649 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 637382005650 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 637382005651 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 637382005652 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 637382005653 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637382005654 minor groove reading motif; other site 637382005655 helix-hairpin-helix signature motif; other site 637382005656 active site 637382005657 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637382005658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 637382005659 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 637382005660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382005661 flagellar protein FliS; Validated; Region: fliS; PRK05685 637382005662 flagellar capping protein; Reviewed; Region: fliD; PRK08032 637382005663 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 637382005664 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 637382005665 flagellin; Validated; Region: PRK06819 637382005666 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637382005667 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 637382005668 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 637382005669 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637382005670 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637382005671 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637382005672 DNA binding residues [nucleotide binding] 637382005673 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 637382005674 D-cysteine desulfhydrase; Validated; Region: PRK03910 637382005675 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 637382005676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382005677 catalytic residue [active] 637382005678 cystine transporter subunit; Provisional; Region: PRK11260 637382005679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382005680 substrate binding pocket [chemical binding]; other site 637382005681 membrane-bound complex binding site; other site 637382005682 hinge residues; other site 637382005683 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637382005684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382005685 dimer interface [polypeptide binding]; other site 637382005686 conserved gate region; other site 637382005687 putative PBP binding loops; other site 637382005688 ABC-ATPase subunit interface; other site 637382005689 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 637382005690 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637382005691 Walker A/P-loop; other site 637382005692 ATP binding site [chemical binding]; other site 637382005693 Q-loop/lid; other site 637382005694 ABC transporter signature motif; other site 637382005695 Walker B; other site 637382005696 D-loop; other site 637382005697 H-loop/switch region; other site 637382005698 MarR family; Region: MarR_2; cl17246 637382005699 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 637382005700 Predicted transcriptional regulator [Transcription]; Region: COG3905 637382005701 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 637382005702 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 637382005703 Glutamate binding site [chemical binding]; other site 637382005704 NAD binding site [chemical binding]; other site 637382005705 catalytic residues [active] 637382005706 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 637382005707 Na binding site [ion binding]; other site 637382005708 Iron permease FTR1 family; Region: FTR1; cl00475 637382005709 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 637382005710 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 637382005711 Imelysin; Region: Peptidase_M75; pfam09375 637382005712 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 637382005713 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 637382005714 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 637382005715 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637382005716 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 637382005717 Kelch motif; Region: Kelch_1; pfam01344 637382005718 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 637382005719 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 637382005720 GlpM protein; Region: GlpM; pfam06942 637382005721 response regulator; Provisional; Region: PRK09483 637382005722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382005723 active site 637382005724 phosphorylation site [posttranslational modification] 637382005725 intermolecular recognition site; other site 637382005726 dimerization interface [polypeptide binding]; other site 637382005727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382005728 DNA binding residues [nucleotide binding] 637382005729 dimerization interface [polypeptide binding]; other site 637382005730 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 637382005731 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 637382005732 active site 637382005733 catalytic site [active] 637382005734 putative DNA binding site [nucleotide binding]; other site 637382005735 GIY-YIG motif/motif A; other site 637382005736 metal binding site [ion binding]; metal-binding site 637382005737 UvrB/uvrC motif; Region: UVR; pfam02151 637382005738 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 637382005739 Helix-hairpin-helix motif; Region: HHH; pfam00633 637382005740 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 637382005741 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 637382005742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 637382005743 Homeodomain-like domain; Region: HTH_32; pfam13565 637382005744 Integrase core domain; Region: rve; pfam00665 637382005745 Integrase core domain; Region: rve_3; pfam13683 637382005746 Transposase; Region: HTH_Tnp_1; cl17663 637382005747 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 637382005748 TIR domain; Region: TIR_2; pfam13676 637382005749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382005750 MULE transposase domain; Region: MULE; pfam10551 637382005751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382005752 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637382005753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637382005754 DNA-binding site [nucleotide binding]; DNA binding site 637382005755 UTRA domain; Region: UTRA; pfam07702 637382005756 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637382005757 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637382005758 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637382005759 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637382005760 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637382005761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382005762 dimer interface [polypeptide binding]; other site 637382005763 conserved gate region; other site 637382005764 putative PBP binding loops; other site 637382005765 ABC-ATPase subunit interface; other site 637382005766 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637382005767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382005768 dimer interface [polypeptide binding]; other site 637382005769 conserved gate region; other site 637382005770 putative PBP binding loops; other site 637382005771 ABC-ATPase subunit interface; other site 637382005772 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 637382005773 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 637382005774 Walker A/P-loop; other site 637382005775 ATP binding site [chemical binding]; other site 637382005776 Q-loop/lid; other site 637382005777 ABC transporter signature motif; other site 637382005778 Walker B; other site 637382005779 D-loop; other site 637382005780 H-loop/switch region; other site 637382005781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382005782 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382005783 DNA-binding interface [nucleotide binding]; DNA binding site 637382005784 Integrase core domain; Region: rve; pfam00665 637382005785 transposase/IS protein; Provisional; Region: PRK09183 637382005786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382005787 Walker A motif; other site 637382005788 ATP binding site [chemical binding]; other site 637382005789 Walker B motif; other site 637382005790 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 637382005791 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 637382005792 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637382005793 N-terminal plug; other site 637382005794 ligand-binding site [chemical binding]; other site 637382005795 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 637382005796 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 637382005797 acyl-activating enzyme (AAE) consensus motif; other site 637382005798 active site 637382005799 AMP binding site [chemical binding]; other site 637382005800 substrate binding site [chemical binding]; other site 637382005801 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 637382005802 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 637382005803 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637382005804 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 637382005805 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 637382005806 active site 637382005807 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 637382005808 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 637382005809 Methyltransferase domain; Region: Methyltransf_12; pfam08242 637382005810 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 637382005811 KR domain; Region: KR; pfam08659 637382005812 NADP binding site [chemical binding]; other site 637382005813 active site 637382005814 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 637382005815 Condensation domain; Region: Condensation; pfam00668 637382005816 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 637382005817 Nonribosomal peptide synthase; Region: NRPS; pfam08415 637382005818 Methyltransferase domain; Region: Methyltransf_12; pfam08242 637382005819 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 637382005820 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 637382005821 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 637382005822 Condensation domain; Region: Condensation; pfam00668 637382005823 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 637382005824 Nonribosomal peptide synthase; Region: NRPS; pfam08415 637382005825 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 637382005826 acyl-activating enzyme (AAE) consensus motif; other site 637382005827 AMP binding site [chemical binding]; other site 637382005828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382005829 S-adenosylmethionine binding site [chemical binding]; other site 637382005830 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637382005831 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 637382005832 Condensation domain; Region: Condensation; pfam00668 637382005833 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 637382005834 Nonribosomal peptide synthase; Region: NRPS; pfam08415 637382005835 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 637382005836 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637382005837 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382005838 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637382005839 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637382005840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382005841 Walker A/P-loop; other site 637382005842 ATP binding site [chemical binding]; other site 637382005843 Q-loop/lid; other site 637382005844 ABC transporter signature motif; other site 637382005845 Walker B; other site 637382005846 D-loop; other site 637382005847 H-loop/switch region; other site 637382005848 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637382005849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382005850 Walker A/P-loop; other site 637382005851 ATP binding site [chemical binding]; other site 637382005852 Q-loop/lid; other site 637382005853 ABC transporter signature motif; other site 637382005854 Walker B; other site 637382005855 D-loop; other site 637382005856 H-loop/switch region; other site 637382005857 muropeptide transporter; Validated; Region: ampG; cl17669 637382005858 salicylate synthase Irp9; Reviewed; Region: PRK06772 637382005859 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 637382005860 integrase; Provisional; Region: PRK09692 637382005861 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 637382005862 active site 637382005863 Int/Topo IB signature motif; other site 637382005864 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637382005865 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382005866 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637382005867 Fimbrial protein; Region: Fimbrial; cl01416 637382005868 Fimbrial protein; Region: Fimbrial; cl01416 637382005869 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637382005870 PapC N-terminal domain; Region: PapC_N; pfam13954 637382005871 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382005872 PapC C-terminal domain; Region: PapC_C; pfam13953 637382005873 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637382005874 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382005875 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637382005876 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637382005877 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 637382005878 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382005879 substrate binding pocket [chemical binding]; other site 637382005880 membrane-bound complex binding site; other site 637382005881 hinge residues; other site 637382005882 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382005883 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637382005884 substrate binding pocket [chemical binding]; other site 637382005885 membrane-bound complex binding site; other site 637382005886 hinge residues; other site 637382005887 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 637382005888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382005889 dimer interface [polypeptide binding]; other site 637382005890 phosphorylation site [posttranslational modification] 637382005891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382005892 ATP binding site [chemical binding]; other site 637382005893 Mg2+ binding site [ion binding]; other site 637382005894 G-X-G motif; other site 637382005895 Response regulator receiver domain; Region: Response_reg; pfam00072 637382005896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382005897 active site 637382005898 phosphorylation site [posttranslational modification] 637382005899 intermolecular recognition site; other site 637382005900 dimerization interface [polypeptide binding]; other site 637382005901 transcriptional regulator FimZ; Provisional; Region: PRK09935 637382005902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382005903 active site 637382005904 phosphorylation site [posttranslational modification] 637382005905 intermolecular recognition site; other site 637382005906 dimerization interface [polypeptide binding]; other site 637382005907 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382005908 DNA binding residues [nucleotide binding] 637382005909 dimerization interface [polypeptide binding]; other site 637382005910 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 637382005911 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 637382005912 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 637382005913 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 637382005914 putative active site [active] 637382005915 putative catalytic site [active] 637382005916 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 637382005917 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 637382005918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382005919 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 637382005920 putative dimerization interface [polypeptide binding]; other site 637382005921 putative substrate binding pocket [chemical binding]; other site 637382005922 benzoate transport; Region: 2A0115; TIGR00895 637382005923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382005924 putative substrate translocation pore; other site 637382005925 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 637382005926 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 637382005927 active site 637382005928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382005929 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382005930 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637382005931 dimerization interface [polypeptide binding]; other site 637382005932 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK12456 637382005933 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 637382005934 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637382005935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382005936 homodimer interface [polypeptide binding]; other site 637382005937 catalytic residue [active] 637382005938 L-asparagine permease; Provisional; Region: PRK15049 637382005939 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637382005940 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 637382005941 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637382005942 glutaminase; Reviewed; Region: PRK12356 637382005943 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 637382005944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382005945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382005946 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 637382005947 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 637382005948 Predicted membrane protein [Function unknown]; Region: COG4393 637382005949 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 637382005950 Uncharacterized conserved protein [Function unknown]; Region: COG3350 637382005951 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 637382005952 FtsX-like permease family; Region: FtsX; pfam02687 637382005953 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 637382005954 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637382005955 FtsX-like permease family; Region: FtsX; pfam02687 637382005956 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637382005957 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637382005958 Walker A/P-loop; other site 637382005959 ATP binding site [chemical binding]; other site 637382005960 Q-loop/lid; other site 637382005961 ABC transporter signature motif; other site 637382005962 Walker B; other site 637382005963 D-loop; other site 637382005964 H-loop/switch region; other site 637382005965 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 637382005966 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 637382005967 catalytic residues [active] 637382005968 Cytochrome c553 [Energy production and conversion]; Region: COG2863 637382005969 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 637382005970 tellurite resistance protein TehB; Provisional; Region: PRK12335 637382005971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382005972 S-adenosylmethionine binding site [chemical binding]; other site 637382005973 putative endopeptidase; Provisional; Region: PRK14576 637382005974 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 637382005975 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 637382005976 active site 637382005977 outer membrane protein; Provisional; Region: hmsH; PRK14574 637382005978 outer membrane N-deacetylase; Provisional; Region: hmsF; PRK14581 637382005979 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 637382005980 putative active site [active] 637382005981 putative metal binding site [ion binding]; other site 637382005982 N-glycosyltransferase; Provisional; Region: hmsR; PRK14583 637382005983 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 637382005984 DXD motif; other site 637382005985 hemin storage system protein; Provisional; Region: hmsS; PRK14584 637382005986 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637382005987 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637382005988 hypothetical protein; Provisional; Region: PRK10536 637382005989 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 637382005990 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 637382005991 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 637382005992 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 637382005993 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 637382005994 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382005995 dimerization interface [polypeptide binding]; other site 637382005996 Histidine kinase; Region: HisKA_3; pfam07730 637382005997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382005998 ATP binding site [chemical binding]; other site 637382005999 Mg2+ binding site [ion binding]; other site 637382006000 G-X-G motif; other site 637382006001 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637382006002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637382006003 DNA-binding site [nucleotide binding]; DNA binding site 637382006004 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637382006005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382006006 homodimer interface [polypeptide binding]; other site 637382006007 catalytic residue [active] 637382006008 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 637382006009 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637382006010 inhibitor-cofactor binding pocket; inhibition site 637382006011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382006012 catalytic residue [active] 637382006013 arginine succinyltransferase; Provisional; Region: PRK10456 637382006014 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 637382006015 succinylglutamic semialdehyde dehydrogenase; Region: arg_catab_astD; TIGR03240 637382006016 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 637382006017 NAD(P) binding site [chemical binding]; other site 637382006018 catalytic residues [active] 637382006019 succinylarginine dihydrolase; Provisional; Region: PRK13281 637382006020 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 637382006021 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 637382006022 putative active site [active] 637382006023 Zn binding site [ion binding]; other site 637382006024 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 637382006025 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 637382006026 trimer interface [polypeptide binding]; other site 637382006027 eyelet of channel; other site 637382006028 Helix-turn-helix domain; Region: HTH_38; pfam13936 637382006029 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637382006030 Integrase core domain; Region: rve; pfam00665 637382006031 transposase/IS protein; Provisional; Region: PRK09183 637382006032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382006033 Walker A motif; other site 637382006034 ATP binding site [chemical binding]; other site 637382006035 Walker B motif; other site 637382006036 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 637382006037 imidazolonepropionase; Validated; Region: PRK09356 637382006038 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 637382006039 active site 637382006040 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 637382006041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637382006042 DNA-binding site [nucleotide binding]; DNA binding site 637382006043 UTRA domain; Region: UTRA; pfam07702 637382006044 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 637382006045 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 637382006046 active site 637382006047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 637382006048 salicylate synthase; Region: salicyl_syn; TIGR03494 637382006049 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 637382006050 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 637382006051 active site 637382006052 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 637382006053 active site 637382006054 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637382006055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637382006056 NAD(P) binding site [chemical binding]; other site 637382006057 active site 637382006058 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637382006059 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 637382006060 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 637382006061 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 637382006062 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637382006063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637382006064 NAD(P) binding site [chemical binding]; other site 637382006065 active site 637382006066 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637382006067 active site 637382006068 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 637382006069 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 637382006070 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 637382006071 active site 637382006072 TDP-binding site; other site 637382006073 acceptor substrate-binding pocket; other site 637382006074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382006075 MULE transposase domain; Region: MULE; pfam10551 637382006076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 637382006077 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 637382006078 Sel1-like repeats; Region: SEL1; smart00671 637382006079 Sel1-like repeats; Region: SEL1; smart00671 637382006080 Sel1-like repeats; Region: SEL1; smart00671 637382006081 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 637382006082 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 637382006083 Methyltransferase domain; Region: Methyltransf_12; pfam08242 637382006084 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 637382006085 classical (c) SDRs; Region: SDR_c; cd05233 637382006086 NAD(P) binding site [chemical binding]; other site 637382006087 active site 637382006088 HEAT repeats; Region: HEAT_2; pfam13646 637382006089 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 637382006090 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637382006091 catalytic site [active] 637382006092 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 637382006093 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 637382006094 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 637382006095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382006096 dimerization interface [polypeptide binding]; other site 637382006097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382006098 dimer interface [polypeptide binding]; other site 637382006099 phosphorylation site [posttranslational modification] 637382006100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382006101 ATP binding site [chemical binding]; other site 637382006102 Mg2+ binding site [ion binding]; other site 637382006103 G-X-G motif; other site 637382006104 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 637382006105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382006106 active site 637382006107 phosphorylation site [posttranslational modification] 637382006108 intermolecular recognition site; other site 637382006109 dimerization interface [polypeptide binding]; other site 637382006110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382006111 DNA binding site [nucleotide binding] 637382006112 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 637382006113 flavodoxin; Provisional; Region: PRK06934 637382006114 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 637382006115 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 637382006116 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 637382006117 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 637382006118 active site residue [active] 637382006119 Integrase core domain; Region: rve; pfam00665 637382006120 Integrase core domain; Region: rve_3; pfam13683 637382006121 GTP-binding protein YchF; Reviewed; Region: PRK09601 637382006122 YchF GTPase; Region: YchF; cd01900 637382006123 G1 box; other site 637382006124 GTP/Mg2+ binding site [chemical binding]; other site 637382006125 Switch I region; other site 637382006126 G2 box; other site 637382006127 Switch II region; other site 637382006128 G3 box; other site 637382006129 G4 box; other site 637382006130 G5 box; other site 637382006131 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 637382006132 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 637382006133 putative active site [active] 637382006134 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 637382006135 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 637382006136 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637382006137 active site 637382006138 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 637382006139 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637382006140 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 637382006141 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 637382006142 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 637382006143 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 637382006144 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 637382006145 tRNA; other site 637382006146 putative tRNA binding site [nucleotide binding]; other site 637382006147 putative NADP binding site [chemical binding]; other site 637382006148 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 637382006149 peptide chain release factor 1; Validated; Region: prfA; PRK00591 637382006150 This domain is found in peptide chain release factors; Region: PCRF; smart00937 637382006151 RF-1 domain; Region: RF-1; pfam00472 637382006152 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 637382006153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 637382006154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3094 637382006155 hypothetical protein; Provisional; Region: PRK10941 637382006156 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 637382006157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 637382006158 binding surface 637382006159 TPR motif; other site 637382006160 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 637382006161 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 637382006162 potential frameshift: common BLAST hit: gi|294503907|ref|YP_003567969.1| sulfate transporter 637382006163 Sulfate transporter family; Region: Sulfate_transp; pfam00916 637382006164 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 637382006165 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 637382006166 Sulfate transporter family; Region: Sulfate_transp; pfam00916 637382006167 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 637382006168 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 637382006169 putative active site [active] 637382006170 catalytic site [active] 637382006171 putative metal binding site [ion binding]; other site 637382006172 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 637382006173 hypothetical protein; Provisional; Region: PRK11622 637382006174 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 637382006175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382006176 dimer interface [polypeptide binding]; other site 637382006177 conserved gate region; other site 637382006178 putative PBP binding loops; other site 637382006179 ABC-ATPase subunit interface; other site 637382006180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382006181 dimer interface [polypeptide binding]; other site 637382006182 conserved gate region; other site 637382006183 putative PBP binding loops; other site 637382006184 ABC-ATPase subunit interface; other site 637382006185 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 637382006186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382006187 ABC transporter signature motif; other site 637382006188 Walker B; other site 637382006189 D-loop; other site 637382006190 H-loop/switch region; other site 637382006191 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382006192 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 637382006193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382006194 Walker A/P-loop; other site 637382006195 ATP binding site [chemical binding]; other site 637382006196 Q-loop/lid; other site 637382006197 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 637382006198 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 637382006199 active site 637382006200 catalytic site [active] 637382006201 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637382006202 MarR family; Region: MarR_2; pfam12802 637382006203 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637382006204 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637382006205 putative hydrolase; Validated; Region: PRK09248 637382006206 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 637382006207 active site 637382006208 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 637382006209 lipoprotein; Provisional; Region: PRK10598 637382006210 multidrug resistance protein MdtH; Provisional; Region: PRK11646 637382006211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382006212 putative substrate translocation pore; other site 637382006213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 637382006214 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637382006215 hypothetical protein; Provisional; Region: PRK11239 637382006216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 637382006217 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637382006218 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637382006219 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 637382006220 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 637382006221 potential frameshift: common BLAST hit: gi|294503890|ref|YP_003567952.1| putative hemolysin activator protein 637382006222 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 637382006223 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 637382006224 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 637382006225 haemagglutination activity domain; Region: Haemagg_act; smart00912 637382006226 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 637382006227 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382006228 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382006229 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382006230 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382006231 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 637382006232 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 637382006233 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 637382006234 active site 637382006235 HIGH motif; other site 637382006236 KMSK motif region; other site 637382006237 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 637382006238 tRNA binding surface [nucleotide binding]; other site 637382006239 anticodon binding site; other site 637382006240 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 637382006241 putative metal binding site [ion binding]; other site 637382006242 copper homeostasis protein CutC; Provisional; Region: PRK11572 637382006243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382006244 S-adenosylmethionine binding site [chemical binding]; other site 637382006245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382006246 S-adenosylmethionine binding site [chemical binding]; other site 637382006247 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 637382006248 hypothetical protein; Provisional; Region: PRK10302 637382006249 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 637382006250 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 637382006251 dimer interface [polypeptide binding]; other site 637382006252 anticodon binding site; other site 637382006253 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 637382006254 homodimer interface [polypeptide binding]; other site 637382006255 motif 1; other site 637382006256 active site 637382006257 motif 2; other site 637382006258 GAD domain; Region: GAD; pfam02938 637382006259 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637382006260 active site 637382006261 motif 3; other site 637382006262 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 637382006263 nudix motif; other site 637382006264 hypothetical protein; Validated; Region: PRK00110 637382006265 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 637382006266 active site 637382006267 putative DNA-binding cleft [nucleotide binding]; other site 637382006268 dimer interface [polypeptide binding]; other site 637382006269 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 637382006270 RuvA N terminal domain; Region: RuvA_N; pfam01330 637382006271 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 637382006272 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 637382006273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382006274 Walker A motif; other site 637382006275 ATP binding site [chemical binding]; other site 637382006276 Walker B motif; other site 637382006277 arginine finger; other site 637382006278 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 637382006279 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 637382006280 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382006281 ABC-ATPase subunit interface; other site 637382006282 dimer interface [polypeptide binding]; other site 637382006283 putative PBP binding regions; other site 637382006284 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 637382006285 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 637382006286 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 637382006287 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 637382006288 metal binding site [ion binding]; metal-binding site 637382006289 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 637382006290 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637382006291 Peptidase family M23; Region: Peptidase_M23; pfam01551 637382006292 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 637382006293 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 637382006294 putative acyl-acceptor binding pocket; other site 637382006295 pyruvate kinase; Provisional; Region: PRK05826 637382006296 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 637382006297 domain interfaces; other site 637382006298 active site 637382006299 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 637382006300 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637382006301 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637382006302 putative active site [active] 637382006303 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 637382006304 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 637382006305 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 637382006306 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 637382006307 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 637382006308 active site 637382006309 intersubunit interface [polypeptide binding]; other site 637382006310 catalytic residue [active] 637382006311 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 637382006312 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 637382006313 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 637382006314 homotrimer interaction site [polypeptide binding]; other site 637382006315 putative active site [active] 637382006316 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 637382006317 DEAD/DEAH box helicase; Region: DEAD; pfam00270 637382006318 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 637382006319 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 637382006320 Glycoprotease family; Region: Peptidase_M22; pfam00814 637382006321 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 637382006322 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 637382006323 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 637382006324 acyl-activating enzyme (AAE) consensus motif; other site 637382006325 putative AMP binding site [chemical binding]; other site 637382006326 putative active site [active] 637382006327 putative CoA binding site [chemical binding]; other site 637382006328 ribonuclease D; Provisional; Region: PRK10829 637382006329 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 637382006330 catalytic site [active] 637382006331 putative active site [active] 637382006332 putative substrate binding site [chemical binding]; other site 637382006333 HRDC domain; Region: HRDC; pfam00570 637382006334 cell division inhibitor MinD; Provisional; Region: PRK10818 637382006335 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 637382006336 Switch I; other site 637382006337 Switch II; other site 637382006338 septum formation inhibitor; Reviewed; Region: minC; PRK03511 637382006339 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 637382006340 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 637382006341 lytic murein transglycosylase; Region: MltB_2; TIGR02283 637382006342 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637382006343 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637382006344 catalytic residue [active] 637382006345 hypothetical protein; Provisional; Region: PRK10691 637382006346 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 637382006347 hypothetical protein; Provisional; Region: PRK05170 637382006348 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 637382006349 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 637382006350 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 637382006351 Int/Topo IB signature motif; other site 637382006352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382006353 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382006354 DNA-binding interface [nucleotide binding]; DNA binding site 637382006355 Integrase core domain; Region: rve; pfam00665 637382006356 transposase/IS protein; Provisional; Region: PRK09183 637382006357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382006358 Walker A motif; other site 637382006359 ATP binding site [chemical binding]; other site 637382006360 Walker B motif; other site 637382006361 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 637382006362 NinB protein; Region: NinB; pfam05772 637382006363 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 637382006364 Prophage antirepressor [Transcription]; Region: COG3617 637382006365 BRO family, N-terminal domain; Region: Bro-N; smart01040 637382006366 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 637382006367 catalytic residues [active] 637382006368 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 637382006369 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 637382006370 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 637382006371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382006372 MULE transposase domain; Region: MULE; pfam10551 637382006373 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 637382006374 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 637382006375 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 637382006376 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 637382006377 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 637382006378 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 637382006379 Phage tail protein; Region: Phage_tail_3; pfam08813 637382006380 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 637382006381 Phage-related minor tail protein [Function unknown]; Region: COG5281 637382006382 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 637382006383 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 637382006384 Phage-related protein [Function unknown]; Region: COG4718 637382006385 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382006386 Phage-related protein [Function unknown]; Region: gp18; COG4672 637382006387 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 637382006388 MPN+ (JAMM) motif; other site 637382006389 Zinc-binding site [ion binding]; other site 637382006390 NlpC/P60 family; Region: NLPC_P60; pfam00877 637382006391 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 637382006392 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 637382006393 ligand binding surface [chemical binding]; other site 637382006394 Prophage antirepressor [Transcription]; Region: COG3617 637382006395 BRO family, N-terminal domain; Region: Bro-N; smart01040 637382006396 Phage-related protein, tail component [Function unknown]; Region: COG4733 637382006397 Putative phage tail protein; Region: Phage-tail_3; pfam13550 637382006398 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637382006399 Interdomain contacts; other site 637382006400 Cytokine receptor motif; other site 637382006401 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 637382006402 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 637382006403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382006404 MULE transposase domain; Region: MULE; pfam10551 637382006405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382006406 putative substrate translocation pore; other site 637382006407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637382006408 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 637382006409 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 637382006410 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382006411 catalytic residue [active] 637382006412 disulfide bond formation protein B; Provisional; Region: PRK01749 637382006413 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 637382006414 fatty acid metabolism regulator; Provisional; Region: PRK04984 637382006415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637382006416 DNA-binding site [nucleotide binding]; DNA binding site 637382006417 FadR C-terminal domain; Region: FadR_C; pfam07840 637382006418 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 637382006419 SpoVR family protein; Provisional; Region: PRK11767 637382006420 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 637382006421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 637382006422 hydroxyglutarate oxidase; Provisional; Region: PRK11728 637382006423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382006424 putative substrate translocation pore; other site 637382006425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637382006426 Pirin-related protein [General function prediction only]; Region: COG1741 637382006427 Pirin; Region: Pirin; pfam02678 637382006428 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 637382006429 LysR family transcriptional regulator; Provisional; Region: PRK14997 637382006430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382006431 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 637382006432 putative effector binding pocket; other site 637382006433 putative dimerization interface [polypeptide binding]; other site 637382006434 EamA-like transporter family; Region: EamA; pfam00892 637382006435 hypothetical protein; Provisional; Region: PRK05325 637382006436 PrkA family serine protein kinase; Provisional; Region: PRK15455 637382006437 AAA ATPase domain; Region: AAA_16; pfam13191 637382006438 Walker A motif; other site 637382006439 ATP binding site [chemical binding]; other site 637382006440 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 637382006441 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 637382006442 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 637382006443 active site 637382006444 phosphate binding residues; other site 637382006445 catalytic residues [active] 637382006446 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 637382006447 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 637382006448 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 637382006449 methionine sulfoxide reductase B; Provisional; Region: PRK00222 637382006450 SelR domain; Region: SelR; pfam01641 637382006451 Isochorismatase family; Region: Isochorismatase; pfam00857 637382006452 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 637382006453 catalytic triad [active] 637382006454 metal binding site [ion binding]; metal-binding site 637382006455 conserved cis-peptide bond; other site 637382006456 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 637382006457 active site 637382006458 homodimer interface [polypeptide binding]; other site 637382006459 protease 4; Provisional; Region: PRK10949 637382006460 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 637382006461 tandem repeat interface [polypeptide binding]; other site 637382006462 oligomer interface [polypeptide binding]; other site 637382006463 active site residues [active] 637382006464 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 637382006465 tandem repeat interface [polypeptide binding]; other site 637382006466 oligomer interface [polypeptide binding]; other site 637382006467 active site residues [active] 637382006468 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 637382006469 putative FMN binding site [chemical binding]; other site 637382006470 selenophosphate synthetase; Provisional; Region: PRK00943 637382006471 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 637382006472 dimerization interface [polypeptide binding]; other site 637382006473 putative ATP binding site [chemical binding]; other site 637382006474 DNA topoisomerase III; Provisional; Region: PRK07726 637382006475 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 637382006476 active site 637382006477 putative interdomain interaction site [polypeptide binding]; other site 637382006478 putative metal-binding site [ion binding]; other site 637382006479 putative nucleotide binding site [chemical binding]; other site 637382006480 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 637382006481 domain I; other site 637382006482 DNA binding groove [nucleotide binding] 637382006483 phosphate binding site [ion binding]; other site 637382006484 domain II; other site 637382006485 domain III; other site 637382006486 nucleotide binding site [chemical binding]; other site 637382006487 catalytic site [active] 637382006488 domain IV; other site 637382006489 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 637382006490 active site 637382006491 8-oxo-dGMP binding site [chemical binding]; other site 637382006492 nudix motif; other site 637382006493 metal binding site [ion binding]; metal-binding site 637382006494 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 637382006495 putative catalytic site [active] 637382006496 putative phosphate binding site [ion binding]; other site 637382006497 active site 637382006498 metal binding site A [ion binding]; metal-binding site 637382006499 DNA binding site [nucleotide binding] 637382006500 putative AP binding site [nucleotide binding]; other site 637382006501 putative metal binding site B [ion binding]; other site 637382006502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382006503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382006504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382006505 MULE transposase domain; Region: MULE; pfam10551 637382006506 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 637382006507 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 637382006508 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 637382006509 putative active site [active] 637382006510 putative substrate binding site [chemical binding]; other site 637382006511 putative cosubstrate binding site; other site 637382006512 catalytic site [active] 637382006513 SEC-C motif; Region: SEC-C; pfam02810 637382006514 hypothetical protein; Provisional; Region: PRK04233 637382006515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382006516 active site 637382006517 response regulator of RpoS; Provisional; Region: PRK10693 637382006518 phosphorylation site [posttranslational modification] 637382006519 intermolecular recognition site; other site 637382006520 dimerization interface [polypeptide binding]; other site 637382006521 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 637382006522 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 637382006523 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 637382006524 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 637382006525 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 637382006526 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 637382006527 thymidine kinase; Provisional; Region: PRK04296 637382006528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382006529 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637382006530 Walker A motif; other site 637382006531 ATP binding site [chemical binding]; other site 637382006532 Walker B motif; other site 637382006533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382006534 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382006535 DNA-binding interface [nucleotide binding]; DNA binding site 637382006536 Integrase core domain; Region: rve; pfam00665 637382006537 potential frameshift: common BLAST hit: gi|294503776|ref|YP_003567838.1| aldehyde-alcohol dehydrogenase 637382006538 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 637382006539 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 637382006540 catalytic residues [active] 637382006541 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 637382006542 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 637382006543 putative active site [active] 637382006544 metal binding site [ion binding]; metal-binding site 637382006545 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 637382006546 NAD(P) binding site [chemical binding]; other site 637382006547 catalytic residues [active] 637382006548 hypothetical protein; Provisional; Region: PRK11111 637382006549 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 637382006550 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637382006551 peptide binding site [polypeptide binding]; other site 637382006552 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 637382006553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382006554 dimer interface [polypeptide binding]; other site 637382006555 conserved gate region; other site 637382006556 putative PBP binding loops; other site 637382006557 ABC-ATPase subunit interface; other site 637382006558 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 637382006559 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637382006560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382006561 dimer interface [polypeptide binding]; other site 637382006562 conserved gate region; other site 637382006563 ABC-ATPase subunit interface; other site 637382006564 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 637382006565 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382006566 Walker A/P-loop; other site 637382006567 ATP binding site [chemical binding]; other site 637382006568 Q-loop/lid; other site 637382006569 ABC transporter signature motif; other site 637382006570 Walker B; other site 637382006571 D-loop; other site 637382006572 H-loop/switch region; other site 637382006573 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 637382006574 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 637382006575 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382006576 Walker A/P-loop; other site 637382006577 ATP binding site [chemical binding]; other site 637382006578 Q-loop/lid; other site 637382006579 ABC transporter signature motif; other site 637382006580 Walker B; other site 637382006581 D-loop; other site 637382006582 H-loop/switch region; other site 637382006583 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 637382006584 dsDNA-mimic protein; Reviewed; Region: PRK05094 637382006585 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 637382006586 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 637382006587 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 637382006588 putative active site [active] 637382006589 catalytic site [active] 637382006590 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 637382006591 putative active site [active] 637382006592 catalytic site [active] 637382006593 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 637382006594 transport protein TonB; Provisional; Region: PRK10819 637382006595 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 637382006596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382006597 MULE transposase domain; Region: MULE; pfam10551 637382006598 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 637382006599 intracellular septation protein A; Reviewed; Region: PRK00259 637382006600 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 637382006601 Sulfate transporter family; Region: Sulfate_transp; pfam00916 637382006602 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 637382006603 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 637382006604 hypothetical protein; Provisional; Region: PRK02868 637382006605 outer membrane protein W; Provisional; Region: PRK10959 637382006606 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 637382006607 BON domain; Region: BON; pfam04972 637382006608 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 637382006609 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 637382006610 substrate binding site [chemical binding]; other site 637382006611 active site 637382006612 catalytic residues [active] 637382006613 heterodimer interface [polypeptide binding]; other site 637382006614 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 637382006615 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 637382006616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382006617 catalytic residue [active] 637382006618 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 637382006619 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 637382006620 active site 637382006621 ribulose/triose binding site [chemical binding]; other site 637382006622 phosphate binding site [ion binding]; other site 637382006623 substrate (anthranilate) binding pocket [chemical binding]; other site 637382006624 product (indole) binding pocket [chemical binding]; other site 637382006625 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 637382006626 active site 637382006627 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 637382006628 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637382006629 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637382006630 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 637382006631 Glutamine amidotransferase class-I; Region: GATase; pfam00117 637382006632 glutamine binding [chemical binding]; other site 637382006633 catalytic triad [active] 637382006634 anthranilate synthase component I; Provisional; Region: PRK13564 637382006635 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 637382006636 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 637382006637 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 637382006638 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 637382006639 active site 637382006640 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 637382006641 hypothetical protein; Provisional; Region: PRK11630 637382006642 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 637382006643 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637382006644 RNA binding surface [nucleotide binding]; other site 637382006645 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 637382006646 probable active site [active] 637382006647 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 637382006648 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 637382006649 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 637382006650 homodimer interface [polypeptide binding]; other site 637382006651 Walker A motif; other site 637382006652 ATP binding site [chemical binding]; other site 637382006653 hydroxycobalamin binding site [chemical binding]; other site 637382006654 Walker B motif; other site 637382006655 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 637382006656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637382006657 NAD(P) binding site [chemical binding]; other site 637382006658 active site 637382006659 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 637382006660 putative inner membrane peptidase; Provisional; Region: PRK11778 637382006661 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 637382006662 tandem repeat interface [polypeptide binding]; other site 637382006663 oligomer interface [polypeptide binding]; other site 637382006664 active site residues [active] 637382006665 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 637382006666 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 637382006667 active site 637382006668 interdomain interaction site; other site 637382006669 putative metal-binding site [ion binding]; other site 637382006670 nucleotide binding site [chemical binding]; other site 637382006671 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 637382006672 domain I; other site 637382006673 DNA binding groove [nucleotide binding] 637382006674 phosphate binding site [ion binding]; other site 637382006675 domain II; other site 637382006676 domain III; other site 637382006677 nucleotide binding site [chemical binding]; other site 637382006678 catalytic site [active] 637382006679 domain IV; other site 637382006680 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637382006681 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637382006682 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 637382006683 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 637382006684 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 637382006685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382006686 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 637382006687 substrate binding site [chemical binding]; other site 637382006688 putative dimerization interface [polypeptide binding]; other site 637382006689 aconitate hydratase; Validated; Region: PRK09277 637382006690 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 637382006691 substrate binding site [chemical binding]; other site 637382006692 ligand binding site [chemical binding]; other site 637382006693 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 637382006694 substrate binding site [chemical binding]; other site 637382006695 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 637382006696 dimerization interface [polypeptide binding]; other site 637382006697 active site 637382006698 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 637382006699 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 637382006700 active site 637382006701 Predicted membrane protein [Function unknown]; Region: COG3771 637382006702 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 637382006703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637382006704 TPR motif; other site 637382006705 binding surface 637382006706 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 637382006707 active site 637382006708 dimer interface [polypeptide binding]; other site 637382006709 translation initiation factor Sui1; Validated; Region: PRK06824 637382006710 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 637382006711 putative rRNA binding site [nucleotide binding]; other site 637382006712 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 637382006713 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 637382006714 intersubunit interface [polypeptide binding]; other site 637382006715 active site 637382006716 Zn2+ binding site [ion binding]; other site 637382006717 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 637382006718 active site 637382006719 intersubunit interactions; other site 637382006720 catalytic residue [active] 637382006721 Uncharacterized small protein [Function unknown]; Region: COG2879 637382006722 carbon starvation protein A; Provisional; Region: PRK15015 637382006723 Carbon starvation protein CstA; Region: CstA; pfam02554 637382006724 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 637382006725 exoribonuclease II; Provisional; Region: PRK05054 637382006726 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 637382006727 RNB domain; Region: RNB; pfam00773 637382006728 S1 RNA binding domain; Region: S1; pfam00575 637382006729 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 637382006730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382006731 putative substrate translocation pore; other site 637382006732 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637382006733 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 637382006734 putative NAD(P) binding site [chemical binding]; other site 637382006735 active site 637382006736 putative substrate binding site [chemical binding]; other site 637382006737 endonuclease III; Provisional; Region: PRK10702 637382006738 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637382006739 minor groove reading motif; other site 637382006740 helix-hairpin-helix signature motif; other site 637382006741 substrate binding pocket [chemical binding]; other site 637382006742 active site 637382006743 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 637382006744 electron transport complex RsxE subunit; Provisional; Region: PRK12405 637382006745 electron transport complex protein RnfG; Validated; Region: PRK01908 637382006746 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 637382006747 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637382006748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382006749 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 637382006750 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 637382006751 SLBB domain; Region: SLBB; pfam10531 637382006752 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637382006753 electron transport complex protein RnfB; Provisional; Region: PRK05113 637382006754 Putative Fe-S cluster; Region: FeS; pfam04060 637382006755 4Fe-4S binding domain; Region: Fer4; pfam00037 637382006756 electron transport complex protein RsxA; Provisional; Region: PRK05151 637382006757 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 637382006758 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 637382006759 putative active site [active] 637382006760 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637382006761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382006762 Walker A/P-loop; other site 637382006763 ATP binding site [chemical binding]; other site 637382006764 Q-loop/lid; other site 637382006765 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 637382006766 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382006767 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382006768 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 637382006769 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 637382006770 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637382006771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382006772 Walker A/P-loop; other site 637382006773 ATP binding site [chemical binding]; other site 637382006774 Q-loop/lid; other site 637382006775 ABC transporter signature motif; other site 637382006776 Walker B; other site 637382006777 D-loop; other site 637382006778 H-loop/switch region; other site 637382006779 L-arabinose isomerase; Provisional; Region: PRK02929 637382006780 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 637382006781 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 637382006782 trimer interface [polypeptide binding]; other site 637382006783 putative substrate binding site [chemical binding]; other site 637382006784 putative metal binding site [ion binding]; other site 637382006785 ribulokinase; Provisional; Region: PRK04123 637382006786 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 637382006787 N- and C-terminal domain interface [polypeptide binding]; other site 637382006788 active site 637382006789 MgATP binding site [chemical binding]; other site 637382006790 catalytic site [active] 637382006791 metal binding site [ion binding]; metal-binding site 637382006792 carbohydrate binding site [chemical binding]; other site 637382006793 homodimer interface [polypeptide binding]; other site 637382006794 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 637382006795 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 637382006796 ligand binding site [chemical binding]; other site 637382006797 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 637382006798 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382006799 Walker A/P-loop; other site 637382006800 ATP binding site [chemical binding]; other site 637382006801 Q-loop/lid; other site 637382006802 ABC transporter signature motif; other site 637382006803 Walker B; other site 637382006804 D-loop; other site 637382006805 H-loop/switch region; other site 637382006806 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382006807 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382006808 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382006809 TM-ABC transporter signature motif; other site 637382006810 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 637382006811 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637382006812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382006813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382006814 putative oxidoreductase; Provisional; Region: PRK11579 637382006815 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637382006816 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637382006817 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 637382006818 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 637382006819 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 637382006820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 637382006821 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 637382006822 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 637382006823 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 637382006824 fumarate hydratase; Reviewed; Region: fumC; PRK00485 637382006825 Class II fumarases; Region: Fumarase_classII; cd01362 637382006826 active site 637382006827 tetramer interface [polypeptide binding]; other site 637382006828 DNA replication terminus site-binding protein; Region: rep_term_tus; TIGR02648 637382006829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382006830 putative substrate translocation pore; other site 637382006831 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 637382006832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382006833 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 637382006834 dimerization interface [polypeptide binding]; other site 637382006835 substrate binding pocket [chemical binding]; other site 637382006836 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 637382006837 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637382006838 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637382006839 nucleotide binding site [chemical binding]; other site 637382006840 putative dithiobiotin synthetase; Provisional; Region: PRK12374 637382006841 AAA domain; Region: AAA_26; pfam13500 637382006842 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 637382006843 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 637382006844 Cl- selectivity filter; other site 637382006845 Cl- binding residues [ion binding]; other site 637382006846 pore gating glutamate residue; other site 637382006847 dimer interface [polypeptide binding]; other site 637382006848 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637382006849 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382006850 DNA binding site [nucleotide binding] 637382006851 domain linker motif; other site 637382006852 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 637382006853 dimerization interface (closed form) [polypeptide binding]; other site 637382006854 ligand binding site [chemical binding]; other site 637382006855 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 637382006856 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637382006857 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 637382006858 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 637382006859 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637382006860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382006861 dimer interface [polypeptide binding]; other site 637382006862 conserved gate region; other site 637382006863 putative PBP binding loops; other site 637382006864 ABC-ATPase subunit interface; other site 637382006865 AMP nucleosidase; Provisional; Region: PRK08292 637382006866 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 637382006867 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 637382006868 Protein of unknown function (DUF1602); Region: DUF1602; pfam07673 637382006869 ribonuclease E; Reviewed; Region: rne; PRK10811 637382006870 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 637382006871 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 637382006872 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 637382006873 G1 box; other site 637382006874 GTP/Mg2+ binding site [chemical binding]; other site 637382006875 G2 box; other site 637382006876 Switch I region; other site 637382006877 G3 box; other site 637382006878 Switch II region; other site 637382006879 G4 box; other site 637382006880 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 637382006881 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 637382006882 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637382006883 PYR/PP interface [polypeptide binding]; other site 637382006884 dimer interface [polypeptide binding]; other site 637382006885 TPP binding site [chemical binding]; other site 637382006886 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637382006887 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 637382006888 TPP-binding site [chemical binding]; other site 637382006889 dimer interface [polypeptide binding]; other site 637382006890 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 637382006891 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 637382006892 putative valine binding site [chemical binding]; other site 637382006893 dimer interface [polypeptide binding]; other site 637382006894 dUMP phosphatase; Provisional; Region: PRK09449 637382006895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382006896 motif II; other site 637382006897 tellurite resistance protein terB; Region: terB; cd07176 637382006898 putative metal binding site [ion binding]; other site 637382006899 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 637382006900 alkaline phosphatase; Provisional; Region: PRK10518 637382006901 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 637382006902 dimer interface [polypeptide binding]; other site 637382006903 active site 637382006904 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 637382006905 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 637382006906 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637382006907 DNA binding site [nucleotide binding] 637382006908 active site 637382006909 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 637382006910 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637382006911 ligand binding site [chemical binding]; other site 637382006912 flexible hinge region; other site 637382006913 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 637382006914 putative switch regulator; other site 637382006915 non-specific DNA interactions [nucleotide binding]; other site 637382006916 DNA binding site [nucleotide binding] 637382006917 sequence specific DNA binding site [nucleotide binding]; other site 637382006918 putative cAMP binding site [chemical binding]; other site 637382006919 universal stress protein UspE; Provisional; Region: PRK11175 637382006920 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637382006921 Ligand Binding Site [chemical binding]; other site 637382006922 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637382006923 Ligand Binding Site [chemical binding]; other site 637382006924 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 637382006925 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 637382006926 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 637382006927 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 637382006928 ligand binding site [chemical binding]; other site 637382006929 homodimer interface [polypeptide binding]; other site 637382006930 NAD(P) binding site [chemical binding]; other site 637382006931 trimer interface B [polypeptide binding]; other site 637382006932 trimer interface A [polypeptide binding]; other site 637382006933 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 637382006934 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 637382006935 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 637382006936 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 637382006937 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 637382006938 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 637382006939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382006940 active site 637382006941 phosphorylation site [posttranslational modification] 637382006942 intermolecular recognition site; other site 637382006943 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382006944 DNA binding site [nucleotide binding] 637382006945 sensor protein RstB; Provisional; Region: PRK10604 637382006946 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382006947 dimerization interface [polypeptide binding]; other site 637382006948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382006949 dimer interface [polypeptide binding]; other site 637382006950 phosphorylation site [posttranslational modification] 637382006951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382006952 ATP binding site [chemical binding]; other site 637382006953 Mg2+ binding site [ion binding]; other site 637382006954 G-X-G motif; other site 637382006955 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 637382006956 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 637382006957 active site 637382006958 Zn binding site [ion binding]; other site 637382006959 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382006960 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637382006961 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637382006962 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 637382006963 hypothetical protein; Provisional; Region: PRK03757 637382006964 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 637382006965 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 637382006966 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637382006967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637382006968 non-specific DNA binding site [nucleotide binding]; other site 637382006969 salt bridge; other site 637382006970 sequence-specific DNA binding site [nucleotide binding]; other site 637382006971 Phage-related protein [Function unknown]; Region: COG4679 637382006972 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 637382006973 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637382006974 ATP binding site [chemical binding]; other site 637382006975 putative Mg++ binding site [ion binding]; other site 637382006976 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382006977 nucleotide binding region [chemical binding]; other site 637382006978 ATP-binding site [chemical binding]; other site 637382006979 Helicase associated domain (HA2); Region: HA2; pfam04408 637382006980 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 637382006981 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 637382006982 azoreductase; Reviewed; Region: PRK00170 637382006983 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637382006984 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 637382006985 MarR family; Region: MarR_2; pfam12802 637382006986 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637382006987 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 637382006988 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 637382006989 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 637382006990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 637382006991 hypothetical protein; Provisional; Region: PRK10695 637382006992 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 637382006993 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 637382006994 putative ligand binding site [chemical binding]; other site 637382006995 putative NAD binding site [chemical binding]; other site 637382006996 catalytic site [active] 637382006997 heat-inducible protein; Provisional; Region: PRK10449 637382006998 Domain of unknown function (DUF333); Region: DUF333; pfam03891 637382006999 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 637382007000 MgtC family; Region: MgtC; pfam02308 637382007001 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 637382007002 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 637382007003 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 637382007004 dimer interface [polypeptide binding]; other site 637382007005 PYR/PP interface [polypeptide binding]; other site 637382007006 TPP binding site [chemical binding]; other site 637382007007 substrate binding site [chemical binding]; other site 637382007008 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 637382007009 Domain of unknown function; Region: EKR; pfam10371 637382007010 4Fe-4S binding domain; Region: Fer4_6; pfam12837 637382007011 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637382007012 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 637382007013 TPP-binding site [chemical binding]; other site 637382007014 dimer interface [polypeptide binding]; other site 637382007015 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 637382007016 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 637382007017 Ligand Binding Site [chemical binding]; other site 637382007018 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 637382007019 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 637382007020 substrate binding pocket [chemical binding]; other site 637382007021 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637382007022 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637382007023 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 637382007024 DNA binding residues [nucleotide binding] 637382007025 dimer interface [polypeptide binding]; other site 637382007026 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 637382007027 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 637382007028 Cl binding site [ion binding]; other site 637382007029 oligomer interface [polypeptide binding]; other site 637382007030 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 637382007031 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637382007032 peptide binding site [polypeptide binding]; other site 637382007033 murein peptide amidase A; Provisional; Region: PRK10602 637382007034 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 637382007035 active site 637382007036 Zn binding site [ion binding]; other site 637382007037 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 637382007038 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 637382007039 active site 637382007040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382007041 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382007042 DNA-binding interface [nucleotide binding]; DNA binding site 637382007043 Integrase core domain; Region: rve; pfam00665 637382007044 transposase/IS protein; Provisional; Region: PRK09183 637382007045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382007046 Walker A motif; other site 637382007047 ATP binding site [chemical binding]; other site 637382007048 Walker B motif; other site 637382007049 Patatin-like phospholipase; Region: Patatin; pfam01734 637382007050 nucleophile elbow; other site 637382007051 alanine racemase; Reviewed; Region: PRK13340 637382007052 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826 637382007053 active site 637382007054 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637382007055 dimer interface [polypeptide binding]; other site 637382007056 substrate binding site [chemical binding]; other site 637382007057 catalytic residues [active] 637382007058 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 637382007059 YadA-like C-terminal region; Region: YadA; pfam03895 637382007060 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 637382007061 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 637382007062 trimer interface [polypeptide binding]; other site 637382007063 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 637382007064 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637382007065 amidase catalytic site [active] 637382007066 Zn binding residues [ion binding]; other site 637382007067 substrate binding site [chemical binding]; other site 637382007068 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637382007069 chemotaxis regulator CheZ; Provisional; Region: PRK11166 637382007070 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 637382007071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382007072 active site 637382007073 phosphorylation site [posttranslational modification] 637382007074 intermolecular recognition site; other site 637382007075 dimerization interface [polypeptide binding]; other site 637382007076 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 637382007077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382007078 active site 637382007079 phosphorylation site [posttranslational modification] 637382007080 intermolecular recognition site; other site 637382007081 dimerization interface [polypeptide binding]; other site 637382007082 CheB methylesterase; Region: CheB_methylest; pfam01339 637382007083 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 637382007084 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 637382007085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382007086 methyl-accepting protein IV; Provisional; Region: PRK09793 637382007087 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 637382007088 dimer interface [polypeptide binding]; other site 637382007089 ligand binding site [chemical binding]; other site 637382007090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382007091 dimerization interface [polypeptide binding]; other site 637382007092 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637382007093 dimer interface [polypeptide binding]; other site 637382007094 putative CheW interface [polypeptide binding]; other site 637382007095 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 637382007096 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 637382007097 dimer interface [polypeptide binding]; other site 637382007098 ligand binding site [chemical binding]; other site 637382007099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382007100 dimerization interface [polypeptide binding]; other site 637382007101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637382007102 dimer interface [polypeptide binding]; other site 637382007103 putative CheW interface [polypeptide binding]; other site 637382007104 hypothetical protein; Provisional; Region: PRK10215 637382007105 Predicted membrane protein [Function unknown]; Region: COG5373 637382007106 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637382007107 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637382007108 Autotransporter beta-domain; Region: Autotransporter; smart00869 637382007109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 637382007110 YheO-like PAS domain; Region: PAS_6; pfam08348 637382007111 HTH domain; Region: HTH_22; pfam13309 637382007112 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 637382007113 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 637382007114 homotrimer interaction site [polypeptide binding]; other site 637382007115 putative active site [active] 637382007116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382007117 putative substrate translocation pore; other site 637382007118 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 637382007119 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 637382007120 putative CheA interaction surface; other site 637382007121 chemotaxis protein CheA; Provisional; Region: PRK10547 637382007122 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637382007123 putative binding surface; other site 637382007124 active site 637382007125 CheY binding; Region: CheY-binding; pfam09078 637382007126 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 637382007127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382007128 ATP binding site [chemical binding]; other site 637382007129 Mg2+ binding site [ion binding]; other site 637382007130 G-X-G motif; other site 637382007131 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 637382007132 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 637382007133 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 637382007134 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637382007135 ligand binding site [chemical binding]; other site 637382007136 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 637382007137 flagellar motor protein MotA; Validated; Region: PRK09110 637382007138 transcriptional activator FlhC; Provisional; Region: PRK12722 637382007139 magnesium-transporting ATPase; Provisional; Region: PRK15122 637382007140 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 637382007141 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637382007142 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 637382007143 Soluble P-type ATPase [General function prediction only]; Region: COG4087 637382007144 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 637382007145 magnesium transport protein MgtC; Provisional; Region: PRK15385 637382007146 MgtC family; Region: MgtC; pfam02308 637382007147 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 637382007148 dimer interface [polypeptide binding]; other site 637382007149 ligand binding site [chemical binding]; other site 637382007150 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382007151 dimerization interface [polypeptide binding]; other site 637382007152 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637382007153 dimer interface [polypeptide binding]; other site 637382007154 putative CheW interface [polypeptide binding]; other site 637382007155 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637382007156 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 637382007157 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 637382007158 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 637382007159 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 637382007160 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 637382007161 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 637382007162 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 637382007163 NAD(P) binding site [chemical binding]; other site 637382007164 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 637382007165 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 637382007166 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 637382007167 putative DNA binding site [nucleotide binding]; other site 637382007168 putative Zn2+ binding site [ion binding]; other site 637382007169 AsnC family; Region: AsnC_trans_reg; pfam01037 637382007170 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 637382007171 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 637382007172 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 637382007173 catalytic core [active] 637382007174 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 637382007175 Predicted transcriptional regulators [Transcription]; Region: COG1733 637382007176 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 637382007177 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 637382007178 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 637382007179 NADP binding site [chemical binding]; other site 637382007180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637382007181 PAS domain; Region: PAS_9; pfam13426 637382007182 putative active site [active] 637382007183 heme pocket [chemical binding]; other site 637382007184 HAMP domain; Region: HAMP; pfam00672 637382007185 dimerization interface [polypeptide binding]; other site 637382007186 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637382007187 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637382007188 dimer interface [polypeptide binding]; other site 637382007189 putative CheW interface [polypeptide binding]; other site 637382007190 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637382007191 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382007192 DNA binding site [nucleotide binding] 637382007193 domain linker motif; other site 637382007194 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 637382007195 putative dimerization interface [polypeptide binding]; other site 637382007196 putative ligand binding site [chemical binding]; other site 637382007197 isocitrate dehydrogenase; Validated; Region: PRK07362 637382007198 isocitrate dehydrogenase; Reviewed; Region: PRK07006 637382007199 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 637382007200 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 637382007201 probable active site [active] 637382007202 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 637382007203 nudix motif; other site 637382007204 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 637382007205 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 637382007206 putative lysogenization regulator; Reviewed; Region: PRK00218 637382007207 adenylosuccinate lyase; Provisional; Region: PRK09285 637382007208 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 637382007209 tetramer interface [polypeptide binding]; other site 637382007210 active site 637382007211 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 637382007212 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 637382007213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382007214 active site 637382007215 phosphorylation site [posttranslational modification] 637382007216 intermolecular recognition site; other site 637382007217 dimerization interface [polypeptide binding]; other site 637382007218 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382007219 DNA binding site [nucleotide binding] 637382007220 sensor protein PhoQ; Provisional; Region: PRK10815 637382007221 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 637382007222 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 637382007223 dimer interface [polypeptide binding]; other site 637382007224 phosphorylation site [posttranslational modification] 637382007225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382007226 ATP binding site [chemical binding]; other site 637382007227 Mg2+ binding site [ion binding]; other site 637382007228 G-X-G motif; other site 637382007229 Uncharacterized conserved protein [Function unknown]; Region: COG2850 637382007230 Cupin-like domain; Region: Cupin_8; pfam13621 637382007231 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 637382007232 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 637382007233 metal binding site [ion binding]; metal-binding site 637382007234 dimer interface [polypeptide binding]; other site 637382007235 NAD-dependent deacetylase; Provisional; Region: PRK00481 637382007236 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 637382007237 NAD+ binding site [chemical binding]; other site 637382007238 substrate binding site [chemical binding]; other site 637382007239 Zn binding site [ion binding]; other site 637382007240 fructokinase; Reviewed; Region: PRK09557 637382007241 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637382007242 nucleotide binding site [chemical binding]; other site 637382007243 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 637382007244 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637382007245 FtsX-like permease family; Region: FtsX; pfam02687 637382007246 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 637382007247 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637382007248 Walker A/P-loop; other site 637382007249 ATP binding site [chemical binding]; other site 637382007250 Q-loop/lid; other site 637382007251 ABC transporter signature motif; other site 637382007252 Walker B; other site 637382007253 D-loop; other site 637382007254 H-loop/switch region; other site 637382007255 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 637382007256 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637382007257 FtsX-like permease family; Region: FtsX; pfam02687 637382007258 transcription-repair coupling factor; Provisional; Region: PRK10689 637382007259 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 637382007260 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637382007261 ATP binding site [chemical binding]; other site 637382007262 putative Mg++ binding site [ion binding]; other site 637382007263 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382007264 nucleotide binding region [chemical binding]; other site 637382007265 ATP-binding site [chemical binding]; other site 637382007266 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 637382007267 hypothetical protein; Provisional; Region: PRK11280 637382007268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382007269 MULE transposase domain; Region: MULE; pfam10551 637382007270 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 637382007271 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637382007272 hypothetical protein; Provisional; Region: PRK04940 637382007273 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 637382007274 beta-hexosaminidase; Provisional; Region: PRK05337 637382007275 thiamine kinase; Region: ycfN_thiK; TIGR02721 637382007276 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 637382007277 active site 637382007278 substrate binding site [chemical binding]; other site 637382007279 ATP binding site [chemical binding]; other site 637382007280 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 637382007281 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 637382007282 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 637382007283 putative dimer interface [polypeptide binding]; other site 637382007284 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 637382007285 nucleotide binding site/active site [active] 637382007286 HIT family signature motif; other site 637382007287 catalytic residue [active] 637382007288 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 637382007289 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 637382007290 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 637382007291 shikimate binding site; other site 637382007292 NAD(P) binding site [chemical binding]; other site 637382007293 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382007294 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 637382007295 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637382007296 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637382007297 active site turn [active] 637382007298 phosphorylation site [posttranslational modification] 637382007299 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 637382007300 active site 637382007301 DNA polymerase III subunit delta'; Validated; Region: PRK07993 637382007302 DNA polymerase III subunit delta'; Validated; Region: PRK08485 637382007303 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 637382007304 thymidylate kinase; Validated; Region: tmk; PRK00698 637382007305 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 637382007306 TMP-binding site; other site 637382007307 ATP-binding site [chemical binding]; other site 637382007308 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 637382007309 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 637382007310 dimerization interface [polypeptide binding]; other site 637382007311 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 637382007312 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 637382007313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382007314 catalytic residue [active] 637382007315 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382007316 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 637382007317 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637382007318 dimer interface [polypeptide binding]; other site 637382007319 active site 637382007320 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 637382007321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637382007322 active site 637382007323 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 637382007324 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 637382007325 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 637382007326 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 637382007327 dimer interface [polypeptide binding]; other site 637382007328 active site 637382007329 CoA binding pocket [chemical binding]; other site 637382007330 Fatty acid/phospholipid biosynthesis enzyme [Lipid metabolism]; Region: PlsX; COG0416 637382007331 hypothetical protein; Provisional; Region: PRK11193 637382007332 Maf-like protein; Region: Maf; pfam02545 637382007333 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 637382007334 active site 637382007335 dimer interface [polypeptide binding]; other site 637382007336 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382007337 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 637382007338 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637382007339 RNA binding surface [nucleotide binding]; other site 637382007340 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637382007341 active site 637382007342 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 637382007343 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 637382007344 homodimer interface [polypeptide binding]; other site 637382007345 oligonucleotide binding site [chemical binding]; other site 637382007346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382007347 MULE transposase domain; Region: MULE; pfam10551 637382007348 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 637382007349 active site 637382007350 substrate binding pocket [chemical binding]; other site 637382007351 dimer interface [polypeptide binding]; other site 637382007352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382007353 MULE transposase domain; Region: MULE; pfam10551 637382007354 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 637382007355 hydroxyglutarate oxidase; Provisional; Region: PRK11728 637382007356 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 637382007357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382007358 DNA binding residues [nucleotide binding] 637382007359 dimerization interface [polypeptide binding]; other site 637382007360 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 637382007361 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637382007362 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 637382007363 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 637382007364 active site residue [active] 637382007365 EamA-like transporter family; Region: EamA; pfam00892 637382007366 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 637382007367 Autoinducer synthetase; Region: Autoind_synth; pfam00765 637382007368 Autoinducer binding domain; Region: Autoind_bind; pfam03472 637382007369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382007370 DNA binding residues [nucleotide binding] 637382007371 dimerization interface [polypeptide binding]; other site 637382007372 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 637382007373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382007374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637382007375 dimerization interface [polypeptide binding]; other site 637382007376 benzoate transport; Region: 2A0115; TIGR00895 637382007377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382007378 putative substrate translocation pore; other site 637382007379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382007380 Formaldehyde-activating enzyme nesessary for methanogenesis [Energy production and conversion]; Region: COG1795 637382007381 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637382007382 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637382007383 active site 637382007384 catalytic tetrad [active] 637382007385 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09674 637382007386 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 637382007387 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09676 637382007388 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09675 637382007389 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 637382007390 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 637382007391 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 637382007392 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 637382007393 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637382007394 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 637382007395 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 637382007396 active site 637382007397 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637382007398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382007399 dimer interface [polypeptide binding]; other site 637382007400 conserved gate region; other site 637382007401 putative PBP binding loops; other site 637382007402 ABC-ATPase subunit interface; other site 637382007403 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 637382007404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382007405 dimer interface [polypeptide binding]; other site 637382007406 putative PBP binding loops; other site 637382007407 ABC-ATPase subunit interface; other site 637382007408 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637382007409 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637382007410 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637382007411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382007412 DNA binding site [nucleotide binding] 637382007413 domain linker motif; other site 637382007414 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 637382007415 putative dimerization interface [polypeptide binding]; other site 637382007416 putative ligand binding site [chemical binding]; other site 637382007417 phosphomannomutase CpsG; Provisional; Region: PRK15414 637382007418 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 637382007419 active site 637382007420 substrate binding site [chemical binding]; other site 637382007421 metal binding site [ion binding]; metal-binding site 637382007422 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 637382007423 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 637382007424 Walker A/P-loop; other site 637382007425 ATP binding site [chemical binding]; other site 637382007426 Q-loop/lid; other site 637382007427 ABC transporter signature motif; other site 637382007428 Walker B; other site 637382007429 D-loop; other site 637382007430 H-loop/switch region; other site 637382007431 TOBE domain; Region: TOBE_2; pfam08402 637382007432 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 637382007433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4304 637382007434 haemagglutination activity domain; Region: Haemagg_act; pfam05860 637382007435 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 637382007436 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382007437 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382007438 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382007439 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 637382007440 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 637382007441 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 637382007442 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 637382007443 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 637382007444 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 637382007445 FMN-binding pocket [chemical binding]; other site 637382007446 flavin binding motif; other site 637382007447 phosphate binding motif [ion binding]; other site 637382007448 beta-alpha-beta structure motif; other site 637382007449 NAD binding pocket [chemical binding]; other site 637382007450 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637382007451 catalytic loop [active] 637382007452 iron binding site [ion binding]; other site 637382007453 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 637382007454 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 637382007455 [2Fe-2S] cluster binding site [ion binding]; other site 637382007456 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 637382007457 putative alpha subunit interface [polypeptide binding]; other site 637382007458 putative active site [active] 637382007459 putative substrate binding site [chemical binding]; other site 637382007460 Fe binding site [ion binding]; other site 637382007461 putative transporter; Provisional; Region: PRK09950 637382007462 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 637382007463 tartrate dehydrogenase; Region: TTC; TIGR02089 637382007464 transcriptional activator TtdR; Provisional; Region: PRK09801 637382007465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382007466 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 637382007467 putative effector binding pocket; other site 637382007468 putative dimerization interface [polypeptide binding]; other site 637382007469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637382007470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382007471 DNA binding site [nucleotide binding] 637382007472 domain linker motif; other site 637382007473 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637382007474 dimerization interface [polypeptide binding]; other site 637382007475 ligand binding site [chemical binding]; other site 637382007476 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382007477 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382007478 TM-ABC transporter signature motif; other site 637382007479 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637382007480 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382007481 Walker A/P-loop; other site 637382007482 ATP binding site [chemical binding]; other site 637382007483 Q-loop/lid; other site 637382007484 ABC transporter signature motif; other site 637382007485 Walker B; other site 637382007486 D-loop; other site 637382007487 H-loop/switch region; other site 637382007488 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382007489 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 637382007490 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 637382007491 putative ligand binding site [chemical binding]; other site 637382007492 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637382007493 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 637382007494 putative NAD(P) binding site [chemical binding]; other site 637382007495 catalytic Zn binding site [ion binding]; other site 637382007496 structural Zn binding site [ion binding]; other site 637382007497 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 637382007498 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: COG3965 637382007499 outer membrane protein X; Provisional; Region: ompX; PRK09408 637382007500 threonine and homoserine efflux system; Provisional; Region: PRK10532 637382007501 putative acetyltransferase YhhY; Provisional; Region: PRK10140 637382007502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637382007503 Coenzyme A binding pocket [chemical binding]; other site 637382007504 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 637382007505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382007506 S-adenosylmethionine binding site [chemical binding]; other site 637382007507 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 637382007508 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 637382007509 dimerization interface [polypeptide binding]; other site 637382007510 DPS ferroxidase diiron center [ion binding]; other site 637382007511 ion pore; other site 637382007512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637382007513 TPR motif; other site 637382007514 binding surface 637382007515 Uncharacterized conserved protein [Function unknown]; Region: COG1434 637382007516 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637382007517 putative active site [active] 637382007518 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 637382007519 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382007520 substrate binding pocket [chemical binding]; other site 637382007521 membrane-bound complex binding site; other site 637382007522 hinge residues; other site 637382007523 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637382007524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382007525 dimer interface [polypeptide binding]; other site 637382007526 conserved gate region; other site 637382007527 putative PBP binding loops; other site 637382007528 ABC-ATPase subunit interface; other site 637382007529 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 637382007530 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637382007531 Walker A/P-loop; other site 637382007532 ATP binding site [chemical binding]; other site 637382007533 Q-loop/lid; other site 637382007534 ABC transporter signature motif; other site 637382007535 Walker B; other site 637382007536 D-loop; other site 637382007537 H-loop/switch region; other site 637382007538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637382007539 PAS domain; Region: PAS_9; pfam13426 637382007540 putative active site [active] 637382007541 heme pocket [chemical binding]; other site 637382007542 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637382007543 PAS domain; Region: PAS_9; pfam13426 637382007544 putative active site [active] 637382007545 heme pocket [chemical binding]; other site 637382007546 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637382007547 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637382007548 dimer interface [polypeptide binding]; other site 637382007549 putative CheW interface [polypeptide binding]; other site 637382007550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382007551 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382007552 DNA-binding interface [nucleotide binding]; DNA binding site 637382007553 Integrase core domain; Region: rve; pfam00665 637382007554 transposase/IS protein; Provisional; Region: PRK09183 637382007555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382007556 Walker A motif; other site 637382007557 ATP binding site [chemical binding]; other site 637382007558 Walker B motif; other site 637382007559 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 637382007560 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 637382007561 active site 637382007562 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 637382007563 active site 637382007564 catalytic residues [active] 637382007565 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 637382007566 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 637382007567 Putative methyltransferase; Region: Methyltransf_20; pfam12147 637382007568 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 637382007569 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637382007570 putative acyl-acceptor binding pocket; other site 637382007571 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 637382007572 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 637382007573 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 637382007574 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 637382007575 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 637382007576 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 637382007577 homodimer interface [polypeptide binding]; other site 637382007578 NADP binding site [chemical binding]; other site 637382007579 substrate binding site [chemical binding]; other site 637382007580 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382007581 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637382007582 active site 637382007583 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 637382007584 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 637382007585 dimerization interface [polypeptide binding]; other site 637382007586 putative ATP binding site [chemical binding]; other site 637382007587 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 637382007588 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 637382007589 active site 637382007590 substrate binding site [chemical binding]; other site 637382007591 cosubstrate binding site; other site 637382007592 catalytic site [active] 637382007593 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 637382007594 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637382007595 Flagellin N-methylase; Region: FliB; pfam03692 637382007596 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 637382007597 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 637382007598 Walker A/P-loop; other site 637382007599 ATP binding site [chemical binding]; other site 637382007600 Q-loop/lid; other site 637382007601 ABC transporter signature motif; other site 637382007602 Walker B; other site 637382007603 D-loop; other site 637382007604 H-loop/switch region; other site 637382007605 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 637382007606 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 637382007607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382007608 dimer interface [polypeptide binding]; other site 637382007609 conserved gate region; other site 637382007610 putative PBP binding loops; other site 637382007611 ABC-ATPase subunit interface; other site 637382007612 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 637382007613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382007614 conserved gate region; other site 637382007615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382007616 dimer interface [polypeptide binding]; other site 637382007617 conserved gate region; other site 637382007618 putative PBP binding loops; other site 637382007619 ABC-ATPase subunit interface; other site 637382007620 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 637382007621 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 637382007622 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 637382007623 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 637382007624 putative active site [active] 637382007625 catalytic site [active] 637382007626 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 637382007627 domain interface [polypeptide binding]; other site 637382007628 active site 637382007629 catalytic site [active] 637382007630 exopolyphosphatase; Provisional; Region: PRK10854 637382007631 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637382007632 nucleotide binding site [chemical binding]; other site 637382007633 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 637382007634 MgtE intracellular N domain; Region: MgtE_N; smart00924 637382007635 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 637382007636 Divalent cation transporter; Region: MgtE; cl00786 637382007637 putative chaperone; Provisional; Region: PRK11678 637382007638 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 637382007639 nucleotide binding site [chemical binding]; other site 637382007640 putative NEF/HSP70 interaction site [polypeptide binding]; other site 637382007641 SBD interface [polypeptide binding]; other site 637382007642 potential frameshift: common BLAST hit: gi|294504592|ref|YP_003568654.1| putative ABC transporter permease 637382007643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382007644 ABC-ATPase subunit interface; other site 637382007645 putative PBP binding loops; other site 637382007646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 637382007647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382007648 dimer interface [polypeptide binding]; other site 637382007649 conserved gate region; other site 637382007650 putative PBP binding loops; other site 637382007651 ABC-ATPase subunit interface; other site 637382007652 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 637382007653 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637382007654 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 637382007655 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637382007656 inhibitor-cofactor binding pocket; inhibition site 637382007657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382007658 catalytic residue [active] 637382007659 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637382007660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637382007661 DNA-binding site [nucleotide binding]; DNA binding site 637382007662 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637382007663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382007664 homodimer interface [polypeptide binding]; other site 637382007665 catalytic residue [active] 637382007666 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 637382007667 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 637382007668 Walker A/P-loop; other site 637382007669 ATP binding site [chemical binding]; other site 637382007670 Q-loop/lid; other site 637382007671 ABC transporter signature motif; other site 637382007672 Walker B; other site 637382007673 D-loop; other site 637382007674 H-loop/switch region; other site 637382007675 TOBE domain; Region: TOBE_2; pfam08402 637382007676 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 637382007677 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382007678 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382007679 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 637382007680 Protein export membrane protein; Region: SecD_SecF; cl14618 637382007681 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 637382007682 Protein export membrane protein; Region: SecD_SecF; cl14618 637382007683 putative transporter; Provisional; Region: PRK10504 637382007684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382007685 putative substrate translocation pore; other site 637382007686 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 637382007687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382007688 dimerization interface [polypeptide binding]; other site 637382007689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382007690 dimer interface [polypeptide binding]; other site 637382007691 phosphorylation site [posttranslational modification] 637382007692 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 637382007693 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 637382007694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382007695 active site 637382007696 phosphorylation site [posttranslational modification] 637382007697 intermolecular recognition site; other site 637382007698 dimerization interface [polypeptide binding]; other site 637382007699 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382007700 DNA binding site [nucleotide binding] 637382007701 Uncharacterized conserved protein [Function unknown]; Region: COG3422 637382007702 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 637382007703 putative protease; Provisional; Region: PRK15452 637382007704 Peptidase family U32; Region: Peptidase_U32; pfam01136 637382007705 lipid kinase; Reviewed; Region: PRK13054 637382007706 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 637382007707 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 637382007708 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 637382007709 substrate binding site [chemical binding]; other site 637382007710 dimer interface [polypeptide binding]; other site 637382007711 ATP binding site [chemical binding]; other site 637382007712 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 637382007713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382007714 MULE transposase domain; Region: MULE; pfam10551 637382007715 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 637382007716 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 637382007717 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 637382007718 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382007719 GMP synthase; Reviewed; Region: guaA; PRK00074 637382007720 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 637382007721 AMP/PPi binding site [chemical binding]; other site 637382007722 candidate oxyanion hole; other site 637382007723 catalytic triad [active] 637382007724 potential glutamine specificity residues [chemical binding]; other site 637382007725 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 637382007726 ATP Binding subdomain [chemical binding]; other site 637382007727 Ligand Binding sites [chemical binding]; other site 637382007728 Dimerization subdomain; other site 637382007729 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 637382007730 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 637382007731 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 637382007732 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 637382007733 active site 637382007734 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 637382007735 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 637382007736 generic binding surface II; other site 637382007737 generic binding surface I; other site 637382007738 Predicted permeases [General function prediction only]; Region: COG0679 637382007739 GTP-binding protein Der; Reviewed; Region: PRK00093 637382007740 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 637382007741 G1 box; other site 637382007742 GTP/Mg2+ binding site [chemical binding]; other site 637382007743 Switch I region; other site 637382007744 G2 box; other site 637382007745 Switch II region; other site 637382007746 G3 box; other site 637382007747 G4 box; other site 637382007748 G5 box; other site 637382007749 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 637382007750 G1 box; other site 637382007751 GTP/Mg2+ binding site [chemical binding]; other site 637382007752 Switch I region; other site 637382007753 G2 box; other site 637382007754 G3 box; other site 637382007755 Switch II region; other site 637382007756 G4 box; other site 637382007757 G5 box; other site 637382007758 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 637382007759 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 637382007760 Trp docking motif [polypeptide binding]; other site 637382007761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 637382007762 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 637382007763 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 637382007764 dimer interface [polypeptide binding]; other site 637382007765 motif 1; other site 637382007766 active site 637382007767 motif 2; other site 637382007768 motif 3; other site 637382007769 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 637382007770 anticodon binding site; other site 637382007771 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 637382007772 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 637382007773 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 637382007774 cytoskeletal protein RodZ; Provisional; Region: PRK10856 637382007775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637382007776 non-specific DNA binding site [nucleotide binding]; other site 637382007777 salt bridge; other site 637382007778 sequence-specific DNA binding site [nucleotide binding]; other site 637382007779 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 637382007780 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 637382007781 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 637382007782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382007783 FeS/SAM binding site; other site 637382007784 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 637382007785 active site 637382007786 multimer interface [polypeptide binding]; other site 637382007787 Protein of unkown function (DUF1881); Region: DUF1881; pfam08964 637382007788 Beta/Gamma crystallin; Region: Crystall; cl02528 637382007789 Beta/Gamma crystallin; Region: Crystall; cl02528 637382007790 Exotoxin A binding; Region: Exotox-A_bind; pfam09101 637382007791 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 637382007792 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 637382007793 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637382007794 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637382007795 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 637382007796 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637382007797 Autotransporter beta-domain; Region: Autotransporter; smart00869 637382007798 SseB protein; Region: SseB; pfam07179 637382007799 aminopeptidase B; Provisional; Region: PRK05015 637382007800 Peptidase; Region: DUF3663; pfam12404 637382007801 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 637382007802 interface (dimer of trimers) [polypeptide binding]; other site 637382007803 Substrate-binding/catalytic site; other site 637382007804 Zn-binding sites [ion binding]; other site 637382007805 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 637382007806 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637382007807 catalytic loop [active] 637382007808 iron binding site [ion binding]; other site 637382007809 chaperone protein HscA; Provisional; Region: hscA; PRK05183 637382007810 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 637382007811 nucleotide binding site [chemical binding]; other site 637382007812 putative NEF/HSP70 interaction site [polypeptide binding]; other site 637382007813 SBD interface [polypeptide binding]; other site 637382007814 co-chaperone HscB; Provisional; Region: hscB; PRK05014 637382007815 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 637382007816 HSP70 interaction site [polypeptide binding]; other site 637382007817 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 637382007818 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 637382007819 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 637382007820 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 637382007821 trimerization site [polypeptide binding]; other site 637382007822 active site 637382007823 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637382007824 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637382007825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382007826 catalytic residue [active] 637382007827 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 637382007828 Rrf2 family protein; Region: rrf2_super; TIGR00738 637382007829 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 637382007830 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 637382007831 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 637382007832 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 637382007833 active site 637382007834 dimerization interface [polypeptide binding]; other site 637382007835 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382007836 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 637382007837 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 637382007838 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 637382007839 PRD domain; Region: PRD; pfam00874 637382007840 potential frameshift: common BLAST hit: gi|294504536|ref|YP_003568598.1| putative transport permease 637382007841 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 637382007842 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 637382007843 MFS_1 like family; Region: MFS_1_like; pfam12832 637382007844 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 637382007845 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 637382007846 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 637382007847 dimer interface [polypeptide binding]; other site 637382007848 active site 637382007849 glycine-pyridoxal phosphate binding site [chemical binding]; other site 637382007850 folate binding site [chemical binding]; other site 637382007851 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 637382007852 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 637382007853 heme-binding site [chemical binding]; other site 637382007854 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 637382007855 FAD binding pocket [chemical binding]; other site 637382007856 FAD binding motif [chemical binding]; other site 637382007857 phosphate binding motif [ion binding]; other site 637382007858 beta-alpha-beta structure motif; other site 637382007859 NAD binding pocket [chemical binding]; other site 637382007860 Heme binding pocket [chemical binding]; other site 637382007861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637382007862 DNA-binding site [nucleotide binding]; DNA binding site 637382007863 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 637382007864 Nitrogen regulatory protein P-II; Region: P-II; smart00938 637382007865 NAD synthetase; Provisional; Region: PRK13981 637382007866 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 637382007867 multimer interface [polypeptide binding]; other site 637382007868 active site 637382007869 catalytic triad [active] 637382007870 protein interface 1 [polypeptide binding]; other site 637382007871 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 637382007872 homodimer interface [polypeptide binding]; other site 637382007873 NAD binding pocket [chemical binding]; other site 637382007874 ATP binding pocket [chemical binding]; other site 637382007875 Mg binding site [ion binding]; other site 637382007876 active-site loop [active] 637382007877 response regulator GlrR; Provisional; Region: PRK15115 637382007878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382007879 active site 637382007880 phosphorylation site [posttranslational modification] 637382007881 intermolecular recognition site; other site 637382007882 dimerization interface [polypeptide binding]; other site 637382007883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382007884 Walker A motif; other site 637382007885 ATP binding site [chemical binding]; other site 637382007886 Walker B motif; other site 637382007887 arginine finger; other site 637382007888 hypothetical protein; Provisional; Region: PRK10722 637382007889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637382007890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382007891 dimer interface [polypeptide binding]; other site 637382007892 phosphorylation site [posttranslational modification] 637382007893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382007894 ATP binding site [chemical binding]; other site 637382007895 Mg2+ binding site [ion binding]; other site 637382007896 G-X-G motif; other site 637382007897 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382007898 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 637382007899 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 637382007900 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 637382007901 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 637382007902 dimerization interface [polypeptide binding]; other site 637382007903 ATP binding site [chemical binding]; other site 637382007904 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 637382007905 dimerization interface [polypeptide binding]; other site 637382007906 ATP binding site [chemical binding]; other site 637382007907 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 637382007908 putative active site [active] 637382007909 catalytic triad [active] 637382007910 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 637382007911 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382007912 substrate binding pocket [chemical binding]; other site 637382007913 membrane-bound complex binding site; other site 637382007914 hinge residues; other site 637382007915 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637382007916 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637382007917 catalytic residue [active] 637382007918 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 637382007919 nucleoside/Zn binding site; other site 637382007920 dimer interface [polypeptide binding]; other site 637382007921 catalytic motif [active] 637382007922 haloacid dehalogenase superfamily, subfamily IF hydrolase, YfhB; Region: YfhB_g-proteo; TIGR01545 637382007923 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 637382007924 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 637382007925 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 637382007926 putative active site [active] 637382007927 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637382007928 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 637382007929 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637382007930 putative active site [active] 637382007931 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382007932 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 637382007933 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 637382007934 active site 637382007935 hydrophilic channel; other site 637382007936 dimerization interface [polypeptide binding]; other site 637382007937 catalytic residues [active] 637382007938 active site lid [active] 637382007939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382007940 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637382007941 Walker A motif; other site 637382007942 ATP binding site [chemical binding]; other site 637382007943 Walker B motif; other site 637382007944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382007945 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382007946 DNA-binding interface [nucleotide binding]; DNA binding site 637382007947 Integrase core domain; Region: rve; pfam00665 637382007948 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 637382007949 Recombination protein O N terminal; Region: RecO_N; pfam11967 637382007950 Recombination protein O C terminal; Region: RecO_C; pfam02565 637382007951 GTPase Era; Reviewed; Region: era; PRK00089 637382007952 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 637382007953 G1 box; other site 637382007954 GTP/Mg2+ binding site [chemical binding]; other site 637382007955 Switch I region; other site 637382007956 G2 box; other site 637382007957 Switch II region; other site 637382007958 G3 box; other site 637382007959 G4 box; other site 637382007960 G5 box; other site 637382007961 KH domain; Region: KH_2; pfam07650 637382007962 ribonuclease III; Reviewed; Region: rnc; PRK00102 637382007963 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 637382007964 dimerization interface [polypeptide binding]; other site 637382007965 active site 637382007966 metal binding site [ion binding]; metal-binding site 637382007967 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 637382007968 dsRNA binding site [nucleotide binding]; other site 637382007969 signal peptidase I; Provisional; Region: PRK10861 637382007970 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637382007971 Catalytic site [active] 637382007972 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637382007973 GTP-binding protein LepA; Provisional; Region: PRK05433 637382007974 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 637382007975 G1 box; other site 637382007976 putative GEF interaction site [polypeptide binding]; other site 637382007977 GTP/Mg2+ binding site [chemical binding]; other site 637382007978 Switch I region; other site 637382007979 G2 box; other site 637382007980 G3 box; other site 637382007981 Switch II region; other site 637382007982 G4 box; other site 637382007983 G5 box; other site 637382007984 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 637382007985 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 637382007986 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 637382007987 SoxR reducing system protein RseC; Provisional; Region: PRK10862 637382007988 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 637382007989 anti-sigma E factor; Provisional; Region: rseB; PRK09455 637382007990 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 637382007991 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 637382007992 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 637382007993 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 637382007994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637382007995 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637382007996 DNA binding residues [nucleotide binding] 637382007997 L-aspartate oxidase; Provisional; Region: PRK09077 637382007998 L-aspartate oxidase; Provisional; Region: PRK06175 637382007999 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 637382008000 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 637382008001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382008002 S-adenosylmethionine binding site [chemical binding]; other site 637382008003 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 637382008004 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 637382008005 ATP binding site [chemical binding]; other site 637382008006 Mg++ binding site [ion binding]; other site 637382008007 motif III; other site 637382008008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382008009 nucleotide binding region [chemical binding]; other site 637382008010 ATP-binding site [chemical binding]; other site 637382008011 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 637382008012 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 637382008013 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 637382008014 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 637382008015 nucleophilic elbow; other site 637382008016 catalytic triad; other site 637382008017 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 637382008018 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 637382008019 ligand binding site [chemical binding]; other site 637382008020 active site 637382008021 UGI interface [polypeptide binding]; other site 637382008022 catalytic site [active] 637382008023 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 637382008024 putative substrate binding pocket [chemical binding]; other site 637382008025 AC domain interface; other site 637382008026 catalytic triad [active] 637382008027 AB domain interface; other site 637382008028 interchain disulfide; other site 637382008029 Predicted membrane protein [Function unknown]; Region: COG3817 637382008030 Protein of unknown function (DUF979); Region: DUF979; pfam06166 637382008031 Predicted membrane protein [Function unknown]; Region: COG3819 637382008032 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 637382008033 putative active site [active] 637382008034 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 637382008035 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 637382008036 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 637382008037 Uncharacterized conserved protein [Function unknown]; Region: COG0327 637382008038 metal-binding protein; Provisional; Region: PRK10799 637382008039 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 637382008040 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 637382008041 DNA photolyase; Region: DNA_photolyase; pfam00875 637382008042 hypothetical protein; Provisional; Region: PRK10167 637382008043 Uncharacterized conserved protein [Function unknown]; Region: COG3272 637382008044 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 637382008045 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 637382008046 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637382008047 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 637382008048 sensor protein KdpD; Provisional; Region: PRK10490 637382008049 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 637382008050 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 637382008051 Ligand Binding Site [chemical binding]; other site 637382008052 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 637382008053 GAF domain; Region: GAF_3; pfam13492 637382008054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382008055 dimer interface [polypeptide binding]; other site 637382008056 phosphorylation site [posttranslational modification] 637382008057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382008058 ATP binding site [chemical binding]; other site 637382008059 Mg2+ binding site [ion binding]; other site 637382008060 G-X-G motif; other site 637382008061 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 637382008062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382008063 active site 637382008064 phosphorylation site [posttranslational modification] 637382008065 intermolecular recognition site; other site 637382008066 dimerization interface [polypeptide binding]; other site 637382008067 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382008068 DNA binding site [nucleotide binding] 637382008069 Predicted membrane protein [Function unknown]; Region: COG2510 637382008070 phosphoglucomutase; Validated; Region: PRK07564 637382008071 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 637382008072 active site 637382008073 substrate binding site [chemical binding]; other site 637382008074 metal binding site [ion binding]; metal-binding site 637382008075 replication initiation regulator SeqA; Provisional; Region: PRK11187 637382008076 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 637382008077 putative active site [active] 637382008078 YdjC motif; other site 637382008079 Mg binding site [ion binding]; other site 637382008080 putative homodimer interface [polypeptide binding]; other site 637382008081 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 637382008082 Cupin domain; Region: Cupin_2; cl17218 637382008083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382008084 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637382008085 methionine cluster; other site 637382008086 active site 637382008087 phosphorylation site [posttranslational modification] 637382008088 metal binding site [ion binding]; metal-binding site 637382008089 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 637382008090 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 637382008091 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 637382008092 active site 637382008093 P-loop; other site 637382008094 phosphorylation site [posttranslational modification] 637382008095 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 637382008096 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636 637382008097 voltage-gated potassium channel; Provisional; Region: PRK10537 637382008098 Ion channel; Region: Ion_trans_2; pfam07885 637382008099 TrkA-N domain; Region: TrkA_N; pfam02254 637382008100 acid-resistance protein; Provisional; Region: hdeB; PRK11566 637382008101 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 637382008102 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 637382008103 UreD urease accessory protein; Region: UreD; pfam01774 637382008104 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378 637382008105 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 637382008106 UreF; Region: UreF; pfam01730 637382008107 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 637382008108 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 637382008109 dimer interface [polypeptide binding]; other site 637382008110 catalytic residues [active] 637382008111 urease subunit alpha; Reviewed; Region: ureC; PRK13309 637382008112 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 637382008113 subunit interactions [polypeptide binding]; other site 637382008114 active site 637382008115 flap region; other site 637382008116 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 637382008117 alpha-beta subunit interface [polypeptide binding]; other site 637382008118 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 637382008119 alpha-gamma subunit interface [polypeptide binding]; other site 637382008120 beta-gamma subunit interface [polypeptide binding]; other site 637382008121 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 637382008122 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382008123 Walker A/P-loop; other site 637382008124 ATP binding site [chemical binding]; other site 637382008125 Q-loop/lid; other site 637382008126 ABC transporter signature motif; other site 637382008127 Walker B; other site 637382008128 D-loop; other site 637382008129 H-loop/switch region; other site 637382008130 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382008131 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 637382008132 Walker A/P-loop; other site 637382008133 ATP binding site [chemical binding]; other site 637382008134 Q-loop/lid; other site 637382008135 ABC transporter signature motif; other site 637382008136 Walker B; other site 637382008137 D-loop; other site 637382008138 H-loop/switch region; other site 637382008139 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637382008140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382008141 dimer interface [polypeptide binding]; other site 637382008142 conserved gate region; other site 637382008143 putative PBP binding loops; other site 637382008144 ABC-ATPase subunit interface; other site 637382008145 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637382008146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382008147 dimer interface [polypeptide binding]; other site 637382008148 conserved gate region; other site 637382008149 putative PBP binding loops; other site 637382008150 ABC-ATPase subunit interface; other site 637382008151 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 637382008152 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 637382008153 MbeD/MobD like; Region: MbeD_MobD; pfam04899 637382008154 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 637382008155 hypothetical protein; Provisional; Region: PRK10556 637382008156 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 637382008157 potential frameshift: common BLAST hit: gi|294504448|ref|YP_003568510.1| ribonucleotide-diphosphate reductase subunit alpha 637382008158 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 637382008159 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 637382008160 Class I ribonucleotide reductase; Region: RNR_I; cd01679 637382008161 active site 637382008162 dimer interface [polypeptide binding]; other site 637382008163 catalytic residues [active] 637382008164 effector binding site; other site 637382008165 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 637382008166 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 637382008167 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 637382008168 dimer interface [polypeptide binding]; other site 637382008169 putative radical transfer pathway; other site 637382008170 diiron center [ion binding]; other site 637382008171 tyrosyl radical; other site 637382008172 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 637382008173 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 637382008174 Walker A/P-loop; other site 637382008175 ATP binding site [chemical binding]; other site 637382008176 Q-loop/lid; other site 637382008177 ABC transporter signature motif; other site 637382008178 Walker B; other site 637382008179 D-loop; other site 637382008180 H-loop/switch region; other site 637382008181 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 637382008182 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 637382008183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382008184 dimer interface [polypeptide binding]; other site 637382008185 conserved gate region; other site 637382008186 putative PBP binding loops; other site 637382008187 ABC-ATPase subunit interface; other site 637382008188 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 637382008189 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 637382008190 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 637382008191 tetramer interface [polypeptide binding]; other site 637382008192 active site 637382008193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382008194 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382008195 DNA-binding interface [nucleotide binding]; DNA binding site 637382008196 Integrase core domain; Region: rve; pfam00665 637382008197 transposase/IS protein; Provisional; Region: PRK09183 637382008198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382008199 Walker A motif; other site 637382008200 ATP binding site [chemical binding]; other site 637382008201 Walker B motif; other site 637382008202 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637382008203 acyl-CoA esterase; Provisional; Region: PRK10673 637382008204 PGAP1-like protein; Region: PGAP1; pfam07819 637382008205 flavodoxin FldA; Validated; Region: PRK09267 637382008206 ferric uptake regulator; Provisional; Region: fur; PRK09462 637382008207 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 637382008208 metal binding site 2 [ion binding]; metal-binding site 637382008209 putative DNA binding helix; other site 637382008210 metal binding site 1 [ion binding]; metal-binding site 637382008211 dimer interface [polypeptide binding]; other site 637382008212 structural Zn2+ binding site [ion binding]; other site 637382008213 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 637382008214 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 637382008215 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 637382008216 active site 637382008217 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 637382008218 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 637382008219 outer membrane porin, OprD family; Region: OprD; pfam03573 637382008220 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 637382008221 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637382008222 active site 637382008223 HIGH motif; other site 637382008224 nucleotide binding site [chemical binding]; other site 637382008225 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 637382008226 KMSKS motif; other site 637382008227 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 637382008228 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382008229 potential frameshift: common BLAST hit: gi|218929709|ref|YP_002347584.1| pts system, N-acetylglucosamine-specific IIABC component 637382008230 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637382008231 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 637382008232 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637382008233 active site turn [active] 637382008234 phosphorylation site [posttranslational modification] 637382008235 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 637382008236 HPr interaction site; other site 637382008237 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637382008238 active site 637382008239 phosphorylation site [posttranslational modification] 637382008240 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637382008241 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 637382008242 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 637382008243 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 637382008244 active site 637382008245 trimer interface [polypeptide binding]; other site 637382008246 allosteric site; other site 637382008247 active site lid [active] 637382008248 hexamer (dimer of trimers) interface [polypeptide binding]; other site 637382008249 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 637382008250 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 637382008251 active site 637382008252 dimer interface [polypeptide binding]; other site 637382008253 MarR family; Region: MarR; pfam01047 637382008254 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637382008255 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637382008256 nucleotide binding site [chemical binding]; other site 637382008257 UMP phosphatase; Provisional; Region: PRK10444 637382008258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382008259 active site 637382008260 motif I; other site 637382008261 motif II; other site 637382008262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382008263 asparagine synthetase B; Provisional; Region: asnB; PRK09431 637382008264 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 637382008265 active site 637382008266 dimer interface [polypeptide binding]; other site 637382008267 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 637382008268 Ligand Binding Site [chemical binding]; other site 637382008269 Molecular Tunnel; other site 637382008270 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 637382008271 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 637382008272 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 637382008273 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 637382008274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382008275 FeS/SAM binding site; other site 637382008276 TRAM domain; Region: TRAM; pfam01938 637382008277 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 637382008278 PhoH-like protein; Region: PhoH; pfam02562 637382008279 metal-binding heat shock protein; Provisional; Region: PRK00016 637382008280 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 637382008281 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637382008282 Transporter associated domain; Region: CorC_HlyC; smart01091 637382008283 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 637382008284 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 637382008285 putative active site [active] 637382008286 catalytic triad [active] 637382008287 putative dimer interface [polypeptide binding]; other site 637382008288 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 637382008289 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382008290 substrate binding pocket [chemical binding]; other site 637382008291 membrane-bound complex binding site; other site 637382008292 hinge residues; other site 637382008293 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637382008294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382008295 dimer interface [polypeptide binding]; other site 637382008296 conserved gate region; other site 637382008297 putative PBP binding loops; other site 637382008298 ABC-ATPase subunit interface; other site 637382008299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382008300 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637382008301 dimer interface [polypeptide binding]; other site 637382008302 conserved gate region; other site 637382008303 putative PBP binding loops; other site 637382008304 ABC-ATPase subunit interface; other site 637382008305 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637382008306 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637382008307 Walker A/P-loop; other site 637382008308 ATP binding site [chemical binding]; other site 637382008309 Q-loop/lid; other site 637382008310 ABC transporter signature motif; other site 637382008311 Walker B; other site 637382008312 D-loop; other site 637382008313 H-loop/switch region; other site 637382008314 hypothetical protein; Provisional; Region: PRK11032 637382008315 Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488 637382008316 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 637382008317 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 637382008318 HIGH motif; other site 637382008319 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 637382008320 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637382008321 active site 637382008322 KMSKS motif; other site 637382008323 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 637382008324 tRNA binding surface [nucleotide binding]; other site 637382008325 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 637382008326 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 637382008327 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 637382008328 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 637382008329 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 637382008330 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 637382008331 active site 637382008332 (T/H)XGH motif; other site 637382008333 ribosome-associated protein; Provisional; Region: PRK11538 637382008334 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 637382008335 penicillin-binding protein 2; Provisional; Region: PRK10795 637382008336 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637382008337 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 637382008338 cell wall shape-determining protein; Provisional; Region: PRK10794 637382008339 potential frameshift: common BLAST hit: gi|218929683|ref|YP_002347558.1| rare lipoprotein A 637382008340 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 637382008341 Sporulation related domain; Region: SPOR; pfam05036 637382008342 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 637382008343 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 637382008344 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 637382008345 lipoate-protein ligase B; Provisional; Region: PRK14342 637382008346 lipoyl synthase; Provisional; Region: PRK05481 637382008347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382008348 FeS/SAM binding site; other site 637382008349 chromosome condensation membrane protein; Provisional; Region: PRK14196 637382008350 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 637382008351 DNA-binding site [nucleotide binding]; DNA binding site 637382008352 RNA-binding motif; other site 637382008353 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637382008354 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382008355 DNA binding residues [nucleotide binding] 637382008356 dimerization interface [polypeptide binding]; other site 637382008357 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 637382008358 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637382008359 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 637382008360 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 637382008361 Walker A/P-loop; other site 637382008362 ATP binding site [chemical binding]; other site 637382008363 Q-loop/lid; other site 637382008364 ABC transporter signature motif; other site 637382008365 Walker B; other site 637382008366 D-loop; other site 637382008367 H-loop/switch region; other site 637382008368 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 637382008369 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 637382008370 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 637382008371 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637382008372 substrate binding site [chemical binding]; other site 637382008373 ATP binding site [chemical binding]; other site 637382008374 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 637382008375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 637382008376 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637382008377 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637382008378 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382008379 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382008380 TM-ABC transporter signature motif; other site 637382008381 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637382008382 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382008383 Walker A/P-loop; other site 637382008384 ATP binding site [chemical binding]; other site 637382008385 Q-loop/lid; other site 637382008386 ABC transporter signature motif; other site 637382008387 Walker B; other site 637382008388 D-loop; other site 637382008389 H-loop/switch region; other site 637382008390 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382008391 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 637382008392 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 637382008393 ligand binding site [chemical binding]; other site 637382008394 potential frameshift: common BLAST hit: gi|186894450|ref|YP_001871562.1| oxidoreductase domain-containing protein 637382008395 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637382008396 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637382008397 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637382008398 Domain of unknown function (DUF1886); Region: DUF1886; cl01666 637382008399 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 637382008400 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637382008401 PYR/PP interface [polypeptide binding]; other site 637382008402 dimer interface [polypeptide binding]; other site 637382008403 TPP binding site [chemical binding]; other site 637382008404 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637382008405 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 637382008406 TPP-binding site; other site 637382008407 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 637382008408 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 637382008409 tetrameric interface [polypeptide binding]; other site 637382008410 NAD binding site [chemical binding]; other site 637382008411 catalytic residues [active] 637382008412 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637382008413 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637382008414 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637382008415 putative active site [active] 637382008416 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 637382008417 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 637382008418 MG2 domain; Region: A2M_N; pfam01835 637382008419 Alpha-2-macroglobulin family; Region: A2M; pfam00207 637382008420 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 637382008421 surface patch; other site 637382008422 thioester region; other site 637382008423 specificity defining residues; other site 637382008424 Transglycosylase; Region: Transgly; pfam00912 637382008425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382008426 MULE transposase domain; Region: MULE; pfam10551 637382008427 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637382008428 active site 637382008429 phosphorylation site [posttranslational modification] 637382008430 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637382008431 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382008432 DNA binding site [nucleotide binding] 637382008433 domain linker motif; other site 637382008434 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 637382008435 putative dimerization interface [polypeptide binding]; other site 637382008436 putative ligand binding site [chemical binding]; other site 637382008437 phosphate acetyltransferase; Reviewed; Region: PRK05632 637382008438 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637382008439 DRTGG domain; Region: DRTGG; pfam07085 637382008440 phosphate acetyltransferase; Region: pta; TIGR00651 637382008441 propionate/acetate kinase; Provisional; Region: PRK12379 637382008442 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 637382008443 hypothetical protein; Provisional; Region: PRK01816 637382008444 hypothetical protein; Validated; Region: PRK05445 637382008445 putative phosphatase; Provisional; Region: PRK11587 637382008446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382008447 motif II; other site 637382008448 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 637382008449 transmembrane helices; other site 637382008450 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 637382008451 TrkA-C domain; Region: TrkA_C; pfam02080 637382008452 TrkA-C domain; Region: TrkA_C; pfam02080 637382008453 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 637382008454 5'-nucleotidase; Provisional; Region: PRK03826 637382008455 aminotransferase AlaT; Validated; Region: PRK09265 637382008456 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637382008457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382008458 homodimer interface [polypeptide binding]; other site 637382008459 catalytic residue [active] 637382008460 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 637382008461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382008462 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 637382008463 putative dimerization interface [polypeptide binding]; other site 637382008464 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 637382008465 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 637382008466 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 637382008467 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 637382008468 NADH dehydrogenase subunit D; Validated; Region: PRK06075 637382008469 NADH dehydrogenase subunit E; Validated; Region: PRK07539 637382008470 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 637382008471 putative dimer interface [polypeptide binding]; other site 637382008472 [2Fe-2S] cluster binding site [ion binding]; other site 637382008473 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 637382008474 SLBB domain; Region: SLBB; pfam10531 637382008475 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 637382008476 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 637382008477 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637382008478 catalytic loop [active] 637382008479 iron binding site [ion binding]; other site 637382008480 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 637382008481 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 637382008482 [4Fe-4S] binding site [ion binding]; other site 637382008483 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 637382008484 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 637382008485 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 637382008486 4Fe-4S binding domain; Region: Fer4; pfam00037 637382008487 4Fe-4S binding domain; Region: Fer4; pfam00037 637382008488 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 637382008489 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 637382008490 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 637382008491 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 637382008492 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 637382008493 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 637382008494 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 637382008495 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 637382008496 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 637382008497 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 637382008498 RNA polymerase I-specific transcription-initiation factor; Region: Rrn6; pfam10214 637382008499 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 637382008500 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 637382008501 AAA domain; Region: AAA_33; pfam13671 637382008502 ATP-binding site [chemical binding]; other site 637382008503 Gluconate-6-phosphate binding site [chemical binding]; other site 637382008504 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 637382008505 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 637382008506 NADP binding site [chemical binding]; other site 637382008507 homodimer interface [polypeptide binding]; other site 637382008508 active site 637382008509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 637382008510 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 637382008511 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 637382008512 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382008513 DNA binding site [nucleotide binding] 637382008514 domain linker motif; other site 637382008515 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 637382008516 putative ligand binding site [chemical binding]; other site 637382008517 putative dimerization interface [polypeptide binding]; other site 637382008518 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 637382008519 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 637382008520 putative ligand binding site [chemical binding]; other site 637382008521 NAD binding site [chemical binding]; other site 637382008522 catalytic site [active] 637382008523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382008524 D-galactonate transporter; Region: 2A0114; TIGR00893 637382008525 putative substrate translocation pore; other site 637382008526 Uncharacterized conserved protein [Function unknown]; Region: COG4702 637382008527 phosphogluconate dehydratase; Validated; Region: PRK09054 637382008528 6-phosphogluconate dehydratase; Region: edd; TIGR01196 637382008529 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 637382008530 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 637382008531 chorismate binding enzyme; Region: Chorismate_bind; cl10555 637382008532 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 637382008533 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 637382008534 dimer interface [polypeptide binding]; other site 637382008535 tetramer interface [polypeptide binding]; other site 637382008536 PYR/PP interface [polypeptide binding]; other site 637382008537 TPP binding site [chemical binding]; other site 637382008538 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 637382008539 TPP-binding site; other site 637382008540 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 637382008541 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 637382008542 trimer interface [polypeptide binding]; other site 637382008543 oxyanion hole (OAH) forming residues; other site 637382008544 O-succinylbenzoate synthase; Provisional; Region: PRK05105 637382008545 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 637382008546 active site 637382008547 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 637382008548 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 637382008549 acyl-activating enzyme (AAE) consensus motif; other site 637382008550 putative AMP binding site [chemical binding]; other site 637382008551 putative active site [active] 637382008552 putative CoA binding site [chemical binding]; other site 637382008553 glycosyl transferase family protein; Provisional; Region: PRK08136 637382008554 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637382008555 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 637382008556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382008557 S-adenosylmethionine binding site [chemical binding]; other site 637382008558 transposase/IS protein; Provisional; Region: PRK09183 637382008559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382008560 Walker A motif; other site 637382008561 ATP binding site [chemical binding]; other site 637382008562 Walker B motif; other site 637382008563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382008564 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382008565 DNA-binding interface [nucleotide binding]; DNA binding site 637382008566 Integrase core domain; Region: rve; pfam00665 637382008567 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382008568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382008569 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 637382008570 putative effector binding pocket; other site 637382008571 putative dimerization interface [polypeptide binding]; other site 637382008572 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637382008573 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637382008574 active site 637382008575 catalytic tetrad [active] 637382008576 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637382008577 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637382008578 active site 637382008579 catalytic tetrad [active] 637382008580 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 637382008581 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 637382008582 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 637382008583 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 637382008584 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 637382008585 Predicted membrane protein [Function unknown]; Region: COG4984 637382008586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382008587 MULE transposase domain; Region: MULE; pfam10551 637382008588 Uncharacterized conserved protein [Function unknown]; Region: COG2850 637382008589 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 637382008590 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 637382008591 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637382008592 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637382008593 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 637382008594 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 637382008595 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 637382008596 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 637382008597 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 637382008598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382008599 MULE transposase domain; Region: MULE; pfam10551 637382008600 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 637382008601 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 637382008602 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 637382008603 nudix motif; other site 637382008604 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637382008605 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 637382008606 active site 637382008607 metal binding site [ion binding]; metal-binding site 637382008608 homotetramer interface [polypeptide binding]; other site 637382008609 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637382008610 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 637382008611 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 637382008612 putative NAD(P) binding site [chemical binding]; other site 637382008613 putative active site [active] 637382008614 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 637382008615 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637382008616 Walker A/P-loop; other site 637382008617 ATP binding site [chemical binding]; other site 637382008618 Q-loop/lid; other site 637382008619 ABC transporter signature motif; other site 637382008620 Walker B; other site 637382008621 D-loop; other site 637382008622 H-loop/switch region; other site 637382008623 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637382008624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382008625 dimer interface [polypeptide binding]; other site 637382008626 conserved gate region; other site 637382008627 putative PBP binding loops; other site 637382008628 ABC-ATPase subunit interface; other site 637382008629 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637382008630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382008631 dimer interface [polypeptide binding]; other site 637382008632 conserved gate region; other site 637382008633 putative PBP binding loops; other site 637382008634 ABC-ATPase subunit interface; other site 637382008635 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 637382008636 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382008637 substrate binding pocket [chemical binding]; other site 637382008638 membrane-bound complex binding site; other site 637382008639 hinge residues; other site 637382008640 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 637382008641 Flavoprotein; Region: Flavoprotein; pfam02441 637382008642 amidophosphoribosyltransferase; Provisional; Region: PRK09246 637382008643 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 637382008644 active site 637382008645 tetramer interface [polypeptide binding]; other site 637382008646 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637382008647 active site 637382008648 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 637382008649 colicin V production protein; Provisional; Region: PRK10845 637382008650 cell division protein DedD; Provisional; Region: PRK11633 637382008651 Sporulation related domain; Region: SPOR; pfam05036 637382008652 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 637382008653 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637382008654 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 637382008655 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 637382008656 hypothetical protein; Provisional; Region: PRK10847 637382008657 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637382008658 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 637382008659 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 637382008660 dimerization interface 3.5A [polypeptide binding]; other site 637382008661 active site 637382008662 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 637382008663 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 637382008664 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 637382008665 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 637382008666 ligand binding site [chemical binding]; other site 637382008667 NAD binding site [chemical binding]; other site 637382008668 catalytic site [active] 637382008669 homodimer interface [polypeptide binding]; other site 637382008670 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 637382008671 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382008672 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 637382008673 EamA-like transporter family; Region: EamA; pfam00892 637382008674 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 637382008675 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637382008676 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 637382008677 aspartate racemase; Region: asp_race; TIGR00035 637382008678 potential frameshift: common BLAST hit: gi|294504657|ref|YP_003568719.1| 3-oxoacyl-(acyl carrier protein) synthase 637382008679 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637382008680 active site 637382008681 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 637382008682 Uncharacterized conserved protein [Function unknown]; Region: COG4121 637382008683 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 637382008684 hydroxyglutarate oxidase; Provisional; Region: PRK11728 637382008685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 637382008686 hypothetical protein; Provisional; Region: PRK10621 637382008687 Predicted permeases [General function prediction only]; Region: COG0730 637382008688 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 637382008689 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 637382008690 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 637382008691 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 637382008692 Tetramer interface [polypeptide binding]; other site 637382008693 active site 637382008694 FMN-binding site [chemical binding]; other site 637382008695 HemK family putative methylases; Region: hemK_fam; TIGR00536 637382008696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382008697 S-adenosylmethionine binding site [chemical binding]; other site 637382008698 hypothetical protein; Provisional; Region: PRK04946 637382008699 Smr domain; Region: Smr; pfam01713 637382008700 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637382008701 catalytic core [active] 637382008702 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 637382008703 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 637382008704 substrate binding site [chemical binding]; other site 637382008705 oxyanion hole (OAH) forming residues; other site 637382008706 trimer interface [polypeptide binding]; other site 637382008707 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 637382008708 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 637382008709 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 637382008710 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 637382008711 dimer interface [polypeptide binding]; other site 637382008712 active site 637382008713 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 637382008714 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 637382008715 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 637382008716 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 637382008717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637382008718 binding surface 637382008719 TPR motif; other site 637382008720 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 637382008721 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 637382008722 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 637382008723 catalytic residues [active] 637382008724 central insert; other site 637382008725 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 637382008726 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 637382008727 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 637382008728 heme exporter protein CcmC; Region: ccmC; TIGR01191 637382008729 heme exporter protein CcmB; Region: ccmB; TIGR01190 637382008730 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 637382008731 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 637382008732 Walker A/P-loop; other site 637382008733 ATP binding site [chemical binding]; other site 637382008734 Q-loop/lid; other site 637382008735 ABC transporter signature motif; other site 637382008736 Walker B; other site 637382008737 D-loop; other site 637382008738 H-loop/switch region; other site 637382008739 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 637382008740 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 637382008741 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 637382008742 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 637382008743 PhnA protein; Region: PhnA; pfam03831 637382008744 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 637382008745 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 637382008746 ImpE protein; Region: ImpE; pfam07024 637382008747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 637382008748 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637382008749 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 637382008750 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 637382008751 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 637382008752 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 637382008753 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 637382008754 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637382008755 ligand binding site [chemical binding]; other site 637382008756 transposase/IS protein; Provisional; Region: PRK09183 637382008757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382008758 Walker A motif; other site 637382008759 ATP binding site [chemical binding]; other site 637382008760 Walker B motif; other site 637382008761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382008762 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382008763 DNA-binding interface [nucleotide binding]; DNA binding site 637382008764 Integrase core domain; Region: rve; pfam00665 637382008765 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 637382008766 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 637382008767 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 637382008768 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 637382008769 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 637382008770 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 637382008771 Protein of unknown function (DUF877); Region: DUF877; pfam05943 637382008772 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 637382008773 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637382008774 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637382008775 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382008776 PapC C-terminal domain; Region: PapC_C; pfam13953 637382008777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382008778 MULE transposase domain; Region: MULE; pfam10551 637382008779 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637382008780 PapC N-terminal domain; Region: PapC_N; pfam13954 637382008781 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382008782 putative chaperone protein EcpD; Provisional; Region: PRK09926 637382008783 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382008784 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637382008785 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637382008786 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 637382008787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382008788 Walker A motif; other site 637382008789 ATP binding site [chemical binding]; other site 637382008790 Walker B motif; other site 637382008791 arginine finger; other site 637382008792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382008793 Walker A motif; other site 637382008794 ATP binding site [chemical binding]; other site 637382008795 Walker B motif; other site 637382008796 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637382008797 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 637382008798 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 637382008799 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 637382008800 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 637382008801 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 637382008802 Fimbrial protein; Region: Fimbrial; pfam00419 637382008803 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 637382008804 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 637382008805 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637382008806 ligand binding site [chemical binding]; other site 637382008807 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 637382008808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637382008809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382008810 DNA binding residues [nucleotide binding] 637382008811 dimerization interface [polypeptide binding]; other site 637382008812 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 637382008813 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637382008814 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637382008815 catalytic residue [active] 637382008816 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 637382008817 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 637382008818 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 637382008819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382008820 dimer interface [polypeptide binding]; other site 637382008821 conserved gate region; other site 637382008822 putative PBP binding loops; other site 637382008823 ABC-ATPase subunit interface; other site 637382008824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382008825 dimer interface [polypeptide binding]; other site 637382008826 conserved gate region; other site 637382008827 putative PBP binding loops; other site 637382008828 ABC-ATPase subunit interface; other site 637382008829 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 637382008830 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 637382008831 Walker A/P-loop; other site 637382008832 ATP binding site [chemical binding]; other site 637382008833 Q-loop/lid; other site 637382008834 ABC transporter signature motif; other site 637382008835 Walker B; other site 637382008836 D-loop; other site 637382008837 H-loop/switch region; other site 637382008838 Predicted membrane protein [Function unknown]; Region: COG4331 637382008839 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 637382008840 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 637382008841 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 637382008842 putative [Fe4-S4] binding site [ion binding]; other site 637382008843 putative molybdopterin cofactor binding site [chemical binding]; other site 637382008844 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 637382008845 putative molybdopterin cofactor binding site; other site 637382008846 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 637382008847 4Fe-4S binding domain; Region: Fer4; cl02805 637382008848 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 637382008849 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 637382008850 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 637382008851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 637382008852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 637382008853 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 637382008854 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 637382008855 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 637382008856 aminotransferase; Validated; Region: PRK08175 637382008857 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637382008858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382008859 homodimer interface [polypeptide binding]; other site 637382008860 catalytic residue [active] 637382008861 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 637382008862 glucokinase, proteobacterial type; Region: glk; TIGR00749 637382008863 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637382008864 nucleotide binding site [chemical binding]; other site 637382008865 Predicted membrane protein [Function unknown]; Region: COG4125 637382008866 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 637382008867 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 637382008868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382008869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382008870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637382008871 dimerization interface [polypeptide binding]; other site 637382008872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637382008873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637382008874 active site 637382008875 catalytic tetrad [active] 637382008876 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 637382008877 manganese transport protein MntH; Reviewed; Region: PRK00701 637382008878 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 637382008879 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 637382008880 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 637382008881 Nucleoside recognition; Region: Gate; pfam07670 637382008882 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 637382008883 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 637382008884 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 637382008885 HIGH motif; other site 637382008886 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 637382008887 active site 637382008888 KMSKS motif; other site 637382008889 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382008890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 637382008891 FlxA-like protein; Region: FlxA; pfam14282 637382008892 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 637382008893 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 637382008894 nucleotide binding pocket [chemical binding]; other site 637382008895 K-X-D-G motif; other site 637382008896 catalytic site [active] 637382008897 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 637382008898 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 637382008899 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 637382008900 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 637382008901 Dimer interface [polypeptide binding]; other site 637382008902 BRCT sequence motif; other site 637382008903 cell division protein ZipA; Provisional; Region: PRK03427 637382008904 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 637382008905 FtsZ protein binding site [polypeptide binding]; other site 637382008906 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 637382008907 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 637382008908 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 637382008909 dimer interface [polypeptide binding]; other site 637382008910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382008911 catalytic residue [active] 637382008912 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 637382008913 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 637382008914 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 637382008915 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 637382008916 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 637382008917 HPr interaction site; other site 637382008918 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637382008919 active site 637382008920 phosphorylation site [posttranslational modification] 637382008921 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382008922 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382008923 dimerization interface [polypeptide binding]; other site 637382008924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382008925 dimer interface [polypeptide binding]; other site 637382008926 phosphorylation site [posttranslational modification] 637382008927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382008928 ATP binding site [chemical binding]; other site 637382008929 Mg2+ binding site [ion binding]; other site 637382008930 G-X-G motif; other site 637382008931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637382008932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382008933 active site 637382008934 phosphorylation site [posttranslational modification] 637382008935 intermolecular recognition site; other site 637382008936 dimerization interface [polypeptide binding]; other site 637382008937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382008938 DNA binding site [nucleotide binding] 637382008939 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 637382008940 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382008941 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382008942 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 637382008943 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637382008944 Walker A/P-loop; other site 637382008945 ATP binding site [chemical binding]; other site 637382008946 Q-loop/lid; other site 637382008947 ABC transporter signature motif; other site 637382008948 Walker B; other site 637382008949 D-loop; other site 637382008950 H-loop/switch region; other site 637382008951 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637382008952 FtsX-like permease family; Region: FtsX; pfam02687 637382008953 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 637382008954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637382008955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637382008956 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637382008957 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 637382008958 active site residue [active] 637382008959 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 637382008960 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 637382008961 Na binding site [ion binding]; other site 637382008962 peptidase; Provisional; Region: PRK15173 637382008963 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 637382008964 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 637382008965 active site 637382008966 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 637382008967 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637382008968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382008969 homodimer interface [polypeptide binding]; other site 637382008970 catalytic residue [active] 637382008971 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 637382008972 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 637382008973 metal ion-dependent adhesion site (MIDAS); other site 637382008974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637382008975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382008976 dimer interface [polypeptide binding]; other site 637382008977 phosphorylation site [posttranslational modification] 637382008978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382008979 ATP binding site [chemical binding]; other site 637382008980 Mg2+ binding site [ion binding]; other site 637382008981 G-X-G motif; other site 637382008982 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637382008983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382008984 active site 637382008985 phosphorylation site [posttranslational modification] 637382008986 intermolecular recognition site; other site 637382008987 dimerization interface [polypeptide binding]; other site 637382008988 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382008989 DNA binding site [nucleotide binding] 637382008990 type III secretion protein GogB; Provisional; Region: PRK15386 637382008991 cysteine synthase B; Region: cysM; TIGR01138 637382008992 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 637382008993 dimer interface [polypeptide binding]; other site 637382008994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382008995 catalytic residue [active] 637382008996 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 637382008997 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 637382008998 Walker A/P-loop; other site 637382008999 ATP binding site [chemical binding]; other site 637382009000 Q-loop/lid; other site 637382009001 ABC transporter signature motif; other site 637382009002 Walker B; other site 637382009003 D-loop; other site 637382009004 H-loop/switch region; other site 637382009005 TOBE-like domain; Region: TOBE_3; pfam12857 637382009006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382009007 dimer interface [polypeptide binding]; other site 637382009008 conserved gate region; other site 637382009009 putative PBP binding loops; other site 637382009010 ABC-ATPase subunit interface; other site 637382009011 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 637382009012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382009013 dimer interface [polypeptide binding]; other site 637382009014 conserved gate region; other site 637382009015 putative PBP binding loops; other site 637382009016 ABC-ATPase subunit interface; other site 637382009017 thiosulfate transporter subunit; Provisional; Region: PRK10852 637382009018 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 637382009019 putative sialic acid transporter; Provisional; Region: PRK03893 637382009020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382009021 putative substrate translocation pore; other site 637382009022 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637382009023 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637382009024 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637382009025 putative active site [active] 637382009026 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 637382009027 N-acetylmannosamine kinase; Provisional; Region: PRK05082 637382009028 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637382009029 nucleotide binding site [chemical binding]; other site 637382009030 potential frameshift: common BLAST hit: gi|162418777|ref|YP_001607164.1| leucine rich repeat domain-containing protein 637382009031 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 637382009032 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 637382009033 Leucine rich repeat; Region: LRR_8; pfam13855 637382009034 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 637382009035 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 637382009036 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 637382009037 putative active site cavity [active] 637382009038 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 637382009039 Class I aldolases; Region: Aldolase_Class_I; cl17187 637382009040 catalytic residue [active] 637382009041 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 637382009042 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 637382009043 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 637382009044 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 637382009045 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 637382009046 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637382009047 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637382009048 putative acetyltransferase; Provisional; Region: PRK03624 637382009049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637382009050 Coenzyme A binding pocket [chemical binding]; other site 637382009051 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 637382009052 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 637382009053 hypothetical protein; Validated; Region: PRK00124 637382009054 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 637382009055 Malic enzyme, N-terminal domain; Region: malic; pfam00390 637382009056 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 637382009057 putative NAD(P) binding site [chemical binding]; other site 637382009058 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 637382009059 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 637382009060 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 637382009061 dimer interface [polypeptide binding]; other site 637382009062 ADP-ribose binding site [chemical binding]; other site 637382009063 active site 637382009064 nudix motif; other site 637382009065 metal binding site [ion binding]; metal-binding site 637382009066 cytochrome c-type protein NapC; Provisional; Region: PRK10617 637382009067 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 637382009068 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 637382009069 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 637382009070 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 637382009071 [4Fe-4S] binding site [ion binding]; other site 637382009072 molybdopterin cofactor binding site; other site 637382009073 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 637382009074 molybdopterin cofactor binding site; other site 637382009075 ferredoxin-type protein; Provisional; Region: PRK10194 637382009076 transcriptional regulator NarP; Provisional; Region: PRK10403 637382009077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382009078 active site 637382009079 phosphorylation site [posttranslational modification] 637382009080 intermolecular recognition site; other site 637382009081 dimerization interface [polypeptide binding]; other site 637382009082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382009083 DNA binding residues [nucleotide binding] 637382009084 dimerization interface [polypeptide binding]; other site 637382009085 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 637382009086 Protein export membrane protein; Region: SecD_SecF; cl14618 637382009087 Protein export membrane protein; Region: SecD_SecF; cl14618 637382009088 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 637382009089 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 637382009090 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382009091 FeS/SAM binding site; other site 637382009092 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 637382009093 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 637382009094 Sulfatase; Region: Sulfatase; pfam00884 637382009095 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 637382009096 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 637382009097 Walker A/P-loop; other site 637382009098 ATP binding site [chemical binding]; other site 637382009099 Q-loop/lid; other site 637382009100 ABC transporter signature motif; other site 637382009101 Walker B; other site 637382009102 D-loop; other site 637382009103 H-loop/switch region; other site 637382009104 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 637382009105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382009106 dimer interface [polypeptide binding]; other site 637382009107 conserved gate region; other site 637382009108 ABC-ATPase subunit interface; other site 637382009109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382009110 dimer interface [polypeptide binding]; other site 637382009111 conserved gate region; other site 637382009112 putative PBP binding loops; other site 637382009113 ABC-ATPase subunit interface; other site 637382009114 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 637382009115 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 637382009116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637382009117 TPR motif; other site 637382009118 Tetratrico peptide repeat; Region: TPR_5; pfam12688 637382009119 binding surface 637382009120 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 637382009121 ArsC family; Region: ArsC; pfam03960 637382009122 putative catalytic residues [active] 637382009123 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 637382009124 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 637382009125 metal binding site [ion binding]; metal-binding site 637382009126 dimer interface [polypeptide binding]; other site 637382009127 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 637382009128 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 637382009129 potential frameshift: common BLAST hit: gi|294504802|ref|YP_003568864.1| putative acetyltransferase 637382009130 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 637382009131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637382009132 Coenzyme A binding pocket [chemical binding]; other site 637382009133 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 637382009134 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 637382009135 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 637382009136 Helicase; Region: Helicase_RecD; pfam05127 637382009137 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 637382009138 Predicted membrane protein [Function unknown]; Region: COG2707 637382009139 Predicted metalloprotease [General function prediction only]; Region: COG2321 637382009140 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 637382009141 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 637382009142 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 637382009143 ATP binding site [chemical binding]; other site 637382009144 active site 637382009145 substrate binding site [chemical binding]; other site 637382009146 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382009147 lipoprotein; Provisional; Region: PRK11679 637382009148 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 637382009149 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 637382009150 dihydrodipicolinate synthase; Region: dapA; TIGR00674 637382009151 dimer interface [polypeptide binding]; other site 637382009152 active site 637382009153 catalytic residue [active] 637382009154 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 637382009155 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 637382009156 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 637382009157 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 637382009158 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 637382009159 catalytic triad [active] 637382009160 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637382009161 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637382009162 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 637382009163 Peptidase family M48; Region: Peptidase_M48; pfam01435 637382009164 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 637382009165 ArsC family; Region: ArsC; pfam03960 637382009166 catalytic residues [active] 637382009167 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 637382009168 DNA replication initiation factor; Provisional; Region: PRK08084 637382009169 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382009170 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 637382009171 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 637382009172 active site 637382009173 HIGH motif; other site 637382009174 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 637382009175 KMSKS motif; other site 637382009176 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 637382009177 tRNA binding surface [nucleotide binding]; other site 637382009178 anticodon binding site; other site 637382009179 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 637382009180 substrate binding site [chemical binding]; other site 637382009181 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 637382009182 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637382009183 putative active site [active] 637382009184 putative metal binding site [ion binding]; other site 637382009185 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 637382009186 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 637382009187 ATP-grasp domain; Region: ATP-grasp; pfam02222 637382009188 potential frameshift: common BLAST hit: gi|294504822|ref|YP_003568884.1| putative permease 637382009189 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 637382009190 FtsX-like permease family; Region: FtsX; pfam02687 637382009191 FtsX-like permease family; Region: FtsX; pfam02687 637382009192 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637382009193 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 637382009194 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637382009195 Walker A/P-loop; other site 637382009196 ATP binding site [chemical binding]; other site 637382009197 Q-loop/lid; other site 637382009198 ABC transporter signature motif; other site 637382009199 Walker B; other site 637382009200 D-loop; other site 637382009201 H-loop/switch region; other site 637382009202 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 637382009203 active site 637382009204 catalytic triad [active] 637382009205 oxyanion hole [active] 637382009206 switch loop; other site 637382009207 oxidoreductase; Provisional; Region: PRK08017 637382009208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637382009209 NAD(P) binding site [chemical binding]; other site 637382009210 active site 637382009211 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 637382009212 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 637382009213 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 637382009214 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 637382009215 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 637382009216 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 637382009217 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 637382009218 DNA binding residues [nucleotide binding] 637382009219 dimer interface [polypeptide binding]; other site 637382009220 copper binding site [ion binding]; other site 637382009221 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637382009222 metal-binding site [ion binding] 637382009223 copper exporting ATPase; Provisional; Region: copA; PRK10671 637382009224 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637382009225 metal-binding site [ion binding] 637382009226 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637382009227 metal-binding site [ion binding] 637382009228 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637382009229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382009230 motif II; other site 637382009231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 637382009232 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 637382009233 putative deacylase active site [active] 637382009234 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637382009235 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 637382009236 active site 637382009237 metal binding site [ion binding]; metal-binding site 637382009238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382009239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637382009240 putative substrate translocation pore; other site 637382009241 putative cation:proton antiport protein; Provisional; Region: PRK10669 637382009242 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 637382009243 TrkA-N domain; Region: TrkA_N; pfam02254 637382009244 inosine/guanosine kinase; Provisional; Region: PRK15074 637382009245 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637382009246 substrate binding site [chemical binding]; other site 637382009247 ATP binding site [chemical binding]; other site 637382009248 LPS O-antigen length regulator; Provisional; Region: PRK10381 637382009249 Chain length determinant protein; Region: Wzz; cl15801 637382009250 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 637382009251 phosphomannomutase CpsG; Provisional; Region: PRK15414 637382009252 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 637382009253 active site 637382009254 substrate binding site [chemical binding]; other site 637382009255 metal binding site [ion binding]; metal-binding site 637382009256 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 637382009257 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 637382009258 metal-binding site 637382009259 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 637382009260 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 637382009261 Substrate binding site; other site 637382009262 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 637382009263 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 637382009264 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 637382009265 NADP binding site [chemical binding]; other site 637382009266 active site 637382009267 putative substrate binding site [chemical binding]; other site 637382009268 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 637382009269 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 637382009270 substrate binding site [chemical binding]; other site 637382009271 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 637382009272 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 637382009273 NADP-binding site; other site 637382009274 homotetramer interface [polypeptide binding]; other site 637382009275 homodimer interface [polypeptide binding]; other site 637382009276 active site 637382009277 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 637382009278 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 637382009279 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 637382009280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637382009281 active site 637382009282 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637382009283 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 637382009284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637382009285 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 637382009286 NAD(P) binding site [chemical binding]; other site 637382009287 active site 637382009288 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 637382009289 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 637382009290 inhibitor-cofactor binding pocket; inhibition site 637382009291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382009292 catalytic residue [active] 637382009293 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 637382009294 NAD binding site [chemical binding]; other site 637382009295 homotetramer interface [polypeptide binding]; other site 637382009296 homodimer interface [polypeptide binding]; other site 637382009297 substrate binding site [chemical binding]; other site 637382009298 active site 637382009299 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 637382009300 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 637382009301 substrate binding site; other site 637382009302 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 637382009303 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637382009304 catalytic loop [active] 637382009305 iron binding site [ion binding]; other site 637382009306 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 637382009307 FAD binding pocket [chemical binding]; other site 637382009308 FAD binding motif [chemical binding]; other site 637382009309 phosphate binding motif [ion binding]; other site 637382009310 beta-alpha-beta structure motif; other site 637382009311 NAD binding pocket [chemical binding]; other site 637382009312 ferrochelatase; Reviewed; Region: hemH; PRK00035 637382009313 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 637382009314 C-terminal domain interface [polypeptide binding]; other site 637382009315 active site 637382009316 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 637382009317 active site 637382009318 N-terminal domain interface [polypeptide binding]; other site 637382009319 adenylate kinase; Reviewed; Region: adk; PRK00279 637382009320 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 637382009321 AMP-binding site [chemical binding]; other site 637382009322 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 637382009323 heat shock protein 90; Provisional; Region: PRK05218 637382009324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382009325 ATP binding site [chemical binding]; other site 637382009326 Mg2+ binding site [ion binding]; other site 637382009327 G-X-G motif; other site 637382009328 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 637382009329 RecR protein; Region: RecR; pfam02132 637382009330 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 637382009331 putative active site [active] 637382009332 putative metal-binding site [ion binding]; other site 637382009333 tetramer interface [polypeptide binding]; other site 637382009334 hypothetical protein; Validated; Region: PRK00153 637382009335 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 637382009336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382009337 Walker A motif; other site 637382009338 ATP binding site [chemical binding]; other site 637382009339 Walker B motif; other site 637382009340 arginine finger; other site 637382009341 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 637382009342 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 637382009343 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 637382009344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637382009345 active site 637382009346 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 637382009347 hypothetical protein; Provisional; Region: PRK11281 637382009348 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 637382009349 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637382009350 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 637382009351 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 637382009352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637382009353 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 637382009354 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 637382009355 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382009356 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382009357 potential frameshift: common BLAST hit: gi|294504868|ref|YP_003568930.1| multidrug efflux protein 637382009358 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 637382009359 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 637382009360 Protein export membrane protein; Region: SecD_SecF; cl14618 637382009361 Hha toxicity attenuator; Provisional; Region: PRK10667 637382009362 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 637382009363 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637382009364 DNA binding site [nucleotide binding] 637382009365 active site 637382009366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 637382009367 acyl-CoA thioesterase II; Provisional; Region: PRK10526 637382009368 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 637382009369 active site 637382009370 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 637382009371 catalytic triad [active] 637382009372 dimer interface [polypeptide binding]; other site 637382009373 ammonium transporter; Provisional; Region: PRK10666 637382009374 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 637382009375 Nitrogen regulatory protein P-II; Region: P-II; smart00938 637382009376 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 637382009377 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637382009378 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 637382009379 Walker A/P-loop; other site 637382009380 ATP binding site [chemical binding]; other site 637382009381 Q-loop/lid; other site 637382009382 ABC transporter signature motif; other site 637382009383 Walker B; other site 637382009384 D-loop; other site 637382009385 H-loop/switch region; other site 637382009386 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 637382009387 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637382009388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382009389 Walker A/P-loop; other site 637382009390 ATP binding site [chemical binding]; other site 637382009391 Q-loop/lid; other site 637382009392 ABC transporter signature motif; other site 637382009393 Walker B; other site 637382009394 D-loop; other site 637382009395 H-loop/switch region; other site 637382009396 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 637382009397 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637382009398 putative DNA binding site [nucleotide binding]; other site 637382009399 putative Zn2+ binding site [ion binding]; other site 637382009400 AsnC family; Region: AsnC_trans_reg; pfam01037 637382009401 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 637382009402 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 637382009403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382009404 catalytic residue [active] 637382009405 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 637382009406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382009407 active site 637382009408 motif I; other site 637382009409 motif II; other site 637382009410 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 637382009411 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 637382009412 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 637382009413 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 637382009414 Ligand Binding Site [chemical binding]; other site 637382009415 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 637382009416 active site 637382009417 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 637382009418 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 637382009419 periplasmic folding chaperone; Provisional; Region: PRK10788 637382009420 SurA N-terminal domain; Region: SurA_N_3; cl07813 637382009421 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 637382009422 potential frameshift: common BLAST hit: gi|145600050|ref|YP_001164126.1| DNA-binding ATP-dependent protease La 637382009423 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 637382009424 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 637382009425 Found in ATP-dependent protease La (LON); Region: LON; smart00464 637382009426 Found in ATP-dependent protease La (LON); Region: LON; smart00464 637382009427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382009428 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637382009429 Walker A motif; other site 637382009430 ATP binding site [chemical binding]; other site 637382009431 Walker B motif; other site 637382009432 arginine finger; other site 637382009433 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 637382009434 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 637382009435 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 637382009436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382009437 Walker A motif; other site 637382009438 ATP binding site [chemical binding]; other site 637382009439 Walker B motif; other site 637382009440 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637382009441 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 637382009442 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 637382009443 oligomer interface [polypeptide binding]; other site 637382009444 active site residues [active] 637382009445 trigger factor; Provisional; Region: tig; PRK01490 637382009446 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 637382009447 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 637382009448 transcriptional regulator BolA; Provisional; Region: PRK11628 637382009449 hypothetical protein; Provisional; Region: PRK11627 637382009450 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 637382009451 muropeptide transporter; Reviewed; Region: ampG; PRK11902 637382009452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382009453 putative substrate translocation pore; other site 637382009454 hypothetical protein; Provisional; Region: PRK11528 637382009455 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 637382009456 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 637382009457 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 637382009458 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 637382009459 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 637382009460 D-pathway; other site 637382009461 Putative ubiquinol binding site [chemical binding]; other site 637382009462 Low-spin heme (heme b) binding site [chemical binding]; other site 637382009463 Putative water exit pathway; other site 637382009464 Binuclear center (heme o3/CuB) [ion binding]; other site 637382009465 K-pathway; other site 637382009466 Putative proton exit pathway; other site 637382009467 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 637382009468 Subunit III/IV interface [polypeptide binding]; other site 637382009469 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 637382009470 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 637382009471 UbiA prenyltransferase family; Region: UbiA; pfam01040 637382009472 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637382009473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382009474 putative substrate translocation pore; other site 637382009475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 637382009476 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 637382009477 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 637382009478 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 637382009479 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 637382009480 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 637382009481 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 637382009482 conserved cys residue [active] 637382009483 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 637382009484 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 637382009485 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 637382009486 Ligand Binding Site [chemical binding]; other site 637382009487 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637382009488 active site residue [active] 637382009489 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 637382009490 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 637382009491 substrate binding pocket [chemical binding]; other site 637382009492 chain length determination region; other site 637382009493 substrate-Mg2+ binding site; other site 637382009494 catalytic residues [active] 637382009495 aspartate-rich region 1; other site 637382009496 active site lid residues [active] 637382009497 aspartate-rich region 2; other site 637382009498 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 637382009499 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 637382009500 TPP-binding site; other site 637382009501 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637382009502 PYR/PP interface [polypeptide binding]; other site 637382009503 dimer interface [polypeptide binding]; other site 637382009504 TPP binding site [chemical binding]; other site 637382009505 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637382009506 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382009507 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 637382009508 tetramer interfaces [polypeptide binding]; other site 637382009509 binuclear metal-binding site [ion binding]; other site 637382009510 thiamine monophosphate kinase; Provisional; Region: PRK05731 637382009511 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 637382009512 ATP binding site [chemical binding]; other site 637382009513 dimerization interface [polypeptide binding]; other site 637382009514 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 637382009515 putative RNA binding site [nucleotide binding]; other site 637382009516 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 637382009517 homopentamer interface [polypeptide binding]; other site 637382009518 active site 637382009519 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 637382009520 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 637382009521 catalytic motif [active] 637382009522 Zn binding site [ion binding]; other site 637382009523 RibD C-terminal domain; Region: RibD_C; cl17279 637382009524 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 637382009525 ATP cone domain; Region: ATP-cone; pfam03477 637382009526 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 637382009527 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 637382009528 Protein export membrane protein; Region: SecD_SecF; pfam02355 637382009529 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 637382009530 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 637382009531 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 637382009532 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 637382009533 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 637382009534 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 637382009535 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 637382009536 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 637382009537 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 637382009538 Protein of unknown function, DUF479; Region: DUF479; cl01203 637382009539 peroxidase; Provisional; Region: PRK15000 637382009540 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 637382009541 dimer interface [polypeptide binding]; other site 637382009542 decamer (pentamer of dimers) interface [polypeptide binding]; other site 637382009543 catalytic triad [active] 637382009544 peroxidatic and resolving cysteines [active] 637382009545 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 637382009546 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 637382009547 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 637382009548 C factor cell-cell signaling protein; Provisional; Region: PRK09009 637382009549 NADP binding site [chemical binding]; other site 637382009550 homodimer interface [polypeptide binding]; other site 637382009551 active site 637382009552 maltodextrin glucosidase; Provisional; Region: PRK10785 637382009553 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 637382009554 homodimer interface [polypeptide binding]; other site 637382009555 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 637382009556 active site 637382009557 homodimer interface [polypeptide binding]; other site 637382009558 catalytic site [active] 637382009559 putative proline-specific permease; Provisional; Region: proY; PRK10580 637382009560 Spore germination protein; Region: Spore_permease; cl17796 637382009561 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 637382009562 PBP superfamily domain; Region: PBP_like_2; cl17296 637382009563 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 637382009564 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 637382009565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637382009566 putative active site [active] 637382009567 heme pocket [chemical binding]; other site 637382009568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382009569 dimer interface [polypeptide binding]; other site 637382009570 phosphorylation site [posttranslational modification] 637382009571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382009572 ATP binding site [chemical binding]; other site 637382009573 Mg2+ binding site [ion binding]; other site 637382009574 G-X-G motif; other site 637382009575 transcriptional regulator PhoB; Provisional; Region: PRK10161 637382009576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382009577 active site 637382009578 phosphorylation site [posttranslational modification] 637382009579 intermolecular recognition site; other site 637382009580 dimerization interface [polypeptide binding]; other site 637382009581 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382009582 DNA binding site [nucleotide binding] 637382009583 exonuclease subunit SbcD; Provisional; Region: PRK10966 637382009584 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 637382009585 active site 637382009586 metal binding site [ion binding]; metal-binding site 637382009587 DNA binding site [nucleotide binding] 637382009588 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 637382009589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382009590 AAA domain; Region: AAA_23; pfam13476 637382009591 Walker A/P-loop; other site 637382009592 ATP binding site [chemical binding]; other site 637382009593 Q-loop/lid; other site 637382009594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382009595 ABC transporter signature motif; other site 637382009596 Walker B; other site 637382009597 D-loop; other site 637382009598 H-loop/switch region; other site 637382009599 fructokinase; Reviewed; Region: PRK09557 637382009600 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637382009601 nucleotide binding site [chemical binding]; other site 637382009602 recombination associated protein; Reviewed; Region: rdgC; PRK00321 637382009603 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 637382009604 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 637382009605 ADP binding site [chemical binding]; other site 637382009606 magnesium binding site [ion binding]; other site 637382009607 putative shikimate binding site; other site 637382009608 Phospholipid N-methyltransferase [Lipid metabolism]; Region: COG3963 637382009609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382009610 Flagellar regulator YcgR; Region: YcgR; pfam07317 637382009611 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 637382009612 PilZ domain; Region: PilZ; pfam07238 637382009613 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 637382009614 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 637382009615 putative catalytic cysteine [active] 637382009616 gamma-glutamyl kinase; Provisional; Region: PRK05429 637382009617 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 637382009618 nucleotide binding site [chemical binding]; other site 637382009619 homotetrameric interface [polypeptide binding]; other site 637382009620 putative phosphate binding site [ion binding]; other site 637382009621 putative allosteric binding site; other site 637382009622 PUA domain; Region: PUA; pfam01472 637382009623 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 637382009624 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 637382009625 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 637382009626 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637382009627 active site 637382009628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 637382009629 Chitin binding domain; Region: Chitin_bind_3; pfam03067 637382009630 PKD domain; Region: PKD; pfam00801 637382009631 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382009632 LysR substrate binding domain; Region: LysR_substrate; pfam03466 637382009633 dimerization interface [polypeptide binding]; other site 637382009634 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 637382009635 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 637382009636 metal binding site [ion binding]; metal-binding site 637382009637 dimer interface [polypeptide binding]; other site 637382009638 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 637382009639 active site 637382009640 DNA polymerase IV; Validated; Region: PRK02406 637382009641 DNA binding site [nucleotide binding] 637382009642 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 637382009643 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 637382009644 putative active site [active] 637382009645 catalytic site [active] 637382009646 putative metal binding site [ion binding]; other site 637382009647 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 637382009648 ApbE family; Region: ApbE; pfam02424 637382009649 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 637382009650 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637382009651 catalytic loop [active] 637382009652 iron binding site [ion binding]; other site 637382009653 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 637382009654 FAD binding pocket [chemical binding]; other site 637382009655 FAD binding motif [chemical binding]; other site 637382009656 phosphate binding motif [ion binding]; other site 637382009657 beta-alpha-beta structure motif; other site 637382009658 NAD binding pocket [chemical binding]; other site 637382009659 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 637382009660 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 637382009661 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 637382009662 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 637382009663 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 637382009664 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 637382009665 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637382009666 E3 interaction surface; other site 637382009667 lipoyl attachment site [posttranslational modification]; other site 637382009668 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 637382009669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 637382009670 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637382009671 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 637382009672 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 637382009673 putative active site [active] 637382009674 putative dimer interface [polypeptide binding]; other site 637382009675 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 637382009676 dimer interface [polypeptide binding]; other site 637382009677 active site 637382009678 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 637382009679 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 637382009680 active site 637382009681 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 637382009682 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 637382009683 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 637382009684 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 637382009685 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 637382009686 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 637382009687 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 637382009688 allantoate amidohydrolase; Reviewed; Region: PRK09290 637382009689 active site 637382009690 metal binding site [ion binding]; metal-binding site 637382009691 dimer interface [polypeptide binding]; other site 637382009692 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637382009693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382009694 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382009695 DNA-binding interface [nucleotide binding]; DNA binding site 637382009696 Integrase core domain; Region: rve; pfam00665 637382009697 transposase/IS protein; Provisional; Region: PRK09183 637382009698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382009699 Walker A motif; other site 637382009700 ATP binding site [chemical binding]; other site 637382009701 Walker B motif; other site 637382009702 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 637382009703 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382009704 catalytic residue [active] 637382009705 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637382009706 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637382009707 Walker A/P-loop; other site 637382009708 ATP binding site [chemical binding]; other site 637382009709 Q-loop/lid; other site 637382009710 ABC transporter signature motif; other site 637382009711 Walker B; other site 637382009712 D-loop; other site 637382009713 H-loop/switch region; other site 637382009714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382009715 dimer interface [polypeptide binding]; other site 637382009716 conserved gate region; other site 637382009717 putative PBP binding loops; other site 637382009718 ABC-ATPase subunit interface; other site 637382009719 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637382009720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382009721 dimer interface [polypeptide binding]; other site 637382009722 conserved gate region; other site 637382009723 putative PBP binding loops; other site 637382009724 ABC-ATPase subunit interface; other site 637382009725 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637382009726 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382009727 substrate binding pocket [chemical binding]; other site 637382009728 membrane-bound complex binding site; other site 637382009729 hinge residues; other site 637382009730 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637382009731 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637382009732 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637382009733 putative active site [active] 637382009734 amidase; Provisional; Region: PRK09201 637382009735 Amidase; Region: Amidase; cl11426 637382009736 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 637382009737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382009738 putative substrate translocation pore; other site 637382009739 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 637382009740 putative L-valine exporter; Provisional; Region: PRK10408 637382009741 transcriptional repressor MprA; Provisional; Region: PRK10870 637382009742 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637382009743 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 637382009744 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382009745 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382009746 potential frameshift: common BLAST hit: gi|294504982|ref|YP_003569044.1| multidrug resistance protein B 637382009747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382009748 putative substrate translocation pore; other site 637382009749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382009750 putative methyltransferase; Provisional; Region: PRK10864 637382009751 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 637382009752 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 637382009753 Uncharacterized conserved protein [Function unknown]; Region: COG3148 637382009754 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 637382009755 CoA binding domain; Region: CoA_binding_2; pfam13380 637382009756 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 637382009757 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 637382009758 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 637382009759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637382009760 Coenzyme A binding pocket [chemical binding]; other site 637382009761 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 637382009762 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 637382009763 domain interface [polypeptide binding]; other site 637382009764 putative active site [active] 637382009765 catalytic site [active] 637382009766 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 637382009767 domain interface [polypeptide binding]; other site 637382009768 putative active site [active] 637382009769 catalytic site [active] 637382009770 lipoprotein; Provisional; Region: PRK10759 637382009771 potential frameshift: common BLAST hit: gi|294504989|ref|YP_003569051.1| Clp ATPase 637382009772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382009773 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637382009774 Walker A motif; other site 637382009775 ATP binding site [chemical binding]; other site 637382009776 Walker B motif; other site 637382009777 arginine finger; other site 637382009778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382009779 Walker A motif; other site 637382009780 ATP binding site [chemical binding]; other site 637382009781 Walker B motif; other site 637382009782 arginine finger; other site 637382009783 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637382009784 Clp amino terminal domain; Region: Clp_N; pfam02861 637382009785 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 637382009786 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 637382009787 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 637382009788 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637382009789 RNA binding surface [nucleotide binding]; other site 637382009790 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637382009791 active site 637382009792 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 637382009793 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 637382009794 30S subunit binding site; other site 637382009795 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382009796 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 637382009797 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 637382009798 Prephenate dehydratase; Region: PDT; pfam00800 637382009799 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 637382009800 putative L-Phe binding site [chemical binding]; other site 637382009801 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 637382009802 Chorismate mutase type II; Region: CM_2; cl00693 637382009803 prephenate dehydrogenase; Validated; Region: PRK08507 637382009804 potential frameshift: common BLAST hit: gi|294505000|ref|YP_003569062.1| 3-deoxy-7-phosphoheptulonate synthase 637382009805 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 637382009806 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 637382009807 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 637382009808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382009809 active site 637382009810 phosphorylation site [posttranslational modification] 637382009811 intermolecular recognition site; other site 637382009812 dimerization interface [polypeptide binding]; other site 637382009813 LytTr DNA-binding domain; Region: LytTR; pfam04397 637382009814 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 637382009815 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 637382009816 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 637382009817 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382009818 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 637382009819 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 637382009820 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 637382009821 RimM N-terminal domain; Region: RimM; pfam01782 637382009822 PRC-barrel domain; Region: PRC; pfam05239 637382009823 signal recognition particle protein; Provisional; Region: PRK10867 637382009824 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 637382009825 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 637382009826 P loop; other site 637382009827 GTP binding site [chemical binding]; other site 637382009828 Signal peptide binding domain; Region: SRP_SPB; pfam02978 637382009829 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 637382009830 hypothetical protein; Provisional; Region: PRK11573 637382009831 Domain of unknown function DUF21; Region: DUF21; pfam01595 637382009832 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637382009833 Transporter associated domain; Region: CorC_HlyC; smart01091 637382009834 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382009835 S-ribosylhomocysteinase; Provisional; Region: PRK02260 637382009836 glutamate--cysteine ligase; Provisional; Region: PRK02107 637382009837 Predicted membrane protein [Function unknown]; Region: COG1238 637382009838 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 637382009839 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382009840 motif II; other site 637382009841 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 637382009842 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 637382009843 active site 637382009844 motif 2; other site 637382009845 motif 3; other site 637382009846 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 637382009847 DHHA1 domain; Region: DHHA1; pfam02272 637382009848 recombination regulator RecX; Reviewed; Region: recX; PRK00117 637382009849 recombinase A; Provisional; Region: recA; PRK09354 637382009850 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 637382009851 hexamer interface [polypeptide binding]; other site 637382009852 Walker A motif; other site 637382009853 ATP binding site [chemical binding]; other site 637382009854 Walker B motif; other site 637382009855 hypothetical protein; Validated; Region: PRK03661 637382009856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382009857 putative MFS family transporter protein; Provisional; Region: PRK03633 637382009858 putative substrate translocation pore; other site 637382009859 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 637382009860 MarR family; Region: MarR_2; cl17246 637382009861 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637382009862 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 637382009863 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 637382009864 hexamer (dimer of trimers) interface [polypeptide binding]; other site 637382009865 substrate binding site [chemical binding]; other site 637382009866 trimer interface [polypeptide binding]; other site 637382009867 Mn binding site [ion binding]; other site 637382009868 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 637382009869 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 637382009870 N- and C-terminal domain interface [polypeptide binding]; other site 637382009871 active site 637382009872 MgATP binding site [chemical binding]; other site 637382009873 catalytic site [active] 637382009874 metal binding site [ion binding]; metal-binding site 637382009875 putative homotetramer interface [polypeptide binding]; other site 637382009876 putative homodimer interface [polypeptide binding]; other site 637382009877 glycerol binding site [chemical binding]; other site 637382009878 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 637382009879 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637382009880 PYR/PP interface [polypeptide binding]; other site 637382009881 dimer interface [polypeptide binding]; other site 637382009882 TPP binding site [chemical binding]; other site 637382009883 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637382009884 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637382009885 TPP-binding site [chemical binding]; other site 637382009886 dimer interface [polypeptide binding]; other site 637382009887 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382009888 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382009889 TM-ABC transporter signature motif; other site 637382009890 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637382009891 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382009892 Walker A/P-loop; other site 637382009893 ATP binding site [chemical binding]; other site 637382009894 Q-loop/lid; other site 637382009895 ABC transporter signature motif; other site 637382009896 Walker B; other site 637382009897 D-loop; other site 637382009898 H-loop/switch region; other site 637382009899 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382009900 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618 637382009901 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 637382009902 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 637382009903 ligand binding site [chemical binding]; other site 637382009904 dimerization interface [polypeptide binding]; other site 637382009905 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 637382009906 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 637382009907 dimer interface [polypeptide binding]; other site 637382009908 active site 637382009909 heme binding site [chemical binding]; other site 637382009910 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 637382009911 Soluble cytochrome b562 [Energy production and conversion]; Region: CybC; COG3783 637382009912 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 637382009913 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 637382009914 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 637382009915 4Fe-4S binding domain; Region: Fer4; cl02805 637382009916 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 637382009917 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 637382009918 putative [Fe4-S4] binding site [ion binding]; other site 637382009919 putative molybdopterin cofactor binding site [chemical binding]; other site 637382009920 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 637382009921 putative molybdopterin cofactor binding site; other site 637382009922 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK13213 637382009923 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 637382009924 intersubunit interface [polypeptide binding]; other site 637382009925 active site 637382009926 Zn2+ binding site [ion binding]; other site 637382009927 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637382009928 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 637382009929 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637382009930 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 637382009931 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 637382009932 ligand binding site [chemical binding]; other site 637382009933 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637382009934 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382009935 Walker A/P-loop; other site 637382009936 ATP binding site [chemical binding]; other site 637382009937 Q-loop/lid; other site 637382009938 ABC transporter signature motif; other site 637382009939 Walker B; other site 637382009940 D-loop; other site 637382009941 H-loop/switch region; other site 637382009942 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382009943 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382009944 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382009945 TM-ABC transporter signature motif; other site 637382009946 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382009947 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382009948 TM-ABC transporter signature motif; other site 637382009949 Putative L-xylulose-5-phosphate 3-epimerase [Carbohydrate transport and metabolism]; Region: SgaU; COG3623 637382009950 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 637382009951 AP (apurinic/apyrimidinic) site pocket; other site 637382009952 DNA interaction; other site 637382009953 Metal-binding active site; metal-binding site 637382009954 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 637382009955 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 637382009956 putative N- and C-terminal domain interface [polypeptide binding]; other site 637382009957 putative active site [active] 637382009958 MgATP binding site [chemical binding]; other site 637382009959 catalytic site [active] 637382009960 metal binding site [ion binding]; metal-binding site 637382009961 putative xylulose binding site [chemical binding]; other site 637382009962 fumarate hydratase; Provisional; Region: PRK15389 637382009963 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 637382009964 Fumarase C-terminus; Region: Fumerase_C; pfam05683 637382009965 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 637382009966 active site 637382009967 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 637382009968 potential frameshift: common BLAST hit: gi|229220786|ref|NP_991743.2| outer membrane receptor 637382009969 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 637382009970 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637382009971 N-terminal plug; other site 637382009972 ligand-binding site [chemical binding]; other site 637382009973 cytochrome C peroxidase 637382009974 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637382009975 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382009976 substrate binding pocket [chemical binding]; other site 637382009977 membrane-bound complex binding site; other site 637382009978 hinge residues; other site 637382009979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637382009980 dimerization interface [polypeptide binding]; other site 637382009981 putative DNA binding site [nucleotide binding]; other site 637382009982 putative Zn2+ binding site [ion binding]; other site 637382009983 arsenical pump membrane protein; Provisional; Region: PRK15445 637382009984 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 637382009985 transmembrane helices; other site 637382009986 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 637382009987 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382009988 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637382009989 DAK2 domain; Region: Dak2; pfam02734 637382009990 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 637382009991 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 637382009992 short chain dehydrogenase; Provisional; Region: PRK06841 637382009993 classical (c) SDRs; Region: SDR_c; cd05233 637382009994 NAD(P) binding site [chemical binding]; other site 637382009995 active site 637382009996 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637382009997 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 637382009998 putative NAD(P) binding site [chemical binding]; other site 637382009999 catalytic Zn binding site [ion binding]; other site 637382010000 structural Zn binding site [ion binding]; other site 637382010001 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 637382010002 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 637382010003 MutS domain I; Region: MutS_I; pfam01624 637382010004 MutS domain II; Region: MutS_II; pfam05188 637382010005 MutS domain III; Region: MutS_III; pfam05192 637382010006 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 637382010007 Walker A/P-loop; other site 637382010008 ATP binding site [chemical binding]; other site 637382010009 Q-loop/lid; other site 637382010010 ABC transporter signature motif; other site 637382010011 Walker B; other site 637382010012 D-loop; other site 637382010013 H-loop/switch region; other site 637382010014 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 637382010015 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 637382010016 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637382010017 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637382010018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637382010019 DNA binding residues [nucleotide binding] 637382010020 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 637382010021 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637382010022 Peptidase family M23; Region: Peptidase_M23; pfam01551 637382010023 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 637382010024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382010025 S-adenosylmethionine binding site [chemical binding]; other site 637382010026 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 637382010027 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 637382010028 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 637382010029 Permutation of conserved domain; other site 637382010030 active site 637382010031 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 637382010032 homotrimer interaction site [polypeptide binding]; other site 637382010033 zinc binding site [ion binding]; other site 637382010034 CDP-binding sites; other site 637382010035 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 637382010036 substrate binding site; other site 637382010037 dimer interface; other site 637382010038 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 637382010039 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 637382010040 hypothetical protein; Provisional; Region: PRK10726 637382010041 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 637382010042 ligand-binding site [chemical binding]; other site 637382010043 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 637382010044 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 637382010045 CysD dimerization site [polypeptide binding]; other site 637382010046 G1 box; other site 637382010047 putative GEF interaction site [polypeptide binding]; other site 637382010048 GTP/Mg2+ binding site [chemical binding]; other site 637382010049 Switch I region; other site 637382010050 G2 box; other site 637382010051 G3 box; other site 637382010052 Switch II region; other site 637382010053 G4 box; other site 637382010054 G5 box; other site 637382010055 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 637382010056 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 637382010057 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 637382010058 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 637382010059 Active Sites [active] 637382010060 siroheme synthase; Provisional; Region: cysG; PRK10637 637382010061 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 637382010062 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 637382010063 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 637382010064 active site 637382010065 SAM binding site [chemical binding]; other site 637382010066 homodimer interface [polypeptide binding]; other site 637382010067 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 637382010068 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 637382010069 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 637382010070 sulfite reductase subunit beta; Provisional; Region: PRK13504 637382010071 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 637382010072 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 637382010073 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 637382010074 Flavodoxin; Region: Flavodoxin_1; pfam00258 637382010075 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 637382010076 FAD binding pocket [chemical binding]; other site 637382010077 FAD binding motif [chemical binding]; other site 637382010078 catalytic residues [active] 637382010079 NAD binding pocket [chemical binding]; other site 637382010080 phosphate binding motif [ion binding]; other site 637382010081 beta-alpha-beta structure motif; other site 637382010082 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 637382010083 active site 637382010084 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 637382010085 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 637382010086 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 637382010087 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 637382010088 E-class dimer interface [polypeptide binding]; other site 637382010089 P-class dimer interface [polypeptide binding]; other site 637382010090 active site 637382010091 Cu2+ binding site [ion binding]; other site 637382010092 Zn2+ binding site [ion binding]; other site 637382010093 enolase; Provisional; Region: eno; PRK00077 637382010094 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 637382010095 dimer interface [polypeptide binding]; other site 637382010096 metal binding site [ion binding]; metal-binding site 637382010097 substrate binding pocket [chemical binding]; other site 637382010098 CTP synthetase; Validated; Region: pyrG; PRK05380 637382010099 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 637382010100 Catalytic site [active] 637382010101 active site 637382010102 UTP binding site [chemical binding]; other site 637382010103 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 637382010104 active site 637382010105 putative oxyanion hole; other site 637382010106 catalytic triad [active] 637382010107 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 637382010108 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 637382010109 homodimer interface [polypeptide binding]; other site 637382010110 metal binding site [ion binding]; metal-binding site 637382010111 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 637382010112 homodimer interface [polypeptide binding]; other site 637382010113 active site 637382010114 putative chemical substrate binding site [chemical binding]; other site 637382010115 metal binding site [ion binding]; metal-binding site 637382010116 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 637382010117 HD domain; Region: HD_4; pfam13328 637382010118 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637382010119 synthetase active site [active] 637382010120 NTP binding site [chemical binding]; other site 637382010121 metal binding site [ion binding]; metal-binding site 637382010122 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 637382010123 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 637382010124 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 637382010125 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 637382010126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382010127 dimerization interface [polypeptide binding]; other site 637382010128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382010129 dimer interface [polypeptide binding]; other site 637382010130 phosphorylation site [posttranslational modification] 637382010131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382010132 ATP binding site [chemical binding]; other site 637382010133 Mg2+ binding site [ion binding]; other site 637382010134 G-X-G motif; other site 637382010135 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 637382010136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382010137 active site 637382010138 phosphorylation site [posttranslational modification] 637382010139 intermolecular recognition site; other site 637382010140 dimerization interface [polypeptide binding]; other site 637382010141 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637382010142 putative binding surface; other site 637382010143 active site 637382010144 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 637382010145 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637382010146 protein binding site [polypeptide binding]; other site 637382010147 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637382010148 serine endoprotease; Provisional; Region: PRK10942 637382010149 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 637382010150 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637382010151 Zn2+ binding site [ion binding]; other site 637382010152 Mg2+ binding site [ion binding]; other site 637382010153 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 637382010154 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 637382010155 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 637382010156 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 637382010157 cobalamin binding residues [chemical binding]; other site 637382010158 putative BtuC binding residues; other site 637382010159 dimer interface [polypeptide binding]; other site 637382010160 hypothetical protein; Provisional; Region: PRK10578 637382010161 UPF0126 domain; Region: UPF0126; pfam03458 637382010162 UPF0126 domain; Region: UPF0126; pfam03458 637382010163 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 637382010164 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 637382010165 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 637382010166 Cl- selectivity filter; other site 637382010167 Cl- binding residues [ion binding]; other site 637382010168 pore gating glutamate residue; other site 637382010169 dimer interface [polypeptide binding]; other site 637382010170 H+/Cl- coupling transport residue; other site 637382010171 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 637382010172 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637382010173 inhibitor-cofactor binding pocket; inhibition site 637382010174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382010175 catalytic residue [active] 637382010176 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637382010177 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382010178 ABC-ATPase subunit interface; other site 637382010179 dimer interface [polypeptide binding]; other site 637382010180 putative PBP binding regions; other site 637382010181 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382010182 ABC-ATPase subunit interface; other site 637382010183 dimer interface [polypeptide binding]; other site 637382010184 putative PBP binding regions; other site 637382010185 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 637382010186 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 637382010187 siderophore binding site; other site 637382010188 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 637382010189 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637382010190 Walker A/P-loop; other site 637382010191 ATP binding site [chemical binding]; other site 637382010192 Q-loop/lid; other site 637382010193 ABC transporter signature motif; other site 637382010194 Walker B; other site 637382010195 D-loop; other site 637382010196 H-loop/switch region; other site 637382010197 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 637382010198 Transglycosylase; Region: Transgly; pfam00912 637382010199 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 637382010200 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 637382010201 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637382010202 ATP binding site [chemical binding]; other site 637382010203 putative Mg++ binding site [ion binding]; other site 637382010204 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382010205 nucleotide binding region [chemical binding]; other site 637382010206 ATP-binding site [chemical binding]; other site 637382010207 Helicase associated domain (HA2); Region: HA2; pfam04408 637382010208 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 637382010209 2'-5' RNA ligase; Provisional; Region: PRK15124 637382010210 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 637382010211 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 637382010212 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 637382010213 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 637382010214 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 637382010215 active site 637382010216 nucleotide binding site [chemical binding]; other site 637382010217 HIGH motif; other site 637382010218 KMSKS motif; other site 637382010219 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 637382010220 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 637382010221 active site 637382010222 NTP binding site [chemical binding]; other site 637382010223 metal binding triad [ion binding]; metal-binding site 637382010224 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 637382010225 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 637382010226 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 637382010227 catalytic center binding site [active] 637382010228 ATP binding site [chemical binding]; other site 637382010229 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 637382010230 oligomerization interface [polypeptide binding]; other site 637382010231 active site 637382010232 metal binding site [ion binding]; metal-binding site 637382010233 pantoate--beta-alanine ligase; Region: panC; TIGR00018 637382010234 Pantoate-beta-alanine ligase; Region: PanC; cd00560 637382010235 active site 637382010236 ATP-binding site [chemical binding]; other site 637382010237 pantoate-binding site; other site 637382010238 HXXH motif; other site 637382010239 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 637382010240 tetramerization interface [polypeptide binding]; other site 637382010241 active site 637382010242 Bacterial SH3 domain; Region: SH3_3; cl17532 637382010243 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 637382010244 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 637382010245 putative active site [active] 637382010246 putative metal binding site [ion binding]; other site 637382010247 inner membrane transport permease; Provisional; Region: PRK15066 637382010248 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 637382010249 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637382010250 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637382010251 Walker A/P-loop; other site 637382010252 ATP binding site [chemical binding]; other site 637382010253 Q-loop/lid; other site 637382010254 ABC transporter signature motif; other site 637382010255 Walker B; other site 637382010256 D-loop; other site 637382010257 H-loop/switch region; other site 637382010258 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 637382010259 active site clefts [active] 637382010260 zinc binding site [ion binding]; other site 637382010261 dimer interface [polypeptide binding]; other site 637382010262 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637382010263 active site 637382010264 multicopper oxidase; Provisional; Region: PRK10965 637382010265 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 637382010266 Multicopper oxidase; Region: Cu-oxidase; pfam00394 637382010267 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 637382010268 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 637382010269 spermidine synthase; Provisional; Region: PRK00811 637382010270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382010271 S-adenosylmethionine binding site [chemical binding]; other site 637382010272 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 637382010273 aromatic amino acid exporter; Provisional; Region: PRK11689 637382010274 EamA-like transporter family; Region: EamA; cl17759 637382010275 hypothetical protein; Provisional; Region: PRK05248 637382010276 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 637382010277 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 637382010278 substrate binding site [chemical binding]; other site 637382010279 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 637382010280 substrate binding site [chemical binding]; other site 637382010281 ligand binding site [chemical binding]; other site 637382010282 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382010283 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 637382010284 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637382010285 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637382010286 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637382010287 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 637382010288 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637382010289 E3 interaction surface; other site 637382010290 lipoyl attachment site [posttranslational modification]; other site 637382010291 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637382010292 E3 interaction surface; other site 637382010293 lipoyl attachment site [posttranslational modification]; other site 637382010294 e3 binding domain; Region: E3_binding; pfam02817 637382010295 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 637382010296 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 637382010297 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 637382010298 dimer interface [polypeptide binding]; other site 637382010299 TPP-binding site [chemical binding]; other site 637382010300 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 637382010301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637382010302 DNA-binding site [nucleotide binding]; DNA binding site 637382010303 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 637382010304 aromatic amino acid transporter; Provisional; Region: PRK10238 637382010305 regulatory protein AmpE; Provisional; Region: PRK10987 637382010306 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 637382010307 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637382010308 amidase catalytic site [active] 637382010309 Zn binding residues [ion binding]; other site 637382010310 substrate binding site [chemical binding]; other site 637382010311 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 637382010312 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 637382010313 dimerization interface [polypeptide binding]; other site 637382010314 active site 637382010315 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 637382010316 putative major pilin subunit; Provisional; Region: PRK10574 637382010317 hypothetical protein; Provisional; Region: PRK10436 637382010318 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 637382010319 Walker A motif; other site 637382010320 ATP binding site [chemical binding]; other site 637382010321 Walker B motif; other site 637382010322 type IV pilin biogenesis protein; Provisional; Region: PRK10573 637382010323 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637382010324 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637382010325 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 637382010326 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 637382010327 active site 637382010328 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 637382010329 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 637382010330 CoA-binding site [chemical binding]; other site 637382010331 ATP-binding [chemical binding]; other site 637382010332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 637382010333 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382010334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382010335 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382010336 DNA-binding interface [nucleotide binding]; DNA binding site 637382010337 Integrase core domain; Region: rve; pfam00665 637382010338 transposase/IS protein; Provisional; Region: PRK09183 637382010339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382010340 Walker A motif; other site 637382010341 ATP binding site [chemical binding]; other site 637382010342 Walker B motif; other site 637382010343 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 637382010344 Mg2+ binding site [ion binding]; other site 637382010345 G-X-G motif; other site 637382010346 Uncharacterized conserved protein [Function unknown]; Region: COG1479 637382010347 Protein of unknown function DUF262; Region: DUF262; pfam03235 637382010348 Protein of unknown function DUF262; Region: DUF262; pfam03235 637382010349 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 637382010350 integrase; Provisional; Region: PRK09692 637382010351 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 637382010352 active site 637382010353 Int/Topo IB signature motif; other site 637382010354 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 637382010355 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 637382010356 potential frameshift: common BLAST hit: gi|186893894|ref|YP_001871006.1| YjgP/YjgQ family permease 637382010357 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 637382010358 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 637382010359 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 637382010360 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 637382010361 multifunctional aminopeptidase A; Provisional; Region: PRK00913 637382010362 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 637382010363 interface (dimer of trimers) [polypeptide binding]; other site 637382010364 Substrate-binding/catalytic site; other site 637382010365 Zn-binding sites [ion binding]; other site 637382010366 DNA polymerase III subunit chi; Validated; Region: PRK05728 637382010367 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 637382010368 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 637382010369 HIGH motif; other site 637382010370 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 637382010371 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 637382010372 active site 637382010373 KMSKS motif; other site 637382010374 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 637382010375 tRNA binding surface [nucleotide binding]; other site 637382010376 anticodon binding site; other site 637382010377 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 637382010378 RNase E inhibitor protein; Provisional; Region: PRK11191 637382010379 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 637382010380 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 637382010381 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637382010382 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 637382010383 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 637382010384 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 637382010385 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 637382010386 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 637382010387 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637382010388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382010389 dimer interface [polypeptide binding]; other site 637382010390 conserved gate region; other site 637382010391 putative PBP binding loops; other site 637382010392 ABC-ATPase subunit interface; other site 637382010393 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637382010394 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637382010395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382010396 dimer interface [polypeptide binding]; other site 637382010397 conserved gate region; other site 637382010398 ABC-ATPase subunit interface; other site 637382010399 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382010400 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 637382010401 Walker A/P-loop; other site 637382010402 ATP binding site [chemical binding]; other site 637382010403 Q-loop/lid; other site 637382010404 ABC transporter signature motif; other site 637382010405 Walker B; other site 637382010406 D-loop; other site 637382010407 H-loop/switch region; other site 637382010408 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 637382010409 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382010410 Walker A/P-loop; other site 637382010411 ATP binding site [chemical binding]; other site 637382010412 Q-loop/lid; other site 637382010413 ABC transporter signature motif; other site 637382010414 Walker B; other site 637382010415 D-loop; other site 637382010416 H-loop/switch region; other site 637382010417 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 637382010418 ATP cone domain; Region: ATP-cone; pfam03477 637382010419 Class III ribonucleotide reductase; Region: RNR_III; cd01675 637382010420 effector binding site; other site 637382010421 active site 637382010422 Zn binding site [ion binding]; other site 637382010423 glycine loop; other site 637382010424 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 637382010425 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 637382010426 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 637382010427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637382010428 DNA-binding site [nucleotide binding]; DNA binding site 637382010429 UTRA domain; Region: UTRA; pfam07702 637382010430 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnG; COG3624 637382010431 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 637382010432 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 637382010433 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 637382010434 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 637382010435 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382010436 Walker A/P-loop; other site 637382010437 ATP binding site [chemical binding]; other site 637382010438 Q-loop/lid; other site 637382010439 ABC transporter signature motif; other site 637382010440 Walker B; other site 637382010441 D-loop; other site 637382010442 H-loop/switch region; other site 637382010443 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637382010444 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 637382010445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382010446 Walker A/P-loop; other site 637382010447 ATP binding site [chemical binding]; other site 637382010448 Q-loop/lid; other site 637382010449 ABC transporter signature motif; other site 637382010450 Walker B; other site 637382010451 D-loop; other site 637382010452 H-loop/switch region; other site 637382010453 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 637382010454 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 637382010455 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 637382010456 active site 637382010457 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 637382010458 Guanylate kinase; Region: Guanylate_kin; pfam00625 637382010459 active site 637382010460 putative hydrolase; Provisional; Region: PRK02113 637382010461 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 637382010462 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 637382010463 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 637382010464 NAD binding site [chemical binding]; other site 637382010465 active site 637382010466 hypothetical protein; Provisional; Region: PRK03467 637382010467 Alginate lyase; Region: Alginate_lyase; pfam05426 637382010468 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 637382010469 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 637382010470 Walker A/P-loop; other site 637382010471 ATP binding site [chemical binding]; other site 637382010472 Q-loop/lid; other site 637382010473 ABC transporter signature motif; other site 637382010474 Walker B; other site 637382010475 D-loop; other site 637382010476 H-loop/switch region; other site 637382010477 TOBE domain; Region: TOBE_2; pfam08402 637382010478 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637382010479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382010480 dimer interface [polypeptide binding]; other site 637382010481 conserved gate region; other site 637382010482 putative PBP binding loops; other site 637382010483 ABC-ATPase subunit interface; other site 637382010484 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 637382010485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382010486 dimer interface [polypeptide binding]; other site 637382010487 putative PBP binding loops; other site 637382010488 ABC-ATPase subunit interface; other site 637382010489 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637382010490 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637382010491 Alginate lyase; Region: Alginate_lyase; pfam05426 637382010492 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 637382010493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637382010494 Coenzyme A binding pocket [chemical binding]; other site 637382010495 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 637382010496 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 637382010497 Peptidase family U32; Region: Peptidase_U32; pfam01136 637382010498 putative protease; Provisional; Region: PRK15447 637382010499 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 637382010500 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 637382010501 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 637382010502 Protein export membrane protein; Region: SecD_SecF; cl14618 637382010503 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 637382010504 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382010505 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382010506 hypothetical protein; Provisional; Region: PRK10508 637382010507 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 637382010508 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 637382010509 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 637382010510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637382010511 non-specific DNA binding site [nucleotide binding]; other site 637382010512 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637382010513 salt bridge; other site 637382010514 sequence-specific DNA binding site [nucleotide binding]; other site 637382010515 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 637382010516 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 637382010517 ATP binding site [chemical binding]; other site 637382010518 Mg++ binding site [ion binding]; other site 637382010519 motif III; other site 637382010520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382010521 nucleotide binding region [chemical binding]; other site 637382010522 ATP-binding site [chemical binding]; other site 637382010523 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 637382010524 putative RNA binding site [nucleotide binding]; other site 637382010525 Cold shock protein DEAD box A; Region: DEADboxA; pfam12343 637382010526 lipoprotein NlpI; Provisional; Region: PRK11189 637382010527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637382010528 binding surface 637382010529 TPR motif; other site 637382010530 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 637382010531 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 637382010532 trimer interface [polypeptide binding]; other site 637382010533 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 637382010534 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 637382010535 RNase E interface [polypeptide binding]; other site 637382010536 trimer interface [polypeptide binding]; other site 637382010537 active site 637382010538 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 637382010539 putative nucleic acid binding region [nucleotide binding]; other site 637382010540 G-X-X-G motif; other site 637382010541 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 637382010542 RNA binding site [nucleotide binding]; other site 637382010543 domain interface; other site 637382010544 putative transposase OrfB; Reviewed; Region: PHA02517 637382010545 HTH-like domain; Region: HTH_21; pfam13276 637382010546 Integrase core domain; Region: rve; pfam00665 637382010547 Integrase core domain; Region: rve_2; pfam13333 637382010548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637382010549 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382010550 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382010551 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 637382010552 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 637382010553 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 637382010554 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 637382010555 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 637382010556 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 637382010557 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 637382010558 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 637382010559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382010560 Walker A motif; other site 637382010561 ATP binding site [chemical binding]; other site 637382010562 Walker B motif; other site 637382010563 arginine finger; other site 637382010564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382010565 Walker A motif; other site 637382010566 ATP binding site [chemical binding]; other site 637382010567 Walker B motif; other site 637382010568 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637382010569 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 637382010570 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 637382010571 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 637382010572 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 637382010573 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 637382010574 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 637382010575 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 637382010576 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 637382010577 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 637382010578 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 637382010579 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 637382010580 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 637382010581 ImpA domain protein; Region: DUF3702; pfam12486 637382010582 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 637382010583 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637382010584 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 637382010585 Uncharacterized conserved protein [Function unknown]; Region: COG5435 637382010586 PAAR motif; Region: PAAR_motif; pfam05488 637382010587 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637382010588 RHS Repeat; Region: RHS_repeat; pfam05593 637382010589 RHS Repeat; Region: RHS_repeat; pfam05593 637382010590 RHS Repeat; Region: RHS_repeat; cl11982 637382010591 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637382010592 RHS protein; Region: RHS; pfam03527 637382010593 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637382010594 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 637382010595 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 637382010596 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637382010597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637382010598 non-specific DNA binding site [nucleotide binding]; other site 637382010599 salt bridge; other site 637382010600 sequence-specific DNA binding site [nucleotide binding]; other site 637382010601 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 637382010602 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637382010603 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 637382010604 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 637382010605 Uncharacterized conserved protein [Function unknown]; Region: COG5435 637382010606 PAAR motif; Region: PAAR_motif; pfam05488 637382010607 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637382010608 RHS Repeat; Region: RHS_repeat; pfam05593 637382010609 RHS Repeat; Region: RHS_repeat; pfam05593 637382010610 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637382010611 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637382010612 RHS protein; Region: RHS; pfam03527 637382010613 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637382010614 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 637382010615 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 637382010616 AP (apurinic/apyrimidinic) site pocket; other site 637382010617 DNA interaction; other site 637382010618 Metal-binding active site; metal-binding site 637382010619 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637382010620 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637382010621 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637382010622 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637382010623 Helix-turn-helix domain; Region: HTH_18; pfam12833 637382010624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382010625 ABC-type ribose transport system, auxiliary component [Carbohydrate transport and metabolism]; Region: RbsD; COG1869 637382010626 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 637382010627 substrate binding site [chemical binding]; other site 637382010628 dimer interface [polypeptide binding]; other site 637382010629 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637382010630 ATP binding site [chemical binding]; other site 637382010631 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 637382010632 intersubunit interface [polypeptide binding]; other site 637382010633 active site 637382010634 catalytic residue [active] 637382010635 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 637382010636 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637382010637 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382010638 substrate binding pocket [chemical binding]; other site 637382010639 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 637382010640 membrane-bound complex binding site; other site 637382010641 hinge residues; other site 637382010642 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 637382010643 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 637382010644 active site 637382010645 dimer interface [polypeptide binding]; other site 637382010646 non-prolyl cis peptide bond; other site 637382010647 insertion regions; other site 637382010648 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637382010649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382010650 dimer interface [polypeptide binding]; other site 637382010651 conserved gate region; other site 637382010652 putative PBP binding loops; other site 637382010653 ABC-ATPase subunit interface; other site 637382010654 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 637382010655 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 637382010656 Walker A/P-loop; other site 637382010657 ATP binding site [chemical binding]; other site 637382010658 Q-loop/lid; other site 637382010659 ABC transporter signature motif; other site 637382010660 Walker B; other site 637382010661 D-loop; other site 637382010662 H-loop/switch region; other site 637382010663 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 637382010664 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 637382010665 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 637382010666 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 637382010667 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 637382010668 putative acyl-acceptor binding pocket; other site 637382010669 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 637382010670 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 637382010671 ligand binding site [chemical binding]; other site 637382010672 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637382010673 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382010674 Walker A/P-loop; other site 637382010675 ATP binding site [chemical binding]; other site 637382010676 Q-loop/lid; other site 637382010677 ABC transporter signature motif; other site 637382010678 Walker B; other site 637382010679 D-loop; other site 637382010680 H-loop/switch region; other site 637382010681 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382010682 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382010683 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382010684 TM-ABC transporter signature motif; other site 637382010685 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382010686 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382010687 TM-ABC transporter signature motif; other site 637382010688 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 637382010689 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 637382010690 N- and C-terminal domain interface [polypeptide binding]; other site 637382010691 active site 637382010692 MgATP binding site [chemical binding]; other site 637382010693 catalytic site [active] 637382010694 metal binding site [ion binding]; metal-binding site 637382010695 carbohydrate binding site [chemical binding]; other site 637382010696 putative homodimer interface [polypeptide binding]; other site 637382010697 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 637382010698 putative active site [active] 637382010699 putative S-transferase; Provisional; Region: PRK11752 637382010700 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 637382010701 C-terminal domain interface [polypeptide binding]; other site 637382010702 GSH binding site (G-site) [chemical binding]; other site 637382010703 dimer interface [polypeptide binding]; other site 637382010704 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 637382010705 dimer interface [polypeptide binding]; other site 637382010706 N-terminal domain interface [polypeptide binding]; other site 637382010707 active site 637382010708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 637382010709 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 637382010710 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382010711 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 637382010712 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 637382010713 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 637382010714 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 637382010715 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 637382010716 potential frameshift: common BLAST hit: gi|294505245|ref|YP_003569307.1| putative metabolite transport protein 637382010717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382010718 metabolite-proton symporter; Region: 2A0106; TIGR00883 637382010719 Transcriptional regulators [Transcription]; Region: GntR; COG1802 637382010720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637382010721 DNA-binding site [nucleotide binding]; DNA binding site 637382010722 FCD domain; Region: FCD; pfam07729 637382010723 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 637382010724 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 637382010725 FMN binding site [chemical binding]; other site 637382010726 active site 637382010727 catalytic residues [active] 637382010728 substrate binding site [chemical binding]; other site 637382010729 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 637382010730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 637382010731 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 637382010732 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 637382010733 Na binding site [ion binding]; other site 637382010734 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 637382010735 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637382010736 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 637382010737 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 637382010738 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 637382010739 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 637382010740 carboxyltransferase (CT) interaction site; other site 637382010741 biotinylation site [posttranslational modification]; other site 637382010742 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 637382010743 Dehydroquinase class II; Region: DHquinase_II; pfam01220 637382010744 active site 637382010745 trimer interface [polypeptide binding]; other site 637382010746 dimer interface [polypeptide binding]; other site 637382010747 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 637382010748 TMAO/DMSO reductase; Reviewed; Region: PRK05363 637382010749 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 637382010750 Moco binding site; other site 637382010751 metal coordination site [ion binding]; other site 637382010752 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 637382010753 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 637382010754 NADP binding site [chemical binding]; other site 637382010755 dimer interface [polypeptide binding]; other site 637382010756 regulatory protein CsrD; Provisional; Region: PRK11059 637382010757 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637382010758 metal binding site [ion binding]; metal-binding site 637382010759 active site 637382010760 I-site; other site 637382010761 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637382010762 rod shape-determining protein MreB; Provisional; Region: PRK13927 637382010763 MreB and similar proteins; Region: MreB_like; cd10225 637382010764 nucleotide binding site [chemical binding]; other site 637382010765 Mg binding site [ion binding]; other site 637382010766 putative protofilament interaction site [polypeptide binding]; other site 637382010767 RodZ interaction site [polypeptide binding]; other site 637382010768 rod shape-determining protein MreC; Region: mreC; TIGR00219 637382010769 rod shape-determining protein MreC; Region: MreC; pfam04085 637382010770 rod shape-determining protein MreD; Provisional; Region: PRK11060 637382010771 Maf-like protein; Region: Maf; pfam02545 637382010772 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 637382010773 active site 637382010774 dimer interface [polypeptide binding]; other site 637382010775 ribonuclease G; Provisional; Region: PRK11712 637382010776 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 637382010777 homodimer interface [polypeptide binding]; other site 637382010778 oligonucleotide binding site [chemical binding]; other site 637382010779 hypothetical protein; Provisional; Region: PRK10899 637382010780 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 637382010781 nitrilase; Region: PLN02798 637382010782 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 637382010783 putative active site [active] 637382010784 catalytic triad [active] 637382010785 dimer interface [polypeptide binding]; other site 637382010786 protease TldD; Provisional; Region: tldD; PRK10735 637382010787 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637382010788 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637382010789 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637382010790 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637382010791 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 637382010792 active site 637382010793 catalytic residues [active] 637382010794 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 637382010795 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 637382010796 Family description; Region: VCBS; pfam13517 637382010797 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 637382010798 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 637382010799 potential frameshift: common BLAST hit: gi|145597602|ref|YP_001161678.1| toxin subunit 637382010800 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 637382010801 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637382010802 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382010803 transcriptional regulator; Provisional; Region: PRK10632 637382010804 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382010805 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 637382010806 putative effector binding pocket; other site 637382010807 dimerization interface [polypeptide binding]; other site 637382010808 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 637382010809 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382010810 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382010811 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 637382010812 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 637382010813 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 637382010814 tetramerization interface [polypeptide binding]; other site 637382010815 NAD(P) binding site [chemical binding]; other site 637382010816 catalytic residues [active] 637382010817 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 637382010818 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 637382010819 active site 637382010820 hypothetical protein; Provisional; Region: PRK05255 637382010821 peptidase PmbA; Provisional; Region: PRK11040 637382010822 Soluble cytochrome b562 [Energy production and conversion]; Region: CybC; COG3783 637382010823 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 637382010824 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 637382010825 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 637382010826 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 637382010827 Ca binding site [ion binding]; other site 637382010828 active site 637382010829 catalytic site [active] 637382010830 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 637382010831 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637382010832 active site turn [active] 637382010833 phosphorylation site [posttranslational modification] 637382010834 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637382010835 trehalose repressor; Provisional; Region: treR; PRK09492 637382010836 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382010837 DNA binding site [nucleotide binding] 637382010838 domain linker motif; other site 637382010839 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 637382010840 dimerization interface [polypeptide binding]; other site 637382010841 ligand binding site [chemical binding]; other site 637382010842 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 637382010843 dimer interface [polypeptide binding]; other site 637382010844 putative inhibitory loop; other site 637382010845 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 637382010846 homotrimer interaction site [polypeptide binding]; other site 637382010847 putative active site [active] 637382010848 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 637382010849 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 637382010850 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 637382010851 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 637382010852 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637382010853 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 637382010854 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 637382010855 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637382010856 active site 637382010857 phosphorylation site [posttranslational modification] 637382010858 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 637382010859 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 637382010860 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 637382010861 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 637382010862 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 637382010863 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 637382010864 Walker A/P-loop; other site 637382010865 ATP binding site [chemical binding]; other site 637382010866 Q-loop/lid; other site 637382010867 ABC transporter signature motif; other site 637382010868 Walker B; other site 637382010869 D-loop; other site 637382010870 H-loop/switch region; other site 637382010871 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 637382010872 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 637382010873 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 637382010874 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 637382010875 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 637382010876 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 637382010877 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 637382010878 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 637382010879 putative active site [active] 637382010880 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 637382010881 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 637382010882 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 637382010883 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 637382010884 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 637382010885 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 637382010886 Walker A/P-loop; other site 637382010887 ATP binding site [chemical binding]; other site 637382010888 Q-loop/lid; other site 637382010889 ABC transporter signature motif; other site 637382010890 Walker B; other site 637382010891 D-loop; other site 637382010892 H-loop/switch region; other site 637382010893 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 637382010894 conserved hypothetical integral membrane protein; Region: TIGR00056 637382010895 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 637382010896 mce related protein; Region: MCE; pfam02470 637382010897 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 637382010898 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 637382010899 anti sigma factor interaction site; other site 637382010900 regulatory phosphorylation site [posttranslational modification]; other site 637382010901 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 637382010902 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 637382010903 hinge; other site 637382010904 active site 637382010905 serine endoprotease; Provisional; Region: PRK10898 637382010906 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 637382010907 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637382010908 protein binding site [polypeptide binding]; other site 637382010909 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382010910 serine endoprotease; Provisional; Region: PRK10139 637382010911 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 637382010912 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637382010913 protein binding site [polypeptide binding]; other site 637382010914 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637382010915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 637382010916 hypothetical protein; Provisional; Region: PRK11677 637382010917 Predicted ATPase [General function prediction only]; Region: COG1485 637382010918 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 637382010919 23S rRNA interface [nucleotide binding]; other site 637382010920 L3 interface [polypeptide binding]; other site 637382010921 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 637382010922 stringent starvation protein A; Provisional; Region: sspA; PRK09481 637382010923 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 637382010924 C-terminal domain interface [polypeptide binding]; other site 637382010925 putative GSH binding site (G-site) [chemical binding]; other site 637382010926 dimer interface [polypeptide binding]; other site 637382010927 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 637382010928 dimer interface [polypeptide binding]; other site 637382010929 N-terminal domain interface [polypeptide binding]; other site 637382010930 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 637382010931 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 637382010932 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637382010933 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 637382010934 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637382010935 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 637382010936 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 637382010937 active site 637382010938 dimer interface [polypeptide binding]; other site 637382010939 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 637382010940 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 637382010941 active site 637382010942 FMN binding site [chemical binding]; other site 637382010943 substrate binding site [chemical binding]; other site 637382010944 3Fe-4S cluster binding site [ion binding]; other site 637382010945 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 637382010946 domain interface; other site 637382010947 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 637382010948 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382010949 FeS/SAM binding site; other site 637382010950 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 637382010951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637382010952 putative active site [active] 637382010953 heme pocket [chemical binding]; other site 637382010954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382010955 dimer interface [polypeptide binding]; other site 637382010956 phosphorylation site [posttranslational modification] 637382010957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382010958 ATP binding site [chemical binding]; other site 637382010959 Mg2+ binding site [ion binding]; other site 637382010960 G-X-G motif; other site 637382010961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382010962 active site 637382010963 phosphorylation site [posttranslational modification] 637382010964 intermolecular recognition site; other site 637382010965 dimerization interface [polypeptide binding]; other site 637382010966 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637382010967 putative binding surface; other site 637382010968 active site 637382010969 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 637382010970 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 637382010971 conserved cys residue [active] 637382010972 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 637382010973 Transglycosylase; Region: Transgly; cl17702 637382010974 outer membrane lipoprotein; Provisional; Region: PRK11023 637382010975 BON domain; Region: BON; pfam04972 637382010976 BON domain; Region: BON; cl02771 637382010977 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 637382010978 dimer interface [polypeptide binding]; other site 637382010979 active site 637382010980 hypothetical protein; Reviewed; Region: PRK12497 637382010981 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 637382010982 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 637382010983 putative ligand binding site [chemical binding]; other site 637382010984 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 637382010985 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 637382010986 putative SAM binding site [chemical binding]; other site 637382010987 putative homodimer interface [polypeptide binding]; other site 637382010988 Pirin-related protein [General function prediction only]; Region: COG1741 637382010989 Pirin; Region: Pirin; pfam02678 637382010990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382010991 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 637382010992 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637382010993 dimerization interface [polypeptide binding]; other site 637382010994 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 637382010995 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 637382010996 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 637382010997 putative dimer interface [polypeptide binding]; other site 637382010998 N-terminal domain interface [polypeptide binding]; other site 637382010999 putative substrate binding pocket (H-site) [chemical binding]; other site 637382011000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 637382011001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 637382011002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382011003 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382011004 DNA-binding interface [nucleotide binding]; DNA binding site 637382011005 Integrase core domain; Region: rve; pfam00665 637382011006 Predicted esterase [General function prediction only]; Region: COG0400 637382011007 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637382011008 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 637382011009 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 637382011010 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 637382011011 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 637382011012 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382011013 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 637382011014 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 637382011015 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 637382011016 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 637382011017 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 637382011018 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 637382011019 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 637382011020 Hemerythrin-like domain; Region: Hr-like; cd12108 637382011021 Fe binding site [ion binding]; other site 637382011022 potential frameshift: common BLAST hit: gi|294505343|ref|YP_003569405.1| 2',3'-cyclic-nucleotide 2'-phosphodiesterase 637382011023 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637382011024 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 637382011025 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637382011026 active site 637382011027 metal binding site [ion binding]; metal-binding site 637382011028 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 637382011029 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 637382011030 active site 637382011031 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 637382011032 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637382011033 Domain of unknown function DUF21; Region: DUF21; pfam01595 637382011034 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637382011035 Transporter associated domain; Region: CorC_HlyC; smart01091 637382011036 methionine sulfoxide reductase A; Provisional; Region: PRK00058 637382011037 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 637382011038 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 637382011039 Surface antigen; Region: Bac_surface_Ag; pfam01103 637382011040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 637382011041 Family of unknown function (DUF490); Region: DUF490; pfam04357 637382011042 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 637382011043 putative active site pocket [active] 637382011044 dimerization interface [polypeptide binding]; other site 637382011045 putative catalytic residue [active] 637382011046 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 637382011047 dimer interface [polypeptide binding]; other site 637382011048 substrate binding site [chemical binding]; other site 637382011049 metal binding sites [ion binding]; metal-binding site 637382011050 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 637382011051 AMP binding site [chemical binding]; other site 637382011052 metal binding site [ion binding]; metal-binding site 637382011053 active site 637382011054 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 637382011055 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637382011056 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637382011057 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637382011058 arginine repressor; Provisional; Region: PRK05066 637382011059 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 637382011060 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 637382011061 malate dehydrogenase; Provisional; Region: PRK05086 637382011062 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 637382011063 NAD binding site [chemical binding]; other site 637382011064 dimerization interface [polypeptide binding]; other site 637382011065 Substrate binding site [chemical binding]; other site 637382011066 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 637382011067 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 637382011068 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 637382011069 substrate binding pocket [chemical binding]; other site 637382011070 chain length determination region; other site 637382011071 substrate-Mg2+ binding site; other site 637382011072 catalytic residues [active] 637382011073 aspartate-rich region 1; other site 637382011074 active site lid residues [active] 637382011075 aspartate-rich region 2; other site 637382011076 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 637382011077 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 637382011078 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 637382011079 EamA-like transporter family; Region: EamA; pfam00892 637382011080 GTPase CgtA; Reviewed; Region: obgE; PRK12298 637382011081 GTP1/OBG; Region: GTP1_OBG; pfam01018 637382011082 Obg GTPase; Region: Obg; cd01898 637382011083 G1 box; other site 637382011084 GTP/Mg2+ binding site [chemical binding]; other site 637382011085 Switch I region; other site 637382011086 G2 box; other site 637382011087 G3 box; other site 637382011088 Switch II region; other site 637382011089 G4 box; other site 637382011090 G5 box; other site 637382011091 sensor protein BasS/PmrB; Provisional; Region: PRK10755 637382011092 HAMP domain; Region: HAMP; pfam00672 637382011093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382011094 dimer interface [polypeptide binding]; other site 637382011095 phosphorylation site [posttranslational modification] 637382011096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382011097 ATP binding site [chemical binding]; other site 637382011098 Mg2+ binding site [ion binding]; other site 637382011099 G-X-G motif; other site 637382011100 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 637382011101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382011102 active site 637382011103 phosphorylation site [posttranslational modification] 637382011104 intermolecular recognition site; other site 637382011105 dimerization interface [polypeptide binding]; other site 637382011106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382011107 DNA binding site [nucleotide binding] 637382011108 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 637382011109 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 637382011110 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 637382011111 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 637382011112 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 637382011113 RNA-binding protein YhbY; Provisional; Region: PRK10343 637382011114 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 637382011115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382011116 S-adenosylmethionine binding site [chemical binding]; other site 637382011117 FtsH Extracellular; Region: FtsH_ext; pfam06480 637382011118 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 637382011119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382011120 Walker A motif; other site 637382011121 ATP binding site [chemical binding]; other site 637382011122 Walker B motif; other site 637382011123 arginine finger; other site 637382011124 Peptidase family M41; Region: Peptidase_M41; pfam01434 637382011125 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 637382011126 dihydropteroate synthase; Region: DHPS; TIGR01496 637382011127 substrate binding pocket [chemical binding]; other site 637382011128 dimer interface [polypeptide binding]; other site 637382011129 inhibitor binding site; inhibition site 637382011130 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 637382011131 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 637382011132 active site 637382011133 substrate binding site [chemical binding]; other site 637382011134 metal binding site [ion binding]; metal-binding site 637382011135 ribosome maturation protein RimP; Reviewed; Region: PRK00092 637382011136 Sm and related proteins; Region: Sm_like; cl00259 637382011137 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 637382011138 putative oligomer interface [polypeptide binding]; other site 637382011139 putative RNA binding site [nucleotide binding]; other site 637382011140 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 637382011141 NusA N-terminal domain; Region: NusA_N; pfam08529 637382011142 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 637382011143 RNA binding site [nucleotide binding]; other site 637382011144 homodimer interface [polypeptide binding]; other site 637382011145 NusA-like KH domain; Region: KH_5; pfam13184 637382011146 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 637382011147 G-X-X-G motif; other site 637382011148 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 637382011149 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 637382011150 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 637382011151 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 637382011152 translation initiation factor IF-2; Validated; Region: infB; PRK05306 637382011153 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 637382011154 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 637382011155 G1 box; other site 637382011156 putative GEF interaction site [polypeptide binding]; other site 637382011157 GTP/Mg2+ binding site [chemical binding]; other site 637382011158 Switch I region; other site 637382011159 G2 box; other site 637382011160 G3 box; other site 637382011161 Switch II region; other site 637382011162 G4 box; other site 637382011163 G5 box; other site 637382011164 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 637382011165 Translation-initiation factor 2; Region: IF-2; pfam11987 637382011166 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 637382011167 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 637382011168 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 637382011169 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 637382011170 RNA binding site [nucleotide binding]; other site 637382011171 active site 637382011172 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 637382011173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637382011174 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382011175 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382011176 putative transposase OrfB; Reviewed; Region: PHA02517 637382011177 HTH-like domain; Region: HTH_21; pfam13276 637382011178 Integrase core domain; Region: rve; pfam00665 637382011179 Integrase core domain; Region: rve_2; pfam13333 637382011180 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 637382011181 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 637382011182 Protein of unknown function (DUF877); Region: DUF877; pfam05943 637382011183 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 637382011184 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 637382011185 maltose regulon periplasmic protein; Provisional; Region: PRK10564 637382011186 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 637382011187 trimer interface; other site 637382011188 sugar binding site [chemical binding]; other site 637382011189 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 637382011190 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 637382011191 Walker A/P-loop; other site 637382011192 ATP binding site [chemical binding]; other site 637382011193 Q-loop/lid; other site 637382011194 ABC transporter signature motif; other site 637382011195 Walker B; other site 637382011196 D-loop; other site 637382011197 H-loop/switch region; other site 637382011198 TOBE domain; Region: TOBE_2; pfam08402 637382011199 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 637382011200 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637382011201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382011202 dimer interface [polypeptide binding]; other site 637382011203 conserved gate region; other site 637382011204 putative PBP binding loops; other site 637382011205 ABC-ATPase subunit interface; other site 637382011206 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637382011207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382011208 dimer interface [polypeptide binding]; other site 637382011209 conserved gate region; other site 637382011210 putative PBP binding loops; other site 637382011211 ABC-ATPase subunit interface; other site 637382011212 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 637382011213 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 637382011214 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 637382011215 active site 637382011216 dimer interface [polypeptide binding]; other site 637382011217 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 637382011218 dimer interface [polypeptide binding]; other site 637382011219 active site 637382011220 aspartate kinase III; Validated; Region: PRK09084 637382011221 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 637382011222 nucleotide binding site [chemical binding]; other site 637382011223 substrate binding site [chemical binding]; other site 637382011224 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 637382011225 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 637382011226 dimer interface [polypeptide binding]; other site 637382011227 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 637382011228 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 637382011229 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 637382011230 haemagglutination activity domain; Region: Haemagg_act; pfam05860 637382011231 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382011232 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382011233 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 637382011234 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382011235 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382011236 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637382011237 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 637382011238 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 637382011239 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 637382011240 substrate binding pocket [chemical binding]; other site 637382011241 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 637382011242 B12 binding site [chemical binding]; other site 637382011243 cobalt ligand [ion binding]; other site 637382011244 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 637382011245 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 637382011246 Bacterial transcriptional regulator; Region: IclR; pfam01614 637382011247 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 637382011248 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 637382011249 isocitrate lyase; Provisional; Region: PRK15063 637382011250 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 637382011251 tetramer interface [polypeptide binding]; other site 637382011252 active site 637382011253 Mg2+/Mn2+ binding site [ion binding]; other site 637382011254 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 637382011255 malate synthase A; Region: malate_syn_A; TIGR01344 637382011256 active site 637382011257 homoserine O-succinyltransferase; Provisional; Region: PRK05368 637382011258 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 637382011259 proposed active site lysine [active] 637382011260 conserved cys residue [active] 637382011261 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 637382011262 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 637382011263 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 637382011264 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 637382011265 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 637382011266 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 637382011267 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 637382011268 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 637382011269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 637382011270 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 637382011271 Active_site [active] 637382011272 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 637382011273 substrate binding site [chemical binding]; other site 637382011274 active site 637382011275 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 637382011276 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 637382011277 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 637382011278 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 637382011279 putative NADH binding site [chemical binding]; other site 637382011280 putative active site [active] 637382011281 nudix motif; other site 637382011282 putative metal binding site [ion binding]; other site 637382011283 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 637382011284 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 637382011285 ThiC-associated domain; Region: ThiC-associated; pfam13667 637382011286 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 637382011287 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 637382011288 thiamine phosphate binding site [chemical binding]; other site 637382011289 active site 637382011290 pyrophosphate binding site [ion binding]; other site 637382011291 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 637382011292 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 637382011293 ATP binding site [chemical binding]; other site 637382011294 substrate interface [chemical binding]; other site 637382011295 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 637382011296 ThiS interaction site; other site 637382011297 putative active site [active] 637382011298 tetramer interface [polypeptide binding]; other site 637382011299 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 637382011300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637382011301 FeS/SAM binding site; other site 637382011302 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 637382011303 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382011304 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 637382011305 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 637382011306 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 637382011307 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 637382011308 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 637382011309 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 637382011310 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 637382011311 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 637382011312 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 637382011313 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 637382011314 DNA binding site [nucleotide binding] 637382011315 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 637382011316 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 637382011317 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 637382011318 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 637382011319 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 637382011320 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 637382011321 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 637382011322 RPB3 interaction site [polypeptide binding]; other site 637382011323 RPB1 interaction site [polypeptide binding]; other site 637382011324 RPB11 interaction site [polypeptide binding]; other site 637382011325 RPB10 interaction site [polypeptide binding]; other site 637382011326 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 637382011327 core dimer interface [polypeptide binding]; other site 637382011328 peripheral dimer interface [polypeptide binding]; other site 637382011329 L10 interface [polypeptide binding]; other site 637382011330 L11 interface [polypeptide binding]; other site 637382011331 putative EF-Tu interaction site [polypeptide binding]; other site 637382011332 putative EF-G interaction site [polypeptide binding]; other site 637382011333 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 637382011334 23S rRNA interface [nucleotide binding]; other site 637382011335 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 637382011336 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 637382011337 mRNA/rRNA interface [nucleotide binding]; other site 637382011338 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 637382011339 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 637382011340 23S rRNA interface [nucleotide binding]; other site 637382011341 L7/L12 interface [polypeptide binding]; other site 637382011342 putative thiostrepton binding site; other site 637382011343 L25 interface [polypeptide binding]; other site 637382011344 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 637382011345 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 637382011346 putative homodimer interface [polypeptide binding]; other site 637382011347 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 637382011348 heterodimer interface [polypeptide binding]; other site 637382011349 homodimer interface [polypeptide binding]; other site 637382011350 elongation factor Tu; Reviewed; Region: PRK00049 637382011351 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 637382011352 G1 box; other site 637382011353 GEF interaction site [polypeptide binding]; other site 637382011354 GTP/Mg2+ binding site [chemical binding]; other site 637382011355 Switch I region; other site 637382011356 G2 box; other site 637382011357 G3 box; other site 637382011358 Switch II region; other site 637382011359 G4 box; other site 637382011360 G5 box; other site 637382011361 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 637382011362 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 637382011363 Antibiotic Binding Site [chemical binding]; other site 637382011364 transposase/IS protein; Provisional; Region: PRK09183 637382011365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382011366 Walker A motif; other site 637382011367 ATP binding site [chemical binding]; other site 637382011368 Walker B motif; other site 637382011369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382011370 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382011371 DNA-binding interface [nucleotide binding]; DNA binding site 637382011372 Integrase core domain; Region: rve; pfam00665 637382011373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637382011374 Coenzyme A binding pocket [chemical binding]; other site 637382011375 pantothenate kinase; Provisional; Region: PRK05439 637382011376 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 637382011377 ATP-binding site [chemical binding]; other site 637382011378 CoA-binding site [chemical binding]; other site 637382011379 Mg2+-binding site [ion binding]; other site 637382011380 Biotin operon repressor [Transcription]; Region: BirA; COG1654 637382011381 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 637382011382 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 637382011383 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 637382011384 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 637382011385 FAD binding domain; Region: FAD_binding_4; pfam01565 637382011386 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 637382011387 potassium transporter; Provisional; Region: PRK10750 637382011388 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 637382011389 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 637382011390 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 637382011391 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382011392 proline dipeptidase; Provisional; Region: PRK13607 637382011393 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 637382011394 active site 637382011395 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 637382011396 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 637382011397 substrate binding site [chemical binding]; other site 637382011398 oxyanion hole (OAH) forming residues; other site 637382011399 trimer interface [polypeptide binding]; other site 637382011400 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 637382011401 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 637382011402 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 637382011403 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 637382011404 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 637382011405 dimer interface [polypeptide binding]; other site 637382011406 active site 637382011407 FMN reductase; Validated; Region: fre; PRK08051 637382011408 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 637382011409 FAD binding pocket [chemical binding]; other site 637382011410 FAD binding motif [chemical binding]; other site 637382011411 phosphate binding motif [ion binding]; other site 637382011412 beta-alpha-beta structure motif; other site 637382011413 NAD binding pocket [chemical binding]; other site 637382011414 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 637382011415 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 637382011416 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 637382011417 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 637382011418 heterodimer interface [polypeptide binding]; other site 637382011419 homodimer interface [polypeptide binding]; other site 637382011420 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 637382011421 dimer interface [polypeptide binding]; other site 637382011422 allosteric magnesium binding site [ion binding]; other site 637382011423 active site 637382011424 aspartate-rich active site metal binding site; other site 637382011425 Schiff base residues; other site 637382011426 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 637382011427 transposase/IS protein; Provisional; Region: PRK09183 637382011428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382011429 Walker A motif; other site 637382011430 ATP binding site [chemical binding]; other site 637382011431 Walker B motif; other site 637382011432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382011433 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382011434 DNA-binding interface [nucleotide binding]; DNA binding site 637382011435 Integrase core domain; Region: rve; pfam00665 637382011436 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 637382011437 active site 637382011438 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 637382011439 sec-independent translocase; Provisional; Region: PRK01770 637382011440 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 637382011441 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 637382011442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 637382011443 SCP-2 sterol transfer family; Region: SCP2; pfam02036 637382011444 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 637382011445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382011446 S-adenosylmethionine binding site [chemical binding]; other site 637382011447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 637382011448 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 637382011449 RmuC family; Region: RmuC; pfam02646 637382011450 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637382011451 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 637382011452 Carbon starvation protein CstA; Region: CstA; pfam02554 637382011453 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 637382011454 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 637382011455 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 637382011456 uridine phosphorylase; Provisional; Region: PRK11178 637382011457 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 637382011458 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 637382011459 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 637382011460 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 637382011461 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 637382011462 THF binding site; other site 637382011463 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 637382011464 substrate binding site [chemical binding]; other site 637382011465 THF binding site; other site 637382011466 zinc-binding site [ion binding]; other site 637382011467 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 637382011468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382011469 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 637382011470 putative dimerization interface [polypeptide binding]; other site 637382011471 Predicted permeases [General function prediction only]; Region: COG0679 637382011472 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 637382011473 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 637382011474 putative active site [active] 637382011475 catalytic site [active] 637382011476 putative metal binding site [ion binding]; other site 637382011477 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 637382011478 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 637382011479 Walker A/P-loop; other site 637382011480 ATP binding site [chemical binding]; other site 637382011481 Q-loop/lid; other site 637382011482 ABC transporter signature motif; other site 637382011483 Walker B; other site 637382011484 D-loop; other site 637382011485 H-loop/switch region; other site 637382011486 TOBE domain; Region: TOBE_2; pfam08402 637382011487 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637382011488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382011489 dimer interface [polypeptide binding]; other site 637382011490 conserved gate region; other site 637382011491 putative PBP binding loops; other site 637382011492 ABC-ATPase subunit interface; other site 637382011493 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 637382011494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382011495 dimer interface [polypeptide binding]; other site 637382011496 conserved gate region; other site 637382011497 putative PBP binding loops; other site 637382011498 ABC-ATPase subunit interface; other site 637382011499 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637382011500 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 637382011501 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382011502 putative fimbrial protein TcfA; Provisional; Region: PRK15308 637382011503 putative fimbrial protein TcfA; Provisional; Region: PRK15308 637382011504 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 637382011505 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 637382011506 Walker A/P-loop; other site 637382011507 ATP binding site [chemical binding]; other site 637382011508 Q-loop/lid; other site 637382011509 ABC transporter signature motif; other site 637382011510 Walker B; other site 637382011511 D-loop; other site 637382011512 H-loop/switch region; other site 637382011513 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 637382011514 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 637382011515 Walker A/P-loop; other site 637382011516 ATP binding site [chemical binding]; other site 637382011517 Q-loop/lid; other site 637382011518 ABC transporter signature motif; other site 637382011519 Walker B; other site 637382011520 D-loop; other site 637382011521 H-loop/switch region; other site 637382011522 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 637382011523 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 637382011524 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 637382011525 TM-ABC transporter signature motif; other site 637382011526 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382011527 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 637382011528 TM-ABC transporter signature motif; other site 637382011529 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 637382011530 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 637382011531 dimerization interface [polypeptide binding]; other site 637382011532 ligand binding site [chemical binding]; other site 637382011533 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 637382011534 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382011535 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 637382011536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637382011537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637382011538 DNA binding residues [nucleotide binding] 637382011539 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 637382011540 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 637382011541 cell division protein FtsE; Provisional; Region: PRK10908 637382011542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382011543 Walker A/P-loop; other site 637382011544 ATP binding site [chemical binding]; other site 637382011545 Q-loop/lid; other site 637382011546 ABC transporter signature motif; other site 637382011547 Walker B; other site 637382011548 D-loop; other site 637382011549 H-loop/switch region; other site 637382011550 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 637382011551 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 637382011552 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 637382011553 P loop; other site 637382011554 GTP binding site [chemical binding]; other site 637382011555 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 637382011556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382011557 S-adenosylmethionine binding site [chemical binding]; other site 637382011558 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 637382011559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4517 637382011560 Predicted membrane protein [Function unknown]; Region: COG3714 637382011561 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 637382011562 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637382011563 metal-binding site [ion binding] 637382011564 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637382011565 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 637382011566 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 637382011567 CPxP motif; other site 637382011568 hypothetical protein; Provisional; Region: PRK11212 637382011569 hypothetical protein; Provisional; Region: PRK11615 637382011570 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 637382011571 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637382011572 Cysteine-rich domain; Region: CCG; pfam02754 637382011573 Cysteine-rich domain; Region: CCG; pfam02754 637382011574 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 637382011575 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 637382011576 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 637382011577 hydroxyglutarate oxidase; Provisional; Region: PRK11728 637382011578 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 637382011579 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 637382011580 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 637382011581 active site 637382011582 catalytic site [active] 637382011583 metal binding site [ion binding]; metal-binding site 637382011584 Viral enhancin protein; Region: Enhancin; pfam03272 637382011585 Viral enhancin protein; Region: Enhancin; pfam03272 637382011586 putative hydrolase; Provisional; Region: PRK10976 637382011587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382011588 active site 637382011589 motif I; other site 637382011590 motif II; other site 637382011591 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637382011592 lysophospholipase L2; Provisional; Region: PRK10749 637382011593 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 637382011594 LysE type translocator; Region: LysE; cl00565 637382011595 threonine efflux system; Provisional; Region: PRK10229 637382011596 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 637382011597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637382011598 ATP binding site [chemical binding]; other site 637382011599 putative Mg++ binding site [ion binding]; other site 637382011600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382011601 nucleotide binding region [chemical binding]; other site 637382011602 ATP-binding site [chemical binding]; other site 637382011603 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 637382011604 HRDC domain; Region: HRDC; pfam00570 637382011605 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 637382011606 substrate binding site [chemical binding]; other site 637382011607 dimerization interface [polypeptide binding]; other site 637382011608 active site 637382011609 calcium binding site [ion binding]; other site 637382011610 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 637382011611 CoenzymeA binding site [chemical binding]; other site 637382011612 subunit interaction site [polypeptide binding]; other site 637382011613 PHB binding site; other site 637382011614 EamA-like transporter family; Region: EamA; cl17759 637382011615 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 637382011616 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 637382011617 Cl binding site [ion binding]; other site 637382011618 oligomer interface [polypeptide binding]; other site 637382011619 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 637382011620 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 637382011621 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 637382011622 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 637382011623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637382011624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637382011625 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 637382011626 Part of AAA domain; Region: AAA_19; pfam13245 637382011627 Family description; Region: UvrD_C_2; pfam13538 637382011628 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 637382011629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382011630 motif II; other site 637382011631 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 637382011632 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637382011633 active site 637382011634 DNA binding site [nucleotide binding] 637382011635 Int/Topo IB signature motif; other site 637382011636 hypothetical protein; Provisional; Region: PRK10963 637382011637 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 637382011638 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 637382011639 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 637382011640 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 637382011641 putative iron binding site [ion binding]; other site 637382011642 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 637382011643 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 637382011644 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 637382011645 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 637382011646 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 637382011647 domain interfaces; other site 637382011648 active site 637382011649 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 637382011650 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 637382011651 active site 637382011652 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 637382011653 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 637382011654 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 637382011655 HemY protein N-terminus; Region: HemY_N; pfam07219 637382011656 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382011657 putative transport protein YifK; Provisional; Region: PRK10746 637382011658 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 637382011659 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 637382011660 putative common antigen polymerase; Provisional; Region: PRK02975 637382011661 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 637382011662 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 637382011663 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 637382011664 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 637382011665 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 637382011666 inhibitor-cofactor binding pocket; inhibition site 637382011667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382011668 catalytic residue [active] 637382011669 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 637382011670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637382011671 Coenzyme A binding pocket [chemical binding]; other site 637382011672 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 637382011673 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 637382011674 substrate binding site; other site 637382011675 tetramer interface; other site 637382011676 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 637382011677 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 637382011678 NAD binding site [chemical binding]; other site 637382011679 substrate binding site [chemical binding]; other site 637382011680 homodimer interface [polypeptide binding]; other site 637382011681 active site 637382011682 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 637382011683 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 637382011684 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 637382011685 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 637382011686 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 637382011687 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 637382011688 active site 637382011689 homodimer interface [polypeptide binding]; other site 637382011690 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 637382011691 Chain length determinant protein; Region: Wzz; cl15801 637382011692 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 637382011693 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 637382011694 Mg++ binding site [ion binding]; other site 637382011695 putative catalytic motif [active] 637382011696 substrate binding site [chemical binding]; other site 637382011697 transcription termination factor Rho; Provisional; Region: rho; PRK09376 637382011698 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 637382011699 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 637382011700 RNA binding site [nucleotide binding]; other site 637382011701 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 637382011702 multimer interface [polypeptide binding]; other site 637382011703 Walker A motif; other site 637382011704 ATP binding site [chemical binding]; other site 637382011705 Walker B motif; other site 637382011706 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637382011707 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 637382011708 catalytic residues [active] 637382011709 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 637382011710 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 637382011711 ATP binding site [chemical binding]; other site 637382011712 Mg++ binding site [ion binding]; other site 637382011713 motif III; other site 637382011714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382011715 nucleotide binding region [chemical binding]; other site 637382011716 ATP-binding site [chemical binding]; other site 637382011717 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 637382011718 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 637382011719 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 637382011720 Part of AAA domain; Region: AAA_19; pfam13245 637382011721 Family description; Region: UvrD_C_2; pfam13538 637382011722 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 637382011723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382011724 MULE transposase domain; Region: MULE; pfam10551 637382011725 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637382011726 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637382011727 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382011728 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637382011729 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637382011730 PapC N-terminal domain; Region: PapC_N; pfam13954 637382011731 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382011732 PapC C-terminal domain; Region: PapC_C; pfam13953 637382011733 Fimbrial protein; Region: Fimbrial; cl01416 637382011734 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637382011735 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382011736 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637382011737 S-type Pyocin; Region: Pyocin_S; pfam06958 637382011738 ketol-acid reductoisomerase; Validated; Region: PRK05225 637382011739 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 637382011740 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 637382011741 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 637382011742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382011743 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 637382011744 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 637382011745 putative dimerization interface [polypeptide binding]; other site 637382011746 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 637382011747 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 637382011748 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 637382011749 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 637382011750 threonine dehydratase; Reviewed; Region: PRK09224 637382011751 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 637382011752 tetramer interface [polypeptide binding]; other site 637382011753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382011754 catalytic residue [active] 637382011755 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 637382011756 putative Ile/Val binding site [chemical binding]; other site 637382011757 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 637382011758 putative Ile/Val binding site [chemical binding]; other site 637382011759 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 637382011760 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 637382011761 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 637382011762 homodimer interface [polypeptide binding]; other site 637382011763 substrate-cofactor binding pocket; other site 637382011764 catalytic residue [active] 637382011765 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 637382011766 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637382011767 PYR/PP interface [polypeptide binding]; other site 637382011768 dimer interface [polypeptide binding]; other site 637382011769 TPP binding site [chemical binding]; other site 637382011770 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637382011771 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 637382011772 TPP-binding site [chemical binding]; other site 637382011773 dimer interface [polypeptide binding]; other site 637382011774 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 637382011775 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 637382011776 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 637382011777 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 637382011778 hypothetical protein; Provisional; Region: PRK11027 637382011779 transcriptional regulator HdfR; Provisional; Region: PRK03601 637382011780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382011781 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637382011782 dimerization interface [polypeptide binding]; other site 637382011783 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382011784 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382011785 TM-ABC transporter signature motif; other site 637382011786 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382011787 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382011788 TM-ABC transporter signature motif; other site 637382011789 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637382011790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382011791 Walker A/P-loop; other site 637382011792 ATP binding site [chemical binding]; other site 637382011793 Q-loop/lid; other site 637382011794 ABC transporter signature motif; other site 637382011795 Walker B; other site 637382011796 D-loop; other site 637382011797 H-loop/switch region; other site 637382011798 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382011799 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 637382011800 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 637382011801 putative ligand binding site [chemical binding]; other site 637382011802 glutamate racemase; Provisional; Region: PRK00865 637382011803 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 637382011804 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637382011805 N-terminal plug; other site 637382011806 ligand-binding site [chemical binding]; other site 637382011807 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 637382011808 hypothetical protein; Provisional; Region: PRK11056 637382011809 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 637382011810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637382011811 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 637382011812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637382011813 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637382011814 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 637382011815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637382011816 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 637382011817 dimerization interface [polypeptide binding]; other site 637382011818 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 637382011819 catalytic triad [active] 637382011820 dimer interface [polypeptide binding]; other site 637382011821 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 637382011822 GSH binding site [chemical binding]; other site 637382011823 catalytic residues [active] 637382011824 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 637382011825 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637382011826 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637382011827 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 637382011828 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 637382011829 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 637382011830 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637382011831 HlyD family secretion protein; Region: HlyD_3; pfam13437 637382011832 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 637382011833 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 637382011834 Walker A/P-loop; other site 637382011835 ATP binding site [chemical binding]; other site 637382011836 Q-loop/lid; other site 637382011837 ABC transporter signature motif; other site 637382011838 Walker B; other site 637382011839 D-loop; other site 637382011840 H-loop/switch region; other site 637382011841 Heme-binding protein A (HasA); Region: HasA; pfam06438 637382011842 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 637382011843 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637382011844 N-terminal plug; other site 637382011845 ligand-binding site [chemical binding]; other site 637382011846 argininosuccinate lyase; Provisional; Region: PRK04833 637382011847 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 637382011848 active sites [active] 637382011849 tetramer interface [polypeptide binding]; other site 637382011850 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 637382011851 nucleotide binding site [chemical binding]; other site 637382011852 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 637382011853 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 637382011854 acetylornithine deacetylase; Provisional; Region: PRK05111 637382011855 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 637382011856 metal binding site [ion binding]; metal-binding site 637382011857 putative dimer interface [polypeptide binding]; other site 637382011858 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 637382011859 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 637382011860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637382011861 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382011862 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382011863 putative transposase OrfB; Reviewed; Region: PHA02517 637382011864 HTH-like domain; Region: HTH_21; pfam13276 637382011865 Integrase core domain; Region: rve; pfam00665 637382011866 Integrase core domain; Region: rve_2; pfam13333 637382011867 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 637382011868 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 637382011869 glycogen phosphorylase; Provisional; Region: PRK14986 637382011870 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 637382011871 homodimer interface [polypeptide binding]; other site 637382011872 active site pocket [active] 637382011873 glycogen synthase; Provisional; Region: glgA; PRK00654 637382011874 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 637382011875 ADP-binding pocket [chemical binding]; other site 637382011876 homodimer interface [polypeptide binding]; other site 637382011877 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 637382011878 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 637382011879 ligand binding site; other site 637382011880 oligomer interface; other site 637382011881 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 637382011882 sulfate 1 binding site; other site 637382011883 glycogen debranching enzyme; Provisional; Region: PRK03705 637382011884 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 637382011885 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 637382011886 active site 637382011887 catalytic site [active] 637382011888 glycogen branching enzyme; Provisional; Region: PRK05402 637382011889 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 637382011890 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 637382011891 active site 637382011892 catalytic site [active] 637382011893 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 637382011894 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 637382011895 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 637382011896 Histidine kinase; Region: His_kinase; pfam06580 637382011897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382011898 ATP binding site [chemical binding]; other site 637382011899 Mg2+ binding site [ion binding]; other site 637382011900 G-X-G motif; other site 637382011901 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637382011902 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 637382011903 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637382011904 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637382011905 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637382011906 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637382011907 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637382011908 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637382011909 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637382011910 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637382011911 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637382011912 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637382011913 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637382011914 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637382011915 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637382011916 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 637382011917 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 637382011918 putative antibiotic transporter; Provisional; Region: PRK10739 637382011919 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 637382011920 AAA domain; Region: AAA_33; pfam13671 637382011921 ATP-binding site [chemical binding]; other site 637382011922 Gluconate-6-phosphate binding site [chemical binding]; other site 637382011923 high-affinity gluconate transporter; Provisional; Region: PRK14984 637382011924 gluconate transporter; Region: gntP; TIGR00791 637382011925 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 637382011926 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637382011927 DNA binding site [nucleotide binding] 637382011928 domain linker motif; other site 637382011929 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 637382011930 putative ligand binding site [chemical binding]; other site 637382011931 putative dimerization interface [polypeptide binding]; other site 637382011932 Pirin-related protein [General function prediction only]; Region: COG1741 637382011933 Pirin; Region: Pirin; pfam02678 637382011934 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637382011935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382011936 active site 637382011937 phosphorylation site [posttranslational modification] 637382011938 intermolecular recognition site; other site 637382011939 dimerization interface [polypeptide binding]; other site 637382011940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637382011941 DNA binding site [nucleotide binding] 637382011942 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 637382011943 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637382011944 substrate binding site [chemical binding]; other site 637382011945 ATP binding site [chemical binding]; other site 637382011946 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 637382011947 intersubunit interface [polypeptide binding]; other site 637382011948 active site 637382011949 zinc binding site [ion binding]; other site 637382011950 Na+ binding site [ion binding]; other site 637382011951 ABC-type sugar transport system, auxiliary component [General function prediction only]; Region: COG3822 637382011952 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 637382011953 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 637382011954 putative ligand binding site [chemical binding]; other site 637382011955 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382011956 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382011957 TM-ABC transporter signature motif; other site 637382011958 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637382011959 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382011960 Walker A/P-loop; other site 637382011961 ATP binding site [chemical binding]; other site 637382011962 Q-loop/lid; other site 637382011963 ABC transporter signature motif; other site 637382011964 Walker B; other site 637382011965 D-loop; other site 637382011966 H-loop/switch region; other site 637382011967 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382011968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 637382011969 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382011970 dimerization interface [polypeptide binding]; other site 637382011971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637382011972 dimer interface [polypeptide binding]; other site 637382011973 phosphorylation site [posttranslational modification] 637382011974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382011975 ATP binding site [chemical binding]; other site 637382011976 Mg2+ binding site [ion binding]; other site 637382011977 G-X-G motif; other site 637382011978 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 637382011979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382011980 active site 637382011981 phosphorylation site [posttranslational modification] 637382011982 intermolecular recognition site; other site 637382011983 dimerization interface [polypeptide binding]; other site 637382011984 Predicted flavoproteins [General function prediction only]; Region: COG2081 637382011985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637382011986 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 637382011987 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 637382011988 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382011989 universal stress protein UspB; Provisional; Region: PRK04960 637382011990 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637382011991 Ligand Binding Site [chemical binding]; other site 637382011992 glutamate dehydrogenase; Provisional; Region: PRK09414 637382011993 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 637382011994 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 637382011995 NAD(P) binding site [chemical binding]; other site 637382011996 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 637382011997 active site 637382011998 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 637382011999 putative methyltransferase; Provisional; Region: PRK10742 637382012000 oligopeptidase A; Provisional; Region: PRK10911 637382012001 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 637382012002 active site 637382012003 Zn binding site [ion binding]; other site 637382012004 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 637382012005 glutathione reductase; Validated; Region: PRK06116 637382012006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637382012007 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637382012008 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637382012009 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 637382012010 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 637382012011 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 637382012012 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 637382012013 fructuronate transporter; Provisional; Region: PRK10034; cl15264 637382012014 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 637382012015 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 637382012016 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 637382012017 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 637382012018 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 637382012019 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 637382012020 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637382012021 Autotransporter beta-domain; Region: Autotransporter; smart00869 637382012022 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 637382012023 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 637382012024 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 637382012025 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 637382012026 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637382012027 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637382012028 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 637382012029 substrate binding site [chemical binding]; other site 637382012030 ATP binding site [chemical binding]; other site 637382012031 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 637382012032 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 637382012033 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637382012034 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 637382012035 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 637382012036 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 637382012037 sugar binding site [chemical binding]; other site 637382012038 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 637382012039 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 637382012040 biofilm formation regulator HmsP; Provisional; Region: PRK11829 637382012041 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637382012042 metal binding site [ion binding]; metal-binding site 637382012043 active site 637382012044 I-site; other site 637382012045 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637382012046 endo-1,4-D-glucanase; Provisional; Region: PRK11097 637382012047 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 637382012048 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382012049 Walker A/P-loop; other site 637382012050 ATP binding site [chemical binding]; other site 637382012051 Q-loop/lid; other site 637382012052 ABC transporter signature motif; other site 637382012053 Walker B; other site 637382012054 D-loop; other site 637382012055 H-loop/switch region; other site 637382012056 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 637382012057 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 637382012058 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637382012059 Walker A/P-loop; other site 637382012060 ATP binding site [chemical binding]; other site 637382012061 Q-loop/lid; other site 637382012062 ABC transporter signature motif; other site 637382012063 Walker B; other site 637382012064 D-loop; other site 637382012065 H-loop/switch region; other site 637382012066 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 637382012067 dipeptide transporter; Provisional; Region: PRK10913 637382012068 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637382012069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382012070 dimer interface [polypeptide binding]; other site 637382012071 conserved gate region; other site 637382012072 putative PBP binding loops; other site 637382012073 ABC-ATPase subunit interface; other site 637382012074 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637382012075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382012076 dimer interface [polypeptide binding]; other site 637382012077 conserved gate region; other site 637382012078 putative PBP binding loops; other site 637382012079 ABC-ATPase subunit interface; other site 637382012080 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 637382012081 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 637382012082 peptide binding site [polypeptide binding]; other site 637382012083 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 637382012084 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 637382012085 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 637382012086 regulatory protein UhpC; Provisional; Region: PRK11663 637382012087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382012088 putative substrate translocation pore; other site 637382012089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382012090 Histidine kinase; Region: HisKA_3; pfam07730 637382012091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382012092 ATP binding site [chemical binding]; other site 637382012093 Mg2+ binding site [ion binding]; other site 637382012094 G-X-G motif; other site 637382012095 transposase/IS protein; Provisional; Region: PRK09183 637382012096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382012097 Walker A motif; other site 637382012098 ATP binding site [chemical binding]; other site 637382012099 Walker B motif; other site 637382012100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382012101 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382012102 DNA-binding interface [nucleotide binding]; DNA binding site 637382012103 Integrase core domain; Region: rve; pfam00665 637382012104 MASE1; Region: MASE1; pfam05231 637382012105 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 637382012106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637382012107 active site 637382012108 phosphorylation site [posttranslational modification] 637382012109 intermolecular recognition site; other site 637382012110 dimerization interface [polypeptide binding]; other site 637382012111 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637382012112 DNA binding residues [nucleotide binding] 637382012113 dimerization interface [polypeptide binding]; other site 637382012114 phosphoethanolamine transferase; Provisional; Region: PRK11560 637382012115 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 637382012116 Sulfatase; Region: Sulfatase; pfam00884 637382012117 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 637382012118 putative proline-specific permease; Provisional; Region: proY; PRK10580 637382012119 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 637382012120 active sites [active] 637382012121 tetramer interface [polypeptide binding]; other site 637382012122 urocanate hydratase; Provisional; Region: PRK05414 637382012123 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 637382012124 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 637382012125 dimer interface [polypeptide binding]; other site 637382012126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382012127 catalytic residue [active] 637382012128 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637382012129 active site 637382012130 hypothetical protein; Provisional; Region: PRK07206 637382012131 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 637382012132 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 637382012133 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 637382012134 putative ligand binding residues [chemical binding]; other site 637382012135 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637382012136 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382012137 ABC-ATPase subunit interface; other site 637382012138 dimer interface [polypeptide binding]; other site 637382012139 putative PBP binding regions; other site 637382012140 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637382012141 ABC-ATPase subunit interface; other site 637382012142 dimer interface [polypeptide binding]; other site 637382012143 putative PBP binding regions; other site 637382012144 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 637382012145 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637382012146 Walker A/P-loop; other site 637382012147 ATP binding site [chemical binding]; other site 637382012148 Q-loop/lid; other site 637382012149 ABC transporter signature motif; other site 637382012150 Walker B; other site 637382012151 D-loop; other site 637382012152 H-loop/switch region; other site 637382012153 Virulence protein [General function prediction only]; Region: COG3943 637382012154 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 637382012155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637382012156 non-specific DNA binding site [nucleotide binding]; other site 637382012157 salt bridge; other site 637382012158 sequence-specific DNA binding site [nucleotide binding]; other site 637382012159 integrase; Provisional; Region: PRK09692 637382012160 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 637382012161 active site 637382012162 Int/Topo IB signature motif; other site 637382012163 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 637382012164 putative dimerization interface [polypeptide binding]; other site 637382012165 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637382012166 putative ligand binding site [chemical binding]; other site 637382012167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382012168 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637382012169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382012170 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 637382012171 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637382012172 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637382012173 TM-ABC transporter signature motif; other site 637382012174 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 637382012175 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637382012176 Walker A/P-loop; other site 637382012177 ATP binding site [chemical binding]; other site 637382012178 Q-loop/lid; other site 637382012179 ABC transporter signature motif; other site 637382012180 Walker B; other site 637382012181 D-loop; other site 637382012182 H-loop/switch region; other site 637382012183 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637382012184 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 637382012185 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 637382012186 putative ligand binding site [chemical binding]; other site 637382012187 xylose isomerase; Provisional; Region: PRK05474 637382012188 xylose isomerase; Region: xylose_isom_A; TIGR02630 637382012189 xylulokinase; Provisional; Region: PRK15027 637382012190 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 637382012191 N- and C-terminal domain interface [polypeptide binding]; other site 637382012192 active site 637382012193 MgATP binding site [chemical binding]; other site 637382012194 catalytic site [active] 637382012195 metal binding site [ion binding]; metal-binding site 637382012196 xylulose binding site [chemical binding]; other site 637382012197 homodimer interface [polypeptide binding]; other site 637382012198 Fimbrial protein; Region: Fimbrial; pfam00419 637382012199 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637382012200 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382012201 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637382012202 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382012203 PapC C-terminal domain; Region: PapC_C; pfam13953 637382012204 PapC N-terminal domain; Region: PapC_N; pfam13954 637382012205 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382012206 Fimbrial protein; Region: Fimbrial; cl01416 637382012207 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 637382012208 Acyltransferase family; Region: Acyl_transf_3; pfam01757 637382012209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637382012210 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382012211 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382012212 putative transposase OrfB; Reviewed; Region: PHA02517 637382012213 HTH-like domain; Region: HTH_21; pfam13276 637382012214 Integrase core domain; Region: rve; pfam00665 637382012215 Integrase core domain; Region: rve_2; pfam13333 637382012216 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 637382012217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637382012218 putative substrate translocation pore; other site 637382012219 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 637382012220 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 637382012221 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 637382012222 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 637382012223 G1 box; other site 637382012224 putative GEF interaction site [polypeptide binding]; other site 637382012225 GTP/Mg2+ binding site [chemical binding]; other site 637382012226 Switch I region; other site 637382012227 G2 box; other site 637382012228 G3 box; other site 637382012229 Switch II region; other site 637382012230 G4 box; other site 637382012231 G5 box; other site 637382012232 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 637382012233 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 637382012234 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 637382012235 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 637382012236 selenocysteine synthase; Provisional; Region: PRK04311 637382012237 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 637382012238 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 637382012239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637382012240 catalytic residue [active] 637382012241 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 637382012242 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 637382012243 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 637382012244 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 637382012245 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 637382012246 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 637382012247 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 637382012248 molybdopterin cofactor binding site; other site 637382012249 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 637382012250 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 637382012251 molybdopterin cofactor binding site; other site 637382012252 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 637382012253 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 637382012254 superoxide dismutase; Provisional; Region: PRK10925 637382012255 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 637382012256 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 637382012257 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637382012258 dimerization interface [polypeptide binding]; other site 637382012259 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637382012260 dimer interface [polypeptide binding]; other site 637382012261 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 637382012262 putative CheW interface [polypeptide binding]; other site 637382012263 Electron transfer DM13; Region: DM13; pfam10517 637382012264 hypothetical protein; Provisional; Region: PRK11020 637382012265 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 637382012266 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 637382012267 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 637382012268 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 637382012269 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 637382012270 Similar to Yersinia pestis PTS system, mannitol-specific IIABC component 637382012271 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 637382012272 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 637382012273 DALR anticodon binding domain; Region: DALR_1; pfam05746 637382012274 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 637382012275 dimer interface [polypeptide binding]; other site 637382012276 motif 1; other site 637382012277 active site 637382012278 motif 2; other site 637382012279 motif 3; other site 637382012280 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 637382012281 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 637382012282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637382012283 Coenzyme A binding pocket [chemical binding]; other site 637382012284 putative outer membrane lipoprotein; Provisional; Region: PRK10510 637382012285 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637382012286 ligand binding site [chemical binding]; other site 637382012287 Predicted transcriptional regulator [Transcription]; Region: COG2345 637382012288 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 637382012289 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 637382012290 dimerization interface [polypeptide binding]; other site 637382012291 ligand binding site [chemical binding]; other site 637382012292 NADP binding site [chemical binding]; other site 637382012293 catalytic site [active] 637382012294 alpha-amylase; Reviewed; Region: malS; PRK09505 637382012295 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 637382012296 active site 637382012297 catalytic site [active] 637382012298 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 637382012299 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637382012300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382012301 homodimer interface [polypeptide binding]; other site 637382012302 catalytic residue [active] 637382012303 putative transporter; Validated; Region: PRK03818 637382012304 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 637382012305 TrkA-C domain; Region: TrkA_C; pfam02080 637382012306 TrkA-C domain; Region: TrkA_C; pfam02080 637382012307 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 637382012308 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 637382012309 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 637382012310 putative dimer interface [polypeptide binding]; other site 637382012311 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 637382012312 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 637382012313 putative dimer interface [polypeptide binding]; other site 637382012314 hypothetical protein; Provisional; Region: PRK11616 637382012315 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 637382012316 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 637382012317 hypothetical protein; Provisional; Region: PRK06815 637382012318 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 637382012319 tetramer interface [polypeptide binding]; other site 637382012320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637382012321 catalytic residue [active] 637382012322 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 637382012323 ornithine cyclodeaminase; Validated; Region: PRK06823 637382012324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637382012325 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382012326 Helix-turn-helix domain; Region: HTH_28; pfam13518 637382012327 putative transposase OrfB; Reviewed; Region: PHA02517 637382012328 HTH-like domain; Region: HTH_21; pfam13276 637382012329 Integrase core domain; Region: rve; pfam00665 637382012330 Integrase core domain; Region: rve_2; pfam13333 637382012331 sugar phosphate phosphatase; Provisional; Region: PRK10513 637382012332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382012333 active site 637382012334 motif I; other site 637382012335 motif II; other site 637382012336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382012337 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 637382012338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637382012339 Mg2+ binding site [ion binding]; other site 637382012340 G-X-G motif; other site 637382012341 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 637382012342 anchoring element; other site 637382012343 dimer interface [polypeptide binding]; other site 637382012344 ATP binding site [chemical binding]; other site 637382012345 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 637382012346 active site 637382012347 putative metal-binding site [ion binding]; other site 637382012348 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 637382012349 recombination protein F; Reviewed; Region: recF; PRK00064 637382012350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382012351 Walker A/P-loop; other site 637382012352 ATP binding site [chemical binding]; other site 637382012353 Q-loop/lid; other site 637382012354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382012355 ABC transporter signature motif; other site 637382012356 Walker B; other site 637382012357 D-loop; other site 637382012358 H-loop/switch region; other site 637382012359 DNA polymerase III subunit beta; Validated; Region: PRK05643 637382012360 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 637382012361 putative DNA binding surface [nucleotide binding]; other site 637382012362 dimer interface [polypeptide binding]; other site 637382012363 beta-clamp/clamp loader binding surface; other site 637382012364 beta-clamp/translesion DNA polymerase binding surface; other site 637382012365 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 637382012366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 637382012367 Walker B motif; other site 637382012368 arginine finger; other site 637382012369 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 637382012370 DnaA box-binding interface [nucleotide binding]; other site 637382012371 DnaA N-terminal domain; Region: DnaA_N; pfam11638 637382012372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 637382012373 membrane protein insertase; Provisional; Region: PRK01318 637382012374 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 637382012375 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 637382012376 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 637382012377 trmE is a tRNA modification GTPase; Region: trmE; cd04164 637382012378 G1 box; other site 637382012379 GTP/Mg2+ binding site [chemical binding]; other site 637382012380 Switch I region; other site 637382012381 G2 box; other site 637382012382 Switch II region; other site 637382012383 G3 box; other site 637382012384 G4 box; other site 637382012385 G5 box; other site 637382012386 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 637382012387 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 637382012388 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 637382012389 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 637382012390 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 637382012391 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 637382012392 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 637382012393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637382012394 motif II; other site 637382012395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382012396 dimer interface [polypeptide binding]; other site 637382012397 conserved gate region; other site 637382012398 putative PBP binding loops; other site 637382012399 ABC-ATPase subunit interface; other site 637382012400 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637382012401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382012402 dimer interface [polypeptide binding]; other site 637382012403 conserved gate region; other site 637382012404 putative PBP binding loops; other site 637382012405 ABC-ATPase subunit interface; other site 637382012406 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637382012407 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382012408 substrate binding pocket [chemical binding]; other site 637382012409 membrane-bound complex binding site; other site 637382012410 hinge residues; other site 637382012411 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 637382012412 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 637382012413 transcriptional regulator PhoU; Provisional; Region: PRK11115 637382012414 PhoU domain; Region: PhoU; pfam01895 637382012415 PhoU domain; Region: PhoU; pfam01895 637382012416 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 637382012417 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 637382012418 Walker A/P-loop; other site 637382012419 ATP binding site [chemical binding]; other site 637382012420 Q-loop/lid; other site 637382012421 ABC transporter signature motif; other site 637382012422 Walker B; other site 637382012423 D-loop; other site 637382012424 H-loop/switch region; other site 637382012425 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 637382012426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382012427 dimer interface [polypeptide binding]; other site 637382012428 conserved gate region; other site 637382012429 putative PBP binding loops; other site 637382012430 ABC-ATPase subunit interface; other site 637382012431 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 637382012432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637382012433 dimer interface [polypeptide binding]; other site 637382012434 conserved gate region; other site 637382012435 putative PBP binding loops; other site 637382012436 ABC-ATPase subunit interface; other site 637382012437 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637382012438 substrate binding pocket [chemical binding]; other site 637382012439 membrane-bound complex binding site; other site 637382012440 hinge residues; other site 637382012441 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 637382012442 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 637382012443 glutaminase active site [active] 637382012444 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 637382012445 dimer interface [polypeptide binding]; other site 637382012446 active site 637382012447 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 637382012448 dimer interface [polypeptide binding]; other site 637382012449 active site 637382012450 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 637382012451 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 637382012452 Substrate binding site; other site 637382012453 Mg++ binding site; other site 637382012454 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 637382012455 active site 637382012456 substrate binding site [chemical binding]; other site 637382012457 CoA binding site [chemical binding]; other site 637382012458 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 637382012459 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 637382012460 gamma subunit interface [polypeptide binding]; other site 637382012461 epsilon subunit interface [polypeptide binding]; other site 637382012462 LBP interface [polypeptide binding]; other site 637382012463 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637382012464 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 637382012465 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 637382012466 alpha subunit interaction interface [polypeptide binding]; other site 637382012467 Walker A motif; other site 637382012468 ATP binding site [chemical binding]; other site 637382012469 Walker B motif; other site 637382012470 inhibitor binding site; inhibition site 637382012471 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637382012472 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 637382012473 core domain interface [polypeptide binding]; other site 637382012474 delta subunit interface [polypeptide binding]; other site 637382012475 epsilon subunit interface [polypeptide binding]; other site 637382012476 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 637382012477 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637382012478 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 637382012479 beta subunit interaction interface [polypeptide binding]; other site 637382012480 Walker A motif; other site 637382012481 ATP binding site [chemical binding]; other site 637382012482 Walker B motif; other site 637382012483 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637382012484 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 637382012485 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 637382012486 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 637382012487 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 637382012488 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 637382012489 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 637382012490 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 637382012491 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 637382012492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637382012493 S-adenosylmethionine binding site [chemical binding]; other site 637382012494 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 637382012495 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 637382012496 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 637382012497 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382012498 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382012499 DNA-binding interface [nucleotide binding]; DNA binding site 637382012500 Integrase core domain; Region: rve; pfam00665 637382012501 transposase/IS protein; Provisional; Region: PRK09183 637382012502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382012503 Walker A motif; other site 637382012504 ATP binding site [chemical binding]; other site 637382012505 Walker B motif; other site 637382012506 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 637382012507 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 637382012508 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 637382012509 Phage Tail Collar Domain; Region: Collar; pfam07484 637382012510 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 637382012511 Phage-related protein, tail component [Function unknown]; Region: COG4733 637382012512 Putative phage tail protein; Region: Phage-tail_3; pfam13550 637382012513 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637382012514 Interdomain contacts; other site 637382012515 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 637382012516 Fibronectin type III protein; Region: DUF3672; pfam12421 637382012517 Phage-related protein, tail component [Function unknown]; Region: COG4723 637382012518 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 637382012519 MPN+ (JAMM) motif; other site 637382012520 Zinc-binding site [ion binding]; other site 637382012521 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 637382012522 NlpC/P60 family; Region: NLPC_P60; pfam00877 637382012523 lambda-like phage minor tail protein L; Region: phage_tail_L; TIGR01600 637382012524 Phage-related protein [Function unknown]; Region: COG4718 637382012525 Mu-like prophage protein [General function prediction only]; Region: COG3941 637382012526 tape measure domain; Region: tape_meas_nterm; TIGR02675 637382012527 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 637382012528 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 637382012529 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 637382012530 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 637382012531 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 637382012532 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 637382012533 large terminase protein; Provisional; Region: 17; PHA02533 637382012534 Terminase-like family; Region: Terminase_6; pfam03237 637382012535 ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Region: COG2401 637382012536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382012537 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 637382012538 Walker A/P-loop; other site 637382012539 ATP binding site [chemical binding]; other site 637382012540 Q-loop/lid; other site 637382012541 ABC transporter signature motif; other site 637382012542 Walker B; other site 637382012543 D-loop; other site 637382012544 H-loop/switch region; other site 637382012545 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 637382012546 ParB-like nuclease domain; Region: ParBc; pfam02195 637382012547 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 637382012548 ParB-like nuclease domain; Region: ParBc; pfam02195 637382012549 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 637382012550 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637382012551 ATP binding site [chemical binding]; other site 637382012552 putative Mg++ binding site [ion binding]; other site 637382012553 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637382012554 nucleotide binding region [chemical binding]; other site 637382012555 ATP-binding site [chemical binding]; other site 637382012556 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 637382012557 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 637382012558 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637382012559 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 637382012560 active site 637382012561 putative DNA-binding cleft [nucleotide binding]; other site 637382012562 dimer interface [polypeptide binding]; other site 637382012563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382012564 endonuclease subunit; Provisional; Region: 46; PHA02562 637382012565 Walker A/P-loop; other site 637382012566 ATP binding site [chemical binding]; other site 637382012567 Q-loop/lid; other site 637382012568 ABC transporter signature motif; other site 637382012569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637382012570 ABC transporter signature motif; other site 637382012571 Walker B; other site 637382012572 D-loop; other site 637382012573 H-loop/switch region; other site 637382012574 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 637382012575 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 637382012576 active site 637382012577 metal binding site [ion binding]; metal-binding site 637382012578 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 637382012579 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 637382012580 substrate binding pocket [chemical binding]; other site 637382012581 membrane-bound complex binding site; other site 637382012582 hypothetical protein; Region: PHA02053 637382012583 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 637382012584 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 637382012585 SPFH domain / Band 7 family; Region: Band_7; pfam01145 637382012586 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 637382012587 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 637382012588 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637382012589 Walker A motif; other site 637382012590 ATP binding site [chemical binding]; other site 637382012591 Walker B motif; other site 637382012592 5'-3' exonuclease; Region: 53EXOc; smart00475 637382012593 PIN domain of bacteriophage T3, T4 RNase H, T5-5'nuclease, and homologs; Region: PIN_T4-like; cd09860 637382012594 active site 637382012595 metal binding site 1 [ion binding]; metal-binding site 637382012596 5' ssDNA interaction site; other site 637382012597 3' ssDNA interaction site; other site 637382012598 metal binding site 2 [ion binding]; metal-binding site 637382012599 H3TH domain of bacteriophage T3, T4 RNase H, T5-5' nucleases, and homologs; Region: H3TH_T4-like; cd09899 637382012600 DNA binding site [nucleotide binding] 637382012601 metal binding site [ion binding]; metal-binding site 637382012602 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 637382012603 PHP domain; Region: PHP; pfam02811 637382012604 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 637382012605 active site 637382012606 PHP Thumb interface [polypeptide binding]; other site 637382012607 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 637382012608 Uracil DNA glycosylase superfamily; Region: UDG; pfam03167 637382012609 MoxR-like ATPases [General function prediction only]; Region: COG0714 637382012610 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 637382012611 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 637382012612 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 637382012613 Cobalamin biosynthesis protein CobT VWA domain; Region: CobT_C; pfam11775 637382012614 metal ion-dependent adhesion site (MIDAS); other site 637382012615 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637382012616 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 637382012617 active site 637382012618 DNA binding site [nucleotide binding] 637382012619 Int/Topo IB signature motif; other site 637382012620 Caf1 Capsule antigen; Region: Antig_Caf1; pfam09255 637382012621 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637382012622 PapC N-terminal domain; Region: PapC_N; pfam13954 637382012623 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637382012624 PapC C-terminal domain; Region: PapC_C; pfam13953 637382012625 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637382012626 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637382012627 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637382012628 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637382012629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637382012630 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 637382012631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 637382012632 MULE transposase domain; Region: MULE; pfam10551 637382012633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637382012634 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637382012635 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637382012636 Uncharacterized conserved protein [Function unknown]; Region: COG5464 637382012637 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 637382012638 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 637382012639 Putative catalytic domain, repeat 1, of Yersinia pestis murine toxin-like proteins; Region: PLDc_Ymt_1; cd09150 637382012640 putative active site [active] 637382012641 catalytic site [active] 637382012642 Putative catalytic domain, repeat 2, of Yersinia pestis murine toxin-like proteins; Region: PLDc_Ymt_2; cd09151 637382012643 PLD-like domain; Region: PLDc_2; pfam13091 637382012644 putative active site [active] 637382012645 catalytic site [active] 637382012646 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 637382012647 PLD-like domain; Region: PLDc_2; pfam13091 637382012648 putative active site [active] 637382012649 catalytic site [active] 637382012650 Uncharacterized conserved protein [Function unknown]; Region: COG5464 637382012651 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 637382012652 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 637382012653 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637382012654 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 637382012655 catalytic residues [active] 637382012656 catalytic nucleophile [active] 637382012657 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 637382012658 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 637382012659 P-loop; other site 637382012660 Magnesium ion binding site [ion binding]; other site 637382012661 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637382012662 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 637382012663 ParB-like nuclease domain; Region: ParB; smart00470 637382012664 ParB family; Region: ParB; pfam08775 637382012665 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 637382012666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382012667 Walker A motif; other site 637382012668 ATP binding site [chemical binding]; other site 637382012669 Walker B motif; other site 637382012670 putative methylase; Provisional; Region: PRK13699 637382012671 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 637382012672 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 637382012673 Antirestriction protein [General function prediction only]; Region: ArdA; COG4734 637382012674 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 637382012675 ParB-like nuclease domain; Region: ParBc; pfam02195 637382012676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 637382012677 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637382012678 DNA-binding interface [nucleotide binding]; DNA binding site 637382012679 Integrase core domain; Region: rve; pfam00665 637382012680 transposase/IS protein; Provisional; Region: PRK09183 637382012681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637382012682 Walker A motif; other site 637382012683 ATP binding site [chemical binding]; other site 637382012684 Walker B motif; other site 637382012685 Pesticin Translocation And Receptor Binding Domain; Region: Pesticin_RB; cd12220 637382012686 TonB box [polypeptide binding]; other site 637382012687 outer membrane protease; Reviewed; Region: PRK12580 637382012688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637382012689 non-specific DNA binding site [nucleotide binding]; other site 637382012690 salt bridge; other site 637382012691 sequence-specific DNA binding site [nucleotide binding]; other site 637382012692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683