-- dump date 20140620_140950 -- class Genbank::misc_feature -- table misc_feature_note -- id note 229193000001 FMN-binding protein MioC; Provisional; Region: PRK09004 229193000002 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 229193000003 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 229193000004 putative DNA binding site [nucleotide binding]; other site 229193000005 putative Zn2+ binding site [ion binding]; other site 229193000006 AsnC family; Region: AsnC_trans_reg; pfam01037 229193000007 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 229193000008 motif 1; other site 229193000009 dimer interface [polypeptide binding]; other site 229193000010 active site 229193000011 motif 2; other site 229193000012 motif 3; other site 229193000013 hypothetical protein; Provisional; Region: yieM; PRK10997 229193000014 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 229193000015 metal ion-dependent adhesion site (MIDAS); other site 229193000016 regulatory ATPase RavA; Provisional; Region: PRK13531 229193000017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193000018 Walker A motif; other site 229193000019 ATP binding site [chemical binding]; other site 229193000020 Walker B motif; other site 229193000021 arginine finger; other site 229193000022 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 229193000023 ProfileScan match to entry PS50322 GLN_RICH_1, E-value 12.862 229193000024 ProfileScan match to entry PS50322 GLN_RICH_1, E-value 9.909 229193000025 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 229193000026 potassium uptake protein; Region: kup; TIGR00794 229193000027 probable transmembrane helix predicted by TMHMM2.0 229193000028 probable transmembrane helix predicted by TMHMM2.0 229193000029 probable transmembrane helix predicted by TMHMM2.0 229193000030 probable transmembrane helix predicted by TMHMM2.0 229193000031 probable transmembrane helix predicted by TMHMM2.0 229193000032 probable transmembrane helix predicted by TMHMM2.0 229193000033 probable transmembrane helix predicted by TMHMM2.0 229193000034 probable transmembrane helix predicted by TMHMM2.0 229193000035 probable transmembrane helix predicted by TMHMM2.0 229193000036 probable transmembrane helix predicted by TMHMM2.0 229193000037 probable transmembrane helix predicted by TMHMM2.0 229193000038 probable transmembrane helix predicted by TMHMM2.0 229193000039 D-ribose pyranase; Provisional; Region: PRK11797 229193000040 HMMPfam match to entry PF05025 RbsD_FucU, E-value 3.6e-77 229193000041 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 229193000042 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 229193000043 substrate binding site [chemical binding]; other site 229193000044 dimer interface [polypeptide binding]; other site 229193000045 ATP binding site [chemical binding]; other site 229193000046 BlastProDom match to entry PD023180 sp_P44331_RBSK_HAEIN, E-value 1e-22 229193000047 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 229193000048 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 229193000049 putative transporter; Provisional; Region: PRK10504 229193000050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193000051 putative substrate translocation pore; other site 229193000052 probable transmembrane helix predicted by TMHMM2.0 229193000053 probable transmembrane helix predicted by TMHMM2.0 229193000054 probable transmembrane helix predicted by TMHMM2.0 229193000055 probable transmembrane helix predicted by TMHMM2.0 229193000056 probable transmembrane helix predicted by TMHMM2.0 229193000057 probable transmembrane helix predicted by TMHMM2.0 229193000058 probable transmembrane helix predicted by TMHMM2.0 229193000059 probable transmembrane helix predicted by TMHMM2.0 229193000060 probable transmembrane helix predicted by TMHMM2.0 229193000061 probable transmembrane helix predicted by TMHMM2.0 229193000062 probable transmembrane helix predicted by TMHMM2.0 229193000063 probable transmembrane helix predicted by TMHMM2.0 229193000064 probable transmembrane helix predicted by TMHMM2.0 229193000065 probable transmembrane helix predicted by TMHMM2.0 229193000066 Transcriptional regulators [Transcription]; Region: FadR; COG2186 229193000067 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 229193000068 DNA-binding site [nucleotide binding]; DNA binding site 229193000069 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 229193000070 rRNA operon 229193000071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193000072 MULE transposase domain; Region: MULE; pfam10551 229193000073 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 229193000074 Walker A motif; other site 229193000075 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 229193000076 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 229193000077 GTP binding site; other site 229193000078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3084 229193000079 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 229193000080 serine/threonine protein kinase; Provisional; Region: PRK11768 229193000081 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 229193000082 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 229193000083 catalytic residues [active] 229193000084 hinge region; other site 229193000085 alpha helical domain; other site 229193000086 probable transmembrane helix predicted by TMHMM2.0 229193000087 DNA polymerase I; Provisional; Region: PRK05755 229193000088 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 229193000089 active site 229193000090 metal binding site 1 [ion binding]; metal-binding site 229193000091 putative 5' ssDNA interaction site; other site 229193000092 metal binding site 3; metal-binding site 229193000093 metal binding site 2 [ion binding]; metal-binding site 229193000094 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 229193000095 putative DNA binding site [nucleotide binding]; other site 229193000096 putative metal binding site [ion binding]; other site 229193000097 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 229193000098 active site 229193000099 catalytic site [active] 229193000100 substrate binding site [chemical binding]; other site 229193000101 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 229193000102 active site 229193000103 DNA binding site [nucleotide binding] 229193000104 catalytic site [active] 229193000105 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193000106 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 229193000107 G1 box; other site 229193000108 GTP/Mg2+ binding site [chemical binding]; other site 229193000109 Switch I region; other site 229193000110 G2 box; other site 229193000111 G3 box; other site 229193000112 Switch II region; other site 229193000113 G4 box; other site 229193000114 G5 box; other site 229193000115 Der GTPase activator; Provisional; Region: PRK05244 229193000116 HMMPfam match to entry PF04220 DUF414, E-value 4.7e-48 229193000117 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 229193000118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193000119 FeS/SAM binding site; other site 229193000120 HemN C-terminal domain; Region: HemN_C; pfam06969 229193000121 HMMPfam match to entry PF04055 Radical_SAM, E-value 3.7e-23 229193000122 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 229193000123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193000124 active site 229193000125 phosphorylation site [posttranslational modification] 229193000126 intermolecular recognition site; other site 229193000127 dimerization interface [polypeptide binding]; other site 229193000128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193000129 Walker A motif; other site 229193000130 ATP binding site [chemical binding]; other site 229193000131 Walker B motif; other site 229193000132 arginine finger; other site 229193000133 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 229193000134 ProfileScan match to entry PS50116 HTH_FIS_FAMILY, E-value 16.836 229193000135 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 229193000136 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 229193000137 dimer interface [polypeptide binding]; other site 229193000138 phosphorylation site [posttranslational modification] 229193000139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193000140 ATP binding site [chemical binding]; other site 229193000141 Mg2+ binding site [ion binding]; other site 229193000142 G-X-G motif; other site 229193000143 glutamine synthetase; Provisional; Region: glnA; PRK09469 229193000144 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 229193000145 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 229193000146 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 229193000147 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 229193000148 G1 box; other site 229193000149 putative GEF interaction site [polypeptide binding]; other site 229193000150 GTP/Mg2+ binding site [chemical binding]; other site 229193000151 Switch I region; other site 229193000152 G2 box; other site 229193000153 G3 box; other site 229193000154 Switch II region; other site 229193000155 G4 box; other site 229193000156 G5 box; other site 229193000157 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 229193000158 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 229193000159 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 229193000160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193000161 motif II; other site 229193000162 BlastProDom match to entry PD003038 sp_P32145_YIHX_ECOLI, E-value 4e-48 229193000163 hypothetical protein; Reviewed; Region: PRK01637 229193000164 probable transmembrane helix predicted by TMHMM2.0 229193000165 probable transmembrane helix predicted by TMHMM2.0 229193000166 probable transmembrane helix predicted by TMHMM2.0 229193000167 probable transmembrane helix predicted by TMHMM2.0 229193000168 probable transmembrane helix predicted by TMHMM2.0 229193000169 probable transmembrane helix predicted by TMHMM2.0 229193000170 probable transmembrane helix predicted by TMHMM2.0 229193000171 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 229193000172 putative active site [active] 229193000173 dimerization interface [polypeptide binding]; other site 229193000174 putative tRNAtyr binding site [nucleotide binding]; other site 229193000175 transposase/IS protein; Provisional; Region: PRK09183 229193000176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193000177 Walker A motif; other site 229193000178 ATP binding site [chemical binding]; other site 229193000179 Walker B motif; other site 229193000180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193000181 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193000182 DNA-binding interface [nucleotide binding]; DNA binding site 229193000183 Integrase core domain; Region: rve; pfam00665 229193000184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 229193000185 Coenzyme A binding pocket [chemical binding]; other site 229193000186 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 229193000187 probable transmembrane helix predicted by TMHMM2.0 229193000188 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 229193000189 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 229193000190 probable transmembrane helix predicted by TMHMM2.0 229193000191 probable transmembrane helix predicted by TMHMM2.0 229193000192 probable transmembrane helix predicted by TMHMM2.0 229193000193 BlastProDom match to entry PD005952 sp_Q9KX94_Q9KX94_ECO57, E-value 1e-06 229193000194 probable transmembrane helix predicted by TMHMM2.0 229193000195 probable transmembrane helix predicted by TMHMM2.0 229193000196 probable transmembrane helix predicted by TMHMM2.0 229193000197 probable transmembrane helix predicted by TMHMM2.0 229193000198 probable transmembrane helix predicted by TMHMM2.0 229193000199 probable transmembrane helix predicted by TMHMM2.0 229193000200 probable transmembrane helix predicted by TMHMM2.0 229193000201 probable transmembrane helix predicted by TMHMM2.0 229193000202 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 229193000203 probable transmembrane helix predicted by TMHMM2.0 229193000204 probable transmembrane helix predicted by TMHMM2.0 229193000205 probable transmembrane helix predicted by TMHMM2.0 229193000206 probable transmembrane helix predicted by TMHMM2.0 229193000207 probable transmembrane helix predicted by TMHMM2.0 229193000208 probable transmembrane helix predicted by TMHMM2.0 229193000209 probable transmembrane helix predicted by TMHMM2.0 229193000210 probable transmembrane helix predicted by TMHMM2.0 229193000211 probable transmembrane helix predicted by TMHMM2.0 229193000212 probable transmembrane helix predicted by TMHMM2.0 229193000213 probable transmembrane helix predicted by TMHMM2.0 229193000214 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 229193000215 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 229193000216 generic binding surface II; other site 229193000217 ssDNA binding site; other site 229193000218 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 229193000219 ATP binding site [chemical binding]; other site 229193000220 putative Mg++ binding site [ion binding]; other site 229193000221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193000222 nucleotide binding region [chemical binding]; other site 229193000223 ATP-binding site [chemical binding]; other site 229193000224 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 229193000225 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 229193000226 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 229193000227 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 229193000228 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 229193000229 Zn2+ binding site [ion binding]; other site 229193000230 Mg2+ binding site [ion binding]; other site 229193000231 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 229193000232 synthetase active site [active] 229193000233 NTP binding site [chemical binding]; other site 229193000234 metal binding site [ion binding]; metal-binding site 229193000235 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 229193000236 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 229193000237 HMMPfam match to entry PF04607 RelA_SpoT, E-value 4.7e-66 229193000238 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 229193000239 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 229193000240 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 229193000241 catalytic site [active] 229193000242 G-X2-G-X-G-K; other site 229193000243 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 229193000244 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 229193000245 nucleotide binding pocket [chemical binding]; other site 229193000246 K-X-D-G motif; other site 229193000247 catalytic site [active] 229193000248 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 229193000249 Predicted membrane protein [Function unknown]; Region: COG2860 229193000250 UPF0126 domain; Region: UPF0126; pfam03458 229193000251 UPF0126 domain; Region: UPF0126; pfam03458 229193000252 probable transmembrane helix predicted by TMHMM2.0 229193000253 probable transmembrane helix predicted by TMHMM2.0 229193000254 probable transmembrane helix predicted by TMHMM2.0 229193000255 probable transmembrane helix predicted by TMHMM2.0 229193000256 probable transmembrane helix predicted by TMHMM2.0 229193000257 probable transmembrane helix predicted by TMHMM2.0 229193000258 probable transmembrane helix predicted by TMHMM2.0 229193000259 hypothetical protein; Provisional; Region: PRK11820 229193000260 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 229193000261 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 229193000262 ribonuclease PH; Reviewed; Region: rph; PRK00173 229193000263 Ribonuclease PH; Region: RNase_PH_bact; cd11362 229193000264 hexamer interface [polypeptide binding]; other site 229193000265 active site 229193000266 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 229193000267 active site 229193000268 division inhibitor protein; Provisional; Region: slmA; PRK09480 229193000269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 229193000270 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 229193000271 trimer interface [polypeptide binding]; other site 229193000272 active site 229193000273 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 229193000274 Flavoprotein; Region: Flavoprotein; pfam02441 229193000275 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 229193000276 hypothetical protein; Reviewed; Region: PRK00024 229193000277 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 229193000278 MPN+ (JAMM) motif; other site 229193000279 Zinc-binding site [ion binding]; other site 229193000280 HMMPfam match to entry PF04002 RadC, E-value 2.9e-75 229193000281 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 229193000282 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 229193000283 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 229193000284 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 229193000285 DNA binding site [nucleotide binding] 229193000286 catalytic residue [active] 229193000287 H2TH interface [polypeptide binding]; other site 229193000288 putative catalytic residues [active] 229193000289 turnover-facilitating residue; other site 229193000290 intercalation triad [nucleotide binding]; other site 229193000291 8OG recognition residue [nucleotide binding]; other site 229193000292 putative reading head residues; other site 229193000293 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 229193000294 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 229193000295 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 229193000296 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 229193000297 active site 229193000298 (T/H)XGH motif; other site 229193000299 BlastProDom match to entry PD004081 sp_Q9X980_COAD_SERMA, E-value 4e-56 229193000300 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 229193000301 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 229193000302 putative metal binding site; other site 229193000303 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 229193000304 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 229193000305 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 229193000306 HMMPfam match to entry PF04413 Glycos_transf_N, E-value 5.7e-109 229193000307 probable transmembrane helix predicted by TMHMM2.0 229193000308 probable transmembrane helix predicted by TMHMM2.0 229193000309 probable transmembrane helix predicted by TMHMM2.0 229193000310 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 229193000311 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 229193000312 putative active site [active] 229193000313 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 229193000314 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 229193000315 putative active site [active] 229193000316 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 229193000317 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 229193000318 NADP binding site [chemical binding]; other site 229193000319 homopentamer interface [polypeptide binding]; other site 229193000320 substrate binding site [chemical binding]; other site 229193000321 active site 229193000322 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 229193000323 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 229193000324 substrate-cofactor binding pocket; other site 229193000325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193000326 catalytic residue [active] 229193000327 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 229193000328 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 229193000329 NAD(P) binding site [chemical binding]; other site 229193000330 BlastProDom match to entry PD135120 sp_Q97U21_Q97U21_SULSO, E-value 5e-07 229193000331 AmiB activator; Provisional; Region: PRK11637 229193000332 Peptidase family M23; Region: Peptidase_M23; pfam01551 229193000333 ProfileScan match to entry PS50322 GLN_RICH, E-value 9.267 229193000334 phosphoglyceromutase; Provisional; Region: PRK05434 229193000335 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 229193000336 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 229193000337 active site residue [active] 229193000338 BlastProDom match to entry PD033278 sp_P37688_YIBN_ECOLI, E-value 2e-22 229193000339 probable transmembrane helix predicted by TMHMM2.0 229193000340 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 229193000341 GSH binding site [chemical binding]; other site 229193000342 catalytic residues [active] 229193000343 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 229193000344 SecA binding site; other site 229193000345 Preprotein binding site; other site 229193000346 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 229193000347 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 229193000348 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 229193000349 serine acetyltransferase; Provisional; Region: cysE; PRK11132 229193000350 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 229193000351 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 229193000352 trimer interface [polypeptide binding]; other site 229193000353 active site 229193000354 substrate binding site [chemical binding]; other site 229193000355 CoA binding site [chemical binding]; other site 229193000356 putative rRNA methylase; Provisional; Region: PRK10358 229193000357 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 229193000358 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 229193000359 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193000360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193000361 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 229193000362 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 229193000363 DNA binding site [nucleotide binding] 229193000364 active site 229193000365 two-component sensor protein; Provisional; Region: cpxA; PRK09470 229193000366 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 229193000367 dimerization interface [polypeptide binding]; other site 229193000368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193000369 dimer interface [polypeptide binding]; other site 229193000370 phosphorylation site [posttranslational modification] 229193000371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193000372 ATP binding site [chemical binding]; other site 229193000373 Mg2+ binding site [ion binding]; other site 229193000374 G-X-G motif; other site 229193000375 probable transmembrane helix predicted by TMHMM2.0 229193000376 probable transmembrane helix predicted by TMHMM2.0 229193000377 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 229193000378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193000379 active site 229193000380 phosphorylation site [posttranslational modification] 229193000381 intermolecular recognition site; other site 229193000382 dimerization interface [polypeptide binding]; other site 229193000383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193000384 DNA binding site [nucleotide binding] 229193000385 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 229193000386 dimer interface [polypeptide binding]; other site 229193000387 Uncharacterized conserved protein [Function unknown]; Region: COG5464 229193000388 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 229193000389 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 229193000390 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 229193000391 probable transmembrane helix predicted by TMHMM2.0 229193000392 probable transmembrane helix predicted by TMHMM2.0 229193000393 probable transmembrane helix predicted by TMHMM2.0 229193000394 probable transmembrane helix predicted by TMHMM2.0 229193000395 probable transmembrane helix predicted by TMHMM2.0 229193000396 probable transmembrane helix predicted by TMHMM2.0 229193000397 6-phosphofructokinase; Provisional; Region: PRK03202 229193000398 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 229193000399 active site 229193000400 ADP/pyrophosphate binding site [chemical binding]; other site 229193000401 dimerization interface [polypeptide binding]; other site 229193000402 allosteric effector site; other site 229193000403 fructose-1,6-bisphosphate binding site; other site 229193000404 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 229193000405 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193000406 substrate binding pocket [chemical binding]; other site 229193000407 membrane-bound complex binding site; other site 229193000408 hinge residues; other site 229193000409 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 229193000410 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 229193000411 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 229193000412 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 229193000413 transmembrane helices; other site 229193000414 probable transmembrane helix predicted by TMHMM2.0 229193000415 probable transmembrane helix predicted by TMHMM2.0 229193000416 probable transmembrane helix predicted by TMHMM2.0 229193000417 probable transmembrane helix predicted by TMHMM2.0 229193000418 probable transmembrane helix predicted by TMHMM2.0 229193000419 probable transmembrane helix predicted by TMHMM2.0 229193000420 probable transmembrane helix predicted by TMHMM2.0 229193000421 probable transmembrane helix predicted by TMHMM2.0 229193000422 probable transmembrane helix predicted by TMHMM2.0 229193000423 probable transmembrane helix predicted by TMHMM2.0 229193000424 probable transmembrane helix predicted by TMHMM2.0 229193000425 highly similar to Yersinia pestis CO92 YPO0082 and Yersiniapestis KIM y0055; disrupted by the insertion of an IS100 element 229193000426 transposase/IS protein; Provisional; Region: PRK09183 229193000427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193000428 Walker A motif; other site 229193000429 ATP binding site [chemical binding]; other site 229193000430 Walker B motif; other site 229193000431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193000432 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193000433 DNA-binding interface [nucleotide binding]; DNA binding site 229193000434 Integrase core domain; Region: rve; pfam00665 229193000435 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 229193000436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193000437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193000438 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193000439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193000440 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 229193000441 dimerization interface [polypeptide binding]; other site 229193000442 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 229193000443 triosephosphate isomerase; Provisional; Region: PRK14567 229193000444 substrate binding site [chemical binding]; other site 229193000445 dimer interface [polypeptide binding]; other site 229193000446 catalytic triad [active] 229193000447 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 229193000448 probable transmembrane helix predicted by TMHMM2.0 229193000449 Predicted membrane protein [Function unknown]; Region: COG3152 229193000450 probable transmembrane helix predicted by TMHMM2.0 229193000451 probable transmembrane helix predicted by TMHMM2.0 229193000452 probable transmembrane helix predicted by TMHMM2.0 229193000453 probable transmembrane helix predicted by TMHMM2.0 229193000454 ferredoxin-NADP reductase; Provisional; Region: PRK10926 229193000455 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 229193000456 FAD binding pocket [chemical binding]; other site 229193000457 FAD binding motif [chemical binding]; other site 229193000458 phosphate binding motif [ion binding]; other site 229193000459 beta-alpha-beta structure motif; other site 229193000460 NAD binding pocket [chemical binding]; other site 229193000461 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 229193000462 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 229193000463 putative active site [active] 229193000464 glycerol kinase; Provisional; Region: glpK; PRK00047 229193000465 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 229193000466 N- and C-terminal domain interface [polypeptide binding]; other site 229193000467 active site 229193000468 MgATP binding site [chemical binding]; other site 229193000469 catalytic site [active] 229193000470 metal binding site [ion binding]; metal-binding site 229193000471 glycerol binding site [chemical binding]; other site 229193000472 homotetramer interface [polypeptide binding]; other site 229193000473 homodimer interface [polypeptide binding]; other site 229193000474 FBP binding site [chemical binding]; other site 229193000475 protein IIAGlc interface [polypeptide binding]; other site 229193000476 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 229193000477 amphipathic channel; other site 229193000478 Asn-Pro-Ala signature motifs; other site 229193000479 probable transmembrane helix predicted by TMHMM2.0 229193000480 probable transmembrane helix predicted by TMHMM2.0 229193000481 probable transmembrane helix predicted by TMHMM2.0 229193000482 probable transmembrane helix predicted by TMHMM2.0 229193000483 probable transmembrane helix predicted by TMHMM2.0 229193000484 probable transmembrane helix predicted by TMHMM2.0 229193000485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 229193000486 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193000487 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 229193000488 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 229193000489 putative active site [active] 229193000490 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 229193000491 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 229193000492 Walker A/P-loop; other site 229193000493 ATP binding site [chemical binding]; other site 229193000494 Q-loop/lid; other site 229193000495 ABC transporter signature motif; other site 229193000496 Walker B; other site 229193000497 D-loop; other site 229193000498 H-loop/switch region; other site 229193000499 probable transmembrane helix predicted by TMHMM2.0 229193000500 probable transmembrane helix predicted by TMHMM2.0 229193000501 probable transmembrane helix predicted by TMHMM2.0 229193000502 probable transmembrane helix predicted by TMHMM2.0 229193000503 probable transmembrane helix predicted by TMHMM2.0 229193000504 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 229193000505 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 229193000506 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193000507 probable transmembrane helix predicted by TMHMM2.0 229193000508 probable transmembrane helix predicted by TMHMM2.0 229193000509 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 229193000510 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 229193000511 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 229193000512 UbiA prenyltransferase family; Region: UbiA; pfam01040 229193000513 probable transmembrane helix predicted by TMHMM2.0 229193000514 probable transmembrane helix predicted by TMHMM2.0 229193000515 probable transmembrane helix predicted by TMHMM2.0 229193000516 probable transmembrane helix predicted by TMHMM2.0 229193000517 probable transmembrane helix predicted by TMHMM2.0 229193000518 probable transmembrane helix predicted by TMHMM2.0 229193000519 probable transmembrane helix predicted by TMHMM2.0 229193000520 probable transmembrane helix predicted by TMHMM2.0 229193000521 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 229193000522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193000523 Walker A motif; other site 229193000524 ATP binding site [chemical binding]; other site 229193000525 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 229193000526 Walker B motif; other site 229193000527 arginine finger; other site 229193000528 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 229193000529 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 229193000530 active site 229193000531 HslU subunit interaction site [polypeptide binding]; other site 229193000532 BlastProDom match to entry PD008385 sp_Q9K4Q6_Q9K4Q6_SALTY, E-value 3e-77 229193000533 probable transmembrane helix predicted by TMHMM2.0 229193000534 Sporulation related domain; Region: SPOR; cl10051 229193000535 cell division protein FtsN; Provisional; Region: PRK12757 229193000536 HMMPfam match to entry PF05036 SPOR, E-value 9.7e-08 229193000537 HMMPfam match to entry PF05036 SPOR, E-value 1.5e-06 229193000538 probable transmembrane helix predicted by TMHMM2.0 229193000539 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193000540 DNA binding site [nucleotide binding] 229193000541 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 229193000542 domain linker motif; other site 229193000543 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 229193000544 dimerization interface [polypeptide binding]; other site 229193000545 ligand binding site [chemical binding]; other site 229193000546 primosome assembly protein PriA; Validated; Region: PRK05580 229193000547 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 229193000548 ATP binding site [chemical binding]; other site 229193000549 putative Mg++ binding site [ion binding]; other site 229193000550 helicase superfamily c-terminal domain; Region: HELICc; smart00490 229193000551 ATP-binding site [chemical binding]; other site 229193000552 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 229193000553 Predicted membrane protein [Function unknown]; Region: COG4682 229193000554 yiaA/B two helix domain; Region: YiaAB; pfam05360 229193000555 yiaA/B two helix domain; Region: YiaAB; pfam05360 229193000556 probable transmembrane helix predicted by TMHMM2.0 229193000557 probable transmembrane helix predicted by TMHMM2.0 229193000558 probable transmembrane helix predicted by TMHMM2.0 229193000559 probable transmembrane helix predicted by TMHMM2.0 229193000560 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 229193000561 dimerization interface [polypeptide binding]; other site 229193000562 DNA binding site [nucleotide binding] 229193000563 corepressor binding sites; other site 229193000564 cystathionine gamma-synthase; Provisional; Region: PRK08045 229193000565 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 229193000566 homodimer interface [polypeptide binding]; other site 229193000567 substrate-cofactor binding pocket; other site 229193000568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193000569 catalytic residue [active] 229193000570 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 229193000571 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 229193000572 putative catalytic residues [active] 229193000573 putative nucleotide binding site [chemical binding]; other site 229193000574 putative aspartate binding site [chemical binding]; other site 229193000575 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 229193000576 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 229193000577 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 229193000578 FAD binding site [chemical binding]; other site 229193000579 putative transposase OrfB; Reviewed; Region: PHA02517 229193000580 HTH-like domain; Region: HTH_21; pfam13276 229193000581 Integrase core domain; Region: rve; pfam00665 229193000582 Integrase core domain; Region: rve_2; pfam13333 229193000583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 229193000584 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193000585 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193000586 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 229193000587 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 229193000588 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 229193000589 intramembrane serine protease GlpG; Provisional; Region: PRK10907 229193000590 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 229193000591 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 229193000592 probable transmembrane helix predicted by TMHMM2.0 229193000593 probable transmembrane helix predicted by TMHMM2.0 229193000594 probable transmembrane helix predicted by TMHMM2.0 229193000595 probable transmembrane helix predicted by TMHMM2.0 229193000596 probable transmembrane helix predicted by TMHMM2.0 229193000597 probable transmembrane helix predicted by TMHMM2.0 229193000598 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 229193000599 active site residue [active] 229193000600 transcriptional regulator MalT; Provisional; Region: PRK04841 229193000601 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193000602 DNA binding residues [nucleotide binding] 229193000603 dimerization interface [polypeptide binding]; other site 229193000604 Contains Glycosyl transferase, family 35 (Interpro|IPR000811, (GO:0005975)) . Contains Glycosyl transferase, family 35 (Interpro|IPR000811, (GO:0005975)) 229193000605 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 229193000606 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 229193000607 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 229193000608 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 229193000609 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 229193000610 DNA utilization protein GntX; Provisional; Region: PRK11595 229193000611 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 229193000612 active site 229193000613 ProfileScan match to entry PS50311 CYS_RICH, E-value 9.927 229193000614 carboxylesterase BioH; Provisional; Region: PRK10349 229193000615 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 229193000616 FeoC like transcriptional regulator; Region: FeoC; cl17677 229193000617 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 229193000618 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 229193000619 G1 box; other site 229193000620 GTP/Mg2+ binding site [chemical binding]; other site 229193000621 Switch I region; other site 229193000622 G2 box; other site 229193000623 G3 box; other site 229193000624 Switch II region; other site 229193000625 G4 box; other site 229193000626 G5 box; other site 229193000627 Nucleoside recognition; Region: Gate; pfam07670 229193000628 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 229193000629 Nucleoside recognition; Region: Gate; pfam07670 229193000630 probable transmembrane helix predicted by TMHMM2.0 229193000631 probable transmembrane helix predicted by TMHMM2.0 229193000632 probable transmembrane helix predicted by TMHMM2.0 229193000633 probable transmembrane helix predicted by TMHMM2.0 229193000634 probable transmembrane helix predicted by TMHMM2.0 229193000635 probable transmembrane helix predicted by TMHMM2.0 229193000636 probable transmembrane helix predicted by TMHMM2.0 229193000637 probable transmembrane helix predicted by TMHMM2.0 229193000638 probable transmembrane helix predicted by TMHMM2.0 229193000639 probable transmembrane helix predicted by TMHMM2.0 229193000640 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 229193000641 HMMPfam match to entry PF04023 FeoA, E-value 1.3e-18 229193000642 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 229193000643 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 229193000644 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 229193000645 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 229193000646 RNA binding site [nucleotide binding]; other site 229193000647 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 229193000648 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 229193000649 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 229193000650 osmolarity response regulator; Provisional; Region: ompR; PRK09468 229193000651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193000652 active site 229193000653 phosphorylation site [posttranslational modification] 229193000654 intermolecular recognition site; other site 229193000655 dimerization interface [polypeptide binding]; other site 229193000656 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193000657 DNA binding site [nucleotide binding] 229193000658 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 229193000659 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 229193000660 dimerization interface [polypeptide binding]; other site 229193000661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193000662 dimer interface [polypeptide binding]; other site 229193000663 phosphorylation site [posttranslational modification] 229193000664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193000665 ATP binding site [chemical binding]; other site 229193000666 Mg2+ binding site [ion binding]; other site 229193000667 G-X-G motif; other site 229193000668 probable transmembrane helix predicted by TMHMM2.0 229193000669 probable transmembrane helix predicted by TMHMM2.0 229193000670 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 229193000671 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 229193000672 active site 229193000673 substrate-binding site [chemical binding]; other site 229193000674 metal-binding site [ion binding] 229193000675 ATP binding site [chemical binding]; other site 229193000676 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 229193000677 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 229193000678 dimerization interface [polypeptide binding]; other site 229193000679 domain crossover interface; other site 229193000680 redox-dependent activation switch; other site 229193000681 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 229193000682 RNA binding surface [nucleotide binding]; other site 229193000683 BlastProDom match to entry PD021159 sp_P45802_HSLR_ECOLI, E-value 8e-29 229193000684 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 229193000685 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 229193000686 motif I; other site 229193000687 active site 229193000688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193000689 motif II; other site 229193000690 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 229193000691 probable transmembrane helix predicted by TMHMM2.0 229193000692 probable transmembrane helix predicted by TMHMM2.0 229193000693 probable transmembrane helix predicted by TMHMM2.0 229193000694 probable transmembrane helix predicted by TMHMM2.0 229193000695 probable transmembrane helix predicted by TMHMM2.0 229193000696 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 229193000697 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 229193000698 ADP-ribose binding site [chemical binding]; other site 229193000699 dimer interface [polypeptide binding]; other site 229193000700 active site 229193000701 nudix motif; other site 229193000702 metal binding site [ion binding]; metal-binding site 229193000703 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 229193000704 Transglycosylase; Region: Transgly; pfam00912 229193000705 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 229193000706 probable transmembrane helix predicted by TMHMM2.0 229193000707 Competence protein A; Region: Competence_A; pfam11104 229193000708 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 229193000709 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 229193000710 HMMPfam match to entry PF05137 PilN, E-value 0.00011 229193000711 probable transmembrane helix predicted by TMHMM2.0 229193000712 ProfileScan match to entry PS50322 GLN_RICH, E-value 12.349 229193000713 probable transmembrane helix predicted by TMHMM2.0 229193000714 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 229193000715 probable transmembrane helix predicted by TMHMM2.0 229193000716 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 229193000717 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 229193000718 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 229193000719 shikimate kinase; Reviewed; Region: aroK; PRK00131 229193000720 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 229193000721 ADP binding site [chemical binding]; other site 229193000722 magnesium binding site [ion binding]; other site 229193000723 putative shikimate binding site; other site 229193000724 BlastProDom match to entry PD004326 sp_P24167_AROK_ECOLI, E-value 7e-76 229193000725 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 229193000726 active site 229193000727 dimer interface [polypeptide binding]; other site 229193000728 metal binding site [ion binding]; metal-binding site 229193000729 hypothetical protein; Reviewed; Region: PRK11901 229193000730 cell division protein DamX; Validated; Region: PRK10905 229193000731 probable transmembrane helix predicted by TMHMM2.0 229193000732 DNA adenine methylase; Provisional; Region: PRK10904 229193000733 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 229193000734 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 229193000735 substrate binding site [chemical binding]; other site 229193000736 hexamer interface [polypeptide binding]; other site 229193000737 metal binding site [ion binding]; metal-binding site 229193000738 phosphoglycolate phosphatase; Provisional; Region: PRK13222 229193000739 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 229193000740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193000741 motif II; other site 229193000742 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 229193000743 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 229193000744 active site 229193000745 HIGH motif; other site 229193000746 dimer interface [polypeptide binding]; other site 229193000747 KMSKS motif; other site 229193000748 siroheme synthase; Provisional; Region: cysG; PRK10637 229193000749 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 229193000750 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 229193000751 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 229193000752 active site 229193000753 SAM binding site [chemical binding]; other site 229193000754 homodimer interface [polypeptide binding]; other site 229193000755 nitrite transporter NirC; Provisional; Region: PRK11562 229193000756 BlastProDom match to entry PD006963 sp_P11097_NIRC_ECOLI, E-value e-124 229193000757 probable transmembrane helix predicted by TMHMM2.0 229193000758 probable transmembrane helix predicted by TMHMM2.0 229193000759 probable transmembrane helix predicted by TMHMM2.0 229193000760 probable transmembrane helix predicted by TMHMM2.0 229193000761 probable transmembrane helix predicted by TMHMM2.0 229193000762 probable transmembrane helix predicted by TMHMM2.0 229193000763 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 229193000764 nitrite reductase subunit NirD; Provisional; Region: PRK14989 229193000765 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 229193000766 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 229193000767 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 229193000768 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 229193000769 HMMPfam match to entry PF04324 fer2_BFD, E-value 5.7e-25 229193000770 cytosine deaminase; Provisional; Region: PRK09230 229193000771 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 229193000772 active site 229193000773 BlastProDom match to entry PD009908 sp_P25524_CODA_ECOLI, E-value 5e-49 229193000774 putative transporter; Provisional; Region: PRK03699 229193000775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193000776 putative substrate translocation pore; other site 229193000777 probable transmembrane helix predicted by TMHMM2.0 229193000778 probable transmembrane helix predicted by TMHMM2.0 229193000779 probable transmembrane helix predicted by TMHMM2.0 229193000780 probable transmembrane helix predicted by TMHMM2.0 229193000781 probable transmembrane helix predicted by TMHMM2.0 229193000782 probable transmembrane helix predicted by TMHMM2.0 229193000783 probable transmembrane helix predicted by TMHMM2.0 229193000784 probable transmembrane helix predicted by TMHMM2.0 229193000785 probable transmembrane helix predicted by TMHMM2.0 229193000786 probable transmembrane helix predicted by TMHMM2.0 229193000787 probable transmembrane helix predicted by TMHMM2.0 229193000788 probable transmembrane helix predicted by TMHMM2.0 229193000789 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 229193000790 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 229193000791 N-terminal plug; other site 229193000792 ligand-binding site [chemical binding]; other site 229193000793 probable transmembrane helix predicted by TMHMM2.0 229193000794 Transcriptional regulators [Transcription]; Region: PurR; COG1609 229193000795 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193000796 DNA binding site [nucleotide binding] 229193000797 domain linker motif; other site 229193000798 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 229193000799 dimerization interface (closed form) [polypeptide binding]; other site 229193000800 ligand binding site [chemical binding]; other site 229193000801 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 229193000802 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 229193000803 substrate binding site [chemical binding]; other site 229193000804 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 229193000805 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 229193000806 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 229193000807 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 229193000808 glutamine binding [chemical binding]; other site 229193000809 catalytic triad [active] 229193000810 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 229193000811 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 229193000812 inhibitor-cofactor binding pocket; inhibition site 229193000813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193000814 catalytic residue [active] 229193000815 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 229193000816 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 229193000817 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 229193000818 probable transmembrane helix predicted by TMHMM2.0 229193000819 probable transmembrane helix predicted by TMHMM2.0 229193000820 probable transmembrane helix predicted by TMHMM2.0 229193000821 probable transmembrane helix predicted by TMHMM2.0 229193000822 probable transmembrane helix predicted by TMHMM2.0 229193000823 probable transmembrane helix predicted by TMHMM2.0 229193000824 probable transmembrane helix predicted by TMHMM2.0 229193000825 probable transmembrane helix predicted by TMHMM2.0 229193000826 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 229193000827 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 229193000828 ligand binding site [chemical binding]; other site 229193000829 flexible hinge region; other site 229193000830 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 229193000831 putative switch regulator; other site 229193000832 non-specific DNA interactions [nucleotide binding]; other site 229193000833 DNA binding site [nucleotide binding] 229193000834 sequence specific DNA binding site [nucleotide binding]; other site 229193000835 putative cAMP binding site [chemical binding]; other site 229193000836 hypothetical protein; Provisional; Region: PRK10738 229193000837 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 229193000838 probable transmembrane helix predicted by TMHMM2.0 229193000839 probable transmembrane helix predicted by TMHMM2.0 229193000840 probable transmembrane helix predicted by TMHMM2.0 229193000841 phosphoribulokinase; Provisional; Region: PRK15453 229193000842 active site 229193000843 BlastProDom match to entry PD008651 sp_P37307_KPPR_ECOLI, E-value e-140 229193000844 hypothetical protein; Provisional; Region: PRK04966 229193000845 putative hydrolase; Provisional; Region: PRK10985 229193000846 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 229193000847 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 229193000848 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193000849 substrate binding pocket [chemical binding]; other site 229193000850 membrane-bound complex binding site; other site 229193000851 hinge residues; other site 229193000852 HMMPfam match to entry PF04069 OpuAC, E-value 1.8e-15 229193000853 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 229193000854 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 229193000855 Walker A/P-loop; other site 229193000856 ATP binding site [chemical binding]; other site 229193000857 Q-loop/lid; other site 229193000858 ABC transporter signature motif; other site 229193000859 Walker B; other site 229193000860 D-loop; other site 229193000861 H-loop/switch region; other site 229193000862 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 229193000863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193000864 dimer interface [polypeptide binding]; other site 229193000865 conserved gate region; other site 229193000866 putative PBP binding loops; other site 229193000867 ABC-ATPase subunit interface; other site 229193000868 probable transmembrane helix predicted by TMHMM2.0 229193000869 probable transmembrane helix predicted by TMHMM2.0 229193000870 probable transmembrane helix predicted by TMHMM2.0 229193000871 probable transmembrane helix predicted by TMHMM2.0 229193000872 probable transmembrane helix predicted by TMHMM2.0 229193000873 probable transmembrane helix predicted by TMHMM2.0 229193000874 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 229193000875 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 229193000876 active site 229193000877 iron coordination sites [ion binding]; other site 229193000878 substrate binding pocket [chemical binding]; other site 229193000879 putative glycosyl transferase; Provisional; Region: PRK10073 229193000880 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 229193000881 active site 229193000882 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 229193000883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193000884 Walker A/P-loop; other site 229193000885 ATP binding site [chemical binding]; other site 229193000886 Q-loop/lid; other site 229193000887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 229193000888 ABC transporter signature motif; other site 229193000889 Walker B; other site 229193000890 D-loop; other site 229193000891 ABC transporter; Region: ABC_tran_2; pfam12848 229193000892 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 229193000893 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 229193000894 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 229193000895 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 229193000896 TrkA-N domain; Region: TrkA_N; pfam02254 229193000897 probable transmembrane helix predicted by TMHMM2.0 229193000898 probable transmembrane helix predicted by TMHMM2.0 229193000899 probable transmembrane helix predicted by TMHMM2.0 229193000900 probable transmembrane helix predicted by TMHMM2.0 229193000901 probable transmembrane helix predicted by TMHMM2.0 229193000902 probable transmembrane helix predicted by TMHMM2.0 229193000903 probable transmembrane helix predicted by TMHMM2.0 229193000904 probable transmembrane helix predicted by TMHMM2.0 229193000905 probable transmembrane helix predicted by TMHMM2.0 229193000906 probable transmembrane helix predicted by TMHMM2.0 229193000907 probable transmembrane helix predicted by TMHMM2.0 229193000908 probable transmembrane helix predicted by TMHMM2.0 229193000909 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 229193000910 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 229193000911 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 229193000912 ProfileScan match to entry PS50316 HIS_RICH, E-value 13.990 229193000913 probable transmembrane helix predicted by TMHMM2.0 229193000914 phi X174 lysis protein; Provisional; Region: PRK02793 229193000915 HMMPfam match to entry PF04102 SlyX, E-value 1.6e-28 229193000916 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 229193000917 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 229193000918 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 229193000919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 229193000920 YheO-like PAS domain; Region: PAS_6; pfam08348 229193000921 HTH domain; Region: HTH_22; pfam13309 229193000922 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 229193000923 sulfur relay protein TusC; Validated; Region: PRK00211 229193000924 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 229193000925 HMMPfam match to entry PF04077 DsrH, E-value 4.5e-22 229193000926 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 229193000927 S17 interaction site [polypeptide binding]; other site 229193000928 S8 interaction site; other site 229193000929 16S rRNA interaction site [nucleotide binding]; other site 229193000930 streptomycin interaction site [chemical binding]; other site 229193000931 23S rRNA interaction site [nucleotide binding]; other site 229193000932 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 229193000933 30S ribosomal protein S7; Validated; Region: PRK05302 229193000934 elongation factor G; Reviewed; Region: PRK00007 229193000935 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 229193000936 G1 box; other site 229193000937 putative GEF interaction site [polypeptide binding]; other site 229193000938 GTP/Mg2+ binding site [chemical binding]; other site 229193000939 Switch I region; other site 229193000940 G2 box; other site 229193000941 G3 box; other site 229193000942 Switch II region; other site 229193000943 G4 box; other site 229193000944 G5 box; other site 229193000945 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 229193000946 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 229193000947 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 229193000948 elongation factor Tu; Reviewed; Region: PRK00049 229193000949 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 229193000950 G1 box; other site 229193000951 GEF interaction site [polypeptide binding]; other site 229193000952 GTP/Mg2+ binding site [chemical binding]; other site 229193000953 Switch I region; other site 229193000954 G2 box; other site 229193000955 G3 box; other site 229193000956 Switch II region; other site 229193000957 G4 box; other site 229193000958 G5 box; other site 229193000959 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 229193000960 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 229193000961 Antibiotic Binding Site [chemical binding]; other site 229193000962 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193000963 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 229193000964 HMMPfam match to entry PF04324 fer2_BFD, E-value 2.8e-18 229193000965 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 229193000966 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 229193000967 heme binding site [chemical binding]; other site 229193000968 ferroxidase pore; other site 229193000969 ferroxidase diiron center [ion binding]; other site 229193000970 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 229193000971 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 229193000972 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 229193000973 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 229193000974 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 229193000975 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 229193000976 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 229193000977 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 229193000978 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 229193000979 protein-rRNA interface [nucleotide binding]; other site 229193000980 putative translocon binding site; other site 229193000981 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 229193000982 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 229193000983 G-X-X-G motif; other site 229193000984 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 229193000985 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 229193000986 23S rRNA interface [nucleotide binding]; other site 229193000987 5S rRNA interface [nucleotide binding]; other site 229193000988 putative antibiotic binding site [chemical binding]; other site 229193000989 L25 interface [polypeptide binding]; other site 229193000990 L27 interface [polypeptide binding]; other site 229193000991 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 229193000992 23S rRNA interface [nucleotide binding]; other site 229193000993 putative translocon interaction site; other site 229193000994 signal recognition particle (SRP54) interaction site; other site 229193000995 L23 interface [polypeptide binding]; other site 229193000996 trigger factor interaction site; other site 229193000997 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 229193000998 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 229193000999 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 229193001000 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 229193001001 RNA binding site [nucleotide binding]; other site 229193001002 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 229193001003 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 229193001004 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 229193001005 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 229193001006 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 229193001007 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 229193001008 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 229193001009 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 229193001010 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 229193001011 5S rRNA interface [nucleotide binding]; other site 229193001012 23S rRNA interface [nucleotide binding]; other site 229193001013 L5 interface [polypeptide binding]; other site 229193001014 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 229193001015 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 229193001016 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 229193001017 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 229193001018 23S rRNA binding site [nucleotide binding]; other site 229193001019 BlastProDom match to entry PD005137 sp_P46184_RL30_BUCAK, E-value 3e-23 229193001020 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 229193001021 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 229193001022 SecY translocase; Region: SecY; pfam00344 229193001023 probable transmembrane helix predicted by TMHMM2.0 229193001024 probable transmembrane helix predicted by TMHMM2.0 229193001025 probable transmembrane helix predicted by TMHMM2.0 229193001026 probable transmembrane helix predicted by TMHMM2.0 229193001027 probable transmembrane helix predicted by TMHMM2.0 229193001028 probable transmembrane helix predicted by TMHMM2.0 229193001029 probable transmembrane helix predicted by TMHMM2.0 229193001030 probable transmembrane helix predicted by TMHMM2.0 229193001031 probable transmembrane helix predicted by TMHMM2.0 229193001032 probable transmembrane helix predicted by TMHMM2.0 229193001033 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 229193001034 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 229193001035 30S ribosomal protein S13; Region: bact_S13; TIGR03631 229193001036 30S ribosomal protein S11; Validated; Region: PRK05309 229193001037 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 229193001038 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 229193001039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 229193001040 RNA binding surface [nucleotide binding]; other site 229193001041 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 229193001042 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 229193001043 alphaNTD homodimer interface [polypeptide binding]; other site 229193001044 alphaNTD - beta interaction site [polypeptide binding]; other site 229193001045 alphaNTD - beta' interaction site [polypeptide binding]; other site 229193001046 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 229193001047 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 229193001048 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 229193001049 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 229193001050 DNA binding residues [nucleotide binding] 229193001051 dimer interface [polypeptide binding]; other site 229193001052 metal binding site [ion binding]; metal-binding site 229193001053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 229193001054 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 229193001055 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 229193001056 probable transmembrane helix predicted by TMHMM2.0 229193001057 probable transmembrane helix predicted by TMHMM2.0 229193001058 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 229193001059 TrkA-N domain; Region: TrkA_N; pfam02254 229193001060 TrkA-C domain; Region: TrkA_C; pfam02080 229193001061 TrkA-N domain; Region: TrkA_N; pfam02254 229193001062 TrkA-C domain; Region: TrkA_C; pfam02080 229193001063 16S rRNA methyltransferase B; Provisional; Region: PRK10901 229193001064 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 229193001065 putative RNA binding site [nucleotide binding]; other site 229193001066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193001067 S-adenosylmethionine binding site [chemical binding]; other site 229193001068 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 229193001069 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 229193001070 putative active site [active] 229193001071 substrate binding site [chemical binding]; other site 229193001072 putative cosubstrate binding site; other site 229193001073 catalytic site [active] 229193001074 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 229193001075 substrate binding site [chemical binding]; other site 229193001076 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 229193001077 active site 229193001078 catalytic residues [active] 229193001079 metal binding site [ion binding]; metal-binding site 229193001080 hypothetical protein; Provisional; Region: PRK10736 229193001081 DNA protecting protein DprA; Region: dprA; TIGR00732 229193001082 hypothetical protein; Validated; Region: PRK03430 229193001083 HMMPfam match to entry PF04361 DUF494, E-value 1.6e-85 229193001084 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 229193001085 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 229193001086 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 229193001087 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 229193001088 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 229193001089 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 229193001090 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 229193001091 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 229193001092 shikimate binding site; other site 229193001093 NAD(P) binding site [chemical binding]; other site 229193001094 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 229193001095 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 229193001096 trimer interface [polypeptide binding]; other site 229193001097 putative metal binding site [ion binding]; other site 229193001098 rRNA operon 229193001099 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193001100 DNA-binding interface [nucleotide binding]; DNA binding site 229193001101 BlastProDom match to entry PD002176 sp_Q981E7_Q981E7_RHILO, E-value 8e-14 229193001102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 229193001103 HTH-like domain; Region: HTH_21; pfam13276 229193001104 Integrase core domain; Region: rve; pfam00665 229193001105 Integrase core domain; Region: rve_3; pfam13683 229193001106 transposase/IS protein; Provisional; Region: PRK09183 229193001107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193001108 Walker A motif; other site 229193001109 ATP binding site [chemical binding]; other site 229193001110 Walker B motif; other site 229193001111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193001112 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193001113 DNA-binding interface [nucleotide binding]; DNA binding site 229193001114 Integrase core domain; Region: rve; pfam00665 229193001115 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193001116 DNA gyrase inhibitor; Reviewed; Region: PRK00418 229193001117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 229193001118 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 229193001119 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 229193001120 CoA-binding site [chemical binding]; other site 229193001121 ATP-binding [chemical binding]; other site 229193001122 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 229193001123 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 229193001124 active site 229193001125 type IV pilin biogenesis protein; Provisional; Region: PRK10573 229193001126 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 229193001127 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 229193001128 probable transmembrane helix predicted by TMHMM2.0 229193001129 probable transmembrane helix predicted by TMHMM2.0 229193001130 probable transmembrane helix predicted by TMHMM2.0 229193001131 hypothetical protein; Provisional; Region: PRK10436 229193001132 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 229193001133 Walker A motif; other site 229193001134 ATP binding site [chemical binding]; other site 229193001135 Walker B motif; other site 229193001136 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 229193001137 putative major pilin subunit; Provisional; Region: PRK10574 229193001138 probable transmembrane helix predicted by TMHMM2.0 229193001139 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 229193001140 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 229193001141 dimerization interface [polypeptide binding]; other site 229193001142 active site 229193001143 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 229193001144 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 229193001145 amidase catalytic site [active] 229193001146 Zn binding residues [ion binding]; other site 229193001147 substrate binding site [chemical binding]; other site 229193001148 regulatory protein AmpE; Provisional; Region: PRK10987 229193001149 probable transmembrane helix predicted by TMHMM2.0 229193001150 probable transmembrane helix predicted by TMHMM2.0 229193001151 probable transmembrane helix predicted by TMHMM2.0 229193001152 probable transmembrane helix predicted by TMHMM2.0 229193001153 aromatic amino acid transporter; Provisional; Region: PRK10238 229193001154 probable transmembrane helix predicted by TMHMM2.0 229193001155 probable transmembrane helix predicted by TMHMM2.0 229193001156 probable transmembrane helix predicted by TMHMM2.0 229193001157 probable transmembrane helix predicted by TMHMM2.0 229193001158 probable transmembrane helix predicted by TMHMM2.0 229193001159 probable transmembrane helix predicted by TMHMM2.0 229193001160 probable transmembrane helix predicted by TMHMM2.0 229193001161 probable transmembrane helix predicted by TMHMM2.0 229193001162 probable transmembrane helix predicted by TMHMM2.0 229193001163 probable transmembrane helix predicted by TMHMM2.0 229193001164 probable transmembrane helix predicted by TMHMM2.0 229193001165 probable transmembrane helix predicted by TMHMM2.0 229193001166 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 229193001167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 229193001168 DNA-binding site [nucleotide binding]; DNA binding site 229193001169 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 229193001170 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 229193001171 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 229193001172 dimer interface [polypeptide binding]; other site 229193001173 TPP-binding site [chemical binding]; other site 229193001174 ProfileScan match to entry PS50310 ALA_RICH, E-value 9.005 229193001175 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 229193001176 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 229193001177 E3 interaction surface; other site 229193001178 lipoyl attachment site [posttranslational modification]; other site 229193001179 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 229193001180 E3 interaction surface; other site 229193001181 lipoyl attachment site [posttranslational modification]; other site 229193001182 e3 binding domain; Region: E3_binding; pfam02817 229193001183 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 229193001184 ProfileScan match to entry PS50310 ALA_RICH, E-value 9.005 229193001185 probable transmembrane helix predicted by TMHMM2.0 229193001186 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 229193001187 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 229193001188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 229193001189 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 229193001190 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193001191 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 229193001192 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 229193001193 substrate binding site [chemical binding]; other site 229193001194 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 229193001195 substrate binding site [chemical binding]; other site 229193001196 ligand binding site [chemical binding]; other site 229193001197 hypothetical protein; Provisional; Region: PRK05248 229193001198 aromatic amino acid exporter; Provisional; Region: PRK11689 229193001199 EamA-like transporter family; Region: EamA; cl17759 229193001200 probable transmembrane helix predicted by TMHMM2.0 229193001201 probable transmembrane helix predicted by TMHMM2.0 229193001202 probable transmembrane helix predicted by TMHMM2.0 229193001203 probable transmembrane helix predicted by TMHMM2.0 229193001204 probable transmembrane helix predicted by TMHMM2.0 229193001205 probable transmembrane helix predicted by TMHMM2.0 229193001206 probable transmembrane helix predicted by TMHMM2.0 229193001207 probable transmembrane helix predicted by TMHMM2.0 229193001208 probable transmembrane helix predicted by TMHMM2.0 229193001209 probable transmembrane helix predicted by TMHMM2.0 229193001210 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 229193001211 spermidine synthase; Provisional; Region: PRK00811 229193001212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193001213 S-adenosylmethionine binding site [chemical binding]; other site 229193001214 BlastProDom match to entry PD002785 sp_P09158_SPEE_ECOLI, E-value 6e-99 229193001215 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 229193001216 multicopper oxidase; Provisional; Region: PRK10965 229193001217 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 229193001218 Multicopper oxidase; Region: Cu-oxidase; pfam00394 229193001219 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 229193001220 ProfileScan match to entry PS50320 MET_RICH, E-value 10.015 229193001221 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 229193001222 active site 229193001223 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 229193001224 active site clefts [active] 229193001225 zinc binding site [ion binding]; other site 229193001226 dimer interface [polypeptide binding]; other site 229193001227 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 229193001228 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 229193001229 Walker A/P-loop; other site 229193001230 ATP binding site [chemical binding]; other site 229193001231 Q-loop/lid; other site 229193001232 ABC transporter signature motif; other site 229193001233 Walker B; other site 229193001234 D-loop; other site 229193001235 H-loop/switch region; other site 229193001236 inner membrane transport permease; Provisional; Region: PRK15066 229193001237 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 229193001238 probable transmembrane helix predicted by TMHMM2.0 229193001239 probable transmembrane helix predicted by TMHMM2.0 229193001240 probable transmembrane helix predicted by TMHMM2.0 229193001241 probable transmembrane helix predicted by TMHMM2.0 229193001242 probable transmembrane helix predicted by TMHMM2.0 229193001243 probable transmembrane helix predicted by TMHMM2.0 229193001244 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 229193001245 tetramerization interface [polypeptide binding]; other site 229193001246 active site 229193001247 pantoate--beta-alanine ligase; Region: panC; TIGR00018 229193001248 Pantoate-beta-alanine ligase; Region: PanC; cd00560 229193001249 active site 229193001250 ATP-binding site [chemical binding]; other site 229193001251 pantoate-binding site; other site 229193001252 HXXH motif; other site 229193001253 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 229193001254 oligomerization interface [polypeptide binding]; other site 229193001255 active site 229193001256 metal binding site [ion binding]; metal-binding site 229193001257 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 229193001258 catalytic center binding site [active] 229193001259 ATP binding site [chemical binding]; other site 229193001260 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 229193001261 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 229193001262 active site 229193001263 NTP binding site [chemical binding]; other site 229193001264 metal binding triad [ion binding]; metal-binding site 229193001265 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 229193001266 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 229193001267 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 229193001268 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 229193001269 active site 229193001270 nucleotide binding site [chemical binding]; other site 229193001271 HIGH motif; other site 229193001272 KMSKS motif; other site 229193001273 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 229193001274 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 229193001275 2'-5' RNA ligase; Provisional; Region: PRK15124 229193001276 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 229193001277 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 229193001278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 229193001279 ATP binding site [chemical binding]; other site 229193001280 putative Mg++ binding site [ion binding]; other site 229193001281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193001282 nucleotide binding region [chemical binding]; other site 229193001283 ATP-binding site [chemical binding]; other site 229193001284 Helicase associated domain (HA2); Region: HA2; pfam04408 229193001285 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 229193001286 HMMPfam match to entry PF04408 HA2, E-value 2.5e-07 229193001287 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 229193001288 Transglycosylase; Region: Transgly; pfam00912 229193001289 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 229193001290 probable transmembrane helix predicted by TMHMM2.0 229193001291 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 229193001292 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 229193001293 Walker A/P-loop; other site 229193001294 ATP binding site [chemical binding]; other site 229193001295 Q-loop/lid; other site 229193001296 ABC transporter signature motif; other site 229193001297 Walker B; other site 229193001298 D-loop; other site 229193001299 H-loop/switch region; other site 229193001300 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 229193001301 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 229193001302 siderophore binding site; other site 229193001303 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 229193001304 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193001305 ABC-ATPase subunit interface; other site 229193001306 dimer interface [polypeptide binding]; other site 229193001307 putative PBP binding regions; other site 229193001308 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193001309 ABC-ATPase subunit interface; other site 229193001310 dimer interface [polypeptide binding]; other site 229193001311 putative PBP binding regions; other site 229193001312 probable transmembrane helix predicted by TMHMM2.0 229193001313 ProfileScan match to entry PS50319 LEU_RICH, E-value 12.479 229193001314 probable transmembrane helix predicted by TMHMM2.0 229193001315 probable transmembrane helix predicted by TMHMM2.0 229193001316 probable transmembrane helix predicted by TMHMM2.0 229193001317 probable transmembrane helix predicted by TMHMM2.0 229193001318 probable transmembrane helix predicted by TMHMM2.0 229193001319 probable transmembrane helix predicted by TMHMM2.0 229193001320 probable transmembrane helix predicted by TMHMM2.0 229193001321 probable transmembrane helix predicted by TMHMM2.0 229193001322 probable transmembrane helix predicted by TMHMM2.0 229193001323 probable transmembrane helix predicted by TMHMM2.0 229193001324 probable transmembrane helix predicted by TMHMM2.0 229193001325 probable transmembrane helix predicted by TMHMM2.0 229193001326 probable transmembrane helix predicted by TMHMM2.0 229193001327 probable transmembrane helix predicted by TMHMM2.0 229193001328 probable transmembrane helix predicted by TMHMM2.0 229193001329 probable transmembrane helix predicted by TMHMM2.0 229193001330 probable transmembrane helix predicted by TMHMM2.0 229193001331 probable transmembrane helix predicted by TMHMM2.0 229193001332 probable transmembrane helix predicted by TMHMM2.0 229193001333 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 229193001334 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 229193001335 inhibitor-cofactor binding pocket; inhibition site 229193001336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193001337 catalytic residue [active] 229193001338 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 229193001339 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 229193001340 Cl- selectivity filter; other site 229193001341 Cl- binding residues [ion binding]; other site 229193001342 pore gating glutamate residue; other site 229193001343 dimer interface [polypeptide binding]; other site 229193001344 H+/Cl- coupling transport residue; other site 229193001345 probable transmembrane helix predicted by TMHMM2.0 229193001346 probable transmembrane helix predicted by TMHMM2.0 229193001347 probable transmembrane helix predicted by TMHMM2.0 229193001348 probable transmembrane helix predicted by TMHMM2.0 229193001349 probable transmembrane helix predicted by TMHMM2.0 229193001350 probable transmembrane helix predicted by TMHMM2.0 229193001351 probable transmembrane helix predicted by TMHMM2.0 229193001352 probable transmembrane helix predicted by TMHMM2.0 229193001353 probable transmembrane helix predicted by TMHMM2.0 229193001354 probable transmembrane helix predicted by TMHMM2.0 229193001355 probable transmembrane helix predicted by TMHMM2.0 229193001356 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 229193001357 hypothetical protein; Provisional; Region: PRK10578 229193001358 UPF0126 domain; Region: UPF0126; pfam03458 229193001359 UPF0126 domain; Region: UPF0126; pfam03458 229193001360 probable transmembrane helix predicted by TMHMM2.0 229193001361 probable transmembrane helix predicted by TMHMM2.0 229193001362 probable transmembrane helix predicted by TMHMM2.0 229193001363 probable transmembrane helix predicted by TMHMM2.0 229193001364 probable transmembrane helix predicted by TMHMM2.0 229193001365 probable transmembrane helix predicted by TMHMM2.0 229193001366 probable transmembrane helix predicted by TMHMM2.0 229193001367 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 229193001368 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 229193001369 cobalamin binding residues [chemical binding]; other site 229193001370 putative BtuC binding residues; other site 229193001371 dimer interface [polypeptide binding]; other site 229193001372 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 229193001373 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 229193001374 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 229193001375 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 229193001376 Zn2+ binding site [ion binding]; other site 229193001377 Mg2+ binding site [ion binding]; other site 229193001378 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 229193001379 serine endoprotease; Provisional; Region: PRK10942 229193001380 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 229193001381 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 229193001382 protein binding site [polypeptide binding]; other site 229193001383 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 229193001384 probable transmembrane helix predicted by TMHMM2.0 229193001385 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 229193001386 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 229193001387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 229193001388 dimerization interface [polypeptide binding]; other site 229193001389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193001390 dimer interface [polypeptide binding]; other site 229193001391 phosphorylation site [posttranslational modification] 229193001392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193001393 ATP binding site [chemical binding]; other site 229193001394 Mg2+ binding site [ion binding]; other site 229193001395 G-X-G motif; other site 229193001396 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 229193001397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193001398 active site 229193001399 phosphorylation site [posttranslational modification] 229193001400 intermolecular recognition site; other site 229193001401 dimerization interface [polypeptide binding]; other site 229193001402 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 229193001403 putative binding surface; other site 229193001404 active site 229193001405 probable transmembrane helix predicted by TMHMM2.0 229193001406 probable transmembrane helix predicted by TMHMM2.0 229193001407 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 229193001408 HD domain; Region: HD_4; pfam13328 229193001409 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 229193001410 synthetase active site [active] 229193001411 NTP binding site [chemical binding]; other site 229193001412 metal binding site [ion binding]; metal-binding site 229193001413 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 229193001414 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 229193001415 HMMPfam match to entry PF04607 RelA_SpoT, E-value 1.2e-70 229193001416 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 229193001417 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 229193001418 homodimer interface [polypeptide binding]; other site 229193001419 metal binding site [ion binding]; metal-binding site 229193001420 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 229193001421 homodimer interface [polypeptide binding]; other site 229193001422 active site 229193001423 putative chemical substrate binding site [chemical binding]; other site 229193001424 metal binding site [ion binding]; metal-binding site 229193001425 CTP synthetase; Validated; Region: pyrG; PRK05380 229193001426 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 229193001427 Catalytic site [active] 229193001428 active site 229193001429 UTP binding site [chemical binding]; other site 229193001430 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 229193001431 active site 229193001432 putative oxyanion hole; other site 229193001433 catalytic triad [active] 229193001434 probable transmembrane helix predicted by TMHMM2.0 229193001435 enolase; Provisional; Region: eno; PRK00077 229193001436 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 229193001437 dimer interface [polypeptide binding]; other site 229193001438 metal binding site [ion binding]; metal-binding site 229193001439 substrate binding pocket [chemical binding]; other site 229193001440 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 229193001441 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 229193001442 E-class dimer interface [polypeptide binding]; other site 229193001443 P-class dimer interface [polypeptide binding]; other site 229193001444 active site 229193001445 Cu2+ binding site [ion binding]; other site 229193001446 Zn2+ binding site [ion binding]; other site 229193001447 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 229193001448 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 229193001449 HMMPfam match to entry PF04055 Radical_SAM, E-value 0.025 229193001450 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 229193001451 active site 229193001452 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 229193001453 Flavodoxin; Region: Flavodoxin_1; pfam00258 229193001454 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 229193001455 FAD binding pocket [chemical binding]; other site 229193001456 FAD binding motif [chemical binding]; other site 229193001457 catalytic residues [active] 229193001458 NAD binding pocket [chemical binding]; other site 229193001459 phosphate binding motif [ion binding]; other site 229193001460 beta-alpha-beta structure motif; other site 229193001461 sulfite reductase subunit beta; Provisional; Region: PRK13504 229193001462 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 229193001463 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 229193001464 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 229193001465 YcfA-like protein; Region: YcfA; pfam07927 229193001466 probable transmembrane helix predicted by TMHMM2.0 229193001467 Contains Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase (Interpro|IPR000878, (GO:0008152), (GO:0008168)) . Contains Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase (Interpro|IPR000878, (GO:0008152), (GO:0008168)). Contains Uroporphiryn-III C-methyltransferase (Interpro|IPR003043, (GO:0006779), (GO:0008168)). Contains Uroporphyrin-III C-methyltransferase, C-terminal (Interpro|IPR006366). Contains Siroheme synthase, N-terminal (Interpro|IPR006367). Contains Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase (Interpro|IPR000878, (GO:0008152), (GO:0008168)). Contains Uroporphiryn-III C-methyltransferase (Interpro|IPR003043) 229193001468 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 229193001469 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 229193001470 Active Sites [active] 229193001471 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 229193001472 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 229193001473 CysD dimerization site [polypeptide binding]; other site 229193001474 G1 box; other site 229193001475 putative GEF interaction site [polypeptide binding]; other site 229193001476 GTP/Mg2+ binding site [chemical binding]; other site 229193001477 Switch I region; other site 229193001478 G2 box; other site 229193001479 G3 box; other site 229193001480 Switch II region; other site 229193001481 G4 box; other site 229193001482 G5 box; other site 229193001483 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 229193001484 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 229193001485 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 229193001486 ligand-binding site [chemical binding]; other site 229193001487 hypothetical protein; Provisional; Region: PRK10726 229193001488 probable transmembrane helix predicted by TMHMM2.0 229193001489 probable transmembrane helix predicted by TMHMM2.0 229193001490 probable transmembrane helix predicted by TMHMM2.0 229193001491 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 229193001492 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 229193001493 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 229193001494 substrate binding site; other site 229193001495 dimer interface; other site 229193001496 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 229193001497 homotrimer interaction site [polypeptide binding]; other site 229193001498 zinc binding site [ion binding]; other site 229193001499 CDP-binding sites; other site 229193001500 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 229193001501 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 229193001502 Permutation of conserved domain; other site 229193001503 active site 229193001504 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 229193001505 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 229193001506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193001507 S-adenosylmethionine binding site [chemical binding]; other site 229193001508 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 229193001509 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 229193001510 Peptidase family M23; Region: Peptidase_M23; pfam01551 229193001511 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 229193001512 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 229193001513 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 229193001514 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 229193001515 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 229193001516 DNA binding residues [nucleotide binding] 229193001517 HMMPfam match to entry PF04542 sigma70_r2, E-value 4.8e-26 229193001518 HMMPfam match to entry PF04539 sigma70_r3, E-value 1.4e-26 229193001519 HMMPfam match to entry PF04545 sigma70_r4, E-value 2.3e-17 229193001520 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 229193001521 MutS domain I; Region: MutS_I; pfam01624 229193001522 MutS domain II; Region: MutS_II; pfam05188 229193001523 MutS domain III; Region: MutS_III; pfam05192 229193001524 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 229193001525 Walker A/P-loop; other site 229193001526 ATP binding site [chemical binding]; other site 229193001527 Q-loop/lid; other site 229193001528 ABC transporter signature motif; other site 229193001529 Walker B; other site 229193001530 D-loop; other site 229193001531 H-loop/switch region; other site 229193001532 HMMPfam match to entry PF05192 MutS_III, E-value 2.1e-80 229193001533 HMMPfam match to entry PF05190 MutS_IV, E-value 1.4e-40 229193001534 HMMPfam match to entry PF05188 MutS_II, E-value 4.6e-48 229193001535 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 229193001536 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 229193001537 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 229193001538 putative NAD(P) binding site [chemical binding]; other site 229193001539 catalytic Zn binding site [ion binding]; other site 229193001540 structural Zn binding site [ion binding]; other site 229193001541 short chain dehydrogenase; Provisional; Region: PRK06841 229193001542 classical (c) SDRs; Region: SDR_c; cd05233 229193001543 NAD(P) binding site [chemical binding]; other site 229193001544 active site 229193001545 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 229193001546 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 229193001547 DAK2 domain; Region: Dak2; pfam02734 229193001548 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 229193001549 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 229193001550 DNA binding residues [nucleotide binding] 229193001551 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 229193001552 HMMPfam match to entry PF04198 Sugar-bind, E-value 9.8e-101 229193001553 arsenical pump membrane protein; Provisional; Region: PRK15445 229193001554 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 229193001555 transmembrane helices; other site 229193001556 probable transmembrane helix predicted by TMHMM2.0 229193001557 probable transmembrane helix predicted by TMHMM2.0 229193001558 probable transmembrane helix predicted by TMHMM2.0 229193001559 probable transmembrane helix predicted by TMHMM2.0 229193001560 probable transmembrane helix predicted by TMHMM2.0 229193001561 probable transmembrane helix predicted by TMHMM2.0 229193001562 probable transmembrane helix predicted by TMHMM2.0 229193001563 probable transmembrane helix predicted by TMHMM2.0 229193001564 probable transmembrane helix predicted by TMHMM2.0 229193001565 probable transmembrane helix predicted by TMHMM2.0 229193001566 probable transmembrane helix predicted by TMHMM2.0 229193001567 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 229193001568 dimerization interface [polypeptide binding]; other site 229193001569 putative DNA binding site [nucleotide binding]; other site 229193001570 putative Zn2+ binding site [ion binding]; other site 229193001571 FaeA-like protein; Region: FaeA; pfam04703 229193001572 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 229193001573 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193001574 substrate binding pocket [chemical binding]; other site 229193001575 membrane-bound complex binding site; other site 229193001576 hinge residues; other site 229193001577 Haem-binding domain; Region: Haem_bd; pfam14376 229193001578 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 229193001579 probable transmembrane helix predicted by TMHMM2.0 229193001580 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 229193001581 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 229193001582 N-terminal plug; other site 229193001583 ligand-binding site [chemical binding]; other site 229193001584 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 229193001585 Yersinia protein of unknown function (DUF3831); Region: DUF3831; pfam12908 229193001586 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 229193001587 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 229193001588 active site 229193001589 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 229193001590 fumarate hydratase; Provisional; Region: PRK15389 229193001591 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 229193001592 Fumarase C-terminus; Region: Fumerase_C; pfam05683 229193001593 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 229193001594 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 229193001595 putative N- and C-terminal domain interface [polypeptide binding]; other site 229193001596 putative active site [active] 229193001597 MgATP binding site [chemical binding]; other site 229193001598 catalytic site [active] 229193001599 metal binding site [ion binding]; metal-binding site 229193001600 putative xylulose binding site [chemical binding]; other site 229193001601 Putative L-xylulose-5-phosphate 3-epimerase [Carbohydrate transport and metabolism]; Region: SgaU; COG3623 229193001602 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 229193001603 AP (apurinic/apyrimidinic) site pocket; other site 229193001604 DNA interaction; other site 229193001605 Metal-binding active site; metal-binding site 229193001606 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193001607 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193001608 TM-ABC transporter signature motif; other site 229193001609 probable transmembrane helix predicted by TMHMM2.0 229193001610 probable transmembrane helix predicted by TMHMM2.0 229193001611 probable transmembrane helix predicted by TMHMM2.0 229193001612 probable transmembrane helix predicted by TMHMM2.0 229193001613 probable transmembrane helix predicted by TMHMM2.0 229193001614 probable transmembrane helix predicted by TMHMM2.0 229193001615 probable transmembrane helix predicted by TMHMM2.0 229193001616 probable transmembrane helix predicted by TMHMM2.0 229193001617 probable transmembrane helix predicted by TMHMM2.0 229193001618 probable transmembrane helix predicted by TMHMM2.0 229193001619 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193001620 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193001621 TM-ABC transporter signature motif; other site 229193001622 probable transmembrane helix predicted by TMHMM2.0 229193001623 probable transmembrane helix predicted by TMHMM2.0 229193001624 probable transmembrane helix predicted by TMHMM2.0 229193001625 probable transmembrane helix predicted by TMHMM2.0 229193001626 probable transmembrane helix predicted by TMHMM2.0 229193001627 probable transmembrane helix predicted by TMHMM2.0 229193001628 probable transmembrane helix predicted by TMHMM2.0 229193001629 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 229193001630 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193001631 Walker A/P-loop; other site 229193001632 ATP binding site [chemical binding]; other site 229193001633 Q-loop/lid; other site 229193001634 ABC transporter signature motif; other site 229193001635 Walker B; other site 229193001636 D-loop; other site 229193001637 H-loop/switch region; other site 229193001638 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193001639 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 229193001640 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 229193001641 ligand binding site [chemical binding]; other site 229193001642 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 229193001643 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 229193001644 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 229193001645 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK13213 229193001646 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 229193001647 intersubunit interface [polypeptide binding]; other site 229193001648 active site 229193001649 Zn2+ binding site [ion binding]; other site 229193001650 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 229193001651 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 229193001652 putative [Fe4-S4] binding site [ion binding]; other site 229193001653 putative molybdopterin cofactor binding site [chemical binding]; other site 229193001654 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 229193001655 putative molybdopterin cofactor binding site; other site 229193001656 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 229193001657 4Fe-4S binding domain; Region: Fer4; cl02805 229193001658 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 229193001659 probable transmembrane helix predicted by TMHMM2.0 229193001660 probable transmembrane helix predicted by TMHMM2.0 229193001661 probable transmembrane helix predicted by TMHMM2.0 229193001662 probable transmembrane helix predicted by TMHMM2.0 229193001663 probable transmembrane helix predicted by TMHMM2.0 229193001664 probable transmembrane helix predicted by TMHMM2.0 229193001665 probable transmembrane helix predicted by TMHMM2.0 229193001666 probable transmembrane helix predicted by TMHMM2.0 229193001667 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 229193001668 cytochrome b561; Provisional; Region: PRK11513 229193001669 probable transmembrane helix predicted by TMHMM2.0 229193001670 probable transmembrane helix predicted by TMHMM2.0 229193001671 probable transmembrane helix predicted by TMHMM2.0 229193001672 probable transmembrane helix predicted by TMHMM2.0 229193001673 Soluble cytochrome b562 [Energy production and conversion]; Region: CybC; COG3783 229193001674 probable transmembrane helix predicted by TMHMM2.0 229193001675 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 229193001676 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 229193001677 dimer interface [polypeptide binding]; other site 229193001678 active site 229193001679 heme binding site [chemical binding]; other site 229193001680 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 229193001681 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 229193001682 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 229193001683 ligand binding site [chemical binding]; other site 229193001684 dimerization interface [polypeptide binding]; other site 229193001685 probable transmembrane helix predicted by TMHMM2.0 229193001686 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618 229193001687 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 229193001688 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193001689 Walker A/P-loop; other site 229193001690 ATP binding site [chemical binding]; other site 229193001691 Q-loop/lid; other site 229193001692 ABC transporter signature motif; other site 229193001693 Walker B; other site 229193001694 D-loop; other site 229193001695 H-loop/switch region; other site 229193001696 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193001697 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193001698 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193001699 TM-ABC transporter signature motif; other site 229193001700 probable transmembrane helix predicted by TMHMM2.0 229193001701 probable transmembrane helix predicted by TMHMM2.0 229193001702 probable transmembrane helix predicted by TMHMM2.0 229193001703 probable transmembrane helix predicted by TMHMM2.0 229193001704 probable transmembrane helix predicted by TMHMM2.0 229193001705 probable transmembrane helix predicted by TMHMM2.0 229193001706 probable transmembrane helix predicted by TMHMM2.0 229193001707 probable transmembrane helix predicted by TMHMM2.0 229193001708 probable transmembrane helix predicted by TMHMM2.0 229193001709 probable transmembrane helix predicted by TMHMM2.0 229193001710 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 229193001711 TPP-binding site [chemical binding]; other site 229193001712 dimer interface [polypeptide binding]; other site 229193001713 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 229193001714 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 229193001715 PYR/PP interface [polypeptide binding]; other site 229193001716 dimer interface [polypeptide binding]; other site 229193001717 TPP binding site [chemical binding]; other site 229193001718 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 229193001719 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 229193001720 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 229193001721 N- and C-terminal domain interface [polypeptide binding]; other site 229193001722 active site 229193001723 MgATP binding site [chemical binding]; other site 229193001724 catalytic site [active] 229193001725 metal binding site [ion binding]; metal-binding site 229193001726 putative homotetramer interface [polypeptide binding]; other site 229193001727 putative homodimer interface [polypeptide binding]; other site 229193001728 glycerol binding site [chemical binding]; other site 229193001729 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 229193001730 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 229193001731 hexamer (dimer of trimers) interface [polypeptide binding]; other site 229193001732 substrate binding site [chemical binding]; other site 229193001733 trimer interface [polypeptide binding]; other site 229193001734 Mn binding site [ion binding]; other site 229193001735 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 229193001736 MarR family; Region: MarR_2; cl17246 229193001737 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 229193001738 HMMPfam match to entry PF04198 Sugar-bind, E-value 6.9e-61 229193001739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193001740 putative MFS family transporter protein; Provisional; Region: PRK03633 229193001741 putative substrate translocation pore; other site 229193001742 probable transmembrane helix predicted by TMHMM2.0 229193001743 probable transmembrane helix predicted by TMHMM2.0 229193001744 probable transmembrane helix predicted by TMHMM2.0 229193001745 probable transmembrane helix predicted by TMHMM2.0 229193001746 probable transmembrane helix predicted by TMHMM2.0 229193001747 probable transmembrane helix predicted by TMHMM2.0 229193001748 probable transmembrane helix predicted by TMHMM2.0 229193001749 probable transmembrane helix predicted by TMHMM2.0 229193001750 probable transmembrane helix predicted by TMHMM2.0 229193001751 probable transmembrane helix predicted by TMHMM2.0 229193001752 probable transmembrane helix predicted by TMHMM2.0 229193001753 probable transmembrane helix predicted by TMHMM2.0 229193001754 hypothetical protein; Validated; Region: PRK03661 229193001755 recombinase A; Provisional; Region: recA; PRK09354 229193001756 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 229193001757 hexamer interface [polypeptide binding]; other site 229193001758 Walker A motif; other site 229193001759 ATP binding site [chemical binding]; other site 229193001760 Walker B motif; other site 229193001761 recombination regulator RecX; Reviewed; Region: recX; PRK00117 229193001762 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 229193001763 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 229193001764 motif 1; other site 229193001765 active site 229193001766 motif 2; other site 229193001767 motif 3; other site 229193001768 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 229193001769 DHHA1 domain; Region: DHHA1; pfam02272 229193001770 carbon storage regulator; Provisional; Region: PRK01712 229193001771 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 229193001772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193001773 motif II; other site 229193001774 Predicted membrane protein [Function unknown]; Region: COG1238 229193001775 probable transmembrane helix predicted by TMHMM2.0 229193001776 probable transmembrane helix predicted by TMHMM2.0 229193001777 probable transmembrane helix predicted by TMHMM2.0 229193001778 probable transmembrane helix predicted by TMHMM2.0 229193001779 glutamate--cysteine ligase; Provisional; Region: PRK02107 229193001780 HMMPfam match to entry PF04262 glu_cys_ligase, E-value 1.4e-263 229193001781 S-ribosylhomocysteinase; Provisional; Region: PRK02260 229193001782 hypothetical protein; Provisional; Region: PRK11573 229193001783 Domain of unknown function DUF21; Region: DUF21; pfam01595 229193001784 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 229193001785 Transporter associated domain; Region: CorC_HlyC; smart01091 229193001786 probable transmembrane helix predicted by TMHMM2.0 229193001787 probable transmembrane helix predicted by TMHMM2.0 229193001788 probable transmembrane helix predicted by TMHMM2.0 229193001789 probable transmembrane helix predicted by TMHMM2.0 229193001790 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 229193001791 probable transmembrane helix predicted by TMHMM2.0 229193001792 probable transmembrane helix predicted by TMHMM2.0 229193001793 probable transmembrane helix predicted by TMHMM2.0 229193001794 probable transmembrane helix predicted by TMHMM2.0 229193001795 probable transmembrane helix predicted by TMHMM2.0 229193001796 probable transmembrane helix predicted by TMHMM2.0 229193001797 probable transmembrane helix predicted by TMHMM2.0 229193001798 probable transmembrane helix predicted by TMHMM2.0 229193001799 signal recognition particle protein; Provisional; Region: PRK10867 229193001800 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 229193001801 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 229193001802 P loop; other site 229193001803 GTP binding site [chemical binding]; other site 229193001804 Signal peptide binding domain; Region: SRP_SPB; pfam02978 229193001805 ProfileScan match to entry PS50320 MET_RICH, E-value 8.861 229193001806 probable transmembrane helix predicted by TMHMM2.0 229193001807 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 229193001808 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 229193001809 RimM N-terminal domain; Region: RimM; pfam01782 229193001810 PRC-barrel domain; Region: PRC; pfam05239 229193001811 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 229193001812 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 229193001813 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 229193001814 HMMPfam match to entry PF04338 DUF481, E-value 1.4e-69 229193001815 Contains Anaerobic c4-dicarboxylate membrane transporter (Interpro|IPR004668, (GO:0016021)) . Contains Anaerobic c4-dicarboxylate membrane transporter (Interpro|IPR004668, (GO:0016021)). Contains Anaerobic c4-dicarboxylate membrane transporter (Interpro|IPR004668, (GO:0016021)) 229193001816 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 229193001817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193001818 active site 229193001819 phosphorylation site [posttranslational modification] 229193001820 intermolecular recognition site; other site 229193001821 dimerization interface [polypeptide binding]; other site 229193001822 LytTr DNA-binding domain; Region: LytTR; pfam04397 229193001823 HMMPfam match to entry PF04397 LytTR, E-value 1.1e-22 229193001824 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 229193001825 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 229193001826 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 229193001827 Chorismate mutase type II; Region: CM_2; cl00693 229193001828 prephenate dehydrogenase; Validated; Region: PRK08507 229193001829 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 229193001830 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 229193001831 Prephenate dehydratase; Region: PDT; pfam00800 229193001832 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 229193001833 putative L-Phe binding site [chemical binding]; other site 229193001834 transposase/IS protein; Provisional; Region: PRK09183 229193001835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193001836 Walker A motif; other site 229193001837 ATP binding site [chemical binding]; other site 229193001838 Walker B motif; other site 229193001839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193001840 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193001841 DNA-binding interface [nucleotide binding]; DNA binding site 229193001842 Integrase core domain; Region: rve; pfam00665 229193001843 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 229193001844 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 229193001845 Na binding site [ion binding]; other site 229193001846 probable transmembrane helix predicted by TMHMM2.0 229193001847 probable transmembrane helix predicted by TMHMM2.0 229193001848 probable transmembrane helix predicted by TMHMM2.0 229193001849 probable transmembrane helix predicted by TMHMM2.0 229193001850 probable transmembrane helix predicted by TMHMM2.0 229193001851 probable transmembrane helix predicted by TMHMM2.0 229193001852 probable transmembrane helix predicted by TMHMM2.0 229193001853 probable transmembrane helix predicted by TMHMM2.0 229193001854 probable transmembrane helix predicted by TMHMM2.0 229193001855 probable transmembrane helix predicted by TMHMM2.0 229193001856 probable transmembrane helix predicted by TMHMM2.0 229193001857 probable transmembrane helix predicted by TMHMM2.0 229193001858 probable transmembrane helix predicted by TMHMM2.0 229193001859 probable transmembrane helix predicted by TMHMM2.0 229193001860 Predicted membrane protein [Function unknown]; Region: COG3162 229193001861 HMMPfam match to entry PF04341 DUF485, E-value 5e-51 229193001862 probable transmembrane helix predicted by TMHMM2.0 229193001863 probable transmembrane helix predicted by TMHMM2.0 229193001864 acetyl-CoA synthetase; Provisional; Region: PRK00174 229193001865 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 229193001866 active site 229193001867 CoA binding site [chemical binding]; other site 229193001868 acyl-activating enzyme (AAE) consensus motif; other site 229193001869 AMP binding site [chemical binding]; other site 229193001870 acetate binding site [chemical binding]; other site 229193001871 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 229193001872 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 229193001873 probable transmembrane helix predicted by TMHMM2.0 229193001874 probable transmembrane helix predicted by TMHMM2.0 229193001875 probable transmembrane helix predicted by TMHMM2.0 229193001876 probable transmembrane helix predicted by TMHMM2.0 229193001877 probable transmembrane helix predicted by TMHMM2.0 229193001878 probable transmembrane helix predicted by TMHMM2.0 229193001879 probable transmembrane helix predicted by TMHMM2.0 229193001880 two component system sensor kinase SsrB; Provisional; Region: PRK15369 229193001881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193001882 active site 229193001883 phosphorylation site [posttranslational modification] 229193001884 intermolecular recognition site; other site 229193001885 dimerization interface [polypeptide binding]; other site 229193001886 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193001887 DNA binding residues [nucleotide binding] 229193001888 dimerization interface [polypeptide binding]; other site 229193001889 two component system sensor kinase SsrA; Provisional; Region: PRK15347 229193001890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193001891 dimer interface [polypeptide binding]; other site 229193001892 phosphorylation site [posttranslational modification] 229193001893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193001894 ATP binding site [chemical binding]; other site 229193001895 Mg2+ binding site [ion binding]; other site 229193001896 G-X-G motif; other site 229193001897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193001898 active site 229193001899 phosphorylation site [posttranslational modification] 229193001900 intermolecular recognition site; other site 229193001901 dimerization interface [polypeptide binding]; other site 229193001902 Hpt domain; Region: Hpt; pfam01627 229193001903 probable transmembrane helix predicted by TMHMM2.0 229193001904 probable transmembrane helix predicted by TMHMM2.0 229193001905 probable transmembrane helix predicted by TMHMM2.0 229193001906 outer membrane secretin SsaC; Provisional; Region: PRK15346 229193001907 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 229193001908 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 229193001909 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 229193001910 probable transmembrane helix predicted by TMHMM2.0 229193001911 type III secretion system protein SsaD; Provisional; Region: PRK15367 229193001912 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 229193001913 probable transmembrane helix predicted by TMHMM2.0 229193001914 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 229193001915 Helix-turn-helix domain; Region: HTH_18; pfam12833 229193001916 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193001917 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 229193001918 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 229193001919 Type III secretion needle MxiH like; Region: MxiH; pfam09392 229193001920 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 229193001921 probable transmembrane helix predicted by TMHMM2.0 229193001922 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 229193001923 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 229193001924 type III secretion system protein SsaK; Provisional; Region: PRK15354 229193001925 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 229193001926 FHIPEP family; Region: FHIPEP; pfam00771 229193001927 probable transmembrane helix predicted by TMHMM2.0 229193001928 probable transmembrane helix predicted by TMHMM2.0 229193001929 probable transmembrane helix predicted by TMHMM2.0 229193001930 probable transmembrane helix predicted by TMHMM2.0 229193001931 probable transmembrane helix predicted by TMHMM2.0 229193001932 probable transmembrane helix predicted by TMHMM2.0 229193001933 probable transmembrane helix predicted by TMHMM2.0 229193001934 type III secretion system ATPase; Validated; Region: PRK06820 229193001935 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 229193001936 Walker A motif/ATP binding site; other site 229193001937 Walker B motif; other site 229193001938 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 229193001939 ProfileScan match to entry PS50322 GLN_RICH, E-value 16.458 229193001940 type III secretion system protein SsaQ; Validated; Region: PRK08035 229193001941 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 229193001942 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 229193001943 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 229193001944 probable transmembrane helix predicted by TMHMM2.0 229193001945 probable transmembrane helix predicted by TMHMM2.0 229193001946 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 229193001947 probable transmembrane helix predicted by TMHMM2.0 229193001948 probable transmembrane helix predicted by TMHMM2.0 229193001949 probable transmembrane helix predicted by TMHMM2.0 229193001950 probable transmembrane helix predicted by TMHMM2.0 229193001951 probable transmembrane helix predicted by TMHMM2.0 229193001952 probable transmembrane helix predicted by TMHMM2.0 229193001953 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 229193001954 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 229193001955 probable transmembrane helix predicted by TMHMM2.0 229193001956 probable transmembrane helix predicted by TMHMM2.0 229193001957 probable transmembrane helix predicted by TMHMM2.0 229193001958 probable transmembrane helix predicted by TMHMM2.0 229193001959 putative inner membrane protein; Provisional; Region: PRK11099 229193001960 Sulphur transport; Region: Sulf_transp; pfam04143 229193001961 probable transmembrane helix predicted by TMHMM2.0 229193001962 probable transmembrane helix predicted by TMHMM2.0 229193001963 HMMPfam match to entry PF04143 DUF395, E-value 1.7e-21 229193001964 probable transmembrane helix predicted by TMHMM2.0 229193001965 probable transmembrane helix predicted by TMHMM2.0 229193001966 probable transmembrane helix predicted by TMHMM2.0 229193001967 probable transmembrane helix predicted by TMHMM2.0 229193001968 probable transmembrane helix predicted by TMHMM2.0 229193001969 HMMPfam match to entry PF04143 DUF395, E-value 5e-23 229193001970 probable transmembrane helix predicted by TMHMM2.0 229193001971 probable transmembrane helix predicted by TMHMM2.0 229193001972 probable transmembrane helix predicted by TMHMM2.0 229193001973 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 229193001974 CPxP motif; other site 229193001975 BlastProDom match to entry PD004783 sp_P31065_YEDF_ECOLI, E-value 8e-33 229193001976 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193001977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193001978 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 229193001979 putative effector binding pocket; other site 229193001980 dimerization interface [polypeptide binding]; other site 229193001981 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 229193001982 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 229193001983 probable transmembrane helix predicted by TMHMM2.0 229193001984 BlastProDom match to entry PD008790 sp_P37660_YHJV_ECOLI, E-value e-136 229193001985 probable transmembrane helix predicted by TMHMM2.0 229193001986 probable transmembrane helix predicted by TMHMM2.0 229193001987 probable transmembrane helix predicted by TMHMM2.0 229193001988 probable transmembrane helix predicted by TMHMM2.0 229193001989 probable transmembrane helix predicted by TMHMM2.0 229193001990 probable transmembrane helix predicted by TMHMM2.0 229193001991 probable transmembrane helix predicted by TMHMM2.0 229193001992 probable transmembrane helix predicted by TMHMM2.0 229193001993 probable transmembrane helix predicted by TMHMM2.0 229193001994 probable transmembrane helix predicted by TMHMM2.0 229193001995 probable transmembrane helix predicted by TMHMM2.0 229193001996 cystathionine beta-lyase; Provisional; Region: PRK09028 229193001997 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 229193001998 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193001999 catalytic residue [active] 229193002000 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 229193002001 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 229193002002 Walker A/P-loop; other site 229193002003 ATP binding site [chemical binding]; other site 229193002004 Q-loop/lid; other site 229193002005 ABC transporter signature motif; other site 229193002006 Walker B; other site 229193002007 D-loop; other site 229193002008 H-loop/switch region; other site 229193002009 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 229193002010 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193002011 ABC-ATPase subunit interface; other site 229193002012 dimer interface [polypeptide binding]; other site 229193002013 putative PBP binding regions; other site 229193002014 probable transmembrane helix predicted by TMHMM2.0 229193002015 probable transmembrane helix predicted by TMHMM2.0 229193002016 probable transmembrane helix predicted by TMHMM2.0 229193002017 probable transmembrane helix predicted by TMHMM2.0 229193002018 probable transmembrane helix predicted by TMHMM2.0 229193002019 probable transmembrane helix predicted by TMHMM2.0 229193002020 probable transmembrane helix predicted by TMHMM2.0 229193002021 probable transmembrane helix predicted by TMHMM2.0 229193002022 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 229193002023 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 229193002024 putative hemin binding site; other site 229193002025 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 229193002026 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 229193002027 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 229193002028 HMMPfam match to entry PF05171 HemS, E-value 1.8e-105 229193002029 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 229193002030 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 229193002031 N-terminal plug; other site 229193002032 ligand-binding site [chemical binding]; other site 229193002033 Hemin uptake protein hemP; Region: hemP; pfam10636 229193002034 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 229193002035 NADH(P)-binding; Region: NAD_binding_10; pfam13460 229193002036 NAD(P) binding site [chemical binding]; other site 229193002037 putative active site [active] 229193002038 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 229193002039 highly similar to Yersinia pestis CO92 YPO0286 ( coproporphyrinogen III oxidase) and Yersinia pestis KIM y0547; disrupted by IS100 element 229193002040 transposase/IS protein; Provisional; Region: PRK09183 229193002041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193002042 Walker A motif; other site 229193002043 ATP binding site [chemical binding]; other site 229193002044 Walker B motif; other site 229193002045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193002046 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193002047 DNA-binding interface [nucleotide binding]; DNA binding site 229193002048 Integrase core domain; Region: rve; pfam00665 229193002049 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 229193002050 FAD binding site [chemical binding]; other site 229193002051 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 229193002052 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 229193002053 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 229193002054 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 229193002055 active site 229193002056 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 229193002057 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 229193002058 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 229193002059 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 229193002060 putative metal binding site [ion binding]; other site 229193002061 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 229193002062 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 229193002063 putative metal binding site [ion binding]; other site 229193002064 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 229193002065 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 229193002066 putative metal binding site [ion binding]; other site 229193002067 tellurite resistance protein terB; Region: terB; cd07176 229193002068 putative metal binding site [ion binding]; other site 229193002069 HMMPfam match to entry PF05099 TerB, E-value 9.1e-57 229193002070 Integral membrane protein TerC family; Region: TerC; cl10468 229193002071 probable transmembrane helix predicted by TMHMM2.0 229193002072 probable transmembrane helix predicted by TMHMM2.0 229193002073 probable transmembrane helix predicted by TMHMM2.0 229193002074 probable transmembrane helix predicted by TMHMM2.0 229193002075 probable transmembrane helix predicted by TMHMM2.0 229193002076 probable transmembrane helix predicted by TMHMM2.0 229193002077 probable transmembrane helix predicted by TMHMM2.0 229193002078 probable transmembrane helix predicted by TMHMM2.0 229193002079 probable transmembrane helix predicted by TMHMM2.0 229193002080 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 229193002081 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 229193002082 putative metal binding site [ion binding]; other site 229193002083 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 229193002084 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 229193002085 putative metal binding site [ion binding]; other site 229193002086 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 229193002087 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 229193002088 PapC N-terminal domain; Region: PapC_N; pfam13954 229193002089 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 229193002090 PapC C-terminal domain; Region: PapC_C; pfam13953 229193002091 putative fimbrial chaperone protein; Provisional; Region: PRK09918 229193002092 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193002093 probable transmembrane helix predicted by TMHMM2.0 229193002094 probable transmembrane helix predicted by TMHMM2.0 229193002095 probable transmembrane helix predicted by TMHMM2.0 229193002096 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 229193002097 Berberine and berberine like; Region: BBE; pfam08031 229193002098 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 229193002099 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 229193002100 Interdomain contacts; other site 229193002101 Cytokine receptor motif; other site 229193002102 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 229193002103 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 229193002104 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 229193002105 Autotransporter beta-domain; Region: Autotransporter; smart00869 229193002106 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 229193002107 HMMPfam match to entry PF04345 Chor_lyase, E-value 8.3e-33 229193002108 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 229193002109 UbiA prenyltransferase family; Region: UbiA; pfam01040 229193002110 probable transmembrane helix predicted by TMHMM2.0 229193002111 probable transmembrane helix predicted by TMHMM2.0 229193002112 probable transmembrane helix predicted by TMHMM2.0 229193002113 probable transmembrane helix predicted by TMHMM2.0 229193002114 probable transmembrane helix predicted by TMHMM2.0 229193002115 probable transmembrane helix predicted by TMHMM2.0 229193002116 probable transmembrane helix predicted by TMHMM2.0 229193002117 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 229193002118 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 229193002119 putative acyl-acceptor binding pocket; other site 229193002120 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 229193002121 probable transmembrane helix predicted by TMHMM2.0 229193002122 probable transmembrane helix predicted by TMHMM2.0 229193002123 LexA repressor; Validated; Region: PRK00215 229193002124 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 229193002125 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 229193002126 Catalytic site [active] 229193002127 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 229193002128 metal binding site 2 [ion binding]; metal-binding site 229193002129 putative DNA binding helix; other site 229193002130 metal binding site 1 [ion binding]; metal-binding site 229193002131 dimer interface [polypeptide binding]; other site 229193002132 structural Zn2+ binding site [ion binding]; other site 229193002133 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 229193002134 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 229193002135 FMN binding site [chemical binding]; other site 229193002136 active site 229193002137 catalytic residues [active] 229193002138 substrate binding site [chemical binding]; other site 229193002139 phage shock protein G; Reviewed; Region: pspG; PRK09459 229193002140 probable transmembrane helix predicted by TMHMM2.0 229193002141 probable transmembrane helix predicted by TMHMM2.0 229193002142 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 229193002143 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 229193002144 NADP binding site [chemical binding]; other site 229193002145 dimer interface [polypeptide binding]; other site 229193002146 replicative DNA helicase; Provisional; Region: PRK08006 229193002147 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 229193002148 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 229193002149 Walker A motif; other site 229193002150 ATP binding site [chemical binding]; other site 229193002151 Walker B motif; other site 229193002152 DNA binding loops [nucleotide binding] 229193002153 alanine racemase; Reviewed; Region: alr; PRK00053 229193002154 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 229193002155 active site 229193002156 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 229193002157 substrate binding site [chemical binding]; other site 229193002158 catalytic residues [active] 229193002159 dimer interface [polypeptide binding]; other site 229193002160 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 229193002161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 229193002162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193002163 homodimer interface [polypeptide binding]; other site 229193002164 catalytic residue [active] 229193002165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 229193002166 HMMPfam match to entry PF04237 DUF419, E-value 1.9e-33 229193002167 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 229193002168 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 229193002169 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 229193002170 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 229193002171 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 229193002172 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 229193002173 dimer interface [polypeptide binding]; other site 229193002174 ssDNA binding site [nucleotide binding]; other site 229193002175 tetramer (dimer of dimers) interface [polypeptide binding]; other site 229193002176 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 229193002177 ProfileScan match to entry PS50315 GLY_RICH, E-value 10.141 229193002178 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 229193002179 lactaldehyde reductase; Region: lactal_redase; TIGR02638 229193002180 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 229193002181 dimer interface [polypeptide binding]; other site 229193002182 active site 229193002183 metal binding site [ion binding]; metal-binding site 229193002184 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 229193002185 intersubunit interface [polypeptide binding]; other site 229193002186 active site 229193002187 Zn2+ binding site [ion binding]; other site 229193002188 L-rhamnose isomerase; Provisional; Region: PRK01076 229193002189 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 229193002190 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 229193002191 N- and C-terminal domain interface [polypeptide binding]; other site 229193002192 active site 229193002193 putative catalytic site [active] 229193002194 metal binding site [ion binding]; metal-binding site 229193002195 ATP binding site [chemical binding]; other site 229193002196 rhamnulokinase; Provisional; Region: rhaB; PRK10640 229193002197 carbohydrate binding site [chemical binding]; other site 229193002198 BlastProDom match to entry PD024458 sp_P27030_RHAB_SALTY, E-value 2e-23 229193002199 transcriptional activator RhaS; Provisional; Region: PRK13503 229193002200 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 229193002201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193002202 transcriptional activator RhaR; Provisional; Region: PRK13501 229193002203 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 229193002204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193002205 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 229193002206 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 229193002207 probable transmembrane helix predicted by TMHMM2.0 229193002208 probable transmembrane helix predicted by TMHMM2.0 229193002209 probable transmembrane helix predicted by TMHMM2.0 229193002210 probable transmembrane helix predicted by TMHMM2.0 229193002211 probable transmembrane helix predicted by TMHMM2.0 229193002212 probable transmembrane helix predicted by TMHMM2.0 229193002213 probable transmembrane helix predicted by TMHMM2.0 229193002214 probable transmembrane helix predicted by TMHMM2.0 229193002215 probable transmembrane helix predicted by TMHMM2.0 229193002216 probable transmembrane helix predicted by TMHMM2.0 229193002217 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 229193002218 Viral enhancin protein; Region: Enhancin; pfam03272 229193002219 Peptidase M60-like family; Region: M60-like; pfam13402 229193002220 putative transcriptional regulator; Provisional; Region: PRK11640 229193002221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 229193002222 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 229193002223 4Fe-4S binding domain; Region: Fer4; pfam00037 229193002224 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 229193002225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 229193002226 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 229193002227 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 229193002228 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 229193002229 [4Fe-4S] binding site [ion binding]; other site 229193002230 molybdopterin cofactor binding site; other site 229193002231 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 229193002232 molybdopterin cofactor binding site; other site 229193002233 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 229193002234 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 229193002235 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 229193002236 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 229193002237 DsbD alpha interface [polypeptide binding]; other site 229193002238 catalytic residues [active] 229193002239 probable transmembrane helix predicted by TMHMM2.0 229193002240 probable transmembrane helix predicted by TMHMM2.0 229193002241 probable transmembrane helix predicted by TMHMM2.0 229193002242 probable transmembrane helix predicted by TMHMM2.0 229193002243 probable transmembrane helix predicted by TMHMM2.0 229193002244 probable transmembrane helix predicted by TMHMM2.0 229193002245 probable transmembrane helix predicted by TMHMM2.0 229193002246 probable transmembrane helix predicted by TMHMM2.0 229193002247 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 229193002248 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 229193002249 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 229193002250 probable transmembrane helix predicted by TMHMM2.0 229193002251 probable transmembrane helix predicted by TMHMM2.0 229193002252 probable transmembrane helix predicted by TMHMM2.0 229193002253 probable transmembrane helix predicted by TMHMM2.0 229193002254 probable transmembrane helix predicted by TMHMM2.0 229193002255 probable transmembrane helix predicted by TMHMM2.0 229193002256 probable transmembrane helix predicted by TMHMM2.0 229193002257 probable transmembrane helix predicted by TMHMM2.0 229193002258 probable transmembrane helix predicted by TMHMM2.0 229193002259 probable transmembrane helix predicted by TMHMM2.0 229193002260 probable transmembrane helix predicted by TMHMM2.0 229193002261 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 229193002262 Aspartase; Region: Aspartase; cd01357 229193002263 active sites [active] 229193002264 tetramer interface [polypeptide binding]; other site 229193002265 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 229193002266 HMMPfam match to entry PF04186 FxsA, E-value 4.9e-19 229193002267 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 229193002268 oligomerisation interface [polypeptide binding]; other site 229193002269 mobile loop; other site 229193002270 roof hairpin; other site 229193002271 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 229193002272 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 229193002273 ring oligomerisation interface [polypeptide binding]; other site 229193002274 ATP/Mg binding site [chemical binding]; other site 229193002275 stacking interactions; other site 229193002276 hinge regions; other site 229193002277 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 229193002278 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 229193002279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193002280 FeS/SAM binding site; other site 229193002281 HMMPfam match to entry PF04055 Radical_SAM, E-value 4.1e-10 229193002282 elongation factor P; Validated; Region: PRK00529 229193002283 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 229193002284 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 229193002285 RNA binding site [nucleotide binding]; other site 229193002286 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 229193002287 RNA binding site [nucleotide binding]; other site 229193002288 multidrug efflux system protein; Provisional; Region: PRK11431 229193002289 probable transmembrane helix predicted by TMHMM2.0 229193002290 probable transmembrane helix predicted by TMHMM2.0 229193002291 probable transmembrane helix predicted by TMHMM2.0 229193002292 probable transmembrane helix predicted by TMHMM2.0 229193002293 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 229193002294 Iron-sulfur protein interface; other site 229193002295 proximal quinone binding site [chemical binding]; other site 229193002296 C-subunit interface; other site 229193002297 distal quinone binding site; other site 229193002298 probable transmembrane helix predicted by TMHMM2.0 229193002299 probable transmembrane helix predicted by TMHMM2.0 229193002300 probable transmembrane helix predicted by TMHMM2.0 229193002301 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 229193002302 D-subunit interface [polypeptide binding]; other site 229193002303 Iron-sulfur protein interface; other site 229193002304 proximal quinone binding site [chemical binding]; other site 229193002305 probable transmembrane helix predicted by TMHMM2.0 229193002306 probable transmembrane helix predicted by TMHMM2.0 229193002307 probable transmembrane helix predicted by TMHMM2.0 229193002308 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 229193002309 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 229193002310 catalytic loop [active] 229193002311 iron binding site [ion binding]; other site 229193002312 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 229193002313 L-aspartate oxidase; Provisional; Region: PRK06175 229193002314 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 229193002315 poxB regulator PoxA; Provisional; Region: PRK09350 229193002316 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 229193002317 motif 1; other site 229193002318 dimer interface [polypeptide binding]; other site 229193002319 active site 229193002320 motif 2; other site 229193002321 motif 3; other site 229193002322 putative mechanosensitive channel protein; Provisional; Region: PRK10929 229193002323 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 229193002324 Mechanosensitive ion channel; Region: MS_channel; pfam00924 229193002325 probable transmembrane helix predicted by TMHMM2.0 229193002326 probable transmembrane helix predicted by TMHMM2.0 229193002327 probable transmembrane helix predicted by TMHMM2.0 229193002328 probable transmembrane helix predicted by TMHMM2.0 229193002329 probable transmembrane helix predicted by TMHMM2.0 229193002330 probable transmembrane helix predicted by TMHMM2.0 229193002331 probable transmembrane helix predicted by TMHMM2.0 229193002332 probable transmembrane helix predicted by TMHMM2.0 229193002333 probable transmembrane helix predicted by TMHMM2.0 229193002334 probable transmembrane helix predicted by TMHMM2.0 229193002335 probable transmembrane helix predicted by TMHMM2.0 229193002336 ProfileScan match to entry PS50322 GLN_RICH, E-value 16.843 229193002337 probable transmembrane helix predicted by TMHMM2.0 229193002338 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 229193002339 GTPase RsgA; Reviewed; Region: PRK12288 229193002340 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 229193002341 RNA binding site [nucleotide binding]; other site 229193002342 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 229193002343 GTPase/Zn-binding domain interface [polypeptide binding]; other site 229193002344 GTP/Mg2+ binding site [chemical binding]; other site 229193002345 G4 box; other site 229193002346 G5 box; other site 229193002347 G1 box; other site 229193002348 Switch I region; other site 229193002349 G2 box; other site 229193002350 G3 box; other site 229193002351 Switch II region; other site 229193002352 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 229193002353 catalytic site [active] 229193002354 putative active site [active] 229193002355 putative substrate binding site [chemical binding]; other site 229193002356 dimer interface [polypeptide binding]; other site 229193002357 epoxyqueuosine reductase; Region: TIGR00276 229193002358 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 229193002359 putative carbohydrate kinase; Provisional; Region: PRK10565 229193002360 Uncharacterized conserved protein [Function unknown]; Region: COG0062 229193002361 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 229193002362 putative substrate binding site [chemical binding]; other site 229193002363 putative ATP binding site [chemical binding]; other site 229193002364 ADP-binding protein; Provisional; Region: PRK10646 229193002365 probable transmembrane helix predicted by TMHMM2.0 229193002366 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 229193002367 AMIN domain; Region: AMIN; pfam11741 229193002368 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 229193002369 active site 229193002370 metal binding site [ion binding]; metal-binding site 229193002371 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 229193002372 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 229193002373 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 229193002374 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 229193002375 probable transmembrane helix predicted by TMHMM2.0 229193002376 BlastProDom match to entry PD002984 sp_P26365_AMIB_ECOLI, E-value 5e-46 229193002377 BlastProDom match to entry PD002984 sp_P26365_AMIB_ECOLI, E-value 2e-30 229193002378 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 229193002379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193002380 ATP binding site [chemical binding]; other site 229193002381 Mg2+ binding site [ion binding]; other site 229193002382 G-X-G motif; other site 229193002383 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 229193002384 ATP binding site [chemical binding]; other site 229193002385 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 229193002386 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 229193002387 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 229193002388 bacterial Hfq-like; Region: Hfq; cd01716 229193002389 hexamer interface [polypeptide binding]; other site 229193002390 Sm1 motif; other site 229193002391 RNA binding site [nucleotide binding]; other site 229193002392 Sm2 motif; other site 229193002393 GTPase HflX; Provisional; Region: PRK11058 229193002394 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 229193002395 HflX GTPase family; Region: HflX; cd01878 229193002396 G1 box; other site 229193002397 GTP/Mg2+ binding site [chemical binding]; other site 229193002398 Switch I region; other site 229193002399 G2 box; other site 229193002400 G3 box; other site 229193002401 Switch II region; other site 229193002402 G4 box; other site 229193002403 G5 box; other site 229193002404 FtsH protease regulator HflK; Provisional; Region: PRK10930 229193002405 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 229193002406 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 229193002407 probable transmembrane helix predicted by TMHMM2.0 229193002408 FtsH protease regulator HflC; Provisional; Region: PRK11029 229193002409 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 229193002410 probable transmembrane helix predicted by TMHMM2.0 229193002411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 229193002412 probable transmembrane helix predicted by TMHMM2.0 229193002413 probable transmembrane helix predicted by TMHMM2.0 229193002414 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 229193002415 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 229193002416 GDP-binding site [chemical binding]; other site 229193002417 ACT binding site; other site 229193002418 IMP binding site; other site 229193002419 transcriptional repressor NsrR; Provisional; Region: PRK11014 229193002420 Rrf2 family protein; Region: rrf2_super; TIGR00738 229193002421 exoribonuclease R; Provisional; Region: PRK11642 229193002422 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 229193002423 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 229193002424 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 229193002425 RNB domain; Region: RNB; pfam00773 229193002426 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 229193002427 RNA binding site [nucleotide binding]; other site 229193002428 ProfileScan match to entry PS50318 LYS_RICH, E-value 8.639 229193002429 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 229193002430 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 229193002431 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 229193002432 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 229193002433 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 229193002434 active site 229193002435 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 229193002436 probable transmembrane helix predicted by TMHMM2.0 229193002437 probable transmembrane helix predicted by TMHMM2.0 229193002438 esterase; Provisional; Region: PRK10566 229193002439 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 229193002440 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 229193002441 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 229193002442 dimer interface [polypeptide binding]; other site 229193002443 ssDNA binding site [nucleotide binding]; other site 229193002444 tetramer (dimer of dimers) interface [polypeptide binding]; other site 229193002445 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 229193002446 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 229193002447 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 229193002448 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 229193002449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193002450 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193002451 DNA-binding interface [nucleotide binding]; DNA binding site 229193002452 Integrase core domain; Region: rve; pfam00665 229193002453 transposase/IS protein; Provisional; Region: PRK09183 229193002454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193002455 Walker A motif; other site 229193002456 ATP binding site [chemical binding]; other site 229193002457 Walker B motif; other site 229193002458 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193002459 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 229193002460 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 229193002461 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 229193002462 HMMPfam match to entry PF04225 OapA, E-value 1.3e-10 229193002463 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 229193002464 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 229193002465 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 229193002466 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 229193002467 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 229193002468 Hemerythrin-like domain; Region: Hr-like; cd12108 229193002469 Fe binding site [ion binding]; other site 229193002470 HMMPfam match to entry PF04405 ScdA_N, E-value 2.7e-25 229193002471 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 229193002472 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 229193002473 active site 229193002474 metal binding site [ion binding]; metal-binding site 229193002475 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 229193002476 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 229193002477 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 229193002478 active site 229193002479 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 229193002480 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 229193002481 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 229193002482 Domain of unknown function DUF21; Region: DUF21; pfam01595 229193002483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 229193002484 Transporter associated domain; Region: CorC_HlyC; smart01091 229193002485 probable transmembrane helix predicted by TMHMM2.0 229193002486 probable transmembrane helix predicted by TMHMM2.0 229193002487 probable transmembrane helix predicted by TMHMM2.0 229193002488 probable transmembrane helix predicted by TMHMM2.0 229193002489 methionine sulfoxide reductase A; Provisional; Region: PRK00058 229193002490 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 229193002491 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 229193002492 Surface antigen; Region: Bac_surface_Ag; pfam01103 229193002493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 229193002494 Family of unknown function (DUF490); Region: DUF490; pfam04357 229193002495 probable transmembrane helix predicted by TMHMM2.0 229193002496 HMMPfam match to entry PF04357 DUF490, E-value 5e-144 229193002497 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 229193002498 putative active site pocket [active] 229193002499 dimerization interface [polypeptide binding]; other site 229193002500 putative catalytic residue [active] 229193002501 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 229193002502 dimer interface [polypeptide binding]; other site 229193002503 substrate binding site [chemical binding]; other site 229193002504 metal binding sites [ion binding]; metal-binding site 229193002505 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 229193002506 AMP binding site [chemical binding]; other site 229193002507 metal binding site [ion binding]; metal-binding site 229193002508 active site 229193002509 probable transmembrane helix predicted by TMHMM2.0 229193002510 probable transmembrane helix predicted by TMHMM2.0 229193002511 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 229193002512 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 229193002513 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 229193002514 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 229193002515 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 229193002516 arginine repressor; Provisional; Region: PRK05066 229193002517 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 229193002518 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 229193002519 malate dehydrogenase; Provisional; Region: PRK05086 229193002520 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 229193002521 NAD binding site [chemical binding]; other site 229193002522 dimerization interface [polypeptide binding]; other site 229193002523 Substrate binding site [chemical binding]; other site 229193002524 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 229193002525 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 229193002526 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 229193002527 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 229193002528 substrate binding pocket [chemical binding]; other site 229193002529 chain length determination region; other site 229193002530 substrate-Mg2+ binding site; other site 229193002531 catalytic residues [active] 229193002532 aspartate-rich region 1; other site 229193002533 active site lid residues [active] 229193002534 aspartate-rich region 2; other site 229193002535 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 229193002536 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 229193002537 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 229193002538 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 229193002539 EamA-like transporter family; Region: EamA; pfam00892 229193002540 probable transmembrane helix predicted by TMHMM2.0 229193002541 probable transmembrane helix predicted by TMHMM2.0 229193002542 probable transmembrane helix predicted by TMHMM2.0 229193002543 probable transmembrane helix predicted by TMHMM2.0 229193002544 probable transmembrane helix predicted by TMHMM2.0 229193002545 probable transmembrane helix predicted by TMHMM2.0 229193002546 probable transmembrane helix predicted by TMHMM2.0 229193002547 probable transmembrane helix predicted by TMHMM2.0 229193002548 probable transmembrane helix predicted by TMHMM2.0 229193002549 probable transmembrane helix predicted by TMHMM2.0 229193002550 GTPase CgtA; Reviewed; Region: obgE; PRK12298 229193002551 GTP1/OBG; Region: GTP1_OBG; pfam01018 229193002552 Obg GTPase; Region: Obg; cd01898 229193002553 G1 box; other site 229193002554 GTP/Mg2+ binding site [chemical binding]; other site 229193002555 Switch I region; other site 229193002556 G2 box; other site 229193002557 G3 box; other site 229193002558 Switch II region; other site 229193002559 G4 box; other site 229193002560 G5 box; other site 229193002561 sensor protein BasS/PmrB; Provisional; Region: PRK10755 229193002562 HAMP domain; Region: HAMP; pfam00672 229193002563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193002564 dimer interface [polypeptide binding]; other site 229193002565 phosphorylation site [posttranslational modification] 229193002566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193002567 ATP binding site [chemical binding]; other site 229193002568 Mg2+ binding site [ion binding]; other site 229193002569 G-X-G motif; other site 229193002570 probable transmembrane helix predicted by TMHMM2.0 229193002571 probable transmembrane helix predicted by TMHMM2.0 229193002572 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 229193002573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193002574 active site 229193002575 phosphorylation site [posttranslational modification] 229193002576 intermolecular recognition site; other site 229193002577 dimerization interface [polypeptide binding]; other site 229193002578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193002579 DNA binding site [nucleotide binding] 229193002580 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 229193002581 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 229193002582 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 229193002583 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 229193002584 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 229193002585 RNA-binding protein YhbY; Provisional; Region: PRK10343 229193002586 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 229193002587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193002588 S-adenosylmethionine binding site [chemical binding]; other site 229193002589 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 229193002590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193002591 Walker A motif; other site 229193002592 ATP binding site [chemical binding]; other site 229193002593 Walker B motif; other site 229193002594 arginine finger; other site 229193002595 Peptidase family M41; Region: Peptidase_M41; pfam01434 229193002596 probable transmembrane helix predicted by TMHMM2.0 229193002597 probable transmembrane helix predicted by TMHMM2.0 229193002598 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 229193002599 dihydropteroate synthase; Region: DHPS; TIGR01496 229193002600 substrate binding pocket [chemical binding]; other site 229193002601 dimer interface [polypeptide binding]; other site 229193002602 inhibitor binding site; inhibition site 229193002603 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 229193002604 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 229193002605 active site 229193002606 substrate binding site [chemical binding]; other site 229193002607 metal binding site [ion binding]; metal-binding site 229193002608 Preprotein translocase SecG subunit; Region: SecG; pfam03840 229193002609 probable transmembrane helix predicted by TMHMM2.0 229193002610 probable transmembrane helix predicted by TMHMM2.0 229193002611 ribosome maturation protein RimP; Reviewed; Region: PRK00092 229193002612 Sm and related proteins; Region: Sm_like; cl00259 229193002613 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 229193002614 putative oligomer interface [polypeptide binding]; other site 229193002615 putative RNA binding site [nucleotide binding]; other site 229193002616 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 229193002617 NusA N-terminal domain; Region: NusA_N; pfam08529 229193002618 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 229193002619 RNA binding site [nucleotide binding]; other site 229193002620 homodimer interface [polypeptide binding]; other site 229193002621 NusA-like KH domain; Region: KH_5; pfam13184 229193002622 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 229193002623 G-X-X-G motif; other site 229193002624 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 229193002625 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 229193002626 BlastProDom match to entry PD002633 sp_P03003_NUSA_ECOLI, E-value 6e-47 229193002627 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 229193002628 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 229193002629 translation initiation factor IF-2; Validated; Region: infB; PRK05306 229193002630 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 229193002631 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 229193002632 G1 box; other site 229193002633 putative GEF interaction site [polypeptide binding]; other site 229193002634 GTP/Mg2+ binding site [chemical binding]; other site 229193002635 Switch I region; other site 229193002636 G2 box; other site 229193002637 G3 box; other site 229193002638 Switch II region; other site 229193002639 G4 box; other site 229193002640 G5 box; other site 229193002641 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 229193002642 Translation-initiation factor 2; Region: IF-2; pfam11987 229193002643 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 229193002644 ProfileScan match to entry PS50313 GLU_RICH, E-value 9.543 229193002645 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 229193002646 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 229193002647 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 229193002648 RNA binding site [nucleotide binding]; other site 229193002649 active site 229193002650 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 229193002651 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 229193002652 16S/18S rRNA binding site [nucleotide binding]; other site 229193002653 S13e-L30e interaction site [polypeptide binding]; other site 229193002654 25S rRNA binding site [nucleotide binding]; other site 229193002655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 229193002656 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193002657 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193002658 putative transposase OrfB; Reviewed; Region: PHA02517 229193002659 HTH-like domain; Region: HTH_21; pfam13276 229193002660 Integrase core domain; Region: rve; pfam00665 229193002661 Integrase core domain; Region: rve_2; pfam13333 229193002662 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 229193002663 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 229193002664 RNase E interface [polypeptide binding]; other site 229193002665 trimer interface [polypeptide binding]; other site 229193002666 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 229193002667 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 229193002668 RNase E interface [polypeptide binding]; other site 229193002669 trimer interface [polypeptide binding]; other site 229193002670 active site 229193002671 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 229193002672 putative nucleic acid binding region [nucleotide binding]; other site 229193002673 G-X-X-G motif; other site 229193002674 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 229193002675 RNA binding site [nucleotide binding]; other site 229193002676 domain interface; other site 229193002677 lipoprotein NlpI; Provisional; Region: PRK11189 229193002678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 229193002679 binding surface 229193002680 TPR motif; other site 229193002681 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 229193002682 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 229193002683 ATP binding site [chemical binding]; other site 229193002684 Mg++ binding site [ion binding]; other site 229193002685 motif III; other site 229193002686 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193002687 nucleotide binding region [chemical binding]; other site 229193002688 ATP-binding site [chemical binding]; other site 229193002689 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 229193002690 putative RNA binding site [nucleotide binding]; other site 229193002691 Cold shock protein DEAD box A; Region: DEADboxA; pfam12343 229193002692 ProfileScan match to entry PS50323 ARG_RICH, E-value 10.703 229193002693 probable transmembrane helix predicted by TMHMM2.0 229193002694 Phage-related protein [Function unknown]; Region: COG4679 229193002695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 229193002696 non-specific DNA binding site [nucleotide binding]; other site 229193002697 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 229193002698 salt bridge; other site 229193002699 sequence-specific DNA binding site [nucleotide binding]; other site 229193002700 hypothetical protein; Provisional; Region: PRK10508 229193002701 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 229193002702 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 229193002703 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 229193002704 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 229193002705 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 229193002706 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193002707 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 229193002708 Protein export membrane protein; Region: SecD_SecF; cl14618 229193002709 probable transmembrane helix predicted by TMHMM2.0 229193002710 probable transmembrane helix predicted by TMHMM2.0 229193002711 probable transmembrane helix predicted by TMHMM2.0 229193002712 probable transmembrane helix predicted by TMHMM2.0 229193002713 probable transmembrane helix predicted by TMHMM2.0 229193002714 probable transmembrane helix predicted by TMHMM2.0 229193002715 probable transmembrane helix predicted by TMHMM2.0 229193002716 probable transmembrane helix predicted by TMHMM2.0 229193002717 probable transmembrane helix predicted by TMHMM2.0 229193002718 probable transmembrane helix predicted by TMHMM2.0 229193002719 probable transmembrane helix predicted by TMHMM2.0 229193002720 probable transmembrane helix predicted by TMHMM2.0 229193002721 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 229193002722 putative protease; Provisional; Region: PRK15447 229193002723 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 229193002724 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 229193002725 Peptidase family U32; Region: Peptidase_U32; pfam01136 229193002726 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 229193002727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 229193002728 Coenzyme A binding pocket [chemical binding]; other site 229193002729 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 229193002730 GIY-YIG motif/motif A; other site 229193002731 putative active site [active] 229193002732 putative metal binding site [ion binding]; other site 229193002733 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 229193002734 Alginate lyase; Region: Alginate_lyase; pfam05426 229193002735 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 229193002736 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 229193002737 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 229193002738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193002739 dimer interface [polypeptide binding]; other site 229193002740 putative PBP binding loops; other site 229193002741 ABC-ATPase subunit interface; other site 229193002742 probable transmembrane helix predicted by TMHMM2.0 229193002743 probable transmembrane helix predicted by TMHMM2.0 229193002744 probable transmembrane helix predicted by TMHMM2.0 229193002745 probable transmembrane helix predicted by TMHMM2.0 229193002746 probable transmembrane helix predicted by TMHMM2.0 229193002747 probable transmembrane helix predicted by TMHMM2.0 229193002748 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 229193002749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193002750 dimer interface [polypeptide binding]; other site 229193002751 conserved gate region; other site 229193002752 putative PBP binding loops; other site 229193002753 ABC-ATPase subunit interface; other site 229193002754 probable transmembrane helix predicted by TMHMM2.0 229193002755 probable transmembrane helix predicted by TMHMM2.0 229193002756 probable transmembrane helix predicted by TMHMM2.0 229193002757 probable transmembrane helix predicted by TMHMM2.0 229193002758 probable transmembrane helix predicted by TMHMM2.0 229193002759 probable transmembrane helix predicted by TMHMM2.0 229193002760 Alginate lyase; Region: Alginate_lyase; pfam05426 229193002761 hypothetical protein; Provisional; Region: PRK03467 229193002762 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 229193002763 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 229193002764 NAD binding site [chemical binding]; other site 229193002765 active site 229193002766 putative hydrolase; Provisional; Region: PRK02113 229193002767 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 229193002768 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 229193002769 Guanylate kinase; Region: Guanylate_kin; pfam00625 229193002770 active site 229193002771 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 229193002772 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 229193002773 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 229193002774 active site 229193002775 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 229193002776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193002777 Walker A/P-loop; other site 229193002778 ATP binding site [chemical binding]; other site 229193002779 Q-loop/lid; other site 229193002780 ABC transporter signature motif; other site 229193002781 Walker B; other site 229193002782 D-loop; other site 229193002783 H-loop/switch region; other site 229193002784 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 229193002785 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193002786 Walker A/P-loop; other site 229193002787 ATP binding site [chemical binding]; other site 229193002788 Q-loop/lid; other site 229193002789 ABC transporter signature motif; other site 229193002790 Walker B; other site 229193002791 D-loop; other site 229193002792 H-loop/switch region; other site 229193002793 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 229193002794 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 229193002795 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 229193002796 ProfileScan match to entry PS50324 SER_RICH, E-value 9.520 229193002797 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 229193002798 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnG; COG3624 229193002799 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 229193002800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 229193002801 DNA-binding site [nucleotide binding]; DNA binding site 229193002802 UTRA domain; Region: UTRA; pfam07702 229193002803 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 229193002804 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 229193002805 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 229193002806 ATP cone domain; Region: ATP-cone; pfam03477 229193002807 Class III ribonucleotide reductase; Region: RNR_III; cd01675 229193002808 effector binding site; other site 229193002809 active site 229193002810 Zn binding site [ion binding]; other site 229193002811 glycine loop; other site 229193002812 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 229193002813 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193002814 Walker A/P-loop; other site 229193002815 ATP binding site [chemical binding]; other site 229193002816 Q-loop/lid; other site 229193002817 ABC transporter signature motif; other site 229193002818 Walker B; other site 229193002819 D-loop; other site 229193002820 H-loop/switch region; other site 229193002821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193002822 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 229193002823 Walker A/P-loop; other site 229193002824 ATP binding site [chemical binding]; other site 229193002825 Q-loop/lid; other site 229193002826 ABC transporter signature motif; other site 229193002827 Walker B; other site 229193002828 D-loop; other site 229193002829 H-loop/switch region; other site 229193002830 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 229193002831 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 229193002832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193002833 dimer interface [polypeptide binding]; other site 229193002834 conserved gate region; other site 229193002835 ABC-ATPase subunit interface; other site 229193002836 probable transmembrane helix predicted by TMHMM2.0 229193002837 probable transmembrane helix predicted by TMHMM2.0 229193002838 probable transmembrane helix predicted by TMHMM2.0 229193002839 probable transmembrane helix predicted by TMHMM2.0 229193002840 probable transmembrane helix predicted by TMHMM2.0 229193002841 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 229193002842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193002843 dimer interface [polypeptide binding]; other site 229193002844 conserved gate region; other site 229193002845 putative PBP binding loops; other site 229193002846 ABC-ATPase subunit interface; other site 229193002847 probable transmembrane helix predicted by TMHMM2.0 229193002848 probable transmembrane helix predicted by TMHMM2.0 229193002849 probable transmembrane helix predicted by TMHMM2.0 229193002850 probable transmembrane helix predicted by TMHMM2.0 229193002851 probable transmembrane helix predicted by TMHMM2.0 229193002852 probable transmembrane helix predicted by TMHMM2.0 229193002853 Contains Bacterial extracellular solute-binding protein, family 5 (Interpro|IPR000914, (GO:0006810)) . Contains Bacterial extracellular solute-binding protein, family 5 (Interpro|IPR000914, (GO:0006810)) 229193002854 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 229193002855 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 229193002856 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 229193002857 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 229193002858 RNase E inhibitor protein; Provisional; Region: PRK11191 229193002859 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 229193002860 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 229193002861 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 229193002862 HIGH motif; other site 229193002863 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 229193002864 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 229193002865 active site 229193002866 KMSKS motif; other site 229193002867 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 229193002868 tRNA binding surface [nucleotide binding]; other site 229193002869 anticodon binding site; other site 229193002870 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 229193002871 DNA polymerase III subunit chi; Validated; Region: PRK05728 229193002872 HMMPfam match to entry PF04364 DNA_pol3_chi, E-value 3e-66 229193002873 multifunctional aminopeptidase A; Provisional; Region: PRK00913 229193002874 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 229193002875 interface (dimer of trimers) [polypeptide binding]; other site 229193002876 Substrate-binding/catalytic site; other site 229193002877 Zn-binding sites [ion binding]; other site 229193002878 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 229193002879 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 229193002880 probable transmembrane helix predicted by TMHMM2.0 229193002881 probable transmembrane helix predicted by TMHMM2.0 229193002882 probable transmembrane helix predicted by TMHMM2.0 229193002883 probable transmembrane helix predicted by TMHMM2.0 229193002884 probable transmembrane helix predicted by TMHMM2.0 229193002885 probable transmembrane helix predicted by TMHMM2.0 229193002886 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 229193002887 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 229193002888 probable transmembrane helix predicted by TMHMM2.0 229193002889 probable transmembrane helix predicted by TMHMM2.0 229193002890 probable transmembrane helix predicted by TMHMM2.0 229193002891 probable transmembrane helix predicted by TMHMM2.0 229193002892 probable transmembrane helix predicted by TMHMM2.0 229193002893 probable transmembrane helix predicted by TMHMM2.0 229193002894 integrase; Provisional; Region: PRK09692 229193002895 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 229193002896 active site 229193002897 Int/Topo IB signature motif; other site 229193002898 Uncharacterized conserved protein [Function unknown]; Region: COG1479 229193002899 Protein of unknown function DUF262; Region: DUF262; pfam03235 229193002900 Protein of unknown function DUF262; Region: DUF262; pfam03235 229193002901 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 229193002902 transposase/IS protein; Provisional; Region: PRK09183 229193002903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193002904 Walker A motif; other site 229193002905 ATP binding site [chemical binding]; other site 229193002906 Walker B motif; other site 229193002907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193002908 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193002909 DNA-binding interface [nucleotide binding]; DNA binding site 229193002910 Integrase core domain; Region: rve; pfam00665 229193002911 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193002912 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 229193002913 30S subunit binding site; other site 229193002914 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 229193002915 BlastProDom match to entry PD013537 sp_P77146_YFIO_ECOLI, E-value e-112 229193002916 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 229193002917 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 229193002918 RNA binding surface [nucleotide binding]; other site 229193002919 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 229193002920 active site 229193002921 hypothetical protein; Provisional; Region: PRK10723 229193002922 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 229193002923 protein disaggregation chaperone; Provisional; Region: PRK10865 229193002924 Clp amino terminal domain; Region: Clp_N; pfam02861 229193002925 Clp amino terminal domain; Region: Clp_N; pfam02861 229193002926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193002927 Walker A motif; other site 229193002928 ATP binding site [chemical binding]; other site 229193002929 Walker B motif; other site 229193002930 arginine finger; other site 229193002931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193002932 Walker A motif; other site 229193002933 ATP binding site [chemical binding]; other site 229193002934 Walker B motif; other site 229193002935 arginine finger; other site 229193002936 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 229193002937 rRNA operon 229193002938 lipoprotein; Provisional; Region: PRK10759 229193002939 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 229193002940 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 229193002941 domain interface [polypeptide binding]; other site 229193002942 putative active site [active] 229193002943 catalytic site [active] 229193002944 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 229193002945 domain interface [polypeptide binding]; other site 229193002946 putative active site [active] 229193002947 catalytic site [active] 229193002948 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 229193002949 CoA binding domain; Region: CoA_binding_2; pfam13380 229193002950 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 229193002951 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 229193002952 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 229193002953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 229193002954 Coenzyme A binding pocket [chemical binding]; other site 229193002955 Uncharacterized conserved protein [Function unknown]; Region: COG3148 229193002956 thioredoxin 2; Provisional; Region: PRK10996 229193002957 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 229193002958 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 229193002959 catalytic residues [active] 229193002960 putative methyltransferase; Provisional; Region: PRK10864 229193002961 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 229193002962 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 229193002963 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 229193002964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193002965 putative substrate translocation pore; other site 229193002966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193002967 probable transmembrane helix predicted by TMHMM2.0 229193002968 probable transmembrane helix predicted by TMHMM2.0 229193002969 probable transmembrane helix predicted by TMHMM2.0 229193002970 probable transmembrane helix predicted by TMHMM2.0 229193002971 probable transmembrane helix predicted by TMHMM2.0 229193002972 probable transmembrane helix predicted by TMHMM2.0 229193002973 probable transmembrane helix predicted by TMHMM2.0 229193002974 probable transmembrane helix predicted by TMHMM2.0 229193002975 probable transmembrane helix predicted by TMHMM2.0 229193002976 probable transmembrane helix predicted by TMHMM2.0 229193002977 probable transmembrane helix predicted by TMHMM2.0 229193002978 probable transmembrane helix predicted by TMHMM2.0 229193002979 probable transmembrane helix predicted by TMHMM2.0 229193002980 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 229193002981 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 229193002982 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193002983 probable transmembrane helix predicted by TMHMM2.0 229193002984 transcriptional repressor MprA; Provisional; Region: PRK10870 229193002985 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 229193002986 putative L-valine exporter; Provisional; Region: PRK10408 229193002987 probable transmembrane helix predicted by TMHMM2.0 229193002988 probable transmembrane helix predicted by TMHMM2.0 229193002989 probable transmembrane helix predicted by TMHMM2.0 229193002990 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 229193002991 probable transmembrane helix predicted by TMHMM2.0 229193002992 probable transmembrane helix predicted by TMHMM2.0 229193002993 probable transmembrane helix predicted by TMHMM2.0 229193002994 probable transmembrane helix predicted by TMHMM2.0 229193002995 probable transmembrane helix predicted by TMHMM2.0 229193002996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193002997 putative substrate translocation pore; other site 229193002998 probable transmembrane helix predicted by TMHMM2.0 229193002999 probable transmembrane helix predicted by TMHMM2.0 229193003000 probable transmembrane helix predicted by TMHMM2.0 229193003001 probable transmembrane helix predicted by TMHMM2.0 229193003002 probable transmembrane helix predicted by TMHMM2.0 229193003003 probable transmembrane helix predicted by TMHMM2.0 229193003004 probable transmembrane helix predicted by TMHMM2.0 229193003005 probable transmembrane helix predicted by TMHMM2.0 229193003006 probable transmembrane helix predicted by TMHMM2.0 229193003007 probable transmembrane helix predicted by TMHMM2.0 229193003008 probable transmembrane helix predicted by TMHMM2.0 229193003009 probable transmembrane helix predicted by TMHMM2.0 229193003010 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 229193003011 amidase; Provisional; Region: PRK09201 229193003012 Amidase; Region: Amidase; cl11426 229193003013 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 229193003014 probable transmembrane helix predicted by TMHMM2.0 229193003015 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 229193003016 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 229193003017 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 229193003018 putative active site [active] 229193003019 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 229193003020 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193003021 substrate binding pocket [chemical binding]; other site 229193003022 membrane-bound complex binding site; other site 229193003023 hinge residues; other site 229193003024 probable transmembrane helix predicted by TMHMM2.0 229193003025 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 229193003026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193003027 dimer interface [polypeptide binding]; other site 229193003028 conserved gate region; other site 229193003029 putative PBP binding loops; other site 229193003030 ABC-ATPase subunit interface; other site 229193003031 probable transmembrane helix predicted by TMHMM2.0 229193003032 probable transmembrane helix predicted by TMHMM2.0 229193003033 probable transmembrane helix predicted by TMHMM2.0 229193003034 probable transmembrane helix predicted by TMHMM2.0 229193003035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193003036 dimer interface [polypeptide binding]; other site 229193003037 conserved gate region; other site 229193003038 putative PBP binding loops; other site 229193003039 ABC-ATPase subunit interface; other site 229193003040 probable transmembrane helix predicted by TMHMM2.0 229193003041 probable transmembrane helix predicted by TMHMM2.0 229193003042 probable transmembrane helix predicted by TMHMM2.0 229193003043 probable transmembrane helix predicted by TMHMM2.0 229193003044 probable transmembrane helix predicted by TMHMM2.0 229193003045 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 229193003046 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 229193003047 Walker A/P-loop; other site 229193003048 ATP binding site [chemical binding]; other site 229193003049 Q-loop/lid; other site 229193003050 ABC transporter signature motif; other site 229193003051 Walker B; other site 229193003052 D-loop; other site 229193003053 H-loop/switch region; other site 229193003054 BlastProDom match to entry PD039360 sp_Q57585_Y121_METJA, E-value 2e-07 229193003055 similar to gi|16126841|ref|NP_421405.1|, aminotransferase, class V [Caulobacter crescentus CB15] ,and gi|21106370|gb|AAM35192.1| (AE011655) serine-pyruvate aminotransferase [Xanthomonas axonopodis pv. citri str. 306],(len:418 aa); disrupted by IS100 element 229193003056 transposase/IS protein; Provisional; Region: PRK09183 229193003057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193003058 Walker A motif; other site 229193003059 ATP binding site [chemical binding]; other site 229193003060 Walker B motif; other site 229193003061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193003062 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193003063 DNA-binding interface [nucleotide binding]; DNA binding site 229193003064 Integrase core domain; Region: rve; pfam00665 229193003065 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 229193003066 allantoate amidohydrolase; Reviewed; Region: PRK09290 229193003067 active site 229193003068 metal binding site [ion binding]; metal-binding site 229193003069 dimer interface [polypeptide binding]; other site 229193003070 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 229193003071 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 229193003072 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 229193003073 probable transmembrane helix predicted by TMHMM2.0 229193003074 ProfileScan match to entry PS50315 GLY_RICH, E-value 10.553 229193003075 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 229193003076 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 229193003077 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 229193003078 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 229193003079 active site 229193003080 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 229193003081 probable transmembrane helix predicted by TMHMM2.0 229193003082 probable transmembrane helix predicted by TMHMM2.0 229193003083 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 229193003084 dimer interface [polypeptide binding]; other site 229193003085 active site 229193003086 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 229193003087 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 229193003088 putative active site [active] 229193003089 putative dimer interface [polypeptide binding]; other site 229193003090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 229193003091 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 229193003092 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 229193003093 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 229193003094 E3 interaction surface; other site 229193003095 lipoyl attachment site [posttranslational modification]; other site 229193003096 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 229193003097 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 229193003098 probable transmembrane helix predicted by TMHMM2.0 229193003099 probable transmembrane helix predicted by TMHMM2.0 229193003100 probable transmembrane helix predicted by TMHMM2.0 229193003101 probable transmembrane helix predicted by TMHMM2.0 229193003102 probable transmembrane helix predicted by TMHMM2.0 229193003103 probable transmembrane helix predicted by TMHMM2.0 229193003104 probable transmembrane helix predicted by TMHMM2.0 229193003105 probable transmembrane helix predicted by TMHMM2.0 229193003106 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 229193003107 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 229193003108 probable transmembrane helix predicted by TMHMM2.0 229193003109 HMMPfam match to entry PF04205 FMN_bind, E-value 1.1e-40 229193003110 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 229193003111 probable transmembrane helix predicted by TMHMM2.0 229193003112 probable transmembrane helix predicted by TMHMM2.0 229193003113 probable transmembrane helix predicted by TMHMM2.0 229193003114 probable transmembrane helix predicted by TMHMM2.0 229193003115 probable transmembrane helix predicted by TMHMM2.0 229193003116 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 229193003117 probable transmembrane helix predicted by TMHMM2.0 229193003118 probable transmembrane helix predicted by TMHMM2.0 229193003119 probable transmembrane helix predicted by TMHMM2.0 229193003120 probable transmembrane helix predicted by TMHMM2.0 229193003121 probable transmembrane helix predicted by TMHMM2.0 229193003122 probable transmembrane helix predicted by TMHMM2.0 229193003123 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 229193003124 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 229193003125 catalytic loop [active] 229193003126 iron binding site [ion binding]; other site 229193003127 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 229193003128 FAD binding pocket [chemical binding]; other site 229193003129 FAD binding motif [chemical binding]; other site 229193003130 phosphate binding motif [ion binding]; other site 229193003131 beta-alpha-beta structure motif; other site 229193003132 NAD binding pocket [chemical binding]; other site 229193003133 probable transmembrane helix predicted by TMHMM2.0 229193003134 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 229193003135 ApbE family; Region: ApbE; pfam02424 229193003136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 229193003137 probable transmembrane helix predicted by TMHMM2.0 229193003138 HMMPfam match to entry PF04400 DUF539, E-value 5.1e-24 229193003139 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 229193003140 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 229193003141 putative active site [active] 229193003142 catalytic site [active] 229193003143 putative metal binding site [ion binding]; other site 229193003144 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 229193003145 active site 229193003146 DNA polymerase IV; Validated; Region: PRK02406 229193003147 DNA binding site [nucleotide binding] 229193003148 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 229193003149 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 229193003150 metal binding site [ion binding]; metal-binding site 229193003151 dimer interface [polypeptide binding]; other site 229193003152 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193003153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193003154 LysR substrate binding domain; Region: LysR_substrate; pfam03466 229193003155 dimerization interface [polypeptide binding]; other site 229193003156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 229193003157 Chitin binding domain; Region: Chitin_bind_3; pfam03067 229193003158 PKD domain; Region: PKD; pfam00801 229193003159 probable transmembrane helix predicted by TMHMM2.0 229193003160 probable transmembrane helix predicted by TMHMM2.0 229193003161 probable transmembrane helix predicted by TMHMM2.0 229193003162 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 229193003163 active site 229193003164 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 229193003165 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 229193003166 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 229193003167 gamma-glutamyl kinase; Provisional; Region: PRK05429 229193003168 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 229193003169 nucleotide binding site [chemical binding]; other site 229193003170 homotetrameric interface [polypeptide binding]; other site 229193003171 putative phosphate binding site [ion binding]; other site 229193003172 putative allosteric binding site; other site 229193003173 PUA domain; Region: PUA; pfam01472 229193003174 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 229193003175 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 229193003176 putative catalytic cysteine [active] 229193003177 Flagellar regulator YcgR; Region: YcgR; pfam07317 229193003178 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 229193003179 PilZ domain; Region: PilZ; pfam07238 229193003180 probable transmembrane helix predicted by TMHMM2.0 229193003181 probable transmembrane helix predicted by TMHMM2.0 229193003182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193003183 Phospholipid N-methyltransferase [Lipid metabolism]; Region: COG3963 229193003184 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 229193003185 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 229193003186 ADP binding site [chemical binding]; other site 229193003187 magnesium binding site [ion binding]; other site 229193003188 putative shikimate binding site; other site 229193003189 BlastProDom match to entry PD004326 sp_P10880_AROL_ERWCH, E-value 2e-50 229193003190 hypothetical protein; Provisional; Region: PRK10579 229193003191 recombination associated protein; Reviewed; Region: rdgC; PRK00321 229193003192 HMMPfam match to entry PF04381 RdgC, E-value 1.7e-200 229193003193 fructokinase; Reviewed; Region: PRK09557 229193003194 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 229193003195 nucleotide binding site [chemical binding]; other site 229193003196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193003197 AAA domain; Region: AAA_23; pfam13476 229193003198 Walker A/P-loop; other site 229193003199 ATP binding site [chemical binding]; other site 229193003200 Q-loop/lid; other site 229193003201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193003202 ABC transporter signature motif; other site 229193003203 Walker B; other site 229193003204 D-loop; other site 229193003205 H-loop/switch region; other site 229193003206 ProfileScan match to entry PS50322 GLN_RICH, E-value 102.237 229193003207 exonuclease subunit SbcD; Provisional; Region: PRK10966 229193003208 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 229193003209 active site 229193003210 metal binding site [ion binding]; metal-binding site 229193003211 DNA binding site [nucleotide binding] 229193003212 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 229193003213 transcriptional regulator PhoB; Provisional; Region: PRK10161 229193003214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193003215 active site 229193003216 phosphorylation site [posttranslational modification] 229193003217 intermolecular recognition site; other site 229193003218 dimerization interface [polypeptide binding]; other site 229193003219 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193003220 DNA binding site [nucleotide binding] 229193003221 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 229193003222 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 229193003223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 229193003224 putative active site [active] 229193003225 heme pocket [chemical binding]; other site 229193003226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193003227 dimer interface [polypeptide binding]; other site 229193003228 phosphorylation site [posttranslational modification] 229193003229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193003230 ATP binding site [chemical binding]; other site 229193003231 Mg2+ binding site [ion binding]; other site 229193003232 G-X-G motif; other site 229193003233 probable transmembrane helix predicted by TMHMM2.0 229193003234 PBP superfamily domain; Region: PBP_like_2; cl17296 229193003235 BlastProDom match to entry PD002295 sp_O32484_O32484_ENTCL, E-value e-112 229193003236 BlastProDom match to entry PD002295 sp_Q9Z9M3_Q9Z9M3_PSEAE, E-value 4e-77 229193003237 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 229193003238 probable transmembrane helix predicted by TMHMM2.0 229193003239 probable transmembrane helix predicted by TMHMM2.0 229193003240 probable transmembrane helix predicted by TMHMM2.0 229193003241 probable transmembrane helix predicted by TMHMM2.0 229193003242 probable transmembrane helix predicted by TMHMM2.0 229193003243 probable transmembrane helix predicted by TMHMM2.0 229193003244 probable transmembrane helix predicted by TMHMM2.0 229193003245 probable transmembrane helix predicted by TMHMM2.0 229193003246 probable transmembrane helix predicted by TMHMM2.0 229193003247 probable transmembrane helix predicted by TMHMM2.0 229193003248 probable transmembrane helix predicted by TMHMM2.0 229193003249 probable transmembrane helix predicted by TMHMM2.0 229193003250 putative proline-specific permease; Provisional; Region: proY; PRK10580 229193003251 Spore germination protein; Region: Spore_permease; cl17796 229193003252 probable transmembrane helix predicted by TMHMM2.0 229193003253 probable transmembrane helix predicted by TMHMM2.0 229193003254 probable transmembrane helix predicted by TMHMM2.0 229193003255 probable transmembrane helix predicted by TMHMM2.0 229193003256 probable transmembrane helix predicted by TMHMM2.0 229193003257 probable transmembrane helix predicted by TMHMM2.0 229193003258 probable transmembrane helix predicted by TMHMM2.0 229193003259 probable transmembrane helix predicted by TMHMM2.0 229193003260 probable transmembrane helix predicted by TMHMM2.0 229193003261 probable transmembrane helix predicted by TMHMM2.0 229193003262 probable transmembrane helix predicted by TMHMM2.0 229193003263 probable transmembrane helix predicted by TMHMM2.0 229193003264 maltodextrin glucosidase; Provisional; Region: PRK10785 229193003265 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 229193003266 homodimer interface [polypeptide binding]; other site 229193003267 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 229193003268 active site 229193003269 homodimer interface [polypeptide binding]; other site 229193003270 catalytic site [active] 229193003271 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 229193003272 C factor cell-cell signaling protein; Provisional; Region: PRK09009 229193003273 NADP binding site [chemical binding]; other site 229193003274 homodimer interface [polypeptide binding]; other site 229193003275 active site 229193003276 Contains Gamma-glutamyltranspeptidase (Interpro|IPR000101, (GO:0003840)) . Contains Gamma-glutamyltranspeptidase (Interpro|IPR000101, (GO:0003840)) 229193003277 peroxidase; Provisional; Region: PRK15000 229193003278 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 229193003279 dimer interface [polypeptide binding]; other site 229193003280 decamer (pentamer of dimers) interface [polypeptide binding]; other site 229193003281 catalytic triad [active] 229193003282 peroxidatic and resolving cysteines [active] 229193003283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3124 229193003284 HMMPfam match to entry PF04336 DUF479, E-value 3.3e-82 229193003285 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 229193003286 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 229193003287 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 229193003288 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 229193003289 probable transmembrane helix predicted by TMHMM2.0 229193003290 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 229193003291 probable transmembrane helix predicted by TMHMM2.0 229193003292 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 229193003293 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 229193003294 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 229193003295 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 229193003296 probable transmembrane helix predicted by TMHMM2.0 229193003297 probable transmembrane helix predicted by TMHMM2.0 229193003298 probable transmembrane helix predicted by TMHMM2.0 229193003299 probable transmembrane helix predicted by TMHMM2.0 229193003300 probable transmembrane helix predicted by TMHMM2.0 229193003301 probable transmembrane helix predicted by TMHMM2.0 229193003302 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 229193003303 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 229193003304 Protein export membrane protein; Region: SecD_SecF; pfam02355 229193003305 probable transmembrane helix predicted by TMHMM2.0 229193003306 probable transmembrane helix predicted by TMHMM2.0 229193003307 probable transmembrane helix predicted by TMHMM2.0 229193003308 probable transmembrane helix predicted by TMHMM2.0 229193003309 probable transmembrane helix predicted by TMHMM2.0 229193003310 probable transmembrane helix predicted by TMHMM2.0 229193003311 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193003312 probable transmembrane helix predicted by TMHMM2.0 229193003313 probable transmembrane helix predicted by TMHMM2.0 229193003314 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 229193003315 ATP cone domain; Region: ATP-cone; pfam03477 229193003316 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 229193003317 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 229193003318 catalytic motif [active] 229193003319 Zn binding site [ion binding]; other site 229193003320 RibD C-terminal domain; Region: RibD_C; cl17279 229193003321 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 229193003322 homopentamer interface [polypeptide binding]; other site 229193003323 active site 229193003324 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 229193003325 putative RNA binding site [nucleotide binding]; other site 229193003326 thiamine monophosphate kinase; Provisional; Region: PRK05731 229193003327 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 229193003328 ATP binding site [chemical binding]; other site 229193003329 dimerization interface [polypeptide binding]; other site 229193003330 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 229193003331 tetramer interfaces [polypeptide binding]; other site 229193003332 binuclear metal-binding site [ion binding]; other site 229193003333 HMMPfam match to entry PF04608 PgpA, E-value 1.2e-90 229193003334 probable transmembrane helix predicted by TMHMM2.0 229193003335 probable transmembrane helix predicted by TMHMM2.0 229193003336 probable transmembrane helix predicted by TMHMM2.0 229193003337 probable transmembrane helix predicted by TMHMM2.0 229193003338 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193003339 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 229193003340 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 229193003341 TPP-binding site; other site 229193003342 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 229193003343 PYR/PP interface [polypeptide binding]; other site 229193003344 dimer interface [polypeptide binding]; other site 229193003345 TPP binding site [chemical binding]; other site 229193003346 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 229193003347 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 229193003348 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 229193003349 substrate binding pocket [chemical binding]; other site 229193003350 chain length determination region; other site 229193003351 substrate-Mg2+ binding site; other site 229193003352 catalytic residues [active] 229193003353 aspartate-rich region 1; other site 229193003354 active site lid residues [active] 229193003355 aspartate-rich region 2; other site 229193003356 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 229193003357 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 229193003358 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 229193003359 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 229193003360 Ligand Binding Site [chemical binding]; other site 229193003361 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 229193003362 active site residue [active] 229193003363 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 229193003364 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 229193003365 conserved cys residue [active] 229193003366 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 229193003367 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 229193003368 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 229193003369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 229193003370 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 229193003371 HMMPfam match to entry PF04461 DUF520, E-value 6.3e-106 229193003372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193003373 Major Facilitator Superfamily; Region: MFS_1; pfam07690 229193003374 putative substrate translocation pore; other site 229193003375 probable transmembrane helix predicted by TMHMM2.0 229193003376 probable transmembrane helix predicted by TMHMM2.0 229193003377 probable transmembrane helix predicted by TMHMM2.0 229193003378 probable transmembrane helix predicted by TMHMM2.0 229193003379 probable transmembrane helix predicted by TMHMM2.0 229193003380 probable transmembrane helix predicted by TMHMM2.0 229193003381 probable transmembrane helix predicted by TMHMM2.0 229193003382 probable transmembrane helix predicted by TMHMM2.0 229193003383 probable transmembrane helix predicted by TMHMM2.0 229193003384 probable transmembrane helix predicted by TMHMM2.0 229193003385 probable transmembrane helix predicted by TMHMM2.0 229193003386 probable transmembrane helix predicted by TMHMM2.0 229193003387 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 229193003388 UbiA prenyltransferase family; Region: UbiA; pfam01040 229193003389 probable transmembrane helix predicted by TMHMM2.0 229193003390 probable transmembrane helix predicted by TMHMM2.0 229193003391 probable transmembrane helix predicted by TMHMM2.0 229193003392 probable transmembrane helix predicted by TMHMM2.0 229193003393 probable transmembrane helix predicted by TMHMM2.0 229193003394 probable transmembrane helix predicted by TMHMM2.0 229193003395 probable transmembrane helix predicted by TMHMM2.0 229193003396 probable transmembrane helix predicted by TMHMM2.0 229193003397 probable transmembrane helix predicted by TMHMM2.0 229193003398 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 229193003399 probable transmembrane helix predicted by TMHMM2.0 229193003400 probable transmembrane helix predicted by TMHMM2.0 229193003401 probable transmembrane helix predicted by TMHMM2.0 229193003402 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 229193003403 Subunit I/III interface [polypeptide binding]; other site 229193003404 Subunit III/IV interface [polypeptide binding]; other site 229193003405 probable transmembrane helix predicted by TMHMM2.0 229193003406 probable transmembrane helix predicted by TMHMM2.0 229193003407 probable transmembrane helix predicted by TMHMM2.0 229193003408 probable transmembrane helix predicted by TMHMM2.0 229193003409 probable transmembrane helix predicted by TMHMM2.0 229193003410 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 229193003411 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 229193003412 D-pathway; other site 229193003413 Putative ubiquinol binding site [chemical binding]; other site 229193003414 Low-spin heme (heme b) binding site [chemical binding]; other site 229193003415 Putative water exit pathway; other site 229193003416 Binuclear center (heme o3/CuB) [ion binding]; other site 229193003417 K-pathway; other site 229193003418 Putative proton exit pathway; other site 229193003419 probable transmembrane helix predicted by TMHMM2.0 229193003420 probable transmembrane helix predicted by TMHMM2.0 229193003421 probable transmembrane helix predicted by TMHMM2.0 229193003422 probable transmembrane helix predicted by TMHMM2.0 229193003423 probable transmembrane helix predicted by TMHMM2.0 229193003424 probable transmembrane helix predicted by TMHMM2.0 229193003425 probable transmembrane helix predicted by TMHMM2.0 229193003426 probable transmembrane helix predicted by TMHMM2.0 229193003427 probable transmembrane helix predicted by TMHMM2.0 229193003428 probable transmembrane helix predicted by TMHMM2.0 229193003429 probable transmembrane helix predicted by TMHMM2.0 229193003430 probable transmembrane helix predicted by TMHMM2.0 229193003431 probable transmembrane helix predicted by TMHMM2.0 229193003432 probable transmembrane helix predicted by TMHMM2.0 229193003433 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 229193003434 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 229193003435 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 229193003436 probable transmembrane helix predicted by TMHMM2.0 229193003437 probable transmembrane helix predicted by TMHMM2.0 229193003438 probable transmembrane helix predicted by TMHMM2.0 229193003439 hypothetical protein; Provisional; Region: PRK11528 229193003440 muropeptide transporter; Reviewed; Region: ampG; PRK11902 229193003441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193003442 putative substrate translocation pore; other site 229193003443 probable transmembrane helix predicted by TMHMM2.0 229193003444 probable transmembrane helix predicted by TMHMM2.0 229193003445 probable transmembrane helix predicted by TMHMM2.0 229193003446 probable transmembrane helix predicted by TMHMM2.0 229193003447 probable transmembrane helix predicted by TMHMM2.0 229193003448 probable transmembrane helix predicted by TMHMM2.0 229193003449 probable transmembrane helix predicted by TMHMM2.0 229193003450 probable transmembrane helix predicted by TMHMM2.0 229193003451 probable transmembrane helix predicted by TMHMM2.0 229193003452 probable transmembrane helix predicted by TMHMM2.0 229193003453 probable transmembrane helix predicted by TMHMM2.0 229193003454 probable transmembrane helix predicted by TMHMM2.0 229193003455 probable transmembrane helix predicted by TMHMM2.0 229193003456 probable transmembrane helix predicted by TMHMM2.0 229193003457 hypothetical protein; Provisional; Region: PRK11627 229193003458 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 229193003459 probable transmembrane helix predicted by TMHMM2.0 229193003460 transcriptional regulator BolA; Provisional; Region: PRK11628 229193003461 BlastProDom match to entry PD004789 sp_P15298_BOLA_ECOLI, E-value 2e-16 229193003462 trigger factor; Provisional; Region: tig; PRK01490 229193003463 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 229193003464 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 229193003465 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 229193003466 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 229193003467 oligomer interface [polypeptide binding]; other site 229193003468 active site residues [active] 229193003469 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 229193003470 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 229193003471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193003472 Walker A motif; other site 229193003473 ATP binding site [chemical binding]; other site 229193003474 Walker B motif; other site 229193003475 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 229193003476 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 229193003477 Found in ATP-dependent protease La (LON); Region: LON; smart00464 229193003478 Found in ATP-dependent protease La (LON); Region: LON; smart00464 229193003479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193003480 Walker A motif; other site 229193003481 ATP binding site [chemical binding]; other site 229193003482 Walker B motif; other site 229193003483 arginine finger; other site 229193003484 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 229193003485 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 229193003486 IHF dimer interface [polypeptide binding]; other site 229193003487 IHF - DNA interface [nucleotide binding]; other site 229193003488 periplasmic folding chaperone; Provisional; Region: PRK10788 229193003489 SurA N-terminal domain; Region: SurA_N_3; cl07813 229193003490 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 229193003491 probable transmembrane helix predicted by TMHMM2.0 229193003492 BlastProDom match to entry PD002510 sp_P77241_PPID_ECOLI, E-value 3e-25 229193003493 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 229193003494 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 229193003495 BlastProDom match to entry PD006092 sp_P77415_YBAV_ECOLI, E-value 5e-12 229193003496 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 229193003497 active site 229193003498 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 229193003499 Ligand Binding Site [chemical binding]; other site 229193003500 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 229193003501 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 229193003502 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 229193003503 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 229193003504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193003505 active site 229193003506 motif I; other site 229193003507 motif II; other site 229193003508 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 229193003509 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 229193003510 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193003511 catalytic residue [active] 229193003512 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 229193003513 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 229193003514 putative DNA binding site [nucleotide binding]; other site 229193003515 putative Zn2+ binding site [ion binding]; other site 229193003516 AsnC family; Region: AsnC_trans_reg; pfam01037 229193003517 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 229193003518 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 229193003519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193003520 Walker A/P-loop; other site 229193003521 ATP binding site [chemical binding]; other site 229193003522 Q-loop/lid; other site 229193003523 ABC transporter signature motif; other site 229193003524 Walker B; other site 229193003525 D-loop; other site 229193003526 H-loop/switch region; other site 229193003527 probable transmembrane helix predicted by TMHMM2.0 229193003528 probable transmembrane helix predicted by TMHMM2.0 229193003529 probable transmembrane helix predicted by TMHMM2.0 229193003530 probable transmembrane helix predicted by TMHMM2.0 229193003531 probable transmembrane helix predicted by TMHMM2.0 229193003532 probable transmembrane helix predicted by TMHMM2.0 229193003533 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 229193003534 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 229193003535 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 229193003536 Walker A/P-loop; other site 229193003537 ATP binding site [chemical binding]; other site 229193003538 Q-loop/lid; other site 229193003539 ABC transporter signature motif; other site 229193003540 Walker B; other site 229193003541 D-loop; other site 229193003542 H-loop/switch region; other site 229193003543 probable transmembrane helix predicted by TMHMM2.0 229193003544 probable transmembrane helix predicted by TMHMM2.0 229193003545 probable transmembrane helix predicted by TMHMM2.0 229193003546 probable transmembrane helix predicted by TMHMM2.0 229193003547 probable transmembrane helix predicted by TMHMM2.0 229193003548 Nitrogen regulatory protein P-II; Region: P-II; cl00412 229193003549 Nitrogen regulatory protein P-II; Region: P-II; smart00938 229193003550 ammonium transporter; Provisional; Region: PRK10666 229193003551 probable transmembrane helix predicted by TMHMM2.0 229193003552 probable transmembrane helix predicted by TMHMM2.0 229193003553 probable transmembrane helix predicted by TMHMM2.0 229193003554 probable transmembrane helix predicted by TMHMM2.0 229193003555 probable transmembrane helix predicted by TMHMM2.0 229193003556 probable transmembrane helix predicted by TMHMM2.0 229193003557 probable transmembrane helix predicted by TMHMM2.0 229193003558 probable transmembrane helix predicted by TMHMM2.0 229193003559 probable transmembrane helix predicted by TMHMM2.0 229193003560 probable transmembrane helix predicted by TMHMM2.0 229193003561 probable transmembrane helix predicted by TMHMM2.0 229193003562 probable transmembrane helix predicted by TMHMM2.0 229193003563 acyl-CoA thioesterase II; Provisional; Region: PRK10526 229193003564 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 229193003565 active site 229193003566 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 229193003567 catalytic triad [active] 229193003568 dimer interface [polypeptide binding]; other site 229193003569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 229193003570 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 229193003571 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 229193003572 DNA binding site [nucleotide binding] 229193003573 active site 229193003574 gene expression modulator; Provisional; Region: PRK10945 229193003575 Hha toxicity attenuator; Provisional; Region: PRK10667 229193003576 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 229193003577 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 229193003578 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 229193003579 Protein export membrane protein; Region: SecD_SecF; cl14618 229193003580 probable transmembrane helix predicted by TMHMM2.0 229193003581 probable transmembrane helix predicted by TMHMM2.0 229193003582 probable transmembrane helix predicted by TMHMM2.0 229193003583 probable transmembrane helix predicted by TMHMM2.0 229193003584 probable transmembrane helix predicted by TMHMM2.0 229193003585 probable transmembrane helix predicted by TMHMM2.0 229193003586 probable transmembrane helix predicted by TMHMM2.0 229193003587 probable transmembrane helix predicted by TMHMM2.0 229193003588 probable transmembrane helix predicted by TMHMM2.0 229193003589 probable transmembrane helix predicted by TMHMM2.0 229193003590 probable transmembrane helix predicted by TMHMM2.0 229193003591 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 229193003592 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 229193003593 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193003594 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 229193003595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 229193003596 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 229193003597 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 229193003598 hypothetical protein; Provisional; Region: PRK11281 229193003599 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 229193003600 Mechanosensitive ion channel; Region: MS_channel; pfam00924 229193003601 probable transmembrane helix predicted by TMHMM2.0 229193003602 probable transmembrane helix predicted by TMHMM2.0 229193003603 probable transmembrane helix predicted by TMHMM2.0 229193003604 probable transmembrane helix predicted by TMHMM2.0 229193003605 probable transmembrane helix predicted by TMHMM2.0 229193003606 probable transmembrane helix predicted by TMHMM2.0 229193003607 probable transmembrane helix predicted by TMHMM2.0 229193003608 probable transmembrane helix predicted by TMHMM2.0 229193003609 probable transmembrane helix predicted by TMHMM2.0 229193003610 probable transmembrane helix predicted by TMHMM2.0 229193003611 probable transmembrane helix predicted by TMHMM2.0 229193003612 probable transmembrane helix predicted by TMHMM2.0 229193003613 hypothetical protein; Provisional; Region: PRK11038 229193003614 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 229193003615 hypothetical protein; Provisional; Region: PRK10527 229193003616 probable transmembrane helix predicted by TMHMM2.0 229193003617 HMMPfam match to entry PF04304 DUF454, E-value 3.7e-23 229193003618 probable transmembrane helix predicted by TMHMM2.0 229193003619 probable transmembrane helix predicted by TMHMM2.0 229193003620 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 229193003621 active site 229193003622 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 229193003623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193003624 Walker A motif; other site 229193003625 ATP binding site [chemical binding]; other site 229193003626 Walker B motif; other site 229193003627 arginine finger; other site 229193003628 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 229193003629 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 229193003630 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 229193003631 hypothetical protein; Validated; Region: PRK00153 229193003632 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 229193003633 RecR protein; Region: RecR; pfam02132 229193003634 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 229193003635 putative active site [active] 229193003636 putative metal-binding site [ion binding]; other site 229193003637 tetramer interface [polypeptide binding]; other site 229193003638 heat shock protein 90; Provisional; Region: PRK05218 229193003639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193003640 ATP binding site [chemical binding]; other site 229193003641 Mg2+ binding site [ion binding]; other site 229193003642 G-X-G motif; other site 229193003643 adenylate kinase; Reviewed; Region: adk; PRK00279 229193003644 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 229193003645 AMP-binding site [chemical binding]; other site 229193003646 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 229193003647 HMMPfam match to entry PF05191 ADK_lid, E-value 1.8e-19 229193003648 ferrochelatase; Reviewed; Region: hemH; PRK00035 229193003649 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 229193003650 C-terminal domain interface [polypeptide binding]; other site 229193003651 active site 229193003652 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 229193003653 active site 229193003654 N-terminal domain interface [polypeptide binding]; other site 229193003655 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 229193003656 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 229193003657 catalytic loop [active] 229193003658 iron binding site [ion binding]; other site 229193003659 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 229193003660 FAD binding pocket [chemical binding]; other site 229193003661 FAD binding motif [chemical binding]; other site 229193003662 phosphate binding motif [ion binding]; other site 229193003663 beta-alpha-beta structure motif; other site 229193003664 NAD binding pocket [chemical binding]; other site 229193003665 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 229193003666 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 229193003667 substrate binding site; other site 229193003668 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 229193003669 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 229193003670 NAD binding site [chemical binding]; other site 229193003671 homotetramer interface [polypeptide binding]; other site 229193003672 homodimer interface [polypeptide binding]; other site 229193003673 substrate binding site [chemical binding]; other site 229193003674 active site 229193003675 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 229193003676 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 229193003677 inhibitor-cofactor binding pocket; inhibition site 229193003678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193003679 catalytic residue [active] 229193003680 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 229193003681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 229193003682 NAD(P) binding site [chemical binding]; other site 229193003683 active site 229193003684 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 229193003685 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 229193003686 Contains Glycosyl transferase, family 2 (Interpro|IPR001173) 229193003687 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 229193003688 probable transmembrane helix predicted by TMHMM2.0 229193003689 probable transmembrane helix predicted by TMHMM2.0 229193003690 probable transmembrane helix predicted by TMHMM2.0 229193003691 probable transmembrane helix predicted by TMHMM2.0 229193003692 probable transmembrane helix predicted by TMHMM2.0 229193003693 probable transmembrane helix predicted by TMHMM2.0 229193003694 probable transmembrane helix predicted by TMHMM2.0 229193003695 probable transmembrane helix predicted by TMHMM2.0 229193003696 probable transmembrane helix predicted by TMHMM2.0 229193003697 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 229193003698 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 229193003699 probable transmembrane helix predicted by TMHMM2.0 229193003700 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 229193003701 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 229193003702 NADP binding site [chemical binding]; other site 229193003703 active site 229193003704 putative substrate binding site [chemical binding]; other site 229193003705 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 229193003706 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 229193003707 metal-binding site 229193003708 phosphomannomutase CpsG; Provisional; Region: PRK15414 229193003709 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 229193003710 active site 229193003711 substrate binding site [chemical binding]; other site 229193003712 metal binding site [ion binding]; metal-binding site 229193003713 LPS O-antigen length regulator; Provisional; Region: PRK10381 229193003714 Chain length determinant protein; Region: Wzz; pfam02706 229193003715 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 229193003716 probable transmembrane helix predicted by TMHMM2.0 229193003717 probable transmembrane helix predicted by TMHMM2.0 229193003718 inosine/guanosine kinase; Provisional; Region: PRK15074 229193003719 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 229193003720 substrate binding site [chemical binding]; other site 229193003721 ATP binding site [chemical binding]; other site 229193003722 BlastProDom match to entry PD022382 sp_Q56875_Q56875_YEREN, E-value 0.0 229193003723 putative cation:proton antiport protein; Provisional; Region: PRK10669 229193003724 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 229193003725 TrkA-N domain; Region: TrkA_N; pfam02254 229193003726 probable transmembrane helix predicted by TMHMM2.0 229193003727 probable transmembrane helix predicted by TMHMM2.0 229193003728 probable transmembrane helix predicted by TMHMM2.0 229193003729 probable transmembrane helix predicted by TMHMM2.0 229193003730 probable transmembrane helix predicted by TMHMM2.0 229193003731 probable transmembrane helix predicted by TMHMM2.0 229193003732 probable transmembrane helix predicted by TMHMM2.0 229193003733 probable transmembrane helix predicted by TMHMM2.0 229193003734 probable transmembrane helix predicted by TMHMM2.0 229193003735 probable transmembrane helix predicted by TMHMM2.0 229193003736 probable transmembrane helix predicted by TMHMM2.0 229193003737 probable transmembrane helix predicted by TMHMM2.0 229193003738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193003739 Major Facilitator Superfamily; Region: MFS_1; pfam07690 229193003740 putative substrate translocation pore; other site 229193003741 probable transmembrane helix predicted by TMHMM2.0 229193003742 probable transmembrane helix predicted by TMHMM2.0 229193003743 probable transmembrane helix predicted by TMHMM2.0 229193003744 probable transmembrane helix predicted by TMHMM2.0 229193003745 probable transmembrane helix predicted by TMHMM2.0 229193003746 probable transmembrane helix predicted by TMHMM2.0 229193003747 probable transmembrane helix predicted by TMHMM2.0 229193003748 probable transmembrane helix predicted by TMHMM2.0 229193003749 probable transmembrane helix predicted by TMHMM2.0 229193003750 probable transmembrane helix predicted by TMHMM2.0 229193003751 Contains 5'-nucleotidase, N-terminal (Interpro|IPR006146, (GO:0009166), (GO:0016788)) . Contains 5'-nucleotidase, N-terminal (Interpro|IPR006146, (GO:0009166), (GO:0016788)). Contains 5'-nucleotidase, N-terminal (Interpro|IPR006146, (GO:0009166), (GO:0016788)). Contains 5'-Nucleotidase and apyrase (Interpro|IPR006179, (GO:0009166), (GO:0016787)). Contains 5'-Nucleotidase and apyrase (Interpro|IPR006179, (GO:0009166), (GO:0016787)) 229193003752 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 229193003753 putative deacylase active site [active] 229193003754 HMMPfam match to entry PF04073 YbaK, E-value 1.1e-70 229193003755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 229193003756 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 229193003757 metal-binding site [ion binding] 229193003758 copper exporting ATPase; Provisional; Region: copA; PRK10671 229193003759 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 229193003760 metal-binding site [ion binding] 229193003761 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 229193003762 metal-binding site [ion binding] 229193003763 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 229193003764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193003765 motif II; other site 229193003766 probable transmembrane helix predicted by TMHMM2.0 229193003767 probable transmembrane helix predicted by TMHMM2.0 229193003768 probable transmembrane helix predicted by TMHMM2.0 229193003769 probable transmembrane helix predicted by TMHMM2.0 229193003770 probable transmembrane helix predicted by TMHMM2.0 229193003771 probable transmembrane helix predicted by TMHMM2.0 229193003772 probable transmembrane helix predicted by TMHMM2.0 229193003773 probable transmembrane helix predicted by TMHMM2.0 229193003774 ProfileScan match to entry PS50325 THR_RICH, E-value 9.748 229193003775 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 229193003776 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 229193003777 DNA binding residues [nucleotide binding] 229193003778 dimer interface [polypeptide binding]; other site 229193003779 copper binding site [ion binding]; other site 229193003780 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 229193003781 probable transmembrane helix predicted by TMHMM2.0 229193003782 probable transmembrane helix predicted by TMHMM2.0 229193003783 probable transmembrane helix predicted by TMHMM2.0 229193003784 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 229193003785 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 229193003786 probable transmembrane helix predicted by TMHMM2.0 229193003787 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 229193003788 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 229193003789 BlastProDom match to entry PD037267 sp_P77395_YBBN_ECOLI, E-value 4e-34 229193003790 oxidoreductase; Provisional; Region: PRK08017 229193003791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 229193003792 NAD(P) binding site [chemical binding]; other site 229193003793 active site 229193003794 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 229193003795 active site 229193003796 catalytic triad [active] 229193003797 oxyanion hole [active] 229193003798 switch loop; other site 229193003799 BlastProDom match to entry PD036745 sp_P29679_TESA_ECOLI, E-value 3e-64 229193003800 probable transmembrane helix predicted by TMHMM2.0 229193003801 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 229193003802 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 229193003803 Walker A/P-loop; other site 229193003804 ATP binding site [chemical binding]; other site 229193003805 Q-loop/lid; other site 229193003806 ABC transporter signature motif; other site 229193003807 Walker B; other site 229193003808 D-loop; other site 229193003809 H-loop/switch region; other site 229193003810 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 229193003811 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 229193003812 FtsX-like permease family; Region: FtsX; pfam02687 229193003813 probable transmembrane helix predicted by TMHMM2.0 229193003814 probable transmembrane helix predicted by TMHMM2.0 229193003815 ProfileScan match to entry PS50319 LEU_RICH, E-value 16.757 229193003816 probable transmembrane helix predicted by TMHMM2.0 229193003817 probable transmembrane helix predicted by TMHMM2.0 229193003818 probable transmembrane helix predicted by TMHMM2.0 229193003819 probable transmembrane helix predicted by TMHMM2.0 229193003820 probable transmembrane helix predicted by TMHMM2.0 229193003821 probable transmembrane helix predicted by TMHMM2.0 229193003822 probable transmembrane helix predicted by TMHMM2.0 229193003823 probable transmembrane helix predicted by TMHMM2.0 229193003824 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 229193003825 ATP-grasp domain; Region: ATP-grasp; pfam02222 229193003826 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 229193003827 probable transmembrane helix predicted by TMHMM2.0 229193003828 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 229193003829 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 229193003830 putative active site [active] 229193003831 putative metal binding site [ion binding]; other site 229193003832 BlastProDom match to entry PD038423 sp_P43341_LPXH_ECOLI, E-value 9e-84 229193003833 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 229193003834 substrate binding site [chemical binding]; other site 229193003835 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 229193003836 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 229193003837 active site 229193003838 HIGH motif; other site 229193003839 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 229193003840 KMSKS motif; other site 229193003841 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 229193003842 tRNA binding surface [nucleotide binding]; other site 229193003843 anticodon binding site; other site 229193003844 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193003845 ribosome-associated protein; Provisional; Region: PRK11507 229193003846 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 229193003847 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 229193003848 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 229193003849 homodimer interface [polypeptide binding]; other site 229193003850 NADP binding site [chemical binding]; other site 229193003851 substrate binding site [chemical binding]; other site 229193003852 probable transmembrane helix predicted by TMHMM2.0 229193003853 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 229193003854 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 229193003855 probable transmembrane helix predicted by TMHMM2.0 229193003856 probable transmembrane helix predicted by TMHMM2.0 229193003857 probable transmembrane helix predicted by TMHMM2.0 229193003858 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 229193003859 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 229193003860 probable transmembrane helix predicted by TMHMM2.0 229193003861 probable transmembrane helix predicted by TMHMM2.0 229193003862 probable transmembrane helix predicted by TMHMM2.0 229193003863 probable transmembrane helix predicted by TMHMM2.0 229193003864 probable transmembrane helix predicted by TMHMM2.0 229193003865 probable transmembrane helix predicted by TMHMM2.0 229193003866 probable transmembrane helix predicted by TMHMM2.0 229193003867 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 229193003868 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 229193003869 putative acyl-acceptor binding pocket; other site 229193003870 probable transmembrane helix predicted by TMHMM2.0 229193003871 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 229193003872 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 229193003873 Putative methyltransferase; Region: Methyltransf_20; pfam12147 229193003874 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 229193003875 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 229193003876 active site 229193003877 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 229193003878 active site 229193003879 catalytic residues [active] 229193003880 probable transmembrane helix predicted by TMHMM2.0 229193003881 probable transmembrane helix predicted by TMHMM2.0 229193003882 probable transmembrane helix predicted by TMHMM2.0 229193003883 probable transmembrane helix predicted by TMHMM2.0 229193003884 probable transmembrane helix predicted by TMHMM2.0 229193003885 probable transmembrane helix predicted by TMHMM2.0 229193003886 probable transmembrane helix predicted by TMHMM2.0 229193003887 probable transmembrane helix predicted by TMHMM2.0 229193003888 probable transmembrane helix predicted by TMHMM2.0 229193003889 probable transmembrane helix predicted by TMHMM2.0 229193003890 transposase/IS protein; Provisional; Region: PRK09183 229193003891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193003892 Walker A motif; other site 229193003893 ATP binding site [chemical binding]; other site 229193003894 Walker B motif; other site 229193003895 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193003896 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193003897 DNA-binding interface [nucleotide binding]; DNA binding site 229193003898 Integrase core domain; Region: rve; pfam00665 229193003899 probable transmembrane helix predicted by TMHMM2.0 229193003900 probable transmembrane helix predicted by TMHMM2.0 229193003901 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 229193003902 active site 2 [active] 229193003903 dimer interface [polypeptide binding]; other site 229193003904 active site 1 [active] 229193003905 BlastProDom match to entry PD013327 sp_P18391_FABA_ECOLI, E-value 1e-70 229193003906 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 229193003907 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 229193003908 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 229193003909 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193003910 Nucleoid-associated protein [General function prediction only]; Region: COG3081 229193003911 nucleoid-associated protein NdpA; Validated; Region: PRK00378 229193003912 HMMPfam match to entry PF04245 NA37, E-value 1.1e-173 229193003913 hypothetical protein; Provisional; Region: PRK13689 229193003914 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 229193003915 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 229193003916 Sulfatase; Region: Sulfatase; cl17466 229193003917 probable transmembrane helix predicted by TMHMM2.0 229193003918 probable transmembrane helix predicted by TMHMM2.0 229193003919 probable transmembrane helix predicted by TMHMM2.0 229193003920 probable transmembrane helix predicted by TMHMM2.0 229193003921 probable transmembrane helix predicted by TMHMM2.0 229193003922 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 229193003923 active site 229193003924 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 229193003925 beta-galactosidase; Region: BGL; TIGR03356 229193003926 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 229193003927 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 229193003928 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 229193003929 putative active site [active] 229193003930 Phage Tail Collar Domain; Region: Collar; pfam07484 229193003931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 229193003932 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 229193003933 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 229193003934 Mu-like prophage protein gp46 [Function unknown]; Region: COG4381 229193003935 Mu-like prophage protein gp45 [Function unknown]; Region: COG4384 229193003936 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 229193003937 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 229193003938 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 229193003939 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 229193003940 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 229193003941 Phage tail tube protein; Region: Tail_tube; pfam10618 229193003942 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 229193003943 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 229193003944 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 229193003945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 229193003946 probable transmembrane helix predicted by TMHMM2.0 229193003947 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 229193003948 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 229193003949 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 229193003950 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 229193003951 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 229193003952 putative aldolase; Validated; Region: PRK08130 229193003953 intersubunit interface [polypeptide binding]; other site 229193003954 active site 229193003955 Zn2+ binding site [ion binding]; other site 229193003956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 229193003957 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 229193003958 BlastProDom match to entry PD031922 sp_Q9T1U3_REGQ_BPAPS, E-value 3e-23 229193003959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 229193003960 non-specific DNA binding site [nucleotide binding]; other site 229193003961 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 229193003962 salt bridge; other site 229193003963 sequence-specific DNA binding site [nucleotide binding]; other site 229193003964 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 229193003965 Catalytic site [active] 229193003966 DinI-like family; Region: DinI; cl11630 229193003967 Outer membrane protease [Cell envelope biogenesis, outer membrane]; Region: OmpT; COG4571 229193003968 Cache domain; Region: Cache_1; pfam02743 229193003969 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 229193003970 dimerization interface [polypeptide binding]; other site 229193003971 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 229193003972 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 229193003973 dimer interface [polypeptide binding]; other site 229193003974 putative CheW interface [polypeptide binding]; other site 229193003975 probable transmembrane helix predicted by TMHMM2.0 229193003976 probable transmembrane helix predicted by TMHMM2.0 229193003977 BlastProDom match to entry PD000571 sp_P07018_MCP4_ECOLI, E-value 1e-09 229193003978 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 229193003979 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 229193003980 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 229193003981 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 229193003982 probable transmembrane helix predicted by TMHMM2.0 229193003983 probable transmembrane helix predicted by TMHMM2.0 229193003984 probable transmembrane helix predicted by TMHMM2.0 229193003985 probable transmembrane helix predicted by TMHMM2.0 229193003986 probable transmembrane helix predicted by TMHMM2.0 229193003987 probable transmembrane helix predicted by TMHMM2.0 229193003988 probable transmembrane helix predicted by TMHMM2.0 229193003989 probable transmembrane helix predicted by TMHMM2.0 229193003990 probable transmembrane helix predicted by TMHMM2.0 229193003991 probable transmembrane helix predicted by TMHMM2.0 229193003992 probable transmembrane helix predicted by TMHMM2.0 229193003993 probable transmembrane helix predicted by TMHMM2.0 229193003994 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 229193003995 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 229193003996 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 229193003997 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 229193003998 trimer interface [polypeptide binding]; other site 229193003999 eyelet of channel; other site 229193004000 probable transmembrane helix predicted by TMHMM2.0 229193004001 probable transmembrane helix predicted by TMHMM2.0 229193004002 probable transmembrane helix predicted by TMHMM2.0 229193004003 probable transmembrane helix predicted by TMHMM2.0 229193004004 probable transmembrane helix predicted by TMHMM2.0 229193004005 probable transmembrane helix predicted by TMHMM2.0 229193004006 probable transmembrane helix predicted by TMHMM2.0 229193004007 probable transmembrane helix predicted by TMHMM2.0 229193004008 probable transmembrane helix predicted by TMHMM2.0 229193004009 probable transmembrane helix predicted by TMHMM2.0 229193004010 probable transmembrane helix predicted by TMHMM2.0 229193004011 probable transmembrane helix predicted by TMHMM2.0 229193004012 transcriptional regulator RcsB; Provisional; Region: PRK10840 229193004013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193004014 active site 229193004015 phosphorylation site [posttranslational modification] 229193004016 intermolecular recognition site; other site 229193004017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193004018 DNA binding residues [nucleotide binding] 229193004019 dimerization interface [polypeptide binding]; other site 229193004020 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 229193004021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193004022 dimer interface [polypeptide binding]; other site 229193004023 phosphorylation site [posttranslational modification] 229193004024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193004025 ATP binding site [chemical binding]; other site 229193004026 Mg2+ binding site [ion binding]; other site 229193004027 G-X-G motif; other site 229193004028 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 229193004029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193004030 active site 229193004031 phosphorylation site [posttranslational modification] 229193004032 intermolecular recognition site; other site 229193004033 dimerization interface [polypeptide binding]; other site 229193004034 probable transmembrane helix predicted by TMHMM2.0 229193004035 probable transmembrane helix predicted by TMHMM2.0 229193004036 DNA gyrase subunit A; Validated; Region: PRK05560 229193004037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 229193004038 CAP-like domain; other site 229193004039 active site 229193004040 primary dimer interface [polypeptide binding]; other site 229193004041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 229193004042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 229193004043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 229193004044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 229193004045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 229193004046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 229193004047 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 229193004048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193004049 S-adenosylmethionine binding site [chemical binding]; other site 229193004050 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 229193004051 ATP cone domain; Region: ATP-cone; pfam03477 229193004052 Class I ribonucleotide reductase; Region: RNR_I; cd01679 229193004053 active site 229193004054 dimer interface [polypeptide binding]; other site 229193004055 catalytic residues [active] 229193004056 effector binding site; other site 229193004057 R2 peptide binding site; other site 229193004058 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 229193004059 dimer interface [polypeptide binding]; other site 229193004060 putative radical transfer pathway; other site 229193004061 diiron center [ion binding]; other site 229193004062 tyrosyl radical; other site 229193004063 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 229193004064 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 229193004065 catalytic loop [active] 229193004066 iron binding site [ion binding]; other site 229193004067 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 229193004068 secondary substrate binding site; other site 229193004069 primary substrate binding site; other site 229193004070 inhibition loop; other site 229193004071 dimerization interface [polypeptide binding]; other site 229193004072 probable transmembrane helix predicted by TMHMM2.0 229193004073 hypothetical protein; Provisional; Region: PRK03673 229193004074 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 229193004075 putative MPT binding site; other site 229193004076 Competence-damaged protein; Region: CinA; cl00666 229193004077 tyrosine transporter TyrP; Provisional; Region: PRK15132 229193004078 aromatic amino acid transport protein; Region: araaP; TIGR00837 229193004079 probable transmembrane helix predicted by TMHMM2.0 229193004080 BlastProDom match to entry PD007729 sp_P18199_TYRP_ECOLI, E-value e-132 229193004081 probable transmembrane helix predicted by TMHMM2.0 229193004082 probable transmembrane helix predicted by TMHMM2.0 229193004083 probable transmembrane helix predicted by TMHMM2.0 229193004084 probable transmembrane helix predicted by TMHMM2.0 229193004085 probable transmembrane helix predicted by TMHMM2.0 229193004086 probable transmembrane helix predicted by TMHMM2.0 229193004087 probable transmembrane helix predicted by TMHMM2.0 229193004088 probable transmembrane helix predicted by TMHMM2.0 229193004089 probable transmembrane helix predicted by TMHMM2.0 229193004090 probable transmembrane helix predicted by TMHMM2.0 229193004091 YfaZ precursor; Region: YfaZ; pfam07437 229193004092 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 229193004093 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 229193004094 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 229193004095 tetramer interface [polypeptide binding]; other site 229193004096 heme binding pocket [chemical binding]; other site 229193004097 NADPH binding site [chemical binding]; other site 229193004098 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 229193004099 DEAD_2; Region: DEAD_2; pfam06733 229193004100 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 229193004101 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 229193004102 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 229193004103 trimer interface [polypeptide binding]; other site 229193004104 eyelet of channel; other site 229193004105 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 229193004106 EamA-like transporter family; Region: EamA; pfam00892 229193004107 EamA-like transporter family; Region: EamA; pfam00892 229193004108 probable transmembrane helix predicted by TMHMM2.0 229193004109 probable transmembrane helix predicted by TMHMM2.0 229193004110 probable transmembrane helix predicted by TMHMM2.0 229193004111 probable transmembrane helix predicted by TMHMM2.0 229193004112 probable transmembrane helix predicted by TMHMM2.0 229193004113 probable transmembrane helix predicted by TMHMM2.0 229193004114 probable transmembrane helix predicted by TMHMM2.0 229193004115 probable transmembrane helix predicted by TMHMM2.0 229193004116 probable transmembrane helix predicted by TMHMM2.0 229193004117 probable transmembrane helix predicted by TMHMM2.0 229193004118 probable transmembrane helix predicted by TMHMM2.0 229193004119 arginine decarboxylase; Provisional; Region: PRK15029 229193004120 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 229193004121 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 229193004122 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193004123 catalytic residue [active] 229193004124 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 229193004125 arginine:agmatin antiporter; Provisional; Region: PRK10644 229193004126 Spore germination protein; Region: Spore_permease; cl17796 229193004127 probable transmembrane helix predicted by TMHMM2.0 229193004128 probable transmembrane helix predicted by TMHMM2.0 229193004129 probable transmembrane helix predicted by TMHMM2.0 229193004130 probable transmembrane helix predicted by TMHMM2.0 229193004131 probable transmembrane helix predicted by TMHMM2.0 229193004132 probable transmembrane helix predicted by TMHMM2.0 229193004133 probable transmembrane helix predicted by TMHMM2.0 229193004134 probable transmembrane helix predicted by TMHMM2.0 229193004135 probable transmembrane helix predicted by TMHMM2.0 229193004136 probable transmembrane helix predicted by TMHMM2.0 229193004137 probable transmembrane helix predicted by TMHMM2.0 229193004138 probable transmembrane helix predicted by TMHMM2.0 229193004139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193004140 putative PBP binding loops; other site 229193004141 dimer interface [polypeptide binding]; other site 229193004142 ABC-ATPase subunit interface; other site 229193004143 probable transmembrane helix predicted by TMHMM2.0 229193004144 probable transmembrane helix predicted by TMHMM2.0 229193004145 probable transmembrane helix predicted by TMHMM2.0 229193004146 probable transmembrane helix predicted by TMHMM2.0 229193004147 probable transmembrane helix predicted by TMHMM2.0 229193004148 probable transmembrane helix predicted by TMHMM2.0 229193004149 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 229193004150 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 229193004151 Walker A/P-loop; other site 229193004152 ATP binding site [chemical binding]; other site 229193004153 Q-loop/lid; other site 229193004154 ABC transporter signature motif; other site 229193004155 Walker B; other site 229193004156 D-loop; other site 229193004157 H-loop/switch region; other site 229193004158 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 229193004159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193004160 dimer interface [polypeptide binding]; other site 229193004161 conserved gate region; other site 229193004162 ABC-ATPase subunit interface; other site 229193004163 probable transmembrane helix predicted by TMHMM2.0 229193004164 probable transmembrane helix predicted by TMHMM2.0 229193004165 probable transmembrane helix predicted by TMHMM2.0 229193004166 probable transmembrane helix predicted by TMHMM2.0 229193004167 probable transmembrane helix predicted by TMHMM2.0 229193004168 probable transmembrane helix predicted by TMHMM2.0 229193004169 probable transmembrane helix predicted by TMHMM2.0 229193004170 probable transmembrane helix predicted by TMHMM2.0 229193004171 probable transmembrane helix predicted by TMHMM2.0 229193004172 probable transmembrane helix predicted by TMHMM2.0 229193004173 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 229193004174 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 229193004175 active site residue [active] 229193004176 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 229193004177 active site residue [active] 229193004178 tyrosine decarboxylase; Region: PLN02880 229193004179 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 229193004180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193004181 catalytic residue [active] 229193004182 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 229193004183 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 229193004184 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 229193004185 Walker A/P-loop; other site 229193004186 ATP binding site [chemical binding]; other site 229193004187 Q-loop/lid; other site 229193004188 ABC transporter signature motif; other site 229193004189 Walker B; other site 229193004190 D-loop; other site 229193004191 H-loop/switch region; other site 229193004192 Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674 229193004193 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 229193004194 Walker A/P-loop; other site 229193004195 ATP binding site [chemical binding]; other site 229193004196 Q-loop/lid; other site 229193004197 ABC transporter signature motif; other site 229193004198 Walker B; other site 229193004199 D-loop; other site 229193004200 H-loop/switch region; other site 229193004201 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 229193004202 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 229193004203 TM-ABC transporter signature motif; other site 229193004204 probable transmembrane helix predicted by TMHMM2.0 229193004205 probable transmembrane helix predicted by TMHMM2.0 229193004206 probable transmembrane helix predicted by TMHMM2.0 229193004207 probable transmembrane helix predicted by TMHMM2.0 229193004208 probable transmembrane helix predicted by TMHMM2.0 229193004209 probable transmembrane helix predicted by TMHMM2.0 229193004210 probable transmembrane helix predicted by TMHMM2.0 229193004211 probable transmembrane helix predicted by TMHMM2.0 229193004212 probable transmembrane helix predicted by TMHMM2.0 229193004213 probable transmembrane helix predicted by TMHMM2.0 229193004214 HEAT repeats; Region: HEAT_2; pfam13646 229193004215 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 229193004216 TM-ABC transporter signature motif; other site 229193004217 probable transmembrane helix predicted by TMHMM2.0 229193004218 probable transmembrane helix predicted by TMHMM2.0 229193004219 probable transmembrane helix predicted by TMHMM2.0 229193004220 probable transmembrane helix predicted by TMHMM2.0 229193004221 probable transmembrane helix predicted by TMHMM2.0 229193004222 probable transmembrane helix predicted by TMHMM2.0 229193004223 probable transmembrane helix predicted by TMHMM2.0 229193004224 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 229193004225 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 229193004226 putative ligand binding site [chemical binding]; other site 229193004227 probable transmembrane helix predicted by TMHMM2.0 229193004228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 229193004229 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 229193004230 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 229193004231 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 229193004232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193004233 dimer interface [polypeptide binding]; other site 229193004234 conserved gate region; other site 229193004235 putative PBP binding loops; other site 229193004236 ABC-ATPase subunit interface; other site 229193004237 probable transmembrane helix predicted by TMHMM2.0 229193004238 probable transmembrane helix predicted by TMHMM2.0 229193004239 probable transmembrane helix predicted by TMHMM2.0 229193004240 probable transmembrane helix predicted by TMHMM2.0 229193004241 probable transmembrane helix predicted by TMHMM2.0 229193004242 probable transmembrane helix predicted by TMHMM2.0 229193004243 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 229193004244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193004245 dimer interface [polypeptide binding]; other site 229193004246 conserved gate region; other site 229193004247 putative PBP binding loops; other site 229193004248 ABC-ATPase subunit interface; other site 229193004249 probable transmembrane helix predicted by TMHMM2.0 229193004250 probable transmembrane helix predicted by TMHMM2.0 229193004251 probable transmembrane helix predicted by TMHMM2.0 229193004252 probable transmembrane helix predicted by TMHMM2.0 229193004253 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 229193004254 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 229193004255 Transferrin; Region: Transferrin; cl02460 229193004256 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 229193004257 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 229193004258 Walker A/P-loop; other site 229193004259 ATP binding site [chemical binding]; other site 229193004260 Q-loop/lid; other site 229193004261 ABC transporter signature motif; other site 229193004262 Walker B; other site 229193004263 D-loop; other site 229193004264 H-loop/switch region; other site 229193004265 hypothetical protein; Provisional; Region: PRK10457 229193004266 HMMPfam match to entry PF04226 Transgly_assoc, E-value 6.2e-18 229193004267 probable transmembrane helix predicted by TMHMM2.0 229193004268 probable transmembrane helix predicted by TMHMM2.0 229193004269 probable transmembrane helix predicted by TMHMM2.0 229193004270 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 229193004271 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 229193004272 active site 229193004273 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 229193004274 putative active site [active] 229193004275 putative metal binding residues [ion binding]; other site 229193004276 signature motif; other site 229193004277 putative triphosphate binding site [ion binding]; other site 229193004278 dimer interface [polypeptide binding]; other site 229193004279 D-lactate dehydrogenase; Provisional; Region: PRK11183 229193004280 FAD binding domain; Region: FAD_binding_4; pfam01565 229193004281 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 229193004282 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 229193004283 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 229193004284 probable transmembrane helix predicted by TMHMM2.0 229193004285 probable transmembrane helix predicted by TMHMM2.0 229193004286 probable transmembrane helix predicted by TMHMM2.0 229193004287 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 229193004288 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 229193004289 FMN binding site [chemical binding]; other site 229193004290 active site 229193004291 catalytic residues [active] 229193004292 substrate binding site [chemical binding]; other site 229193004293 Uncharacterized conserved protein [Function unknown]; Region: COG3595 229193004294 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 229193004295 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193004296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193004297 MULE transposase domain; Region: MULE; pfam10551 229193004298 ProfileScan match to entry PS50315 GLY_RICH, E-value 26.589 229193004299 ProfileScan match to entry PS50320 MET_RICH, E-value 9.026 229193004300 probable transmembrane helix predicted by TMHMM2.0 229193004301 ProfileScan match to entry PS50315 GLY_RICH, E-value 26.452 229193004302 probable transmembrane helix predicted by TMHMM2.0 229193004303 DDE superfamily endonuclease; Region: DDE_3; pfam13358 229193004304 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 229193004305 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 229193004306 ATP binding site [chemical binding]; other site 229193004307 Mg++ binding site [ion binding]; other site 229193004308 motif III; other site 229193004309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193004310 nucleotide binding region [chemical binding]; other site 229193004311 ATP-binding site [chemical binding]; other site 229193004312 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 229193004313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 229193004314 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 229193004315 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 229193004316 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 229193004317 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193004318 probable transmembrane helix predicted by TMHMM2.0 229193004319 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 229193004320 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 229193004321 Walker A/P-loop; other site 229193004322 ATP binding site [chemical binding]; other site 229193004323 Q-loop/lid; other site 229193004324 ABC transporter signature motif; other site 229193004325 Walker B; other site 229193004326 D-loop; other site 229193004327 H-loop/switch region; other site 229193004328 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 229193004329 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 229193004330 Walker A/P-loop; other site 229193004331 ATP binding site [chemical binding]; other site 229193004332 Q-loop/lid; other site 229193004333 ABC transporter signature motif; other site 229193004334 Walker B; other site 229193004335 D-loop; other site 229193004336 H-loop/switch region; other site 229193004337 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 229193004338 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 229193004339 probable transmembrane helix predicted by TMHMM2.0 229193004340 probable transmembrane helix predicted by TMHMM2.0 229193004341 probable transmembrane helix predicted by TMHMM2.0 229193004342 probable transmembrane helix predicted by TMHMM2.0 229193004343 probable transmembrane helix predicted by TMHMM2.0 229193004344 probable transmembrane helix predicted by TMHMM2.0 229193004345 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 229193004346 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 229193004347 probable transmembrane helix predicted by TMHMM2.0 229193004348 probable transmembrane helix predicted by TMHMM2.0 229193004349 probable transmembrane helix predicted by TMHMM2.0 229193004350 probable transmembrane helix predicted by TMHMM2.0 229193004351 probable transmembrane helix predicted by TMHMM2.0 229193004352 probable transmembrane helix predicted by TMHMM2.0 229193004353 conserved hypothetical protein; Region: TIGR02118 229193004354 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 229193004355 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193004356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193004357 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 229193004358 putative effector binding pocket; other site 229193004359 putative dimerization interface [polypeptide binding]; other site 229193004360 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 229193004361 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 229193004362 FMN binding site [chemical binding]; other site 229193004363 active site 229193004364 substrate binding site [chemical binding]; other site 229193004365 catalytic residue [active] 229193004366 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 229193004367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193004368 active site 229193004369 phosphorylation site [posttranslational modification] 229193004370 intermolecular recognition site; other site 229193004371 dimerization interface [polypeptide binding]; other site 229193004372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193004373 Walker A motif; other site 229193004374 ATP binding site [chemical binding]; other site 229193004375 Walker B motif; other site 229193004376 arginine finger; other site 229193004377 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 229193004378 ProfileScan match to entry PS50116 HTH_FIS_FAMILY, E-value 15.318 229193004379 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 229193004380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 229193004381 putative active site [active] 229193004382 heme pocket [chemical binding]; other site 229193004383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193004384 dimer interface [polypeptide binding]; other site 229193004385 phosphorylation site [posttranslational modification] 229193004386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193004387 ATP binding site [chemical binding]; other site 229193004388 Mg2+ binding site [ion binding]; other site 229193004389 G-X-G motif; other site 229193004390 probable transmembrane helix predicted by TMHMM2.0 229193004391 probable transmembrane helix predicted by TMHMM2.0 229193004392 zinc resistance protein; Provisional; Region: zraP; PRK11546 229193004393 dimer interface [polypeptide binding]; other site 229193004394 probable transmembrane helix predicted by TMHMM2.0 229193004395 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193004396 Contains Nucleoside:H+ symporter (Interpro|IPR004740, (GO:0016021)) 229193004397 xanthosine phosphorylase; Region: XAPA; TIGR01699 229193004398 EamA-like transporter family; Region: EamA; pfam00892 229193004399 probable transmembrane helix predicted by TMHMM2.0 229193004400 probable transmembrane helix predicted by TMHMM2.0 229193004401 probable transmembrane helix predicted by TMHMM2.0 229193004402 probable transmembrane helix predicted by TMHMM2.0 229193004403 probable transmembrane helix predicted by TMHMM2.0 229193004404 probable transmembrane helix predicted by TMHMM2.0 229193004405 probable transmembrane helix predicted by TMHMM2.0 229193004406 probable transmembrane helix predicted by TMHMM2.0 229193004407 probable transmembrane helix predicted by TMHMM2.0 229193004408 probable transmembrane helix predicted by TMHMM2.0 229193004409 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 229193004410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193004411 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 229193004412 putative dimerization interface [polypeptide binding]; other site 229193004413 putative substrate binding pocket [chemical binding]; other site 229193004414 choline transport protein BetT; Provisional; Region: PRK09928 229193004415 probable transmembrane helix predicted by TMHMM2.0 229193004416 probable transmembrane helix predicted by TMHMM2.0 229193004417 probable transmembrane helix predicted by TMHMM2.0 229193004418 probable transmembrane helix predicted by TMHMM2.0 229193004419 probable transmembrane helix predicted by TMHMM2.0 229193004420 probable transmembrane helix predicted by TMHMM2.0 229193004421 probable transmembrane helix predicted by TMHMM2.0 229193004422 probable transmembrane helix predicted by TMHMM2.0 229193004423 probable transmembrane helix predicted by TMHMM2.0 229193004424 probable transmembrane helix predicted by TMHMM2.0 229193004425 probable transmembrane helix predicted by TMHMM2.0 229193004426 probable transmembrane helix predicted by TMHMM2.0 229193004427 transcriptional regulator BetI; Validated; Region: PRK00767 229193004428 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 229193004429 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 229193004430 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 229193004431 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 229193004432 NAD(P) binding site [chemical binding]; other site 229193004433 catalytic residues [active] 229193004434 choline dehydrogenase; Validated; Region: PRK02106 229193004435 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 229193004436 HMMPfam match to entry PF05199 GMC_oxred_C, E-value 6.7e-99 229193004437 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193004438 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 229193004439 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 229193004440 probable transmembrane helix predicted by TMHMM2.0 229193004441 probable transmembrane helix predicted by TMHMM2.0 229193004442 probable transmembrane helix predicted by TMHMM2.0 229193004443 probable transmembrane helix predicted by TMHMM2.0 229193004444 probable transmembrane helix predicted by TMHMM2.0 229193004445 probable transmembrane helix predicted by TMHMM2.0 229193004446 probable transmembrane helix predicted by TMHMM2.0 229193004447 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 229193004448 MoaE homodimer interface [polypeptide binding]; other site 229193004449 MoaD interaction [polypeptide binding]; other site 229193004450 active site residues [active] 229193004451 BlastProDom match to entry PD004055 sp_P30749_MOAE_ECOLI, E-value 4e-38 229193004452 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 229193004453 MoaE interaction surface [polypeptide binding]; other site 229193004454 MoeB interaction surface [polypeptide binding]; other site 229193004455 thiocarboxylated glycine; other site 229193004456 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 229193004457 trimer interface [polypeptide binding]; other site 229193004458 dimer interface [polypeptide binding]; other site 229193004459 putative active site [active] 229193004460 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 229193004461 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193004462 FeS/SAM binding site; other site 229193004463 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 229193004464 HMMPfam match to entry PF04055 Radical_SAM, E-value 4.5e-36 229193004465 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 229193004466 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 229193004467 phosphate binding site [ion binding]; other site 229193004468 putative substrate binding pocket [chemical binding]; other site 229193004469 dimer interface [polypeptide binding]; other site 229193004470 Uncharacterized conserved protein [Function unknown]; Region: COG4628 229193004471 excinuclease ABC subunit B; Provisional; Region: PRK05298 229193004472 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 229193004473 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 229193004474 ATP-binding site [chemical binding]; other site 229193004475 ATP binding site [chemical binding]; other site 229193004476 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193004477 nucleotide binding region [chemical binding]; other site 229193004478 ATP-binding site [chemical binding]; other site 229193004479 Ultra-violet resistance protein B; Region: UvrB; pfam12344 229193004480 UvrB/uvrC motif; Region: UVR; pfam02151 229193004481 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 229193004482 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 229193004483 Walker A/P-loop; other site 229193004484 ATP binding site [chemical binding]; other site 229193004485 Q-loop/lid; other site 229193004486 ABC transporter signature motif; other site 229193004487 Walker B; other site 229193004488 D-loop; other site 229193004489 H-loop/switch region; other site 229193004490 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 229193004491 AAA domain; Region: AAA_26; pfam13500 229193004492 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 229193004493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193004494 S-adenosylmethionine binding site [chemical binding]; other site 229193004495 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 229193004496 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 229193004497 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193004498 catalytic residue [active] 229193004499 biotin synthase; Provisional; Region: PRK15108 229193004500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193004501 FeS/SAM binding site; other site 229193004502 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 229193004503 HMMPfam match to entry PF04055 Radical_SAM, E-value 5.2e-23 229193004504 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 229193004505 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 229193004506 inhibitor-cofactor binding pocket; inhibition site 229193004507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193004508 catalytic residue [active] 229193004509 6-phosphogluconolactonase; Provisional; Region: PRK11028 229193004510 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 229193004511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193004512 active site 229193004513 motif I; other site 229193004514 motif II; other site 229193004515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193004516 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 229193004517 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193004518 Walker A/P-loop; other site 229193004519 ATP binding site [chemical binding]; other site 229193004520 Q-loop/lid; other site 229193004521 ABC transporter signature motif; other site 229193004522 Walker B; other site 229193004523 D-loop; other site 229193004524 H-loop/switch region; other site 229193004525 molybdenum-pterin binding domain; Region: Mop; TIGR00638 229193004526 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 229193004527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193004528 dimer interface [polypeptide binding]; other site 229193004529 conserved gate region; other site 229193004530 putative PBP binding loops; other site 229193004531 ABC-ATPase subunit interface; other site 229193004532 probable transmembrane helix predicted by TMHMM2.0 229193004533 probable transmembrane helix predicted by TMHMM2.0 229193004534 probable transmembrane helix predicted by TMHMM2.0 229193004535 probable transmembrane helix predicted by TMHMM2.0 229193004536 probable transmembrane helix predicted by TMHMM2.0 229193004537 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 229193004538 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 229193004539 probable transmembrane helix predicted by TMHMM2.0 229193004540 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 229193004541 probable transmembrane helix predicted by TMHMM2.0 229193004542 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 229193004543 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 229193004544 molybdenum-pterin binding domain; Region: Mop; TIGR00638 229193004545 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 229193004546 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 229193004547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193004548 Walker A/P-loop; other site 229193004549 ATP binding site [chemical binding]; other site 229193004550 ABC transporter signature motif; other site 229193004551 Walker B; other site 229193004552 D-loop; other site 229193004553 H-loop/switch region; other site 229193004554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193004555 Walker A/P-loop; other site 229193004556 ATP binding site [chemical binding]; other site 229193004557 Q-loop/lid; other site 229193004558 ABC transporter signature motif; other site 229193004559 Walker B; other site 229193004560 D-loop; other site 229193004561 H-loop/switch region; other site 229193004562 CAAX protease self-immunity; Region: Abi; pfam02517 229193004563 ProfileScan match to entry PS50319 LEU_RICH, E-value 9.484 229193004564 probable transmembrane helix predicted by TMHMM2.0 229193004565 probable transmembrane helix predicted by TMHMM2.0 229193004566 probable transmembrane helix predicted by TMHMM2.0 229193004567 probable transmembrane helix predicted by TMHMM2.0 229193004568 probable transmembrane helix predicted by TMHMM2.0 229193004569 probable transmembrane helix predicted by TMHMM2.0 229193004570 probable transmembrane helix predicted by TMHMM2.0 229193004571 probable transmembrane helix predicted by TMHMM2.0 229193004572 probable transmembrane helix predicted by TMHMM2.0 229193004573 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 229193004574 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 229193004575 NAD binding site [chemical binding]; other site 229193004576 homodimer interface [polypeptide binding]; other site 229193004577 active site 229193004578 substrate binding site [chemical binding]; other site 229193004579 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 229193004580 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 229193004581 dimer interface [polypeptide binding]; other site 229193004582 active site 229193004583 galactokinase; Provisional; Region: PRK05101 229193004584 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 229193004585 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 229193004586 Contains Aldose 1-epimerase (Interpro|IPR001823, (GO:0006012)) . Contains Aldose 1-epimerase (Interpro|IPR001823, (GO:0006012)) 229193004587 psiF repeat; Region: PsiF_repeat; pfam07769 229193004588 psiF repeat; Region: PsiF_repeat; pfam07769 229193004589 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 229193004590 catalytic core [active] 229193004591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 229193004592 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 229193004593 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 229193004594 zinc transporter ZitB; Provisional; Region: PRK03557 229193004595 probable transmembrane helix predicted by TMHMM2.0 229193004596 probable transmembrane helix predicted by TMHMM2.0 229193004597 probable transmembrane helix predicted by TMHMM2.0 229193004598 probable transmembrane helix predicted by TMHMM2.0 229193004599 probable transmembrane helix predicted by TMHMM2.0 229193004600 ProfileScan match to entry PS50316 HIS_RICH, E-value 8.537 229193004601 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 229193004602 probable transmembrane helix predicted by TMHMM2.0 229193004603 probable transmembrane helix predicted by TMHMM2.0 229193004604 probable transmembrane helix predicted by TMHMM2.0 229193004605 probable transmembrane helix predicted by TMHMM2.0 229193004606 probable transmembrane helix predicted by TMHMM2.0 229193004607 probable transmembrane helix predicted by TMHMM2.0 229193004608 probable transmembrane helix predicted by TMHMM2.0 229193004609 quinolinate synthetase; Provisional; Region: PRK09375 229193004610 tol-pal system protein YbgF; Provisional; Region: PRK10803 229193004611 Tetratricopeptide repeat; Region: TPR_6; pfam13174 229193004612 ProfileScan match to entry PS50310 ALA_RICH, E-value 9.353 229193004613 ProfileScan match to entry PS50322 GLN_RICH, E-value 9.781 229193004614 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 229193004615 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 229193004616 ligand binding site [chemical binding]; other site 229193004617 translocation protein TolB; Provisional; Region: tolB; PRK03629 229193004618 TolB amino-terminal domain; Region: TolB_N; pfam04052 229193004619 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 229193004620 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 229193004621 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 229193004622 HMMPfam match to entry PF04052 TolB_N, E-value 1.1e-77 229193004623 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 229193004624 TolA C-terminal; Region: TolA; pfam06519 229193004625 ProfileScan match to entry PS50310 ALA_RICH, E-value 32.507 229193004626 ProfileScan match to entry PS50322 GLN_RICH, E-value 15.944 229193004627 probable transmembrane helix predicted by TMHMM2.0 229193004628 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 229193004629 colicin uptake protein TolR; Provisional; Region: PRK11024 229193004630 probable transmembrane helix predicted by TMHMM2.0 229193004631 colicin uptake protein TolQ; Provisional; Region: PRK10801 229193004632 BlastProDom match to entry PD003317 sp_Q9KR08_Q9KR08_VIBCH, E-value 1e-34 229193004633 probable transmembrane helix predicted by TMHMM2.0 229193004634 probable transmembrane helix predicted by TMHMM2.0 229193004635 probable transmembrane helix predicted by TMHMM2.0 229193004636 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 229193004637 active site 229193004638 hypothetical protein; Provisional; Region: PRK10588 229193004639 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 229193004640 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 229193004641 probable transmembrane helix predicted by TMHMM2.0 229193004642 probable transmembrane helix predicted by TMHMM2.0 229193004643 probable transmembrane helix predicted by TMHMM2.0 229193004644 probable transmembrane helix predicted by TMHMM2.0 229193004645 probable transmembrane helix predicted by TMHMM2.0 229193004646 probable transmembrane helix predicted by TMHMM2.0 229193004647 probable transmembrane helix predicted by TMHMM2.0 229193004648 probable transmembrane helix predicted by TMHMM2.0 229193004649 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 229193004650 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 229193004651 probable transmembrane helix predicted by TMHMM2.0 229193004652 probable transmembrane helix predicted by TMHMM2.0 229193004653 probable transmembrane helix predicted by TMHMM2.0 229193004654 probable transmembrane helix predicted by TMHMM2.0 229193004655 probable transmembrane helix predicted by TMHMM2.0 229193004656 probable transmembrane helix predicted by TMHMM2.0 229193004657 probable transmembrane helix predicted by TMHMM2.0 229193004658 probable transmembrane helix predicted by TMHMM2.0 229193004659 probable transmembrane helix predicted by TMHMM2.0 229193004660 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 229193004661 CoA binding domain; Region: CoA_binding; smart00881 229193004662 CoA-ligase; Region: Ligase_CoA; pfam00549 229193004663 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 229193004664 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 229193004665 CoA-ligase; Region: Ligase_CoA; pfam00549 229193004666 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 229193004667 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 229193004668 E3 interaction surface; other site 229193004669 lipoyl attachment site [posttranslational modification]; other site 229193004670 e3 binding domain; Region: E3_binding; pfam02817 229193004671 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 229193004672 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 229193004673 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 229193004674 TPP-binding site [chemical binding]; other site 229193004675 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 229193004676 dimer interface [polypeptide binding]; other site 229193004677 PYR/PP interface [polypeptide binding]; other site 229193004678 TPP binding site [chemical binding]; other site 229193004679 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 229193004680 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 229193004681 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 229193004682 L-aspartate oxidase; Provisional; Region: PRK06175 229193004683 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 229193004684 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 229193004685 SdhC subunit interface [polypeptide binding]; other site 229193004686 proximal heme binding site [chemical binding]; other site 229193004687 cardiolipin binding site; other site 229193004688 Iron-sulfur protein interface; other site 229193004689 proximal quinone binding site [chemical binding]; other site 229193004690 probable transmembrane helix predicted by TMHMM2.0 229193004691 BlastProDom match to entry PD012698 sp_P10445_DHSD_ECOLI, E-value 6e-29 229193004692 probable transmembrane helix predicted by TMHMM2.0 229193004693 probable transmembrane helix predicted by TMHMM2.0 229193004694 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 229193004695 Iron-sulfur protein interface; other site 229193004696 proximal quinone binding site [chemical binding]; other site 229193004697 SdhD (CybS) interface [polypeptide binding]; other site 229193004698 proximal heme binding site [chemical binding]; other site 229193004699 BlastProDom match to entry PD003634 sp_P10446_DHSC_ECOLI, E-value 1e-51 229193004700 probable transmembrane helix predicted by TMHMM2.0 229193004701 probable transmembrane helix predicted by TMHMM2.0 229193004702 probable transmembrane helix predicted by TMHMM2.0 229193004703 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 229193004704 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 229193004705 dimer interface [polypeptide binding]; other site 229193004706 active site 229193004707 citrylCoA binding site [chemical binding]; other site 229193004708 NADH binding [chemical binding]; other site 229193004709 cationic pore residues; other site 229193004710 oxalacetate/citrate binding site [chemical binding]; other site 229193004711 coenzyme A binding site [chemical binding]; other site 229193004712 catalytic triad [active] 229193004713 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 229193004714 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 229193004715 dimer interface [polypeptide binding]; other site 229193004716 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 229193004717 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 229193004718 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 229193004719 recombination and repair protein; Provisional; Region: PRK10869 229193004720 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 229193004721 Walker A/P-loop; other site 229193004722 ATP binding site [chemical binding]; other site 229193004723 Q-loop/lid; other site 229193004724 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 229193004725 Q-loop/lid; other site 229193004726 ABC transporter signature motif; other site 229193004727 Walker B; other site 229193004728 D-loop; other site 229193004729 H-loop/switch region; other site 229193004730 probable transmembrane helix predicted by TMHMM2.0 229193004731 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 229193004732 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 229193004733 HMMPfam match to entry PF04355 SmpA_OmlA, E-value 1.3e-33 229193004734 hypothetical protein; Validated; Region: PRK01777 229193004735 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 229193004736 putative coenzyme Q binding site [chemical binding]; other site 229193004737 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 229193004738 SmpB-tmRNA interface; other site 229193004739 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193004740 integrase; Provisional; Region: PRK09692 229193004741 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 229193004742 active site 229193004743 Int/Topo IB signature motif; other site 229193004744 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 229193004745 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 229193004746 Integrase; Region: Integrase_1; pfam12835 229193004747 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 229193004748 Ash protein family; Region: Phage_ASH; pfam10554 229193004749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 229193004750 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 229193004751 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 229193004752 active site 229193004753 metal binding site [ion binding]; metal-binding site 229193004754 interdomain interaction site; other site 229193004755 AAA domain; Region: AAA_25; pfam13481 229193004756 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 229193004757 Walker A motif; other site 229193004758 ATP binding site [chemical binding]; other site 229193004759 Walker B motif; other site 229193004760 Predicted transcriptional regulator [Transcription]; Region: COG3636 229193004761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3657 229193004762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193004763 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193004764 DNA-binding interface [nucleotide binding]; DNA binding site 229193004765 Integrase core domain; Region: rve; pfam00665 229193004766 transposase/IS protein; Provisional; Region: PRK09183 229193004767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193004768 Walker A motif; other site 229193004769 ATP binding site [chemical binding]; other site 229193004770 Walker B motif; other site 229193004771 Contains Phage integrase (Interpro|IPR002104, (GO:0015074)) 229193004772 Transposase; Region: HTH_Tnp_1; pfam01527 229193004773 BlastProDom match to entry PD002176 sp_Q9X9H8_Q9X9H8_YEREN, E-value 5e-20 229193004774 acyl-CoA esterase; Provisional; Region: PRK10673 229193004775 PGAP1-like protein; Region: PGAP1; pfam07819 229193004776 LexA regulated protein; Provisional; Region: PRK11675 229193004777 flavodoxin FldA; Validated; Region: PRK09267 229193004778 ferric uptake regulator; Provisional; Region: fur; PRK09462 229193004779 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 229193004780 metal binding site 2 [ion binding]; metal-binding site 229193004781 putative DNA binding helix; other site 229193004782 metal binding site 1 [ion binding]; metal-binding site 229193004783 dimer interface [polypeptide binding]; other site 229193004784 structural Zn2+ binding site [ion binding]; other site 229193004785 Contains Glycoside hydrolase, family 20 (Interpro|IPR001540, (GO:0005975)) . Contains Glycoside hydrolase, family 20 (Interpro|IPR001540, (GO:0005975)). Contains Glycoside hydrolase, family 20, C-terminal (Interpro|IPR004867, (GO:0005975)). Contains carbohydrate binding domain (Interpro|IPR004866, (GO:0030246)) 229193004786 outer membrane porin, OprD family; Region: OprD; pfam03573 229193004787 probable transmembrane helix predicted by TMHMM2.0 229193004788 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 229193004789 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 229193004790 active site 229193004791 HIGH motif; other site 229193004792 nucleotide binding site [chemical binding]; other site 229193004793 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 229193004794 KMSKS motif; other site 229193004795 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 229193004796 probable transmembrane helix predicted by TMHMM2.0 229193004797 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 229193004798 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 229193004799 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 229193004800 active site turn [active] 229193004801 phosphorylation site [posttranslational modification] 229193004802 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 229193004803 HPr interaction site; other site 229193004804 glycerol kinase (GK) interaction site [polypeptide binding]; other site 229193004805 active site 229193004806 phosphorylation site [posttranslational modification] 229193004807 probable transmembrane helix predicted by TMHMM2.0 229193004808 probable transmembrane helix predicted by TMHMM2.0 229193004809 probable transmembrane helix predicted by TMHMM2.0 229193004810 probable transmembrane helix predicted by TMHMM2.0 229193004811 probable transmembrane helix predicted by TMHMM2.0 229193004812 probable transmembrane helix predicted by TMHMM2.0 229193004813 probable transmembrane helix predicted by TMHMM2.0 229193004814 probable transmembrane helix predicted by TMHMM2.0 229193004815 probable transmembrane helix predicted by TMHMM2.0 229193004816 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 229193004817 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 229193004818 active site 229193004819 trimer interface [polypeptide binding]; other site 229193004820 allosteric site; other site 229193004821 active site lid [active] 229193004822 hexamer (dimer of trimers) interface [polypeptide binding]; other site 229193004823 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 229193004824 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 229193004825 active site 229193004826 dimer interface [polypeptide binding]; other site 229193004827 MarR family; Region: MarR; pfam01047 229193004828 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 229193004829 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 229193004830 nucleotide binding site [chemical binding]; other site 229193004831 asparagine synthetase B; Provisional; Region: asnB; PRK09431 229193004832 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 229193004833 active site 229193004834 dimer interface [polypeptide binding]; other site 229193004835 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 229193004836 Ligand Binding Site [chemical binding]; other site 229193004837 Molecular Tunnel; other site 229193004838 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 229193004839 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 229193004840 probable transmembrane helix predicted by TMHMM2.0 229193004841 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 229193004842 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 229193004843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193004844 FeS/SAM binding site; other site 229193004845 TRAM domain; Region: TRAM; pfam01938 229193004846 HMMPfam match to entry PF04055 Radical_SAM, E-value 1.1e-31 229193004847 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 229193004848 PhoH-like protein; Region: PhoH; pfam02562 229193004849 metal-binding heat shock protein; Provisional; Region: PRK00016 229193004850 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 229193004851 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 229193004852 Transporter associated domain; Region: CorC_HlyC; smart01091 229193004853 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 229193004854 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 229193004855 putative active site [active] 229193004856 catalytic triad [active] 229193004857 putative dimer interface [polypeptide binding]; other site 229193004858 probable transmembrane helix predicted by TMHMM2.0 229193004859 probable transmembrane helix predicted by TMHMM2.0 229193004860 probable transmembrane helix predicted by TMHMM2.0 229193004861 probable transmembrane helix predicted by TMHMM2.0 229193004862 probable transmembrane helix predicted by TMHMM2.0 229193004863 probable transmembrane helix predicted by TMHMM2.0 229193004864 probable transmembrane helix predicted by TMHMM2.0 229193004865 probable transmembrane helix predicted by TMHMM2.0 229193004866 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 229193004867 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193004868 substrate binding pocket [chemical binding]; other site 229193004869 membrane-bound complex binding site; other site 229193004870 hinge residues; other site 229193004871 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 229193004872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193004873 dimer interface [polypeptide binding]; other site 229193004874 conserved gate region; other site 229193004875 putative PBP binding loops; other site 229193004876 ABC-ATPase subunit interface; other site 229193004877 probable transmembrane helix predicted by TMHMM2.0 229193004878 probable transmembrane helix predicted by TMHMM2.0 229193004879 probable transmembrane helix predicted by TMHMM2.0 229193004880 probable transmembrane helix predicted by TMHMM2.0 229193004881 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 229193004882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193004883 dimer interface [polypeptide binding]; other site 229193004884 conserved gate region; other site 229193004885 putative PBP binding loops; other site 229193004886 ABC-ATPase subunit interface; other site 229193004887 probable transmembrane helix predicted by TMHMM2.0 229193004888 probable transmembrane helix predicted by TMHMM2.0 229193004889 probable transmembrane helix predicted by TMHMM2.0 229193004890 probable transmembrane helix predicted by TMHMM2.0 229193004891 probable transmembrane helix predicted by TMHMM2.0 229193004892 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 229193004893 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 229193004894 Walker A/P-loop; other site 229193004895 ATP binding site [chemical binding]; other site 229193004896 Q-loop/lid; other site 229193004897 ABC transporter signature motif; other site 229193004898 Walker B; other site 229193004899 D-loop; other site 229193004900 H-loop/switch region; other site 229193004901 hypothetical protein; Provisional; Region: PRK11032 229193004902 Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488 229193004903 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 229193004904 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 229193004905 HIGH motif; other site 229193004906 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 229193004907 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 229193004908 active site 229193004909 KMSKS motif; other site 229193004910 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 229193004911 tRNA binding surface [nucleotide binding]; other site 229193004912 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 229193004913 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 229193004914 probable transmembrane helix predicted by TMHMM2.0 229193004915 HMMPfam match to entry PF04390 RplB, E-value 7.5e-63 229193004916 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 229193004917 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 229193004918 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 229193004919 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 229193004920 active site 229193004921 (T/H)XGH motif; other site 229193004922 ribosome-associated protein; Provisional; Region: PRK11538 229193004923 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 229193004924 penicillin-binding protein 2; Provisional; Region: PRK10795 229193004925 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 229193004926 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 229193004927 probable transmembrane helix predicted by TMHMM2.0 229193004928 cell wall shape-determining protein; Provisional; Region: PRK10794 229193004929 probable transmembrane helix predicted by TMHMM2.0 229193004930 probable transmembrane helix predicted by TMHMM2.0 229193004931 probable transmembrane helix predicted by TMHMM2.0 229193004932 probable transmembrane helix predicted by TMHMM2.0 229193004933 probable transmembrane helix predicted by TMHMM2.0 229193004934 probable transmembrane helix predicted by TMHMM2.0 229193004935 probable transmembrane helix predicted by TMHMM2.0 229193004936 probable transmembrane helix predicted by TMHMM2.0 229193004937 probable transmembrane helix predicted by TMHMM2.0 229193004938 rare lipoprotein A; Provisional; Region: PRK10672 229193004939 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 229193004940 Sporulation related domain; Region: SPOR; pfam05036 229193004941 HMMPfam match to entry PF05036 SPOR, E-value 0.022 229193004942 HMMPfam match to entry PF05036 SPOR, E-value 1.6e-06 229193004943 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 229193004944 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 229193004945 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 229193004946 hypothetical protein; Provisional; Region: PRK04998 229193004947 HMMPfam match to entry PF04359 DUF493, E-value 6.3e-52 229193004948 lipoate-protein ligase B; Provisional; Region: PRK14342 229193004949 lipoyl synthase; Provisional; Region: PRK05481 229193004950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193004951 FeS/SAM binding site; other site 229193004952 HMMPfam match to entry PF04055 Radical_SAM, E-value 1.1e-24 229193004953 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 229193004954 probable transmembrane helix predicted by TMHMM2.0 229193004955 chromosome condensation membrane protein; Provisional; Region: PRK14196 229193004956 probable transmembrane helix predicted by TMHMM2.0 229193004957 probable transmembrane helix predicted by TMHMM2.0 229193004958 probable transmembrane helix predicted by TMHMM2.0 229193004959 probable transmembrane helix predicted by TMHMM2.0 229193004960 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 229193004961 DNA-binding site [nucleotide binding]; DNA binding site 229193004962 RNA-binding motif; other site 229193004963 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 229193004964 DNA-binding site [nucleotide binding]; DNA binding site 229193004965 RNA-binding motif; other site 229193004966 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 229193004967 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193004968 DNA binding residues [nucleotide binding] 229193004969 dimerization interface [polypeptide binding]; other site 229193004970 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 229193004971 probable transmembrane helix predicted by TMHMM2.0 229193004972 probable transmembrane helix predicted by TMHMM2.0 229193004973 probable transmembrane helix predicted by TMHMM2.0 229193004974 probable transmembrane helix predicted by TMHMM2.0 229193004975 probable transmembrane helix predicted by TMHMM2.0 229193004976 probable transmembrane helix predicted by TMHMM2.0 229193004977 probable transmembrane helix predicted by TMHMM2.0 229193004978 probable transmembrane helix predicted by TMHMM2.0 229193004979 probable transmembrane helix predicted by TMHMM2.0 229193004980 Glycogen synthesis protein; Region: GlgS; cl11663 229193004981 Uncharacterized conserved protein [Function unknown]; Region: COG1359 229193004982 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 229193004983 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 229193004984 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 229193004985 Walker A/P-loop; other site 229193004986 ATP binding site [chemical binding]; other site 229193004987 Q-loop/lid; other site 229193004988 ABC transporter signature motif; other site 229193004989 Walker B; other site 229193004990 D-loop; other site 229193004991 H-loop/switch region; other site 229193004992 probable transmembrane helix predicted by TMHMM2.0 229193004993 probable transmembrane helix predicted by TMHMM2.0 229193004994 probable transmembrane helix predicted by TMHMM2.0 229193004995 probable transmembrane helix predicted by TMHMM2.0 229193004996 probable transmembrane helix predicted by TMHMM2.0 229193004997 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 229193004998 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 229193004999 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 229193005000 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 229193005001 substrate binding site [chemical binding]; other site 229193005002 ATP binding site [chemical binding]; other site 229193005003 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 229193005004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 229193005005 BlastProDom match to entry PD023180 sp_Q9A8Q5_Q9A8Q5_CAUCR, E-value 5e-26 229193005006 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 229193005007 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 229193005008 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193005009 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193005010 TM-ABC transporter signature motif; other site 229193005011 probable transmembrane helix predicted by TMHMM2.0 229193005012 probable transmembrane helix predicted by TMHMM2.0 229193005013 probable transmembrane helix predicted by TMHMM2.0 229193005014 probable transmembrane helix predicted by TMHMM2.0 229193005015 probable transmembrane helix predicted by TMHMM2.0 229193005016 probable transmembrane helix predicted by TMHMM2.0 229193005017 probable transmembrane helix predicted by TMHMM2.0 229193005018 probable transmembrane helix predicted by TMHMM2.0 229193005019 probable transmembrane helix predicted by TMHMM2.0 229193005020 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 229193005021 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193005022 Walker A/P-loop; other site 229193005023 ATP binding site [chemical binding]; other site 229193005024 Q-loop/lid; other site 229193005025 ABC transporter signature motif; other site 229193005026 Walker B; other site 229193005027 D-loop; other site 229193005028 H-loop/switch region; other site 229193005029 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193005030 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 229193005031 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 229193005032 ligand binding site [chemical binding]; other site 229193005033 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 229193005034 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 229193005035 PYR/PP interface [polypeptide binding]; other site 229193005036 dimer interface [polypeptide binding]; other site 229193005037 TPP binding site [chemical binding]; other site 229193005038 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 229193005039 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 229193005040 TPP-binding site; other site 229193005041 probable transmembrane helix predicted by TMHMM2.0 229193005042 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 229193005043 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 229193005044 tetrameric interface [polypeptide binding]; other site 229193005045 NAD binding site [chemical binding]; other site 229193005046 catalytic residues [active] 229193005047 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 229193005048 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 229193005049 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 229193005050 putative active site [active] 229193005051 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 229193005052 probable transmembrane helix predicted by TMHMM2.0 229193005053 probable transmembrane helix predicted by TMHMM2.0 229193005054 probable transmembrane helix predicted by TMHMM2.0 229193005055 probable transmembrane helix predicted by TMHMM2.0 229193005056 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 229193005057 MG2 domain; Region: A2M_N; pfam01835 229193005058 Alpha-2-macroglobulin family; Region: A2M; pfam00207 229193005059 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 229193005060 surface patch; other site 229193005061 thioester region; other site 229193005062 specificity defining residues; other site 229193005063 probable transmembrane helix predicted by TMHMM2.0 229193005064 probable transmembrane helix predicted by TMHMM2.0 229193005065 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 229193005066 Transglycosylase; Region: Transgly; pfam00912 229193005067 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 229193005068 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 229193005069 probable transmembrane helix predicted by TMHMM2.0 229193005070 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 229193005071 probable transmembrane helix predicted by TMHMM2.0 229193005072 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 229193005073 probable transmembrane helix predicted by TMHMM2.0 229193005074 probable transmembrane helix predicted by TMHMM2.0 229193005075 probable transmembrane helix predicted by TMHMM2.0 229193005076 probable transmembrane helix predicted by TMHMM2.0 229193005077 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 229193005078 probable transmembrane helix predicted by TMHMM2.0 229193005079 probable transmembrane helix predicted by TMHMM2.0 229193005080 probable transmembrane helix predicted by TMHMM2.0 229193005081 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 229193005082 probable transmembrane helix predicted by TMHMM2.0 229193005083 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 229193005084 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 229193005085 Autotransporter beta-domain; Region: Autotransporter; pfam03797 229193005086 probable transmembrane helix predicted by TMHMM2.0 229193005087 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 229193005088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193005089 MULE transposase domain; Region: MULE; pfam10551 229193005090 probable transmembrane helix predicted by TMHMM2.0 229193005091 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 229193005092 Predicted membrane protein [Function unknown]; Region: COG4984 229193005093 probable transmembrane helix predicted by TMHMM2.0 229193005094 probable transmembrane helix predicted by TMHMM2.0 229193005095 probable transmembrane helix predicted by TMHMM2.0 229193005096 probable transmembrane helix predicted by TMHMM2.0 229193005097 probable transmembrane helix predicted by TMHMM2.0 229193005098 probable transmembrane helix predicted by TMHMM2.0 229193005099 probable transmembrane helix predicted by TMHMM2.0 229193005100 probable transmembrane helix predicted by TMHMM2.0 229193005101 probable transmembrane helix predicted by TMHMM2.0 229193005102 probable transmembrane helix predicted by TMHMM2.0 229193005103 probable transmembrane helix predicted by TMHMM2.0 229193005104 probable transmembrane helix predicted by TMHMM2.0 229193005105 probable transmembrane helix predicted by TMHMM2.0 229193005106 probable transmembrane helix predicted by TMHMM2.0 229193005107 probable transmembrane helix predicted by TMHMM2.0 229193005108 probable transmembrane helix predicted by TMHMM2.0 229193005109 probable transmembrane helix predicted by TMHMM2.0 229193005110 probable transmembrane helix predicted by TMHMM2.0 229193005111 probable transmembrane helix predicted by TMHMM2.0 229193005112 probable transmembrane helix predicted by TMHMM2.0 229193005113 probable transmembrane helix predicted by TMHMM2.0 229193005114 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 229193005115 probable transmembrane helix predicted by TMHMM2.0 229193005116 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 229193005117 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 229193005118 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 229193005119 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 229193005120 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 229193005121 active site 229193005122 catalytic tetrad [active] 229193005123 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 229193005124 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 229193005125 active site 229193005126 catalytic tetrad [active] 229193005127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193005128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193005129 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 229193005130 putative effector binding pocket; other site 229193005131 putative dimerization interface [polypeptide binding]; other site 229193005132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193005133 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193005134 DNA-binding interface [nucleotide binding]; DNA binding site 229193005135 Integrase core domain; Region: rve; pfam00665 229193005136 transposase/IS protein; Provisional; Region: PRK09183 229193005137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193005138 Walker A motif; other site 229193005139 ATP binding site [chemical binding]; other site 229193005140 Walker B motif; other site 229193005141 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193005142 Ribosome modulation factor; Region: RMF; pfam04957 229193005143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 229193005144 Protein of unknown function (DUF330); Region: DUF330; pfam03886 229193005145 paraquat-inducible protein B; Provisional; Region: PRK10807 229193005146 mce related protein; Region: MCE; pfam02470 229193005147 mce related protein; Region: MCE; pfam02470 229193005148 mce related protein; Region: MCE; pfam02470 229193005149 probable transmembrane helix predicted by TMHMM2.0 229193005150 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 229193005151 Paraquat-inducible protein A; Region: PqiA; pfam04403 229193005152 Paraquat-inducible protein A; Region: PqiA; pfam04403 229193005153 HMMPfam match to entry PF04403 PqiA, E-value 1.7e-92 229193005154 probable transmembrane helix predicted by TMHMM2.0 229193005155 probable transmembrane helix predicted by TMHMM2.0 229193005156 probable transmembrane helix predicted by TMHMM2.0 229193005157 probable transmembrane helix predicted by TMHMM2.0 229193005158 HMMPfam match to entry PF04403 PqiA, E-value 1e-63 229193005159 probable transmembrane helix predicted by TMHMM2.0 229193005160 probable transmembrane helix predicted by TMHMM2.0 229193005161 probable transmembrane helix predicted by TMHMM2.0 229193005162 probable transmembrane helix predicted by TMHMM2.0 229193005163 ABC transporter ATPase component; Reviewed; Region: PRK11147 229193005164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193005165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193005166 Walker A/P-loop; other site 229193005167 Walker A/P-loop; other site 229193005168 ATP binding site [chemical binding]; other site 229193005169 ATP binding site [chemical binding]; other site 229193005170 Q-loop/lid; other site 229193005171 Q-loop/lid; other site 229193005172 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 229193005173 ABC transporter signature motif; other site 229193005174 Walker B; other site 229193005175 D-loop; other site 229193005176 ABC transporter; Region: ABC_tran_2; pfam12848 229193005177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 229193005178 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 229193005179 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 229193005180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193005181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193005182 S-adenosylmethionine binding site [chemical binding]; other site 229193005183 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 229193005184 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 229193005185 MOSC domain; Region: MOSC; pfam03473 229193005186 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 229193005187 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 229193005188 catalytic loop [active] 229193005189 iron binding site [ion binding]; other site 229193005190 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 229193005191 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 229193005192 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 229193005193 active site 229193005194 catalytic residues [active] 229193005195 FMN binding site [chemical binding]; other site 229193005196 quinone interaction residues [chemical binding]; other site 229193005197 substrate binding site [chemical binding]; other site 229193005198 aminopeptidase N; Provisional; Region: pepN; PRK14015 229193005199 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 229193005200 active site 229193005201 Zn binding site [ion binding]; other site 229193005202 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 229193005203 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 229193005204 active site 229193005205 HMMPfam match to entry PF04095 NAPRTase, E-value 6.5e-174 229193005206 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 229193005207 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 229193005208 putative dimer interface [polypeptide binding]; other site 229193005209 putative anticodon binding site; other site 229193005210 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 229193005211 homodimer interface [polypeptide binding]; other site 229193005212 motif 1; other site 229193005213 motif 2; other site 229193005214 active site 229193005215 motif 3; other site 229193005216 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 229193005217 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 229193005218 trimer interface [polypeptide binding]; other site 229193005219 eyelet of channel; other site 229193005220 probable transmembrane helix predicted by TMHMM2.0 229193005221 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 229193005222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 229193005223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193005224 homodimer interface [polypeptide binding]; other site 229193005225 catalytic residue [active] 229193005226 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 229193005227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 229193005228 Peptidase M15; Region: Peptidase_M15_3; cl01194 229193005229 probable transmembrane helix predicted by TMHMM2.0 229193005230 murein L,D-transpeptidase; Provisional; Region: PRK10594 229193005231 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 229193005232 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 229193005233 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 229193005234 probable transmembrane helix predicted by TMHMM2.0 229193005235 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193005236 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 229193005237 P-loop containing region of AAA domain; Region: AAA_29; cl17516 229193005238 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 229193005239 HMMPfam match to entry PF04310 MukB, E-value 1.8e-177 229193005240 condesin subunit E; Provisional; Region: PRK05256 229193005241 HMMPfam match to entry PF04288 MukE, E-value 2.1e-148 229193005242 condesin subunit F; Provisional; Region: PRK05260 229193005243 Methyltransferase domain; Region: Methyltransf_31; pfam13847 229193005244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193005245 S-adenosylmethionine binding site [chemical binding]; other site 229193005246 hypothetical protein; Provisional; Region: PRK10593 229193005247 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 229193005248 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 229193005249 Ligand binding site; other site 229193005250 oligomer interface; other site 229193005251 Trm112p-like protein; Region: Trm112p; cl01066 229193005252 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 229193005253 DNA-binding site [nucleotide binding]; DNA binding site 229193005254 RNA-binding motif; other site 229193005255 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 229193005256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 229193005257 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 229193005258 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 229193005259 BlastProDom match to entry PD014061 sp_P27300_LPXK_ECOLI, E-value 2e-35 229193005260 probable transmembrane helix predicted by TMHMM2.0 229193005261 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 229193005262 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 229193005263 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 229193005264 Walker A/P-loop; other site 229193005265 ATP binding site [chemical binding]; other site 229193005266 Q-loop/lid; other site 229193005267 ABC transporter signature motif; other site 229193005268 Walker B; other site 229193005269 D-loop; other site 229193005270 H-loop/switch region; other site 229193005271 probable transmembrane helix predicted by TMHMM2.0 229193005272 probable transmembrane helix predicted by TMHMM2.0 229193005273 probable transmembrane helix predicted by TMHMM2.0 229193005274 probable transmembrane helix predicted by TMHMM2.0 229193005275 probable transmembrane helix predicted by TMHMM2.0 229193005276 probable transmembrane helix predicted by TMHMM2.0 229193005277 ComEC family competence protein; Provisional; Region: PRK11539 229193005278 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 229193005279 Competence protein; Region: Competence; pfam03772 229193005280 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 229193005281 probable transmembrane helix predicted by TMHMM2.0 229193005282 probable transmembrane helix predicted by TMHMM2.0 229193005283 probable transmembrane helix predicted by TMHMM2.0 229193005284 probable transmembrane helix predicted by TMHMM2.0 229193005285 probable transmembrane helix predicted by TMHMM2.0 229193005286 probable transmembrane helix predicted by TMHMM2.0 229193005287 probable transmembrane helix predicted by TMHMM2.0 229193005288 probable transmembrane helix predicted by TMHMM2.0 229193005289 probable transmembrane helix predicted by TMHMM2.0 229193005290 probable transmembrane helix predicted by TMHMM2.0 229193005291 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 229193005292 IHF dimer interface [polypeptide binding]; other site 229193005293 IHF - DNA interface [nucleotide binding]; other site 229193005294 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 229193005295 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 229193005296 RNA binding site [nucleotide binding]; other site 229193005297 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 229193005298 RNA binding site [nucleotide binding]; other site 229193005299 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 229193005300 RNA binding site [nucleotide binding]; other site 229193005301 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 229193005302 RNA binding site [nucleotide binding]; other site 229193005303 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 229193005304 RNA binding site [nucleotide binding]; other site 229193005305 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 229193005306 RNA binding site [nucleotide binding]; other site 229193005307 cytidylate kinase; Provisional; Region: cmk; PRK00023 229193005308 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 229193005309 CMP-binding site; other site 229193005310 The sites determining sugar specificity; other site 229193005311 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 229193005312 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 229193005313 hinge; other site 229193005314 active site 229193005315 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 229193005316 homodimer interface [polypeptide binding]; other site 229193005317 substrate-cofactor binding pocket; other site 229193005318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193005319 catalytic residue [active] 229193005320 YadA-like C-terminal region; Region: YadA; pfam03895 229193005321 ProfileScan match to entry PS50321 ASN_RICH, E-value 17.147 229193005322 probable transmembrane helix predicted by TMHMM2.0 229193005323 Haemagglutinin; Region: HIM; pfam05662 229193005324 YadA-like C-terminal region; Region: YadA; pfam03895 229193005325 ProfileScan match to entry PS50315 GLY_RICH, E-value 10.004 229193005326 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 229193005327 active site 229193005328 homodimer interface [polypeptide binding]; other site 229193005329 homotetramer interface [polypeptide binding]; other site 229193005330 probable transmembrane helix predicted by TMHMM2.0 229193005331 uncharacterized domain; Region: TIGR00702 229193005332 YcaO-like family; Region: YcaO; pfam02624 229193005333 formate transporter; Provisional; Region: PRK10805 229193005334 probable transmembrane helix predicted by TMHMM2.0 229193005335 BlastProDom match to entry PD006963 sp_P21501_FOCA_ECOLI, E-value e-106 229193005336 probable transmembrane helix predicted by TMHMM2.0 229193005337 probable transmembrane helix predicted by TMHMM2.0 229193005338 probable transmembrane helix predicted by TMHMM2.0 229193005339 probable transmembrane helix predicted by TMHMM2.0 229193005340 probable transmembrane helix predicted by TMHMM2.0 229193005341 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 229193005342 Pyruvate formate lyase 1; Region: PFL1; cd01678 229193005343 coenzyme A binding site [chemical binding]; other site 229193005344 active site 229193005345 catalytic residues [active] 229193005346 glycine loop; other site 229193005347 BlastProDom match to entry PD004056 sp_P09373_PFLB_ECOLI, E-value 7e-27 229193005348 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 229193005349 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 229193005350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193005351 FeS/SAM binding site; other site 229193005352 HMMPfam match to entry PF04055 Radical_SAM, E-value 6.9e-26 229193005353 putative MFS family transporter protein; Provisional; Region: PRK03633 229193005354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193005355 putative substrate translocation pore; other site 229193005356 probable transmembrane helix predicted by TMHMM2.0 229193005357 probable transmembrane helix predicted by TMHMM2.0 229193005358 probable transmembrane helix predicted by TMHMM2.0 229193005359 probable transmembrane helix predicted by TMHMM2.0 229193005360 probable transmembrane helix predicted by TMHMM2.0 229193005361 probable transmembrane helix predicted by TMHMM2.0 229193005362 probable transmembrane helix predicted by TMHMM2.0 229193005363 probable transmembrane helix predicted by TMHMM2.0 229193005364 probable transmembrane helix predicted by TMHMM2.0 229193005365 probable transmembrane helix predicted by TMHMM2.0 229193005366 probable transmembrane helix predicted by TMHMM2.0 229193005367 probable transmembrane helix predicted by TMHMM2.0 229193005368 seryl-tRNA synthetase; Provisional; Region: PRK05431 229193005369 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 229193005370 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 229193005371 dimer interface [polypeptide binding]; other site 229193005372 active site 229193005373 motif 1; other site 229193005374 motif 2; other site 229193005375 motif 3; other site 229193005376 recombination factor protein RarA; Reviewed; Region: PRK13342 229193005377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193005378 Walker A motif; other site 229193005379 ATP binding site [chemical binding]; other site 229193005380 Walker B motif; other site 229193005381 arginine finger; other site 229193005382 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 229193005383 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 229193005384 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 229193005385 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 229193005386 DNA translocase FtsK; Provisional; Region: PRK10263 229193005387 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 229193005388 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 229193005389 probable transmembrane helix predicted by TMHMM2.0 229193005390 probable transmembrane helix predicted by TMHMM2.0 229193005391 probable transmembrane helix predicted by TMHMM2.0 229193005392 probable transmembrane helix predicted by TMHMM2.0 229193005393 probable transmembrane helix predicted by TMHMM2.0 229193005394 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 229193005395 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 229193005396 putative DNA binding site [nucleotide binding]; other site 229193005397 putative Zn2+ binding site [ion binding]; other site 229193005398 AsnC family; Region: AsnC_trans_reg; pfam01037 229193005399 thioredoxin reductase; Provisional; Region: PRK10262 229193005400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 229193005401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 229193005402 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 229193005403 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 229193005404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193005405 Walker A/P-loop; other site 229193005406 ATP binding site [chemical binding]; other site 229193005407 Q-loop/lid; other site 229193005408 ABC transporter signature motif; other site 229193005409 Walker B; other site 229193005410 D-loop; other site 229193005411 H-loop/switch region; other site 229193005412 probable transmembrane helix predicted by TMHMM2.0 229193005413 probable transmembrane helix predicted by TMHMM2.0 229193005414 probable transmembrane helix predicted by TMHMM2.0 229193005415 probable transmembrane helix predicted by TMHMM2.0 229193005416 probable transmembrane helix predicted by TMHMM2.0 229193005417 probable transmembrane helix predicted by TMHMM2.0 229193005418 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 229193005419 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 229193005420 Walker A/P-loop; other site 229193005421 ATP binding site [chemical binding]; other site 229193005422 Q-loop/lid; other site 229193005423 ABC transporter signature motif; other site 229193005424 Walker B; other site 229193005425 D-loop; other site 229193005426 H-loop/switch region; other site 229193005427 probable transmembrane helix predicted by TMHMM2.0 229193005428 probable transmembrane helix predicted by TMHMM2.0 229193005429 probable transmembrane helix predicted by TMHMM2.0 229193005430 probable transmembrane helix predicted by TMHMM2.0 229193005431 probable transmembrane helix predicted by TMHMM2.0 229193005432 probable transmembrane helix predicted by TMHMM2.0 229193005433 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 229193005434 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 229193005435 rRNA binding site [nucleotide binding]; other site 229193005436 predicted 30S ribosome binding site; other site 229193005437 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193005438 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 229193005439 Clp amino terminal domain; Region: Clp_N; pfam02861 229193005440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193005441 Walker A motif; other site 229193005442 ATP binding site [chemical binding]; other site 229193005443 Walker B motif; other site 229193005444 arginine finger; other site 229193005445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193005446 Walker A motif; other site 229193005447 ATP binding site [chemical binding]; other site 229193005448 Walker B motif; other site 229193005449 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 229193005450 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 229193005451 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 229193005452 DNA-binding site [nucleotide binding]; DNA binding site 229193005453 RNA-binding motif; other site 229193005454 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 229193005455 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 229193005456 Walker A/P-loop; other site 229193005457 ATP binding site [chemical binding]; other site 229193005458 Q-loop/lid; other site 229193005459 ABC transporter signature motif; other site 229193005460 Walker B; other site 229193005461 D-loop; other site 229193005462 H-loop/switch region; other site 229193005463 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 229193005464 FtsX-like permease family; Region: FtsX; pfam02687 229193005465 probable transmembrane helix predicted by TMHMM2.0 229193005466 probable transmembrane helix predicted by TMHMM2.0 229193005467 probable transmembrane helix predicted by TMHMM2.0 229193005468 probable transmembrane helix predicted by TMHMM2.0 229193005469 probable transmembrane helix predicted by TMHMM2.0 229193005470 BlastProDom match to entry PD039360 sp_Q57585_Y121_METJA, E-value 9e-08 229193005471 macrolide transporter subunit MacA; Provisional; Region: PRK11578 229193005472 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 229193005473 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193005474 probable transmembrane helix predicted by TMHMM2.0 229193005475 Protein of unknown function (DUF535); Region: DUF535; pfam04393 229193005476 HMMPfam match to entry PF04393 DUF535, E-value 2.6e-79 229193005477 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 229193005478 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 229193005479 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 229193005480 putative active site [active] 229193005481 putative metal-binding site [ion binding]; other site 229193005482 Predicted membrane protein [Function unknown]; Region: COG2431 229193005483 probable transmembrane helix predicted by TMHMM2.0 229193005484 probable transmembrane helix predicted by TMHMM2.0 229193005485 probable transmembrane helix predicted by TMHMM2.0 229193005486 probable transmembrane helix predicted by TMHMM2.0 229193005487 probable transmembrane helix predicted by TMHMM2.0 229193005488 probable transmembrane helix predicted by TMHMM2.0 229193005489 probable transmembrane helix predicted by TMHMM2.0 229193005490 probable transmembrane helix predicted by TMHMM2.0 229193005491 hybrid cluster protein; Provisional; Region: PRK05290 229193005492 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 229193005493 ACS interaction site; other site 229193005494 CODH interaction site; other site 229193005495 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 229193005496 hybrid metal cluster; other site 229193005497 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 229193005498 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 229193005499 FAD binding pocket [chemical binding]; other site 229193005500 FAD binding motif [chemical binding]; other site 229193005501 phosphate binding motif [ion binding]; other site 229193005502 beta-alpha-beta structure motif; other site 229193005503 NAD binding pocket [chemical binding]; other site 229193005504 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 229193005505 catalytic loop [active] 229193005506 iron binding site [ion binding]; other site 229193005507 pyruvate dehydrogenase; Provisional; Region: PRK09124 229193005508 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 229193005509 PYR/PP interface [polypeptide binding]; other site 229193005510 dimer interface [polypeptide binding]; other site 229193005511 tetramer interface [polypeptide binding]; other site 229193005512 TPP binding site [chemical binding]; other site 229193005513 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 229193005514 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 229193005515 TPP-binding site [chemical binding]; other site 229193005516 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 229193005517 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 229193005518 tetramer interface [polypeptide binding]; other site 229193005519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193005520 catalytic residue [active] 229193005521 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 229193005522 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 229193005523 putative NAD(P) binding site [chemical binding]; other site 229193005524 putative active site [active] 229193005525 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 229193005526 probable transmembrane helix predicted by TMHMM2.0 229193005527 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 229193005528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 229193005529 NAD(P) binding site [chemical binding]; other site 229193005530 active site 229193005531 putative lipoprotein; Provisional; Region: PRK10533 229193005532 chorismate mutase; Provisional; Region: PRK08055 229193005533 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 229193005534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193005535 Walker A/P-loop; other site 229193005536 ATP binding site [chemical binding]; other site 229193005537 Q-loop/lid; other site 229193005538 ABC transporter signature motif; other site 229193005539 Walker B; other site 229193005540 D-loop; other site 229193005541 H-loop/switch region; other site 229193005542 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 229193005543 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193005544 substrate binding pocket [chemical binding]; other site 229193005545 membrane-bound complex binding site; other site 229193005546 hinge residues; other site 229193005547 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 229193005548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193005549 dimer interface [polypeptide binding]; other site 229193005550 conserved gate region; other site 229193005551 putative PBP binding loops; other site 229193005552 ABC-ATPase subunit interface; other site 229193005553 probable transmembrane helix predicted by TMHMM2.0 229193005554 probable transmembrane helix predicted by TMHMM2.0 229193005555 probable transmembrane helix predicted by TMHMM2.0 229193005556 probable transmembrane helix predicted by TMHMM2.0 229193005557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193005558 dimer interface [polypeptide binding]; other site 229193005559 conserved gate region; other site 229193005560 putative PBP binding loops; other site 229193005561 ABC-ATPase subunit interface; other site 229193005562 probable transmembrane helix predicted by TMHMM2.0 229193005563 probable transmembrane helix predicted by TMHMM2.0 229193005564 probable transmembrane helix predicted by TMHMM2.0 229193005565 probable transmembrane helix predicted by TMHMM2.0 229193005566 probable transmembrane helix predicted by TMHMM2.0 229193005567 EamA-like transporter family; Region: EamA; pfam00892 229193005568 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 229193005569 probable transmembrane helix predicted by TMHMM2.0 229193005570 probable transmembrane helix predicted by TMHMM2.0 229193005571 probable transmembrane helix predicted by TMHMM2.0 229193005572 probable transmembrane helix predicted by TMHMM2.0 229193005573 probable transmembrane helix predicted by TMHMM2.0 229193005574 probable transmembrane helix predicted by TMHMM2.0 229193005575 probable transmembrane helix predicted by TMHMM2.0 229193005576 probable transmembrane helix predicted by TMHMM2.0 229193005577 probable transmembrane helix predicted by TMHMM2.0 229193005578 probable transmembrane helix predicted by TMHMM2.0 229193005579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 229193005580 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 229193005581 Nicotianamine synthase protein; Region: NAS; cl17658 229193005582 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 229193005583 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 229193005584 Walker A/P-loop; other site 229193005585 ATP binding site [chemical binding]; other site 229193005586 Q-loop/lid; other site 229193005587 ABC transporter signature motif; other site 229193005588 Walker B; other site 229193005589 D-loop; other site 229193005590 H-loop/switch region; other site 229193005591 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193005592 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 229193005593 putative PBP binding regions; other site 229193005594 ABC-ATPase subunit interface; other site 229193005595 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 229193005596 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 229193005597 putative ligand binding residues [chemical binding]; other site 229193005598 probable transmembrane helix predicted by TMHMM2.0 229193005599 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 229193005600 SPFH domain / Band 7 family; Region: Band_7; pfam01145 229193005601 probable transmembrane helix predicted by TMHMM2.0 229193005602 probable transmembrane helix predicted by TMHMM2.0 229193005603 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 229193005604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193005605 substrate binding pocket [chemical binding]; other site 229193005606 membrane-bound complex binding site; other site 229193005607 hinge residues; other site 229193005608 probable transmembrane helix predicted by TMHMM2.0 229193005609 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 229193005610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193005611 S-adenosylmethionine binding site [chemical binding]; other site 229193005612 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 229193005613 probable transmembrane helix predicted by TMHMM2.0 229193005614 probable transmembrane helix predicted by TMHMM2.0 229193005615 probable transmembrane helix predicted by TMHMM2.0 229193005616 probable transmembrane helix predicted by TMHMM2.0 229193005617 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 229193005618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193005619 dimer interface [polypeptide binding]; other site 229193005620 conserved gate region; other site 229193005621 putative PBP binding loops; other site 229193005622 ABC-ATPase subunit interface; other site 229193005623 probable transmembrane helix predicted by TMHMM2.0 229193005624 probable transmembrane helix predicted by TMHMM2.0 229193005625 probable transmembrane helix predicted by TMHMM2.0 229193005626 probable transmembrane helix predicted by TMHMM2.0 229193005627 probable transmembrane helix predicted by TMHMM2.0 229193005628 probable transmembrane helix predicted by TMHMM2.0 229193005629 probable transmembrane helix predicted by TMHMM2.0 229193005630 probable transmembrane helix predicted by TMHMM2.0 229193005631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193005632 dimer interface [polypeptide binding]; other site 229193005633 conserved gate region; other site 229193005634 putative PBP binding loops; other site 229193005635 ABC-ATPase subunit interface; other site 229193005636 probable transmembrane helix predicted by TMHMM2.0 229193005637 probable transmembrane helix predicted by TMHMM2.0 229193005638 probable transmembrane helix predicted by TMHMM2.0 229193005639 probable transmembrane helix predicted by TMHMM2.0 229193005640 probable transmembrane helix predicted by TMHMM2.0 229193005641 probable transmembrane helix predicted by TMHMM2.0 229193005642 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 229193005643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193005644 Walker A/P-loop; other site 229193005645 ATP binding site [chemical binding]; other site 229193005646 Q-loop/lid; other site 229193005647 ABC transporter signature motif; other site 229193005648 Walker B; other site 229193005649 D-loop; other site 229193005650 H-loop/switch region; other site 229193005651 TOBE domain; Region: TOBE_2; pfam08402 229193005652 BlastProDom match to entry PD039360 sp_Q57585_Y121_METJA, E-value 6e-07 229193005653 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 229193005654 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 229193005655 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 229193005656 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 229193005657 probable transmembrane helix predicted by TMHMM2.0 229193005658 probable transmembrane helix predicted by TMHMM2.0 229193005659 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 229193005660 GSH binding site [chemical binding]; other site 229193005661 catalytic residues [active] 229193005662 putative transporter; Provisional; Region: PRK04972 229193005663 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 229193005664 TrkA-C domain; Region: TrkA_C; pfam02080 229193005665 TrkA-C domain; Region: TrkA_C; pfam02080 229193005666 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 229193005667 probable transmembrane helix predicted by TMHMM2.0 229193005668 probable transmembrane helix predicted by TMHMM2.0 229193005669 probable transmembrane helix predicted by TMHMM2.0 229193005670 probable transmembrane helix predicted by TMHMM2.0 229193005671 probable transmembrane helix predicted by TMHMM2.0 229193005672 probable transmembrane helix predicted by TMHMM2.0 229193005673 probable transmembrane helix predicted by TMHMM2.0 229193005674 probable transmembrane helix predicted by TMHMM2.0 229193005675 probable transmembrane helix predicted by TMHMM2.0 229193005676 probable transmembrane helix predicted by TMHMM2.0 229193005677 probable transmembrane helix predicted by TMHMM2.0 229193005678 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 229193005679 active site 229193005680 probable transmembrane helix predicted by TMHMM2.0 229193005681 probable transmembrane helix predicted by TMHMM2.0 229193005682 probable transmembrane helix predicted by TMHMM2.0 229193005683 probable transmembrane helix predicted by TMHMM2.0 229193005684 probable transmembrane helix predicted by TMHMM2.0 229193005685 probable transmembrane helix predicted by TMHMM2.0 229193005686 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 229193005687 active site 229193005688 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 229193005689 probable transmembrane helix predicted by TMHMM2.0 229193005690 probable transmembrane helix predicted by TMHMM2.0 229193005691 probable transmembrane helix predicted by TMHMM2.0 229193005692 probable transmembrane helix predicted by TMHMM2.0 229193005693 probable transmembrane helix predicted by TMHMM2.0 229193005694 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 229193005695 intersubunit interface [polypeptide binding]; other site 229193005696 active site 229193005697 catalytic residue [active] 229193005698 HMMTigr match to entry TIGR00126 deoC, E-value 5.3e-83 229193005699 BlastProDom match to entry PD005801 sp_P44430_DEOC_HAEIN, E-value 9e-64 229193005700 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 229193005701 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 229193005702 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 229193005703 serine transporter; Region: stp; TIGR00814 229193005704 BlastProDom match to entry PD008790 sp_P36559_SDAC_ECOLI, E-value 0.0 229193005705 probable transmembrane helix predicted by TMHMM2.0 229193005706 BlastProDom match to entry PD007729 sp_O84825_O84825_CHLTR, E-value 5e-07 229193005707 probable transmembrane helix predicted by TMHMM2.0 229193005708 probable transmembrane helix predicted by TMHMM2.0 229193005709 probable transmembrane helix predicted by TMHMM2.0 229193005710 probable transmembrane helix predicted by TMHMM2.0 229193005711 probable transmembrane helix predicted by TMHMM2.0 229193005712 probable transmembrane helix predicted by TMHMM2.0 229193005713 probable transmembrane helix predicted by TMHMM2.0 229193005714 probable transmembrane helix predicted by TMHMM2.0 229193005715 probable transmembrane helix predicted by TMHMM2.0 229193005716 probable transmembrane helix predicted by TMHMM2.0 229193005717 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 229193005718 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 229193005719 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 229193005720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193005721 dimer interface [polypeptide binding]; other site 229193005722 conserved gate region; other site 229193005723 ABC-ATPase subunit interface; other site 229193005724 probable transmembrane helix predicted by TMHMM2.0 229193005725 probable transmembrane helix predicted by TMHMM2.0 229193005726 probable transmembrane helix predicted by TMHMM2.0 229193005727 probable transmembrane helix predicted by TMHMM2.0 229193005728 probable transmembrane helix predicted by TMHMM2.0 229193005729 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 229193005730 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 229193005731 Walker A/P-loop; other site 229193005732 ATP binding site [chemical binding]; other site 229193005733 Q-loop/lid; other site 229193005734 ABC transporter signature motif; other site 229193005735 Walker B; other site 229193005736 D-loop; other site 229193005737 H-loop/switch region; other site 229193005738 NIL domain; Region: NIL; pfam09383 229193005739 BlastProDom match to entry PD039360 sp_Q57585_Y121_METJA, E-value 4e-07 229193005740 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 229193005741 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 229193005742 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 229193005743 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 229193005744 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 229193005745 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 229193005746 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 229193005747 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 229193005748 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 229193005749 putative C-terminal domain interface [polypeptide binding]; other site 229193005750 putative GSH binding site (G-site) [chemical binding]; other site 229193005751 putative dimer interface [polypeptide binding]; other site 229193005752 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 229193005753 putative N-terminal domain interface [polypeptide binding]; other site 229193005754 putative dimer interface [polypeptide binding]; other site 229193005755 putative substrate binding pocket (H-site) [chemical binding]; other site 229193005756 putative outer membrane receptor; Provisional; Region: PRK13513 229193005757 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 229193005758 N-terminal plug; other site 229193005759 ligand-binding site [chemical binding]; other site 229193005760 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 229193005761 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 229193005762 Walker A/P-loop; other site 229193005763 ATP binding site [chemical binding]; other site 229193005764 Q-loop/lid; other site 229193005765 ABC transporter signature motif; other site 229193005766 Walker B; other site 229193005767 D-loop; other site 229193005768 H-loop/switch region; other site 229193005769 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 229193005770 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 229193005771 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193005772 ABC-ATPase subunit interface; other site 229193005773 dimer interface [polypeptide binding]; other site 229193005774 putative PBP binding regions; other site 229193005775 probable transmembrane helix predicted by TMHMM2.0 229193005776 probable transmembrane helix predicted by TMHMM2.0 229193005777 probable transmembrane helix predicted by TMHMM2.0 229193005778 probable transmembrane helix predicted by TMHMM2.0 229193005779 probable transmembrane helix predicted by TMHMM2.0 229193005780 probable transmembrane helix predicted by TMHMM2.0 229193005781 probable transmembrane helix predicted by TMHMM2.0 229193005782 probable transmembrane helix predicted by TMHMM2.0 229193005783 probable transmembrane helix predicted by TMHMM2.0 229193005784 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 229193005785 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 229193005786 putative ligand binding residues [chemical binding]; other site 229193005787 probable transmembrane helix predicted by TMHMM2.0 229193005788 lysine transporter; Provisional; Region: PRK10836 229193005789 probable transmembrane helix predicted by TMHMM2.0 229193005790 probable transmembrane helix predicted by TMHMM2.0 229193005791 probable transmembrane helix predicted by TMHMM2.0 229193005792 probable transmembrane helix predicted by TMHMM2.0 229193005793 probable transmembrane helix predicted by TMHMM2.0 229193005794 probable transmembrane helix predicted by TMHMM2.0 229193005795 probable transmembrane helix predicted by TMHMM2.0 229193005796 probable transmembrane helix predicted by TMHMM2.0 229193005797 probable transmembrane helix predicted by TMHMM2.0 229193005798 probable transmembrane helix predicted by TMHMM2.0 229193005799 probable transmembrane helix predicted by TMHMM2.0 229193005800 probable transmembrane helix predicted by TMHMM2.0 229193005801 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 229193005802 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193005803 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 229193005804 putative dimerization interface [polypeptide binding]; other site 229193005805 Predicted membrane protein [Function unknown]; Region: COG2855 229193005806 probable transmembrane helix predicted by TMHMM2.0 229193005807 probable transmembrane helix predicted by TMHMM2.0 229193005808 probable transmembrane helix predicted by TMHMM2.0 229193005809 probable transmembrane helix predicted by TMHMM2.0 229193005810 probable transmembrane helix predicted by TMHMM2.0 229193005811 probable transmembrane helix predicted by TMHMM2.0 229193005812 probable transmembrane helix predicted by TMHMM2.0 229193005813 probable transmembrane helix predicted by TMHMM2.0 229193005814 probable transmembrane helix predicted by TMHMM2.0 229193005815 probable transmembrane helix predicted by TMHMM2.0 229193005816 endonuclease IV; Provisional; Region: PRK01060 229193005817 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 229193005818 AP (apurinic/apyrimidinic) site pocket; other site 229193005819 DNA interaction; other site 229193005820 Metal-binding active site; metal-binding site 229193005821 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 229193005822 PapC N-terminal domain; Region: PapC_N; pfam13954 229193005823 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 229193005824 PapC C-terminal domain; Region: PapC_C; pfam13953 229193005825 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 229193005826 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193005827 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 229193005828 probable transmembrane helix predicted by TMHMM2.0 229193005829 probable transmembrane helix predicted by TMHMM2.0 229193005830 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 229193005831 DNA binding site [nucleotide binding] 229193005832 probable transmembrane helix predicted by TMHMM2.0 229193005833 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 229193005834 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 229193005835 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 229193005836 active site 229193005837 P-loop; other site 229193005838 phosphorylation site [posttranslational modification] 229193005839 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 229193005840 probable transmembrane helix predicted by TMHMM2.0 229193005841 probable transmembrane helix predicted by TMHMM2.0 229193005842 probable transmembrane helix predicted by TMHMM2.0 229193005843 probable transmembrane helix predicted by TMHMM2.0 229193005844 probable transmembrane helix predicted by TMHMM2.0 229193005845 probable transmembrane helix predicted by TMHMM2.0 229193005846 probable transmembrane helix predicted by TMHMM2.0 229193005847 probable transmembrane helix predicted by TMHMM2.0 229193005848 probable transmembrane helix predicted by TMHMM2.0 229193005849 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 229193005850 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 229193005851 putative substrate binding site [chemical binding]; other site 229193005852 putative ATP binding site [chemical binding]; other site 229193005853 BlastProDom match to entry PD023180 sp_P23539_K1PF_ECOLI, E-value 4e-22 229193005854 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 229193005855 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 229193005856 active site 229193005857 phosphorylation site [posttranslational modification] 229193005858 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 229193005859 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 229193005860 dimerization domain swap beta strand [polypeptide binding]; other site 229193005861 regulatory protein interface [polypeptide binding]; other site 229193005862 active site 229193005863 regulatory phosphorylation site [posttranslational modification]; other site 229193005864 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 229193005865 nudix motif; other site 229193005866 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193005867 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193005868 TM-ABC transporter signature motif; other site 229193005869 probable transmembrane helix predicted by TMHMM2.0 229193005870 probable transmembrane helix predicted by TMHMM2.0 229193005871 probable transmembrane helix predicted by TMHMM2.0 229193005872 probable transmembrane helix predicted by TMHMM2.0 229193005873 probable transmembrane helix predicted by TMHMM2.0 229193005874 probable transmembrane helix predicted by TMHMM2.0 229193005875 probable transmembrane helix predicted by TMHMM2.0 229193005876 probable transmembrane helix predicted by TMHMM2.0 229193005877 probable transmembrane helix predicted by TMHMM2.0 229193005878 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 229193005879 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193005880 Walker A/P-loop; other site 229193005881 ATP binding site [chemical binding]; other site 229193005882 Q-loop/lid; other site 229193005883 ABC transporter signature motif; other site 229193005884 Walker B; other site 229193005885 D-loop; other site 229193005886 H-loop/switch region; other site 229193005887 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193005888 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 229193005889 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 229193005890 ligand binding site [chemical binding]; other site 229193005891 probable transmembrane helix predicted by TMHMM2.0 229193005892 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 229193005893 tetramer (dimer of dimers) interface [polypeptide binding]; other site 229193005894 active site 229193005895 dimer interface [polypeptide binding]; other site 229193005896 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 229193005897 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 229193005898 N- and C-terminal domain interface [polypeptide binding]; other site 229193005899 active site 229193005900 MgATP binding site [chemical binding]; other site 229193005901 catalytic site [active] 229193005902 metal binding site [ion binding]; metal-binding site 229193005903 xylulose binding site [chemical binding]; other site 229193005904 homodimer interface [polypeptide binding]; other site 229193005905 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 229193005906 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 229193005907 tetramerization interface [polypeptide binding]; other site 229193005908 NAD(P) binding site [chemical binding]; other site 229193005909 catalytic residues [active] 229193005910 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 229193005911 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 229193005912 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 229193005913 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 229193005914 ligand binding site [chemical binding]; other site 229193005915 NAD binding site [chemical binding]; other site 229193005916 catalytic site [active] 229193005917 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 229193005918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 229193005919 NAD(P) binding site [chemical binding]; other site 229193005920 active site 229193005921 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 229193005922 aromatic amino acid transport protein; Region: araaP; TIGR00837 229193005923 probable transmembrane helix predicted by TMHMM2.0 229193005924 BlastProDom match to entry PD007729 sp_Q9HTD2_Q9HTD2_PSEAE, E-value 1e-90 229193005925 probable transmembrane helix predicted by TMHMM2.0 229193005926 probable transmembrane helix predicted by TMHMM2.0 229193005927 probable transmembrane helix predicted by TMHMM2.0 229193005928 probable transmembrane helix predicted by TMHMM2.0 229193005929 probable transmembrane helix predicted by TMHMM2.0 229193005930 probable transmembrane helix predicted by TMHMM2.0 229193005931 probable transmembrane helix predicted by TMHMM2.0 229193005932 probable transmembrane helix predicted by TMHMM2.0 229193005933 elongation factor P; Provisional; Region: PRK04542 229193005934 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 229193005935 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 229193005936 RNA binding site [nucleotide binding]; other site 229193005937 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 229193005938 RNA binding site [nucleotide binding]; other site 229193005939 mannonate dehydratase; Provisional; Region: PRK03906 229193005940 mannonate dehydratase; Region: uxuA; TIGR00695 229193005941 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 229193005942 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 229193005943 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 229193005944 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 229193005945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 229193005946 DNA-binding site [nucleotide binding]; DNA binding site 229193005947 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 229193005948 probable transmembrane helix predicted by TMHMM2.0 229193005949 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 229193005950 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 229193005951 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 229193005952 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 229193005953 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 229193005954 active site 229193005955 probable transmembrane helix predicted by TMHMM2.0 229193005956 probable transmembrane helix predicted by TMHMM2.0 229193005957 probable transmembrane helix predicted by TMHMM2.0 229193005958 probable transmembrane helix predicted by TMHMM2.0 229193005959 probable transmembrane helix predicted by TMHMM2.0 229193005960 probable transmembrane helix predicted by TMHMM2.0 229193005961 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 229193005962 NlpC/P60 family; Region: NLPC_P60; pfam00877 229193005963 phage resistance protein; Provisional; Region: PRK10551 229193005964 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 229193005965 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 229193005966 probable transmembrane helix predicted by TMHMM2.0 229193005967 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 229193005968 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 229193005969 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 229193005970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193005971 dimer interface [polypeptide binding]; other site 229193005972 conserved gate region; other site 229193005973 putative PBP binding loops; other site 229193005974 ABC-ATPase subunit interface; other site 229193005975 probable transmembrane helix predicted by TMHMM2.0 229193005976 probable transmembrane helix predicted by TMHMM2.0 229193005977 probable transmembrane helix predicted by TMHMM2.0 229193005978 probable transmembrane helix predicted by TMHMM2.0 229193005979 probable transmembrane helix predicted by TMHMM2.0 229193005980 probable transmembrane helix predicted by TMHMM2.0 229193005981 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 229193005982 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 229193005983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193005984 dimer interface [polypeptide binding]; other site 229193005985 conserved gate region; other site 229193005986 putative PBP binding loops; other site 229193005987 ABC-ATPase subunit interface; other site 229193005988 probable transmembrane helix predicted by TMHMM2.0 229193005989 probable transmembrane helix predicted by TMHMM2.0 229193005990 probable transmembrane helix predicted by TMHMM2.0 229193005991 probable transmembrane helix predicted by TMHMM2.0 229193005992 probable transmembrane helix predicted by TMHMM2.0 229193005993 probable transmembrane helix predicted by TMHMM2.0 229193005994 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 229193005995 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193005996 Walker A/P-loop; other site 229193005997 ATP binding site [chemical binding]; other site 229193005998 Q-loop/lid; other site 229193005999 ABC transporter signature motif; other site 229193006000 Walker B; other site 229193006001 D-loop; other site 229193006002 H-loop/switch region; other site 229193006003 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 229193006004 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193006005 Walker A/P-loop; other site 229193006006 ATP binding site [chemical binding]; other site 229193006007 Q-loop/lid; other site 229193006008 ABC transporter signature motif; other site 229193006009 Walker B; other site 229193006010 D-loop; other site 229193006011 H-loop/switch region; other site 229193006012 hypothetical protein; Provisional; Region: PRK11835 229193006013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193006014 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 229193006015 putative substrate translocation pore; other site 229193006016 probable transmembrane helix predicted by TMHMM2.0 229193006017 probable transmembrane helix predicted by TMHMM2.0 229193006018 probable transmembrane helix predicted by TMHMM2.0 229193006019 probable transmembrane helix predicted by TMHMM2.0 229193006020 probable transmembrane helix predicted by TMHMM2.0 229193006021 probable transmembrane helix predicted by TMHMM2.0 229193006022 probable transmembrane helix predicted by TMHMM2.0 229193006023 probable transmembrane helix predicted by TMHMM2.0 229193006024 probable transmembrane helix predicted by TMHMM2.0 229193006025 probable transmembrane helix predicted by TMHMM2.0 229193006026 probable transmembrane helix predicted by TMHMM2.0 229193006027 probable transmembrane helix predicted by TMHMM2.0 229193006028 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 229193006029 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 229193006030 RNA binding surface [nucleotide binding]; other site 229193006031 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 229193006032 active site 229193006033 uracil binding [chemical binding]; other site 229193006034 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 229193006035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 229193006036 ATP binding site [chemical binding]; other site 229193006037 putative Mg++ binding site [ion binding]; other site 229193006038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193006039 nucleotide binding region [chemical binding]; other site 229193006040 ATP-binding site [chemical binding]; other site 229193006041 Double zinc ribbon; Region: DZR; pfam12773 229193006042 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 229193006043 5S rRNA interface [nucleotide binding]; other site 229193006044 CTC domain interface [polypeptide binding]; other site 229193006045 L16 interface [polypeptide binding]; other site 229193006046 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193006047 outer membrane protein A; Reviewed; Region: PRK10808 229193006048 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 229193006049 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 229193006050 ligand binding site [chemical binding]; other site 229193006051 SOS-response cell division inhibitor, blocks FtsZ ring formation [Cell division and chromosome partitioning]; Region: SulA; COG5404 229193006052 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 229193006053 TfoX C-terminal domain; Region: TfoX_C; pfam04994 229193006054 probable transmembrane helix predicted by TMHMM2.0 229193006055 TIGR01666 family membrane protein; Region: YCCS 229193006056 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 229193006057 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 229193006058 probable transmembrane helix predicted by TMHMM2.0 229193006059 probable transmembrane helix predicted by TMHMM2.0 229193006060 probable transmembrane helix predicted by TMHMM2.0 229193006061 probable transmembrane helix predicted by TMHMM2.0 229193006062 probable transmembrane helix predicted by TMHMM2.0 229193006063 probable transmembrane helix predicted by TMHMM2.0 229193006064 probable transmembrane helix predicted by TMHMM2.0 229193006065 probable transmembrane helix predicted by TMHMM2.0 229193006066 Predicted membrane protein [Function unknown]; Region: COG3304 229193006067 Domain of unknown function (DUF307); Region: DUF307; pfam03733 229193006068 probable transmembrane helix predicted by TMHMM2.0 229193006069 probable transmembrane helix predicted by TMHMM2.0 229193006070 probable transmembrane helix predicted by TMHMM2.0 229193006071 DNA helicase IV; Provisional; Region: helD; PRK11054 229193006072 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 229193006073 Part of AAA domain; Region: AAA_19; pfam13245 229193006074 Family description; Region: UvrD_C_2; pfam13538 229193006075 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 229193006076 active site 229193006077 dimer interfaces [polypeptide binding]; other site 229193006078 catalytic residues [active] 229193006079 hypothetical protein; Provisional; Region: PRK03641 229193006080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 229193006081 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 229193006082 heat shock protein HspQ; Provisional; Region: PRK14129 229193006083 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 229193006084 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 229193006085 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 229193006086 putative RNA binding site [nucleotide binding]; other site 229193006087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193006088 S-adenosylmethionine binding site [chemical binding]; other site 229193006089 acylphosphatase; Provisional; Region: PRK14426 229193006090 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 229193006091 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 229193006092 HMMPfam match to entry PF04358 DsrC, E-value 1e-75 229193006093 Integrase core domain; Region: rve; pfam00665 229193006094 highly similar to Yersinia pseudotuberculosis cnf. CDS contains a nonsense mutation in codon 121 and a frameshift mutation following codon 214 and it is also disrupted by the insertion of IS100 229193006095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193006096 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193006097 DNA-binding interface [nucleotide binding]; DNA binding site 229193006098 Integrase core domain; Region: rve; pfam00665 229193006099 transposase/IS protein; Provisional; Region: PRK09183 229193006100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193006101 Walker A motif; other site 229193006102 ATP binding site [chemical binding]; other site 229193006103 Walker B motif; other site 229193006104 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 229193006105 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 229193006106 FAD binding domain; Region: FAD_binding_4; pfam01565 229193006107 short chain dehydrogenase; Provisional; Region: PRK06172 229193006108 classical (c) SDRs; Region: SDR_c; cd05233 229193006109 NAD(P) binding site [chemical binding]; other site 229193006110 active site 229193006111 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 229193006112 active site 2 [active] 229193006113 dimer interface [polypeptide binding]; other site 229193006114 active site 1 [active] 229193006115 BlastProDom match to entry PD005671 sp_P32205_FABZ_YEREN, E-value 5e-58 229193006116 BlastProDom match to entry PD005671 sp_Q9HXY7_FABZ_PSEAE, E-value 7e-13 229193006117 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 229193006118 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 229193006119 dimer interface [polypeptide binding]; other site 229193006120 active site 229193006121 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 229193006122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 229193006123 NAD(P) binding site [chemical binding]; other site 229193006124 active site 229193006125 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 229193006126 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 229193006127 dimer interface [polypeptide binding]; other site 229193006128 active site 229193006129 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 229193006130 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 229193006131 substrate binding site [chemical binding]; other site 229193006132 oxyanion hole (OAH) forming residues; other site 229193006133 trimer interface [polypeptide binding]; other site 229193006134 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 229193006135 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 229193006136 substrate binding site [chemical binding]; other site 229193006137 oxyanion hole (OAH) forming residues; other site 229193006138 trimer interface [polypeptide binding]; other site 229193006139 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 229193006140 classical (c) SDRs; Region: SDR_c; cd05233 229193006141 NAD(P) binding site [chemical binding]; other site 229193006142 active site 229193006143 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 229193006144 acyl carrier protein; Validated; Region: PRK07117 229193006145 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 229193006146 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 229193006147 probable transmembrane helix predicted by TMHMM2.0 229193006148 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 229193006149 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 229193006150 Protein of unknown function (DUF877); Region: DUF877; pfam05943 229193006151 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 229193006152 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 229193006153 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 229193006154 probable transmembrane helix predicted by TMHMM2.0 229193006155 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 229193006156 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 229193006157 ligand binding site [chemical binding]; other site 229193006158 probable transmembrane helix predicted by TMHMM2.0 229193006159 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 229193006160 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 229193006161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193006162 Walker A motif; other site 229193006163 ATP binding site [chemical binding]; other site 229193006164 Walker B motif; other site 229193006165 arginine finger; other site 229193006166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193006167 Walker A motif; other site 229193006168 ATP binding site [chemical binding]; other site 229193006169 Walker B motif; other site 229193006170 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 229193006171 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 229193006172 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 229193006173 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 229193006174 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 229193006175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 229193006176 Peptidase family M23; Region: Peptidase_M23; pfam01551 229193006177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 229193006178 Peptidase family M23; Region: Peptidase_M23; pfam01551 229193006179 Winged helix-turn helix; Region: HTH_33; pfam13592 229193006180 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 229193006181 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 229193006182 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 229193006183 probable transmembrane helix predicted by TMHMM2.0 229193006184 probable transmembrane helix predicted by TMHMM2.0 229193006185 probable transmembrane helix predicted by TMHMM2.0 229193006186 PAAR motif; Region: PAAR_motif; pfam05488 229193006187 probable transmembrane helix predicted by TMHMM2.0 229193006188 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 229193006189 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 229193006190 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 229193006191 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 229193006192 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 229193006193 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 229193006194 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 229193006195 ImpA domain protein; Region: DUF3702; pfam12486 229193006196 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 229193006197 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 229193006198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193006199 Walker A/P-loop; other site 229193006200 ATP binding site [chemical binding]; other site 229193006201 Q-loop/lid; other site 229193006202 ABC transporter signature motif; other site 229193006203 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 229193006204 Walker B; other site 229193006205 D-loop; other site 229193006206 H-loop/switch region; other site 229193006207 ABC transporter; Region: ABC_tran_2; pfam12848 229193006208 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 229193006209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193006210 MULE transposase domain; Region: MULE; pfam10551 229193006211 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 229193006212 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 229193006213 ATP binding site [chemical binding]; other site 229193006214 substrate interface [chemical binding]; other site 229193006215 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 229193006216 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 229193006217 dimer interface [polypeptide binding]; other site 229193006218 putative functional site; other site 229193006219 putative MPT binding site; other site 229193006220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193006221 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 229193006222 FeS/SAM binding site; other site 229193006223 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 229193006224 HMMPfam match to entry PF04055 Radical_SAM, E-value 3e-11 229193006225 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 229193006226 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 229193006227 Walker A/P-loop; other site 229193006228 ATP binding site [chemical binding]; other site 229193006229 Q-loop/lid; other site 229193006230 ABC transporter signature motif; other site 229193006231 Walker B; other site 229193006232 D-loop; other site 229193006233 H-loop/switch region; other site 229193006234 BlastProDom match to entry PD039360 sp_O27709_O27709_METTH, E-value 4e-13 229193006235 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 229193006236 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193006237 probable transmembrane helix predicted by TMHMM2.0 229193006238 probable transmembrane helix predicted by TMHMM2.0 229193006239 probable transmembrane helix predicted by TMHMM2.0 229193006240 probable transmembrane helix predicted by TMHMM2.0 229193006241 probable transmembrane helix predicted by TMHMM2.0 229193006242 probable transmembrane helix predicted by TMHMM2.0 229193006243 probable transmembrane helix predicted by TMHMM2.0 229193006244 probable transmembrane helix predicted by TMHMM2.0 229193006245 probable transmembrane helix predicted by TMHMM2.0 229193006246 S-formylglutathione hydrolase; Region: PLN02442 229193006247 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 229193006248 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 229193006249 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 229193006250 substrate binding site [chemical binding]; other site 229193006251 catalytic Zn binding site [ion binding]; other site 229193006252 NAD binding site [chemical binding]; other site 229193006253 structural Zn binding site [ion binding]; other site 229193006254 dimer interface [polypeptide binding]; other site 229193006255 probable transmembrane helix predicted by TMHMM2.0 229193006256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193006257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193006258 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 229193006259 putative dimerization interface [polypeptide binding]; other site 229193006260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193006261 putative substrate translocation pore; other site 229193006262 probable transmembrane helix predicted by TMHMM2.0 229193006263 probable transmembrane helix predicted by TMHMM2.0 229193006264 probable transmembrane helix predicted by TMHMM2.0 229193006265 probable transmembrane helix predicted by TMHMM2.0 229193006266 probable transmembrane helix predicted by TMHMM2.0 229193006267 probable transmembrane helix predicted by TMHMM2.0 229193006268 probable transmembrane helix predicted by TMHMM2.0 229193006269 probable transmembrane helix predicted by TMHMM2.0 229193006270 probable transmembrane helix predicted by TMHMM2.0 229193006271 probable transmembrane helix predicted by TMHMM2.0 229193006272 probable transmembrane helix predicted by TMHMM2.0 229193006273 probable transmembrane helix predicted by TMHMM2.0 229193006274 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 229193006275 GTP cyclohydrolase I; Provisional; Region: PLN03044 229193006276 active site 229193006277 Predicted membrane protein [Function unknown]; Region: COG2311 229193006278 hypothetical protein; Provisional; Region: PRK10835 229193006279 HMMPfam match to entry PF04171 DUF405, E-value 7.9e-44 229193006280 probable transmembrane helix predicted by TMHMM2.0 229193006281 probable transmembrane helix predicted by TMHMM2.0 229193006282 probable transmembrane helix predicted by TMHMM2.0 229193006283 probable transmembrane helix predicted by TMHMM2.0 229193006284 probable transmembrane helix predicted by TMHMM2.0 229193006285 probable transmembrane helix predicted by TMHMM2.0 229193006286 HMMPfam match to entry PF04235 DUF418, E-value 6.7e-48 229193006287 probable transmembrane helix predicted by TMHMM2.0 229193006288 probable transmembrane helix predicted by TMHMM2.0 229193006289 probable transmembrane helix predicted by TMHMM2.0 229193006290 probable transmembrane helix predicted by TMHMM2.0 229193006291 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 229193006292 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 229193006293 ligand binding site [chemical binding]; other site 229193006294 calcium binding site [ion binding]; other site 229193006295 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193006296 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 229193006297 Walker A/P-loop; other site 229193006298 ATP binding site [chemical binding]; other site 229193006299 Q-loop/lid; other site 229193006300 ABC transporter signature motif; other site 229193006301 Walker B; other site 229193006302 D-loop; other site 229193006303 H-loop/switch region; other site 229193006304 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193006305 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193006306 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193006307 TM-ABC transporter signature motif; other site 229193006308 probable transmembrane helix predicted by TMHMM2.0 229193006309 probable transmembrane helix predicted by TMHMM2.0 229193006310 probable transmembrane helix predicted by TMHMM2.0 229193006311 probable transmembrane helix predicted by TMHMM2.0 229193006312 probable transmembrane helix predicted by TMHMM2.0 229193006313 probable transmembrane helix predicted by TMHMM2.0 229193006314 probable transmembrane helix predicted by TMHMM2.0 229193006315 probable transmembrane helix predicted by TMHMM2.0 229193006316 probable transmembrane helix predicted by TMHMM2.0 229193006317 probable transmembrane helix predicted by TMHMM2.0 229193006318 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 229193006319 putative active site [active] 229193006320 probable transmembrane helix predicted by TMHMM2.0 229193006321 malate dehydrogenase; Provisional; Region: PRK13529 229193006322 Malic enzyme, N-terminal domain; Region: malic; pfam00390 229193006323 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 229193006324 NAD(P) binding site [chemical binding]; other site 229193006325 cytidine deaminase; Provisional; Region: PRK09027 229193006326 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 229193006327 active site 229193006328 catalytic motif [active] 229193006329 Zn binding site [ion binding]; other site 229193006330 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 229193006331 active site 229193006332 catalytic motif [active] 229193006333 Zn binding site [ion binding]; other site 229193006334 hypothetical protein; Provisional; Region: PRK10711 229193006335 HMMPfam match to entry PF04172 LrgB, E-value 5e-118 229193006336 probable transmembrane helix predicted by TMHMM2.0 229193006337 probable transmembrane helix predicted by TMHMM2.0 229193006338 probable transmembrane helix predicted by TMHMM2.0 229193006339 probable transmembrane helix predicted by TMHMM2.0 229193006340 probable transmembrane helix predicted by TMHMM2.0 229193006341 hypothetical protein; Provisional; Region: PRK01821 229193006342 probable transmembrane helix predicted by TMHMM2.0 229193006343 probable transmembrane helix predicted by TMHMM2.0 229193006344 probable transmembrane helix predicted by TMHMM2.0 229193006345 probable transmembrane helix predicted by TMHMM2.0 229193006346 putative transporter; Provisional; Region: PRK10054 229193006347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193006348 putative substrate translocation pore; other site 229193006349 probable transmembrane helix predicted by TMHMM2.0 229193006350 probable transmembrane helix predicted by TMHMM2.0 229193006351 probable transmembrane helix predicted by TMHMM2.0 229193006352 probable transmembrane helix predicted by TMHMM2.0 229193006353 probable transmembrane helix predicted by TMHMM2.0 229193006354 probable transmembrane helix predicted by TMHMM2.0 229193006355 probable transmembrane helix predicted by TMHMM2.0 229193006356 probable transmembrane helix predicted by TMHMM2.0 229193006357 probable transmembrane helix predicted by TMHMM2.0 229193006358 probable transmembrane helix predicted by TMHMM2.0 229193006359 probable transmembrane helix predicted by TMHMM2.0 229193006360 probable transmembrane helix predicted by TMHMM2.0 229193006361 Uncharacterized conserved protein [Function unknown]; Region: COG5276 229193006362 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 229193006363 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 229193006364 putative ligand binding site [chemical binding]; other site 229193006365 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193006366 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 229193006367 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 229193006368 active site 229193006369 HIGH motif; other site 229193006370 KMSKS motif; other site 229193006371 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 229193006372 tRNA binding surface [nucleotide binding]; other site 229193006373 anticodon binding site; other site 229193006374 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 229193006375 dimer interface [polypeptide binding]; other site 229193006376 putative tRNA-binding site [nucleotide binding]; other site 229193006377 ProfileScan match to entry PS50886 TRBD, E-value 25.738 229193006378 antiporter inner membrane protein; Provisional; Region: PRK11670 229193006379 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 229193006380 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 229193006381 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 229193006382 ATP-binding site [chemical binding]; other site 229193006383 Sugar specificity; other site 229193006384 Pyrimidine base specificity; other site 229193006385 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 229193006386 trimer interface [polypeptide binding]; other site 229193006387 active site 229193006388 putative assembly protein; Provisional; Region: PRK10833 229193006389 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 229193006390 HMMPfam match to entry PF05170 AsmA, E-value 1.8e-32 229193006391 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 229193006392 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 229193006393 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 229193006394 Transporter associated domain; Region: CorC_HlyC; smart01091 229193006395 probable transmembrane helix predicted by TMHMM2.0 229193006396 probable transmembrane helix predicted by TMHMM2.0 229193006397 probable transmembrane helix predicted by TMHMM2.0 229193006398 probable transmembrane helix predicted by TMHMM2.0 229193006399 probable transmembrane helix predicted by TMHMM2.0 229193006400 probable transmembrane helix predicted by TMHMM2.0 229193006401 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 229193006402 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 229193006403 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 229193006404 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 229193006405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193006406 catalytic residue [active] 229193006407 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 229193006408 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 229193006409 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 229193006410 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 229193006411 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 229193006412 IucA / IucC family; Region: IucA_IucC; pfam04183 229193006413 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 229193006414 HMMPfam match to entry PF04183 IucA_IucC, E-value 2.3e-155 229193006415 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 229193006416 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 229193006417 Walker A/P-loop; other site 229193006418 ATP binding site [chemical binding]; other site 229193006419 Q-loop/lid; other site 229193006420 ABC transporter signature motif; other site 229193006421 Walker B; other site 229193006422 D-loop; other site 229193006423 H-loop/switch region; other site 229193006424 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 229193006425 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 229193006426 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193006427 ABC-ATPase subunit interface; other site 229193006428 dimer interface [polypeptide binding]; other site 229193006429 putative PBP binding regions; other site 229193006430 probable transmembrane helix predicted by TMHMM2.0 229193006431 probable transmembrane helix predicted by TMHMM2.0 229193006432 probable transmembrane helix predicted by TMHMM2.0 229193006433 probable transmembrane helix predicted by TMHMM2.0 229193006434 probable transmembrane helix predicted by TMHMM2.0 229193006435 probable transmembrane helix predicted by TMHMM2.0 229193006436 probable transmembrane helix predicted by TMHMM2.0 229193006437 probable transmembrane helix predicted by TMHMM2.0 229193006438 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 229193006439 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193006440 ABC-ATPase subunit interface; other site 229193006441 dimer interface [polypeptide binding]; other site 229193006442 putative PBP binding regions; other site 229193006443 probable transmembrane helix predicted by TMHMM2.0 229193006444 probable transmembrane helix predicted by TMHMM2.0 229193006445 probable transmembrane helix predicted by TMHMM2.0 229193006446 probable transmembrane helix predicted by TMHMM2.0 229193006447 probable transmembrane helix predicted by TMHMM2.0 229193006448 probable transmembrane helix predicted by TMHMM2.0 229193006449 probable transmembrane helix predicted by TMHMM2.0 229193006450 probable transmembrane helix predicted by TMHMM2.0 229193006451 probable transmembrane helix predicted by TMHMM2.0 229193006452 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 229193006453 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 229193006454 siderophore binding site; other site 229193006455 probable transmembrane helix predicted by TMHMM2.0 229193006456 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 229193006457 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 229193006458 N-terminal plug; other site 229193006459 ligand-binding site [chemical binding]; other site 229193006460 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 229193006461 IucA / IucC family; Region: IucA_IucC; pfam04183 229193006462 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 229193006463 HMMPfam match to entry PF04183 IucA_IucC, E-value 1.2e-145 229193006464 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 229193006465 active site 229193006466 tetramer interface; other site 229193006467 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 229193006468 active site 229193006469 tetramer interface; other site 229193006470 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 229193006471 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 229193006472 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 229193006473 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 229193006474 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 229193006475 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 229193006476 metal binding site [ion binding]; metal-binding site 229193006477 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 229193006478 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 229193006479 substrate binding site [chemical binding]; other site 229193006480 glutamase interaction surface [polypeptide binding]; other site 229193006481 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 229193006482 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 229193006483 catalytic residues [active] 229193006484 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 229193006485 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 229193006486 putative active site [active] 229193006487 oxyanion strand; other site 229193006488 catalytic triad [active] 229193006489 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 229193006490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193006491 active site 229193006492 motif I; other site 229193006493 motif II; other site 229193006494 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 229193006495 putative active site pocket [active] 229193006496 4-fold oligomerization interface [polypeptide binding]; other site 229193006497 metal binding residues [ion binding]; metal-binding site 229193006498 3-fold/trimer interface [polypeptide binding]; other site 229193006499 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 229193006500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 229193006501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193006502 homodimer interface [polypeptide binding]; other site 229193006503 catalytic residue [active] 229193006504 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 229193006505 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 229193006506 NAD binding site [chemical binding]; other site 229193006507 dimerization interface [polypeptide binding]; other site 229193006508 product binding site; other site 229193006509 substrate binding site [chemical binding]; other site 229193006510 zinc binding site [ion binding]; other site 229193006511 catalytic residues [active] 229193006512 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 229193006513 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 229193006514 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 229193006515 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 229193006516 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 229193006517 putative NAD(P) binding site [chemical binding]; other site 229193006518 Yersinia protein of unknown function (DUF3831); Region: DUF3831; pfam12908 229193006519 probable transmembrane helix predicted by TMHMM2.0 229193006520 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193006521 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193006522 TM-ABC transporter signature motif; other site 229193006523 probable transmembrane helix predicted by TMHMM2.0 229193006524 probable transmembrane helix predicted by TMHMM2.0 229193006525 probable transmembrane helix predicted by TMHMM2.0 229193006526 probable transmembrane helix predicted by TMHMM2.0 229193006527 probable transmembrane helix predicted by TMHMM2.0 229193006528 probable transmembrane helix predicted by TMHMM2.0 229193006529 probable transmembrane helix predicted by TMHMM2.0 229193006530 probable transmembrane helix predicted by TMHMM2.0 229193006531 probable transmembrane helix predicted by TMHMM2.0 229193006532 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 229193006533 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 229193006534 putative active site [active] 229193006535 metal binding site [ion binding]; metal-binding site 229193006536 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 229193006537 probable transmembrane helix predicted by TMHMM2.0 229193006538 probable transmembrane helix predicted by TMHMM2.0 229193006539 probable transmembrane helix predicted by TMHMM2.0 229193006540 probable transmembrane helix predicted by TMHMM2.0 229193006541 probable transmembrane helix predicted by TMHMM2.0 229193006542 probable transmembrane helix predicted by TMHMM2.0 229193006543 probable transmembrane helix predicted by TMHMM2.0 229193006544 probable transmembrane helix predicted by TMHMM2.0 229193006545 probable transmembrane helix predicted by TMHMM2.0 229193006546 probable transmembrane helix predicted by TMHMM2.0 229193006547 probable transmembrane helix predicted by TMHMM2.0 229193006548 probable transmembrane helix predicted by TMHMM2.0 229193006549 exonuclease I; Provisional; Region: sbcB; PRK11779 229193006550 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 229193006551 active site 229193006552 catalytic site [active] 229193006553 substrate binding site [chemical binding]; other site 229193006554 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 229193006555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 229193006556 NAD(P) binding site [chemical binding]; other site 229193006557 active site 229193006558 hypothetical protein; Provisional; Region: PRK05423 229193006559 HMMPfam match to entry PF04363 DUF496, E-value 1.6e-64 229193006560 probable transmembrane helix predicted by TMHMM2.0 229193006561 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 229193006562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193006563 putative substrate translocation pore; other site 229193006564 probable transmembrane helix predicted by TMHMM2.0 229193006565 probable transmembrane helix predicted by TMHMM2.0 229193006566 probable transmembrane helix predicted by TMHMM2.0 229193006567 probable transmembrane helix predicted by TMHMM2.0 229193006568 probable transmembrane helix predicted by TMHMM2.0 229193006569 probable transmembrane helix predicted by TMHMM2.0 229193006570 probable transmembrane helix predicted by TMHMM2.0 229193006571 probable transmembrane helix predicted by TMHMM2.0 229193006572 probable transmembrane helix predicted by TMHMM2.0 229193006573 probable transmembrane helix predicted by TMHMM2.0 229193006574 probable transmembrane helix predicted by TMHMM2.0 229193006575 probable transmembrane helix predicted by TMHMM2.0 229193006576 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 229193006577 HMMPfam match to entry PF04134 DUF393, E-value 1.2e-38 229193006578 probable transmembrane helix predicted by TMHMM2.0 229193006579 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 229193006580 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 229193006581 NAD binding site [chemical binding]; other site 229193006582 homotetramer interface [polypeptide binding]; other site 229193006583 homodimer interface [polypeptide binding]; other site 229193006584 active site 229193006585 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 229193006586 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 229193006587 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 229193006588 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 229193006589 putative active site pocket [active] 229193006590 metal binding site [ion binding]; metal-binding site 229193006591 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 229193006592 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 229193006593 phosphate binding site [ion binding]; other site 229193006594 argininosuccinate synthase; Validated; Region: PRK05370 229193006595 MATE family multidrug exporter; Provisional; Region: PRK10189 229193006596 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 229193006597 probable transmembrane helix predicted by TMHMM2.0 229193006598 probable transmembrane helix predicted by TMHMM2.0 229193006599 probable transmembrane helix predicted by TMHMM2.0 229193006600 probable transmembrane helix predicted by TMHMM2.0 229193006601 probable transmembrane helix predicted by TMHMM2.0 229193006602 probable transmembrane helix predicted by TMHMM2.0 229193006603 probable transmembrane helix predicted by TMHMM2.0 229193006604 probable transmembrane helix predicted by TMHMM2.0 229193006605 probable transmembrane helix predicted by TMHMM2.0 229193006606 probable transmembrane helix predicted by TMHMM2.0 229193006607 probable transmembrane helix predicted by TMHMM2.0 229193006608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193006609 Major Facilitator Superfamily; Region: MFS_1; pfam07690 229193006610 putative substrate translocation pore; other site 229193006611 probable transmembrane helix predicted by TMHMM2.0 229193006612 probable transmembrane helix predicted by TMHMM2.0 229193006613 probable transmembrane helix predicted by TMHMM2.0 229193006614 probable transmembrane helix predicted by TMHMM2.0 229193006615 probable transmembrane helix predicted by TMHMM2.0 229193006616 probable transmembrane helix predicted by TMHMM2.0 229193006617 probable transmembrane helix predicted by TMHMM2.0 229193006618 probable transmembrane helix predicted by TMHMM2.0 229193006619 probable transmembrane helix predicted by TMHMM2.0 229193006620 probable transmembrane helix predicted by TMHMM2.0 229193006621 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 229193006622 active site 229193006623 catalytic site [active] 229193006624 Zn binding site [ion binding]; other site 229193006625 tetramer interface [polypeptide binding]; other site 229193006626 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 229193006627 probable transmembrane helix predicted by TMHMM2.0 229193006628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 229193006629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 229193006630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193006631 active site 229193006632 phosphorylation site [posttranslational modification] 229193006633 intermolecular recognition site; other site 229193006634 dimerization interface [polypeptide binding]; other site 229193006635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193006636 DNA binding residues [nucleotide binding] 229193006637 dimerization interface [polypeptide binding]; other site 229193006638 DctM-like transporters; Region: DctM; pfam06808 229193006639 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 229193006640 probable transmembrane helix predicted by TMHMM2.0 229193006641 probable transmembrane helix predicted by TMHMM2.0 229193006642 probable transmembrane helix predicted by TMHMM2.0 229193006643 probable transmembrane helix predicted by TMHMM2.0 229193006644 probable transmembrane helix predicted by TMHMM2.0 229193006645 probable transmembrane helix predicted by TMHMM2.0 229193006646 probable transmembrane helix predicted by TMHMM2.0 229193006647 probable transmembrane helix predicted by TMHMM2.0 229193006648 probable transmembrane helix predicted by TMHMM2.0 229193006649 probable transmembrane helix predicted by TMHMM2.0 229193006650 probable transmembrane helix predicted by TMHMM2.0 229193006651 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 229193006652 HMMPfam match to entry PF04290 DctQ, E-value 2.9e-18 229193006653 probable transmembrane helix predicted by TMHMM2.0 229193006654 probable transmembrane helix predicted by TMHMM2.0 229193006655 probable transmembrane helix predicted by TMHMM2.0 229193006656 probable transmembrane helix predicted by TMHMM2.0 229193006657 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 229193006658 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 229193006659 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 229193006660 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 229193006661 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 229193006662 Melibiase; Region: Melibiase; pfam02065 229193006663 galactoside permease; Reviewed; Region: lacY; PRK09528 229193006664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193006665 putative substrate translocation pore; other site 229193006666 probable transmembrane helix predicted by TMHMM2.0 229193006667 probable transmembrane helix predicted by TMHMM2.0 229193006668 probable transmembrane helix predicted by TMHMM2.0 229193006669 probable transmembrane helix predicted by TMHMM2.0 229193006670 probable transmembrane helix predicted by TMHMM2.0 229193006671 probable transmembrane helix predicted by TMHMM2.0 229193006672 probable transmembrane helix predicted by TMHMM2.0 229193006673 probable transmembrane helix predicted by TMHMM2.0 229193006674 probable transmembrane helix predicted by TMHMM2.0 229193006675 probable transmembrane helix predicted by TMHMM2.0 229193006676 probable transmembrane helix predicted by TMHMM2.0 229193006677 probable transmembrane helix predicted by TMHMM2.0 229193006678 Transcriptional regulators [Transcription]; Region: PurR; COG1609 229193006679 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193006680 DNA binding site [nucleotide binding] 229193006681 domain linker motif; other site 229193006682 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 229193006683 ligand binding site [chemical binding]; other site 229193006684 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 229193006685 BlastProDom match to entry PD039488 sp_P76346_YEEI_ECOLI, E-value 6e-84 229193006686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 229193006687 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 229193006688 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 229193006689 ATP binding site [chemical binding]; other site 229193006690 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 229193006691 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 229193006692 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 229193006693 Walker A/P-loop; other site 229193006694 ATP binding site [chemical binding]; other site 229193006695 Q-loop/lid; other site 229193006696 ABC transporter signature motif; other site 229193006697 Walker B; other site 229193006698 D-loop; other site 229193006699 H-loop/switch region; other site 229193006700 probable transmembrane helix predicted by TMHMM2.0 229193006701 probable transmembrane helix predicted by TMHMM2.0 229193006702 probable transmembrane helix predicted by TMHMM2.0 229193006703 probable transmembrane helix predicted by TMHMM2.0 229193006704 probable transmembrane helix predicted by TMHMM2.0 229193006705 probable transmembrane helix predicted by TMHMM2.0 229193006706 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 229193006707 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193006708 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 229193006709 YobH-like protein; Region: YobH; pfam13996 229193006710 probable transmembrane helix predicted by TMHMM2.0 229193006711 YebO-like protein; Region: YebO; pfam13974 229193006712 probable transmembrane helix predicted by TMHMM2.0 229193006713 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 229193006714 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 229193006715 aromatic amino acid transporter; Provisional; Region: PRK10238 229193006716 probable transmembrane helix predicted by TMHMM2.0 229193006717 probable transmembrane helix predicted by TMHMM2.0 229193006718 probable transmembrane helix predicted by TMHMM2.0 229193006719 probable transmembrane helix predicted by TMHMM2.0 229193006720 probable transmembrane helix predicted by TMHMM2.0 229193006721 probable transmembrane helix predicted by TMHMM2.0 229193006722 probable transmembrane helix predicted by TMHMM2.0 229193006723 probable transmembrane helix predicted by TMHMM2.0 229193006724 probable transmembrane helix predicted by TMHMM2.0 229193006725 probable transmembrane helix predicted by TMHMM2.0 229193006726 probable transmembrane helix predicted by TMHMM2.0 229193006727 probable transmembrane helix predicted by TMHMM2.0 229193006728 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 229193006729 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 229193006730 DNA-binding site [nucleotide binding]; DNA binding site 229193006731 RNA-binding motif; other site 229193006732 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 229193006733 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 229193006734 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 229193006735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193006736 S-adenosylmethionine binding site [chemical binding]; other site 229193006737 BlastProDom match to entry PD024019 sp_P36999_RRMA_ECOLI, E-value 8e-82 229193006738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 229193006739 PAS domain; Region: PAS_9; pfam13426 229193006740 putative active site [active] 229193006741 heme pocket [chemical binding]; other site 229193006742 PAS domain S-box; Region: sensory_box; TIGR00229 229193006743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 229193006744 putative active site [active] 229193006745 heme pocket [chemical binding]; other site 229193006746 PAS domain S-box; Region: sensory_box; TIGR00229 229193006747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 229193006748 putative active site [active] 229193006749 heme pocket [chemical binding]; other site 229193006750 PAS fold; Region: PAS; pfam00989 229193006751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 229193006752 putative active site [active] 229193006753 heme pocket [chemical binding]; other site 229193006754 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 229193006755 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 229193006756 metal binding site [ion binding]; metal-binding site 229193006757 active site 229193006758 I-site; other site 229193006759 transposase/IS protein; Provisional; Region: PRK09183 229193006760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193006761 Walker A motif; other site 229193006762 ATP binding site [chemical binding]; other site 229193006763 Walker B motif; other site 229193006764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193006765 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193006766 DNA-binding interface [nucleotide binding]; DNA binding site 229193006767 Integrase core domain; Region: rve; pfam00665 229193006768 TOBE domain; Region: TOBE_2; pfam08402 229193006769 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 229193006770 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 229193006771 Walker A/P-loop; other site 229193006772 ATP binding site [chemical binding]; other site 229193006773 Q-loop/lid; other site 229193006774 ABC transporter signature motif; other site 229193006775 Walker B; other site 229193006776 D-loop; other site 229193006777 H-loop/switch region; other site 229193006778 BlastProDom match to entry PD039360 sp_Q57585_Y121_METJA, E-value 1e-07 229193006779 BlastProDom match to entry PD039360 sp_O27709_O27709_METTH, E-value 2e-08 229193006780 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 229193006781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193006782 dimer interface [polypeptide binding]; other site 229193006783 conserved gate region; other site 229193006784 putative PBP binding loops; other site 229193006785 ABC-ATPase subunit interface; other site 229193006786 probable transmembrane helix predicted by TMHMM2.0 229193006787 probable transmembrane helix predicted by TMHMM2.0 229193006788 probable transmembrane helix predicted by TMHMM2.0 229193006789 probable transmembrane helix predicted by TMHMM2.0 229193006790 probable transmembrane helix predicted by TMHMM2.0 229193006791 probable transmembrane helix predicted by TMHMM2.0 229193006792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193006793 dimer interface [polypeptide binding]; other site 229193006794 conserved gate region; other site 229193006795 putative PBP binding loops; other site 229193006796 ABC-ATPase subunit interface; other site 229193006797 probable transmembrane helix predicted by TMHMM2.0 229193006798 probable transmembrane helix predicted by TMHMM2.0 229193006799 probable transmembrane helix predicted by TMHMM2.0 229193006800 probable transmembrane helix predicted by TMHMM2.0 229193006801 probable transmembrane helix predicted by TMHMM2.0 229193006802 probable transmembrane helix predicted by TMHMM2.0 229193006803 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 229193006804 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 229193006805 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 229193006806 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 229193006807 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 229193006808 N-acetylmannosamine kinase; Provisional; Region: PRK05082 229193006809 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 229193006810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 229193006811 DNA-binding site [nucleotide binding]; DNA binding site 229193006812 UTRA domain; Region: UTRA; pfam07702 229193006813 probable transmembrane helix predicted by TMHMM2.0 229193006814 Contains Transposase, mutator family (Interpro|IPR001207) 229193006815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 229193006816 Protein of unknown function (DUF497); Region: DUF497; pfam04365 229193006817 HMMPfam match to entry PF04365 DUF497, E-value 3.4e-27 229193006818 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 229193006819 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 229193006820 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 229193006821 probable transmembrane helix predicted by TMHMM2.0 229193006822 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 229193006823 Transposase; Region: HTH_Tnp_1; cl17663 229193006824 Homeodomain-like domain; Region: HTH_32; pfam13565 229193006825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 229193006826 Integrase core domain; Region: rve; pfam00665 229193006827 Integrase core domain; Region: rve_3; pfam13683 229193006828 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 229193006829 ProfileScan match to entry PS50316 HIS_RICH, E-value 10.173 229193006830 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 229193006831 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 229193006832 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 229193006833 probable transmembrane helix predicted by TMHMM2.0 229193006834 probable transmembrane helix predicted by TMHMM2.0 229193006835 probable transmembrane helix predicted by TMHMM2.0 229193006836 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 229193006837 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 229193006838 GIY-YIG motif/motif A; other site 229193006839 active site 229193006840 catalytic site [active] 229193006841 putative DNA binding site [nucleotide binding]; other site 229193006842 metal binding site [ion binding]; metal-binding site 229193006843 UvrB/uvrC motif; Region: UVR; pfam02151 229193006844 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 229193006845 Helix-hairpin-helix motif; Region: HHH; pfam00633 229193006846 BlastProDom match to entry PD041672 sp_P07028_UVRC_ECOLI, E-value 5e-25 229193006847 response regulator; Provisional; Region: PRK09483 229193006848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193006849 active site 229193006850 phosphorylation site [posttranslational modification] 229193006851 intermolecular recognition site; other site 229193006852 dimerization interface [polypeptide binding]; other site 229193006853 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193006854 DNA binding residues [nucleotide binding] 229193006855 dimerization interface [polypeptide binding]; other site 229193006856 hypothetical protein; Provisional; Region: PRK10613 229193006857 GlpM protein; Region: GlpM; pfam06942 229193006858 probable transmembrane helix predicted by TMHMM2.0 229193006859 probable transmembrane helix predicted by TMHMM2.0 229193006860 probable transmembrane helix predicted by TMHMM2.0 229193006861 probable transmembrane helix predicted by TMHMM2.0 229193006862 probable transmembrane helix predicted by TMHMM2.0 229193006863 probable transmembrane helix predicted by TMHMM2.0 229193006864 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 229193006865 probable transmembrane helix predicted by TMHMM2.0 229193006866 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 229193006867 probable transmembrane helix predicted by TMHMM2.0 229193006868 probable transmembrane helix predicted by TMHMM2.0 229193006869 probable transmembrane helix predicted by TMHMM2.0 229193006870 probable transmembrane helix predicted by TMHMM2.0 229193006871 probable transmembrane helix predicted by TMHMM2.0 229193006872 probable transmembrane helix predicted by TMHMM2.0 229193006873 probable transmembrane helix predicted by TMHMM2.0 229193006874 probable transmembrane helix predicted by TMHMM2.0 229193006875 probable transmembrane helix predicted by TMHMM2.0 229193006876 probable transmembrane helix predicted by TMHMM2.0 229193006877 probable transmembrane helix predicted by TMHMM2.0 229193006878 probable transmembrane helix predicted by TMHMM2.0 229193006879 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 229193006880 Kelch motif; Region: Kelch_1; pfam01344 229193006881 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 229193006882 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 229193006883 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 229193006884 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 229193006885 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 229193006886 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 229193006887 Imelysin; Region: Peptidase_M75; pfam09375 229193006888 HMMPfam match to entry PF04302 DUF451, E-value 1.6e-149 229193006889 Iron permease FTR1 family; Region: FTR1; cl00475 229193006890 probable transmembrane helix predicted by TMHMM2.0 229193006891 probable transmembrane helix predicted by TMHMM2.0 229193006892 probable transmembrane helix predicted by TMHMM2.0 229193006893 probable transmembrane helix predicted by TMHMM2.0 229193006894 probable transmembrane helix predicted by TMHMM2.0 229193006895 probable transmembrane helix predicted by TMHMM2.0 229193006896 probable transmembrane helix predicted by TMHMM2.0 229193006897 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 229193006898 Na binding site [ion binding]; other site 229193006899 probable transmembrane helix predicted by TMHMM2.0 229193006900 probable transmembrane helix predicted by TMHMM2.0 229193006901 probable transmembrane helix predicted by TMHMM2.0 229193006902 probable transmembrane helix predicted by TMHMM2.0 229193006903 probable transmembrane helix predicted by TMHMM2.0 229193006904 probable transmembrane helix predicted by TMHMM2.0 229193006905 probable transmembrane helix predicted by TMHMM2.0 229193006906 probable transmembrane helix predicted by TMHMM2.0 229193006907 probable transmembrane helix predicted by TMHMM2.0 229193006908 probable transmembrane helix predicted by TMHMM2.0 229193006909 probable transmembrane helix predicted by TMHMM2.0 229193006910 probable transmembrane helix predicted by TMHMM2.0 229193006911 probable transmembrane helix predicted by TMHMM2.0 229193006912 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 229193006913 Predicted transcriptional regulator [Transcription]; Region: COG3905 229193006914 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 229193006915 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 229193006916 Glutamate binding site [chemical binding]; other site 229193006917 NAD binding site [chemical binding]; other site 229193006918 catalytic residues [active] 229193006919 Predicted transcriptional regulator [Transcription]; Region: COG4190 229193006920 MarR family; Region: MarR_2; cl17246 229193006921 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 229193006922 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 229193006923 Walker A/P-loop; other site 229193006924 ATP binding site [chemical binding]; other site 229193006925 Q-loop/lid; other site 229193006926 ABC transporter signature motif; other site 229193006927 Walker B; other site 229193006928 D-loop; other site 229193006929 H-loop/switch region; other site 229193006930 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 229193006931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193006932 dimer interface [polypeptide binding]; other site 229193006933 conserved gate region; other site 229193006934 putative PBP binding loops; other site 229193006935 ABC-ATPase subunit interface; other site 229193006936 probable transmembrane helix predicted by TMHMM2.0 229193006937 probable transmembrane helix predicted by TMHMM2.0 229193006938 probable transmembrane helix predicted by TMHMM2.0 229193006939 cystine transporter subunit; Provisional; Region: PRK11260 229193006940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193006941 substrate binding pocket [chemical binding]; other site 229193006942 membrane-bound complex binding site; other site 229193006943 hinge residues; other site 229193006944 D-cysteine desulfhydrase; Validated; Region: PRK03910 229193006945 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 229193006946 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193006947 catalytic residue [active] 229193006948 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 229193006949 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 229193006950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 229193006951 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 229193006952 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 229193006953 DNA binding residues [nucleotide binding] 229193006954 HMMPfam match to entry PF04545 sigma70_r4, E-value 2.7e-18 229193006955 HMMPfam match to entry PF04545 sigma70_r4, E-value 1.3e-12 229193006956 HMMPfam match to entry PF04539 sigma70_r3, E-value 3.3e-11 229193006957 HMMPfam match to entry PF04539 sigma70_r3, E-value 0.0099 229193006958 HMMPfam match to entry PF04542 sigma70_r2, E-value 7.2e-12 229193006959 HMMPfam match to entry PF04542 sigma70_r2, E-value 1.5e-15 229193006960 flagellin; Validated; Region: PRK06819 229193006961 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 229193006962 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 229193006963 flagellar capping protein; Reviewed; Region: fliD; PRK08032 229193006964 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 229193006965 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 229193006966 flagellar protein FliS; Validated; Region: fliS; PRK05685 229193006967 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 229193006968 probable transmembrane helix predicted by TMHMM2.0 229193006969 probable transmembrane helix predicted by TMHMM2.0 229193006970 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 229193006971 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193006972 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 229193006973 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 229193006974 minor groove reading motif; other site 229193006975 helix-hairpin-helix signature motif; other site 229193006976 active site 229193006977 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 229193006978 HMMPfam match to entry PF05012 DOC, E-value 2.1e-09 229193006979 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 229193006980 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 229193006981 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 229193006982 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 229193006983 probable transmembrane helix predicted by TMHMM2.0 229193006984 ProfileScan match to entry PS50310 ALA_RICH, E-value 9.179 229193006985 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 229193006986 FliG C-terminal domain; Region: FliG_C; pfam01706 229193006987 flagellar assembly protein H; Validated; Region: fliH; PRK05687 229193006988 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 229193006989 Flagellar assembly protein FliH; Region: FliH; pfam02108 229193006990 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 229193006991 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 229193006992 Walker A motif/ATP binding site; other site 229193006993 Walker B motif; other site 229193006994 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 229193006995 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 229193006996 ProfileScan match to entry PS50322 GLN_RICH, E-value 9.267 229193006997 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 229193006998 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 229193006999 ProfileScan match to entry PS50322 GLN_RICH, E-value 10.166 229193007000 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 229193007001 probable transmembrane helix predicted by TMHMM2.0 229193007002 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 229193007003 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 229193007004 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 229193007005 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 229193007006 probable transmembrane helix predicted by TMHMM2.0 229193007007 HMMPfam match to entry PF04347 FliO, E-value 1.6e-33 229193007008 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 229193007009 probable transmembrane helix predicted by TMHMM2.0 229193007010 probable transmembrane helix predicted by TMHMM2.0 229193007011 probable transmembrane helix predicted by TMHMM2.0 229193007012 probable transmembrane helix predicted by TMHMM2.0 229193007013 probable transmembrane helix predicted by TMHMM2.0 229193007014 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 229193007015 probable transmembrane helix predicted by TMHMM2.0 229193007016 probable transmembrane helix predicted by TMHMM2.0 229193007017 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 229193007018 probable transmembrane helix predicted by TMHMM2.0 229193007019 probable transmembrane helix predicted by TMHMM2.0 229193007020 probable transmembrane helix predicted by TMHMM2.0 229193007021 probable transmembrane helix predicted by TMHMM2.0 229193007022 probable transmembrane helix predicted by TMHMM2.0 229193007023 probable transmembrane helix predicted by TMHMM2.0 229193007024 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 229193007025 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 229193007026 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 229193007027 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 229193007028 substrate binding site [chemical binding]; other site 229193007029 ATP binding site [chemical binding]; other site 229193007030 BlastProDom match to entry PD023180 sp_Q9I1L2_Q9I1L2_PSEAE, E-value 2e-07 229193007031 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193007032 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193007033 TM-ABC transporter signature motif; other site 229193007034 probable transmembrane helix predicted by TMHMM2.0 229193007035 probable transmembrane helix predicted by TMHMM2.0 229193007036 probable transmembrane helix predicted by TMHMM2.0 229193007037 probable transmembrane helix predicted by TMHMM2.0 229193007038 probable transmembrane helix predicted by TMHMM2.0 229193007039 probable transmembrane helix predicted by TMHMM2.0 229193007040 probable transmembrane helix predicted by TMHMM2.0 229193007041 probable transmembrane helix predicted by TMHMM2.0 229193007042 probable transmembrane helix predicted by TMHMM2.0 229193007043 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 229193007044 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193007045 Walker A/P-loop; other site 229193007046 ATP binding site [chemical binding]; other site 229193007047 Q-loop/lid; other site 229193007048 ABC transporter signature motif; other site 229193007049 Walker B; other site 229193007050 D-loop; other site 229193007051 H-loop/switch region; other site 229193007052 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193007053 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 229193007054 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 229193007055 ligand binding site [chemical binding]; other site 229193007056 probable transmembrane helix predicted by TMHMM2.0 229193007057 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193007058 TM-ABC transporter signature motif; other site 229193007059 probable transmembrane helix predicted by TMHMM2.0 229193007060 probable transmembrane helix predicted by TMHMM2.0 229193007061 probable transmembrane helix predicted by TMHMM2.0 229193007062 probable transmembrane helix predicted by TMHMM2.0 229193007063 probable transmembrane helix predicted by TMHMM2.0 229193007064 probable transmembrane helix predicted by TMHMM2.0 229193007065 probable transmembrane helix predicted by TMHMM2.0 229193007066 probable transmembrane helix predicted by TMHMM2.0 229193007067 probable transmembrane helix predicted by TMHMM2.0 229193007068 probable transmembrane helix predicted by TMHMM2.0 229193007069 short chain dehydrogenase; Validated; Region: PRK08324 229193007070 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 229193007071 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 229193007072 putative NAD(P) binding site [chemical binding]; other site 229193007073 active site 229193007074 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 229193007075 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 229193007076 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 229193007077 HMMPfam match to entry PF04198 Sugar-bind, E-value 2e-72 229193007078 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 229193007079 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 229193007080 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 229193007081 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 229193007082 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 229193007083 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 229193007084 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 229193007085 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 229193007086 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 229193007087 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 229193007088 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 229193007089 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 229193007090 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12643 229193007091 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 229193007092 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 229193007093 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 229193007094 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 229193007095 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 229193007096 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 229193007097 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 229193007098 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 229193007099 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 229193007100 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 229193007101 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 229193007102 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 229193007103 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 229193007104 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 229193007105 BlastProDom match to entry PD004851 sp_Q56893_FLGB_YEREN, E-value 7e-65 229193007106 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 229193007107 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 229193007108 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 229193007109 HMMPfam match to entry PF04316 FlgM, E-value 8.7e-34 229193007110 Flagellar biosynthesis/type III secretory pathway chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3418 229193007111 HMMPfam match to entry PF05130 FlgN, E-value 1.3e-25 229193007112 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193007113 Flagellar protein FlhE; Region: FlhE; pfam06366 229193007114 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 229193007115 FHIPEP family; Region: FHIPEP; pfam00771 229193007116 probable transmembrane helix predicted by TMHMM2.0 229193007117 probable transmembrane helix predicted by TMHMM2.0 229193007118 probable transmembrane helix predicted by TMHMM2.0 229193007119 probable transmembrane helix predicted by TMHMM2.0 229193007120 probable transmembrane helix predicted by TMHMM2.0 229193007121 probable transmembrane helix predicted by TMHMM2.0 229193007122 probable transmembrane helix predicted by TMHMM2.0 229193007123 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 229193007124 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 229193007125 probable transmembrane helix predicted by TMHMM2.0 229193007126 probable transmembrane helix predicted by TMHMM2.0 229193007127 probable transmembrane helix predicted by TMHMM2.0 229193007128 probable transmembrane helix predicted by TMHMM2.0 229193007129 probable transmembrane helix predicted by TMHMM2.0 229193007130 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 229193007131 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 229193007132 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 229193007133 probable transmembrane helix predicted by TMHMM2.0 229193007134 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 229193007135 probable transmembrane helix predicted by TMHMM2.0 229193007136 probable transmembrane helix predicted by TMHMM2.0 229193007137 probable transmembrane helix predicted by TMHMM2.0 229193007138 probable transmembrane helix predicted by TMHMM2.0 229193007139 probable transmembrane helix predicted by TMHMM2.0 229193007140 probable transmembrane helix predicted by TMHMM2.0 229193007141 probable transmembrane helix predicted by TMHMM2.0 229193007142 probable transmembrane helix predicted by TMHMM2.0 229193007143 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 229193007144 HMMPfam match to entry PF04234 CopC, E-value 1.1e-34 229193007145 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 229193007146 Ferritin-like domain; Region: Ferritin; pfam00210 229193007147 ferroxidase diiron center [ion binding]; other site 229193007148 probable transmembrane helix predicted by TMHMM2.0 229193007149 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 229193007150 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 229193007151 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 229193007152 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 229193007153 hypothetical protein; Provisional; Region: PRK13680 229193007154 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 229193007155 YebG protein; Region: YebG; pfam07130 229193007156 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 229193007157 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 229193007158 ATP binding site [chemical binding]; other site 229193007159 Mg++ binding site [ion binding]; other site 229193007160 motif III; other site 229193007161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193007162 nucleotide binding region [chemical binding]; other site 229193007163 ATP-binding site [chemical binding]; other site 229193007164 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 229193007165 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 229193007166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 229193007167 ATP-grasp domain; Region: ATP-grasp; pfam02222 229193007168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3140 229193007169 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 229193007170 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 229193007171 chorismate binding enzyme; Region: Chorismate_bind; cl10555 229193007172 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 229193007173 putative active site [active] 229193007174 putative CoA binding site [chemical binding]; other site 229193007175 nudix motif; other site 229193007176 metal binding site [ion binding]; metal-binding site 229193007177 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 229193007178 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 229193007179 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 229193007180 4-hydroxyphenylacetate 3-monooxygenase, reductase component; Region: HpaC; TIGR02296 229193007181 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 229193007182 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 229193007183 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 229193007184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193007185 putative substrate translocation pore; other site 229193007186 probable transmembrane helix predicted by TMHMM2.0 229193007187 probable transmembrane helix predicted by TMHMM2.0 229193007188 probable transmembrane helix predicted by TMHMM2.0 229193007189 probable transmembrane helix predicted by TMHMM2.0 229193007190 probable transmembrane helix predicted by TMHMM2.0 229193007191 probable transmembrane helix predicted by TMHMM2.0 229193007192 probable transmembrane helix predicted by TMHMM2.0 229193007193 probable transmembrane helix predicted by TMHMM2.0 229193007194 probable transmembrane helix predicted by TMHMM2.0 229193007195 probable transmembrane helix predicted by TMHMM2.0 229193007196 probable transmembrane helix predicted by TMHMM2.0 229193007197 probable transmembrane helix predicted by TMHMM2.0 229193007198 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 229193007199 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 229193007200 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 229193007201 trimer interface [polypeptide binding]; other site 229193007202 putative substrate binding pocket [chemical binding]; other site 229193007203 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 229193007204 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 229193007205 putative active site [active] 229193007206 putative metal binding site [ion binding]; other site 229193007207 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 229193007208 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 229193007209 NAD binding site [chemical binding]; other site 229193007210 catalytic residues [active] 229193007211 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 229193007212 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 229193007213 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 229193007214 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 229193007215 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 229193007216 Transporter associated domain; Region: CorC_HlyC; smart01091 229193007217 probable transmembrane helix predicted by TMHMM2.0 229193007218 probable transmembrane helix predicted by TMHMM2.0 229193007219 probable transmembrane helix predicted by TMHMM2.0 229193007220 probable transmembrane helix predicted by TMHMM2.0 229193007221 probable transmembrane helix predicted by TMHMM2.0 229193007222 probable transmembrane helix predicted by TMHMM2.0 229193007223 probable transmembrane helix predicted by TMHMM2.0 229193007224 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 229193007225 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 229193007226 active pocket/dimerization site; other site 229193007227 active site 229193007228 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 229193007229 active site 229193007230 phosphorylation site [posttranslational modification] 229193007231 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 229193007232 probable transmembrane helix predicted by TMHMM2.0 229193007233 probable transmembrane helix predicted by TMHMM2.0 229193007234 probable transmembrane helix predicted by TMHMM2.0 229193007235 probable transmembrane helix predicted by TMHMM2.0 229193007236 probable transmembrane helix predicted by TMHMM2.0 229193007237 probable transmembrane helix predicted by TMHMM2.0 229193007238 probable transmembrane helix predicted by TMHMM2.0 229193007239 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 229193007240 probable transmembrane helix predicted by TMHMM2.0 229193007241 probable transmembrane helix predicted by TMHMM2.0 229193007242 hypothetical protein; Provisional; Region: PRK02913 229193007243 probable transmembrane helix predicted by TMHMM2.0 229193007244 probable transmembrane helix predicted by TMHMM2.0 229193007245 probable transmembrane helix predicted by TMHMM2.0 229193007246 hypothetical protein; Provisional; Region: PRK11469 229193007247 Domain of unknown function DUF; Region: DUF204; pfam02659 229193007248 Domain of unknown function DUF; Region: DUF204; pfam02659 229193007249 probable transmembrane helix predicted by TMHMM2.0 229193007250 probable transmembrane helix predicted by TMHMM2.0 229193007251 probable transmembrane helix predicted by TMHMM2.0 229193007252 probable transmembrane helix predicted by TMHMM2.0 229193007253 probable transmembrane helix predicted by TMHMM2.0 229193007254 probable transmembrane helix predicted by TMHMM2.0 229193007255 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193007256 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193007257 DNA-binding interface [nucleotide binding]; DNA binding site 229193007258 Integrase core domain; Region: rve; pfam00665 229193007259 transposase/IS protein; Provisional; Region: PRK09183 229193007260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193007261 Walker A motif; other site 229193007262 ATP binding site [chemical binding]; other site 229193007263 Walker B motif; other site 229193007264 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 229193007265 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 229193007266 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 229193007267 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 229193007268 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 229193007269 N-terminal plug; other site 229193007270 ligand-binding site [chemical binding]; other site 229193007271 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 229193007272 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 229193007273 acyl-activating enzyme (AAE) consensus motif; other site 229193007274 active site 229193007275 AMP binding site [chemical binding]; other site 229193007276 substrate binding site [chemical binding]; other site 229193007277 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 229193007278 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 229193007279 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 229193007280 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 229193007281 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 229193007282 active site 229193007283 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 229193007284 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 229193007285 Methyltransferase domain; Region: Methyltransf_12; pfam08242 229193007286 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 229193007287 KR domain; Region: KR; pfam08659 229193007288 NADP binding site [chemical binding]; other site 229193007289 active site 229193007290 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 229193007291 Condensation domain; Region: Condensation; pfam00668 229193007292 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 229193007293 Nonribosomal peptide synthase; Region: NRPS; pfam08415 229193007294 Methyltransferase domain; Region: Methyltransf_12; pfam08242 229193007295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 229193007296 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 229193007297 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 229193007298 Condensation domain; Region: Condensation; pfam00668 229193007299 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 229193007300 Nonribosomal peptide synthase; Region: NRPS; pfam08415 229193007301 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 229193007302 acyl-activating enzyme (AAE) consensus motif; other site 229193007303 AMP binding site [chemical binding]; other site 229193007304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193007305 S-adenosylmethionine binding site [chemical binding]; other site 229193007306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 229193007307 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 229193007308 Condensation domain; Region: Condensation; pfam00668 229193007309 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 229193007310 Nonribosomal peptide synthase; Region: NRPS; pfam08415 229193007311 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 229193007312 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 229193007313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193007314 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 229193007315 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 229193007316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193007317 Walker A/P-loop; other site 229193007318 ATP binding site [chemical binding]; other site 229193007319 Q-loop/lid; other site 229193007320 ABC transporter signature motif; other site 229193007321 Walker B; other site 229193007322 D-loop; other site 229193007323 H-loop/switch region; other site 229193007324 probable transmembrane helix predicted by TMHMM2.0 229193007325 probable transmembrane helix predicted by TMHMM2.0 229193007326 probable transmembrane helix predicted by TMHMM2.0 229193007327 probable transmembrane helix predicted by TMHMM2.0 229193007328 probable transmembrane helix predicted by TMHMM2.0 229193007329 probable transmembrane helix predicted by TMHMM2.0 229193007330 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 229193007331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193007332 Walker A/P-loop; other site 229193007333 ATP binding site [chemical binding]; other site 229193007334 Q-loop/lid; other site 229193007335 ABC transporter signature motif; other site 229193007336 Walker B; other site 229193007337 D-loop; other site 229193007338 H-loop/switch region; other site 229193007339 probable transmembrane helix predicted by TMHMM2.0 229193007340 probable transmembrane helix predicted by TMHMM2.0 229193007341 probable transmembrane helix predicted by TMHMM2.0 229193007342 probable transmembrane helix predicted by TMHMM2.0 229193007343 probable transmembrane helix predicted by TMHMM2.0 229193007344 muropeptide transporter; Validated; Region: ampG; cl17669 229193007345 probable transmembrane helix predicted by TMHMM2.0 229193007346 probable transmembrane helix predicted by TMHMM2.0 229193007347 probable transmembrane helix predicted by TMHMM2.0 229193007348 probable transmembrane helix predicted by TMHMM2.0 229193007349 probable transmembrane helix predicted by TMHMM2.0 229193007350 probable transmembrane helix predicted by TMHMM2.0 229193007351 probable transmembrane helix predicted by TMHMM2.0 229193007352 probable transmembrane helix predicted by TMHMM2.0 229193007353 probable transmembrane helix predicted by TMHMM2.0 229193007354 probable transmembrane helix predicted by TMHMM2.0 229193007355 probable transmembrane helix predicted by TMHMM2.0 229193007356 probable transmembrane helix predicted by TMHMM2.0 229193007357 salicylate synthase Irp9; Reviewed; Region: PRK06772 229193007358 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 229193007359 integrase; Provisional; Region: PRK09692 229193007360 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 229193007361 active site 229193007362 Int/Topo IB signature motif; other site 229193007363 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 229193007364 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193007365 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 229193007366 probable transmembrane helix predicted by TMHMM2.0 229193007367 Fimbrial protein; Region: Fimbrial; cl01416 229193007368 probable transmembrane helix predicted by TMHMM2.0 229193007369 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 229193007370 PapC N-terminal domain; Region: PapC_N; pfam13954 229193007371 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 229193007372 PapC C-terminal domain; Region: PapC_C; pfam13953 229193007373 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 229193007374 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193007375 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 229193007376 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 229193007377 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 229193007378 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193007379 substrate binding pocket [chemical binding]; other site 229193007380 membrane-bound complex binding site; other site 229193007381 hinge residues; other site 229193007382 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193007383 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 229193007384 substrate binding pocket [chemical binding]; other site 229193007385 membrane-bound complex binding site; other site 229193007386 hinge residues; other site 229193007387 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 229193007388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193007389 dimer interface [polypeptide binding]; other site 229193007390 phosphorylation site [posttranslational modification] 229193007391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193007392 ATP binding site [chemical binding]; other site 229193007393 Mg2+ binding site [ion binding]; other site 229193007394 G-X-G motif; other site 229193007395 Response regulator receiver domain; Region: Response_reg; pfam00072 229193007396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193007397 active site 229193007398 phosphorylation site [posttranslational modification] 229193007399 intermolecular recognition site; other site 229193007400 dimerization interface [polypeptide binding]; other site 229193007401 probable transmembrane helix predicted by TMHMM2.0 229193007402 transcriptional regulator FimZ; Provisional; Region: PRK09935 229193007403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193007404 active site 229193007405 phosphorylation site [posttranslational modification] 229193007406 intermolecular recognition site; other site 229193007407 dimerization interface [polypeptide binding]; other site 229193007408 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193007409 DNA binding residues [nucleotide binding] 229193007410 dimerization interface [polypeptide binding]; other site 229193007411 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 229193007412 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 229193007413 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 229193007414 BlastProDom match to entry PD005956 sp_Q9ZC36_Q9ZC36_YERPE, E-value 7e-85 229193007415 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 229193007416 putative active site [active] 229193007417 putative catalytic site [active] 229193007418 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 229193007419 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 229193007420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193007421 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 229193007422 putative dimerization interface [polypeptide binding]; other site 229193007423 putative substrate binding pocket [chemical binding]; other site 229193007424 probable transmembrane helix predicted by TMHMM2.0 229193007425 benzoate transport; Region: 2A0115; TIGR00895 229193007426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193007427 putative substrate translocation pore; other site 229193007428 probable transmembrane helix predicted by TMHMM2.0 229193007429 probable transmembrane helix predicted by TMHMM2.0 229193007430 probable transmembrane helix predicted by TMHMM2.0 229193007431 probable transmembrane helix predicted by TMHMM2.0 229193007432 probable transmembrane helix predicted by TMHMM2.0 229193007433 probable transmembrane helix predicted by TMHMM2.0 229193007434 probable transmembrane helix predicted by TMHMM2.0 229193007435 probable transmembrane helix predicted by TMHMM2.0 229193007436 probable transmembrane helix predicted by TMHMM2.0 229193007437 probable transmembrane helix predicted by TMHMM2.0 229193007438 probable transmembrane helix predicted by TMHMM2.0 229193007439 probable transmembrane helix predicted by TMHMM2.0 229193007440 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 229193007441 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 229193007442 active site 229193007443 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193007444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193007445 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 229193007446 dimerization interface [polypeptide binding]; other site 229193007447 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK12456 229193007448 probable transmembrane helix predicted by TMHMM2.0 229193007449 probable transmembrane helix predicted by TMHMM2.0 229193007450 probable transmembrane helix predicted by TMHMM2.0 229193007451 probable transmembrane helix predicted by TMHMM2.0 229193007452 probable transmembrane helix predicted by TMHMM2.0 229193007453 probable transmembrane helix predicted by TMHMM2.0 229193007454 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 229193007455 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 229193007456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193007457 homodimer interface [polypeptide binding]; other site 229193007458 catalytic residue [active] 229193007459 L-asparagine permease; Provisional; Region: PRK15049 229193007460 probable transmembrane helix predicted by TMHMM2.0 229193007461 probable transmembrane helix predicted by TMHMM2.0 229193007462 probable transmembrane helix predicted by TMHMM2.0 229193007463 probable transmembrane helix predicted by TMHMM2.0 229193007464 probable transmembrane helix predicted by TMHMM2.0 229193007465 probable transmembrane helix predicted by TMHMM2.0 229193007466 probable transmembrane helix predicted by TMHMM2.0 229193007467 probable transmembrane helix predicted by TMHMM2.0 229193007468 probable transmembrane helix predicted by TMHMM2.0 229193007469 probable transmembrane helix predicted by TMHMM2.0 229193007470 probable transmembrane helix predicted by TMHMM2.0 229193007471 probable transmembrane helix predicted by TMHMM2.0 229193007472 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 229193007473 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 229193007474 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 229193007475 hypothetical protein; Provisional; Region: PRK09989 229193007476 glutaminase; Reviewed; Region: PRK12356 229193007477 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 229193007478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193007479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193007480 probable transmembrane helix predicted by TMHMM2.0 229193007481 probable transmembrane helix predicted by TMHMM2.0 229193007482 probable transmembrane helix predicted by TMHMM2.0 229193007483 probable transmembrane helix predicted by TMHMM2.0 229193007484 probable transmembrane helix predicted by TMHMM2.0 229193007485 probable transmembrane helix predicted by TMHMM2.0 229193007486 probable transmembrane helix predicted by TMHMM2.0 229193007487 probable transmembrane helix predicted by TMHMM2.0 229193007488 probable transmembrane helix predicted by TMHMM2.0 229193007489 probable transmembrane helix predicted by TMHMM2.0 229193007490 probable transmembrane helix predicted by TMHMM2.0 229193007491 probable transmembrane helix predicted by TMHMM2.0 229193007492 probable transmembrane helix predicted by TMHMM2.0 229193007493 probable transmembrane helix predicted by TMHMM2.0 229193007494 probable transmembrane helix predicted by TMHMM2.0 229193007495 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 229193007496 probable transmembrane helix predicted by TMHMM2.0 229193007497 probable transmembrane helix predicted by TMHMM2.0 229193007498 probable transmembrane helix predicted by TMHMM2.0 229193007499 probable transmembrane helix predicted by TMHMM2.0 229193007500 probable transmembrane helix predicted by TMHMM2.0 229193007501 probable transmembrane helix predicted by TMHMM2.0 229193007502 probable transmembrane helix predicted by TMHMM2.0 229193007503 probable transmembrane helix predicted by TMHMM2.0 229193007504 probable transmembrane helix predicted by TMHMM2.0 229193007505 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 229193007506 probable transmembrane helix predicted by TMHMM2.0 229193007507 Predicted membrane protein [Function unknown]; Region: COG4393 229193007508 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 229193007509 Uncharacterized conserved protein [Function unknown]; Region: COG3350 229193007510 probable transmembrane helix predicted by TMHMM2.0 229193007511 probable transmembrane helix predicted by TMHMM2.0 229193007512 probable transmembrane helix predicted by TMHMM2.0 229193007513 ProfileScan match to entry PS50319 LEU_RICH, E-value 9.341 229193007514 probable transmembrane helix predicted by TMHMM2.0 229193007515 probable transmembrane helix predicted by TMHMM2.0 229193007516 probable transmembrane helix predicted by TMHMM2.0 229193007517 probable transmembrane helix predicted by TMHMM2.0 229193007518 probable transmembrane helix predicted by TMHMM2.0 229193007519 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 229193007520 FtsX-like permease family; Region: FtsX; pfam02687 229193007521 probable transmembrane helix predicted by TMHMM2.0 229193007522 probable transmembrane helix predicted by TMHMM2.0 229193007523 probable transmembrane helix predicted by TMHMM2.0 229193007524 probable transmembrane helix predicted by TMHMM2.0 229193007525 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 229193007526 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 229193007527 FtsX-like permease family; Region: FtsX; pfam02687 229193007528 probable transmembrane helix predicted by TMHMM2.0 229193007529 probable transmembrane helix predicted by TMHMM2.0 229193007530 probable transmembrane helix predicted by TMHMM2.0 229193007531 probable transmembrane helix predicted by TMHMM2.0 229193007532 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 229193007533 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 229193007534 Walker A/P-loop; other site 229193007535 ATP binding site [chemical binding]; other site 229193007536 Q-loop/lid; other site 229193007537 ABC transporter signature motif; other site 229193007538 Walker B; other site 229193007539 D-loop; other site 229193007540 H-loop/switch region; other site 229193007541 BlastProDom match to entry PD039360 sp_Q57585_Y121_METJA, E-value 2e-10 229193007542 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 229193007543 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 229193007544 catalytic residues [active] 229193007545 Cytochrome c553 [Energy production and conversion]; Region: COG2863 229193007546 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 229193007547 tellurite resistance protein TehB; Provisional; Region: PRK12335 229193007548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193007549 S-adenosylmethionine binding site [chemical binding]; other site 229193007550 putative endopeptidase; Provisional; Region: PRK14576 229193007551 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 229193007552 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 229193007553 active site 229193007554 outer membrane protein; Provisional; Region: hmsH; PRK14574 229193007555 outer membrane N-deacetylase; Provisional; Region: hmsF; PRK14581 229193007556 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 229193007557 putative active site [active] 229193007558 putative metal binding site [ion binding]; other site 229193007559 probable transmembrane helix predicted by TMHMM2.0 229193007560 N-glycosyltransferase; Provisional; Region: hmsR; PRK14583 229193007561 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 229193007562 DXD motif; other site 229193007563 probable transmembrane helix predicted by TMHMM2.0 229193007564 probable transmembrane helix predicted by TMHMM2.0 229193007565 probable transmembrane helix predicted by TMHMM2.0 229193007566 probable transmembrane helix predicted by TMHMM2.0 229193007567 hemin storage system protein; Provisional; Region: hmsS; PRK14584 229193007568 probable transmembrane helix predicted by TMHMM2.0 229193007569 probable transmembrane helix predicted by TMHMM2.0 229193007570 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 229193007571 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 229193007572 probable transmembrane helix predicted by TMHMM2.0 229193007573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193007574 MULE transposase domain; Region: MULE; pfam10551 229193007575 hypothetical protein; Provisional; Region: PRK10536 229193007576 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 229193007577 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 229193007578 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 229193007579 probable transmembrane helix predicted by TMHMM2.0 229193007580 probable transmembrane helix predicted by TMHMM2.0 229193007581 probable transmembrane helix predicted by TMHMM2.0 229193007582 probable transmembrane helix predicted by TMHMM2.0 229193007583 probable transmembrane helix predicted by TMHMM2.0 229193007584 probable transmembrane helix predicted by TMHMM2.0 229193007585 probable transmembrane helix predicted by TMHMM2.0 229193007586 probable transmembrane helix predicted by TMHMM2.0 229193007587 probable transmembrane helix predicted by TMHMM2.0 229193007588 probable transmembrane helix predicted by TMHMM2.0 229193007589 probable transmembrane helix predicted by TMHMM2.0 229193007590 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 229193007591 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 229193007592 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 229193007593 dimerization interface [polypeptide binding]; other site 229193007594 Histidine kinase; Region: HisKA_3; pfam07730 229193007595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193007596 ATP binding site [chemical binding]; other site 229193007597 Mg2+ binding site [ion binding]; other site 229193007598 G-X-G motif; other site 229193007599 probable transmembrane helix predicted by TMHMM2.0 229193007600 probable transmembrane helix predicted by TMHMM2.0 229193007601 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 229193007602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 229193007603 DNA-binding site [nucleotide binding]; DNA binding site 229193007604 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 229193007605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193007606 homodimer interface [polypeptide binding]; other site 229193007607 catalytic residue [active] 229193007608 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 229193007609 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 229193007610 inhibitor-cofactor binding pocket; inhibition site 229193007611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193007612 catalytic residue [active] 229193007613 arginine succinyltransferase; Provisional; Region: PRK10456 229193007614 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 229193007615 succinylglutamic semialdehyde dehydrogenase; Region: arg_catab_astD; TIGR03240 229193007616 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 229193007617 NAD(P) binding site [chemical binding]; other site 229193007618 catalytic residues [active] 229193007619 succinylarginine dihydrolase; Provisional; Region: PRK13281 229193007620 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 229193007621 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 229193007622 putative active site [active] 229193007623 Zn binding site [ion binding]; other site 229193007624 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 229193007625 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 229193007626 trimer interface [polypeptide binding]; other site 229193007627 eyelet of channel; other site 229193007628 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 229193007629 HMMPfam match to entry PF05013 FGase, E-value 1.5e-114 229193007630 imidazolonepropionase; Validated; Region: PRK09356 229193007631 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 229193007632 active site 229193007633 transposase/IS protein; Provisional; Region: PRK09183 229193007634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193007635 Walker A motif; other site 229193007636 ATP binding site [chemical binding]; other site 229193007637 Walker B motif; other site 229193007638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193007639 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193007640 DNA-binding interface [nucleotide binding]; DNA binding site 229193007641 Integrase core domain; Region: rve; pfam00665 229193007642 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 229193007643 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 229193007644 Spore Coat Protein U domain; Region: SCPU; pfam05229 229193007645 Uncharacterized secreted protein [Function unknown]; Region: COG5430 229193007646 probable transmembrane helix predicted by TMHMM2.0 229193007647 probable transmembrane helix predicted by TMHMM2.0 229193007648 probable transmembrane helix predicted by TMHMM2.0 229193007649 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 229193007650 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 229193007651 PapC C-terminal domain; Region: PapC_C; pfam13953 229193007652 probable transmembrane helix predicted by TMHMM2.0 229193007653 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 229193007654 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193007655 Uncharacterized secreted protein [Function unknown]; Region: COG5430 229193007656 Uncharacterized secreted protein [Function unknown]; Region: COG5430 229193007657 probable transmembrane helix predicted by TMHMM2.0 229193007658 Uncharacterized secreted protein [Function unknown]; Region: COG5430 229193007659 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 229193007660 mce related protein; Region: MCE; pfam02470 229193007661 mce related protein; Region: MCE; pfam02470 229193007662 mce related protein; Region: MCE; pfam02470 229193007663 mce related protein; Region: MCE; pfam02470 229193007664 mce related protein; Region: MCE; pfam02470 229193007665 mce related protein; Region: MCE; pfam02470 229193007666 probable transmembrane helix predicted by TMHMM2.0 229193007667 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 229193007668 Paraquat-inducible protein A; Region: PqiA; pfam04403 229193007669 Paraquat-inducible protein A; Region: PqiA; pfam04403 229193007670 HMMPfam match to entry PF04403 PqiA, E-value 3.7e-99 229193007671 probable transmembrane helix predicted by TMHMM2.0 229193007672 probable transmembrane helix predicted by TMHMM2.0 229193007673 probable transmembrane helix predicted by TMHMM2.0 229193007674 probable transmembrane helix predicted by TMHMM2.0 229193007675 HMMPfam match to entry PF04403 PqiA, E-value 2e-68 229193007676 probable transmembrane helix predicted by TMHMM2.0 229193007677 probable transmembrane helix predicted by TMHMM2.0 229193007678 probable transmembrane helix predicted by TMHMM2.0 229193007679 probable transmembrane helix predicted by TMHMM2.0 229193007680 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 229193007681 GAF domain; Region: GAF_2; pfam13185 229193007682 ProP expression regulator; Provisional; Region: PRK04950 229193007683 ProQ/FINO family; Region: ProQ; pfam04352 229193007684 HMMPfam match to entry PF04352 ProQ, E-value 1e-90 229193007685 carboxy-terminal protease; Provisional; Region: PRK11186 229193007686 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 229193007687 protein binding site [polypeptide binding]; other site 229193007688 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 229193007689 Catalytic dyad [active] 229193007690 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 229193007691 probable transmembrane helix predicted by TMHMM2.0 229193007692 heat shock protein HtpX; Provisional; Region: PRK05457 229193007693 probable transmembrane helix predicted by TMHMM2.0 229193007694 probable transmembrane helix predicted by TMHMM2.0 229193007695 probable transmembrane helix predicted by TMHMM2.0 229193007696 probable transmembrane helix predicted by TMHMM2.0 229193007697 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 229193007698 probable transmembrane helix predicted by TMHMM2.0 229193007699 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 229193007700 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193007701 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 229193007702 probable transmembrane helix predicted by TMHMM2.0 229193007703 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 229193007704 PapC N-terminal domain; Region: PapC_N; pfam13954 229193007705 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 229193007706 PapC C-terminal domain; Region: PapC_C; pfam13953 229193007707 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 229193007708 probable transmembrane helix predicted by TMHMM2.0 229193007709 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 229193007710 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193007711 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 229193007712 probable transmembrane helix predicted by TMHMM2.0 229193007713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193007714 Major Facilitator Superfamily; Region: MFS_1; pfam07690 229193007715 putative substrate translocation pore; other site 229193007716 probable transmembrane helix predicted by TMHMM2.0 229193007717 probable transmembrane helix predicted by TMHMM2.0 229193007718 probable transmembrane helix predicted by TMHMM2.0 229193007719 probable transmembrane helix predicted by TMHMM2.0 229193007720 probable transmembrane helix predicted by TMHMM2.0 229193007721 probable transmembrane helix predicted by TMHMM2.0 229193007722 probable transmembrane helix predicted by TMHMM2.0 229193007723 probable transmembrane helix predicted by TMHMM2.0 229193007724 probable transmembrane helix predicted by TMHMM2.0 229193007725 probable transmembrane helix predicted by TMHMM2.0 229193007726 probable transmembrane helix predicted by TMHMM2.0 229193007727 probable transmembrane helix predicted by TMHMM2.0 229193007728 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 229193007729 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 229193007730 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 229193007731 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 229193007732 dimerization interface [polypeptide binding]; other site 229193007733 putative Zn2+ binding site [ion binding]; other site 229193007734 putative DNA binding site [nucleotide binding]; other site 229193007735 Bacterial transcriptional regulator; Region: IclR; pfam01614 229193007736 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 229193007737 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 229193007738 amidase catalytic site [active] 229193007739 Zn binding residues [ion binding]; other site 229193007740 substrate binding site [chemical binding]; other site 229193007741 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 229193007742 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 229193007743 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 229193007744 probable transmembrane helix predicted by TMHMM2.0 229193007745 probable transmembrane helix predicted by TMHMM2.0 229193007746 probable transmembrane helix predicted by TMHMM2.0 229193007747 probable transmembrane helix predicted by TMHMM2.0 229193007748 probable transmembrane helix predicted by TMHMM2.0 229193007749 probable transmembrane helix predicted by TMHMM2.0 229193007750 probable transmembrane helix predicted by TMHMM2.0 229193007751 probable transmembrane helix predicted by TMHMM2.0 229193007752 probable transmembrane helix predicted by TMHMM2.0 229193007753 inner membrane protein; Provisional; Region: PRK11648 229193007754 probable transmembrane helix predicted by TMHMM2.0 229193007755 HMMPfam match to entry PF04307 DUF457, E-value 6.6e-31 229193007756 probable transmembrane helix predicted by TMHMM2.0 229193007757 probable transmembrane helix predicted by TMHMM2.0 229193007758 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 229193007759 probable transmembrane helix predicted by TMHMM2.0 229193007760 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 229193007761 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 229193007762 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 229193007763 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193007764 Walker A/P-loop; other site 229193007765 ATP binding site [chemical binding]; other site 229193007766 Q-loop/lid; other site 229193007767 ABC transporter signature motif; other site 229193007768 Walker B; other site 229193007769 D-loop; other site 229193007770 H-loop/switch region; other site 229193007771 TOBE domain; Region: TOBE_2; pfam08402 229193007772 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 229193007773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193007774 dimer interface [polypeptide binding]; other site 229193007775 conserved gate region; other site 229193007776 putative PBP binding loops; other site 229193007777 ABC-ATPase subunit interface; other site 229193007778 probable transmembrane helix predicted by TMHMM2.0 229193007779 probable transmembrane helix predicted by TMHMM2.0 229193007780 probable transmembrane helix predicted by TMHMM2.0 229193007781 probable transmembrane helix predicted by TMHMM2.0 229193007782 probable transmembrane helix predicted by TMHMM2.0 229193007783 probable transmembrane helix predicted by TMHMM2.0 229193007784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193007785 dimer interface [polypeptide binding]; other site 229193007786 conserved gate region; other site 229193007787 putative PBP binding loops; other site 229193007788 ABC-ATPase subunit interface; other site 229193007789 probable transmembrane helix predicted by TMHMM2.0 229193007790 probable transmembrane helix predicted by TMHMM2.0 229193007791 probable transmembrane helix predicted by TMHMM2.0 229193007792 probable transmembrane helix predicted by TMHMM2.0 229193007793 probable transmembrane helix predicted by TMHMM2.0 229193007794 probable transmembrane helix predicted by TMHMM2.0 229193007795 probable transmembrane helix predicted by TMHMM2.0 229193007796 probable transmembrane helix predicted by TMHMM2.0 229193007797 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 229193007798 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 229193007799 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 229193007800 NADP binding site [chemical binding]; other site 229193007801 homodimer interface [polypeptide binding]; other site 229193007802 active site 229193007803 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 229193007804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193007805 MULE transposase domain; Region: MULE; pfam10551 229193007806 hypothetical protein; Provisional; Region: PRK11280 229193007807 probable transmembrane helix predicted by TMHMM2.0 229193007808 transcription-repair coupling factor; Provisional; Region: PRK10689 229193007809 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 229193007810 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 229193007811 ATP binding site [chemical binding]; other site 229193007812 putative Mg++ binding site [ion binding]; other site 229193007813 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193007814 nucleotide binding region [chemical binding]; other site 229193007815 ATP-binding site [chemical binding]; other site 229193007816 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 229193007817 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 229193007818 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 229193007819 FtsX-like permease family; Region: FtsX; pfam02687 229193007820 probable transmembrane helix predicted by TMHMM2.0 229193007821 probable transmembrane helix predicted by TMHMM2.0 229193007822 probable transmembrane helix predicted by TMHMM2.0 229193007823 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 229193007824 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 229193007825 Walker A/P-loop; other site 229193007826 ATP binding site [chemical binding]; other site 229193007827 Q-loop/lid; other site 229193007828 ABC transporter signature motif; other site 229193007829 Walker B; other site 229193007830 D-loop; other site 229193007831 H-loop/switch region; other site 229193007832 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 229193007833 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 229193007834 FtsX-like permease family; Region: FtsX; pfam02687 229193007835 probable transmembrane helix predicted by TMHMM2.0 229193007836 probable transmembrane helix predicted by TMHMM2.0 229193007837 probable transmembrane helix predicted by TMHMM2.0 229193007838 probable transmembrane helix predicted by TMHMM2.0 229193007839 fructokinase; Reviewed; Region: PRK09557 229193007840 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 229193007841 nucleotide binding site [chemical binding]; other site 229193007842 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 229193007843 NAD-dependent deacetylase; Provisional; Region: PRK00481 229193007844 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 229193007845 NAD+ binding site [chemical binding]; other site 229193007846 substrate binding site [chemical binding]; other site 229193007847 Zn binding site [ion binding]; other site 229193007848 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 229193007849 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 229193007850 metal binding site [ion binding]; metal-binding site 229193007851 dimer interface [polypeptide binding]; other site 229193007852 Uncharacterized conserved protein [Function unknown]; Region: COG2850 229193007853 Cupin-like domain; Region: Cupin_8; pfam13621 229193007854 sensor protein PhoQ; Provisional; Region: PRK10815 229193007855 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 229193007856 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 229193007857 dimer interface [polypeptide binding]; other site 229193007858 phosphorylation site [posttranslational modification] 229193007859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193007860 ATP binding site [chemical binding]; other site 229193007861 Mg2+ binding site [ion binding]; other site 229193007862 G-X-G motif; other site 229193007863 probable transmembrane helix predicted by TMHMM2.0 229193007864 probable transmembrane helix predicted by TMHMM2.0 229193007865 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 229193007866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193007867 active site 229193007868 phosphorylation site [posttranslational modification] 229193007869 intermolecular recognition site; other site 229193007870 dimerization interface [polypeptide binding]; other site 229193007871 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193007872 DNA binding site [nucleotide binding] 229193007873 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 229193007874 adenylosuccinate lyase; Provisional; Region: PRK09285 229193007875 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 229193007876 tetramer interface [polypeptide binding]; other site 229193007877 active site 229193007878 putative lysogenization regulator; Reviewed; Region: PRK00218 229193007879 HMMPfam match to entry PF04356 DUF489, E-value 1.3e-124 229193007880 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 229193007881 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 229193007882 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 229193007883 nudix motif; other site 229193007884 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 229193007885 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 229193007886 probable active site [active] 229193007887 isocitrate dehydrogenase; Validated; Region: PRK07362 229193007888 isocitrate dehydrogenase; Reviewed; Region: PRK07006 229193007889 Transcriptional regulators [Transcription]; Region: PurR; COG1609 229193007890 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193007891 DNA binding site [nucleotide binding] 229193007892 domain linker motif; other site 229193007893 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 229193007894 putative dimerization interface [polypeptide binding]; other site 229193007895 putative ligand binding site [chemical binding]; other site 229193007896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 229193007897 PAS domain; Region: PAS_9; pfam13426 229193007898 putative active site [active] 229193007899 heme pocket [chemical binding]; other site 229193007900 HAMP domain; Region: HAMP; pfam00672 229193007901 dimerization interface [polypeptide binding]; other site 229193007902 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 229193007903 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 229193007904 dimer interface [polypeptide binding]; other site 229193007905 putative CheW interface [polypeptide binding]; other site 229193007906 BlastProDom match to entry PD000571 sp_P02942_MCP1_ECOLI, E-value 7e-08 229193007907 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 229193007908 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 229193007909 NADP binding site [chemical binding]; other site 229193007910 Predicted transcriptional regulators [Transcription]; Region: COG1733 229193007911 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 229193007912 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 229193007913 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 229193007914 catalytic core [active] 229193007915 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 229193007916 BlastProDom match to entry PD025090 sp_P07102_PPA_ECOLI, E-value 2e-99 229193007917 YdfZ protein; Region: YdfZ; pfam14001 229193007918 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 229193007919 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 229193007920 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 229193007921 putative DNA binding site [nucleotide binding]; other site 229193007922 putative Zn2+ binding site [ion binding]; other site 229193007923 AsnC family; Region: AsnC_trans_reg; pfam01037 229193007924 ProfileScan match to entry PS50320 MET_RICH, E-value 9.850 229193007925 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 229193007926 probable transmembrane helix predicted by TMHMM2.0 229193007927 probable transmembrane helix predicted by TMHMM2.0 229193007928 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 229193007929 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 229193007930 NAD(P) binding site [chemical binding]; other site 229193007931 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 229193007932 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 229193007933 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 229193007934 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 229193007935 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 229193007936 ProfileScan match to entry PS50322 GLN_RICH, E-value 8.882 229193007937 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 229193007938 DNA-binding site [nucleotide binding]; DNA binding site 229193007939 RNA-binding motif; other site 229193007940 hypothetical protein; Provisional; Region: PRK10708 229193007941 Contains Ligand binding Tar (Interpro|IPR003122, (GO:0016020)) . Contains Ligand binding Tar (Interpro|IPR003122, (GO:0016020)). Contains Histidine kinase, HAMP region (Interpro|IPR003660, (GO:0016020)). Contains Bacterial chemotaxis sensory transducer (Interpro|IPR004089, (GO:0016020)). Contains Methyl-accepting chemotaxis protein 229193007942 magnesium transport protein MgtC; Provisional; Region: PRK15385 229193007943 MgtC family; Region: MgtC; pfam02308 229193007944 probable transmembrane helix predicted by TMHMM2.0 229193007945 probable transmembrane helix predicted by TMHMM2.0 229193007946 probable transmembrane helix predicted by TMHMM2.0 229193007947 probable transmembrane helix predicted by TMHMM2.0 229193007948 magnesium-transporting ATPase; Provisional; Region: PRK15122 229193007949 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 229193007950 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 229193007951 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 229193007952 Soluble P-type ATPase [General function prediction only]; Region: COG4087 229193007953 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 229193007954 probable transmembrane helix predicted by TMHMM2.0 229193007955 probable transmembrane helix predicted by TMHMM2.0 229193007956 probable transmembrane helix predicted by TMHMM2.0 229193007957 probable transmembrane helix predicted by TMHMM2.0 229193007958 probable transmembrane helix predicted by TMHMM2.0 229193007959 probable transmembrane helix predicted by TMHMM2.0 229193007960 probable transmembrane helix predicted by TMHMM2.0 229193007961 probable transmembrane helix predicted by TMHMM2.0 229193007962 transcriptional activator FlhC; Provisional; Region: PRK12722 229193007963 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 229193007964 flagellar motor protein MotA; Validated; Region: PRK09110 229193007965 probable transmembrane helix predicted by TMHMM2.0 229193007966 probable transmembrane helix predicted by TMHMM2.0 229193007967 probable transmembrane helix predicted by TMHMM2.0 229193007968 probable transmembrane helix predicted by TMHMM2.0 229193007969 flagellar motor protein MotB; Validated; Region: motB; PRK09041 229193007970 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 229193007971 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 229193007972 ligand binding site [chemical binding]; other site 229193007973 probable transmembrane helix predicted by TMHMM2.0 229193007974 chemotaxis protein CheA; Provisional; Region: PRK10547 229193007975 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 229193007976 putative binding surface; other site 229193007977 active site 229193007978 CheY binding; Region: CheY-binding; pfam09078 229193007979 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 229193007980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193007981 ATP binding site [chemical binding]; other site 229193007982 Mg2+ binding site [ion binding]; other site 229193007983 G-X-G motif; other site 229193007984 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 229193007985 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 229193007986 putative CheA interaction surface; other site 229193007987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193007988 putative substrate translocation pore; other site 229193007989 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 229193007990 probable transmembrane helix predicted by TMHMM2.0 229193007991 probable transmembrane helix predicted by TMHMM2.0 229193007992 probable transmembrane helix predicted by TMHMM2.0 229193007993 probable transmembrane helix predicted by TMHMM2.0 229193007994 probable transmembrane helix predicted by TMHMM2.0 229193007995 probable transmembrane helix predicted by TMHMM2.0 229193007996 probable transmembrane helix predicted by TMHMM2.0 229193007997 probable transmembrane helix predicted by TMHMM2.0 229193007998 probable transmembrane helix predicted by TMHMM2.0 229193007999 probable transmembrane helix predicted by TMHMM2.0 229193008000 probable transmembrane helix predicted by TMHMM2.0 229193008001 probable transmembrane helix predicted by TMHMM2.0 229193008002 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 229193008003 homotrimer interaction site [polypeptide binding]; other site 229193008004 putative active site [active] 229193008005 BlastProDom match to entry PD002429 sp_Q9X445_Q9X445_SALTY, E-value 2e-19 229193008006 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 229193008007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 229193008008 YheO-like PAS domain; Region: PAS_6; pfam08348 229193008009 HTH domain; Region: HTH_22; pfam13309 229193008010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193008011 MULE transposase domain; Region: MULE; pfam10551 229193008012 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 229193008013 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 229193008014 Autotransporter beta-domain; Region: Autotransporter; smart00869 229193008015 Predicted membrane protein [Function unknown]; Region: COG5373 229193008016 probable transmembrane helix predicted by TMHMM2.0 229193008017 probable transmembrane helix predicted by TMHMM2.0 229193008018 probable transmembrane helix predicted by TMHMM2.0 229193008019 probable transmembrane helix predicted by TMHMM2.0 229193008020 probable transmembrane helix predicted by TMHMM2.0 229193008021 ProfileScan match to entry PS50319 LEU_RICH, E-value 11.052 229193008022 probable transmembrane helix predicted by TMHMM2.0 229193008023 probable transmembrane helix predicted by TMHMM2.0 229193008024 probable transmembrane helix predicted by TMHMM2.0 229193008025 probable transmembrane helix predicted by TMHMM2.0 229193008026 probable transmembrane helix predicted by TMHMM2.0 229193008027 probable transmembrane helix predicted by TMHMM2.0 229193008028 probable transmembrane helix predicted by TMHMM2.0 229193008029 probable transmembrane helix predicted by TMHMM2.0 229193008030 probable transmembrane helix predicted by TMHMM2.0 229193008031 probable transmembrane helix predicted by TMHMM2.0 229193008032 probable transmembrane helix predicted by TMHMM2.0 229193008033 probable transmembrane helix predicted by TMHMM2.0 229193008034 probable transmembrane helix predicted by TMHMM2.0 229193008035 probable transmembrane helix predicted by TMHMM2.0 229193008036 probable transmembrane helix predicted by TMHMM2.0 229193008037 probable transmembrane helix predicted by TMHMM2.0 229193008038 probable transmembrane helix predicted by TMHMM2.0 229193008039 probable transmembrane helix predicted by TMHMM2.0 229193008040 probable transmembrane helix predicted by TMHMM2.0 229193008041 probable transmembrane helix predicted by TMHMM2.0 229193008042 hypothetical protein; Provisional; Region: PRK10215 229193008043 probable transmembrane helix predicted by TMHMM2.0 229193008044 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 229193008045 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 229193008046 dimer interface [polypeptide binding]; other site 229193008047 ligand binding site [chemical binding]; other site 229193008048 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 229193008049 dimerization interface [polypeptide binding]; other site 229193008050 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 229193008051 dimer interface [polypeptide binding]; other site 229193008052 putative CheW interface [polypeptide binding]; other site 229193008053 probable transmembrane helix predicted by TMHMM2.0 229193008054 probable transmembrane helix predicted by TMHMM2.0 229193008055 BlastProDom match to entry PD000571 sp_P07018_MCP4_ECOLI, E-value 1e-10 229193008056 methyl-accepting protein IV; Provisional; Region: PRK09793 229193008057 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 229193008058 dimer interface [polypeptide binding]; other site 229193008059 ligand binding site [chemical binding]; other site 229193008060 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 229193008061 dimerization interface [polypeptide binding]; other site 229193008062 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 229193008063 dimer interface [polypeptide binding]; other site 229193008064 putative CheW interface [polypeptide binding]; other site 229193008065 probable transmembrane helix predicted by TMHMM2.0 229193008066 probable transmembrane helix predicted by TMHMM2.0 229193008067 BlastProDom match to entry PD000571 sp_P21823_MCPD_ENTAE, E-value 1e-10 229193008068 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 229193008069 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 229193008070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193008071 BlastProDom match to entry PD003728 sp_P07364_CHER_ECOLI, E-value 2e-87 229193008072 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 229193008073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193008074 active site 229193008075 phosphorylation site [posttranslational modification] 229193008076 intermolecular recognition site; other site 229193008077 dimerization interface [polypeptide binding]; other site 229193008078 CheB methylesterase; Region: CheB_methylest; pfam01339 229193008079 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 229193008080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193008081 active site 229193008082 phosphorylation site [posttranslational modification] 229193008083 intermolecular recognition site; other site 229193008084 dimerization interface [polypeptide binding]; other site 229193008085 chemotaxis regulator CheZ; Provisional; Region: PRK11166 229193008086 HMMPfam match to entry PF04344 CheZ, E-value 2.5e-117 229193008087 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 229193008088 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 229193008089 amidase catalytic site [active] 229193008090 Zn binding residues [ion binding]; other site 229193008091 substrate binding site [chemical binding]; other site 229193008092 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 229193008093 probable transmembrane helix predicted by TMHMM2.0 229193008094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193008095 MULE transposase domain; Region: MULE; pfam10551 229193008096 Lipase; Region: Lipase; pfam00151 229193008097 Patatin-like phospholipase; Region: Patatin; pfam01734 229193008098 nucleophile elbow; other site 229193008099 probable transmembrane helix predicted by TMHMM2.0 229193008100 transposase/IS protein; Provisional; Region: PRK09183 229193008101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193008102 Walker A motif; other site 229193008103 ATP binding site [chemical binding]; other site 229193008104 Walker B motif; other site 229193008105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193008106 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193008107 DNA-binding interface [nucleotide binding]; DNA binding site 229193008108 Integrase core domain; Region: rve; pfam00665 229193008109 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 229193008110 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 229193008111 active site 229193008112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 229193008113 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 229193008114 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 229193008115 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 229193008116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 229193008117 NAD(P) binding site [chemical binding]; other site 229193008118 active site 229193008119 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 229193008120 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 229193008121 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 229193008122 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 229193008123 extended (e) SDRs; Region: SDR_e; cd08946 229193008124 NAD(P) binding site [chemical binding]; other site 229193008125 active site 229193008126 substrate binding site [chemical binding]; other site 229193008127 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 229193008128 active site 229193008129 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 229193008130 probable transmembrane helix predicted by TMHMM2.0 229193008131 probable transmembrane helix predicted by TMHMM2.0 229193008132 probable transmembrane helix predicted by TMHMM2.0 229193008133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193008134 MULE transposase domain; Region: MULE; pfam10551 229193008135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 229193008136 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 229193008137 Sel1-like repeats; Region: SEL1; smart00671 229193008138 Sel1-like repeats; Region: SEL1; smart00671 229193008139 Sel1-like repeats; Region: SEL1; smart00671 229193008140 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 229193008141 probable transmembrane helix predicted by TMHMM2.0 229193008142 probable transmembrane helix predicted by TMHMM2.0 229193008143 hypothetical protein; Provisional; Region: PRK09273 229193008144 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 229193008145 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 229193008146 Methyltransferase domain; Region: Methyltransf_12; pfam08242 229193008147 classical (c) SDRs; Region: SDR_c; cd05233 229193008148 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 229193008149 NAD(P) binding site [chemical binding]; other site 229193008150 active site 229193008151 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 229193008152 HEAT repeats; Region: HEAT_2; pfam13646 229193008153 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 229193008154 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 229193008155 catalytic site [active] 229193008156 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 229193008157 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 229193008158 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 229193008159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 229193008160 dimerization interface [polypeptide binding]; other site 229193008161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193008162 dimer interface [polypeptide binding]; other site 229193008163 phosphorylation site [posttranslational modification] 229193008164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193008165 ATP binding site [chemical binding]; other site 229193008166 Mg2+ binding site [ion binding]; other site 229193008167 G-X-G motif; other site 229193008168 probable transmembrane helix predicted by TMHMM2.0 229193008169 probable transmembrane helix predicted by TMHMM2.0 229193008170 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 229193008171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193008172 active site 229193008173 phosphorylation site [posttranslational modification] 229193008174 intermolecular recognition site; other site 229193008175 dimerization interface [polypeptide binding]; other site 229193008176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193008177 DNA binding site [nucleotide binding] 229193008178 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 229193008179 flavodoxin; Provisional; Region: PRK06934 229193008180 probable transmembrane helix predicted by TMHMM2.0 229193008181 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 229193008182 probable transmembrane helix predicted by TMHMM2.0 229193008183 probable transmembrane helix predicted by TMHMM2.0 229193008184 probable transmembrane helix predicted by TMHMM2.0 229193008185 probable transmembrane helix predicted by TMHMM2.0 229193008186 probable transmembrane helix predicted by TMHMM2.0 229193008187 ProfileScan match to entry PS50314 PHE_RICH, E-value 8.939 229193008188 probable transmembrane helix predicted by TMHMM2.0 229193008189 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 229193008190 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 229193008191 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 229193008192 active site residue [active] 229193008193 Integrase core domain; Region: rve; pfam00665 229193008194 Integrase core domain; Region: rve_3; pfam13683 229193008195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 229193008196 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193008197 GTP-binding protein YchF; Reviewed; Region: PRK09601 229193008198 YchF GTPase; Region: YchF; cd01900 229193008199 G1 box; other site 229193008200 GTP/Mg2+ binding site [chemical binding]; other site 229193008201 Switch I region; other site 229193008202 G2 box; other site 229193008203 Switch II region; other site 229193008204 G3 box; other site 229193008205 G4 box; other site 229193008206 G5 box; other site 229193008207 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 229193008208 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 229193008209 putative active site [active] 229193008210 catalytic residue [active] 229193008211 hypothetical protein; Provisional; Region: PRK10692 229193008212 probable transmembrane helix predicted by TMHMM2.0 229193008213 probable transmembrane helix predicted by TMHMM2.0 229193008214 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 229193008215 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 229193008216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 229193008217 active site 229193008218 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 229193008219 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 229193008220 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 229193008221 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 229193008222 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 229193008223 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 229193008224 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 229193008225 tRNA; other site 229193008226 putative tRNA binding site [nucleotide binding]; other site 229193008227 putative NADP binding site [chemical binding]; other site 229193008228 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 229193008229 HMMPfam match to entry PF05201 GlutR_N, E-value 1.2e-85 229193008230 HMMPfam match to entry PF05200 GlutR_NAD_bind, E-value 3.4e-86 229193008231 peptide chain release factor 1; Validated; Region: prfA; PRK00591 229193008232 This domain is found in peptide chain release factors; Region: PCRF; smart00937 229193008233 RF-1 domain; Region: RF-1; pfam00472 229193008234 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 229193008235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 229193008236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3094 229193008237 HMMPfam match to entry PF04247 SirB, E-value 8e-50 229193008238 probable transmembrane helix predicted by TMHMM2.0 229193008239 probable transmembrane helix predicted by TMHMM2.0 229193008240 probable transmembrane helix predicted by TMHMM2.0 229193008241 probable transmembrane helix predicted by TMHMM2.0 229193008242 hypothetical protein; Provisional; Region: PRK10941 229193008243 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 229193008244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 229193008245 binding surface 229193008246 TPR motif; other site 229193008247 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 229193008248 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 229193008249 putative transporter; Provisional; Region: PRK11660 229193008250 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 229193008251 Sulfate transporter family; Region: Sulfate_transp; pfam00916 229193008252 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 229193008253 probable transmembrane helix predicted by TMHMM2.0 229193008254 probable transmembrane helix predicted by TMHMM2.0 229193008255 probable transmembrane helix predicted by TMHMM2.0 229193008256 probable transmembrane helix predicted by TMHMM2.0 229193008257 probable transmembrane helix predicted by TMHMM2.0 229193008258 probable transmembrane helix predicted by TMHMM2.0 229193008259 probable transmembrane helix predicted by TMHMM2.0 229193008260 probable transmembrane helix predicted by TMHMM2.0 229193008261 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 229193008262 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 229193008263 putative active site [active] 229193008264 catalytic site [active] 229193008265 putative metal binding site [ion binding]; other site 229193008266 probable transmembrane helix predicted by TMHMM2.0 229193008267 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 229193008268 hypothetical protein; Provisional; Region: PRK11622 229193008269 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 229193008270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193008271 dimer interface [polypeptide binding]; other site 229193008272 conserved gate region; other site 229193008273 putative PBP binding loops; other site 229193008274 ABC-ATPase subunit interface; other site 229193008275 probable transmembrane helix predicted by TMHMM2.0 229193008276 probable transmembrane helix predicted by TMHMM2.0 229193008277 probable transmembrane helix predicted by TMHMM2.0 229193008278 probable transmembrane helix predicted by TMHMM2.0 229193008279 probable transmembrane helix predicted by TMHMM2.0 229193008280 probable transmembrane helix predicted by TMHMM2.0 229193008281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193008282 dimer interface [polypeptide binding]; other site 229193008283 conserved gate region; other site 229193008284 putative PBP binding loops; other site 229193008285 ABC-ATPase subunit interface; other site 229193008286 probable transmembrane helix predicted by TMHMM2.0 229193008287 probable transmembrane helix predicted by TMHMM2.0 229193008288 probable transmembrane helix predicted by TMHMM2.0 229193008289 probable transmembrane helix predicted by TMHMM2.0 229193008290 probable transmembrane helix predicted by TMHMM2.0 229193008291 probable transmembrane helix predicted by TMHMM2.0 229193008292 Contains ABC transporter (Interpro|IPR003439, (GO:0016020)) 229193008293 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193008294 Contains ATP/GTP-binding site motif A (P-loop) (Interpro|IPR001687, (GO:0005524)) 229193008295 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 229193008296 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 229193008297 active site 229193008298 catalytic site [active] 229193008299 Transcriptional regulators [Transcription]; Region: MarR; COG1846 229193008300 MarR family; Region: MarR_2; pfam12802 229193008301 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 229193008302 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 229193008303 putative hydrolase; Validated; Region: PRK09248 229193008304 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 229193008305 active site 229193008306 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 229193008307 lipoprotein; Provisional; Region: PRK10598 229193008308 multidrug resistance protein MdtH; Provisional; Region: PRK11646 229193008309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193008310 putative substrate translocation pore; other site 229193008311 probable transmembrane helix predicted by TMHMM2.0 229193008312 probable transmembrane helix predicted by TMHMM2.0 229193008313 probable transmembrane helix predicted by TMHMM2.0 229193008314 probable transmembrane helix predicted by TMHMM2.0 229193008315 probable transmembrane helix predicted by TMHMM2.0 229193008316 probable transmembrane helix predicted by TMHMM2.0 229193008317 probable transmembrane helix predicted by TMHMM2.0 229193008318 probable transmembrane helix predicted by TMHMM2.0 229193008319 probable transmembrane helix predicted by TMHMM2.0 229193008320 probable transmembrane helix predicted by TMHMM2.0 229193008321 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 229193008322 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 229193008323 hypothetical protein; Provisional; Region: PRK11239 229193008324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 229193008325 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 229193008326 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 229193008327 HMMPfam match to entry PF04337 DUF480, E-value 2.3e-105 229193008328 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 229193008329 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 229193008330 probable transmembrane helix predicted by TMHMM2.0 229193008331 probable transmembrane helix predicted by TMHMM2.0 229193008332 probable transmembrane helix predicted by TMHMM2.0 229193008333 probable transmembrane helix predicted by TMHMM2.0 229193008334 probable transmembrane helix predicted by TMHMM2.0 229193008335 probable transmembrane helix predicted by TMHMM2.0 229193008336 probable transmembrane helix predicted by TMHMM2.0 229193008337 probable transmembrane helix predicted by TMHMM2.0 229193008338 probable transmembrane helix predicted by TMHMM2.0 229193008339 probable transmembrane helix predicted by TMHMM2.0 229193008340 probable transmembrane helix predicted by TMHMM2.0 229193008341 probable transmembrane helix predicted by TMHMM2.0 229193008342 probable transmembrane helix predicted by TMHMM2.0 229193008343 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 229193008344 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 229193008345 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 229193008346 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 229193008347 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 229193008348 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 229193008349 active site 229193008350 HIGH motif; other site 229193008351 KMSK motif region; other site 229193008352 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 229193008353 tRNA binding surface [nucleotide binding]; other site 229193008354 anticodon binding site; other site 229193008355 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 229193008356 putative metal binding site [ion binding]; other site 229193008357 copper homeostasis protein CutC; Provisional; Region: PRK11572 229193008358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193008359 S-adenosylmethionine binding site [chemical binding]; other site 229193008360 HMMTigr match to entry TIGR00452 TIGR00452, E-value 2.6e-215 229193008361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193008362 S-adenosylmethionine binding site [chemical binding]; other site 229193008363 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 229193008364 BlastProDom match to entry PD009387 sp_P76289_YECN_ECOLI, E-value 2e-37 229193008365 hypothetical protein; Provisional; Region: PRK10302 229193008366 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 229193008367 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 229193008368 dimer interface [polypeptide binding]; other site 229193008369 anticodon binding site; other site 229193008370 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 229193008371 homodimer interface [polypeptide binding]; other site 229193008372 motif 1; other site 229193008373 active site 229193008374 motif 2; other site 229193008375 GAD domain; Region: GAD; pfam02938 229193008376 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 229193008377 active site 229193008378 motif 3; other site 229193008379 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 229193008380 nudix motif; other site 229193008381 hypothetical protein; Validated; Region: PRK00110 229193008382 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 229193008383 active site 229193008384 putative DNA-binding cleft [nucleotide binding]; other site 229193008385 dimer interface [polypeptide binding]; other site 229193008386 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 229193008387 RuvA N terminal domain; Region: RuvA_N; pfam01330 229193008388 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 229193008389 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 229193008390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193008391 Walker A motif; other site 229193008392 ATP binding site [chemical binding]; other site 229193008393 Walker B motif; other site 229193008394 arginine finger; other site 229193008395 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 229193008396 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 229193008397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193008398 ABC-ATPase subunit interface; other site 229193008399 dimer interface [polypeptide binding]; other site 229193008400 putative PBP binding regions; other site 229193008401 probable transmembrane helix predicted by TMHMM2.0 229193008402 probable transmembrane helix predicted by TMHMM2.0 229193008403 probable transmembrane helix predicted by TMHMM2.0 229193008404 probable transmembrane helix predicted by TMHMM2.0 229193008405 probable transmembrane helix predicted by TMHMM2.0 229193008406 probable transmembrane helix predicted by TMHMM2.0 229193008407 probable transmembrane helix predicted by TMHMM2.0 229193008408 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 229193008409 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 229193008410 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 229193008411 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 229193008412 metal binding site [ion binding]; metal-binding site 229193008413 probable transmembrane helix predicted by TMHMM2.0 229193008414 putative peptidase; Provisional; Region: PRK11649 229193008415 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 229193008416 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 229193008417 Peptidase family M23; Region: Peptidase_M23; pfam01551 229193008418 probable transmembrane helix predicted by TMHMM2.0 229193008419 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 229193008420 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 229193008421 putative acyl-acceptor binding pocket; other site 229193008422 probable transmembrane helix predicted by TMHMM2.0 229193008423 pyruvate kinase; Provisional; Region: PRK05826 229193008424 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 229193008425 domain interfaces; other site 229193008426 active site 229193008427 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 229193008428 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 229193008429 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 229193008430 putative active site [active] 229193008431 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 229193008432 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 229193008433 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 229193008434 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 229193008435 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 229193008436 active site 229193008437 intersubunit interface [polypeptide binding]; other site 229193008438 catalytic residue [active] 229193008439 BlastProDom match to entry PD006286 sp_P10177_ALKH_ECOLI, E-value 3e-29 229193008440 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 229193008441 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 229193008442 probable transmembrane helix predicted by TMHMM2.0 229193008443 probable transmembrane helix predicted by TMHMM2.0 229193008444 probable transmembrane helix predicted by TMHMM2.0 229193008445 probable transmembrane helix predicted by TMHMM2.0 229193008446 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 229193008447 homotrimer interaction site [polypeptide binding]; other site 229193008448 putative active site [active] 229193008449 BlastProDom match to entry PD002429 sp_P76258_YOAB_ECOLI, E-value 1e-26 229193008450 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 229193008451 DEAD/DEAH box helicase; Region: DEAD; pfam00270 229193008452 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 229193008453 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 229193008454 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 229193008455 Glycoprotease family; Region: Peptidase_M22; pfam00814 229193008456 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 229193008457 probable transmembrane helix predicted by TMHMM2.0 229193008458 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 229193008459 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 229193008460 acyl-activating enzyme (AAE) consensus motif; other site 229193008461 putative AMP binding site [chemical binding]; other site 229193008462 putative active site [active] 229193008463 putative CoA binding site [chemical binding]; other site 229193008464 ribonuclease D; Provisional; Region: PRK10829 229193008465 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 229193008466 catalytic site [active] 229193008467 putative active site [active] 229193008468 putative substrate binding site [chemical binding]; other site 229193008469 HRDC domain; Region: HRDC; pfam00570 229193008470 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 229193008471 cell division inhibitor MinD; Provisional; Region: PRK10818 229193008472 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 229193008473 Switch I; other site 229193008474 Switch II; other site 229193008475 septum formation inhibitor; Reviewed; Region: minC; PRK03511 229193008476 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 229193008477 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 229193008478 HMMPfam match to entry PF05209 MinC_N, E-value 7e-42 229193008479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 229193008480 HMMPfam match to entry PF05166 DUF709, E-value 1.6e-48 229193008481 lytic murein transglycosylase; Region: MltB_2; TIGR02283 229193008482 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 229193008483 N-acetyl-D-glucosamine binding site [chemical binding]; other site 229193008484 catalytic residue [active] 229193008485 hypothetical protein; Provisional; Region: PRK10691 229193008486 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 229193008487 hypothetical protein; Provisional; Region: PRK05170 229193008488 int3; similar to Escherichia coli O157:H7 integrase Int TR:Q9EY96 (EMBL:AP000400) (428 aa) and to Escherichia coli lambdoid prophage RAC integrase IntR SW:INTR_ECOLI (P76056) (411 aa); disrupted by IS100 229193008489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193008490 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193008491 DNA-binding interface [nucleotide binding]; DNA binding site 229193008492 Integrase core domain; Region: rve; pfam00665 229193008493 transposase/IS protein; Provisional; Region: PRK09183 229193008494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193008495 Walker A motif; other site 229193008496 ATP binding site [chemical binding]; other site 229193008497 Walker B motif; other site 229193008498 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 229193008499 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 229193008500 NinB protein; Region: NinB; pfam05772 229193008501 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 229193008502 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 229193008503 BlastProDom match to entry PD031922 sp_O48429_REGQ_BPH19, E-value 6e-42 229193008504 Ash protein family; Region: Phage_ASH; pfam10554 229193008505 Prophage antirepressor [Transcription]; Region: COG3617 229193008506 BRO family, N-terminal domain; Region: Bro-N; smart01040 229193008507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193008508 MULE transposase domain; Region: MULE; pfam10551 229193008509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193008510 putative substrate translocation pore; other site 229193008511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 229193008512 probable transmembrane helix predicted by TMHMM2.0 229193008513 probable transmembrane helix predicted by TMHMM2.0 229193008514 probable transmembrane helix predicted by TMHMM2.0 229193008515 probable transmembrane helix predicted by TMHMM2.0 229193008516 probable transmembrane helix predicted by TMHMM2.0 229193008517 probable transmembrane helix predicted by TMHMM2.0 229193008518 probable transmembrane helix predicted by TMHMM2.0 229193008519 probable transmembrane helix predicted by TMHMM2.0 229193008520 probable transmembrane helix predicted by TMHMM2.0 229193008521 probable transmembrane helix predicted by TMHMM2.0 229193008522 probable transmembrane helix predicted by TMHMM2.0 229193008523 probable transmembrane helix predicted by TMHMM2.0 229193008524 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 229193008525 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 229193008526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193008527 catalytic residue [active] 229193008528 disulfide bond formation protein B; Provisional; Region: PRK01749 229193008529 probable transmembrane helix predicted by TMHMM2.0 229193008530 probable transmembrane helix predicted by TMHMM2.0 229193008531 probable transmembrane helix predicted by TMHMM2.0 229193008532 probable transmembrane helix predicted by TMHMM2.0 229193008533 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 229193008534 probable transmembrane helix predicted by TMHMM2.0 229193008535 probable transmembrane helix predicted by TMHMM2.0 229193008536 probable transmembrane helix predicted by TMHMM2.0 229193008537 probable transmembrane helix predicted by TMHMM2.0 229193008538 probable transmembrane helix predicted by TMHMM2.0 229193008539 probable transmembrane helix predicted by TMHMM2.0 229193008540 probable transmembrane helix predicted by TMHMM2.0 229193008541 probable transmembrane helix predicted by TMHMM2.0 229193008542 probable transmembrane helix predicted by TMHMM2.0 229193008543 fatty acid metabolism regulator; Provisional; Region: PRK04984 229193008544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 229193008545 DNA-binding site [nucleotide binding]; DNA binding site 229193008546 FadR C-terminal domain; Region: FadR_C; pfam07840 229193008547 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 229193008548 SpoVR family protein; Provisional; Region: PRK11767 229193008549 HMMPfam match to entry PF04293 SpoVR, E-value 0 229193008550 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 229193008551 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 229193008552 hydroxyglutarate oxidase; Provisional; Region: PRK11728 229193008553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193008554 putative substrate translocation pore; other site 229193008555 Major Facilitator Superfamily; Region: MFS_1; pfam07690 229193008556 probable transmembrane helix predicted by TMHMM2.0 229193008557 probable transmembrane helix predicted by TMHMM2.0 229193008558 probable transmembrane helix predicted by TMHMM2.0 229193008559 probable transmembrane helix predicted by TMHMM2.0 229193008560 probable transmembrane helix predicted by TMHMM2.0 229193008561 probable transmembrane helix predicted by TMHMM2.0 229193008562 probable transmembrane helix predicted by TMHMM2.0 229193008563 probable transmembrane helix predicted by TMHMM2.0 229193008564 probable transmembrane helix predicted by TMHMM2.0 229193008565 probable transmembrane helix predicted by TMHMM2.0 229193008566 probable transmembrane helix predicted by TMHMM2.0 229193008567 Pirin-related protein [General function prediction only]; Region: COG1741 229193008568 Pirin; Region: Pirin; pfam02678 229193008569 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 229193008570 LysR family transcriptional regulator; Provisional; Region: PRK14997 229193008571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193008572 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 229193008573 putative effector binding pocket; other site 229193008574 putative dimerization interface [polypeptide binding]; other site 229193008575 EamA-like transporter family; Region: EamA; pfam00892 229193008576 ProfileScan match to entry PS50316 HIS_RICH, E-value 29.623 229193008577 probable transmembrane helix predicted by TMHMM2.0 229193008578 probable transmembrane helix predicted by TMHMM2.0 229193008579 probable transmembrane helix predicted by TMHMM2.0 229193008580 probable transmembrane helix predicted by TMHMM2.0 229193008581 probable transmembrane helix predicted by TMHMM2.0 229193008582 probable transmembrane helix predicted by TMHMM2.0 229193008583 probable transmembrane helix predicted by TMHMM2.0 229193008584 probable transmembrane helix predicted by TMHMM2.0 229193008585 probable transmembrane helix predicted by TMHMM2.0 229193008586 probable transmembrane helix predicted by TMHMM2.0 229193008587 Uncharacterized conserved protein [Function unknown]; Region: COG2718 229193008588 PrkA family serine protein kinase; Provisional; Region: PRK15455 229193008589 AAA ATPase domain; Region: AAA_16; pfam13191 229193008590 Walker A motif; other site 229193008591 ATP binding site [chemical binding]; other site 229193008592 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 229193008593 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 229193008594 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 229193008595 active site 229193008596 phosphate binding residues; other site 229193008597 catalytic residues [active] 229193008598 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 229193008599 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 229193008600 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 229193008601 methionine sulfoxide reductase B; Provisional; Region: PRK00222 229193008602 SelR domain; Region: SelR; pfam01641 229193008603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 229193008604 Isochorismatase family; Region: Isochorismatase; pfam00857 229193008605 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 229193008606 catalytic triad [active] 229193008607 metal binding site [ion binding]; metal-binding site 229193008608 conserved cis-peptide bond; other site 229193008609 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 229193008610 active site 229193008611 homodimer interface [polypeptide binding]; other site 229193008612 protease 4; Provisional; Region: PRK10949 229193008613 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 229193008614 tandem repeat interface [polypeptide binding]; other site 229193008615 oligomer interface [polypeptide binding]; other site 229193008616 active site residues [active] 229193008617 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 229193008618 tandem repeat interface [polypeptide binding]; other site 229193008619 oligomer interface [polypeptide binding]; other site 229193008620 active site residues [active] 229193008621 probable transmembrane helix predicted by TMHMM2.0 229193008622 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 229193008623 putative FMN binding site [chemical binding]; other site 229193008624 selenophosphate synthetase; Provisional; Region: PRK00943 229193008625 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 229193008626 dimerization interface [polypeptide binding]; other site 229193008627 putative ATP binding site [chemical binding]; other site 229193008628 DNA topoisomerase III; Provisional; Region: PRK07726 229193008629 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 229193008630 active site 229193008631 putative interdomain interaction site [polypeptide binding]; other site 229193008632 putative metal-binding site [ion binding]; other site 229193008633 putative nucleotide binding site [chemical binding]; other site 229193008634 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 229193008635 domain I; other site 229193008636 DNA binding groove [nucleotide binding] 229193008637 phosphate binding site [ion binding]; other site 229193008638 domain II; other site 229193008639 domain III; other site 229193008640 nucleotide binding site [chemical binding]; other site 229193008641 catalytic site [active] 229193008642 domain IV; other site 229193008643 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 229193008644 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 229193008645 active site 229193008646 8-oxo-dGMP binding site [chemical binding]; other site 229193008647 nudix motif; other site 229193008648 metal binding site [ion binding]; metal-binding site 229193008649 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 229193008650 putative catalytic site [active] 229193008651 putative phosphate binding site [ion binding]; other site 229193008652 active site 229193008653 metal binding site A [ion binding]; metal-binding site 229193008654 DNA binding site [nucleotide binding] 229193008655 putative AP binding site [nucleotide binding]; other site 229193008656 putative metal binding site B [ion binding]; other site 229193008657 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193008658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193008659 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 229193008660 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 229193008661 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 229193008662 putative active site [active] 229193008663 putative substrate binding site [chemical binding]; other site 229193008664 putative cosubstrate binding site; other site 229193008665 catalytic site [active] 229193008666 SEC-C motif; Region: SEC-C; pfam02810 229193008667 hypothetical protein; Provisional; Region: PRK04233 229193008668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193008669 active site 229193008670 response regulator of RpoS; Provisional; Region: PRK10693 229193008671 phosphorylation site [posttranslational modification] 229193008672 intermolecular recognition site; other site 229193008673 dimerization interface [polypeptide binding]; other site 229193008674 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 229193008675 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 229193008676 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 229193008677 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 229193008678 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 229193008679 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 229193008680 thymidine kinase; Provisional; Region: PRK04296 229193008681 BlastProDom match to entry PD002207 sp_P57926_KITH_PASMU, E-value 3e-70 229193008682 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 229193008683 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 229193008684 putative catalytic cysteine [active] 229193008685 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 229193008686 putative active site [active] 229193008687 metal binding site [ion binding]; metal-binding site 229193008688 probable transmembrane helix predicted by TMHMM2.0 229193008689 hypothetical protein; Provisional; Region: PRK11111 229193008690 probable transmembrane helix predicted by TMHMM2.0 229193008691 BlastProDom match to entry PD006289 sp_P25743_YCHE_ECOLI, E-value 7e-87 229193008692 probable transmembrane helix predicted by TMHMM2.0 229193008693 probable transmembrane helix predicted by TMHMM2.0 229193008694 probable transmembrane helix predicted by TMHMM2.0 229193008695 probable transmembrane helix predicted by TMHMM2.0 229193008696 probable transmembrane helix predicted by TMHMM2.0 229193008697 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 229193008698 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 229193008699 peptide binding site [polypeptide binding]; other site 229193008700 probable transmembrane helix predicted by TMHMM2.0 229193008701 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 229193008702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193008703 dimer interface [polypeptide binding]; other site 229193008704 conserved gate region; other site 229193008705 putative PBP binding loops; other site 229193008706 ABC-ATPase subunit interface; other site 229193008707 probable transmembrane helix predicted by TMHMM2.0 229193008708 probable transmembrane helix predicted by TMHMM2.0 229193008709 probable transmembrane helix predicted by TMHMM2.0 229193008710 probable transmembrane helix predicted by TMHMM2.0 229193008711 probable transmembrane helix predicted by TMHMM2.0 229193008712 probable transmembrane helix predicted by TMHMM2.0 229193008713 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 229193008714 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 229193008715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193008716 dimer interface [polypeptide binding]; other site 229193008717 conserved gate region; other site 229193008718 ABC-ATPase subunit interface; other site 229193008719 probable transmembrane helix predicted by TMHMM2.0 229193008720 probable transmembrane helix predicted by TMHMM2.0 229193008721 probable transmembrane helix predicted by TMHMM2.0 229193008722 probable transmembrane helix predicted by TMHMM2.0 229193008723 probable transmembrane helix predicted by TMHMM2.0 229193008724 probable transmembrane helix predicted by TMHMM2.0 229193008725 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 229193008726 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193008727 Walker A/P-loop; other site 229193008728 ATP binding site [chemical binding]; other site 229193008729 Q-loop/lid; other site 229193008730 ABC transporter signature motif; other site 229193008731 Walker B; other site 229193008732 D-loop; other site 229193008733 H-loop/switch region; other site 229193008734 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 229193008735 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 229193008736 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193008737 Walker A/P-loop; other site 229193008738 ATP binding site [chemical binding]; other site 229193008739 Q-loop/lid; other site 229193008740 ABC transporter signature motif; other site 229193008741 Walker B; other site 229193008742 D-loop; other site 229193008743 H-loop/switch region; other site 229193008744 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 229193008745 dsDNA-mimic protein; Reviewed; Region: PRK05094 229193008746 HMMPfam match to entry PF04269 DUF440, E-value 1e-40 229193008747 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 229193008748 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 229193008749 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 229193008750 putative active site [active] 229193008751 catalytic site [active] 229193008752 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 229193008753 putative active site [active] 229193008754 catalytic site [active] 229193008755 probable transmembrane helix predicted by TMHMM2.0 229193008756 probable transmembrane helix predicted by TMHMM2.0 229193008757 Yersinia protein of unknown function (DUF3831); Region: DUF3831; pfam12908 229193008758 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 229193008759 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 229193008760 YciI-like protein; Reviewed; Region: PRK11370 229193008761 transport protein TonB; Provisional; Region: PRK10819 229193008762 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 229193008763 probable transmembrane helix predicted by TMHMM2.0 229193008764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193008765 MULE transposase domain; Region: MULE; pfam10551 229193008766 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 229193008767 intracellular septation protein A; Reviewed; Region: PRK00259 229193008768 HMMPfam match to entry PF04279 IspA, E-value 3.1e-110 229193008769 probable transmembrane helix predicted by TMHMM2.0 229193008770 probable transmembrane helix predicted by TMHMM2.0 229193008771 probable transmembrane helix predicted by TMHMM2.0 229193008772 probable transmembrane helix predicted by TMHMM2.0 229193008773 probable transmembrane helix predicted by TMHMM2.0 229193008774 hypothetical protein; Provisional; Region: PRK02868 229193008775 probable transmembrane helix predicted by TMHMM2.0 229193008776 probable transmembrane helix predicted by TMHMM2.0 229193008777 probable transmembrane helix predicted by TMHMM2.0 229193008778 probable transmembrane helix predicted by TMHMM2.0 229193008779 probable transmembrane helix predicted by TMHMM2.0 229193008780 probable transmembrane helix predicted by TMHMM2.0 229193008781 outer membrane protein W; Provisional; Region: PRK10959 229193008782 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 229193008783 BON domain; Region: BON; pfam04972 229193008784 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 229193008785 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 229193008786 substrate binding site [chemical binding]; other site 229193008787 active site 229193008788 catalytic residues [active] 229193008789 heterodimer interface [polypeptide binding]; other site 229193008790 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 229193008791 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 229193008792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193008793 catalytic residue [active] 229193008794 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 229193008795 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 229193008796 active site 229193008797 ribulose/triose binding site [chemical binding]; other site 229193008798 phosphate binding site [ion binding]; other site 229193008799 substrate (anthranilate) binding pocket [chemical binding]; other site 229193008800 product (indole) binding pocket [chemical binding]; other site 229193008801 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 229193008802 active site 229193008803 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 229193008804 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 229193008805 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 229193008806 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 229193008807 Glutamine amidotransferase class-I; Region: GATase; pfam00117 229193008808 glutamine binding [chemical binding]; other site 229193008809 catalytic triad [active] 229193008810 anthranilate synthase component I; Provisional; Region: PRK13564 229193008811 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 229193008812 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 229193008813 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 229193008814 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 229193008815 active site 229193008816 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 229193008817 hypothetical protein; Provisional; Region: PRK11630 229193008818 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 229193008819 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 229193008820 RNA binding surface [nucleotide binding]; other site 229193008821 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 229193008822 probable active site [active] 229193008823 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 229193008824 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 229193008825 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 229193008826 homodimer interface [polypeptide binding]; other site 229193008827 Walker A motif; other site 229193008828 ATP binding site [chemical binding]; other site 229193008829 hydroxycobalamin binding site [chemical binding]; other site 229193008830 Walker B motif; other site 229193008831 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 229193008832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 229193008833 NAD(P) binding site [chemical binding]; other site 229193008834 active site 229193008835 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 229193008836 putative inner membrane peptidase; Provisional; Region: PRK11778 229193008837 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 229193008838 tandem repeat interface [polypeptide binding]; other site 229193008839 oligomer interface [polypeptide binding]; other site 229193008840 active site residues [active] 229193008841 probable transmembrane helix predicted by TMHMM2.0 229193008842 hypothetical protein; Provisional; Region: PRK11037 229193008843 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 229193008844 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 229193008845 active site 229193008846 interdomain interaction site; other site 229193008847 putative metal-binding site [ion binding]; other site 229193008848 nucleotide binding site [chemical binding]; other site 229193008849 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 229193008850 domain I; other site 229193008851 DNA binding groove [nucleotide binding] 229193008852 phosphate binding site [ion binding]; other site 229193008853 domain II; other site 229193008854 domain III; other site 229193008855 nucleotide binding site [chemical binding]; other site 229193008856 catalytic site [active] 229193008857 domain IV; other site 229193008858 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 229193008859 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 229193008860 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 229193008861 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 229193008862 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 229193008863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193008864 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 229193008865 substrate binding site [chemical binding]; other site 229193008866 putative dimerization interface [polypeptide binding]; other site 229193008867 aconitate hydratase; Validated; Region: PRK09277 229193008868 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 229193008869 substrate binding site [chemical binding]; other site 229193008870 ligand binding site [chemical binding]; other site 229193008871 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 229193008872 substrate binding site [chemical binding]; other site 229193008873 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 229193008874 dimerization interface [polypeptide binding]; other site 229193008875 active site 229193008876 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 229193008877 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 229193008878 active site 229193008879 probable transmembrane helix predicted by TMHMM2.0 229193008880 probable transmembrane helix predicted by TMHMM2.0 229193008881 probable transmembrane helix predicted by TMHMM2.0 229193008882 probable transmembrane helix predicted by TMHMM2.0 229193008883 probable transmembrane helix predicted by TMHMM2.0 229193008884 probable transmembrane helix predicted by TMHMM2.0 229193008885 Predicted membrane protein [Function unknown]; Region: COG3771 229193008886 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 229193008887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 229193008888 TPR motif; other site 229193008889 binding surface 229193008890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 229193008891 binding surface 229193008892 TPR motif; other site 229193008893 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 229193008894 active site 229193008895 dimer interface [polypeptide binding]; other site 229193008896 translation initiation factor Sui1; Validated; Region: PRK06824 229193008897 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 229193008898 putative rRNA binding site [nucleotide binding]; other site 229193008899 lipoprotein; Provisional; Region: PRK10540 229193008900 probable transmembrane helix predicted by TMHMM2.0 229193008901 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 229193008902 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 229193008903 intersubunit interface [polypeptide binding]; other site 229193008904 active site 229193008905 Zn2+ binding site [ion binding]; other site 229193008906 Uncharacterized conserved protein [Function unknown]; Region: COG5460 229193008907 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 229193008908 active site 229193008909 intersubunit interactions; other site 229193008910 catalytic residue [active] 229193008911 Uncharacterized small protein [Function unknown]; Region: COG2879 229193008912 HMMPfam match to entry PF04328 DUF466, E-value 6.9e-17 229193008913 carbon starvation protein A; Provisional; Region: PRK15015 229193008914 Carbon starvation protein CstA; Region: CstA; pfam02554 229193008915 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 229193008916 probable transmembrane helix predicted by TMHMM2.0 229193008917 probable transmembrane helix predicted by TMHMM2.0 229193008918 probable transmembrane helix predicted by TMHMM2.0 229193008919 probable transmembrane helix predicted by TMHMM2.0 229193008920 probable transmembrane helix predicted by TMHMM2.0 229193008921 probable transmembrane helix predicted by TMHMM2.0 229193008922 probable transmembrane helix predicted by TMHMM2.0 229193008923 probable transmembrane helix predicted by TMHMM2.0 229193008924 probable transmembrane helix predicted by TMHMM2.0 229193008925 probable transmembrane helix predicted by TMHMM2.0 229193008926 probable transmembrane helix predicted by TMHMM2.0 229193008927 probable transmembrane helix predicted by TMHMM2.0 229193008928 probable transmembrane helix predicted by TMHMM2.0 229193008929 probable transmembrane helix predicted by TMHMM2.0 229193008930 probable transmembrane helix predicted by TMHMM2.0 229193008931 probable transmembrane helix predicted by TMHMM2.0 229193008932 exoribonuclease II; Provisional; Region: PRK05054 229193008933 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 229193008934 RNB domain; Region: RNB; pfam00773 229193008935 S1 RNA binding domain; Region: S1; pfam00575 229193008936 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 229193008937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193008938 putative substrate translocation pore; other site 229193008939 probable transmembrane helix predicted by TMHMM2.0 229193008940 probable transmembrane helix predicted by TMHMM2.0 229193008941 probable transmembrane helix predicted by TMHMM2.0 229193008942 probable transmembrane helix predicted by TMHMM2.0 229193008943 probable transmembrane helix predicted by TMHMM2.0 229193008944 probable transmembrane helix predicted by TMHMM2.0 229193008945 probable transmembrane helix predicted by TMHMM2.0 229193008946 probable transmembrane helix predicted by TMHMM2.0 229193008947 probable transmembrane helix predicted by TMHMM2.0 229193008948 probable transmembrane helix predicted by TMHMM2.0 229193008949 probable transmembrane helix predicted by TMHMM2.0 229193008950 probable transmembrane helix predicted by TMHMM2.0 229193008951 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 229193008952 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 229193008953 putative NAD(P) binding site [chemical binding]; other site 229193008954 active site 229193008955 putative substrate binding site [chemical binding]; other site 229193008956 endonuclease III; Provisional; Region: PRK10702 229193008957 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 229193008958 minor groove reading motif; other site 229193008959 helix-hairpin-helix signature motif; other site 229193008960 substrate binding pocket [chemical binding]; other site 229193008961 active site 229193008962 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 229193008963 electron transport complex RsxE subunit; Provisional; Region: PRK12405 229193008964 probable transmembrane helix predicted by TMHMM2.0 229193008965 probable transmembrane helix predicted by TMHMM2.0 229193008966 probable transmembrane helix predicted by TMHMM2.0 229193008967 probable transmembrane helix predicted by TMHMM2.0 229193008968 probable transmembrane helix predicted by TMHMM2.0 229193008969 electron transport complex protein RnfG; Validated; Region: PRK01908 229193008970 HMMPfam match to entry PF04205 FMN_bind, E-value 6.8e-42 229193008971 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 229193008972 probable transmembrane helix predicted by TMHMM2.0 229193008973 probable transmembrane helix predicted by TMHMM2.0 229193008974 probable transmembrane helix predicted by TMHMM2.0 229193008975 probable transmembrane helix predicted by TMHMM2.0 229193008976 probable transmembrane helix predicted by TMHMM2.0 229193008977 probable transmembrane helix predicted by TMHMM2.0 229193008978 probable transmembrane helix predicted by TMHMM2.0 229193008979 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 229193008980 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 229193008981 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 229193008982 SLBB domain; Region: SLBB; pfam10531 229193008983 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 229193008984 ProfileScan match to entry PS50310 ALA_RICH, E-value 18.406 229193008985 electron transport complex protein RnfB; Provisional; Region: PRK05113 229193008986 Putative Fe-S cluster; Region: FeS; pfam04060 229193008987 4Fe-4S binding domain; Region: Fer4; pfam00037 229193008988 HMMPfam match to entry PF04060 FeS, E-value 6.1e-15 229193008989 probable transmembrane helix predicted by TMHMM2.0 229193008990 electron transport complex protein RsxA; Provisional; Region: PRK05151 229193008991 probable transmembrane helix predicted by TMHMM2.0 229193008992 probable transmembrane helix predicted by TMHMM2.0 229193008993 probable transmembrane helix predicted by TMHMM2.0 229193008994 probable transmembrane helix predicted by TMHMM2.0 229193008995 probable transmembrane helix predicted by TMHMM2.0 229193008996 probable transmembrane helix predicted by TMHMM2.0 229193008997 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 229193008998 probable transmembrane helix predicted by TMHMM2.0 229193008999 probable transmembrane helix predicted by TMHMM2.0 229193009000 probable transmembrane helix predicted by TMHMM2.0 229193009001 probable transmembrane helix predicted by TMHMM2.0 229193009002 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 229193009003 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 229193009004 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 229193009005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193009006 Walker A/P-loop; other site 229193009007 ATP binding site [chemical binding]; other site 229193009008 Q-loop/lid; other site 229193009009 ABC transporter signature motif; other site 229193009010 Walker B; other site 229193009011 D-loop; other site 229193009012 H-loop/switch region; other site 229193009013 probable transmembrane helix predicted by TMHMM2.0 229193009014 probable transmembrane helix predicted by TMHMM2.0 229193009015 probable transmembrane helix predicted by TMHMM2.0 229193009016 probable transmembrane helix predicted by TMHMM2.0 229193009017 probable transmembrane helix predicted by TMHMM2.0 229193009018 L-arabinose isomerase; Provisional; Region: PRK02929 229193009019 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 229193009020 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 229193009021 trimer interface [polypeptide binding]; other site 229193009022 putative substrate binding site [chemical binding]; other site 229193009023 putative metal binding site [ion binding]; other site 229193009024 ribulokinase; Provisional; Region: PRK04123 229193009025 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 229193009026 N- and C-terminal domain interface [polypeptide binding]; other site 229193009027 active site 229193009028 MgATP binding site [chemical binding]; other site 229193009029 catalytic site [active] 229193009030 metal binding site [ion binding]; metal-binding site 229193009031 carbohydrate binding site [chemical binding]; other site 229193009032 homodimer interface [polypeptide binding]; other site 229193009033 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 229193009034 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 229193009035 ligand binding site [chemical binding]; other site 229193009036 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 229193009037 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193009038 Walker A/P-loop; other site 229193009039 ATP binding site [chemical binding]; other site 229193009040 Q-loop/lid; other site 229193009041 ABC transporter signature motif; other site 229193009042 Walker B; other site 229193009043 D-loop; other site 229193009044 H-loop/switch region; other site 229193009045 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193009046 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193009047 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193009048 TM-ABC transporter signature motif; other site 229193009049 probable transmembrane helix predicted by TMHMM2.0 229193009050 probable transmembrane helix predicted by TMHMM2.0 229193009051 probable transmembrane helix predicted by TMHMM2.0 229193009052 probable transmembrane helix predicted by TMHMM2.0 229193009053 probable transmembrane helix predicted by TMHMM2.0 229193009054 probable transmembrane helix predicted by TMHMM2.0 229193009055 probable transmembrane helix predicted by TMHMM2.0 229193009056 probable transmembrane helix predicted by TMHMM2.0 229193009057 probable transmembrane helix predicted by TMHMM2.0 229193009058 probable transmembrane helix predicted by TMHMM2.0 229193009059 putative oxidoreductase; Provisional; Region: PRK11579 229193009060 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 229193009061 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 229193009062 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 229193009063 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 229193009064 probable transmembrane helix predicted by TMHMM2.0 229193009065 probable transmembrane helix predicted by TMHMM2.0 229193009066 probable transmembrane helix predicted by TMHMM2.0 229193009067 probable transmembrane helix predicted by TMHMM2.0 229193009068 probable transmembrane helix predicted by TMHMM2.0 229193009069 probable transmembrane helix predicted by TMHMM2.0 229193009070 probable transmembrane helix predicted by TMHMM2.0 229193009071 probable transmembrane helix predicted by TMHMM2.0 229193009072 probable transmembrane helix predicted by TMHMM2.0 229193009073 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 229193009074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 229193009075 probable transmembrane helix predicted by TMHMM2.0 229193009076 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 229193009077 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 229193009078 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 229193009079 fumarate hydratase; Reviewed; Region: fumC; PRK00485 229193009080 Class II fumarases; Region: Fumarase_classII; cd01362 229193009081 active site 229193009082 tetramer interface [polypeptide binding]; other site 229193009083 DNA replication terminus site-binding protein; Region: rep_term_tus; TIGR02648 229193009084 probable transmembrane helix predicted by TMHMM2.0 229193009085 probable transmembrane helix predicted by TMHMM2.0 229193009086 probable transmembrane helix predicted by TMHMM2.0 229193009087 probable transmembrane helix predicted by TMHMM2.0 229193009088 probable transmembrane helix predicted by TMHMM2.0 229193009089 probable transmembrane helix predicted by TMHMM2.0 229193009090 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 229193009091 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 229193009092 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 229193009093 nucleotide binding site [chemical binding]; other site 229193009094 putative dithiobiotin synthetase; Provisional; Region: PRK12374 229193009095 AAA domain; Region: AAA_26; pfam13500 229193009096 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 229193009097 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 229193009098 Cl- selectivity filter; other site 229193009099 Cl- binding residues [ion binding]; other site 229193009100 pore gating glutamate residue; other site 229193009101 dimer interface [polypeptide binding]; other site 229193009102 probable transmembrane helix predicted by TMHMM2.0 229193009103 probable transmembrane helix predicted by TMHMM2.0 229193009104 probable transmembrane helix predicted by TMHMM2.0 229193009105 probable transmembrane helix predicted by TMHMM2.0 229193009106 probable transmembrane helix predicted by TMHMM2.0 229193009107 probable transmembrane helix predicted by TMHMM2.0 229193009108 probable transmembrane helix predicted by TMHMM2.0 229193009109 probable transmembrane helix predicted by TMHMM2.0 229193009110 probable transmembrane helix predicted by TMHMM2.0 229193009111 probable transmembrane helix predicted by TMHMM2.0 229193009112 probable transmembrane helix predicted by TMHMM2.0 229193009113 Transcriptional regulators [Transcription]; Region: PurR; COG1609 229193009114 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193009115 DNA binding site [nucleotide binding] 229193009116 domain linker motif; other site 229193009117 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 229193009118 dimerization interface (closed form) [polypeptide binding]; other site 229193009119 ligand binding site [chemical binding]; other site 229193009120 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 229193009121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 229193009122 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 229193009123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193009124 dimer interface [polypeptide binding]; other site 229193009125 conserved gate region; other site 229193009126 putative PBP binding loops; other site 229193009127 ABC-ATPase subunit interface; other site 229193009128 probable transmembrane helix predicted by TMHMM2.0 229193009129 probable transmembrane helix predicted by TMHMM2.0 229193009130 probable transmembrane helix predicted by TMHMM2.0 229193009131 probable transmembrane helix predicted by TMHMM2.0 229193009132 probable transmembrane helix predicted by TMHMM2.0 229193009133 probable transmembrane helix predicted by TMHMM2.0 229193009134 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 229193009135 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 229193009136 Walker A/P-loop; other site 229193009137 ATP binding site [chemical binding]; other site 229193009138 Q-loop/lid; other site 229193009139 ABC transporter signature motif; other site 229193009140 Walker B; other site 229193009141 D-loop; other site 229193009142 H-loop/switch region; other site 229193009143 AMP nucleosidase; Provisional; Region: PRK08292 229193009144 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 229193009145 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 229193009146 ribonuclease E; Reviewed; Region: rne; PRK10811 229193009147 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 229193009148 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 229193009149 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 229193009150 G1 box; other site 229193009151 GTP/Mg2+ binding site [chemical binding]; other site 229193009152 G2 box; other site 229193009153 Switch I region; other site 229193009154 G3 box; other site 229193009155 Switch II region; other site 229193009156 G4 box; other site 229193009157 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 229193009158 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 229193009159 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 229193009160 PYR/PP interface [polypeptide binding]; other site 229193009161 dimer interface [polypeptide binding]; other site 229193009162 TPP binding site [chemical binding]; other site 229193009163 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 229193009164 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 229193009165 TPP-binding site [chemical binding]; other site 229193009166 dimer interface [polypeptide binding]; other site 229193009167 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 229193009168 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 229193009169 putative valine binding site [chemical binding]; other site 229193009170 dimer interface [polypeptide binding]; other site 229193009171 dUMP phosphatase; Provisional; Region: PRK09449 229193009172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193009173 motif II; other site 229193009174 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 229193009175 tellurite resistance protein terB; Region: terB; cd07176 229193009176 putative metal binding site [ion binding]; other site 229193009177 probable transmembrane helix predicted by TMHMM2.0 229193009178 alkaline phosphatase; Provisional; Region: PRK10518 229193009179 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 229193009180 dimer interface [polypeptide binding]; other site 229193009181 active site 229193009182 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 229193009183 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 229193009184 DNA binding site [nucleotide binding] 229193009185 active site 229193009186 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 229193009187 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 229193009188 ligand binding site [chemical binding]; other site 229193009189 flexible hinge region; other site 229193009190 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 229193009191 putative switch regulator; other site 229193009192 non-specific DNA interactions [nucleotide binding]; other site 229193009193 DNA binding site [nucleotide binding] 229193009194 sequence specific DNA binding site [nucleotide binding]; other site 229193009195 putative cAMP binding site [chemical binding]; other site 229193009196 universal stress protein UspE; Provisional; Region: PRK11175 229193009197 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 229193009198 Ligand Binding Site [chemical binding]; other site 229193009199 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 229193009200 Ligand Binding Site [chemical binding]; other site 229193009201 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 229193009202 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 229193009203 probable transmembrane helix predicted by TMHMM2.0 229193009204 probable transmembrane helix predicted by TMHMM2.0 229193009205 probable transmembrane helix predicted by TMHMM2.0 229193009206 probable transmembrane helix predicted by TMHMM2.0 229193009207 probable transmembrane helix predicted by TMHMM2.0 229193009208 probable transmembrane helix predicted by TMHMM2.0 229193009209 probable transmembrane helix predicted by TMHMM2.0 229193009210 probable transmembrane helix predicted by TMHMM2.0 229193009211 probable transmembrane helix predicted by TMHMM2.0 229193009212 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 229193009213 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 229193009214 ligand binding site [chemical binding]; other site 229193009215 homodimer interface [polypeptide binding]; other site 229193009216 NAD(P) binding site [chemical binding]; other site 229193009217 trimer interface B [polypeptide binding]; other site 229193009218 trimer interface A [polypeptide binding]; other site 229193009219 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 229193009220 probable transmembrane helix predicted by TMHMM2.0 229193009221 probable transmembrane helix predicted by TMHMM2.0 229193009222 probable transmembrane helix predicted by TMHMM2.0 229193009223 probable transmembrane helix predicted by TMHMM2.0 229193009224 probable transmembrane helix predicted by TMHMM2.0 229193009225 HMMPfam match to entry PF05222 AlaDh_PNT_N, E-value 2.8e-73 229193009226 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 229193009227 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 229193009228 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 229193009229 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 229193009230 probable transmembrane helix predicted by TMHMM2.0 229193009231 probable transmembrane helix predicted by TMHMM2.0 229193009232 probable transmembrane helix predicted by TMHMM2.0 229193009233 probable transmembrane helix predicted by TMHMM2.0 229193009234 probable transmembrane helix predicted by TMHMM2.0 229193009235 probable transmembrane helix predicted by TMHMM2.0 229193009236 probable transmembrane helix predicted by TMHMM2.0 229193009237 probable transmembrane helix predicted by TMHMM2.0 229193009238 probable transmembrane helix predicted by TMHMM2.0 229193009239 probable transmembrane helix predicted by TMHMM2.0 229193009240 probable transmembrane helix predicted by TMHMM2.0 229193009241 probable transmembrane helix predicted by TMHMM2.0 229193009242 probable transmembrane helix predicted by TMHMM2.0 229193009243 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 229193009244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193009245 active site 229193009246 phosphorylation site [posttranslational modification] 229193009247 intermolecular recognition site; other site 229193009248 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193009249 DNA binding site [nucleotide binding] 229193009250 highly similar to Yersinia pestis CO92 YPO2309 and Yersinia pestis KIM y2140; disrupted by the insertion of IS100 element, insertion occurred near the C-terminus. It is not clear whether this insertion affects the function of the protein. 229193009251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193009252 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193009253 DNA-binding interface [nucleotide binding]; DNA binding site 229193009254 Integrase core domain; Region: rve; pfam00665 229193009255 transposase/IS protein; Provisional; Region: PRK09183 229193009256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193009257 Walker A motif; other site 229193009258 ATP binding site [chemical binding]; other site 229193009259 Walker B motif; other site 229193009260 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 229193009261 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 229193009262 active site 229193009263 Zn binding site [ion binding]; other site 229193009264 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193009265 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 229193009266 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 229193009267 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 229193009268 hypothetical protein; Provisional; Region: PRK03757 229193009269 HMMPfam match to entry PF04264 YceI, E-value 3e-78 229193009270 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 229193009271 probable transmembrane helix predicted by TMHMM2.0 229193009272 probable transmembrane helix predicted by TMHMM2.0 229193009273 probable transmembrane helix predicted by TMHMM2.0 229193009274 probable transmembrane helix predicted by TMHMM2.0 229193009275 probable transmembrane helix predicted by TMHMM2.0 229193009276 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 229193009277 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 229193009278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 229193009279 non-specific DNA binding site [nucleotide binding]; other site 229193009280 salt bridge; other site 229193009281 sequence-specific DNA binding site [nucleotide binding]; other site 229193009282 Phage-related protein [Function unknown]; Region: COG4679 229193009283 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 229193009284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 229193009285 ATP binding site [chemical binding]; other site 229193009286 putative Mg++ binding site [ion binding]; other site 229193009287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193009288 nucleotide binding region [chemical binding]; other site 229193009289 ATP-binding site [chemical binding]; other site 229193009290 Helicase associated domain (HA2); Region: HA2; pfam04408 229193009291 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 229193009292 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 229193009293 HMMPfam match to entry PF04408 HA2, E-value 2.6e-35 229193009294 azoreductase; Reviewed; Region: PRK00170 229193009295 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 229193009296 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 229193009297 MarR family; Region: MarR_2; pfam12802 229193009298 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 229193009299 HMMPfam match to entry PF04198 Sugar-bind, E-value 1.4e-80 229193009300 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 229193009301 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 229193009302 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 229193009303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 229193009304 probable transmembrane helix predicted by TMHMM2.0 229193009305 hypothetical protein; Provisional; Region: PRK10695 229193009306 probable transmembrane helix predicted by TMHMM2.0 229193009307 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 229193009308 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 229193009309 putative ligand binding site [chemical binding]; other site 229193009310 putative NAD binding site [chemical binding]; other site 229193009311 catalytic site [active] 229193009312 heat-inducible protein; Provisional; Region: PRK10449 229193009313 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 229193009314 Domain of unknown function (DUF333); Region: DUF333; pfam03891 229193009315 ProfileScan match to entry PS50321 ASN_RICH, E-value 9.044 229193009316 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 229193009317 MgtC family; Region: MgtC; pfam02308 229193009318 probable transmembrane helix predicted by TMHMM2.0 229193009319 probable transmembrane helix predicted by TMHMM2.0 229193009320 probable transmembrane helix predicted by TMHMM2.0 229193009321 probable transmembrane helix predicted by TMHMM2.0 229193009322 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 229193009323 probable transmembrane helix predicted by TMHMM2.0 229193009324 probable transmembrane helix predicted by TMHMM2.0 229193009325 probable transmembrane helix predicted by TMHMM2.0 229193009326 probable transmembrane helix predicted by TMHMM2.0 229193009327 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 229193009328 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 229193009329 dimer interface [polypeptide binding]; other site 229193009330 PYR/PP interface [polypeptide binding]; other site 229193009331 TPP binding site [chemical binding]; other site 229193009332 substrate binding site [chemical binding]; other site 229193009333 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 229193009334 Domain of unknown function; Region: EKR; pfam10371 229193009335 4Fe-4S binding domain; Region: Fer4_6; pfam12837 229193009336 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 229193009337 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 229193009338 TPP-binding site [chemical binding]; other site 229193009339 dimer interface [polypeptide binding]; other site 229193009340 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 229193009341 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 229193009342 Ligand Binding Site [chemical binding]; other site 229193009343 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 229193009344 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 229193009345 substrate binding pocket [chemical binding]; other site 229193009346 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 229193009347 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 229193009348 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 229193009349 DNA binding residues [nucleotide binding] 229193009350 dimer interface [polypeptide binding]; other site 229193009351 probable transmembrane helix predicted by TMHMM2.0 229193009352 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 229193009353 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 229193009354 Cl binding site [ion binding]; other site 229193009355 oligomer interface [polypeptide binding]; other site 229193009356 probable transmembrane helix predicted by TMHMM2.0 229193009357 probable transmembrane helix predicted by TMHMM2.0 229193009358 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 229193009359 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 229193009360 peptide binding site [polypeptide binding]; other site 229193009361 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 229193009362 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 229193009363 putative active site [active] 229193009364 Zn binding site [ion binding]; other site 229193009365 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 229193009366 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 229193009367 active site 229193009368 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 229193009369 dimer interface [polypeptide binding]; other site 229193009370 catalytic triad [active] 229193009371 peroxidatic and resolving cysteines [active] 229193009372 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193009373 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 229193009374 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 229193009375 PAS domain; Region: PAS; smart00091 229193009376 putative active site [active] 229193009377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193009378 Walker A motif; other site 229193009379 ATP binding site [chemical binding]; other site 229193009380 Walker B motif; other site 229193009381 arginine finger; other site 229193009382 ProfileScan match to entry PS50116 HTH_FIS_FAMILY, E-value 10.826 229193009383 Uncharacterized conserved protein [Function unknown]; Region: COG5642 229193009384 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 229193009385 Uncharacterized conserved protein [Function unknown]; Region: COG5654 229193009386 hypothetical protein; Provisional; Region: PRK05415 229193009387 Domain of unknown function (DUF697); Region: DUF697; cl12064 229193009388 HMMPfam match to entry PF05128 DUF697, E-value 8.2e-179 229193009389 Predicted ATPase [General function prediction only]; Region: COG3106 229193009390 HMMPfam match to entry PF04317 DUF463, E-value 0 229193009391 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; pfam09584 229193009392 probable transmembrane helix predicted by TMHMM2.0 229193009393 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 229193009394 phage shock protein C; Region: phageshock_pspC; TIGR02978 229193009395 HMMPfam match to entry PF04024 PspC, E-value 2.5e-26 229193009396 probable transmembrane helix predicted by TMHMM2.0 229193009397 phage shock protein B; Provisional; Region: pspB; PRK09458 229193009398 probable transmembrane helix predicted by TMHMM2.0 229193009399 phage shock protein PspA; Provisional; Region: PRK10698 229193009400 HMMPfam match to entry PF04012 PspA_IM30, E-value 1.4e-49 229193009401 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 229193009402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193009403 Walker A motif; other site 229193009404 ATP binding site [chemical binding]; other site 229193009405 Walker B motif; other site 229193009406 arginine finger; other site 229193009407 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 229193009408 ProfileScan match to entry PS50116 HTH_FIS_FAMILY, E-value 12.537 229193009409 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193009410 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 229193009411 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 229193009412 peptide binding site [polypeptide binding]; other site 229193009413 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 229193009414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193009415 dimer interface [polypeptide binding]; other site 229193009416 conserved gate region; other site 229193009417 putative PBP binding loops; other site 229193009418 ABC-ATPase subunit interface; other site 229193009419 probable transmembrane helix predicted by TMHMM2.0 229193009420 probable transmembrane helix predicted by TMHMM2.0 229193009421 probable transmembrane helix predicted by TMHMM2.0 229193009422 probable transmembrane helix predicted by TMHMM2.0 229193009423 probable transmembrane helix predicted by TMHMM2.0 229193009424 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 229193009425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193009426 putative PBP binding loops; other site 229193009427 dimer interface [polypeptide binding]; other site 229193009428 ABC-ATPase subunit interface; other site 229193009429 probable transmembrane helix predicted by TMHMM2.0 229193009430 probable transmembrane helix predicted by TMHMM2.0 229193009431 probable transmembrane helix predicted by TMHMM2.0 229193009432 probable transmembrane helix predicted by TMHMM2.0 229193009433 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 229193009434 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193009435 Walker A/P-loop; other site 229193009436 ATP binding site [chemical binding]; other site 229193009437 Q-loop/lid; other site 229193009438 ABC transporter signature motif; other site 229193009439 Walker B; other site 229193009440 D-loop; other site 229193009441 H-loop/switch region; other site 229193009442 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 229193009443 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 229193009444 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193009445 Walker A/P-loop; other site 229193009446 ATP binding site [chemical binding]; other site 229193009447 Q-loop/lid; other site 229193009448 ABC transporter signature motif; other site 229193009449 Walker B; other site 229193009450 D-loop; other site 229193009451 H-loop/switch region; other site 229193009452 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 229193009453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 229193009454 Uncharacterized conserved protein [Function unknown]; Region: COG2128 229193009455 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 229193009456 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 229193009457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193009458 putative substrate translocation pore; other site 229193009459 POT family; Region: PTR2; pfam00854 229193009460 probable transmembrane helix predicted by TMHMM2.0 229193009461 probable transmembrane helix predicted by TMHMM2.0 229193009462 probable transmembrane helix predicted by TMHMM2.0 229193009463 probable transmembrane helix predicted by TMHMM2.0 229193009464 probable transmembrane helix predicted by TMHMM2.0 229193009465 probable transmembrane helix predicted by TMHMM2.0 229193009466 probable transmembrane helix predicted by TMHMM2.0 229193009467 probable transmembrane helix predicted by TMHMM2.0 229193009468 probable transmembrane helix predicted by TMHMM2.0 229193009469 probable transmembrane helix predicted by TMHMM2.0 229193009470 probable transmembrane helix predicted by TMHMM2.0 229193009471 probable transmembrane helix predicted by TMHMM2.0 229193009472 probable transmembrane helix predicted by TMHMM2.0 229193009473 probable transmembrane helix predicted by TMHMM2.0 229193009474 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 229193009475 probable transmembrane helix predicted by TMHMM2.0 229193009476 probable transmembrane helix predicted by TMHMM2.0 229193009477 probable transmembrane helix predicted by TMHMM2.0 229193009478 probable transmembrane helix predicted by TMHMM2.0 229193009479 probable transmembrane helix predicted by TMHMM2.0 229193009480 hypothetical protein; Provisional; Region: PRK10515 229193009481 glutathionine S-transferase; Provisional; Region: PRK10542 229193009482 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 229193009483 C-terminal domain interface [polypeptide binding]; other site 229193009484 GSH binding site (G-site) [chemical binding]; other site 229193009485 dimer interface [polypeptide binding]; other site 229193009486 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 229193009487 dimer interface [polypeptide binding]; other site 229193009488 N-terminal domain interface [polypeptide binding]; other site 229193009489 substrate binding pocket (H-site) [chemical binding]; other site 229193009490 pyridoxamine kinase; Validated; Region: PRK05756 229193009491 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 229193009492 dimer interface [polypeptide binding]; other site 229193009493 pyridoxal binding site [chemical binding]; other site 229193009494 ATP binding site [chemical binding]; other site 229193009495 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 229193009496 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 229193009497 active site 229193009498 HIGH motif; other site 229193009499 dimer interface [polypeptide binding]; other site 229193009500 KMSKS motif; other site 229193009501 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 229193009502 RNA binding surface [nucleotide binding]; other site 229193009503 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 229193009504 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 229193009505 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 229193009506 Predicted periplasmic protein [General function prediction only]; Region: COG3895 229193009507 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 229193009508 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 229193009509 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 229193009510 ProfileScan match to entry PS50315 GLY_RICH, E-value 8.908 229193009511 transcriptional regulator SlyA; Provisional; Region: PRK03573 229193009512 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 229193009513 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 229193009514 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 229193009515 active site 229193009516 catalytic tetrad [active] 229193009517 Predicted Fe-S protein [General function prediction only]; Region: COG3313 229193009518 putative metal dependent hydrolase; Provisional; Region: PRK11598 229193009519 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 229193009520 Sulfatase; Region: Sulfatase; pfam00884 229193009521 probable transmembrane helix predicted by TMHMM2.0 229193009522 probable transmembrane helix predicted by TMHMM2.0 229193009523 probable transmembrane helix predicted by TMHMM2.0 229193009524 probable transmembrane helix predicted by TMHMM2.0 229193009525 probable transmembrane helix predicted by TMHMM2.0 229193009526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 229193009527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 229193009528 probable transmembrane helix predicted by TMHMM2.0 229193009529 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 229193009530 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 229193009531 FMN binding site [chemical binding]; other site 229193009532 active site 229193009533 substrate binding site [chemical binding]; other site 229193009534 catalytic residue [active] 229193009535 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 229193009536 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 229193009537 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 229193009538 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 229193009539 dimer interface [polypeptide binding]; other site 229193009540 active site 229193009541 metal binding site [ion binding]; metal-binding site 229193009542 glutathione binding site [chemical binding]; other site 229193009543 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 229193009544 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 229193009545 dimer interface [polypeptide binding]; other site 229193009546 catalytic site [active] 229193009547 putative active site [active] 229193009548 putative substrate binding site [chemical binding]; other site 229193009549 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 229193009550 putative GSH binding site [chemical binding]; other site 229193009551 catalytic residues [active] 229193009552 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 229193009553 NlpC/P60 family; Region: NLPC_P60; pfam00877 229193009554 probable transmembrane helix predicted by TMHMM2.0 229193009555 superoxide dismutase; Provisional; Region: PRK10543 229193009556 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 229193009557 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 229193009558 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 229193009559 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193009560 DNA binding site [nucleotide binding] 229193009561 domain linker motif; other site 229193009562 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 229193009563 dimerization interface [polypeptide binding]; other site 229193009564 ligand binding site [chemical binding]; other site 229193009565 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 229193009566 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193009567 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 229193009568 dimerization interface [polypeptide binding]; other site 229193009569 putative transporter; Provisional; Region: PRK11043 229193009570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193009571 putative substrate translocation pore; other site 229193009572 probable transmembrane helix predicted by TMHMM2.0 229193009573 probable transmembrane helix predicted by TMHMM2.0 229193009574 probable transmembrane helix predicted by TMHMM2.0 229193009575 probable transmembrane helix predicted by TMHMM2.0 229193009576 probable transmembrane helix predicted by TMHMM2.0 229193009577 probable transmembrane helix predicted by TMHMM2.0 229193009578 probable transmembrane helix predicted by TMHMM2.0 229193009579 probable transmembrane helix predicted by TMHMM2.0 229193009580 probable transmembrane helix predicted by TMHMM2.0 229193009581 probable transmembrane helix predicted by TMHMM2.0 229193009582 probable transmembrane helix predicted by TMHMM2.0 229193009583 probable transmembrane helix predicted by TMHMM2.0 229193009584 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 229193009585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193009586 S-adenosylmethionine binding site [chemical binding]; other site 229193009587 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 229193009588 Lumazine binding domain; Region: Lum_binding; pfam00677 229193009589 Lumazine binding domain; Region: Lum_binding; pfam00677 229193009590 multidrug efflux protein; Reviewed; Region: PRK01766 229193009591 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 229193009592 cation binding site [ion binding]; other site 229193009593 probable transmembrane helix predicted by TMHMM2.0 229193009594 probable transmembrane helix predicted by TMHMM2.0 229193009595 probable transmembrane helix predicted by TMHMM2.0 229193009596 probable transmembrane helix predicted by TMHMM2.0 229193009597 probable transmembrane helix predicted by TMHMM2.0 229193009598 probable transmembrane helix predicted by TMHMM2.0 229193009599 probable transmembrane helix predicted by TMHMM2.0 229193009600 probable transmembrane helix predicted by TMHMM2.0 229193009601 probable transmembrane helix predicted by TMHMM2.0 229193009602 probable transmembrane helix predicted by TMHMM2.0 229193009603 probable transmembrane helix predicted by TMHMM2.0 229193009604 probable transmembrane helix predicted by TMHMM2.0 229193009605 pyruvate kinase; Provisional; Region: PRK09206 229193009606 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 229193009607 domain interfaces; other site 229193009608 active site 229193009609 murein lipoprotein; Provisional; Region: PRK15396 229193009610 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193009611 highly similar to Yersinia pestis KIM y1940; disrupted by IS100 element 229193009612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193009613 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193009614 DNA-binding interface [nucleotide binding]; DNA binding site 229193009615 Integrase core domain; Region: rve; pfam00665 229193009616 transposase/IS protein; Provisional; Region: PRK09183 229193009617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193009618 Walker A motif; other site 229193009619 ATP binding site [chemical binding]; other site 229193009620 Walker B motif; other site 229193009621 Contains ErfK/YbiS/YcfS/YnhG (Interpro|IPR005490) 229193009622 cysteine desufuration protein SufE; Provisional; Region: PRK09296 229193009623 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 229193009624 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 229193009625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193009626 catalytic residue [active] 229193009627 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 229193009628 FeS assembly protein SufD; Region: sufD; TIGR01981 229193009629 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 229193009630 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 229193009631 Walker A/P-loop; other site 229193009632 ATP binding site [chemical binding]; other site 229193009633 Q-loop/lid; other site 229193009634 ABC transporter signature motif; other site 229193009635 Walker B; other site 229193009636 D-loop; other site 229193009637 H-loop/switch region; other site 229193009638 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 229193009639 putative ABC transporter; Region: ycf24; CHL00085 229193009640 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 229193009641 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 229193009642 CoenzymeA binding site [chemical binding]; other site 229193009643 subunit interaction site [polypeptide binding]; other site 229193009644 PHB binding site; other site 229193009645 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 229193009646 FAD binding domain; Region: FAD_binding_4; pfam01565 229193009647 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 229193009648 putative inner membrane protein; Provisional; Region: PRK10983 229193009649 Domain of unknown function DUF20; Region: UPF0118; pfam01594 229193009650 probable transmembrane helix predicted by TMHMM2.0 229193009651 probable transmembrane helix predicted by TMHMM2.0 229193009652 probable transmembrane helix predicted by TMHMM2.0 229193009653 probable transmembrane helix predicted by TMHMM2.0 229193009654 probable transmembrane helix predicted by TMHMM2.0 229193009655 probable transmembrane helix predicted by TMHMM2.0 229193009656 probable transmembrane helix predicted by TMHMM2.0 229193009657 probable transmembrane helix predicted by TMHMM2.0 229193009658 phosphoenolpyruvate synthase; Validated; Region: PRK06464 229193009659 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 229193009660 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 229193009661 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 229193009662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 229193009663 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 229193009664 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 229193009665 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 229193009666 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 229193009667 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 229193009668 NlpC/P60 family; Region: NLPC_P60; pfam00877 229193009669 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 229193009670 probable transmembrane helix predicted by TMHMM2.0 229193009671 probable transmembrane helix predicted by TMHMM2.0 229193009672 probable transmembrane helix predicted by TMHMM2.0 229193009673 probable transmembrane helix predicted by TMHMM2.0 229193009674 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 229193009675 probable transmembrane helix predicted by TMHMM2.0 229193009676 probable transmembrane helix predicted by TMHMM2.0 229193009677 probable transmembrane helix predicted by TMHMM2.0 229193009678 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 229193009679 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 229193009680 probable transmembrane helix predicted by TMHMM2.0 229193009681 probable transmembrane helix predicted by TMHMM2.0 229193009682 probable transmembrane helix predicted by TMHMM2.0 229193009683 probable transmembrane helix predicted by TMHMM2.0 229193009684 probable transmembrane helix predicted by TMHMM2.0 229193009685 probable transmembrane helix predicted by TMHMM2.0 229193009686 probable transmembrane helix predicted by TMHMM2.0 229193009687 probable transmembrane helix predicted by TMHMM2.0 229193009688 probable transmembrane helix predicted by TMHMM2.0 229193009689 probable transmembrane helix predicted by TMHMM2.0 229193009690 probable transmembrane helix predicted by TMHMM2.0 229193009691 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 229193009692 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 229193009693 putative active site [active] 229193009694 putative catalytic site [active] 229193009695 putative Zn binding site [ion binding]; other site 229193009696 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 229193009697 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 229193009698 active site 229193009699 substrate binding site [chemical binding]; other site 229193009700 cosubstrate binding site; other site 229193009701 catalytic site [active] 229193009702 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 229193009703 active site 229193009704 hexamer interface [polypeptide binding]; other site 229193009705 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 229193009706 NAD binding site [chemical binding]; other site 229193009707 substrate binding site [chemical binding]; other site 229193009708 active site 229193009709 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 229193009710 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 229193009711 Ligand binding site; other site 229193009712 Putative Catalytic site; other site 229193009713 DXD motif; other site 229193009714 probable transmembrane helix predicted by TMHMM2.0 229193009715 probable transmembrane helix predicted by TMHMM2.0 229193009716 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 229193009717 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 229193009718 inhibitor-cofactor binding pocket; inhibition site 229193009719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193009720 catalytic residue [active] 229193009721 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 229193009722 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 229193009723 Walker A/P-loop; other site 229193009724 ATP binding site [chemical binding]; other site 229193009725 Q-loop/lid; other site 229193009726 ABC transporter signature motif; other site 229193009727 Walker B; other site 229193009728 D-loop; other site 229193009729 H-loop/switch region; other site 229193009730 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 229193009731 catalytic residues [active] 229193009732 dimer interface [polypeptide binding]; other site 229193009733 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 229193009734 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193009735 ABC-ATPase subunit interface; other site 229193009736 dimer interface [polypeptide binding]; other site 229193009737 putative PBP binding regions; other site 229193009738 probable transmembrane helix predicted by TMHMM2.0 229193009739 probable transmembrane helix predicted by TMHMM2.0 229193009740 probable transmembrane helix predicted by TMHMM2.0 229193009741 probable transmembrane helix predicted by TMHMM2.0 229193009742 probable transmembrane helix predicted by TMHMM2.0 229193009743 probable transmembrane helix predicted by TMHMM2.0 229193009744 probable transmembrane helix predicted by TMHMM2.0 229193009745 probable transmembrane helix predicted by TMHMM2.0 229193009746 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 229193009747 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 229193009748 IHF dimer interface [polypeptide binding]; other site 229193009749 IHF - DNA interface [nucleotide binding]; other site 229193009750 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 229193009751 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 229193009752 putative tRNA-binding site [nucleotide binding]; other site 229193009753 B3/4 domain; Region: B3_4; pfam03483 229193009754 tRNA synthetase B5 domain; Region: B5; smart00874 229193009755 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 229193009756 dimer interface [polypeptide binding]; other site 229193009757 motif 1; other site 229193009758 motif 3; other site 229193009759 motif 2; other site 229193009760 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 229193009761 ProfileScan match to entry PS50886 TRBD, E-value 37.655 229193009762 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 229193009763 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 229193009764 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 229193009765 dimer interface [polypeptide binding]; other site 229193009766 motif 1; other site 229193009767 active site 229193009768 motif 2; other site 229193009769 motif 3; other site 229193009770 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 229193009771 23S rRNA binding site [nucleotide binding]; other site 229193009772 L21 binding site [polypeptide binding]; other site 229193009773 L13 binding site [polypeptide binding]; other site 229193009774 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 229193009775 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 229193009776 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 229193009777 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 229193009778 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 229193009779 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 229193009780 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 229193009781 active site 229193009782 dimer interface [polypeptide binding]; other site 229193009783 motif 1; other site 229193009784 motif 2; other site 229193009785 motif 3; other site 229193009786 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 229193009787 anticodon binding site; other site 229193009788 probable transmembrane helix predicted by TMHMM2.0 229193009789 KTSC domain; Region: KTSC; pfam13619 229193009790 probable transmembrane helix predicted by TMHMM2.0 229193009791 probable transmembrane helix predicted by TMHMM2.0 229193009792 inner membrane protein; Provisional; Region: PRK10995 229193009793 probable transmembrane helix predicted by TMHMM2.0 229193009794 BlastProDom match to entry PD006289 sp_P31123_MARC_ECOLI, E-value 6e-65 229193009795 probable transmembrane helix predicted by TMHMM2.0 229193009796 probable transmembrane helix predicted by TMHMM2.0 229193009797 probable transmembrane helix predicted by TMHMM2.0 229193009798 probable transmembrane helix predicted by TMHMM2.0 229193009799 probable transmembrane helix predicted by TMHMM2.0 229193009800 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 229193009801 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 229193009802 N-acetyl-D-glucosamine binding site [chemical binding]; other site 229193009803 catalytic residue [active] 229193009804 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 229193009805 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 229193009806 metal binding site [ion binding]; metal-binding site 229193009807 probable transmembrane helix predicted by TMHMM2.0 229193009808 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 229193009809 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 229193009810 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 229193009811 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193009812 ABC-ATPase subunit interface; other site 229193009813 dimer interface [polypeptide binding]; other site 229193009814 putative PBP binding regions; other site 229193009815 probable transmembrane helix predicted by TMHMM2.0 229193009816 probable transmembrane helix predicted by TMHMM2.0 229193009817 probable transmembrane helix predicted by TMHMM2.0 229193009818 probable transmembrane helix predicted by TMHMM2.0 229193009819 probable transmembrane helix predicted by TMHMM2.0 229193009820 probable transmembrane helix predicted by TMHMM2.0 229193009821 probable transmembrane helix predicted by TMHMM2.0 229193009822 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 229193009823 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193009824 ABC-ATPase subunit interface; other site 229193009825 dimer interface [polypeptide binding]; other site 229193009826 putative PBP binding regions; other site 229193009827 probable transmembrane helix predicted by TMHMM2.0 229193009828 probable transmembrane helix predicted by TMHMM2.0 229193009829 probable transmembrane helix predicted by TMHMM2.0 229193009830 probable transmembrane helix predicted by TMHMM2.0 229193009831 probable transmembrane helix predicted by TMHMM2.0 229193009832 probable transmembrane helix predicted by TMHMM2.0 229193009833 probable transmembrane helix predicted by TMHMM2.0 229193009834 probable transmembrane helix predicted by TMHMM2.0 229193009835 Phosphotransferase enzyme family; Region: APH; pfam01636 229193009836 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 229193009837 active site 229193009838 ATP binding site [chemical binding]; other site 229193009839 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 229193009840 YniB-like protein; Region: YniB; pfam14002 229193009841 probable transmembrane helix predicted by TMHMM2.0 229193009842 probable transmembrane helix predicted by TMHMM2.0 229193009843 probable transmembrane helix predicted by TMHMM2.0 229193009844 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 229193009845 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193009846 motif II; other site 229193009847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193009848 MULE transposase domain; Region: MULE; pfam10551 229193009849 probable transmembrane helix predicted by TMHMM2.0 229193009850 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 229193009851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 229193009852 hypothetical protein; Provisional; Region: PRK04940 229193009853 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 229193009854 beta-hexosaminidase; Provisional; Region: PRK05337 229193009855 thiamine kinase; Region: ycfN_thiK; TIGR02721 229193009856 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 229193009857 active site 229193009858 substrate binding site [chemical binding]; other site 229193009859 ATP binding site [chemical binding]; other site 229193009860 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 229193009861 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 229193009862 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 229193009863 putative dimer interface [polypeptide binding]; other site 229193009864 probable transmembrane helix predicted by TMHMM2.0 229193009865 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 229193009866 nucleotide binding site/active site [active] 229193009867 HIT family signature motif; other site 229193009868 catalytic residue [active] 229193009869 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 229193009870 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 229193009871 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 229193009872 shikimate binding site; other site 229193009873 NAD(P) binding site [chemical binding]; other site 229193009874 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193009875 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 229193009876 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 229193009877 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 229193009878 active site turn [active] 229193009879 phosphorylation site [posttranslational modification] 229193009880 probable transmembrane helix predicted by TMHMM2.0 229193009881 probable transmembrane helix predicted by TMHMM2.0 229193009882 probable transmembrane helix predicted by TMHMM2.0 229193009883 probable transmembrane helix predicted by TMHMM2.0 229193009884 probable transmembrane helix predicted by TMHMM2.0 229193009885 probable transmembrane helix predicted by TMHMM2.0 229193009886 probable transmembrane helix predicted by TMHMM2.0 229193009887 probable transmembrane helix predicted by TMHMM2.0 229193009888 probable transmembrane helix predicted by TMHMM2.0 229193009889 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 229193009890 active site 229193009891 DNA polymerase III subunit delta'; Validated; Region: PRK07993 229193009892 DNA polymerase III subunit delta'; Validated; Region: PRK08485 229193009893 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 229193009894 thymidylate kinase; Validated; Region: tmk; PRK00698 229193009895 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 229193009896 TMP-binding site; other site 229193009897 ATP-binding site [chemical binding]; other site 229193009898 BlastProDom match to entry PD002766 sp_O69169_KTHY_YERPE, E-value 3e-55 229193009899 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 229193009900 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 229193009901 dimerization interface [polypeptide binding]; other site 229193009902 probable transmembrane helix predicted by TMHMM2.0 229193009903 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 229193009904 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 229193009905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193009906 catalytic residue [active] 229193009907 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193009908 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 229193009909 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 229193009910 dimer interface [polypeptide binding]; other site 229193009911 active site 229193009912 acyl carrier protein; Provisional; Region: acpP; PRK00982 229193009913 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 229193009914 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 229193009915 NAD(P) binding site [chemical binding]; other site 229193009916 homotetramer interface [polypeptide binding]; other site 229193009917 homodimer interface [polypeptide binding]; other site 229193009918 active site 229193009919 probable transmembrane helix predicted by TMHMM2.0 229193009920 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 229193009921 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 229193009922 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 229193009923 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 229193009924 dimer interface [polypeptide binding]; other site 229193009925 active site 229193009926 CoA binding pocket [chemical binding]; other site 229193009927 Fatty acid/phospholipid biosynthesis enzyme [Lipid metabolism]; Region: PlsX; COG0416 229193009928 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 229193009929 hypothetical protein; Provisional; Region: PRK11193 229193009930 Maf-like protein; Region: Maf; pfam02545 229193009931 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 229193009932 active site 229193009933 dimer interface [polypeptide binding]; other site 229193009934 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 229193009935 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 229193009936 RNA binding surface [nucleotide binding]; other site 229193009937 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 229193009938 active site 229193009939 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 229193009940 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 229193009941 homodimer interface [polypeptide binding]; other site 229193009942 oligonucleotide binding site [chemical binding]; other site 229193009943 ProfileScan match to entry PS50321 ASN_RICH, E-value 9.237 229193009944 ProfileScan match to entry PS50323 ARG_RICH_1, E-value 13.458 229193009945 ProfileScan match to entry PS50323 ARG_RICH_1, E-value 9.153 229193009946 ProfileScan match to entry PS50326 VAL_RICH, E-value 10.495 229193009947 ProfileScan match to entry PS50310 ALA_RICH, E-value 8.657 229193009948 Uncharacterized conserved protein [Function unknown]; Region: COG1359 229193009949 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 229193009950 active site 229193009951 substrate binding pocket [chemical binding]; other site 229193009952 dimer interface [polypeptide binding]; other site 229193009953 DNA damage-inducible protein I; Provisional; Region: PRK10597 229193009954 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193009955 MULE transposase domain; Region: MULE; pfam10551 229193009956 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 229193009957 hydroxyglutarate oxidase; Provisional; Region: PRK11728 229193009958 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 229193009959 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193009960 DNA binding residues [nucleotide binding] 229193009961 dimerization interface [polypeptide binding]; other site 229193009962 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 229193009963 Domain of unknown function DUF20; Region: UPF0118; pfam01594 229193009964 probable transmembrane helix predicted by TMHMM2.0 229193009965 probable transmembrane helix predicted by TMHMM2.0 229193009966 probable transmembrane helix predicted by TMHMM2.0 229193009967 probable transmembrane helix predicted by TMHMM2.0 229193009968 probable transmembrane helix predicted by TMHMM2.0 229193009969 probable transmembrane helix predicted by TMHMM2.0 229193009970 probable transmembrane helix predicted by TMHMM2.0 229193009971 probable transmembrane helix predicted by TMHMM2.0 229193009972 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 229193009973 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 229193009974 active site residue [active] 229193009975 ProfileScan match to entry PS50311 CYS_RICH, E-value 9.433 229193009976 probable transmembrane helix predicted by TMHMM2.0 229193009977 probable transmembrane helix predicted by TMHMM2.0 229193009978 EamA-like transporter family; Region: EamA; pfam00892 229193009979 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 229193009980 probable transmembrane helix predicted by TMHMM2.0 229193009981 probable transmembrane helix predicted by TMHMM2.0 229193009982 probable transmembrane helix predicted by TMHMM2.0 229193009983 probable transmembrane helix predicted by TMHMM2.0 229193009984 probable transmembrane helix predicted by TMHMM2.0 229193009985 probable transmembrane helix predicted by TMHMM2.0 229193009986 probable transmembrane helix predicted by TMHMM2.0 229193009987 Autoinducer synthetase; Region: Autoind_synth; pfam00765 229193009988 Autoinducer binding domain; Region: Autoind_bind; pfam03472 229193009989 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193009990 DNA binding residues [nucleotide binding] 229193009991 dimerization interface [polypeptide binding]; other site 229193009992 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 229193009993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193009994 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 229193009995 dimerization interface [polypeptide binding]; other site 229193009996 benzoate transport; Region: 2A0115; TIGR00895 229193009997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193009998 putative substrate translocation pore; other site 229193009999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193010000 probable transmembrane helix predicted by TMHMM2.0 229193010001 probable transmembrane helix predicted by TMHMM2.0 229193010002 probable transmembrane helix predicted by TMHMM2.0 229193010003 probable transmembrane helix predicted by TMHMM2.0 229193010004 probable transmembrane helix predicted by TMHMM2.0 229193010005 probable transmembrane helix predicted by TMHMM2.0 229193010006 probable transmembrane helix predicted by TMHMM2.0 229193010007 probable transmembrane helix predicted by TMHMM2.0 229193010008 probable transmembrane helix predicted by TMHMM2.0 229193010009 probable transmembrane helix predicted by TMHMM2.0 229193010010 probable transmembrane helix predicted by TMHMM2.0 229193010011 probable transmembrane helix predicted by TMHMM2.0 229193010012 Formaldehyde-activating enzyme nesessary for methanogenesis [Energy production and conversion]; Region: COG1795 229193010013 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 229193010014 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 229193010015 active site 229193010016 catalytic tetrad [active] 229193010017 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09674 229193010018 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 229193010019 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09676 229193010020 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09675 229193010021 probable transmembrane helix predicted by TMHMM2.0 229193010022 probable transmembrane helix predicted by TMHMM2.0 229193010023 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 229193010024 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 229193010025 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 229193010026 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 229193010027 Mechanosensitive ion channel; Region: MS_channel; pfam00924 229193010028 probable transmembrane helix predicted by TMHMM2.0 229193010029 probable transmembrane helix predicted by TMHMM2.0 229193010030 probable transmembrane helix predicted by TMHMM2.0 229193010031 probable transmembrane helix predicted by TMHMM2.0 229193010032 probable transmembrane helix predicted by TMHMM2.0 229193010033 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 229193010034 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 229193010035 active site 229193010036 HMMPfam match to entry PF04041 DUF377, E-value 7.5e-42 229193010037 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 229193010038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193010039 dimer interface [polypeptide binding]; other site 229193010040 conserved gate region; other site 229193010041 putative PBP binding loops; other site 229193010042 ABC-ATPase subunit interface; other site 229193010043 probable transmembrane helix predicted by TMHMM2.0 229193010044 probable transmembrane helix predicted by TMHMM2.0 229193010045 probable transmembrane helix predicted by TMHMM2.0 229193010046 probable transmembrane helix predicted by TMHMM2.0 229193010047 probable transmembrane helix predicted by TMHMM2.0 229193010048 probable transmembrane helix predicted by TMHMM2.0 229193010049 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 229193010050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193010051 dimer interface [polypeptide binding]; other site 229193010052 putative PBP binding loops; other site 229193010053 ABC-ATPase subunit interface; other site 229193010054 probable transmembrane helix predicted by TMHMM2.0 229193010055 probable transmembrane helix predicted by TMHMM2.0 229193010056 probable transmembrane helix predicted by TMHMM2.0 229193010057 probable transmembrane helix predicted by TMHMM2.0 229193010058 probable transmembrane helix predicted by TMHMM2.0 229193010059 probable transmembrane helix predicted by TMHMM2.0 229193010060 probable transmembrane helix predicted by TMHMM2.0 229193010061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 229193010062 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 229193010063 probable transmembrane helix predicted by TMHMM2.0 229193010064 Transcriptional regulators [Transcription]; Region: PurR; COG1609 229193010065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193010066 DNA binding site [nucleotide binding] 229193010067 domain linker motif; other site 229193010068 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 229193010069 putative dimerization interface [polypeptide binding]; other site 229193010070 putative ligand binding site [chemical binding]; other site 229193010071 phosphomannomutase CpsG; Provisional; Region: PRK15414 229193010072 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 229193010073 active site 229193010074 substrate binding site [chemical binding]; other site 229193010075 metal binding site [ion binding]; metal-binding site 229193010076 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 229193010077 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 229193010078 Walker A/P-loop; other site 229193010079 ATP binding site [chemical binding]; other site 229193010080 Q-loop/lid; other site 229193010081 ABC transporter signature motif; other site 229193010082 Walker B; other site 229193010083 D-loop; other site 229193010084 H-loop/switch region; other site 229193010085 TOBE domain; Region: TOBE_2; pfam08402 229193010086 BlastProDom match to entry PD039360 sp_O27709_O27709_METTH, E-value 5e-07 229193010087 probable transmembrane helix predicted by TMHMM2.0 229193010088 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 229193010089 probable transmembrane helix predicted by TMHMM2.0 229193010090 haemagglutination activity domain; Region: Haemagg_act; pfam05860 229193010091 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 229193010092 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 229193010093 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 229193010094 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 229193010095 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 229193010096 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 229193010097 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 229193010098 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 229193010099 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 229193010100 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 229193010101 FMN-binding pocket [chemical binding]; other site 229193010102 flavin binding motif; other site 229193010103 phosphate binding motif [ion binding]; other site 229193010104 beta-alpha-beta structure motif; other site 229193010105 NAD binding pocket [chemical binding]; other site 229193010106 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 229193010107 catalytic loop [active] 229193010108 iron binding site [ion binding]; other site 229193010109 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 229193010110 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 229193010111 [2Fe-2S] cluster binding site [ion binding]; other site 229193010112 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 229193010113 putative alpha subunit interface [polypeptide binding]; other site 229193010114 putative active site [active] 229193010115 putative substrate binding site [chemical binding]; other site 229193010116 Fe binding site [ion binding]; other site 229193010117 putative transporter; Provisional; Region: PRK09950 229193010118 probable transmembrane helix predicted by TMHMM2.0 229193010119 probable transmembrane helix predicted by TMHMM2.0 229193010120 probable transmembrane helix predicted by TMHMM2.0 229193010121 probable transmembrane helix predicted by TMHMM2.0 229193010122 probable transmembrane helix predicted by TMHMM2.0 229193010123 probable transmembrane helix predicted by TMHMM2.0 229193010124 probable transmembrane helix predicted by TMHMM2.0 229193010125 probable transmembrane helix predicted by TMHMM2.0 229193010126 probable transmembrane helix predicted by TMHMM2.0 229193010127 probable transmembrane helix predicted by TMHMM2.0 229193010128 probable transmembrane helix predicted by TMHMM2.0 229193010129 probable transmembrane helix predicted by TMHMM2.0 229193010130 Yersinia protein of unknown function (DUF3831); Region: DUF3831; pfam12908 229193010131 probable transmembrane helix predicted by TMHMM2.0 229193010132 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 229193010133 tartrate dehydrogenase; Region: TTC; TIGR02089 229193010134 transcriptional activator TtdR; Provisional; Region: PRK09801 229193010135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193010136 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 229193010137 putative effector binding pocket; other site 229193010138 putative dimerization interface [polypeptide binding]; other site 229193010139 Transcriptional regulators [Transcription]; Region: PurR; COG1609 229193010140 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193010141 DNA binding site [nucleotide binding] 229193010142 domain linker motif; other site 229193010143 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 229193010144 dimerization interface [polypeptide binding]; other site 229193010145 ligand binding site [chemical binding]; other site 229193010146 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193010147 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193010148 TM-ABC transporter signature motif; other site 229193010149 probable transmembrane helix predicted by TMHMM2.0 229193010150 probable transmembrane helix predicted by TMHMM2.0 229193010151 probable transmembrane helix predicted by TMHMM2.0 229193010152 probable transmembrane helix predicted by TMHMM2.0 229193010153 probable transmembrane helix predicted by TMHMM2.0 229193010154 probable transmembrane helix predicted by TMHMM2.0 229193010155 probable transmembrane helix predicted by TMHMM2.0 229193010156 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 229193010157 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193010158 Walker A/P-loop; other site 229193010159 ATP binding site [chemical binding]; other site 229193010160 Q-loop/lid; other site 229193010161 ABC transporter signature motif; other site 229193010162 Walker B; other site 229193010163 D-loop; other site 229193010164 H-loop/switch region; other site 229193010165 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193010166 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 229193010167 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 229193010168 putative ligand binding site [chemical binding]; other site 229193010169 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 229193010170 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 229193010171 putative NAD(P) binding site [chemical binding]; other site 229193010172 catalytic Zn binding site [ion binding]; other site 229193010173 structural Zn binding site [ion binding]; other site 229193010174 probable transmembrane helix predicted by TMHMM2.0 229193010175 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 229193010176 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: COG3965 229193010177 probable transmembrane helix predicted by TMHMM2.0 229193010178 probable transmembrane helix predicted by TMHMM2.0 229193010179 probable transmembrane helix predicted by TMHMM2.0 229193010180 probable transmembrane helix predicted by TMHMM2.0 229193010181 probable transmembrane helix predicted by TMHMM2.0 229193010182 probable transmembrane helix predicted by TMHMM2.0 229193010183 outer membrane protein X; Provisional; Region: ompX; PRK09408 229193010184 probable transmembrane helix predicted by TMHMM2.0 229193010185 threonine and homoserine efflux system; Provisional; Region: PRK10532 229193010186 probable transmembrane helix predicted by TMHMM2.0 229193010187 probable transmembrane helix predicted by TMHMM2.0 229193010188 probable transmembrane helix predicted by TMHMM2.0 229193010189 probable transmembrane helix predicted by TMHMM2.0 229193010190 probable transmembrane helix predicted by TMHMM2.0 229193010191 probable transmembrane helix predicted by TMHMM2.0 229193010192 probable transmembrane helix predicted by TMHMM2.0 229193010193 probable transmembrane helix predicted by TMHMM2.0 229193010194 probable transmembrane helix predicted by TMHMM2.0 229193010195 probable transmembrane helix predicted by TMHMM2.0 229193010196 putative acetyltransferase YhhY; Provisional; Region: PRK10140 229193010197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 229193010198 Coenzyme A binding pocket [chemical binding]; other site 229193010199 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 229193010200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193010201 S-adenosylmethionine binding site [chemical binding]; other site 229193010202 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 229193010203 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 229193010204 dimerization interface [polypeptide binding]; other site 229193010205 DPS ferroxidase diiron center [ion binding]; other site 229193010206 ion pore; other site 229193010207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 229193010208 TPR motif; other site 229193010209 binding surface 229193010210 Uncharacterized conserved protein [Function unknown]; Region: COG1434 229193010211 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 229193010212 putative active site [active] 229193010213 probable transmembrane helix predicted by TMHMM2.0 229193010214 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 229193010215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193010216 substrate binding pocket [chemical binding]; other site 229193010217 membrane-bound complex binding site; other site 229193010218 hinge residues; other site 229193010219 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 229193010220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193010221 dimer interface [polypeptide binding]; other site 229193010222 conserved gate region; other site 229193010223 putative PBP binding loops; other site 229193010224 ABC-ATPase subunit interface; other site 229193010225 probable transmembrane helix predicted by TMHMM2.0 229193010226 probable transmembrane helix predicted by TMHMM2.0 229193010227 probable transmembrane helix predicted by TMHMM2.0 229193010228 probable transmembrane helix predicted by TMHMM2.0 229193010229 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 229193010230 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 229193010231 Walker A/P-loop; other site 229193010232 ATP binding site [chemical binding]; other site 229193010233 Q-loop/lid; other site 229193010234 ABC transporter signature motif; other site 229193010235 Walker B; other site 229193010236 D-loop; other site 229193010237 H-loop/switch region; other site 229193010238 BlastProDom match to entry PD039360 sp_Q57585_Y121_METJA, E-value 2e-07 229193010239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 229193010240 PAS domain; Region: PAS_9; pfam13426 229193010241 putative active site [active] 229193010242 heme pocket [chemical binding]; other site 229193010243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 229193010244 PAS domain; Region: PAS_9; pfam13426 229193010245 putative active site [active] 229193010246 heme pocket [chemical binding]; other site 229193010247 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 229193010248 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 229193010249 dimer interface [polypeptide binding]; other site 229193010250 putative CheW interface [polypeptide binding]; other site 229193010251 BlastProDom match to entry PD000571 sp_O29217_O29217_ARCFU, E-value 7e-15 229193010252 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 229193010253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193010254 S-adenosylmethionine binding site [chemical binding]; other site 229193010255 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 229193010256 probable transmembrane helix predicted by TMHMM2.0 229193010257 glycosyl transferase family protein; Provisional; Region: PRK08136 229193010258 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 229193010259 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 229193010260 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 229193010261 acyl-activating enzyme (AAE) consensus motif; other site 229193010262 putative AMP binding site [chemical binding]; other site 229193010263 putative active site [active] 229193010264 putative CoA binding site [chemical binding]; other site 229193010265 O-succinylbenzoate synthase; Provisional; Region: PRK05105 229193010266 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 229193010267 active site 229193010268 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 229193010269 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 229193010270 substrate binding site [chemical binding]; other site 229193010271 oxyanion hole (OAH) forming residues; other site 229193010272 trimer interface [polypeptide binding]; other site 229193010273 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 229193010274 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 229193010275 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 229193010276 dimer interface [polypeptide binding]; other site 229193010277 tetramer interface [polypeptide binding]; other site 229193010278 PYR/PP interface [polypeptide binding]; other site 229193010279 TPP binding site [chemical binding]; other site 229193010280 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 229193010281 TPP-binding site; other site 229193010282 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 229193010283 chorismate binding enzyme; Region: Chorismate_bind; cl10555 229193010284 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 229193010285 phosphogluconate dehydratase; Validated; Region: PRK09054 229193010286 6-phosphogluconate dehydratase; Region: edd; TIGR01196 229193010287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193010288 D-galactonate transporter; Region: 2A0114; TIGR00893 229193010289 putative substrate translocation pore; other site 229193010290 probable transmembrane helix predicted by TMHMM2.0 229193010291 probable transmembrane helix predicted by TMHMM2.0 229193010292 probable transmembrane helix predicted by TMHMM2.0 229193010293 probable transmembrane helix predicted by TMHMM2.0 229193010294 probable transmembrane helix predicted by TMHMM2.0 229193010295 probable transmembrane helix predicted by TMHMM2.0 229193010296 probable transmembrane helix predicted by TMHMM2.0 229193010297 probable transmembrane helix predicted by TMHMM2.0 229193010298 probable transmembrane helix predicted by TMHMM2.0 229193010299 probable transmembrane helix predicted by TMHMM2.0 229193010300 probable transmembrane helix predicted by TMHMM2.0 229193010301 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 229193010302 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 229193010303 putative ligand binding site [chemical binding]; other site 229193010304 NAD binding site [chemical binding]; other site 229193010305 catalytic site [active] 229193010306 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 229193010307 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193010308 DNA binding site [nucleotide binding] 229193010309 domain linker motif; other site 229193010310 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 229193010311 putative ligand binding site [chemical binding]; other site 229193010312 putative dimerization interface [polypeptide binding]; other site 229193010313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 229193010314 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 229193010315 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 229193010316 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 229193010317 NADP binding site [chemical binding]; other site 229193010318 homodimer interface [polypeptide binding]; other site 229193010319 active site 229193010320 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 229193010321 AAA domain; Region: AAA_33; pfam13671 229193010322 ATP-binding site [chemical binding]; other site 229193010323 Gluconate-6-phosphate binding site [chemical binding]; other site 229193010324 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 229193010325 RNA polymerase I-specific transcription-initiation factor; Region: Rrn6; pfam10214 229193010326 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 229193010327 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 229193010328 probable transmembrane helix predicted by TMHMM2.0 229193010329 probable transmembrane helix predicted by TMHMM2.0 229193010330 probable transmembrane helix predicted by TMHMM2.0 229193010331 probable transmembrane helix predicted by TMHMM2.0 229193010332 probable transmembrane helix predicted by TMHMM2.0 229193010333 probable transmembrane helix predicted by TMHMM2.0 229193010334 probable transmembrane helix predicted by TMHMM2.0 229193010335 probable transmembrane helix predicted by TMHMM2.0 229193010336 probable transmembrane helix predicted by TMHMM2.0 229193010337 probable transmembrane helix predicted by TMHMM2.0 229193010338 probable transmembrane helix predicted by TMHMM2.0 229193010339 probable transmembrane helix predicted by TMHMM2.0 229193010340 probable transmembrane helix predicted by TMHMM2.0 229193010341 probable transmembrane helix predicted by TMHMM2.0 229193010342 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 229193010343 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 229193010344 probable transmembrane helix predicted by TMHMM2.0 229193010345 probable transmembrane helix predicted by TMHMM2.0 229193010346 probable transmembrane helix predicted by TMHMM2.0 229193010347 probable transmembrane helix predicted by TMHMM2.0 229193010348 probable transmembrane helix predicted by TMHMM2.0 229193010349 probable transmembrane helix predicted by TMHMM2.0 229193010350 probable transmembrane helix predicted by TMHMM2.0 229193010351 probable transmembrane helix predicted by TMHMM2.0 229193010352 probable transmembrane helix predicted by TMHMM2.0 229193010353 probable transmembrane helix predicted by TMHMM2.0 229193010354 probable transmembrane helix predicted by TMHMM2.0 229193010355 probable transmembrane helix predicted by TMHMM2.0 229193010356 probable transmembrane helix predicted by TMHMM2.0 229193010357 probable transmembrane helix predicted by TMHMM2.0 229193010358 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 229193010359 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 229193010360 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 229193010361 probable transmembrane helix predicted by TMHMM2.0 229193010362 probable transmembrane helix predicted by TMHMM2.0 229193010363 probable transmembrane helix predicted by TMHMM2.0 229193010364 probable transmembrane helix predicted by TMHMM2.0 229193010365 probable transmembrane helix predicted by TMHMM2.0 229193010366 probable transmembrane helix predicted by TMHMM2.0 229193010367 probable transmembrane helix predicted by TMHMM2.0 229193010368 probable transmembrane helix predicted by TMHMM2.0 229193010369 probable transmembrane helix predicted by TMHMM2.0 229193010370 probable transmembrane helix predicted by TMHMM2.0 229193010371 probable transmembrane helix predicted by TMHMM2.0 229193010372 probable transmembrane helix predicted by TMHMM2.0 229193010373 probable transmembrane helix predicted by TMHMM2.0 229193010374 probable transmembrane helix predicted by TMHMM2.0 229193010375 probable transmembrane helix predicted by TMHMM2.0 229193010376 probable transmembrane helix predicted by TMHMM2.0 229193010377 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 229193010378 probable transmembrane helix predicted by TMHMM2.0 229193010379 probable transmembrane helix predicted by TMHMM2.0 229193010380 probable transmembrane helix predicted by TMHMM2.0 229193010381 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 229193010382 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 229193010383 probable transmembrane helix predicted by TMHMM2.0 229193010384 probable transmembrane helix predicted by TMHMM2.0 229193010385 probable transmembrane helix predicted by TMHMM2.0 229193010386 probable transmembrane helix predicted by TMHMM2.0 229193010387 probable transmembrane helix predicted by TMHMM2.0 229193010388 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 229193010389 4Fe-4S binding domain; Region: Fer4; pfam00037 229193010390 4Fe-4S binding domain; Region: Fer4; pfam00037 229193010391 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 229193010392 probable transmembrane helix predicted by TMHMM2.0 229193010393 probable transmembrane helix predicted by TMHMM2.0 229193010394 probable transmembrane helix predicted by TMHMM2.0 229193010395 probable transmembrane helix predicted by TMHMM2.0 229193010396 probable transmembrane helix predicted by TMHMM2.0 229193010397 probable transmembrane helix predicted by TMHMM2.0 229193010398 probable transmembrane helix predicted by TMHMM2.0 229193010399 probable transmembrane helix predicted by TMHMM2.0 229193010400 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 229193010401 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 229193010402 catalytic loop [active] 229193010403 iron binding site [ion binding]; other site 229193010404 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 229193010405 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 229193010406 [4Fe-4S] binding site [ion binding]; other site 229193010407 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 229193010408 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 229193010409 SLBB domain; Region: SLBB; pfam10531 229193010410 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 229193010411 NADH dehydrogenase subunit E; Validated; Region: PRK07539 229193010412 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 229193010413 putative dimer interface [polypeptide binding]; other site 229193010414 [2Fe-2S] cluster binding site [ion binding]; other site 229193010415 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 229193010416 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 229193010417 NADH dehydrogenase subunit D; Validated; Region: PRK06075 229193010418 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 229193010419 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 229193010420 probable transmembrane helix predicted by TMHMM2.0 229193010421 probable transmembrane helix predicted by TMHMM2.0 229193010422 probable transmembrane helix predicted by TMHMM2.0 229193010423 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 229193010424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193010425 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 229193010426 putative dimerization interface [polypeptide binding]; other site 229193010427 aminotransferase AlaT; Validated; Region: PRK09265 229193010428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 229193010429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193010430 homodimer interface [polypeptide binding]; other site 229193010431 catalytic residue [active] 229193010432 5'-nucleotidase; Provisional; Region: PRK03826 229193010433 probable transmembrane helix predicted by TMHMM2.0 229193010434 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 229193010435 transmembrane helices; other site 229193010436 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 229193010437 TrkA-C domain; Region: TrkA_C; pfam02080 229193010438 TrkA-C domain; Region: TrkA_C; pfam02080 229193010439 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 229193010440 probable transmembrane helix predicted by TMHMM2.0 229193010441 probable transmembrane helix predicted by TMHMM2.0 229193010442 probable transmembrane helix predicted by TMHMM2.0 229193010443 probable transmembrane helix predicted by TMHMM2.0 229193010444 probable transmembrane helix predicted by TMHMM2.0 229193010445 probable transmembrane helix predicted by TMHMM2.0 229193010446 probable transmembrane helix predicted by TMHMM2.0 229193010447 probable transmembrane helix predicted by TMHMM2.0 229193010448 probable transmembrane helix predicted by TMHMM2.0 229193010449 probable transmembrane helix predicted by TMHMM2.0 229193010450 putative phosphatase; Provisional; Region: PRK11587 229193010451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193010452 motif II; other site 229193010453 hypothetical protein; Validated; Region: PRK05445 229193010454 hypothetical protein; Provisional; Region: PRK01816 229193010455 HMMPfam match to entry PF04217 DUF412, E-value 1.5e-82 229193010456 probable transmembrane helix predicted by TMHMM2.0 229193010457 probable transmembrane helix predicted by TMHMM2.0 229193010458 propionate/acetate kinase; Provisional; Region: PRK12379 229193010459 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 229193010460 phosphate acetyltransferase; Reviewed; Region: PRK05632 229193010461 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 229193010462 DRTGG domain; Region: DRTGG; pfam07085 229193010463 phosphate acetyltransferase; Region: pta; TIGR00651 229193010464 Transcriptional regulators [Transcription]; Region: PurR; COG1609 229193010465 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193010466 DNA binding site [nucleotide binding] 229193010467 domain linker motif; other site 229193010468 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 229193010469 putative dimerization interface [polypeptide binding]; other site 229193010470 putative ligand binding site [chemical binding]; other site 229193010471 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 229193010472 active site 229193010473 phosphorylation site [posttranslational modification] 229193010474 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 229193010475 active site 229193010476 P-loop; other site 229193010477 phosphorylation site [posttranslational modification] 229193010478 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 229193010479 HMMPfam match to entry PF04215 SgaT_UlaA, E-value 3.6e-124 229193010480 probable transmembrane helix predicted by TMHMM2.0 229193010481 probable transmembrane helix predicted by TMHMM2.0 229193010482 probable transmembrane helix predicted by TMHMM2.0 229193010483 probable transmembrane helix predicted by TMHMM2.0 229193010484 probable transmembrane helix predicted by TMHMM2.0 229193010485 probable transmembrane helix predicted by TMHMM2.0 229193010486 probable transmembrane helix predicted by TMHMM2.0 229193010487 probable transmembrane helix predicted by TMHMM2.0 229193010488 probable transmembrane helix predicted by TMHMM2.0 229193010489 probable transmembrane helix predicted by TMHMM2.0 229193010490 probable transmembrane helix predicted by TMHMM2.0 229193010491 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 229193010492 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 229193010493 nudix motif; other site 229193010494 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 229193010495 active site 229193010496 metal binding site [ion binding]; metal-binding site 229193010497 homotetramer interface [polypeptide binding]; other site 229193010498 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 229193010499 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 229193010500 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 229193010501 putative NAD(P) binding site [chemical binding]; other site 229193010502 putative active site [active] 229193010503 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 229193010504 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 229193010505 Walker A/P-loop; other site 229193010506 ATP binding site [chemical binding]; other site 229193010507 Q-loop/lid; other site 229193010508 ABC transporter signature motif; other site 229193010509 Walker B; other site 229193010510 D-loop; other site 229193010511 H-loop/switch region; other site 229193010512 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 229193010513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193010514 dimer interface [polypeptide binding]; other site 229193010515 conserved gate region; other site 229193010516 putative PBP binding loops; other site 229193010517 ABC-ATPase subunit interface; other site 229193010518 probable transmembrane helix predicted by TMHMM2.0 229193010519 probable transmembrane helix predicted by TMHMM2.0 229193010520 probable transmembrane helix predicted by TMHMM2.0 229193010521 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 229193010522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193010523 dimer interface [polypeptide binding]; other site 229193010524 conserved gate region; other site 229193010525 putative PBP binding loops; other site 229193010526 ABC-ATPase subunit interface; other site 229193010527 probable transmembrane helix predicted by TMHMM2.0 229193010528 probable transmembrane helix predicted by TMHMM2.0 229193010529 probable transmembrane helix predicted by TMHMM2.0 229193010530 probable transmembrane helix predicted by TMHMM2.0 229193010531 probable transmembrane helix predicted by TMHMM2.0 229193010532 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 229193010533 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193010534 substrate binding pocket [chemical binding]; other site 229193010535 membrane-bound complex binding site; other site 229193010536 hinge residues; other site 229193010537 probable transmembrane helix predicted by TMHMM2.0 229193010538 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 229193010539 Flavoprotein; Region: Flavoprotein; pfam02441 229193010540 amidophosphoribosyltransferase; Provisional; Region: PRK09246 229193010541 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 229193010542 active site 229193010543 tetramer interface [polypeptide binding]; other site 229193010544 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 229193010545 active site 229193010546 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 229193010547 colicin V production protein; Provisional; Region: PRK10845 229193010548 probable transmembrane helix predicted by TMHMM2.0 229193010549 probable transmembrane helix predicted by TMHMM2.0 229193010550 probable transmembrane helix predicted by TMHMM2.0 229193010551 probable transmembrane helix predicted by TMHMM2.0 229193010552 cell division protein DedD; Provisional; Region: PRK11633 229193010553 Sporulation related domain; Region: SPOR; pfam05036 229193010554 HMMPfam match to entry PF05036 SPOR, E-value 6.1 229193010555 HMMPfam match to entry PF05036 SPOR, E-value 0.18 229193010556 probable transmembrane helix predicted by TMHMM2.0 229193010557 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 229193010558 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 229193010559 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 229193010560 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 229193010561 hypothetical protein; Provisional; Region: PRK10847 229193010562 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 229193010563 probable transmembrane helix predicted by TMHMM2.0 229193010564 probable transmembrane helix predicted by TMHMM2.0 229193010565 probable transmembrane helix predicted by TMHMM2.0 229193010566 probable transmembrane helix predicted by TMHMM2.0 229193010567 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 229193010568 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 229193010569 dimerization interface 3.5A [polypeptide binding]; other site 229193010570 active site 229193010571 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 229193010572 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 229193010573 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 229193010574 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 229193010575 ligand binding site [chemical binding]; other site 229193010576 NAD binding site [chemical binding]; other site 229193010577 catalytic site [active] 229193010578 homodimer interface [polypeptide binding]; other site 229193010579 Cupin domain; Region: Cupin_2; pfam07883 229193010580 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 229193010581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193010582 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 229193010583 EamA-like transporter family; Region: EamA; pfam00892 229193010584 probable transmembrane helix predicted by TMHMM2.0 229193010585 probable transmembrane helix predicted by TMHMM2.0 229193010586 probable transmembrane helix predicted by TMHMM2.0 229193010587 probable transmembrane helix predicted by TMHMM2.0 229193010588 probable transmembrane helix predicted by TMHMM2.0 229193010589 probable transmembrane helix predicted by TMHMM2.0 229193010590 probable transmembrane helix predicted by TMHMM2.0 229193010591 probable transmembrane helix predicted by TMHMM2.0 229193010592 probable transmembrane helix predicted by TMHMM2.0 229193010593 probable transmembrane helix predicted by TMHMM2.0 229193010594 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 229193010595 ProfileScan match to entry PS50322 GLN_RICH, E-value 9.781 229193010596 probable transmembrane helix predicted by TMHMM2.0 229193010597 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 229193010598 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 229193010599 aspartate racemase; Region: asp_race; TIGR00035 229193010600 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 229193010601 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 229193010602 dimer interface [polypeptide binding]; other site 229193010603 active site 229193010604 Uncharacterized conserved protein [Function unknown]; Region: COG4121 229193010605 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 229193010606 hydroxyglutarate oxidase; Provisional; Region: PRK11728 229193010607 YfcL protein; Region: YfcL; pfam08891 229193010608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 229193010609 HMMPfam match to entry PF04315 DUF462, E-value 3.9e-123 229193010610 hypothetical protein; Provisional; Region: PRK10621 229193010611 Predicted permeases [General function prediction only]; Region: COG0730 229193010612 probable transmembrane helix predicted by TMHMM2.0 229193010613 probable transmembrane helix predicted by TMHMM2.0 229193010614 probable transmembrane helix predicted by TMHMM2.0 229193010615 probable transmembrane helix predicted by TMHMM2.0 229193010616 probable transmembrane helix predicted by TMHMM2.0 229193010617 probable transmembrane helix predicted by TMHMM2.0 229193010618 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 229193010619 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 229193010620 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 229193010621 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 229193010622 Tetramer interface [polypeptide binding]; other site 229193010623 active site 229193010624 FMN-binding site [chemical binding]; other site 229193010625 HemK family putative methylases; Region: hemK_fam; TIGR00536 229193010626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193010627 S-adenosylmethionine binding site [chemical binding]; other site 229193010628 hypothetical protein; Provisional; Region: PRK04946 229193010629 Smr domain; Region: Smr; pfam01713 229193010630 BlastProDom match to entry PD034991 sp_P77458_YFCN_ECOLI, E-value 5e-66 229193010631 probable transmembrane helix predicted by TMHMM2.0 229193010632 probable transmembrane helix predicted by TMHMM2.0 229193010633 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 229193010634 catalytic core [active] 229193010635 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 229193010636 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 229193010637 substrate binding site [chemical binding]; other site 229193010638 oxyanion hole (OAH) forming residues; other site 229193010639 trimer interface [polypeptide binding]; other site 229193010640 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 229193010641 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 229193010642 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 229193010643 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 229193010644 dimer interface [polypeptide binding]; other site 229193010645 active site 229193010646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 229193010647 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 229193010648 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 229193010649 HMMPfam match to entry PF04333 VacJ, E-value 1.9e-109 229193010650 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 229193010651 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 229193010652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 229193010653 binding surface 229193010654 TPR motif; other site 229193010655 probable transmembrane helix predicted by TMHMM2.0 229193010656 probable transmembrane helix predicted by TMHMM2.0 229193010657 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 229193010658 probable transmembrane helix predicted by TMHMM2.0 229193010659 probable transmembrane helix predicted by TMHMM2.0 229193010660 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 229193010661 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 229193010662 catalytic residues [active] 229193010663 central insert; other site 229193010664 probable transmembrane helix predicted by TMHMM2.0 229193010665 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 229193010666 probable transmembrane helix predicted by TMHMM2.0 229193010667 probable transmembrane helix predicted by TMHMM2.0 229193010668 probable transmembrane helix predicted by TMHMM2.0 229193010669 probable transmembrane helix predicted by TMHMM2.0 229193010670 probable transmembrane helix predicted by TMHMM2.0 229193010671 probable transmembrane helix predicted by TMHMM2.0 229193010672 probable transmembrane helix predicted by TMHMM2.0 229193010673 probable transmembrane helix predicted by TMHMM2.0 229193010674 probable transmembrane helix predicted by TMHMM2.0 229193010675 probable transmembrane helix predicted by TMHMM2.0 229193010676 probable transmembrane helix predicted by TMHMM2.0 229193010677 probable transmembrane helix predicted by TMHMM2.0 229193010678 probable transmembrane helix predicted by TMHMM2.0 229193010679 probable transmembrane helix predicted by TMHMM2.0 229193010680 probable transmembrane helix predicted by TMHMM2.0 229193010681 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 229193010682 probable transmembrane helix predicted by TMHMM2.0 229193010683 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 229193010684 probable transmembrane helix predicted by TMHMM2.0 229193010685 heme exporter protein CcmC; Region: ccmC; TIGR01191 229193010686 probable transmembrane helix predicted by TMHMM2.0 229193010687 probable transmembrane helix predicted by TMHMM2.0 229193010688 probable transmembrane helix predicted by TMHMM2.0 229193010689 probable transmembrane helix predicted by TMHMM2.0 229193010690 probable transmembrane helix predicted by TMHMM2.0 229193010691 probable transmembrane helix predicted by TMHMM2.0 229193010692 heme exporter protein CcmB; Region: ccmB; TIGR01190 229193010693 probable transmembrane helix predicted by TMHMM2.0 229193010694 probable transmembrane helix predicted by TMHMM2.0 229193010695 ProfileScan match to entry PS50319 LEU_RICH, E-value 11.052 229193010696 probable transmembrane helix predicted by TMHMM2.0 229193010697 probable transmembrane helix predicted by TMHMM2.0 229193010698 probable transmembrane helix predicted by TMHMM2.0 229193010699 probable transmembrane helix predicted by TMHMM2.0 229193010700 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 229193010701 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 229193010702 Walker A/P-loop; other site 229193010703 ATP binding site [chemical binding]; other site 229193010704 Q-loop/lid; other site 229193010705 ABC transporter signature motif; other site 229193010706 Walker B; other site 229193010707 D-loop; other site 229193010708 H-loop/switch region; other site 229193010709 probable transmembrane helix predicted by TMHMM2.0 229193010710 probable transmembrane helix predicted by TMHMM2.0 229193010711 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 229193010712 HMMPfam match to entry PF04011 LemA, E-value 5.1e-52 229193010713 probable transmembrane helix predicted by TMHMM2.0 229193010714 probable transmembrane helix predicted by TMHMM2.0 229193010715 probable transmembrane helix predicted by TMHMM2.0 229193010716 probable transmembrane helix predicted by TMHMM2.0 229193010717 ProfileScan match to entry PS50319 LEU_RICH, E-value 10.482 229193010718 probable transmembrane helix predicted by TMHMM2.0 229193010719 probable transmembrane helix predicted by TMHMM2.0 229193010720 ProfileScan match to entry PS50324 SER_RICH, E-value 15.115 229193010721 ProfileScan match to entry PS50315 GLY_RICH, E-value 10.416 229193010722 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 229193010723 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 229193010724 PhnA protein; Region: PhnA; pfam03831 229193010725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193010726 MULE transposase domain; Region: MULE; pfam10551 229193010727 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 229193010728 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 229193010729 ImpE protein; Region: ImpE; pfam07024 229193010730 PAAR motif; Region: PAAR_motif; pfam05488 229193010731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 229193010732 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 229193010733 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 229193010734 ProfileScan match to entry PS50315 GLY_RICH, E-value 8.908 229193010735 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 229193010736 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 229193010737 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 229193010738 probable transmembrane helix predicted by TMHMM2.0 229193010739 probable transmembrane helix predicted by TMHMM2.0 229193010740 probable transmembrane helix predicted by TMHMM2.0 229193010741 probable transmembrane helix predicted by TMHMM2.0 229193010742 probable transmembrane helix predicted by TMHMM2.0 229193010743 transposase/IS protein; Provisional; Region: PRK09183 229193010744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193010745 Walker A motif; other site 229193010746 ATP binding site [chemical binding]; other site 229193010747 Walker B motif; other site 229193010748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193010749 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193010750 DNA-binding interface [nucleotide binding]; DNA binding site 229193010751 Integrase core domain; Region: rve; pfam00665 229193010752 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 229193010753 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 229193010754 HMMPfam match to entry PF04069 OpuAC, E-value 4.2e-63 229193010755 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 229193010756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193010757 dimer interface [polypeptide binding]; other site 229193010758 conserved gate region; other site 229193010759 putative PBP binding loops; other site 229193010760 ABC-ATPase subunit interface; other site 229193010761 probable transmembrane helix predicted by TMHMM2.0 229193010762 probable transmembrane helix predicted by TMHMM2.0 229193010763 probable transmembrane helix predicted by TMHMM2.0 229193010764 probable transmembrane helix predicted by TMHMM2.0 229193010765 probable transmembrane helix predicted by TMHMM2.0 229193010766 probable transmembrane helix predicted by TMHMM2.0 229193010767 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 229193010768 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 229193010769 Walker A/P-loop; other site 229193010770 ATP binding site [chemical binding]; other site 229193010771 Q-loop/lid; other site 229193010772 ABC transporter signature motif; other site 229193010773 Walker B; other site 229193010774 D-loop; other site 229193010775 H-loop/switch region; other site 229193010776 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 229193010777 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 229193010778 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 229193010779 dimer interface [polypeptide binding]; other site 229193010780 putative radical transfer pathway; other site 229193010781 diiron center [ion binding]; other site 229193010782 tyrosyl radical; other site 229193010783 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 229193010784 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 229193010785 Class I ribonucleotide reductase; Region: RNR_I; cd01679 229193010786 active site 229193010787 dimer interface [polypeptide binding]; other site 229193010788 catalytic residues [active] 229193010789 effector binding site; other site 229193010790 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 229193010791 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 229193010792 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 229193010793 catalytic residues [active] 229193010794 ProfileScan match to entry PS50318 LYS_RICH, E-value 10.791 229193010795 hypothetical protein; Provisional; Region: PRK10556 229193010796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193010797 MULE transposase domain; Region: MULE; pfam10551 229193010798 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 229193010799 probable transmembrane helix predicted by TMHMM2.0 229193010800 MbeD/MobD like; Region: MbeD_MobD; pfam04899 229193010801 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 229193010802 DNA-binding site [nucleotide binding]; DNA binding site 229193010803 RNA-binding motif; other site 229193010804 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 229193010805 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 229193010806 probable transmembrane helix predicted by TMHMM2.0 229193010807 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 229193010808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193010809 dimer interface [polypeptide binding]; other site 229193010810 conserved gate region; other site 229193010811 putative PBP binding loops; other site 229193010812 ABC-ATPase subunit interface; other site 229193010813 probable transmembrane helix predicted by TMHMM2.0 229193010814 probable transmembrane helix predicted by TMHMM2.0 229193010815 probable transmembrane helix predicted by TMHMM2.0 229193010816 probable transmembrane helix predicted by TMHMM2.0 229193010817 probable transmembrane helix predicted by TMHMM2.0 229193010818 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 229193010819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193010820 dimer interface [polypeptide binding]; other site 229193010821 conserved gate region; other site 229193010822 putative PBP binding loops; other site 229193010823 ABC-ATPase subunit interface; other site 229193010824 probable transmembrane helix predicted by TMHMM2.0 229193010825 probable transmembrane helix predicted by TMHMM2.0 229193010826 probable transmembrane helix predicted by TMHMM2.0 229193010827 probable transmembrane helix predicted by TMHMM2.0 229193010828 probable transmembrane helix predicted by TMHMM2.0 229193010829 probable transmembrane helix predicted by TMHMM2.0 229193010830 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193010831 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 229193010832 Walker A/P-loop; other site 229193010833 ATP binding site [chemical binding]; other site 229193010834 Q-loop/lid; other site 229193010835 ABC transporter signature motif; other site 229193010836 Walker B; other site 229193010837 D-loop; other site 229193010838 H-loop/switch region; other site 229193010839 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 229193010840 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193010841 Walker A/P-loop; other site 229193010842 ATP binding site [chemical binding]; other site 229193010843 Q-loop/lid; other site 229193010844 ABC transporter signature motif; other site 229193010845 Walker B; other site 229193010846 D-loop; other site 229193010847 H-loop/switch region; other site 229193010848 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 229193010849 alpha-gamma subunit interface [polypeptide binding]; other site 229193010850 beta-gamma subunit interface [polypeptide binding]; other site 229193010851 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 229193010852 alpha-beta subunit interface [polypeptide binding]; other site 229193010853 urease subunit alpha; Reviewed; Region: ureC; PRK13309 229193010854 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 229193010855 subunit interactions [polypeptide binding]; other site 229193010856 active site 229193010857 flap region; other site 229193010858 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 229193010859 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 229193010860 dimer interface [polypeptide binding]; other site 229193010861 catalytic residues [active] 229193010862 HMMPfam match to entry PF05194 UreE_C, E-value 5.1e-29 229193010863 ProfileScan match to entry PS50316 HIS_RICH, E-value 17.808 229193010864 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 229193010865 UreF; Region: UreF; pfam01730 229193010866 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378 229193010867 Contains Urease accessory protein UreD (Interpro|IPR002669, (GO:0006807), (GO:0016151)) . Contains Urease accessory protein UreD (Interpro|IPR002669, (GO:0006807), (GO:0016151)) 229193010868 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 229193010869 probable transmembrane helix predicted by TMHMM2.0 229193010870 probable transmembrane helix predicted by TMHMM2.0 229193010871 probable transmembrane helix predicted by TMHMM2.0 229193010872 probable transmembrane helix predicted by TMHMM2.0 229193010873 probable transmembrane helix predicted by TMHMM2.0 229193010874 probable transmembrane helix predicted by TMHMM2.0 229193010875 probable transmembrane helix predicted by TMHMM2.0 229193010876 probable transmembrane helix predicted by TMHMM2.0 229193010877 probable transmembrane helix predicted by TMHMM2.0 229193010878 probable transmembrane helix predicted by TMHMM2.0 229193010879 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 229193010880 probable transmembrane helix predicted by TMHMM2.0 229193010881 probable transmembrane helix predicted by TMHMM2.0 229193010882 probable transmembrane helix predicted by TMHMM2.0 229193010883 probable transmembrane helix predicted by TMHMM2.0 229193010884 probable transmembrane helix predicted by TMHMM2.0 229193010885 probable transmembrane helix predicted by TMHMM2.0 229193010886 probable transmembrane helix predicted by TMHMM2.0 229193010887 probable transmembrane helix predicted by TMHMM2.0 229193010888 acid-resistance protein; Provisional; Region: hdeB; PRK11566 229193010889 voltage-gated potassium channel; Provisional; Region: PRK10537 229193010890 Ion channel; Region: Ion_trans_2; pfam07885 229193010891 TrkA-N domain; Region: TrkA_N; pfam02254 229193010892 probable transmembrane helix predicted by TMHMM2.0 229193010893 probable transmembrane helix predicted by TMHMM2.0 229193010894 probable transmembrane helix predicted by TMHMM2.0 229193010895 probable transmembrane helix predicted by TMHMM2.0 229193010896 probable transmembrane helix predicted by TMHMM2.0 229193010897 probable transmembrane helix predicted by TMHMM2.0 229193010898 probable transmembrane helix predicted by TMHMM2.0 229193010899 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636 229193010900 probable transmembrane helix predicted by TMHMM2.0 229193010901 probable transmembrane helix predicted by TMHMM2.0 229193010902 probable transmembrane helix predicted by TMHMM2.0 229193010903 probable transmembrane helix predicted by TMHMM2.0 229193010904 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 229193010905 probable transmembrane helix predicted by TMHMM2.0 229193010906 probable transmembrane helix predicted by TMHMM2.0 229193010907 probable transmembrane helix predicted by TMHMM2.0 229193010908 probable transmembrane helix predicted by TMHMM2.0 229193010909 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 229193010910 active site 229193010911 P-loop; other site 229193010912 phosphorylation site [posttranslational modification] 229193010913 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 229193010914 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 229193010915 probable transmembrane helix predicted by TMHMM2.0 229193010916 probable transmembrane helix predicted by TMHMM2.0 229193010917 probable transmembrane helix predicted by TMHMM2.0 229193010918 probable transmembrane helix predicted by TMHMM2.0 229193010919 probable transmembrane helix predicted by TMHMM2.0 229193010920 probable transmembrane helix predicted by TMHMM2.0 229193010921 probable transmembrane helix predicted by TMHMM2.0 229193010922 probable transmembrane helix predicted by TMHMM2.0 229193010923 probable transmembrane helix predicted by TMHMM2.0 229193010924 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 229193010925 methionine cluster; other site 229193010926 active site 229193010927 phosphorylation site [posttranslational modification] 229193010928 metal binding site [ion binding]; metal-binding site 229193010929 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 229193010930 Cupin domain; Region: Cupin_2; cl17218 229193010931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193010932 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 229193010933 putative active site [active] 229193010934 YdjC motif; other site 229193010935 Mg binding site [ion binding]; other site 229193010936 putative homodimer interface [polypeptide binding]; other site 229193010937 probable transmembrane helix predicted by TMHMM2.0 229193010938 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 229193010939 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 229193010940 replication initiation regulator SeqA; Provisional; Region: PRK11187 229193010941 phosphoglucomutase; Validated; Region: PRK07564 229193010942 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 229193010943 active site 229193010944 substrate binding site [chemical binding]; other site 229193010945 metal binding site [ion binding]; metal-binding site 229193010946 Predicted membrane protein [Function unknown]; Region: COG2510 229193010947 probable transmembrane helix predicted by TMHMM2.0 229193010948 probable transmembrane helix predicted by TMHMM2.0 229193010949 probable transmembrane helix predicted by TMHMM2.0 229193010950 probable transmembrane helix predicted by TMHMM2.0 229193010951 probable transmembrane helix predicted by TMHMM2.0 229193010952 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 229193010953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193010954 active site 229193010955 phosphorylation site [posttranslational modification] 229193010956 intermolecular recognition site; other site 229193010957 dimerization interface [polypeptide binding]; other site 229193010958 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193010959 DNA binding site [nucleotide binding] 229193010960 sensor protein KdpD; Provisional; Region: PRK10490 229193010961 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 229193010962 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 229193010963 Ligand Binding Site [chemical binding]; other site 229193010964 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 229193010965 GAF domain; Region: GAF_3; pfam13492 229193010966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193010967 dimer interface [polypeptide binding]; other site 229193010968 phosphorylation site [posttranslational modification] 229193010969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193010970 ATP binding site [chemical binding]; other site 229193010971 Mg2+ binding site [ion binding]; other site 229193010972 G-X-G motif; other site 229193010973 probable transmembrane helix predicted by TMHMM2.0 229193010974 probable transmembrane helix predicted by TMHMM2.0 229193010975 probable transmembrane helix predicted by TMHMM2.0 229193010976 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 229193010977 probable transmembrane helix predicted by TMHMM2.0 229193010978 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 229193010979 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 229193010980 probable transmembrane helix predicted by TMHMM2.0 229193010981 probable transmembrane helix predicted by TMHMM2.0 229193010982 probable transmembrane helix predicted by TMHMM2.0 229193010983 probable transmembrane helix predicted by TMHMM2.0 229193010984 probable transmembrane helix predicted by TMHMM2.0 229193010985 probable transmembrane helix predicted by TMHMM2.0 229193010986 probable transmembrane helix predicted by TMHMM2.0 229193010987 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 229193010988 probable transmembrane helix predicted by TMHMM2.0 229193010989 probable transmembrane helix predicted by TMHMM2.0 229193010990 probable transmembrane helix predicted by TMHMM2.0 229193010991 probable transmembrane helix predicted by TMHMM2.0 229193010992 probable transmembrane helix predicted by TMHMM2.0 229193010993 probable transmembrane helix predicted by TMHMM2.0 229193010994 probable transmembrane helix predicted by TMHMM2.0 229193010995 probable transmembrane helix predicted by TMHMM2.0 229193010996 probable transmembrane helix predicted by TMHMM2.0 229193010997 probable transmembrane helix predicted by TMHMM2.0 229193010998 probable transmembrane helix predicted by TMHMM2.0 229193010999 probable transmembrane helix predicted by TMHMM2.0 229193011000 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 229193011001 probable transmembrane helix predicted by TMHMM2.0 229193011002 hypothetical protein; Provisional; Region: PRK10167 229193011003 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 229193011004 DNA photolyase; Region: DNA_photolyase; pfam00875 229193011005 BlastProDom match to entry PD002476 sp_P00914_PHR_ECOLI, E-value 5e-40 229193011006 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 229193011007 Uncharacterized conserved protein [Function unknown]; Region: COG0327 229193011008 metal-binding protein; Provisional; Region: PRK10799 229193011009 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 229193011010 HMMTigr match to entry TIGR00724 urea_amlyse_rel, E-value 6.1e-157 229193011011 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 229193011012 putative active site [active] 229193011013 Predicted membrane protein [Function unknown]; Region: COG3819 229193011014 Predicted membrane protein [Function unknown]; Region: COG3817 229193011015 Protein of unknown function (DUF979); Region: DUF979; pfam06166 229193011016 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 229193011017 putative substrate binding pocket [chemical binding]; other site 229193011018 AC domain interface; other site 229193011019 catalytic triad [active] 229193011020 AB domain interface; other site 229193011021 interchain disulfide; other site 229193011022 ProfileScan match to entry PS50315 GLY_RICH, E-value 9.319 229193011023 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 229193011024 ligand binding site [chemical binding]; other site 229193011025 active site 229193011026 UGI interface [polypeptide binding]; other site 229193011027 catalytic site [active] 229193011028 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 229193011029 BlastProDom match to entry PD004056 sp_P18953_YFID_SERLI, E-value 5e-47 229193011030 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 229193011031 nucleophilic elbow; other site 229193011032 catalytic triad; other site 229193011033 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 229193011034 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 229193011035 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 229193011036 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 229193011037 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 229193011038 ATP binding site [chemical binding]; other site 229193011039 Mg++ binding site [ion binding]; other site 229193011040 motif III; other site 229193011041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193011042 nucleotide binding region [chemical binding]; other site 229193011043 ATP-binding site [chemical binding]; other site 229193011044 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 229193011045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193011046 S-adenosylmethionine binding site [chemical binding]; other site 229193011047 L-aspartate oxidase; Provisional; Region: PRK09077 229193011048 L-aspartate oxidase; Provisional; Region: PRK06175 229193011049 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 229193011050 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 229193011051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 229193011052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 229193011053 DNA binding residues [nucleotide binding] 229193011054 HMMPfam match to entry PF04542 sigma70_r2, E-value 2.1e-19 229193011055 HMMPfam match to entry PF04545 sigma70_r4, E-value 3.8e-15 229193011056 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 229193011057 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 229193011058 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 229193011059 ProfileScan match to entry PS50322 GLN_RICH, E-value 9.524 229193011060 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 229193011061 anti-sigma E factor; Provisional; Region: rseB; PRK09455 229193011062 SoxR reducing system protein RseC; Provisional; Region: PRK10862 229193011063 HMMPfam match to entry PF04246 RseC_MucC, E-value 5e-43 229193011064 probable transmembrane helix predicted by TMHMM2.0 229193011065 probable transmembrane helix predicted by TMHMM2.0 229193011066 probable transmembrane helix predicted by TMHMM2.0 229193011067 probable transmembrane helix predicted by TMHMM2.0 229193011068 GTP-binding protein LepA; Provisional; Region: PRK05433 229193011069 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 229193011070 G1 box; other site 229193011071 putative GEF interaction site [polypeptide binding]; other site 229193011072 GTP/Mg2+ binding site [chemical binding]; other site 229193011073 Switch I region; other site 229193011074 G2 box; other site 229193011075 G3 box; other site 229193011076 Switch II region; other site 229193011077 G4 box; other site 229193011078 G5 box; other site 229193011079 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 229193011080 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 229193011081 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 229193011082 signal peptidase I; Provisional; Region: PRK10861 229193011083 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 229193011084 Catalytic site [active] 229193011085 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 229193011086 probable transmembrane helix predicted by TMHMM2.0 229193011087 probable transmembrane helix predicted by TMHMM2.0 229193011088 ribonuclease III; Reviewed; Region: rnc; PRK00102 229193011089 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 229193011090 dimerization interface [polypeptide binding]; other site 229193011091 active site 229193011092 metal binding site [ion binding]; metal-binding site 229193011093 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 229193011094 dsRNA binding site [nucleotide binding]; other site 229193011095 GTPase Era; Reviewed; Region: era; PRK00089 229193011096 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 229193011097 G1 box; other site 229193011098 GTP/Mg2+ binding site [chemical binding]; other site 229193011099 Switch I region; other site 229193011100 G2 box; other site 229193011101 Switch II region; other site 229193011102 G3 box; other site 229193011103 G4 box; other site 229193011104 G5 box; other site 229193011105 KH domain; Region: KH_2; pfam07650 229193011106 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 229193011107 Recombination protein O N terminal; Region: RecO_N; pfam11967 229193011108 Recombination protein O C terminal; Region: RecO_C; pfam02565 229193011109 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 229193011110 active site 229193011111 hydrophilic channel; other site 229193011112 dimerization interface [polypeptide binding]; other site 229193011113 catalytic residues [active] 229193011114 active site lid [active] 229193011115 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 229193011116 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193011117 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 229193011118 highly similar to RpiR-family transcriptional regulatory protein [Yersinia pestis CO92]; disrupted by IS100 element 229193011119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193011120 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193011121 DNA-binding interface [nucleotide binding]; DNA binding site 229193011122 Integrase core domain; Region: rve; pfam00665 229193011123 transposase/IS protein; Provisional; Region: PRK09183 229193011124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193011125 Walker A motif; other site 229193011126 ATP binding site [chemical binding]; other site 229193011127 Walker B motif; other site 229193011128 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 229193011129 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 229193011130 putative active site [active] 229193011131 haloacid dehalogenase superfamily, subfamily IF hydrolase, YfhB; Region: YfhB_g-proteo; TIGR01545 229193011132 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 229193011133 probable transmembrane helix predicted by TMHMM2.0 229193011134 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 229193011135 nucleoside/Zn binding site; other site 229193011136 dimer interface [polypeptide binding]; other site 229193011137 catalytic motif [active] 229193011138 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 229193011139 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193011140 substrate binding pocket [chemical binding]; other site 229193011141 membrane-bound complex binding site; other site 229193011142 hinge residues; other site 229193011143 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 229193011144 N-acetyl-D-glucosamine binding site [chemical binding]; other site 229193011145 catalytic residue [active] 229193011146 probable transmembrane helix predicted by TMHMM2.0 229193011147 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 229193011148 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 229193011149 dimerization interface [polypeptide binding]; other site 229193011150 ATP binding site [chemical binding]; other site 229193011151 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 229193011152 dimerization interface [polypeptide binding]; other site 229193011153 ATP binding site [chemical binding]; other site 229193011154 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 229193011155 putative active site [active] 229193011156 catalytic triad [active] 229193011157 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 229193011158 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 229193011159 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193011160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 229193011161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193011162 dimer interface [polypeptide binding]; other site 229193011163 phosphorylation site [posttranslational modification] 229193011164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193011165 ATP binding site [chemical binding]; other site 229193011166 Mg2+ binding site [ion binding]; other site 229193011167 G-X-G motif; other site 229193011168 probable transmembrane helix predicted by TMHMM2.0 229193011169 probable transmembrane helix predicted by TMHMM2.0 229193011170 hypothetical protein; Provisional; Region: PRK10722 229193011171 response regulator GlrR; Provisional; Region: PRK15115 229193011172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193011173 active site 229193011174 phosphorylation site [posttranslational modification] 229193011175 intermolecular recognition site; other site 229193011176 dimerization interface [polypeptide binding]; other site 229193011177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193011178 Walker A motif; other site 229193011179 ATP binding site [chemical binding]; other site 229193011180 Walker B motif; other site 229193011181 arginine finger; other site 229193011182 ProfileScan match to entry PS50116 HTH_FIS_FAMILY, E-value 11.425 229193011183 NAD synthetase; Provisional; Region: PRK13981 229193011184 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 229193011185 multimer interface [polypeptide binding]; other site 229193011186 active site 229193011187 catalytic triad [active] 229193011188 protein interface 1 [polypeptide binding]; other site 229193011189 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 229193011190 homodimer interface [polypeptide binding]; other site 229193011191 NAD binding pocket [chemical binding]; other site 229193011192 ATP binding pocket [chemical binding]; other site 229193011193 Mg binding site [ion binding]; other site 229193011194 active-site loop [active] 229193011195 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 229193011196 Nitrogen regulatory protein P-II; Region: P-II; smart00938 229193011197 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 229193011198 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 229193011199 heme-binding site [chemical binding]; other site 229193011200 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 229193011201 FAD binding pocket [chemical binding]; other site 229193011202 FAD binding motif [chemical binding]; other site 229193011203 phosphate binding motif [ion binding]; other site 229193011204 beta-alpha-beta structure motif; other site 229193011205 NAD binding pocket [chemical binding]; other site 229193011206 Heme binding pocket [chemical binding]; other site 229193011207 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 229193011208 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 229193011209 dimer interface [polypeptide binding]; other site 229193011210 active site 229193011211 glycine-pyridoxal phosphate binding site [chemical binding]; other site 229193011212 folate binding site [chemical binding]; other site 229193011213 probable transmembrane helix predicted by TMHMM2.0 229193011214 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 229193011215 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 229193011216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193011217 putative substrate translocation pore; other site 229193011218 probable transmembrane helix predicted by TMHMM2.0 229193011219 probable transmembrane helix predicted by TMHMM2.0 229193011220 probable transmembrane helix predicted by TMHMM2.0 229193011221 probable transmembrane helix predicted by TMHMM2.0 229193011222 probable transmembrane helix predicted by TMHMM2.0 229193011223 probable transmembrane helix predicted by TMHMM2.0 229193011224 probable transmembrane helix predicted by TMHMM2.0 229193011225 probable transmembrane helix predicted by TMHMM2.0 229193011226 probable transmembrane helix predicted by TMHMM2.0 229193011227 probable transmembrane helix predicted by TMHMM2.0 229193011228 probable transmembrane helix predicted by TMHMM2.0 229193011229 probable transmembrane helix predicted by TMHMM2.0 229193011230 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 229193011231 PRD domain; Region: PRD; pfam00874 229193011232 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 229193011233 probable transmembrane helix predicted by TMHMM2.0 229193011234 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 229193011235 probable transmembrane helix predicted by TMHMM2.0 229193011236 probable transmembrane helix predicted by TMHMM2.0 229193011237 probable transmembrane helix predicted by TMHMM2.0 229193011238 probable transmembrane helix predicted by TMHMM2.0 229193011239 probable transmembrane helix predicted by TMHMM2.0 229193011240 probable transmembrane helix predicted by TMHMM2.0 229193011241 probable transmembrane helix predicted by TMHMM2.0 229193011242 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 229193011243 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 229193011244 active site 229193011245 dimerization interface [polypeptide binding]; other site 229193011246 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 229193011247 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 229193011248 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 229193011249 Rrf2 family protein; Region: rrf2_super; TIGR00738 229193011250 cysteine desulfurase; Provisional; Region: PRK14012 229193011251 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 229193011252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193011253 catalytic residue [active] 229193011254 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 229193011255 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 229193011256 trimerization site [polypeptide binding]; other site 229193011257 active site 229193011258 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 229193011259 co-chaperone HscB; Provisional; Region: hscB; PRK05014 229193011260 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 229193011261 HSP70 interaction site [polypeptide binding]; other site 229193011262 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 229193011263 chaperone protein HscA; Provisional; Region: hscA; PRK05183 229193011264 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 229193011265 nucleotide binding site [chemical binding]; other site 229193011266 putative NEF/HSP70 interaction site [polypeptide binding]; other site 229193011267 SBD interface [polypeptide binding]; other site 229193011268 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 229193011269 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 229193011270 catalytic loop [active] 229193011271 iron binding site [ion binding]; other site 229193011272 hypothetical protein; Provisional; Region: PRK10721 229193011273 HMMPfam match to entry PF04384 DUF528, E-value 1.4e-40 229193011274 aminopeptidase B; Provisional; Region: PRK05015 229193011275 Peptidase; Region: DUF3663; pfam12404 229193011276 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 229193011277 interface (dimer of trimers) [polypeptide binding]; other site 229193011278 Substrate-binding/catalytic site; other site 229193011279 Zn-binding sites [ion binding]; other site 229193011280 SseB protein; Region: SseB; pfam07179 229193011281 Contains Pertactin virulence factor, C-terminal (Interpro|IPR003991, (GO:0007155)) . Contains Pertactin virulence factor, C-terminal (Interpro|IPR003991, (GO:0007155)). Contains Pertactin domain (Interpro|IPR004899) 229193011282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193011283 MULE transposase domain; Region: MULE; pfam10551 229193011284 putative chaperone protein EcpD; Provisional; Region: PRK09926 229193011285 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193011286 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 229193011287 probable transmembrane helix predicted by TMHMM2.0 229193011288 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 229193011289 probable transmembrane helix predicted by TMHMM2.0 229193011290 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 229193011291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193011292 Walker A motif; other site 229193011293 ATP binding site [chemical binding]; other site 229193011294 Walker B motif; other site 229193011295 arginine finger; other site 229193011296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193011297 Walker A motif; other site 229193011298 ATP binding site [chemical binding]; other site 229193011299 Walker B motif; other site 229193011300 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 229193011301 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 229193011302 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 229193011303 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 229193011304 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 229193011305 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 229193011306 ProfileScan match to entry PS50322 GLN_RICH, E-value 9.781 229193011307 Fimbrial protein; Region: Fimbrial; pfam00419 229193011308 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 229193011309 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 229193011310 ligand binding site [chemical binding]; other site 229193011311 probable transmembrane helix predicted by TMHMM2.0 229193011312 probable transmembrane helix predicted by TMHMM2.0 229193011313 Uncharacterized conserved protein [Function unknown]; Region: COG5435 229193011314 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 229193011315 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193011316 DNA binding residues [nucleotide binding] 229193011317 dimerization interface [polypeptide binding]; other site 229193011318 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 229193011319 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 229193011320 N-acetyl-D-glucosamine binding site [chemical binding]; other site 229193011321 catalytic residue [active] 229193011322 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 229193011323 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 229193011324 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 229193011325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193011326 dimer interface [polypeptide binding]; other site 229193011327 conserved gate region; other site 229193011328 putative PBP binding loops; other site 229193011329 ABC-ATPase subunit interface; other site 229193011330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193011331 dimer interface [polypeptide binding]; other site 229193011332 conserved gate region; other site 229193011333 putative PBP binding loops; other site 229193011334 ABC-ATPase subunit interface; other site 229193011335 probable transmembrane helix predicted by TMHMM2.0 229193011336 probable transmembrane helix predicted by TMHMM2.0 229193011337 probable transmembrane helix predicted by TMHMM2.0 229193011338 probable transmembrane helix predicted by TMHMM2.0 229193011339 probable transmembrane helix predicted by TMHMM2.0 229193011340 probable transmembrane helix predicted by TMHMM2.0 229193011341 probable transmembrane helix predicted by TMHMM2.0 229193011342 probable transmembrane helix predicted by TMHMM2.0 229193011343 probable transmembrane helix predicted by TMHMM2.0 229193011344 probable transmembrane helix predicted by TMHMM2.0 229193011345 probable transmembrane helix predicted by TMHMM2.0 229193011346 probable transmembrane helix predicted by TMHMM2.0 229193011347 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 229193011348 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 229193011349 Walker A/P-loop; other site 229193011350 ATP binding site [chemical binding]; other site 229193011351 Q-loop/lid; other site 229193011352 ABC transporter signature motif; other site 229193011353 Walker B; other site 229193011354 D-loop; other site 229193011355 H-loop/switch region; other site 229193011356 Predicted membrane protein [Function unknown]; Region: COG4331 229193011357 probable transmembrane helix predicted by TMHMM2.0 229193011358 probable transmembrane helix predicted by TMHMM2.0 229193011359 probable transmembrane helix predicted by TMHMM2.0 229193011360 probable transmembrane helix predicted by TMHMM2.0 229193011361 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 229193011362 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 229193011363 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 229193011364 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 229193011365 putative [Fe4-S4] binding site [ion binding]; other site 229193011366 putative molybdopterin cofactor binding site [chemical binding]; other site 229193011367 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 229193011368 putative molybdopterin cofactor binding site; other site 229193011369 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 229193011370 4Fe-4S binding domain; Region: Fer4; cl02805 229193011371 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 229193011372 probable transmembrane helix predicted by TMHMM2.0 229193011373 probable transmembrane helix predicted by TMHMM2.0 229193011374 probable transmembrane helix predicted by TMHMM2.0 229193011375 probable transmembrane helix predicted by TMHMM2.0 229193011376 probable transmembrane helix predicted by TMHMM2.0 229193011377 probable transmembrane helix predicted by TMHMM2.0 229193011378 probable transmembrane helix predicted by TMHMM2.0 229193011379 probable transmembrane helix predicted by TMHMM2.0 229193011380 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 229193011381 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 229193011382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 229193011383 probable transmembrane helix predicted by TMHMM2.0 229193011384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 229193011385 probable transmembrane helix predicted by TMHMM2.0 229193011386 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 229193011387 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 229193011388 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 229193011389 probable transmembrane helix predicted by TMHMM2.0 229193011390 probable transmembrane helix predicted by TMHMM2.0 229193011391 probable transmembrane helix predicted by TMHMM2.0 229193011392 probable transmembrane helix predicted by TMHMM2.0 229193011393 probable transmembrane helix predicted by TMHMM2.0 229193011394 aminotransferase; Validated; Region: PRK08175 229193011395 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 229193011396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193011397 homodimer interface [polypeptide binding]; other site 229193011398 catalytic residue [active] 229193011399 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 229193011400 glucokinase, proteobacterial type; Region: glk; TIGR00749 229193011401 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 229193011402 nucleotide binding site [chemical binding]; other site 229193011403 Predicted membrane protein [Function unknown]; Region: COG4125 229193011404 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 229193011405 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 229193011406 probable transmembrane helix predicted by TMHMM2.0 229193011407 probable transmembrane helix predicted by TMHMM2.0 229193011408 probable transmembrane helix predicted by TMHMM2.0 229193011409 probable transmembrane helix predicted by TMHMM2.0 229193011410 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193011411 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193011412 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 229193011413 dimerization interface [polypeptide binding]; other site 229193011414 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 229193011415 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 229193011416 active site 229193011417 catalytic tetrad [active] 229193011418 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 229193011419 manganese transport protein MntH; Reviewed; Region: PRK00701 229193011420 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 229193011421 probable transmembrane helix predicted by TMHMM2.0 229193011422 probable transmembrane helix predicted by TMHMM2.0 229193011423 probable transmembrane helix predicted by TMHMM2.0 229193011424 probable transmembrane helix predicted by TMHMM2.0 229193011425 probable transmembrane helix predicted by TMHMM2.0 229193011426 probable transmembrane helix predicted by TMHMM2.0 229193011427 probable transmembrane helix predicted by TMHMM2.0 229193011428 probable transmembrane helix predicted by TMHMM2.0 229193011429 probable transmembrane helix predicted by TMHMM2.0 229193011430 probable transmembrane helix predicted by TMHMM2.0 229193011431 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 229193011432 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 229193011433 Nucleoside recognition; Region: Gate; pfam07670 229193011434 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 229193011435 probable transmembrane helix predicted by TMHMM2.0 229193011436 probable transmembrane helix predicted by TMHMM2.0 229193011437 probable transmembrane helix predicted by TMHMM2.0 229193011438 probable transmembrane helix predicted by TMHMM2.0 229193011439 probable transmembrane helix predicted by TMHMM2.0 229193011440 probable transmembrane helix predicted by TMHMM2.0 229193011441 probable transmembrane helix predicted by TMHMM2.0 229193011442 probable transmembrane helix predicted by TMHMM2.0 229193011443 probable transmembrane helix predicted by TMHMM2.0 229193011444 probable transmembrane helix predicted by TMHMM2.0 229193011445 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 229193011446 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 229193011447 HIGH motif; other site 229193011448 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 229193011449 active site 229193011450 KMSKS motif; other site 229193011451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 229193011452 FlxA-like protein; Region: FlxA; pfam14282 229193011453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 229193011454 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 229193011455 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 229193011456 nucleotide binding pocket [chemical binding]; other site 229193011457 K-X-D-G motif; other site 229193011458 catalytic site [active] 229193011459 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 229193011460 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 229193011461 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 229193011462 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 229193011463 Dimer interface [polypeptide binding]; other site 229193011464 BRCT sequence motif; other site 229193011465 BlastProDom match to entry PD041672 sp_Q9RBF2_Q9RBF2_ALTHA, E-value 1e-20 229193011466 cell division protein ZipA; Provisional; Region: PRK03427 229193011467 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 229193011468 FtsZ protein binding site [polypeptide binding]; other site 229193011469 HMMPfam match to entry PF04354 ZipA_C, E-value 5.4e-79 229193011470 probable transmembrane helix predicted by TMHMM2.0 229193011471 putative sulfate transport protein CysZ; Validated; Region: PRK04949 229193011472 probable transmembrane helix predicted by TMHMM2.0 229193011473 HMMPfam match to entry PF04401 DUF540, E-value 5.8e-104 229193011474 probable transmembrane helix predicted by TMHMM2.0 229193011475 probable transmembrane helix predicted by TMHMM2.0 229193011476 probable transmembrane helix predicted by TMHMM2.0 229193011477 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 229193011478 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 229193011479 dimer interface [polypeptide binding]; other site 229193011480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193011481 catalytic residue [active] 229193011482 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 229193011483 dimerization domain swap beta strand [polypeptide binding]; other site 229193011484 regulatory protein interface [polypeptide binding]; other site 229193011485 active site 229193011486 regulatory phosphorylation site [posttranslational modification]; other site 229193011487 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 229193011488 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 229193011489 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 229193011490 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 229193011491 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 229193011492 HPr interaction site; other site 229193011493 glycerol kinase (GK) interaction site [polypeptide binding]; other site 229193011494 active site 229193011495 phosphorylation site [posttranslational modification] 229193011496 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193011497 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 229193011498 dimerization interface [polypeptide binding]; other site 229193011499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193011500 dimer interface [polypeptide binding]; other site 229193011501 phosphorylation site [posttranslational modification] 229193011502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193011503 ATP binding site [chemical binding]; other site 229193011504 Mg2+ binding site [ion binding]; other site 229193011505 G-X-G motif; other site 229193011506 probable transmembrane helix predicted by TMHMM2.0 229193011507 probable transmembrane helix predicted by TMHMM2.0 229193011508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 229193011509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193011510 active site 229193011511 phosphorylation site [posttranslational modification] 229193011512 intermolecular recognition site; other site 229193011513 dimerization interface [polypeptide binding]; other site 229193011514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193011515 DNA binding site [nucleotide binding] 229193011516 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 229193011517 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 229193011518 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193011519 probable transmembrane helix predicted by TMHMM2.0 229193011520 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 229193011521 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 229193011522 Walker A/P-loop; other site 229193011523 ATP binding site [chemical binding]; other site 229193011524 Q-loop/lid; other site 229193011525 ABC transporter signature motif; other site 229193011526 Walker B; other site 229193011527 D-loop; other site 229193011528 H-loop/switch region; other site 229193011529 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 229193011530 FtsX-like permease family; Region: FtsX; pfam02687 229193011531 BlastProDom match to entry PD039360 sp_Q57585_Y121_METJA, E-value 2e-09 229193011532 probable transmembrane helix predicted by TMHMM2.0 229193011533 probable transmembrane helix predicted by TMHMM2.0 229193011534 probable transmembrane helix predicted by TMHMM2.0 229193011535 probable transmembrane helix predicted by TMHMM2.0 229193011536 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 229193011537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 229193011538 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 229193011539 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 229193011540 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 229193011541 active site residue [active] 229193011542 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 229193011543 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 229193011544 Na binding site [ion binding]; other site 229193011545 probable transmembrane helix predicted by TMHMM2.0 229193011546 probable transmembrane helix predicted by TMHMM2.0 229193011547 probable transmembrane helix predicted by TMHMM2.0 229193011548 probable transmembrane helix predicted by TMHMM2.0 229193011549 probable transmembrane helix predicted by TMHMM2.0 229193011550 probable transmembrane helix predicted by TMHMM2.0 229193011551 probable transmembrane helix predicted by TMHMM2.0 229193011552 probable transmembrane helix predicted by TMHMM2.0 229193011553 probable transmembrane helix predicted by TMHMM2.0 229193011554 probable transmembrane helix predicted by TMHMM2.0 229193011555 probable transmembrane helix predicted by TMHMM2.0 229193011556 probable transmembrane helix predicted by TMHMM2.0 229193011557 probable transmembrane helix predicted by TMHMM2.0 229193011558 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 229193011559 probable transmembrane helix predicted by TMHMM2.0 229193011560 probable transmembrane helix predicted by TMHMM2.0 229193011561 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 229193011562 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 229193011563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193011564 homodimer interface [polypeptide binding]; other site 229193011565 catalytic residue [active] 229193011566 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 229193011567 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 229193011568 metal ion-dependent adhesion site (MIDAS); other site 229193011569 probable transmembrane helix predicted by TMHMM2.0 229193011570 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 229193011571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193011572 dimer interface [polypeptide binding]; other site 229193011573 phosphorylation site [posttranslational modification] 229193011574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193011575 ATP binding site [chemical binding]; other site 229193011576 Mg2+ binding site [ion binding]; other site 229193011577 G-X-G motif; other site 229193011578 probable transmembrane helix predicted by TMHMM2.0 229193011579 probable transmembrane helix predicted by TMHMM2.0 229193011580 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 229193011581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193011582 active site 229193011583 phosphorylation site [posttranslational modification] 229193011584 intermolecular recognition site; other site 229193011585 dimerization interface [polypeptide binding]; other site 229193011586 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193011587 DNA binding site [nucleotide binding] 229193011588 type III secretion protein GogB; Provisional; Region: PRK15386 229193011589 cysteine synthase B; Region: cysM; TIGR01138 229193011590 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 229193011591 dimer interface [polypeptide binding]; other site 229193011592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193011593 catalytic residue [active] 229193011594 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 229193011595 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 229193011596 Walker A/P-loop; other site 229193011597 ATP binding site [chemical binding]; other site 229193011598 Q-loop/lid; other site 229193011599 ABC transporter signature motif; other site 229193011600 Walker B; other site 229193011601 D-loop; other site 229193011602 H-loop/switch region; other site 229193011603 TOBE-like domain; Region: TOBE_3; pfam12857 229193011604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193011605 dimer interface [polypeptide binding]; other site 229193011606 conserved gate region; other site 229193011607 putative PBP binding loops; other site 229193011608 ABC-ATPase subunit interface; other site 229193011609 probable transmembrane helix predicted by TMHMM2.0 229193011610 probable transmembrane helix predicted by TMHMM2.0 229193011611 probable transmembrane helix predicted by TMHMM2.0 229193011612 probable transmembrane helix predicted by TMHMM2.0 229193011613 probable transmembrane helix predicted by TMHMM2.0 229193011614 probable transmembrane helix predicted by TMHMM2.0 229193011615 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 229193011616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193011617 dimer interface [polypeptide binding]; other site 229193011618 conserved gate region; other site 229193011619 putative PBP binding loops; other site 229193011620 ABC-ATPase subunit interface; other site 229193011621 probable transmembrane helix predicted by TMHMM2.0 229193011622 probable transmembrane helix predicted by TMHMM2.0 229193011623 probable transmembrane helix predicted by TMHMM2.0 229193011624 probable transmembrane helix predicted by TMHMM2.0 229193011625 probable transmembrane helix predicted by TMHMM2.0 229193011626 probable transmembrane helix predicted by TMHMM2.0 229193011627 probable transmembrane helix predicted by TMHMM2.0 229193011628 thiosulfate transporter subunit; Provisional; Region: PRK10852 229193011629 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 229193011630 probable transmembrane helix predicted by TMHMM2.0 229193011631 putative sialic acid transporter; Provisional; Region: PRK03893 229193011632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193011633 putative substrate translocation pore; other site 229193011634 probable transmembrane helix predicted by TMHMM2.0 229193011635 probable transmembrane helix predicted by TMHMM2.0 229193011636 probable transmembrane helix predicted by TMHMM2.0 229193011637 probable transmembrane helix predicted by TMHMM2.0 229193011638 probable transmembrane helix predicted by TMHMM2.0 229193011639 probable transmembrane helix predicted by TMHMM2.0 229193011640 probable transmembrane helix predicted by TMHMM2.0 229193011641 probable transmembrane helix predicted by TMHMM2.0 229193011642 probable transmembrane helix predicted by TMHMM2.0 229193011643 probable transmembrane helix predicted by TMHMM2.0 229193011644 probable transmembrane helix predicted by TMHMM2.0 229193011645 probable transmembrane helix predicted by TMHMM2.0 229193011646 probable transmembrane helix predicted by TMHMM2.0 229193011647 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 229193011648 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 229193011649 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 229193011650 putative active site [active] 229193011651 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 229193011652 N-acetylmannosamine kinase; Provisional; Region: PRK05082 229193011653 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 229193011654 nucleotide binding site [chemical binding]; other site 229193011655 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 229193011656 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 229193011657 Leucine-rich repeats; other site 229193011658 Substrate binding site [chemical binding]; other site 229193011659 Leucine rich repeat; Region: LRR_8; pfam13855 229193011660 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 229193011661 ProfileScan match to entry PS50319 LEU_RICH, E-value 8.628 229193011662 HMMSmart match to entry SM00364 LRR_BAC, E-value 86 229193011663 HMMSmart match to entry SM00364 LRR_BAC, E-value 13 229193011664 HMMSmart match to entry SM00364 LRR_BAC, E-value 5.8 229193011665 HMMSmart match to entry SM00364 LRR_BAC, E-value 8.5 229193011666 HMMSmart match to entry SM00364 LRR_BAC, E-value 5.4 229193011667 HMMSmart match to entry SM00364 LRR_BAC, E-value 18 229193011668 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.0022 229193011669 HMMSmart match to entry SM00364 LRR_BAC, E-value 6.4 229193011670 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 229193011671 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 229193011672 putative active site cavity [active] 229193011673 HMMPfam match to entry PF04131 nanE, E-value 1.8e-111 229193011674 BlastProDom match to entry PD023458 sp_Q9L6B4_Q9L6B4_PASMU, E-value 2e-51 229193011675 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 229193011676 Class I aldolases; Region: Aldolase_Class_I; cl17187 229193011677 catalytic residue [active] 229193011678 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 229193011679 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 229193011680 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 229193011681 probable transmembrane helix predicted by TMHMM2.0 229193011682 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 229193011683 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 229193011684 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 229193011685 Autotransporter beta-domain; Region: Autotransporter; pfam03797 229193011686 probable transmembrane helix predicted by TMHMM2.0 229193011687 probable transmembrane helix predicted by TMHMM2.0 229193011688 probable transmembrane helix predicted by TMHMM2.0 229193011689 probable transmembrane helix predicted by TMHMM2.0 229193011690 putative acetyltransferase; Provisional; Region: PRK03624 229193011691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 229193011692 Coenzyme A binding pocket [chemical binding]; other site 229193011693 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 229193011694 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 229193011695 hypothetical protein; Validated; Region: PRK00124 229193011696 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 229193011697 Malic enzyme, N-terminal domain; Region: malic; pfam00390 229193011698 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 229193011699 putative NAD(P) binding site [chemical binding]; other site 229193011700 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 229193011701 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 229193011702 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 229193011703 dimer interface [polypeptide binding]; other site 229193011704 ADP-ribose binding site [chemical binding]; other site 229193011705 active site 229193011706 nudix motif; other site 229193011707 metal binding site [ion binding]; metal-binding site 229193011708 cytochrome c-type protein NapC; Provisional; Region: PRK10617 229193011709 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 229193011710 probable transmembrane helix predicted by TMHMM2.0 229193011711 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 229193011712 BlastProDom match to entry PD012898 sp_P33933_NAPB_ECOLI, E-value 3e-53 229193011713 probable transmembrane helix predicted by TMHMM2.0 229193011714 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 229193011715 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 229193011716 [4Fe-4S] binding site [ion binding]; other site 229193011717 molybdopterin cofactor binding site; other site 229193011718 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 229193011719 molybdopterin cofactor binding site; other site 229193011720 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 229193011721 ferredoxin-type protein; Provisional; Region: PRK10194 229193011722 transcriptional regulator NarP; Provisional; Region: PRK10403 229193011723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193011724 active site 229193011725 phosphorylation site [posttranslational modification] 229193011726 intermolecular recognition site; other site 229193011727 dimerization interface [polypeptide binding]; other site 229193011728 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193011729 DNA binding residues [nucleotide binding] 229193011730 dimerization interface [polypeptide binding]; other site 229193011731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4519 229193011732 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 229193011733 Protein export membrane protein; Region: SecD_SecF; cl14618 229193011734 Protein export membrane protein; Region: SecD_SecF; cl14618 229193011735 probable transmembrane helix predicted by TMHMM2.0 229193011736 probable transmembrane helix predicted by TMHMM2.0 229193011737 probable transmembrane helix predicted by TMHMM2.0 229193011738 probable transmembrane helix predicted by TMHMM2.0 229193011739 probable transmembrane helix predicted by TMHMM2.0 229193011740 probable transmembrane helix predicted by TMHMM2.0 229193011741 probable transmembrane helix predicted by TMHMM2.0 229193011742 probable transmembrane helix predicted by TMHMM2.0 229193011743 probable transmembrane helix predicted by TMHMM2.0 229193011744 probable transmembrane helix predicted by TMHMM2.0 229193011745 probable transmembrane helix predicted by TMHMM2.0 229193011746 probable transmembrane helix predicted by TMHMM2.0 229193011747 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 229193011748 probable transmembrane helix predicted by TMHMM2.0 229193011749 HMMPfam match to entry PF04307 DUF457, E-value 4.1e-24 229193011750 probable transmembrane helix predicted by TMHMM2.0 229193011751 probable transmembrane helix predicted by TMHMM2.0 229193011752 probable transmembrane helix predicted by TMHMM2.0 229193011753 probable transmembrane helix predicted by TMHMM2.0 229193011754 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 229193011755 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 229193011756 Walker A/P-loop; other site 229193011757 ATP binding site [chemical binding]; other site 229193011758 Q-loop/lid; other site 229193011759 ABC transporter signature motif; other site 229193011760 Walker B; other site 229193011761 D-loop; other site 229193011762 H-loop/switch region; other site 229193011763 BlastProDom match to entry PD039360 sp_Q57585_Y121_METJA, E-value 6e-10 229193011764 probable transmembrane helix predicted by TMHMM2.0 229193011765 probable transmembrane helix predicted by TMHMM2.0 229193011766 probable transmembrane helix predicted by TMHMM2.0 229193011767 probable transmembrane helix predicted by TMHMM2.0 229193011768 probable transmembrane helix predicted by TMHMM2.0 229193011769 probable transmembrane helix predicted by TMHMM2.0 229193011770 probable transmembrane helix predicted by TMHMM2.0 229193011771 probable transmembrane helix predicted by TMHMM2.0 229193011772 probable transmembrane helix predicted by TMHMM2.0 229193011773 probable transmembrane helix predicted by TMHMM2.0 229193011774 probable transmembrane helix predicted by TMHMM2.0 229193011775 probable transmembrane helix predicted by TMHMM2.0 229193011776 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 229193011777 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 229193011778 probable transmembrane helix predicted by TMHMM2.0 229193011779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 229193011780 TPR motif; other site 229193011781 Tetratrico peptide repeat; Region: TPR_5; pfam12688 229193011782 binding surface 229193011783 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 229193011784 ArsC family; Region: ArsC; pfam03960 229193011785 putative catalytic residues [active] 229193011786 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 229193011787 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 229193011788 metal binding site [ion binding]; metal-binding site 229193011789 dimer interface [polypeptide binding]; other site 229193011790 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 229193011791 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 229193011792 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 229193011793 probable transmembrane helix predicted by TMHMM2.0 229193011794 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 229193011795 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 229193011796 Helicase; Region: Helicase_RecD; pfam05127 229193011797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 229193011798 Coenzyme A binding pocket [chemical binding]; other site 229193011799 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 229193011800 HMMPfam match to entry PF05127 DUF699, E-value 2.2e-41 229193011801 Predicted membrane protein [Function unknown]; Region: COG2707 229193011802 HMMPfam match to entry PF04284 DUF441, E-value 8.9e-71 229193011803 probable transmembrane helix predicted by TMHMM2.0 229193011804 probable transmembrane helix predicted by TMHMM2.0 229193011805 probable transmembrane helix predicted by TMHMM2.0 229193011806 probable transmembrane helix predicted by TMHMM2.0 229193011807 Predicted metalloprotease [General function prediction only]; Region: COG2321 229193011808 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 229193011809 BlastProDom match to entry PD023842 sp_P76563_P76563_ECOLI, E-value e-123. HMMPfam match to entry PF04228 Zn_peptidase, E-value 6.7e-176 229193011810 probable transmembrane helix predicted by TMHMM2.0 229193011811 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 229193011812 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 229193011813 ATP binding site [chemical binding]; other site 229193011814 active site 229193011815 substrate binding site [chemical binding]; other site 229193011816 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193011817 lipoprotein; Provisional; Region: PRK11679 229193011818 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 229193011819 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 229193011820 dihydrodipicolinate synthase; Region: dapA; TIGR00674 229193011821 dimer interface [polypeptide binding]; other site 229193011822 active site 229193011823 catalytic residue [active] 229193011824 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 229193011825 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 229193011826 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 229193011827 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 229193011828 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 229193011829 catalytic triad [active] 229193011830 probable transmembrane helix predicted by TMHMM2.0 229193011831 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 229193011832 Domain of unknown function DUF20; Region: UPF0118; pfam01594 229193011833 probable transmembrane helix predicted by TMHMM2.0 229193011834 probable transmembrane helix predicted by TMHMM2.0 229193011835 probable transmembrane helix predicted by TMHMM2.0 229193011836 probable transmembrane helix predicted by TMHMM2.0 229193011837 probable transmembrane helix predicted by TMHMM2.0 229193011838 probable transmembrane helix predicted by TMHMM2.0 229193011839 probable transmembrane helix predicted by TMHMM2.0 229193011840 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 229193011841 Peptidase family M48; Region: Peptidase_M48; pfam01435 229193011842 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 229193011843 ArsC family; Region: ArsC; pfam03960 229193011844 catalytic residues [active] 229193011845 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 229193011846 DNA replication initiation factor; Provisional; Region: PRK08084 229193011847 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193011848 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 229193011849 active site 229193011850 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 229193011851 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 229193011852 dimerization interface [polypeptide binding]; other site 229193011853 putative ATP binding site [chemical binding]; other site 229193011854 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 229193011855 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 229193011856 active site 229193011857 substrate binding site [chemical binding]; other site 229193011858 cosubstrate binding site; other site 229193011859 catalytic site [active] 229193011860 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 229193011861 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 229193011862 Contains Protein of unknown function UPF0153 (Interpro|IPR005358, (GO:0005554)) . Contains Protein of unknown function UPF0153 (Interpro|IPR005358, (GO:0005554)) 229193011863 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 229193011864 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 229193011865 Walker A/P-loop; other site 229193011866 ATP binding site [chemical binding]; other site 229193011867 Q-loop/lid; other site 229193011868 ABC transporter signature motif; other site 229193011869 Walker B; other site 229193011870 D-loop; other site 229193011871 H-loop/switch region; other site 229193011872 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 229193011873 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 229193011874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193011875 dimer interface [polypeptide binding]; other site 229193011876 conserved gate region; other site 229193011877 putative PBP binding loops; other site 229193011878 ABC-ATPase subunit interface; other site 229193011879 probable transmembrane helix predicted by TMHMM2.0 229193011880 probable transmembrane helix predicted by TMHMM2.0 229193011881 probable transmembrane helix predicted by TMHMM2.0 229193011882 probable transmembrane helix predicted by TMHMM2.0 229193011883 probable transmembrane helix predicted by TMHMM2.0 229193011884 probable transmembrane helix predicted by TMHMM2.0 229193011885 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 229193011886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193011887 conserved gate region; other site 229193011888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193011889 dimer interface [polypeptide binding]; other site 229193011890 conserved gate region; other site 229193011891 putative PBP binding loops; other site 229193011892 ABC-ATPase subunit interface; other site 229193011893 probable transmembrane helix predicted by TMHMM2.0 229193011894 probable transmembrane helix predicted by TMHMM2.0 229193011895 probable transmembrane helix predicted by TMHMM2.0 229193011896 probable transmembrane helix predicted by TMHMM2.0 229193011897 probable transmembrane helix predicted by TMHMM2.0 229193011898 probable transmembrane helix predicted by TMHMM2.0 229193011899 probable transmembrane helix predicted by TMHMM2.0 229193011900 probable transmembrane helix predicted by TMHMM2.0 229193011901 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 229193011902 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 229193011903 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 229193011904 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 229193011905 putative active site [active] 229193011906 catalytic site [active] 229193011907 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 229193011908 domain interface [polypeptide binding]; other site 229193011909 active site 229193011910 catalytic site [active] 229193011911 exopolyphosphatase; Provisional; Region: PRK10854 229193011912 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 229193011913 nucleotide binding site [chemical binding]; other site 229193011914 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 229193011915 probable transmembrane helix predicted by TMHMM2.0 229193011916 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 229193011917 MgtE intracellular N domain; Region: MgtE_N; smart00924 229193011918 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 229193011919 Divalent cation transporter; Region: MgtE; cl00786 229193011920 probable transmembrane helix predicted by TMHMM2.0 229193011921 probable transmembrane helix predicted by TMHMM2.0 229193011922 probable transmembrane helix predicted by TMHMM2.0 229193011923 putative chaperone; Provisional; Region: PRK11678 229193011924 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 229193011925 nucleotide binding site [chemical binding]; other site 229193011926 putative NEF/HSP70 interaction site [polypeptide binding]; other site 229193011927 SBD interface [polypeptide binding]; other site 229193011928 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 229193011929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193011930 dimer interface [polypeptide binding]; other site 229193011931 conserved gate region; other site 229193011932 putative PBP binding loops; other site 229193011933 ABC-ATPase subunit interface; other site 229193011934 probable transmembrane helix predicted by TMHMM2.0 229193011935 probable transmembrane helix predicted by TMHMM2.0 229193011936 probable transmembrane helix predicted by TMHMM2.0 229193011937 probable transmembrane helix predicted by TMHMM2.0 229193011938 probable transmembrane helix predicted by TMHMM2.0 229193011939 probable transmembrane helix predicted by TMHMM2.0 229193011940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193011941 dimer interface [polypeptide binding]; other site 229193011942 conserved gate region; other site 229193011943 putative PBP binding loops; other site 229193011944 ABC-ATPase subunit interface; other site 229193011945 probable transmembrane helix predicted by TMHMM2.0 229193011946 probable transmembrane helix predicted by TMHMM2.0 229193011947 probable transmembrane helix predicted by TMHMM2.0 229193011948 probable transmembrane helix predicted by TMHMM2.0 229193011949 probable transmembrane helix predicted by TMHMM2.0 229193011950 probable transmembrane helix predicted by TMHMM2.0 229193011951 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 229193011952 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 229193011953 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 229193011954 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 229193011955 inhibitor-cofactor binding pocket; inhibition site 229193011956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193011957 catalytic residue [active] 229193011958 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 229193011959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 229193011960 DNA-binding site [nucleotide binding]; DNA binding site 229193011961 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 229193011962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193011963 homodimer interface [polypeptide binding]; other site 229193011964 catalytic residue [active] 229193011965 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 229193011966 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 229193011967 Walker A/P-loop; other site 229193011968 ATP binding site [chemical binding]; other site 229193011969 Q-loop/lid; other site 229193011970 ABC transporter signature motif; other site 229193011971 Walker B; other site 229193011972 D-loop; other site 229193011973 H-loop/switch region; other site 229193011974 TOBE domain; Region: TOBE_2; pfam08402 229193011975 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 229193011976 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 229193011977 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193011978 probable transmembrane helix predicted by TMHMM2.0 229193011979 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 229193011980 Protein export membrane protein; Region: SecD_SecF; cl14618 229193011981 probable transmembrane helix predicted by TMHMM2.0 229193011982 probable transmembrane helix predicted by TMHMM2.0 229193011983 probable transmembrane helix predicted by TMHMM2.0 229193011984 probable transmembrane helix predicted by TMHMM2.0 229193011985 probable transmembrane helix predicted by TMHMM2.0 229193011986 probable transmembrane helix predicted by TMHMM2.0 229193011987 probable transmembrane helix predicted by TMHMM2.0 229193011988 probable transmembrane helix predicted by TMHMM2.0 229193011989 probable transmembrane helix predicted by TMHMM2.0 229193011990 probable transmembrane helix predicted by TMHMM2.0 229193011991 probable transmembrane helix predicted by TMHMM2.0 229193011992 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 229193011993 Protein export membrane protein; Region: SecD_SecF; cl14618 229193011994 probable transmembrane helix predicted by TMHMM2.0 229193011995 probable transmembrane helix predicted by TMHMM2.0 229193011996 probable transmembrane helix predicted by TMHMM2.0 229193011997 probable transmembrane helix predicted by TMHMM2.0 229193011998 probable transmembrane helix predicted by TMHMM2.0 229193011999 probable transmembrane helix predicted by TMHMM2.0 229193012000 probable transmembrane helix predicted by TMHMM2.0 229193012001 probable transmembrane helix predicted by TMHMM2.0 229193012002 probable transmembrane helix predicted by TMHMM2.0 229193012003 probable transmembrane helix predicted by TMHMM2.0 229193012004 putative transporter; Provisional; Region: PRK10504 229193012005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193012006 putative substrate translocation pore; other site 229193012007 probable transmembrane helix predicted by TMHMM2.0 229193012008 probable transmembrane helix predicted by TMHMM2.0 229193012009 probable transmembrane helix predicted by TMHMM2.0 229193012010 probable transmembrane helix predicted by TMHMM2.0 229193012011 probable transmembrane helix predicted by TMHMM2.0 229193012012 probable transmembrane helix predicted by TMHMM2.0 229193012013 probable transmembrane helix predicted by TMHMM2.0 229193012014 probable transmembrane helix predicted by TMHMM2.0 229193012015 probable transmembrane helix predicted by TMHMM2.0 229193012016 probable transmembrane helix predicted by TMHMM2.0 229193012017 probable transmembrane helix predicted by TMHMM2.0 229193012018 probable transmembrane helix predicted by TMHMM2.0 229193012019 probable transmembrane helix predicted by TMHMM2.0 229193012020 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 229193012021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 229193012022 dimerization interface [polypeptide binding]; other site 229193012023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193012024 dimer interface [polypeptide binding]; other site 229193012025 phosphorylation site [posttranslational modification] 229193012026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193012027 ATP binding site [chemical binding]; other site 229193012028 Mg2+ binding site [ion binding]; other site 229193012029 G-X-G motif; other site 229193012030 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 229193012031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193012032 active site 229193012033 phosphorylation site [posttranslational modification] 229193012034 intermolecular recognition site; other site 229193012035 dimerization interface [polypeptide binding]; other site 229193012036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193012037 DNA binding site [nucleotide binding] 229193012038 Uncharacterized conserved protein [Function unknown]; Region: COG3422 229193012039 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 229193012040 putative protease; Provisional; Region: PRK15452 229193012041 Peptidase family U32; Region: Peptidase_U32; pfam01136 229193012042 lipid kinase; Reviewed; Region: PRK13054 229193012043 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 229193012044 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 229193012045 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 229193012046 substrate binding site [chemical binding]; other site 229193012047 dimer interface [polypeptide binding]; other site 229193012048 ATP binding site [chemical binding]; other site 229193012049 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 229193012050 probable transmembrane helix predicted by TMHMM2.0 229193012051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193012052 MULE transposase domain; Region: MULE; pfam10551 229193012053 probable transmembrane helix predicted by TMHMM2.0 229193012054 probable transmembrane helix predicted by TMHMM2.0 229193012055 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 229193012056 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 229193012057 probable transmembrane helix predicted by TMHMM2.0 229193012058 probable transmembrane helix predicted by TMHMM2.0 229193012059 probable transmembrane helix predicted by TMHMM2.0 229193012060 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 229193012061 probable transmembrane helix predicted by TMHMM2.0 229193012062 probable transmembrane helix predicted by TMHMM2.0 229193012063 probable transmembrane helix predicted by TMHMM2.0 229193012064 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 229193012065 probable transmembrane helix predicted by TMHMM2.0 229193012066 probable transmembrane helix predicted by TMHMM2.0 229193012067 probable transmembrane helix predicted by TMHMM2.0 229193012068 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 229193012069 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193012070 GMP synthase; Reviewed; Region: guaA; PRK00074 229193012071 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 229193012072 AMP/PPi binding site [chemical binding]; other site 229193012073 candidate oxyanion hole; other site 229193012074 catalytic triad [active] 229193012075 potential glutamine specificity residues [chemical binding]; other site 229193012076 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 229193012077 ATP Binding subdomain [chemical binding]; other site 229193012078 Ligand Binding sites [chemical binding]; other site 229193012079 Dimerization subdomain; other site 229193012080 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 229193012081 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 229193012082 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 229193012083 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 229193012084 active site 229193012085 probable transmembrane helix predicted by TMHMM2.0 229193012086 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 229193012087 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 229193012088 generic binding surface II; other site 229193012089 generic binding surface I; other site 229193012090 ProfileScan match to entry PS50322 GLN_RICH, E-value 14.275 229193012091 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 229193012092 Predicted permeases [General function prediction only]; Region: COG0679 229193012093 probable transmembrane helix predicted by TMHMM2.0 229193012094 probable transmembrane helix predicted by TMHMM2.0 229193012095 probable transmembrane helix predicted by TMHMM2.0 229193012096 probable transmembrane helix predicted by TMHMM2.0 229193012097 probable transmembrane helix predicted by TMHMM2.0 229193012098 probable transmembrane helix predicted by TMHMM2.0 229193012099 probable transmembrane helix predicted by TMHMM2.0 229193012100 probable transmembrane helix predicted by TMHMM2.0 229193012101 probable transmembrane helix predicted by TMHMM2.0 229193012102 probable transmembrane helix predicted by TMHMM2.0 229193012103 GTP-binding protein Der; Reviewed; Region: PRK00093 229193012104 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 229193012105 G1 box; other site 229193012106 GTP/Mg2+ binding site [chemical binding]; other site 229193012107 Switch I region; other site 229193012108 G2 box; other site 229193012109 Switch II region; other site 229193012110 G3 box; other site 229193012111 G4 box; other site 229193012112 G5 box; other site 229193012113 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 229193012114 G1 box; other site 229193012115 GTP/Mg2+ binding site [chemical binding]; other site 229193012116 Switch I region; other site 229193012117 G2 box; other site 229193012118 G3 box; other site 229193012119 Switch II region; other site 229193012120 G4 box; other site 229193012121 G5 box; other site 229193012122 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 229193012123 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 229193012124 Trp docking motif [polypeptide binding]; other site 229193012125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 229193012126 probable transmembrane helix predicted by TMHMM2.0 229193012127 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 229193012128 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 229193012129 dimer interface [polypeptide binding]; other site 229193012130 motif 1; other site 229193012131 active site 229193012132 motif 2; other site 229193012133 motif 3; other site 229193012134 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 229193012135 anticodon binding site; other site 229193012136 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 229193012137 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 229193012138 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 229193012139 cytoskeletal protein RodZ; Provisional; Region: PRK10856 229193012140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 229193012141 non-specific DNA binding site [nucleotide binding]; other site 229193012142 salt bridge; other site 229193012143 sequence-specific DNA binding site [nucleotide binding]; other site 229193012144 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 229193012145 probable transmembrane helix predicted by TMHMM2.0 229193012146 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 229193012147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 229193012148 binding surface 229193012149 TPR motif; other site 229193012150 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 229193012151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193012152 FeS/SAM binding site; other site 229193012153 BlastProDom match to entry PD007453 sp_P44665_YFGB_HAEIN, E-value 6e-16 229193012154 HMMPfam match to entry PF04055 Radical_SAM, E-value 3.4e-16 229193012155 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 229193012156 active site 229193012157 multimer interface [polypeptide binding]; other site 229193012158 Protein of unkown function (DUF1881); Region: DUF1881; pfam08964 229193012159 Beta/Gamma crystallin; Region: Crystall; cl02528 229193012160 Beta/Gamma crystallin; Region: Crystall; cl02528 229193012161 Exotoxin A binding; Region: Exotox-A_bind; pfam09101 229193012162 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 229193012163 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 229193012164 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 229193012165 Autotransporter beta-domain; Region: Autotransporter; pfam03797 229193012166 probable transmembrane helix predicted by TMHMM2.0 229193012167 ProfileScan match to entry PS50310 ALA_RICH, E-value 10.746 229193012168 ProfileScan match to entry PS50325 THR_RICH, E-value 10.374 229193012169 probable transmembrane helix predicted by TMHMM2.0 229193012170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193012171 MULE transposase domain; Region: MULE; pfam10551 229193012172 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 229193012173 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 229193012174 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 229193012175 Protein of unknown function (DUF877); Region: DUF877; pfam05943 229193012176 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 229193012177 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 229193012178 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 229193012179 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 229193012180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193012181 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193012182 DNA-binding interface [nucleotide binding]; DNA binding site 229193012183 Integrase core domain; Region: rve; pfam00665 229193012184 transposase/IS protein; Provisional; Region: PRK09183 229193012185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193012186 Walker A motif; other site 229193012187 ATP binding site [chemical binding]; other site 229193012188 Walker B motif; other site 229193012189 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 229193012190 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 229193012191 Na binding site [ion binding]; other site 229193012192 putative substrate binding site [chemical binding]; other site 229193012193 probable transmembrane helix predicted by TMHMM2.0 229193012194 probable transmembrane helix predicted by TMHMM2.0 229193012195 probable transmembrane helix predicted by TMHMM2.0 229193012196 probable transmembrane helix predicted by TMHMM2.0 229193012197 probable transmembrane helix predicted by TMHMM2.0 229193012198 probable transmembrane helix predicted by TMHMM2.0 229193012199 probable transmembrane helix predicted by TMHMM2.0 229193012200 probable transmembrane helix predicted by TMHMM2.0 229193012201 probable transmembrane helix predicted by TMHMM2.0 229193012202 probable transmembrane helix predicted by TMHMM2.0 229193012203 probable transmembrane helix predicted by TMHMM2.0 229193012204 probable transmembrane helix predicted by TMHMM2.0 229193012205 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 229193012206 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 229193012207 active site 229193012208 catalytic site [active] 229193012209 substrate binding site [chemical binding]; other site 229193012210 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 229193012211 RNA/DNA hybrid binding site [nucleotide binding]; other site 229193012212 active site 229193012213 Methyltransferase domain; Region: Methyltransf_11; pfam08241 229193012214 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 229193012215 probable transmembrane helix predicted by TMHMM2.0 229193012216 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 229193012217 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 229193012218 N-acetyl-D-glucosamine binding site [chemical binding]; other site 229193012219 catalytic residue [active] 229193012220 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 229193012221 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 229193012222 hypothetical protein; Provisional; Region: PRK05421 229193012223 putative catalytic site [active] 229193012224 putative phosphate binding site [ion binding]; other site 229193012225 putative metal binding site [ion binding]; other site 229193012226 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 229193012227 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 229193012228 active site 229193012229 catalytic tetrad [active] 229193012230 rRNA operon 229193012231 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 229193012232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193012233 active site 229193012234 motif I; other site 229193012235 motif II; other site 229193012236 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 229193012237 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 229193012238 Walker A/P-loop; other site 229193012239 ATP binding site [chemical binding]; other site 229193012240 Q-loop/lid; other site 229193012241 ABC transporter signature motif; other site 229193012242 Walker B; other site 229193012243 D-loop; other site 229193012244 H-loop/switch region; other site 229193012245 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 229193012246 BlastProDom match to entry PD039360 sp_Q57585_Y121_METJA, E-value 4e-07 229193012247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193012248 dimer interface [polypeptide binding]; other site 229193012249 conserved gate region; other site 229193012250 ABC-ATPase subunit interface; other site 229193012251 probable transmembrane helix predicted by TMHMM2.0 229193012252 probable transmembrane helix predicted by TMHMM2.0 229193012253 probable transmembrane helix predicted by TMHMM2.0 229193012254 probable transmembrane helix predicted by TMHMM2.0 229193012255 probable transmembrane helix predicted by TMHMM2.0 229193012256 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 229193012257 lipoprotein, YaeC family; Region: TIGR00363 229193012258 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 229193012259 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 229193012260 homodimer interaction site [polypeptide binding]; other site 229193012261 cofactor binding site; other site 229193012262 prolyl-tRNA synthetase; Provisional; Region: PRK09194 229193012263 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 229193012264 dimer interface [polypeptide binding]; other site 229193012265 motif 1; other site 229193012266 active site 229193012267 motif 2; other site 229193012268 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 229193012269 putative deacylase active site [active] 229193012270 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 229193012271 active site 229193012272 motif 3; other site 229193012273 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 229193012274 anticodon binding site; other site 229193012275 HMMPfam match to entry PF04073 YbaK, E-value 8.1e-07 229193012276 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 229193012277 NlpE N-terminal domain; Region: NlpE; pfam04170 229193012278 HMMPfam match to entry PF04170 NlpE, E-value 1.9e-51 229193012279 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 229193012280 hypothetical protein; Provisional; Region: PRK09256 229193012281 BlastProDom match to entry PD009420 sp_P40711_YAEJ_ECOLI, E-value 5e-35 229193012282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 229193012283 hypothetical protein; Provisional; Region: PRK04964 229193012284 Rho-binding antiterminator; Provisional; Region: PRK11625 229193012285 Cytochrome c553 [Energy production and conversion]; Region: COG2863 229193012286 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 229193012287 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 229193012288 Ligand Binding Site [chemical binding]; other site 229193012289 TilS substrate binding domain; Region: TilS; pfam09179 229193012290 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 229193012291 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 229193012292 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 229193012293 putative metal binding site [ion binding]; other site 229193012294 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 229193012295 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 229193012296 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 229193012297 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 229193012298 putative active site [active] 229193012299 putative PHP Thumb interface [polypeptide binding]; other site 229193012300 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 229193012301 generic binding surface II; other site 229193012302 generic binding surface I; other site 229193012303 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 229193012304 RNA/DNA hybrid binding site [nucleotide binding]; other site 229193012305 active site 229193012306 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 229193012307 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 229193012308 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 229193012309 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 229193012310 active site 229193012311 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 229193012312 BlastProDom match to entry PD005671 sp_Q9HXY7_FABZ_PSEAE, E-value 7e-13 229193012313 BlastProDom match to entry PD005671 sp_P32205_FABZ_YEREN, E-value 5e-58 229193012314 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 229193012315 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 229193012316 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 229193012317 trimer interface [polypeptide binding]; other site 229193012318 active site 229193012319 UDP-GlcNAc binding site [chemical binding]; other site 229193012320 lipid binding site [chemical binding]; lipid-binding site 229193012321 HMMPfam match to entry PF04613 LpxD, E-value 1e-49 229193012322 periplasmic chaperone; Provisional; Region: PRK10780 229193012323 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 229193012324 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 229193012325 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 229193012326 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 229193012327 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 229193012328 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 229193012329 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 229193012330 Surface antigen; Region: Bac_surface_Ag; pfam01103 229193012331 probable transmembrane helix predicted by TMHMM2.0 229193012332 zinc metallopeptidase RseP; Provisional; Region: PRK10779 229193012333 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 229193012334 active site 229193012335 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 229193012336 protein binding site [polypeptide binding]; other site 229193012337 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 229193012338 protein binding site [polypeptide binding]; other site 229193012339 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 229193012340 putative substrate binding region [chemical binding]; other site 229193012341 probable transmembrane helix predicted by TMHMM2.0 229193012342 probable transmembrane helix predicted by TMHMM2.0 229193012343 probable transmembrane helix predicted by TMHMM2.0 229193012344 probable transmembrane helix predicted by TMHMM2.0 229193012345 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 229193012346 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 229193012347 probable transmembrane helix predicted by TMHMM2.0 229193012348 probable transmembrane helix predicted by TMHMM2.0 229193012349 probable transmembrane helix predicted by TMHMM2.0 229193012350 probable transmembrane helix predicted by TMHMM2.0 229193012351 probable transmembrane helix predicted by TMHMM2.0 229193012352 probable transmembrane helix predicted by TMHMM2.0 229193012353 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 229193012354 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 229193012355 catalytic residue [active] 229193012356 putative FPP diphosphate binding site; other site 229193012357 putative FPP binding hydrophobic cleft; other site 229193012358 dimer interface [polypeptide binding]; other site 229193012359 putative IPP diphosphate binding site; other site 229193012360 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 229193012361 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 229193012362 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 229193012363 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 229193012364 ribosome recycling factor; Reviewed; Region: frr; PRK00083 229193012365 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 229193012366 hinge region; other site 229193012367 BlastProDom match to entry PD004103 sp_P16174_RRF_ECOLI, E-value 3e-75 229193012368 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 229193012369 putative nucleotide binding site [chemical binding]; other site 229193012370 uridine monophosphate binding site [chemical binding]; other site 229193012371 homohexameric interface [polypeptide binding]; other site 229193012372 elongation factor Ts; Provisional; Region: tsf; PRK09377 229193012373 UBA/TS-N domain; Region: UBA; pfam00627 229193012374 Elongation factor TS; Region: EF_TS; pfam00889 229193012375 Elongation factor TS; Region: EF_TS; pfam00889 229193012376 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 229193012377 rRNA interaction site [nucleotide binding]; other site 229193012378 S8 interaction site; other site 229193012379 putative laminin-1 binding site; other site 229193012380 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 229193012381 active site 229193012382 PII uridylyl-transferase; Provisional; Region: PRK05007 229193012383 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 229193012384 metal binding triad; other site 229193012385 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 229193012386 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 229193012387 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 229193012388 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 229193012389 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 229193012390 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 229193012391 trimer interface [polypeptide binding]; other site 229193012392 active site 229193012393 substrate binding site [chemical binding]; other site 229193012394 CoA binding site [chemical binding]; other site 229193012395 hypothetical protein; Provisional; Region: PRK13677 229193012396 flavodoxin; Provisional; Region: PRK08105 229193012397 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 229193012398 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 229193012399 probable active site [active] 229193012400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 229193012401 HMMPfam match to entry PF04287 DUF446, E-value 2.2e-44 229193012402 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193012403 SecY interacting protein Syd; Provisional; Region: PRK04968 229193012404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 229193012405 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 229193012406 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 229193012407 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 229193012408 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 229193012409 flap endonuclease-like protein; Provisional; Region: PRK09482 229193012410 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 229193012411 active site 229193012412 metal binding site 1 [ion binding]; metal-binding site 229193012413 putative 5' ssDNA interaction site; other site 229193012414 metal binding site 3; metal-binding site 229193012415 metal binding site 2 [ion binding]; metal-binding site 229193012416 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 229193012417 putative DNA binding site [nucleotide binding]; other site 229193012418 putative metal binding site [ion binding]; other site 229193012419 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 229193012420 FtsJ-like methyltransferase; Region: FtsJ; cl17430 229193012421 hypothetical protein; Provisional; Region: PRK10873 229193012422 probable transmembrane helix predicted by TMHMM2.0 229193012423 probable transmembrane helix predicted by TMHMM2.0 229193012424 probable transmembrane helix predicted by TMHMM2.0 229193012425 probable transmembrane helix predicted by TMHMM2.0 229193012426 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 229193012427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193012428 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 229193012429 dimerization interface [polypeptide binding]; other site 229193012430 substrate binding pocket [chemical binding]; other site 229193012431 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 229193012432 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 229193012433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193012434 catalytic residue [active] 229193012435 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 229193012436 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 229193012437 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 229193012438 putative ATP binding site [chemical binding]; other site 229193012439 putative substrate interface [chemical binding]; other site 229193012440 probable transmembrane helix predicted by TMHMM2.0 229193012441 murein transglycosylase A; Provisional; Region: mltA; PRK11162 229193012442 MltA specific insert domain; Region: MltA; smart00925 229193012443 3D domain; Region: 3D; pfam06725 229193012444 AMIN domain; Region: AMIN; pfam11741 229193012445 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 229193012446 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 229193012447 active site 229193012448 metal binding site [ion binding]; metal-binding site 229193012449 BlastProDom match to entry PD002984 sp_Q46929_AMIC_ECOLI, E-value 5e-19 229193012450 BlastProDom match to entry PD002984 sp_Q46929_AMIC_ECOLI, E-value 6e-60 229193012451 N-acetylglutamate synthase; Validated; Region: PRK05279 229193012452 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 229193012453 putative feedback inhibition sensing region; other site 229193012454 putative nucleotide binding site [chemical binding]; other site 229193012455 putative substrate binding site [chemical binding]; other site 229193012456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 229193012457 Coenzyme A binding pocket [chemical binding]; other site 229193012458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193012459 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193012460 DNA-binding interface [nucleotide binding]; DNA binding site 229193012461 Integrase core domain; Region: rve; pfam00665 229193012462 transposase/IS protein; Provisional; Region: PRK09183 229193012463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193012464 Walker A motif; other site 229193012465 ATP binding site [chemical binding]; other site 229193012466 Walker B motif; other site 229193012467 Lyase, N terminal; Region: Lyase_N; pfam09092 229193012468 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 229193012469 substrate binding site [chemical binding]; other site 229193012470 catalytic residues [active] 229193012471 Autotransporter beta-domain; Region: Autotransporter; pfam03797 229193012472 probable transmembrane helix predicted by TMHMM2.0 229193012473 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 229193012474 active site clefts [active] 229193012475 zinc binding site [ion binding]; other site 229193012476 dimer interface [polypeptide binding]; other site 229193012477 probable transmembrane helix predicted by TMHMM2.0 229193012478 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 229193012479 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 229193012480 probable transmembrane helix predicted by TMHMM2.0 229193012481 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 229193012482 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 229193012483 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 229193012484 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 229193012485 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 229193012486 probable transmembrane helix predicted by TMHMM2.0 229193012487 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 229193012488 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 229193012489 Walker A motif; other site 229193012490 ATP binding site [chemical binding]; other site 229193012491 Walker B motif; other site 229193012492 type II secretion system protein F; Region: GspF; TIGR02120 229193012493 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 229193012494 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 229193012495 probable transmembrane helix predicted by TMHMM2.0 229193012496 probable transmembrane helix predicted by TMHMM2.0 229193012497 probable transmembrane helix predicted by TMHMM2.0 229193012498 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 229193012499 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 229193012500 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 229193012501 probable transmembrane helix predicted by TMHMM2.0 229193012502 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 229193012503 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 229193012504 probable transmembrane helix predicted by TMHMM2.0 229193012505 type II secretion system protein I; Region: gspI; TIGR01707 229193012506 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 229193012507 probable transmembrane helix predicted by TMHMM2.0 229193012508 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 229193012509 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 229193012510 probable transmembrane helix predicted by TMHMM2.0 229193012511 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 229193012512 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 229193012513 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 229193012514 GspL periplasmic domain; Region: GspL_C; pfam12693 229193012515 HMMPfam match to entry PF05134 GspL, E-value 5.3e-07 229193012516 probable transmembrane helix predicted by TMHMM2.0 229193012517 probable transmembrane helix predicted by TMHMM2.0 229193012518 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 229193012519 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 229193012520 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 229193012521 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; pfam09691 229193012522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193012523 MULE transposase domain; Region: MULE; pfam10551 229193012524 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 229193012525 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 229193012526 dimer interface [polypeptide binding]; other site 229193012527 ligand binding site [chemical binding]; other site 229193012528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 229193012529 dimerization interface [polypeptide binding]; other site 229193012530 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 229193012531 dimer interface [polypeptide binding]; other site 229193012532 putative CheW interface [polypeptide binding]; other site 229193012533 probable transmembrane helix predicted by TMHMM2.0 229193012534 probable transmembrane helix predicted by TMHMM2.0 229193012535 BlastProDom match to entry PD000571 sp_P07018_MCP4_ECOLI, E-value 1e-10 229193012536 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 229193012537 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 229193012538 catalytic residues [active] 229193012539 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 229193012540 transcriptional activator TtdR; Provisional; Region: PRK09801 229193012541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193012542 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 229193012543 putative effector binding pocket; other site 229193012544 dimerization interface [polypeptide binding]; other site 229193012545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193012546 putative substrate translocation pore; other site 229193012547 Major Facilitator Superfamily; Region: MFS_1; pfam07690 229193012548 probable transmembrane helix predicted by TMHMM2.0 229193012549 probable transmembrane helix predicted by TMHMM2.0 229193012550 probable transmembrane helix predicted by TMHMM2.0 229193012551 probable transmembrane helix predicted by TMHMM2.0 229193012552 probable transmembrane helix predicted by TMHMM2.0 229193012553 probable transmembrane helix predicted by TMHMM2.0 229193012554 probable transmembrane helix predicted by TMHMM2.0 229193012555 probable transmembrane helix predicted by TMHMM2.0 229193012556 probable transmembrane helix predicted by TMHMM2.0 229193012557 probable transmembrane helix predicted by TMHMM2.0 229193012558 probable transmembrane helix predicted by TMHMM2.0 229193012559 probable transmembrane helix predicted by TMHMM2.0 229193012560 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 229193012561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193012562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 229193012563 dimerization interface [polypeptide binding]; other site 229193012564 diaminopimelate decarboxylase; Provisional; Region: PRK11165 229193012565 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 229193012566 active site 229193012567 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 229193012568 substrate binding site [chemical binding]; other site 229193012569 catalytic residues [active] 229193012570 dimer interface [polypeptide binding]; other site 229193012571 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 229193012572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193012573 DNA binding site [nucleotide binding] 229193012574 domain linker motif; other site 229193012575 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 229193012576 dimerization interface (closed form) [polypeptide binding]; other site 229193012577 ligand binding site [chemical binding]; other site 229193012578 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 229193012579 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 229193012580 molybdopterin cofactor binding site [chemical binding]; other site 229193012581 substrate binding site [chemical binding]; other site 229193012582 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 229193012583 molybdopterin cofactor binding site; other site 229193012584 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 229193012585 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 229193012586 putative acyl-acceptor binding pocket; other site 229193012587 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 229193012588 acyl-activating enzyme (AAE) consensus motif; other site 229193012589 putative AMP binding site [chemical binding]; other site 229193012590 lysophospholipid transporter LplT; Provisional; Region: PRK11195 229193012591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193012592 putative substrate translocation pore; other site 229193012593 probable transmembrane helix predicted by TMHMM2.0 229193012594 probable transmembrane helix predicted by TMHMM2.0 229193012595 probable transmembrane helix predicted by TMHMM2.0 229193012596 probable transmembrane helix predicted by TMHMM2.0 229193012597 probable transmembrane helix predicted by TMHMM2.0 229193012598 probable transmembrane helix predicted by TMHMM2.0 229193012599 probable transmembrane helix predicted by TMHMM2.0 229193012600 probable transmembrane helix predicted by TMHMM2.0 229193012601 probable transmembrane helix predicted by TMHMM2.0 229193012602 probable transmembrane helix predicted by TMHMM2.0 229193012603 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 229193012604 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 229193012605 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 229193012606 active site 229193012607 catalytic tetrad [active] 229193012608 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 229193012609 putative DNA-binding cleft [nucleotide binding]; other site 229193012610 putative DNA clevage site; other site 229193012611 molecular lever; other site 229193012612 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 229193012613 putative active site [active] 229193012614 Ap4A binding site [chemical binding]; other site 229193012615 nudix motif; other site 229193012616 putative metal binding site [ion binding]; other site 229193012617 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 229193012618 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 229193012619 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 229193012620 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 229193012621 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 229193012622 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 229193012623 probable transmembrane helix predicted by TMHMM2.0 229193012624 probable transmembrane helix predicted by TMHMM2.0 229193012625 probable transmembrane helix predicted by TMHMM2.0 229193012626 probable transmembrane helix predicted by TMHMM2.0 229193012627 probable transmembrane helix predicted by TMHMM2.0 229193012628 probable transmembrane helix predicted by TMHMM2.0 229193012629 probable transmembrane helix predicted by TMHMM2.0 229193012630 thymidylate synthase; Reviewed; Region: thyA; PRK01827 229193012631 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 229193012632 dimerization interface [polypeptide binding]; other site 229193012633 active site 229193012634 hypothetical protein; Provisional; Region: PRK10506 229193012635 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 229193012636 probable transmembrane helix predicted by TMHMM2.0 229193012637 hypothetical protein; Provisional; Region: PRK10557 229193012638 Protein of unknown function (DUF2509); Region: DUF2509; pfam10713 229193012639 probable transmembrane helix predicted by TMHMM2.0 229193012640 hypothetical protein; Provisional; Region: PRK10332 229193012641 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 229193012642 probable transmembrane helix predicted by TMHMM2.0 229193012643 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 229193012644 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 229193012645 protease3; Provisional; Region: PRK15101 229193012646 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 229193012647 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 229193012648 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 229193012649 probable transmembrane helix predicted by TMHMM2.0 229193012650 HMMPfam match to entry PF05193 Peptidase_M16_C, E-value 4.7e-26 229193012651 HMMPfam match to entry PF05193 Peptidase_M16_C, E-value 3.9e-13 229193012652 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 229193012653 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 229193012654 AAA domain; Region: AAA_30; pfam13604 229193012655 Family description; Region: UvrD_C_2; pfam13538 229193012656 transposase/IS protein; Provisional; Region: PRK09183 229193012657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193012658 Walker A motif; other site 229193012659 ATP binding site [chemical binding]; other site 229193012660 Walker B motif; other site 229193012661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193012662 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193012663 DNA-binding interface [nucleotide binding]; DNA binding site 229193012664 Integrase core domain; Region: rve; pfam00665 229193012665 Predicted membrane protein [Function unknown]; Region: COG2259 229193012666 probable transmembrane helix predicted by TMHMM2.0 229193012667 HMMPfam match to entry PF04173 DoxD, E-value 3.6e-33 229193012668 probable transmembrane helix predicted by TMHMM2.0 229193012669 probable transmembrane helix predicted by TMHMM2.0 229193012670 probable transmembrane helix predicted by TMHMM2.0 229193012671 YqjK-like protein; Region: YqjK; pfam13997 229193012672 Predicted membrane protein [Function unknown]; Region: COG5393 229193012673 probable transmembrane helix predicted by TMHMM2.0 229193012674 probable transmembrane helix predicted by TMHMM2.0 229193012675 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 229193012676 probable transmembrane helix predicted by TMHMM2.0 229193012677 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 229193012678 ProfileScan match to entry PS50322 GLN_RICH, E-value 8.882 229193012679 probable transmembrane helix predicted by TMHMM2.0 229193012680 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 229193012681 probable transmembrane helix predicted by TMHMM2.0 229193012682 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 229193012683 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 229193012684 probable transmembrane helix predicted by TMHMM2.0 229193012685 probable transmembrane helix predicted by TMHMM2.0 229193012686 probable transmembrane helix predicted by TMHMM2.0 229193012687 probable transmembrane helix predicted by TMHMM2.0 229193012688 probable transmembrane helix predicted by TMHMM2.0 229193012689 probable transmembrane helix predicted by TMHMM2.0 229193012690 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 229193012691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 229193012692 DNA-binding site [nucleotide binding]; DNA binding site 229193012693 FCD domain; Region: FCD; pfam07729 229193012694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193012695 D-galactonate transporter; Region: 2A0114; TIGR00893 229193012696 putative substrate translocation pore; other site 229193012697 probable transmembrane helix predicted by TMHMM2.0 229193012698 probable transmembrane helix predicted by TMHMM2.0 229193012699 probable transmembrane helix predicted by TMHMM2.0 229193012700 probable transmembrane helix predicted by TMHMM2.0 229193012701 probable transmembrane helix predicted by TMHMM2.0 229193012702 probable transmembrane helix predicted by TMHMM2.0 229193012703 probable transmembrane helix predicted by TMHMM2.0 229193012704 probable transmembrane helix predicted by TMHMM2.0 229193012705 probable transmembrane helix predicted by TMHMM2.0 229193012706 probable transmembrane helix predicted by TMHMM2.0 229193012707 probable transmembrane helix predicted by TMHMM2.0 229193012708 probable transmembrane helix predicted by TMHMM2.0 229193012709 Glucuronate isomerase; Region: UxaC; pfam02614 229193012710 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 229193012711 altronate oxidoreductase; Provisional; Region: PRK03643 229193012712 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 229193012713 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 229193012714 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 229193012715 galactarate dehydratase; Region: galactar-dH20; TIGR03248 229193012716 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 229193012717 HMMPfam match to entry PF04292 GD_AH_N, E-value 3.8e-34 229193012718 HMMPfam match to entry PF04295 GD_AH_C, E-value 3.4e-250 229193012719 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 229193012720 probable transmembrane helix predicted by TMHMM2.0 229193012721 probable transmembrane helix predicted by TMHMM2.0 229193012722 probable transmembrane helix predicted by TMHMM2.0 229193012723 probable transmembrane helix predicted by TMHMM2.0 229193012724 probable transmembrane helix predicted by TMHMM2.0 229193012725 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193012726 serine/threonine transporter SstT; Provisional; Region: PRK13628 229193012727 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 229193012728 probable transmembrane helix predicted by TMHMM2.0 229193012729 probable transmembrane helix predicted by TMHMM2.0 229193012730 probable transmembrane helix predicted by TMHMM2.0 229193012731 probable transmembrane helix predicted by TMHMM2.0 229193012732 probable transmembrane helix predicted by TMHMM2.0 229193012733 probable transmembrane helix predicted by TMHMM2.0 229193012734 probable transmembrane helix predicted by TMHMM2.0 229193012735 probable transmembrane helix predicted by TMHMM2.0 229193012736 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 229193012737 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 229193012738 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 229193012739 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 229193012740 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 229193012741 Autotransporter beta-domain; Region: Autotransporter; pfam03797 229193012742 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 229193012743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193012744 S-adenosylmethionine binding site [chemical binding]; other site 229193012745 HMMPfam match to entry PF05175 MTS, E-value 1.1e-17 229193012746 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 229193012747 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 229193012748 active site 229193012749 FMN binding site [chemical binding]; other site 229193012750 2,4-decadienoyl-CoA binding site; other site 229193012751 catalytic residue [active] 229193012752 4Fe-4S cluster binding site [ion binding]; other site 229193012753 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 229193012754 acid-resistance membrane protein; Provisional; Region: PRK10209 229193012755 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 229193012756 probable transmembrane helix predicted by TMHMM2.0 229193012757 probable transmembrane helix predicted by TMHMM2.0 229193012758 probable transmembrane helix predicted by TMHMM2.0 229193012759 probable transmembrane helix predicted by TMHMM2.0 229193012760 probable transmembrane helix predicted by TMHMM2.0 229193012761 probable transmembrane helix predicted by TMHMM2.0 229193012762 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 229193012763 substrate binding site [chemical binding]; other site 229193012764 activation loop (A-loop); other site 229193012765 Protein phosphatase 2C; Region: PP2C_2; pfam13672 229193012766 Contains Von Willebrand factor, type A (Interpro|IPR002035) 229193012767 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 229193012768 metal ion-dependent adhesion site (MIDAS); other site 229193012769 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 229193012770 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 229193012771 putative metal binding site [ion binding]; other site 229193012772 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 229193012773 metal ion-dependent adhesion site (MIDAS); other site 229193012774 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 229193012775 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 229193012776 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 229193012777 haemagglutination activity domain; Region: Haemagg_act; pfam05860 229193012778 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 229193012779 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 229193012780 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 229193012781 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 229193012782 ProfileScan match to entry PS50310 ALA_RICH, E-value 10.050 229193012783 V-type ATP synthase subunit E; Provisional; Region: PRK02292 229193012784 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 229193012785 Autotransporter beta-domain; Region: Autotransporter; smart00869 229193012786 Putative glucoamylase; Region: Glycoamylase; pfam10091 229193012787 probable transmembrane helix predicted by TMHMM2.0 229193012788 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 229193012789 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 229193012790 Walker A/P-loop; other site 229193012791 ATP binding site [chemical binding]; other site 229193012792 Q-loop/lid; other site 229193012793 ABC transporter signature motif; other site 229193012794 Walker B; other site 229193012795 D-loop; other site 229193012796 H-loop/switch region; other site 229193012797 TOBE domain; Region: TOBE_2; pfam08402 229193012798 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 229193012799 Transcriptional regulators [Transcription]; Region: PurR; COG1609 229193012800 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193012801 DNA binding site [nucleotide binding] 229193012802 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 229193012803 ligand binding site [chemical binding]; other site 229193012804 dimerization interface [polypeptide binding]; other site 229193012805 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 229193012806 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 229193012807 probable transmembrane helix predicted by TMHMM2.0 229193012808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193012809 dimer interface [polypeptide binding]; other site 229193012810 conserved gate region; other site 229193012811 putative PBP binding loops; other site 229193012812 ABC-ATPase subunit interface; other site 229193012813 probable transmembrane helix predicted by TMHMM2.0 229193012814 probable transmembrane helix predicted by TMHMM2.0 229193012815 probable transmembrane helix predicted by TMHMM2.0 229193012816 probable transmembrane helix predicted by TMHMM2.0 229193012817 probable transmembrane helix predicted by TMHMM2.0 229193012818 probable transmembrane helix predicted by TMHMM2.0 229193012819 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 229193012820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193012821 dimer interface [polypeptide binding]; other site 229193012822 conserved gate region; other site 229193012823 putative PBP binding loops; other site 229193012824 ABC-ATPase subunit interface; other site 229193012825 probable transmembrane helix predicted by TMHMM2.0 229193012826 probable transmembrane helix predicted by TMHMM2.0 229193012827 probable transmembrane helix predicted by TMHMM2.0 229193012828 probable transmembrane helix predicted by TMHMM2.0 229193012829 probable transmembrane helix predicted by TMHMM2.0 229193012830 probable transmembrane helix predicted by TMHMM2.0 229193012831 probable transmembrane helix predicted by TMHMM2.0 229193012832 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 229193012833 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 229193012834 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 229193012835 Outer membrane efflux protein; Region: OEP; pfam02321 229193012836 Outer membrane efflux protein; Region: OEP; pfam02321 229193012837 probable transmembrane helix predicted by TMHMM2.0 229193012838 Predicted membrane protein [Function unknown]; Region: COG1289 229193012839 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 229193012840 probable transmembrane helix predicted by TMHMM2.0 229193012841 probable transmembrane helix predicted by TMHMM2.0 229193012842 probable transmembrane helix predicted by TMHMM2.0 229193012843 probable transmembrane helix predicted by TMHMM2.0 229193012844 probable transmembrane helix predicted by TMHMM2.0 229193012845 probable transmembrane helix predicted by TMHMM2.0 229193012846 probable transmembrane helix predicted by TMHMM2.0 229193012847 probable transmembrane helix predicted by TMHMM2.0 229193012848 probable transmembrane helix predicted by TMHMM2.0 229193012849 multidrug resistance protein MdtN; Provisional; Region: PRK10476 229193012850 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 229193012851 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193012852 probable transmembrane helix predicted by TMHMM2.0 229193012853 probable transmembrane helix predicted by TMHMM2.0 229193012854 probable transmembrane helix predicted by TMHMM2.0 229193012855 probable transmembrane helix predicted by TMHMM2.0 229193012856 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 229193012857 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 229193012858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193012859 homodimer interface [polypeptide binding]; other site 229193012860 catalytic residue [active] 229193012861 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 229193012862 probable transmembrane helix predicted by TMHMM2.0 229193012863 probable transmembrane helix predicted by TMHMM2.0 229193012864 probable transmembrane helix predicted by TMHMM2.0 229193012865 probable transmembrane helix predicted by TMHMM2.0 229193012866 probable transmembrane helix predicted by TMHMM2.0 229193012867 probable transmembrane helix predicted by TMHMM2.0 229193012868 probable transmembrane helix predicted by TMHMM2.0 229193012869 probable transmembrane helix predicted by TMHMM2.0 229193012870 probable transmembrane helix predicted by TMHMM2.0 229193012871 probable transmembrane helix predicted by TMHMM2.0 229193012872 probable transmembrane helix predicted by TMHMM2.0 229193012873 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 229193012874 putative hydrophobic ligand binding site [chemical binding]; other site 229193012875 protein interface [polypeptide binding]; other site 229193012876 gate; other site 229193012877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 229193012878 YheO-like PAS domain; Region: PAS_6; pfam08348 229193012879 HTH domain; Region: HTH_22; pfam13309 229193012880 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 229193012881 homotrimer interaction site [polypeptide binding]; other site 229193012882 putative active site [active] 229193012883 BlastProDom match to entry PD002429 sp_Q9KGJ8_Q9KGJ8_BACHD, E-value 9e-19 229193012884 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 229193012885 homotrimer interaction site [polypeptide binding]; other site 229193012886 putative active site [active] 229193012887 putative monooxygenase; Provisional; Region: PRK11118 229193012888 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 229193012889 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 229193012890 catalytic residues [active] 229193012891 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193012892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193012893 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 229193012894 putative effector binding pocket; other site 229193012895 putative dimerization interface [polypeptide binding]; other site 229193012896 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 229193012897 active site 229193012898 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193012899 MULE transposase domain; Region: MULE; pfam10551 229193012900 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 229193012901 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 229193012902 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 229193012903 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 229193012904 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 229193012905 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 229193012906 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 229193012907 DNA binding residues [nucleotide binding] 229193012908 HMMPfam match to entry PF04545 sigma70_r4, E-value 1.8e-21 229193012909 HMMPfam match to entry PF04539 sigma70_r3, E-value 2.8e-39 229193012910 HMMPfam match to entry PF04542 sigma70_r2, E-value 1.7e-27 229193012911 HMMPfam match to entry PF04546 sigma70_ner, E-value 2.6e-117 229193012912 ProfileScan match to entry PS50312 ASP_RICH, E-value 8.562 229193012913 HMMPfam match to entry PF03979 sigma70_r1_1, E-value 5.1e-43 229193012914 DNA primase; Validated; Region: dnaG; PRK05667 229193012915 CHC2 zinc finger; Region: zf-CHC2; pfam01807 229193012916 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 229193012917 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 229193012918 active site 229193012919 metal binding site [ion binding]; metal-binding site 229193012920 interdomain interaction site; other site 229193012921 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 229193012922 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 229193012923 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 229193012924 UGMP family protein; Validated; Region: PRK09604 229193012925 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 229193012926 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 229193012927 probable transmembrane helix predicted by TMHMM2.0 229193012928 probable transmembrane helix predicted by TMHMM2.0 229193012929 probable transmembrane helix predicted by TMHMM2.0 229193012930 probable transmembrane helix predicted by TMHMM2.0 229193012931 probable transmembrane helix predicted by TMHMM2.0 229193012932 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 229193012933 active site 229193012934 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 229193012935 probable transmembrane helix predicted by TMHMM2.0 229193012936 probable transmembrane helix predicted by TMHMM2.0 229193012937 probable transmembrane helix predicted by TMHMM2.0 229193012938 probable transmembrane helix predicted by TMHMM2.0 229193012939 probable transmembrane helix predicted by TMHMM2.0 229193012940 probable transmembrane helix predicted by TMHMM2.0 229193012941 probable transmembrane helix predicted by TMHMM2.0 229193012942 probable transmembrane helix predicted by TMHMM2.0 229193012943 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 229193012944 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 229193012945 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 229193012946 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 229193012947 Zn2+ binding site [ion binding]; other site 229193012948 Mg2+ binding site [ion binding]; other site 229193012949 SH3 domain-containing protein; Provisional; Region: PRK10884 229193012950 Bacterial SH3 domain homologues; Region: SH3b; smart00287 229193012951 probable transmembrane helix predicted by TMHMM2.0 229193012952 Uncharacterized conserved protein [Function unknown]; Region: COG3025 229193012953 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 229193012954 putative active site [active] 229193012955 putative metal binding residues [ion binding]; other site 229193012956 signature motif; other site 229193012957 putative triphosphate binding site [ion binding]; other site 229193012958 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 229193012959 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 229193012960 metal binding triad; other site 229193012961 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 229193012962 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 229193012963 metal binding triad; other site 229193012964 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 229193012965 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 229193012966 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 229193012967 putative ribose interaction site [chemical binding]; other site 229193012968 putative ADP binding site [chemical binding]; other site 229193012969 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 229193012970 active site 229193012971 nucleotide binding site [chemical binding]; other site 229193012972 HIGH motif; other site 229193012973 KMSKS motif; other site 229193012974 BlastProDom match to entry PD023180 sp_Q9RFY7_Q9RFY7_BBBBB, E-value 6e-32 229193012975 BlastProDom match to entry PD001938 sp_Q9RFY7_Q9RFY7_BBBBB, E-value 7e-63 229193012976 putative transporter; Provisional; Region: PRK11021 229193012977 probable transmembrane helix predicted by TMHMM2.0 229193012978 probable transmembrane helix predicted by TMHMM2.0 229193012979 probable transmembrane helix predicted by TMHMM2.0 229193012980 probable transmembrane helix predicted by TMHMM2.0 229193012981 probable transmembrane helix predicted by TMHMM2.0 229193012982 probable transmembrane helix predicted by TMHMM2.0 229193012983 probable transmembrane helix predicted by TMHMM2.0 229193012984 probable transmembrane helix predicted by TMHMM2.0 229193012985 probable transmembrane helix predicted by TMHMM2.0 229193012986 probable transmembrane helix predicted by TMHMM2.0 229193012987 probable transmembrane helix predicted by TMHMM2.0 229193012988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 229193012989 HMMPfam match to entry PF04380 DUF526, E-value 2.3e-43 229193012990 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 229193012991 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 229193012992 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 229193012993 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 229193012994 putative active site [active] 229193012995 metal binding site [ion binding]; metal-binding site 229193012996 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 229193012997 hypothetical protein; Provisional; Region: PRK11653 229193012998 probable transmembrane helix predicted by TMHMM2.0 229193012999 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 229193013000 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 229193013001 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 229193013002 dimer interface [polypeptide binding]; other site 229193013003 ADP-ribose binding site [chemical binding]; other site 229193013004 active site 229193013005 nudix motif; other site 229193013006 metal binding site [ion binding]; metal-binding site 229193013007 putative dehydrogenase; Provisional; Region: PRK11039 229193013008 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 229193013009 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 229193013010 active site 229193013011 metal binding site [ion binding]; metal-binding site 229193013012 hexamer interface [polypeptide binding]; other site 229193013013 esterase YqiA; Provisional; Region: PRK11071 229193013014 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 229193013015 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 229193013016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193013017 ATP binding site [chemical binding]; other site 229193013018 Mg2+ binding site [ion binding]; other site 229193013019 G-X-G motif; other site 229193013020 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 229193013021 anchoring element; other site 229193013022 dimer interface [polypeptide binding]; other site 229193013023 ATP binding site [chemical binding]; other site 229193013024 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 229193013025 active site 229193013026 metal binding site [ion binding]; metal-binding site 229193013027 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 229193013028 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193013029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193013030 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 229193013031 dimerization interface [polypeptide binding]; other site 229193013032 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 229193013033 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 229193013034 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 229193013035 CAP-like domain; other site 229193013036 active site 229193013037 primary dimer interface [polypeptide binding]; other site 229193013038 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 229193013039 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 229193013040 putative acyl-acceptor binding pocket; other site 229193013041 probable transmembrane helix predicted by TMHMM2.0 229193013042 FtsI repressor; Provisional; Region: PRK10883 229193013043 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 229193013044 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 229193013045 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 229193013046 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 229193013047 active site 229193013048 catalytic tetrad [active] 229193013049 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 229193013050 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 229193013051 dimer interface [polypeptide binding]; other site 229193013052 active site 229193013053 metal binding site [ion binding]; metal-binding site 229193013054 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 229193013055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193013056 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 229193013057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193013058 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 229193013059 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 229193013060 probable transmembrane helix predicted by TMHMM2.0 229193013061 probable transmembrane helix predicted by TMHMM2.0 229193013062 probable transmembrane helix predicted by TMHMM2.0 229193013063 probable transmembrane helix predicted by TMHMM2.0 229193013064 probable transmembrane helix predicted by TMHMM2.0 229193013065 cystathionine beta-lyase; Provisional; Region: PRK08114 229193013066 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 229193013067 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193013068 catalytic residue [active] 229193013069 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 229193013070 probable transmembrane helix predicted by TMHMM2.0 229193013071 probable transmembrane helix predicted by TMHMM2.0 229193013072 BlastProDom match to entry PD003317 sp_Q05605_EXBB_PSEPU, E-value 3e-22 229193013073 probable transmembrane helix predicted by TMHMM2.0 229193013074 probable transmembrane helix predicted by TMHMM2.0 229193013075 biopolymer transport protein ExbD; Provisional; Region: PRK11267 229193013076 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 229193013077 probable transmembrane helix predicted by TMHMM2.0 229193013078 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 229193013079 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 229193013080 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 229193013081 metal ion-dependent adhesion site (MIDAS); other site 229193013082 probable transmembrane helix predicted by TMHMM2.0 229193013083 probable transmembrane helix predicted by TMHMM2.0 229193013084 probable transmembrane helix predicted by TMHMM2.0 229193013085 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 229193013086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 229193013087 binding surface 229193013088 TPR motif; other site 229193013089 probable transmembrane helix predicted by TMHMM2.0 229193013090 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 229193013091 probable transmembrane helix predicted by TMHMM2.0 229193013092 probable transmembrane helix predicted by TMHMM2.0 229193013093 probable transmembrane helix predicted by TMHMM2.0 229193013094 probable transmembrane helix predicted by TMHMM2.0 229193013095 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 229193013096 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 229193013097 probable transmembrane helix predicted by TMHMM2.0 229193013098 probable transmembrane helix predicted by TMHMM2.0 229193013099 probable transmembrane helix predicted by TMHMM2.0 229193013100 probable transmembrane helix predicted by TMHMM2.0 229193013101 probable transmembrane helix predicted by TMHMM2.0 229193013102 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 229193013103 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 229193013104 ATP binding site [chemical binding]; other site 229193013105 Walker A motif; other site 229193013106 hexamer interface [polypeptide binding]; other site 229193013107 Walker B motif; other site 229193013108 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 229193013109 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 229193013110 probable transmembrane helix predicted by TMHMM2.0 229193013111 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 229193013112 probable transmembrane helix predicted by TMHMM2.0 229193013113 probable transmembrane helix predicted by TMHMM2.0 229193013114 probable transmembrane helix predicted by TMHMM2.0 229193013115 probable transmembrane helix predicted by TMHMM2.0 229193013116 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193013117 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 229193013118 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193013119 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 229193013120 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 229193013121 probable transmembrane helix predicted by TMHMM2.0 229193013122 probable transmembrane helix predicted by TMHMM2.0 229193013123 probable transmembrane helix predicted by TMHMM2.0 229193013124 ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592 229193013125 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 229193013126 siderophore binding site; other site 229193013127 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 229193013128 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 229193013129 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 229193013130 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 229193013131 probable transmembrane helix predicted by TMHMM2.0 229193013132 probable transmembrane helix predicted by TMHMM2.0 229193013133 probable transmembrane helix predicted by TMHMM2.0 229193013134 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 229193013135 probable transmembrane helix predicted by TMHMM2.0 229193013136 probable transmembrane helix predicted by TMHMM2.0 229193013137 probable transmembrane helix predicted by TMHMM2.0 229193013138 probable transmembrane helix predicted by TMHMM2.0 229193013139 probable transmembrane helix predicted by TMHMM2.0 229193013140 probable transmembrane helix predicted by TMHMM2.0 229193013141 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 229193013142 probable transmembrane helix predicted by TMHMM2.0 229193013143 BlastProDom match to entry PD002710 sp_Q9R9X5_Q9R9X5_PSEPU, E-value 7e-08 229193013144 probable transmembrane helix predicted by TMHMM2.0 229193013145 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 229193013146 probable transmembrane helix predicted by TMHMM2.0 229193013147 probable transmembrane helix predicted by TMHMM2.0 229193013148 probable transmembrane helix predicted by TMHMM2.0 229193013149 probable transmembrane helix predicted by TMHMM2.0 229193013150 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 229193013151 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 229193013152 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 229193013153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193013154 Walker A motif; other site 229193013155 ATP binding site [chemical binding]; other site 229193013156 Walker B motif; other site 229193013157 arginine finger; other site 229193013158 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 229193013159 ProfileScan match to entry PS50116 HTH_FIS_FAMILY, E-value 11.682 229193013160 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 229193013161 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 229193013162 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 229193013163 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 229193013164 probable transmembrane helix predicted by TMHMM2.0 229193013165 ProfileScan match to entry PS50310 ALA_RICH, E-value 9.179 229193013166 probable transmembrane helix predicted by TMHMM2.0 229193013167 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 229193013168 MgtE intracellular N domain; Region: MgtE_N; smart00924 229193013169 FliG C-terminal domain; Region: FliG_C; pfam01706 229193013170 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 229193013171 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 229193013172 Flagellar assembly protein FliH; Region: FliH; pfam02108 229193013173 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 229193013174 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 229193013175 Walker A motif; other site 229193013176 ATP binding site [chemical binding]; other site 229193013177 Walker B motif; other site 229193013178 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 229193013179 ProfileScan match to entry PS50322 GLN_RICH, E-value 14.147 229193013180 FlgN protein; Region: FlgN; pfam05130 229193013181 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 229193013182 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 229193013183 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 229193013184 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 229193013185 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 229193013186 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 229193013187 BlastProDom match to entry PD004851 sp_Q56893_FLGB_YEREN, E-value 7e-65 229193013188 BlastProDom match to entry PD004851 sp_P75934_FLGB_ECOLI, E-value 4e-16 229193013189 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 229193013190 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 229193013191 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619 229193013192 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 229193013193 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 229193013194 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 229193013195 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 229193013196 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 229193013197 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 229193013198 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 229193013199 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 229193013200 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 229193013201 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 229193013202 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 229193013203 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 229193013204 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 229193013205 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 229193013206 Flagellar L-ring protein; Region: FlgH; pfam02107 229193013207 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 229193013208 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 229193013209 peptidoglycan hydrolase; Reviewed; Region: flgJ; PRK12708 229193013210 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 229193013211 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 229193013212 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 229193013213 probable transmembrane helix predicted by TMHMM2.0 229193013214 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 229193013215 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193013216 DNA binding site [nucleotide binding] 229193013217 Contains Flagellin, N-terminal (Interpro|IPR001492, (GO:0001539), (GO:0009420)) . Contains Flagellin, N-terminal (Interpro|IPR001492, (GO:0001539), (GO:0009420)) 229193013218 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 229193013219 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 229193013220 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 229193013221 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 229193013222 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 229193013223 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 229193013224 putative trimer interface [polypeptide binding]; other site 229193013225 putative CoA binding site [chemical binding]; other site 229193013226 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 229193013227 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 229193013228 probable transmembrane helix predicted by TMHMM2.0 229193013229 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 229193013230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 229193013231 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 229193013232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 229193013233 DNA binding residues [nucleotide binding] 229193013234 HMMPfam match to entry PF04542 sigma70_r2, E-value 1.5e-15 229193013235 HMMPfam match to entry PF04542 sigma70_r2, E-value 7.2e-12 229193013236 HMMPfam match to entry PF04539 sigma70_r3, E-value 3.3e-11 229193013237 HMMPfam match to entry PF04539 sigma70_r3, E-value 0.0099 229193013238 HMMPfam match to entry PF04545 sigma70_r4, E-value 1.3e-12 229193013239 HMMPfam match to entry PF04545 sigma70_r4, E-value 2.7e-18 229193013240 flagellar motor protein MotA; Provisional; Region: PRK12482 229193013241 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 229193013242 probable transmembrane helix predicted by TMHMM2.0 229193013243 probable transmembrane helix predicted by TMHMM2.0 229193013244 probable transmembrane helix predicted by TMHMM2.0 229193013245 probable transmembrane helix predicted by TMHMM2.0 229193013246 hypothetical protein; Validated; Region: PRK06778 229193013247 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 229193013248 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 229193013249 ligand binding site [chemical binding]; other site 229193013250 probable transmembrane helix predicted by TMHMM2.0 229193013251 probable transmembrane helix predicted by TMHMM2.0 229193013252 probable transmembrane helix predicted by TMHMM2.0 229193013253 probable transmembrane helix predicted by TMHMM2.0 229193013254 probable transmembrane helix predicted by TMHMM2.0 229193013255 Protein of unknown function (DUF805); Region: DUF805; pfam05656 229193013256 probable transmembrane helix predicted by TMHMM2.0 229193013257 probable transmembrane helix predicted by TMHMM2.0 229193013258 probable transmembrane helix predicted by TMHMM2.0 229193013259 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 229193013260 probable transmembrane helix predicted by TMHMM2.0 229193013261 probable transmembrane helix predicted by TMHMM2.0 229193013262 probable transmembrane helix predicted by TMHMM2.0 229193013263 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 229193013264 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193013265 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193013266 putative transposase OrfB; Reviewed; Region: PHA02517 229193013267 HTH-like domain; Region: HTH_21; pfam13276 229193013268 Integrase core domain; Region: rve; pfam00665 229193013269 Integrase core domain; Region: rve_2; pfam13333 229193013270 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 229193013271 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 229193013272 Protein of unknown function (DUF877); Region: DUF877; pfam05943 229193013273 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 229193013274 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 229193013275 maltose regulon periplasmic protein; Provisional; Region: PRK10564 229193013276 probable transmembrane helix predicted by TMHMM2.0 229193013277 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 229193013278 trimer interface; other site 229193013279 sugar binding site [chemical binding]; other site 229193013280 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 229193013281 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 229193013282 Walker A/P-loop; other site 229193013283 ATP binding site [chemical binding]; other site 229193013284 Q-loop/lid; other site 229193013285 ABC transporter signature motif; other site 229193013286 Walker B; other site 229193013287 D-loop; other site 229193013288 H-loop/switch region; other site 229193013289 TOBE domain; Region: TOBE_2; pfam08402 229193013290 BlastProDom match to entry PD039360 sp_Q57585_Y121_METJA, E-value 1e-07 229193013291 BlastProDom match to entry PD039360 sp_O27709_O27709_METTH, E-value 2e-08 229193013292 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 229193013293 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 229193013294 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 229193013295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193013296 dimer interface [polypeptide binding]; other site 229193013297 conserved gate region; other site 229193013298 putative PBP binding loops; other site 229193013299 ABC-ATPase subunit interface; other site 229193013300 HMMPfam match to entry PF05154 TM2, E-value 1.9e-05 229193013301 probable transmembrane helix predicted by TMHMM2.0 229193013302 probable transmembrane helix predicted by TMHMM2.0 229193013303 probable transmembrane helix predicted by TMHMM2.0 229193013304 probable transmembrane helix predicted by TMHMM2.0 229193013305 probable transmembrane helix predicted by TMHMM2.0 229193013306 probable transmembrane helix predicted by TMHMM2.0 229193013307 probable transmembrane helix predicted by TMHMM2.0 229193013308 probable transmembrane helix predicted by TMHMM2.0 229193013309 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 229193013310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193013311 dimer interface [polypeptide binding]; other site 229193013312 conserved gate region; other site 229193013313 putative PBP binding loops; other site 229193013314 ABC-ATPase subunit interface; other site 229193013315 probable transmembrane helix predicted by TMHMM2.0 229193013316 probable transmembrane helix predicted by TMHMM2.0 229193013317 probable transmembrane helix predicted by TMHMM2.0 229193013318 probable transmembrane helix predicted by TMHMM2.0 229193013319 probable transmembrane helix predicted by TMHMM2.0 229193013320 probable transmembrane helix predicted by TMHMM2.0 229193013321 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 229193013322 probable transmembrane helix predicted by TMHMM2.0 229193013323 probable transmembrane helix predicted by TMHMM2.0 229193013324 probable transmembrane helix predicted by TMHMM2.0 229193013325 probable transmembrane helix predicted by TMHMM2.0 229193013326 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 229193013327 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 229193013328 active site 229193013329 dimer interface [polypeptide binding]; other site 229193013330 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 229193013331 dimer interface [polypeptide binding]; other site 229193013332 active site 229193013333 aspartate kinase III; Validated; Region: PRK09084 229193013334 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 229193013335 nucleotide binding site [chemical binding]; other site 229193013336 substrate binding site [chemical binding]; other site 229193013337 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 229193013338 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 229193013339 dimer interface [polypeptide binding]; other site 229193013340 Contains Hemolysin activator HlyB (Interpro|IPR005565) 229193013341 haemagglutination activity domain; Region: Haemagg_act; pfam05860 229193013342 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 229193013343 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 229193013344 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 229193013345 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 229193013346 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 229193013347 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 229193013348 probable transmembrane helix predicted by TMHMM2.0 229193013349 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 229193013350 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 229193013351 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 229193013352 substrate binding pocket [chemical binding]; other site 229193013353 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 229193013354 B12 binding site [chemical binding]; other site 229193013355 cobalt ligand [ion binding]; other site 229193013356 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 229193013357 transcriptional repressor IclR; Provisional; Region: PRK11569 229193013358 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 229193013359 Bacterial transcriptional regulator; Region: IclR; pfam01614 229193013360 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 229193013361 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 229193013362 isocitrate lyase; Provisional; Region: PRK15063 229193013363 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 229193013364 tetramer interface [polypeptide binding]; other site 229193013365 active site 229193013366 Mg2+/Mn2+ binding site [ion binding]; other site 229193013367 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 229193013368 malate synthase A; Region: malate_syn_A; TIGR01344 229193013369 active site 229193013370 homoserine O-succinyltransferase; Provisional; Region: PRK05368 229193013371 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 229193013372 proposed active site lysine [active] 229193013373 conserved cys residue [active] 229193013374 HMMPfam match to entry PF04204 HTS, E-value 2.8e-216 229193013375 rRNA operon 229193013376 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 229193013377 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 229193013378 purine monophosphate binding site [chemical binding]; other site 229193013379 dimer interface [polypeptide binding]; other site 229193013380 putative catalytic residues [active] 229193013381 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 229193013382 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 229193013383 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 229193013384 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 229193013385 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 229193013386 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 229193013387 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 229193013388 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 229193013389 IHF dimer interface [polypeptide binding]; other site 229193013390 IHF - DNA interface [nucleotide binding]; other site 229193013391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 229193013392 HMMPfam match to entry PF04222 DUF416, E-value 1.1e-133 229193013393 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 229193013394 Active_site [active] 229193013395 HMMPfam match to entry PF04493 Endonuc_V, E-value 1.9e-97 229193013396 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 229193013397 substrate binding site [chemical binding]; other site 229193013398 active site 229193013399 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 229193013400 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 229193013401 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 229193013402 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 229193013403 putative NADH binding site [chemical binding]; other site 229193013404 putative active site [active] 229193013405 nudix motif; other site 229193013406 putative metal binding site [ion binding]; other site 229193013407 HMMPfam match to entry PF04353 Rsd_AlgQ, E-value 1.5e-50 229193013408 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 229193013409 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 229193013410 ThiC-associated domain; Region: ThiC-associated; pfam13667 229193013411 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 229193013412 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 229193013413 thiamine phosphate binding site [chemical binding]; other site 229193013414 active site 229193013415 pyrophosphate binding site [ion binding]; other site 229193013416 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 229193013417 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 229193013418 ATP binding site [chemical binding]; other site 229193013419 substrate interface [chemical binding]; other site 229193013420 probable transmembrane helix predicted by TMHMM2.0 229193013421 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 229193013422 thiS-thiF/thiG interaction site; other site 229193013423 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 229193013424 ThiS interaction site; other site 229193013425 putative active site [active] 229193013426 tetramer interface [polypeptide binding]; other site 229193013427 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 229193013428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193013429 FeS/SAM binding site; other site 229193013430 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 229193013431 HMMPfam match to entry PF04055 Radical_SAM, E-value 8.1e-09 229193013432 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 229193013433 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 229193013434 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 229193013435 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 229193013436 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 229193013437 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 229193013438 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 229193013439 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 229193013440 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 229193013441 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 229193013442 DNA binding site [nucleotide binding] 229193013443 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 229193013444 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 229193013445 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 229193013446 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 229193013447 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 229193013448 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 229193013449 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 229193013450 RPB3 interaction site [polypeptide binding]; other site 229193013451 RPB1 interaction site [polypeptide binding]; other site 229193013452 RPB11 interaction site [polypeptide binding]; other site 229193013453 RPB10 interaction site [polypeptide binding]; other site 229193013454 HMMPfam match to entry PF04560 RNA_pol_Rpb2_7, E-value 2.1e-50 229193013455 HMMPfam match to entry PF04565 RNA_pol_Rpb2_3, E-value 7.2e-44 229193013456 HMMPfam match to entry PF04563 RNA_pol_Rpb2_1, E-value 5.9e-17 229193013457 HMMPfam match to entry PF04561 RNA_pol_Rpb2_2, E-value 1.3e-05 229193013458 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 229193013459 core dimer interface [polypeptide binding]; other site 229193013460 peripheral dimer interface [polypeptide binding]; other site 229193013461 L10 interface [polypeptide binding]; other site 229193013462 L11 interface [polypeptide binding]; other site 229193013463 putative EF-Tu interaction site [polypeptide binding]; other site 229193013464 putative EF-G interaction site [polypeptide binding]; other site 229193013465 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 229193013466 23S rRNA interface [nucleotide binding]; other site 229193013467 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 229193013468 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 229193013469 mRNA/rRNA interface [nucleotide binding]; other site 229193013470 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 229193013471 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 229193013472 23S rRNA interface [nucleotide binding]; other site 229193013473 L7/L12 interface [polypeptide binding]; other site 229193013474 putative thiostrepton binding site; other site 229193013475 L25 interface [polypeptide binding]; other site 229193013476 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 229193013477 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 229193013478 putative homodimer interface [polypeptide binding]; other site 229193013479 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 229193013480 heterodimer interface [polypeptide binding]; other site 229193013481 homodimer interface [polypeptide binding]; other site 229193013482 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 229193013483 probable transmembrane helix predicted by TMHMM2.0 229193013484 probable transmembrane helix predicted by TMHMM2.0 229193013485 probable transmembrane helix predicted by TMHMM2.0 229193013486 elongation factor Tu; Reviewed; Region: PRK00049 229193013487 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 229193013488 G1 box; other site 229193013489 GEF interaction site [polypeptide binding]; other site 229193013490 GTP/Mg2+ binding site [chemical binding]; other site 229193013491 Switch I region; other site 229193013492 G2 box; other site 229193013493 G3 box; other site 229193013494 Switch II region; other site 229193013495 G4 box; other site 229193013496 G5 box; other site 229193013497 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 229193013498 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 229193013499 Antibiotic Binding Site [chemical binding]; other site 229193013500 putative transposase OrfB; Reviewed; Region: PHA02517 229193013501 HTH-like domain; Region: HTH_21; pfam13276 229193013502 Integrase core domain; Region: rve; pfam00665 229193013503 Integrase core domain; Region: rve_2; pfam13333 229193013504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 229193013505 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193013506 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193013507 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 229193013508 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 229193013509 acetylornithine deacetylase; Provisional; Region: PRK05111 229193013510 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 229193013511 metal binding site [ion binding]; metal-binding site 229193013512 putative dimer interface [polypeptide binding]; other site 229193013513 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 229193013514 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 229193013515 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 229193013516 nucleotide binding site [chemical binding]; other site 229193013517 N-acetyl-L-glutamate binding site [chemical binding]; other site 229193013518 argininosuccinate lyase; Provisional; Region: PRK04833 229193013519 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 229193013520 active sites [active] 229193013521 tetramer interface [polypeptide binding]; other site 229193013522 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 229193013523 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 229193013524 N-terminal plug; other site 229193013525 ligand-binding site [chemical binding]; other site 229193013526 Heme-binding protein A (HasA); Region: HasA; pfam06438 229193013527 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 229193013528 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 229193013529 Walker A/P-loop; other site 229193013530 ATP binding site [chemical binding]; other site 229193013531 Q-loop/lid; other site 229193013532 ABC transporter signature motif; other site 229193013533 Walker B; other site 229193013534 D-loop; other site 229193013535 H-loop/switch region; other site 229193013536 probable transmembrane helix predicted by TMHMM2.0 229193013537 probable transmembrane helix predicted by TMHMM2.0 229193013538 probable transmembrane helix predicted by TMHMM2.0 229193013539 probable transmembrane helix predicted by TMHMM2.0 229193013540 probable transmembrane helix predicted by TMHMM2.0 229193013541 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 229193013542 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 229193013543 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193013544 probable transmembrane helix predicted by TMHMM2.0 229193013545 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 229193013546 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 229193013547 probable transmembrane helix predicted by TMHMM2.0 229193013548 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 229193013549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 229193013550 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 229193013551 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 229193013552 catalytic triad [active] 229193013553 dimer interface [polypeptide binding]; other site 229193013554 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 229193013555 GSH binding site [chemical binding]; other site 229193013556 catalytic residues [active] 229193013557 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 229193013558 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193013559 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 229193013560 dimerization interface [polypeptide binding]; other site 229193013561 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 229193013562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 229193013563 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 229193013564 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 229193013565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 229193013566 hypothetical protein; Provisional; Region: PRK11056 229193013567 probable transmembrane helix predicted by TMHMM2.0 229193013568 probable transmembrane helix predicted by TMHMM2.0 229193013569 probable transmembrane helix predicted by TMHMM2.0 229193013570 probable transmembrane helix predicted by TMHMM2.0 229193013571 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 229193013572 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 229193013573 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 229193013574 N-terminal plug; other site 229193013575 ligand-binding site [chemical binding]; other site 229193013576 glutamate racemase; Provisional; Region: PRK00865 229193013577 rRNA operon 229193013578 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 229193013579 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 229193013580 putative ligand binding site [chemical binding]; other site 229193013581 probable transmembrane helix predicted by TMHMM2.0 229193013582 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 229193013583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193013584 Walker A/P-loop; other site 229193013585 ATP binding site [chemical binding]; other site 229193013586 Q-loop/lid; other site 229193013587 ABC transporter signature motif; other site 229193013588 Walker B; other site 229193013589 D-loop; other site 229193013590 H-loop/switch region; other site 229193013591 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193013592 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193013593 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193013594 TM-ABC transporter signature motif; other site 229193013595 probable transmembrane helix predicted by TMHMM2.0 229193013596 probable transmembrane helix predicted by TMHMM2.0 229193013597 probable transmembrane helix predicted by TMHMM2.0 229193013598 probable transmembrane helix predicted by TMHMM2.0 229193013599 probable transmembrane helix predicted by TMHMM2.0 229193013600 probable transmembrane helix predicted by TMHMM2.0 229193013601 probable transmembrane helix predicted by TMHMM2.0 229193013602 probable transmembrane helix predicted by TMHMM2.0 229193013603 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193013604 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193013605 TM-ABC transporter signature motif; other site 229193013606 probable transmembrane helix predicted by TMHMM2.0 229193013607 probable transmembrane helix predicted by TMHMM2.0 229193013608 probable transmembrane helix predicted by TMHMM2.0 229193013609 probable transmembrane helix predicted by TMHMM2.0 229193013610 probable transmembrane helix predicted by TMHMM2.0 229193013611 probable transmembrane helix predicted by TMHMM2.0 229193013612 probable transmembrane helix predicted by TMHMM2.0 229193013613 probable transmembrane helix predicted by TMHMM2.0 229193013614 probable transmembrane helix predicted by TMHMM2.0 229193013615 transcriptional regulator HdfR; Provisional; Region: PRK03601 229193013616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193013617 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 229193013618 dimerization interface [polypeptide binding]; other site 229193013619 hypothetical protein; Provisional; Region: PRK11027 229193013620 HMMPfam match to entry PF04219 DUF413, E-value 1.4e-44 229193013621 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 229193013622 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 229193013623 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 229193013624 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 229193013625 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 229193013626 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 229193013627 PYR/PP interface [polypeptide binding]; other site 229193013628 dimer interface [polypeptide binding]; other site 229193013629 TPP binding site [chemical binding]; other site 229193013630 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 229193013631 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 229193013632 TPP-binding site [chemical binding]; other site 229193013633 dimer interface [polypeptide binding]; other site 229193013634 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 229193013635 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 229193013636 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 229193013637 homodimer interface [polypeptide binding]; other site 229193013638 substrate-cofactor binding pocket; other site 229193013639 catalytic residue [active] 229193013640 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 229193013641 threonine dehydratase; Reviewed; Region: PRK09224 229193013642 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 229193013643 tetramer interface [polypeptide binding]; other site 229193013644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193013645 catalytic residue [active] 229193013646 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 229193013647 putative Ile/Val binding site [chemical binding]; other site 229193013648 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 229193013649 putative Ile/Val binding site [chemical binding]; other site 229193013650 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 229193013651 probable transmembrane helix predicted by TMHMM2.0 229193013652 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 229193013653 probable transmembrane helix predicted by TMHMM2.0 229193013654 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 229193013655 probable transmembrane helix predicted by TMHMM2.0 229193013656 conserved hypothetical protein; Region: TIGR03034 229193013657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193013658 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 229193013659 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 229193013660 putative dimerization interface [polypeptide binding]; other site 229193013661 ketol-acid reductoisomerase; Validated; Region: PRK05225 229193013662 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 229193013663 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 229193013664 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 229193013665 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 229193013666 cystathionine beta-lyase; Provisional; Region: PRK09028 229193013667 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 229193013668 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193013669 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 229193013670 probable transmembrane helix predicted by TMHMM2.0 229193013671 Fimbrial protein; Region: Fimbrial; cl01416 229193013672 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 229193013673 PapC N-terminal domain; Region: PapC_N; pfam13954 229193013674 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 229193013675 PapC C-terminal domain; Region: PapC_C; pfam13953 229193013676 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 229193013677 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193013678 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 229193013679 probable transmembrane helix predicted by TMHMM2.0 229193013680 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 229193013681 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 229193013682 HMMPfam match to entry PF05096 Glu_cyclase_2, E-value 2.7e-57 229193013683 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 229193013684 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 229193013685 BlastProDom match to entry PD002510 sp_P39159_PPIC_ECOLI, E-value 3e-27 229193013686 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 229193013687 Part of AAA domain; Region: AAA_19; pfam13245 229193013688 Family description; Region: UvrD_C_2; pfam13538 229193013689 probable transmembrane helix predicted by TMHMM2.0 229193013690 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 229193013691 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 229193013692 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 229193013693 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 229193013694 ATP binding site [chemical binding]; other site 229193013695 Mg++ binding site [ion binding]; other site 229193013696 motif III; other site 229193013697 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193013698 nucleotide binding region [chemical binding]; other site 229193013699 ATP-binding site [chemical binding]; other site 229193013700 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 229193013701 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 229193013702 catalytic residues [active] 229193013703 transcription termination factor Rho; Provisional; Region: rho; PRK09376 229193013704 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 229193013705 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 229193013706 RNA binding site [nucleotide binding]; other site 229193013707 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 229193013708 multimer interface [polypeptide binding]; other site 229193013709 Walker A motif; other site 229193013710 ATP binding site [chemical binding]; other site 229193013711 Walker B motif; other site 229193013712 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 229193013713 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 229193013714 Mg++ binding site [ion binding]; other site 229193013715 putative catalytic motif [active] 229193013716 substrate binding site [chemical binding]; other site 229193013717 probable transmembrane helix predicted by TMHMM2.0 229193013718 probable transmembrane helix predicted by TMHMM2.0 229193013719 probable transmembrane helix predicted by TMHMM2.0 229193013720 probable transmembrane helix predicted by TMHMM2.0 229193013721 probable transmembrane helix predicted by TMHMM2.0 229193013722 probable transmembrane helix predicted by TMHMM2.0 229193013723 probable transmembrane helix predicted by TMHMM2.0 229193013724 probable transmembrane helix predicted by TMHMM2.0 229193013725 probable transmembrane helix predicted by TMHMM2.0 229193013726 probable transmembrane helix predicted by TMHMM2.0 229193013727 probable transmembrane helix predicted by TMHMM2.0 229193013728 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 229193013729 Chain length determinant protein; Region: Wzz; cl15801 229193013730 probable transmembrane helix predicted by TMHMM2.0 229193013731 probable transmembrane helix predicted by TMHMM2.0 229193013732 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 229193013733 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 229193013734 active site 229193013735 homodimer interface [polypeptide binding]; other site 229193013736 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 229193013737 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 229193013738 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 229193013739 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 229193013740 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 229193013741 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 229193013742 NAD binding site [chemical binding]; other site 229193013743 substrate binding site [chemical binding]; other site 229193013744 homodimer interface [polypeptide binding]; other site 229193013745 active site 229193013746 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 229193013747 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 229193013748 substrate binding site; other site 229193013749 tetramer interface; other site 229193013750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 229193013751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 229193013752 Coenzyme A binding pocket [chemical binding]; other site 229193013753 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 229193013754 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 229193013755 inhibitor-cofactor binding pocket; inhibition site 229193013756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193013757 catalytic residue [active] 229193013758 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 229193013759 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 229193013760 probable transmembrane helix predicted by TMHMM2.0 229193013761 probable transmembrane helix predicted by TMHMM2.0 229193013762 probable transmembrane helix predicted by TMHMM2.0 229193013763 probable transmembrane helix predicted by TMHMM2.0 229193013764 probable transmembrane helix predicted by TMHMM2.0 229193013765 probable transmembrane helix predicted by TMHMM2.0 229193013766 probable transmembrane helix predicted by TMHMM2.0 229193013767 probable transmembrane helix predicted by TMHMM2.0 229193013768 probable transmembrane helix predicted by TMHMM2.0 229193013769 probable transmembrane helix predicted by TMHMM2.0 229193013770 probable transmembrane helix predicted by TMHMM2.0 229193013771 probable transmembrane helix predicted by TMHMM2.0 229193013772 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 229193013773 putative common antigen polymerase; Provisional; Region: PRK02975 229193013774 probable transmembrane helix predicted by TMHMM2.0 229193013775 probable transmembrane helix predicted by TMHMM2.0 229193013776 probable transmembrane helix predicted by TMHMM2.0 229193013777 probable transmembrane helix predicted by TMHMM2.0 229193013778 probable transmembrane helix predicted by TMHMM2.0 229193013779 probable transmembrane helix predicted by TMHMM2.0 229193013780 probable transmembrane helix predicted by TMHMM2.0 229193013781 probable transmembrane helix predicted by TMHMM2.0 229193013782 probable transmembrane helix predicted by TMHMM2.0 229193013783 probable transmembrane helix predicted by TMHMM2.0 229193013784 probable transmembrane helix predicted by TMHMM2.0 229193013785 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 229193013786 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 229193013787 putative transport protein YifK; Provisional; Region: PRK10746 229193013788 probable transmembrane helix predicted by TMHMM2.0 229193013789 probable transmembrane helix predicted by TMHMM2.0 229193013790 probable transmembrane helix predicted by TMHMM2.0 229193013791 probable transmembrane helix predicted by TMHMM2.0 229193013792 probable transmembrane helix predicted by TMHMM2.0 229193013793 probable transmembrane helix predicted by TMHMM2.0 229193013794 probable transmembrane helix predicted by TMHMM2.0 229193013795 probable transmembrane helix predicted by TMHMM2.0 229193013796 probable transmembrane helix predicted by TMHMM2.0 229193013797 probable transmembrane helix predicted by TMHMM2.0 229193013798 probable transmembrane helix predicted by TMHMM2.0 229193013799 probable transmembrane helix predicted by TMHMM2.0 229193013800 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193013801 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 229193013802 HemY protein N-terminus; Region: HemY_N; pfam07219 229193013803 probable transmembrane helix predicted by TMHMM2.0 229193013804 probable transmembrane helix predicted by TMHMM2.0 229193013805 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 229193013806 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 229193013807 HMMPfam match to entry PF04375 DUF513, E-value 9.6e-71 229193013808 HMMPfam match to entry PF04374 DUF514, E-value 1.9e-57 229193013809 ProfileScan match to entry PS50322 GLN_RICH, E-value 9.909 229193013810 probable transmembrane helix predicted by TMHMM2.0 229193013811 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 229193013812 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 229193013813 active site 229193013814 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 229193013815 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 229193013816 domain interfaces; other site 229193013817 active site 229193013818 probable transmembrane helix predicted by TMHMM2.0 229193013819 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 229193013820 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 229193013821 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 229193013822 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 229193013823 putative iron binding site [ion binding]; other site 229193013824 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 229193013825 probable transmembrane helix predicted by TMHMM2.0 229193013826 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 229193013827 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 229193013828 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 229193013829 BlastProDom match to entry PD005029 sp_P08885_DAPF_ECOLI, E-value e-128 229193013830 hypothetical protein; Provisional; Region: PRK10963 229193013831 HMMPfam match to entry PF04340 DUF484, E-value 4.3e-86 229193013832 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 229193013833 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 229193013834 active site 229193013835 DNA binding site [nucleotide binding] 229193013836 Int/Topo IB signature motif; other site 229193013837 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 229193013838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193013839 motif II; other site 229193013840 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 229193013841 Part of AAA domain; Region: AAA_19; pfam13245 229193013842 Family description; Region: UvrD_C_2; pfam13538 229193013843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 229193013844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 229193013845 Uncharacterized conserved protein [Function unknown]; Region: COG5441 229193013846 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 229193013847 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 229193013848 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 229193013849 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 229193013850 Cl binding site [ion binding]; other site 229193013851 oligomer interface [polypeptide binding]; other site 229193013852 probable transmembrane helix predicted by TMHMM2.0 229193013853 probable transmembrane helix predicted by TMHMM2.0 229193013854 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 229193013855 EamA-like transporter family; Region: EamA; cl17759 229193013856 probable transmembrane helix predicted by TMHMM2.0 229193013857 probable transmembrane helix predicted by TMHMM2.0 229193013858 probable transmembrane helix predicted by TMHMM2.0 229193013859 probable transmembrane helix predicted by TMHMM2.0 229193013860 probable transmembrane helix predicted by TMHMM2.0 229193013861 probable transmembrane helix predicted by TMHMM2.0 229193013862 probable transmembrane helix predicted by TMHMM2.0 229193013863 probable transmembrane helix predicted by TMHMM2.0 229193013864 probable transmembrane helix predicted by TMHMM2.0 229193013865 probable transmembrane helix predicted by TMHMM2.0 229193013866 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 229193013867 CoenzymeA binding site [chemical binding]; other site 229193013868 subunit interaction site [polypeptide binding]; other site 229193013869 PHB binding site; other site 229193013870 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 229193013871 substrate binding site [chemical binding]; other site 229193013872 dimerization interface [polypeptide binding]; other site 229193013873 active site 229193013874 calcium binding site [ion binding]; other site 229193013875 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 229193013876 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 229193013877 ATP binding site [chemical binding]; other site 229193013878 putative Mg++ binding site [ion binding]; other site 229193013879 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193013880 nucleotide binding region [chemical binding]; other site 229193013881 ATP-binding site [chemical binding]; other site 229193013882 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 229193013883 HRDC domain; Region: HRDC; pfam00570 229193013884 threonine efflux system; Provisional; Region: PRK10229 229193013885 probable transmembrane helix predicted by TMHMM2.0 229193013886 probable transmembrane helix predicted by TMHMM2.0 229193013887 probable transmembrane helix predicted by TMHMM2.0 229193013888 probable transmembrane helix predicted by TMHMM2.0 229193013889 probable transmembrane helix predicted by TMHMM2.0 229193013890 probable transmembrane helix predicted by TMHMM2.0 229193013891 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 229193013892 probable transmembrane helix predicted by TMHMM2.0 229193013893 probable transmembrane helix predicted by TMHMM2.0 229193013894 probable transmembrane helix predicted by TMHMM2.0 229193013895 probable transmembrane helix predicted by TMHMM2.0 229193013896 probable transmembrane helix predicted by TMHMM2.0 229193013897 probable transmembrane helix predicted by TMHMM2.0 229193013898 lysophospholipase L2; Provisional; Region: PRK10749 229193013899 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 229193013900 putative hydrolase; Provisional; Region: PRK10976 229193013901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193013902 active site 229193013903 motif I; other site 229193013904 motif II; other site 229193013905 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 229193013906 Viral enhancin protein; Region: Enhancin; pfam03272 229193013907 Viral enhancin protein; Region: Enhancin; pfam03272 229193013908 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 229193013909 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 229193013910 active site 229193013911 catalytic site [active] 229193013912 metal binding site [ion binding]; metal-binding site 229193013913 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 229193013914 hydroxyglutarate oxidase; Provisional; Region: PRK11728 229193013915 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 229193013916 HMMPfam match to entry PF04324 fer2_BFD, E-value 1.1e-15 229193013917 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 229193013918 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 229193013919 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 229193013920 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 229193013921 Cysteine-rich domain; Region: CCG; pfam02754 229193013922 Cysteine-rich domain; Region: CCG; pfam02754 229193013923 hypothetical protein; Provisional; Region: PRK11615 229193013924 hypothetical protein; Provisional; Region: PRK11212 229193013925 probable transmembrane helix predicted by TMHMM2.0 229193013926 probable transmembrane helix predicted by TMHMM2.0 229193013927 probable transmembrane helix predicted by TMHMM2.0 229193013928 probable transmembrane helix predicted by TMHMM2.0 229193013929 probable transmembrane helix predicted by TMHMM2.0 229193013930 probable transmembrane helix predicted by TMHMM2.0 229193013931 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 229193013932 CPxP motif; other site 229193013933 BlastProDom match to entry PD004783 sp_P37618_SIRA_ECOLI, E-value 2e-27 229193013934 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 229193013935 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 229193013936 metal-binding site [ion binding] 229193013937 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 229193013938 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 229193013939 probable transmembrane helix predicted by TMHMM2.0 229193013940 probable transmembrane helix predicted by TMHMM2.0 229193013941 probable transmembrane helix predicted by TMHMM2.0 229193013942 probable transmembrane helix predicted by TMHMM2.0 229193013943 probable transmembrane helix predicted by TMHMM2.0 229193013944 probable transmembrane helix predicted by TMHMM2.0 229193013945 Predicted membrane protein [Function unknown]; Region: COG3714 229193013946 ProfileScan match to entry PS50319 LEU_RICH, E-value 12.764 229193013947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4517 229193013948 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 229193013949 probable transmembrane helix predicted by TMHMM2.0 229193013950 hypothetical protein; Provisional; Region: PRK10910 229193013951 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 229193013952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193013953 S-adenosylmethionine binding site [chemical binding]; other site 229193013954 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 229193013955 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 229193013956 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 229193013957 P loop; other site 229193013958 GTP binding site [chemical binding]; other site 229193013959 ProfileScan match to entry PS50313 GLU_RICH, E-value 12.062 229193013960 cell division protein FtsE; Provisional; Region: PRK10908 229193013961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193013962 Walker A/P-loop; other site 229193013963 ATP binding site [chemical binding]; other site 229193013964 Q-loop/lid; other site 229193013965 ABC transporter signature motif; other site 229193013966 Walker B; other site 229193013967 D-loop; other site 229193013968 H-loop/switch region; other site 229193013969 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 229193013970 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 229193013971 probable transmembrane helix predicted by TMHMM2.0 229193013972 probable transmembrane helix predicted by TMHMM2.0 229193013973 probable transmembrane helix predicted by TMHMM2.0 229193013974 probable transmembrane helix predicted by TMHMM2.0 229193013975 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 229193013976 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 229193013977 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 229193013978 DNA binding residues [nucleotide binding] 229193013979 HMMPfam match to entry PF04542 sigma70_r2, E-value 1.5e-20 229193013980 HMMPfam match to entry PF04545 sigma70_r4, E-value 1.2e-16 229193013981 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193013982 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 229193013983 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 229193013984 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 229193013985 dimerization interface [polypeptide binding]; other site 229193013986 ligand binding site [chemical binding]; other site 229193013987 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193013988 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 229193013989 TM-ABC transporter signature motif; other site 229193013990 probable transmembrane helix predicted by TMHMM2.0 229193013991 probable transmembrane helix predicted by TMHMM2.0 229193013992 probable transmembrane helix predicted by TMHMM2.0 229193013993 probable transmembrane helix predicted by TMHMM2.0 229193013994 probable transmembrane helix predicted by TMHMM2.0 229193013995 probable transmembrane helix predicted by TMHMM2.0 229193013996 probable transmembrane helix predicted by TMHMM2.0 229193013997 probable transmembrane helix predicted by TMHMM2.0 229193013998 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 229193013999 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 229193014000 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 229193014001 TM-ABC transporter signature motif; other site 229193014002 probable transmembrane helix predicted by TMHMM2.0 229193014003 probable transmembrane helix predicted by TMHMM2.0 229193014004 probable transmembrane helix predicted by TMHMM2.0 229193014005 probable transmembrane helix predicted by TMHMM2.0 229193014006 probable transmembrane helix predicted by TMHMM2.0 229193014007 probable transmembrane helix predicted by TMHMM2.0 229193014008 probable transmembrane helix predicted by TMHMM2.0 229193014009 probable transmembrane helix predicted by TMHMM2.0 229193014010 probable transmembrane helix predicted by TMHMM2.0 229193014011 probable transmembrane helix predicted by TMHMM2.0 229193014012 probable transmembrane helix predicted by TMHMM2.0 229193014013 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 229193014014 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 229193014015 Walker A/P-loop; other site 229193014016 ATP binding site [chemical binding]; other site 229193014017 Q-loop/lid; other site 229193014018 ABC transporter signature motif; other site 229193014019 Walker B; other site 229193014020 D-loop; other site 229193014021 H-loop/switch region; other site 229193014022 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 229193014023 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 229193014024 Walker A/P-loop; other site 229193014025 ATP binding site [chemical binding]; other site 229193014026 Q-loop/lid; other site 229193014027 ABC transporter signature motif; other site 229193014028 Walker B; other site 229193014029 D-loop; other site 229193014030 H-loop/switch region; other site 229193014031 probable transmembrane helix predicted by TMHMM2.0 229193014032 putative fimbrial protein TcfA; Provisional; Region: PRK15308 229193014033 putative fimbrial protein TcfA; Provisional; Region: PRK15308 229193014034 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 229193014035 probable transmembrane helix predicted by TMHMM2.0 229193014036 probable transmembrane helix predicted by TMHMM2.0 229193014037 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 229193014038 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 229193014039 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 229193014040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193014041 dimer interface [polypeptide binding]; other site 229193014042 conserved gate region; other site 229193014043 putative PBP binding loops; other site 229193014044 ABC-ATPase subunit interface; other site 229193014045 probable transmembrane helix predicted by TMHMM2.0 229193014046 probable transmembrane helix predicted by TMHMM2.0 229193014047 probable transmembrane helix predicted by TMHMM2.0 229193014048 probable transmembrane helix predicted by TMHMM2.0 229193014049 probable transmembrane helix predicted by TMHMM2.0 229193014050 probable transmembrane helix predicted by TMHMM2.0 229193014051 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 229193014052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193014053 dimer interface [polypeptide binding]; other site 229193014054 conserved gate region; other site 229193014055 putative PBP binding loops; other site 229193014056 ABC-ATPase subunit interface; other site 229193014057 probable transmembrane helix predicted by TMHMM2.0 229193014058 probable transmembrane helix predicted by TMHMM2.0 229193014059 probable transmembrane helix predicted by TMHMM2.0 229193014060 probable transmembrane helix predicted by TMHMM2.0 229193014061 probable transmembrane helix predicted by TMHMM2.0 229193014062 probable transmembrane helix predicted by TMHMM2.0 229193014063 probable transmembrane helix predicted by TMHMM2.0 229193014064 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 229193014065 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 229193014066 Walker A/P-loop; other site 229193014067 ATP binding site [chemical binding]; other site 229193014068 Q-loop/lid; other site 229193014069 ABC transporter signature motif; other site 229193014070 Walker B; other site 229193014071 D-loop; other site 229193014072 H-loop/switch region; other site 229193014073 TOBE domain; Region: TOBE_2; pfam08402 229193014074 BlastProDom match to entry PD039360 sp_Q57585_Y121_METJA, E-value 8e-10 229193014075 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 229193014076 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 229193014077 putative active site [active] 229193014078 catalytic site [active] 229193014079 putative metal binding site [ion binding]; other site 229193014080 Predicted permeases [General function prediction only]; Region: COG0679 229193014081 probable transmembrane helix predicted by TMHMM2.0 229193014082 probable transmembrane helix predicted by TMHMM2.0 229193014083 probable transmembrane helix predicted by TMHMM2.0 229193014084 probable transmembrane helix predicted by TMHMM2.0 229193014085 probable transmembrane helix predicted by TMHMM2.0 229193014086 probable transmembrane helix predicted by TMHMM2.0 229193014087 probable transmembrane helix predicted by TMHMM2.0 229193014088 probable transmembrane helix predicted by TMHMM2.0 229193014089 probable transmembrane helix predicted by TMHMM2.0 229193014090 probable transmembrane helix predicted by TMHMM2.0 229193014091 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 229193014092 probable transmembrane helix predicted by TMHMM2.0 229193014093 probable transmembrane helix predicted by TMHMM2.0 229193014094 probable transmembrane helix predicted by TMHMM2.0 229193014095 probable transmembrane helix predicted by TMHMM2.0 229193014096 probable transmembrane helix predicted by TMHMM2.0 229193014097 probable transmembrane helix predicted by TMHMM2.0 229193014098 probable transmembrane helix predicted by TMHMM2.0 229193014099 probable transmembrane helix predicted by TMHMM2.0 229193014100 probable transmembrane helix predicted by TMHMM2.0 229193014101 probable transmembrane helix predicted by TMHMM2.0 229193014102 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 229193014103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193014104 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 229193014105 putative dimerization interface [polypeptide binding]; other site 229193014106 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 229193014107 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 229193014108 THF binding site; other site 229193014109 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 229193014110 substrate binding site [chemical binding]; other site 229193014111 THF binding site; other site 229193014112 zinc-binding site [ion binding]; other site 229193014113 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 229193014114 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 229193014115 uridine phosphorylase; Provisional; Region: PRK11178 229193014116 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 229193014117 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 229193014118 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 229193014119 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 229193014120 Carbon starvation protein CstA; Region: CstA; pfam02554 229193014121 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 229193014122 probable transmembrane helix predicted by TMHMM2.0 229193014123 probable transmembrane helix predicted by TMHMM2.0 229193014124 probable transmembrane helix predicted by TMHMM2.0 229193014125 probable transmembrane helix predicted by TMHMM2.0 229193014126 probable transmembrane helix predicted by TMHMM2.0 229193014127 probable transmembrane helix predicted by TMHMM2.0 229193014128 probable transmembrane helix predicted by TMHMM2.0 229193014129 probable transmembrane helix predicted by TMHMM2.0 229193014130 probable transmembrane helix predicted by TMHMM2.0 229193014131 probable transmembrane helix predicted by TMHMM2.0 229193014132 probable transmembrane helix predicted by TMHMM2.0 229193014133 probable transmembrane helix predicted by TMHMM2.0 229193014134 probable transmembrane helix predicted by TMHMM2.0 229193014135 probable transmembrane helix predicted by TMHMM2.0 229193014136 probable transmembrane helix predicted by TMHMM2.0 229193014137 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 229193014138 probable transmembrane helix predicted by TMHMM2.0 229193014139 probable transmembrane helix predicted by TMHMM2.0 229193014140 probable transmembrane helix predicted by TMHMM2.0 229193014141 probable transmembrane helix predicted by TMHMM2.0 229193014142 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 229193014143 RmuC family; Region: RmuC; pfam02646 229193014144 probable transmembrane helix predicted by TMHMM2.0 229193014145 ProfileScan match to entry PS50322 GLN_RICH, E-value 10.936 229193014146 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 229193014147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193014148 S-adenosylmethionine binding site [chemical binding]; other site 229193014149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 229193014150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 229193014151 SCP-2 sterol transfer family; Region: SCP2; pfam02036 229193014152 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 229193014153 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 229193014154 probable transmembrane helix predicted by TMHMM2.0 229193014155 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 229193014156 probable transmembrane helix predicted by TMHMM2.0 229193014157 sec-independent translocase; Provisional; Region: PRK01770 229193014158 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 229193014159 probable transmembrane helix predicted by TMHMM2.0 229193014160 probable transmembrane helix predicted by TMHMM2.0 229193014161 probable transmembrane helix predicted by TMHMM2.0 229193014162 probable transmembrane helix predicted by TMHMM2.0 229193014163 probable transmembrane helix predicted by TMHMM2.0 229193014164 probable transmembrane helix predicted by TMHMM2.0 229193014165 tatD2; highly similar to gi|12644183|sp|P27859|TATD_ECOLI Mg-dependent DNase, Deoxyribonuclease tatD.; disrupted by IS100 element 229193014166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193014167 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193014168 DNA-binding interface [nucleotide binding]; DNA binding site 229193014169 Integrase core domain; Region: rve; pfam00665 229193014170 transposase/IS protein; Provisional; Region: PRK09183 229193014171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193014172 Walker A motif; other site 229193014173 ATP binding site [chemical binding]; other site 229193014174 Walker B motif; other site 229193014175 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 229193014176 dimer interface [polypeptide binding]; other site 229193014177 allosteric magnesium binding site [ion binding]; other site 229193014178 active site 229193014179 aspartate-rich active site metal binding site; other site 229193014180 Schiff base residues; other site 229193014181 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 229193014182 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 229193014183 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 229193014184 heterodimer interface [polypeptide binding]; other site 229193014185 homodimer interface [polypeptide binding]; other site 229193014186 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 229193014187 FMN reductase; Validated; Region: fre; PRK08051 229193014188 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 229193014189 FAD binding pocket [chemical binding]; other site 229193014190 FAD binding motif [chemical binding]; other site 229193014191 phosphate binding motif [ion binding]; other site 229193014192 beta-alpha-beta structure motif; other site 229193014193 NAD binding pocket [chemical binding]; other site 229193014194 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 229193014195 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 229193014196 dimer interface [polypeptide binding]; other site 229193014197 active site 229193014198 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 229193014199 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 229193014200 substrate binding site [chemical binding]; other site 229193014201 oxyanion hole (OAH) forming residues; other site 229193014202 trimer interface [polypeptide binding]; other site 229193014203 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 229193014204 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 229193014205 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 229193014206 proline dipeptidase; Provisional; Region: PRK13607 229193014207 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 229193014208 active site 229193014209 hypothetical protein; Provisional; Region: PRK11568 229193014210 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 229193014211 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 229193014212 potassium transporter; Provisional; Region: PRK10750 229193014213 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 229193014214 probable transmembrane helix predicted by TMHMM2.0 229193014215 probable transmembrane helix predicted by TMHMM2.0 229193014216 probable transmembrane helix predicted by TMHMM2.0 229193014217 probable transmembrane helix predicted by TMHMM2.0 229193014218 probable transmembrane helix predicted by TMHMM2.0 229193014219 probable transmembrane helix predicted by TMHMM2.0 229193014220 probable transmembrane helix predicted by TMHMM2.0 229193014221 probable transmembrane helix predicted by TMHMM2.0 229193014222 probable transmembrane helix predicted by TMHMM2.0 229193014223 probable transmembrane helix predicted by TMHMM2.0 229193014224 probable transmembrane helix predicted by TMHMM2.0 229193014225 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 229193014226 rRNA operon 229193014227 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 229193014228 FAD binding domain; Region: FAD_binding_4; pfam01565 229193014229 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 229193014230 Biotin operon repressor [Transcription]; Region: BirA; COG1654 229193014231 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 229193014232 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 229193014233 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 229193014234 pantothenate kinase; Provisional; Region: PRK05439 229193014235 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 229193014236 ATP-binding site [chemical binding]; other site 229193014237 CoA-binding site [chemical binding]; other site 229193014238 Mg2+-binding site [ion binding]; other site 229193014239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 229193014240 Coenzyme A binding pocket [chemical binding]; other site 229193014241 probable transmembrane helix predicted by TMHMM2.0 229193014242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193014243 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193014244 DNA-binding interface [nucleotide binding]; DNA binding site 229193014245 Integrase core domain; Region: rve; pfam00665 229193014246 transposase/IS protein; Provisional; Region: PRK09183 229193014247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193014248 Walker A motif; other site 229193014249 ATP binding site [chemical binding]; other site 229193014250 Walker B motif; other site 229193014251 probable transmembrane helix predicted by TMHMM2.0 229193014252 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 229193014253 probable transmembrane helix predicted by TMHMM2.0 229193014254 probable transmembrane helix predicted by TMHMM2.0 229193014255 probable transmembrane helix predicted by TMHMM2.0 229193014256 probable transmembrane helix predicted by TMHMM2.0 229193014257 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 229193014258 glycogen phosphorylase; Provisional; Region: PRK14986 229193014259 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 229193014260 homodimer interface [polypeptide binding]; other site 229193014261 active site pocket [active] 229193014262 glycogen synthase; Provisional; Region: glgA; PRK00654 229193014263 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 229193014264 ADP-binding pocket [chemical binding]; other site 229193014265 homodimer interface [polypeptide binding]; other site 229193014266 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 229193014267 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 229193014268 ligand binding site; other site 229193014269 oligomer interface; other site 229193014270 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 229193014271 sulfate 1 binding site; other site 229193014272 probable transmembrane helix predicted by TMHMM2.0 229193014273 glycogen debranching enzyme; Provisional; Region: PRK03705 229193014274 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 229193014275 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 229193014276 active site 229193014277 catalytic site [active] 229193014278 glycogen branching enzyme; Provisional; Region: PRK05402 229193014279 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 229193014280 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 229193014281 active site 229193014282 catalytic site [active] 229193014283 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 229193014284 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 229193014285 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 229193014286 Histidine kinase; Region: His_kinase; pfam06580 229193014287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193014288 ATP binding site [chemical binding]; other site 229193014289 Mg2+ binding site [ion binding]; other site 229193014290 G-X-G motif; other site 229193014291 probable transmembrane helix predicted by TMHMM2.0 229193014292 probable transmembrane helix predicted by TMHMM2.0 229193014293 probable transmembrane helix predicted by TMHMM2.0 229193014294 probable transmembrane helix predicted by TMHMM2.0 229193014295 probable transmembrane helix predicted by TMHMM2.0 229193014296 probable transmembrane helix predicted by TMHMM2.0 229193014297 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 229193014298 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 229193014299 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 229193014300 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 229193014301 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 229193014302 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 229193014303 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 229193014304 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 229193014305 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 229193014306 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 229193014307 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 229193014308 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 229193014309 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 229193014310 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 229193014311 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 229193014312 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 229193014313 ProfileScan match to entry PS50325 THR_RICH_1, E-value 11.314 229193014314 ProfileScan match to entry PS50325 THR_RICH_1, E-value 13.819 229193014315 ProfileScan match to entry PS50325 THR_RICH_1, E-value 8.964 229193014316 probable transmembrane helix predicted by TMHMM2.0 229193014317 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 229193014318 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 229193014319 putative antibiotic transporter; Provisional; Region: PRK10739 229193014320 probable transmembrane helix predicted by TMHMM2.0 229193014321 BlastProDom match to entry PD006289 sp_P46851_YHGN_ECOLI, E-value 2e-65 229193014322 probable transmembrane helix predicted by TMHMM2.0 229193014323 probable transmembrane helix predicted by TMHMM2.0 229193014324 probable transmembrane helix predicted by TMHMM2.0 229193014325 probable transmembrane helix predicted by TMHMM2.0 229193014326 probable transmembrane helix predicted by TMHMM2.0 229193014327 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 229193014328 AAA domain; Region: AAA_33; pfam13671 229193014329 ATP-binding site [chemical binding]; other site 229193014330 Gluconate-6-phosphate binding site [chemical binding]; other site 229193014331 high-affinity gluconate transporter; Provisional; Region: PRK14984 229193014332 gluconate transporter; Region: gntP; TIGR00791 229193014333 probable transmembrane helix predicted by TMHMM2.0 229193014334 probable transmembrane helix predicted by TMHMM2.0 229193014335 probable transmembrane helix predicted by TMHMM2.0 229193014336 probable transmembrane helix predicted by TMHMM2.0 229193014337 probable transmembrane helix predicted by TMHMM2.0 229193014338 probable transmembrane helix predicted by TMHMM2.0 229193014339 probable transmembrane helix predicted by TMHMM2.0 229193014340 probable transmembrane helix predicted by TMHMM2.0 229193014341 probable transmembrane helix predicted by TMHMM2.0 229193014342 probable transmembrane helix predicted by TMHMM2.0 229193014343 probable transmembrane helix predicted by TMHMM2.0 229193014344 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 229193014345 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193014346 DNA binding site [nucleotide binding] 229193014347 domain linker motif; other site 229193014348 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 229193014349 putative ligand binding site [chemical binding]; other site 229193014350 putative dimerization interface [polypeptide binding]; other site 229193014351 Pirin-related protein [General function prediction only]; Region: COG1741 229193014352 Pirin; Region: Pirin; pfam02678 229193014353 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 229193014354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193014355 active site 229193014356 phosphorylation site [posttranslational modification] 229193014357 intermolecular recognition site; other site 229193014358 dimerization interface [polypeptide binding]; other site 229193014359 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193014360 DNA binding site [nucleotide binding] 229193014361 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 229193014362 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 229193014363 substrate binding site [chemical binding]; other site 229193014364 ATP binding site [chemical binding]; other site 229193014365 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 229193014366 intersubunit interface [polypeptide binding]; other site 229193014367 active site 229193014368 zinc binding site [ion binding]; other site 229193014369 Na+ binding site [ion binding]; other site 229193014370 ABC-type sugar transport system, auxiliary component [General function prediction only]; Region: COG3822 229193014371 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 229193014372 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 229193014373 putative ligand binding site [chemical binding]; other site 229193014374 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193014375 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193014376 TM-ABC transporter signature motif; other site 229193014377 probable transmembrane helix predicted by TMHMM2.0 229193014378 probable transmembrane helix predicted by TMHMM2.0 229193014379 probable transmembrane helix predicted by TMHMM2.0 229193014380 probable transmembrane helix predicted by TMHMM2.0 229193014381 probable transmembrane helix predicted by TMHMM2.0 229193014382 probable transmembrane helix predicted by TMHMM2.0 229193014383 probable transmembrane helix predicted by TMHMM2.0 229193014384 probable transmembrane helix predicted by TMHMM2.0 229193014385 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 229193014386 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193014387 Walker A/P-loop; other site 229193014388 ATP binding site [chemical binding]; other site 229193014389 Q-loop/lid; other site 229193014390 ABC transporter signature motif; other site 229193014391 Walker B; other site 229193014392 D-loop; other site 229193014393 H-loop/switch region; other site 229193014394 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193014395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 229193014396 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 229193014397 dimerization interface [polypeptide binding]; other site 229193014398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193014399 dimer interface [polypeptide binding]; other site 229193014400 phosphorylation site [posttranslational modification] 229193014401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193014402 ATP binding site [chemical binding]; other site 229193014403 Mg2+ binding site [ion binding]; other site 229193014404 G-X-G motif; other site 229193014405 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 229193014406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193014407 active site 229193014408 phosphorylation site [posttranslational modification] 229193014409 intermolecular recognition site; other site 229193014410 dimerization interface [polypeptide binding]; other site 229193014411 probable transmembrane helix predicted by TMHMM2.0 229193014412 probable transmembrane helix predicted by TMHMM2.0 229193014413 Predicted flavoproteins [General function prediction only]; Region: COG2081 229193014414 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 229193014415 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 229193014416 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 229193014417 probable transmembrane helix predicted by TMHMM2.0 229193014418 probable transmembrane helix predicted by TMHMM2.0 229193014419 probable transmembrane helix predicted by TMHMM2.0 229193014420 probable transmembrane helix predicted by TMHMM2.0 229193014421 probable transmembrane helix predicted by TMHMM2.0 229193014422 probable transmembrane helix predicted by TMHMM2.0 229193014423 probable transmembrane helix predicted by TMHMM2.0 229193014424 probable transmembrane helix predicted by TMHMM2.0 229193014425 probable transmembrane helix predicted by TMHMM2.0 229193014426 probable transmembrane helix predicted by TMHMM2.0 229193014427 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193014428 universal stress protein UspB; Provisional; Region: PRK04960 229193014429 probable transmembrane helix predicted by TMHMM2.0 229193014430 probable transmembrane helix predicted by TMHMM2.0 229193014431 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 229193014432 Ligand Binding Site [chemical binding]; other site 229193014433 BlastProDom match to entry PD016172 sp_P28242_USPA_ECOLI, E-value 2e-28 229193014434 glutamate dehydrogenase; Provisional; Region: PRK09414 229193014435 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 229193014436 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 229193014437 NAD(P) binding site [chemical binding]; other site 229193014438 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 229193014439 active site 229193014440 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 229193014441 putative methyltransferase; Provisional; Region: PRK10742 229193014442 HMMPfam match to entry PF04445 DUF548, E-value 1.2e-154 229193014443 oligopeptidase A; Provisional; Region: PRK10911 229193014444 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 229193014445 active site 229193014446 Zn binding site [ion binding]; other site 229193014447 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 229193014448 BlastProDom match to entry PD039938 sp_P37634_YHIR_ECOLI, E-value e-115 229193014449 HMMPfam match to entry PF04378 DUF519, E-value 1.7e-153 229193014450 glutathione reductase; Validated; Region: PRK06116 229193014451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 229193014452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 229193014453 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 229193014454 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 229193014455 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 229193014456 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 229193014457 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 229193014458 fructuronate transporter; Provisional; Region: PRK10034; cl15264 229193014459 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 229193014460 probable transmembrane helix predicted by TMHMM2.0 229193014461 probable transmembrane helix predicted by TMHMM2.0 229193014462 probable transmembrane helix predicted by TMHMM2.0 229193014463 probable transmembrane helix predicted by TMHMM2.0 229193014464 probable transmembrane helix predicted by TMHMM2.0 229193014465 probable transmembrane helix predicted by TMHMM2.0 229193014466 probable transmembrane helix predicted by TMHMM2.0 229193014467 probable transmembrane helix predicted by TMHMM2.0 229193014468 probable transmembrane helix predicted by TMHMM2.0 229193014469 probable transmembrane helix predicted by TMHMM2.0 229193014470 probable transmembrane helix predicted by TMHMM2.0 229193014471 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 229193014472 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 229193014473 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 229193014474 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 229193014475 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 229193014476 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 229193014477 Autotransporter beta-domain; Region: Autotransporter; smart00869 229193014478 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 229193014479 probable transmembrane helix predicted by TMHMM2.0 229193014480 probable transmembrane helix predicted by TMHMM2.0 229193014481 probable transmembrane helix predicted by TMHMM2.0 229193014482 probable transmembrane helix predicted by TMHMM2.0 229193014483 probable transmembrane helix predicted by TMHMM2.0 229193014484 probable transmembrane helix predicted by TMHMM2.0 229193014485 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 229193014486 probable transmembrane helix predicted by TMHMM2.0 229193014487 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 229193014488 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 229193014489 HMMPfam match to entry PF05170 AsmA, E-value 4e-170 229193014490 probable transmembrane helix predicted by TMHMM2.0 229193014491 ProfileScan match to entry PS50325 THR_RICH, E-value 10.061 229193014492 probable transmembrane helix predicted by TMHMM2.0 229193014493 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 229193014494 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 229193014495 active site 1 [active] 229193014496 dimer interface [polypeptide binding]; other site 229193014497 hexamer interface [polypeptide binding]; other site 229193014498 active site 2 [active] 229193014499 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 229193014500 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 229193014501 substrate binding site [chemical binding]; other site 229193014502 ATP binding site [chemical binding]; other site 229193014503 BlastProDom match to entry PD023180 sp_P37647_KDGK_ECOLI, E-value 5e-30 229193014504 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 229193014505 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 229193014506 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 229193014507 HMMPfam match to entry PF05193 Peptidase_M16_C, E-value 3.4e-17 229193014508 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 229193014509 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 229193014510 probable transmembrane helix predicted by TMHMM2.0 229193014511 probable transmembrane helix predicted by TMHMM2.0 229193014512 probable transmembrane helix predicted by TMHMM2.0 229193014513 probable transmembrane helix predicted by TMHMM2.0 229193014514 probable transmembrane helix predicted by TMHMM2.0 229193014515 probable transmembrane helix predicted by TMHMM2.0 229193014516 probable transmembrane helix predicted by TMHMM2.0 229193014517 probable transmembrane helix predicted by TMHMM2.0 229193014518 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 229193014519 sugar binding site [chemical binding]; other site 229193014520 probable transmembrane helix predicted by TMHMM2.0 229193014521 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 229193014522 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 229193014523 biofilm formation regulator HmsP; Provisional; Region: PRK11829 229193014524 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 229193014525 metal binding site [ion binding]; metal-binding site 229193014526 active site 229193014527 I-site; other site 229193014528 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 229193014529 probable transmembrane helix predicted by TMHMM2.0 229193014530 probable transmembrane helix predicted by TMHMM2.0 229193014531 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 229193014532 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193014533 Walker A/P-loop; other site 229193014534 ATP binding site [chemical binding]; other site 229193014535 Q-loop/lid; other site 229193014536 ABC transporter signature motif; other site 229193014537 Walker B; other site 229193014538 D-loop; other site 229193014539 H-loop/switch region; other site 229193014540 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 229193014541 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 229193014542 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 229193014543 Walker A/P-loop; other site 229193014544 ATP binding site [chemical binding]; other site 229193014545 Q-loop/lid; other site 229193014546 ABC transporter signature motif; other site 229193014547 Walker B; other site 229193014548 D-loop; other site 229193014549 H-loop/switch region; other site 229193014550 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 229193014551 dipeptide transporter; Provisional; Region: PRK10913 229193014552 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 229193014553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193014554 dimer interface [polypeptide binding]; other site 229193014555 conserved gate region; other site 229193014556 putative PBP binding loops; other site 229193014557 ABC-ATPase subunit interface; other site 229193014558 probable transmembrane helix predicted by TMHMM2.0 229193014559 probable transmembrane helix predicted by TMHMM2.0 229193014560 probable transmembrane helix predicted by TMHMM2.0 229193014561 probable transmembrane helix predicted by TMHMM2.0 229193014562 probable transmembrane helix predicted by TMHMM2.0 229193014563 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 229193014564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193014565 dimer interface [polypeptide binding]; other site 229193014566 conserved gate region; other site 229193014567 putative PBP binding loops; other site 229193014568 ABC-ATPase subunit interface; other site 229193014569 probable transmembrane helix predicted by TMHMM2.0 229193014570 probable transmembrane helix predicted by TMHMM2.0 229193014571 probable transmembrane helix predicted by TMHMM2.0 229193014572 probable transmembrane helix predicted by TMHMM2.0 229193014573 probable transmembrane helix predicted by TMHMM2.0 229193014574 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 229193014575 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 229193014576 peptide binding site [polypeptide binding]; other site 229193014577 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 229193014578 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 229193014579 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 229193014580 probable transmembrane helix predicted by TMHMM2.0 229193014581 haemagglutination activity domain; Region: Haemagg_act; pfam05860 229193014582 probable transmembrane helix predicted by TMHMM2.0 229193014583 regulatory protein UhpC; Provisional; Region: PRK11663 229193014584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193014585 putative substrate translocation pore; other site 229193014586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193014587 probable transmembrane helix predicted by TMHMM2.0 229193014588 probable transmembrane helix predicted by TMHMM2.0 229193014589 probable transmembrane helix predicted by TMHMM2.0 229193014590 probable transmembrane helix predicted by TMHMM2.0 229193014591 probable transmembrane helix predicted by TMHMM2.0 229193014592 probable transmembrane helix predicted by TMHMM2.0 229193014593 BlastProDom match to entry PD003807 sp_Q9CLA1_Q9CLA1_PASMU, E-value 8e-42 229193014594 probable transmembrane helix predicted by TMHMM2.0 229193014595 probable transmembrane helix predicted by TMHMM2.0 229193014596 probable transmembrane helix predicted by TMHMM2.0 229193014597 probable transmembrane helix predicted by TMHMM2.0 229193014598 sensory histidine kinase UhpB; Provisional; Region: PRK11644 229193014599 MASE1; Region: MASE1; pfam05231 229193014600 Histidine kinase; Region: HisKA_3; pfam07730 229193014601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193014602 ATP binding site [chemical binding]; other site 229193014603 Mg2+ binding site [ion binding]; other site 229193014604 G-X-G motif; other site 229193014605 ProfileScan match to entry PS50319 LEU_RICH, E-value 12.479 229193014606 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 229193014607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193014608 active site 229193014609 phosphorylation site [posttranslational modification] 229193014610 intermolecular recognition site; other site 229193014611 dimerization interface [polypeptide binding]; other site 229193014612 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193014613 DNA binding residues [nucleotide binding] 229193014614 dimerization interface [polypeptide binding]; other site 229193014615 phosphoethanolamine transferase; Provisional; Region: PRK11560 229193014616 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 229193014617 Sulfatase; Region: Sulfatase; pfam00884 229193014618 probable transmembrane helix predicted by TMHMM2.0 229193014619 probable transmembrane helix predicted by TMHMM2.0 229193014620 probable transmembrane helix predicted by TMHMM2.0 229193014621 probable transmembrane helix predicted by TMHMM2.0 229193014622 probable transmembrane helix predicted by TMHMM2.0 229193014623 Yersinia protein of unknown function (DUF3831); Region: DUF3831; pfam12908 229193014624 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 229193014625 probable transmembrane helix predicted by TMHMM2.0 229193014626 highly similar to Yersinia pestis CO92 YPO4015 and Yersinia pestis KIM proY; disrupted by IS100 element 229193014627 transposase/IS protein; Provisional; Region: PRK09183 229193014628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193014629 Walker A motif; other site 229193014630 ATP binding site [chemical binding]; other site 229193014631 Walker B motif; other site 229193014632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193014633 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193014634 DNA-binding interface [nucleotide binding]; DNA binding site 229193014635 Integrase core domain; Region: rve; pfam00665 229193014636 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 229193014637 active sites [active] 229193014638 tetramer interface [polypeptide binding]; other site 229193014639 urocanate hydratase; Provisional; Region: PRK05414 229193014640 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 229193014641 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 229193014642 dimer interface [polypeptide binding]; other site 229193014643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193014644 catalytic residue [active] 229193014645 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 229193014646 active site 229193014647 probable transmembrane helix predicted by TMHMM2.0 229193014648 probable transmembrane helix predicted by TMHMM2.0 229193014649 probable transmembrane helix predicted by TMHMM2.0 229193014650 probable transmembrane helix predicted by TMHMM2.0 229193014651 probable transmembrane helix predicted by TMHMM2.0 229193014652 probable transmembrane helix predicted by TMHMM2.0 229193014653 probable transmembrane helix predicted by TMHMM2.0 229193014654 probable transmembrane helix predicted by TMHMM2.0 229193014655 probable transmembrane helix predicted by TMHMM2.0 229193014656 probable transmembrane helix predicted by TMHMM2.0 229193014657 hypothetical protein; Provisional; Region: PRK07206 229193014658 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 229193014659 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 229193014660 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 229193014661 putative ligand binding residues [chemical binding]; other site 229193014662 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 229193014663 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193014664 ABC-ATPase subunit interface; other site 229193014665 dimer interface [polypeptide binding]; other site 229193014666 putative PBP binding regions; other site 229193014667 probable transmembrane helix predicted by TMHMM2.0 229193014668 probable transmembrane helix predicted by TMHMM2.0 229193014669 probable transmembrane helix predicted by TMHMM2.0 229193014670 probable transmembrane helix predicted by TMHMM2.0 229193014671 probable transmembrane helix predicted by TMHMM2.0 229193014672 probable transmembrane helix predicted by TMHMM2.0 229193014673 probable transmembrane helix predicted by TMHMM2.0 229193014674 probable transmembrane helix predicted by TMHMM2.0 229193014675 probable transmembrane helix predicted by TMHMM2.0 229193014676 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 229193014677 ABC-ATPase subunit interface; other site 229193014678 dimer interface [polypeptide binding]; other site 229193014679 putative PBP binding regions; other site 229193014680 probable transmembrane helix predicted by TMHMM2.0 229193014681 probable transmembrane helix predicted by TMHMM2.0 229193014682 probable transmembrane helix predicted by TMHMM2.0 229193014683 probable transmembrane helix predicted by TMHMM2.0 229193014684 probable transmembrane helix predicted by TMHMM2.0 229193014685 probable transmembrane helix predicted by TMHMM2.0 229193014686 probable transmembrane helix predicted by TMHMM2.0 229193014687 probable transmembrane helix predicted by TMHMM2.0 229193014688 probable transmembrane helix predicted by TMHMM2.0 229193014689 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 229193014690 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 229193014691 Walker A/P-loop; other site 229193014692 ATP binding site [chemical binding]; other site 229193014693 Q-loop/lid; other site 229193014694 ABC transporter signature motif; other site 229193014695 Walker B; other site 229193014696 D-loop; other site 229193014697 H-loop/switch region; other site 229193014698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 229193014699 non-specific DNA binding site [nucleotide binding]; other site 229193014700 salt bridge; other site 229193014701 sequence-specific DNA binding site [nucleotide binding]; other site 229193014702 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 229193014703 HMMPfam match to entry PF04606 Ogr_Delta, E-value 2.4e-30 229193014704 integrase; Provisional; Region: PRK09692 229193014705 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 229193014706 active site 229193014707 Int/Topo IB signature motif; other site 229193014708 probable transmembrane helix predicted by TMHMM2.0 229193014709 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 229193014710 putative dimerization interface [polypeptide binding]; other site 229193014711 Transcriptional regulators [Transcription]; Region: PurR; COG1609 229193014712 putative ligand binding site [chemical binding]; other site 229193014713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193014714 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 229193014715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193014716 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 229193014717 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193014718 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193014719 TM-ABC transporter signature motif; other site 229193014720 probable transmembrane helix predicted by TMHMM2.0 229193014721 probable transmembrane helix predicted by TMHMM2.0 229193014722 probable transmembrane helix predicted by TMHMM2.0 229193014723 probable transmembrane helix predicted by TMHMM2.0 229193014724 probable transmembrane helix predicted by TMHMM2.0 229193014725 probable transmembrane helix predicted by TMHMM2.0 229193014726 probable transmembrane helix predicted by TMHMM2.0 229193014727 probable transmembrane helix predicted by TMHMM2.0 229193014728 probable transmembrane helix predicted by TMHMM2.0 229193014729 probable transmembrane helix predicted by TMHMM2.0 229193014730 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 229193014731 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193014732 Walker A/P-loop; other site 229193014733 ATP binding site [chemical binding]; other site 229193014734 Q-loop/lid; other site 229193014735 ABC transporter signature motif; other site 229193014736 Walker B; other site 229193014737 D-loop; other site 229193014738 H-loop/switch region; other site 229193014739 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193014740 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 229193014741 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 229193014742 putative ligand binding site [chemical binding]; other site 229193014743 xylose isomerase; Provisional; Region: PRK05474 229193014744 xylose isomerase; Region: xylose_isom_A; TIGR02630 229193014745 BlastProDom match to entry PD003353 sp_P00944_XYLA_ECOLI, E-value 0.0 229193014746 xylulokinase; Provisional; Region: PRK15027 229193014747 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 229193014748 N- and C-terminal domain interface [polypeptide binding]; other site 229193014749 active site 229193014750 MgATP binding site [chemical binding]; other site 229193014751 catalytic site [active] 229193014752 metal binding site [ion binding]; metal-binding site 229193014753 xylulose binding site [chemical binding]; other site 229193014754 homodimer interface [polypeptide binding]; other site 229193014755 Fimbrial protein; Region: Fimbrial; pfam00419 229193014756 probable transmembrane helix predicted by TMHMM2.0 229193014757 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 229193014758 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193014759 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 229193014760 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 229193014761 PapC C-terminal domain; Region: PapC_C; pfam13953 229193014762 PapC N-terminal domain; Region: PapC_N; pfam13954 229193014763 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 229193014764 probable transmembrane helix predicted by TMHMM2.0 229193014765 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 229193014766 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 229193014767 Acyltransferase family; Region: Acyl_transf_3; pfam01757 229193014768 probable transmembrane helix predicted by TMHMM2.0 229193014769 probable transmembrane helix predicted by TMHMM2.0 229193014770 probable transmembrane helix predicted by TMHMM2.0 229193014771 probable transmembrane helix predicted by TMHMM2.0 229193014772 probable transmembrane helix predicted by TMHMM2.0 229193014773 probable transmembrane helix predicted by TMHMM2.0 229193014774 probable transmembrane helix predicted by TMHMM2.0 229193014775 probable transmembrane helix predicted by TMHMM2.0 229193014776 probable transmembrane helix predicted by TMHMM2.0 229193014777 probable transmembrane helix predicted by TMHMM2.0 229193014778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 229193014779 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193014780 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193014781 probable transmembrane helix predicted by TMHMM2.0 229193014782 putative transposase OrfB; Reviewed; Region: PHA02517 229193014783 HTH-like domain; Region: HTH_21; pfam13276 229193014784 Integrase core domain; Region: rve; pfam00665 229193014785 Integrase core domain; Region: rve_2; pfam13333 229193014786 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 229193014787 PAS domain S-box; Region: sensory_box; TIGR00229 229193014788 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 229193014789 putative active site [active] 229193014790 heme pocket [chemical binding]; other site 229193014791 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 229193014792 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 229193014793 metal binding site [ion binding]; metal-binding site 229193014794 active site 229193014795 I-site; other site 229193014796 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 229193014797 probable transmembrane helix predicted by TMHMM2.0 229193014798 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 229193014799 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 229193014800 probable transmembrane helix predicted by TMHMM2.0 229193014801 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 229193014802 probable transmembrane helix predicted by TMHMM2.0 229193014803 probable transmembrane helix predicted by TMHMM2.0 229193014804 probable transmembrane helix predicted by TMHMM2.0 229193014805 probable transmembrane helix predicted by TMHMM2.0 229193014806 probable transmembrane helix predicted by TMHMM2.0 229193014807 probable transmembrane helix predicted by TMHMM2.0 229193014808 probable transmembrane helix predicted by TMHMM2.0 229193014809 probable transmembrane helix predicted by TMHMM2.0 229193014810 probable transmembrane helix predicted by TMHMM2.0 229193014811 probable transmembrane helix predicted by TMHMM2.0 229193014812 probable transmembrane helix predicted by TMHMM2.0 229193014813 probable transmembrane helix predicted by TMHMM2.0 229193014814 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 229193014815 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 229193014816 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 229193014817 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 229193014818 Autotransporter beta-domain; Region: Autotransporter; pfam03797 229193014819 ProfileScan match to entry PS50315 GLY_RICH, E-value 8.634 229193014820 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 229193014821 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 229193014822 ProfileScan match to entry PS50319 LEU_RICH, E-value 11.338 229193014823 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.24 229193014824 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.21 229193014825 HMMSmart match to entry SM00364 LRR_BAC, E-value 1.2 229193014826 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.00094 229193014827 HMMSmart match to entry SM00364 LRR_BAC, E-value 10 229193014828 HMMSmart match to entry SM00364 LRR_BAC, E-value 4.8e+02 229193014829 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.0046 229193014830 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.00046 229193014831 HMMSmart match to entry SM00364 LRR_BAC, E-value 5.4e+02 229193014832 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 229193014833 ProfileScan match to entry PS50319 LEU_RICH, E-value 10.054 229193014834 HMMSmart match to entry SM00364 LRR_BAC, E-value 6.1 229193014835 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.0094 229193014836 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.015 229193014837 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.48 229193014838 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.68 229193014839 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.019 229193014840 HMMSmart match to entry SM00364 LRR_BAC, E-value 1e+02 229193014841 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 229193014842 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 229193014843 HMMSmart match to entry SM00364 LRR_BAC, E-value 1.2 229193014844 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.061 229193014845 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.0027 229193014846 HMMSmart match to entry SM00364 LRR_BAC, E-value 2.7 229193014847 HMMSmart match to entry SM00364 LRR_BAC, E-value 5.3e+02 229193014848 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.0046 229193014849 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.06 229193014850 HMMSmart match to entry SM00364 LRR_BAC, E-value 1.6e+02 229193014851 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 229193014852 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 229193014853 probable transmembrane helix predicted by TMHMM2.0 229193014854 probable transmembrane helix predicted by TMHMM2.0 229193014855 probable transmembrane helix predicted by TMHMM2.0 229193014856 probable transmembrane helix predicted by TMHMM2.0 229193014857 probable transmembrane helix predicted by TMHMM2.0 229193014858 probable transmembrane helix predicted by TMHMM2.0 229193014859 probable transmembrane helix predicted by TMHMM2.0 229193014860 probable transmembrane helix predicted by TMHMM2.0 229193014861 probable transmembrane helix predicted by TMHMM2.0 229193014862 probable transmembrane helix predicted by TMHMM2.0 229193014863 probable transmembrane helix predicted by TMHMM2.0 229193014864 probable transmembrane helix predicted by TMHMM2.0 229193014865 probable transmembrane helix predicted by TMHMM2.0 229193014866 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 229193014867 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 229193014868 metal binding site [ion binding]; metal-binding site 229193014869 dimer interface [polypeptide binding]; other site 229193014870 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 229193014871 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 229193014872 N-terminal plug; other site 229193014873 ligand-binding site [chemical binding]; other site 229193014874 acyl-CoA synthetase; Validated; Region: PRK05850 229193014875 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 229193014876 acyl-activating enzyme (AAE) consensus motif; other site 229193014877 active site 229193014878 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 229193014879 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 229193014880 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 229193014881 active site 229193014882 Condensation domain; Region: Condensation; pfam00668 229193014883 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 229193014884 Nonribosomal peptide synthase; Region: NRPS; pfam08415 229193014885 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 229193014886 acyl-activating enzyme (AAE) consensus motif; other site 229193014887 AMP binding site [chemical binding]; other site 229193014888 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 229193014889 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 229193014890 Condensation domain; Region: Condensation; pfam00668 229193014891 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 229193014892 Nonribosomal peptide synthase; Region: NRPS; pfam08415 229193014893 probable transmembrane helix predicted by TMHMM2.0 229193014894 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 229193014895 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 229193014896 acyl-activating enzyme (AAE) consensus motif; other site 229193014897 AMP binding site [chemical binding]; other site 229193014898 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 229193014899 Condensation domain; Region: Condensation; pfam00668 229193014900 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 229193014901 Nonribosomal peptide synthase; Region: NRPS; pfam08415 229193014902 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 229193014903 acyl-activating enzyme (AAE) consensus motif; other site 229193014904 AMP binding site [chemical binding]; other site 229193014905 Methyltransferase domain; Region: Methyltransf_31; pfam13847 229193014906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193014907 S-adenosylmethionine binding site [chemical binding]; other site 229193014908 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 229193014909 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 229193014910 Thioesterase domain; Region: Thioesterase; pfam00975 229193014911 ProfileScan match to entry PS50322 GLN_RICH, E-value 15.174 229193014912 ProfileScan match to entry PS50325 THR_RICH, E-value 19.144 229193014913 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 229193014914 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 229193014915 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 229193014916 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 229193014917 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 229193014918 muropeptide transporter; Validated; Region: ampG; cl17669 229193014919 probable transmembrane helix predicted by TMHMM2.0 229193014920 probable transmembrane helix predicted by TMHMM2.0 229193014921 probable transmembrane helix predicted by TMHMM2.0 229193014922 probable transmembrane helix predicted by TMHMM2.0 229193014923 probable transmembrane helix predicted by TMHMM2.0 229193014924 probable transmembrane helix predicted by TMHMM2.0 229193014925 probable transmembrane helix predicted by TMHMM2.0 229193014926 probable transmembrane helix predicted by TMHMM2.0 229193014927 probable transmembrane helix predicted by TMHMM2.0 229193014928 probable transmembrane helix predicted by TMHMM2.0 229193014929 probable transmembrane helix predicted by TMHMM2.0 229193014930 probable transmembrane helix predicted by TMHMM2.0 229193014931 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 229193014932 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 229193014933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193014934 Walker A/P-loop; other site 229193014935 ATP binding site [chemical binding]; other site 229193014936 Q-loop/lid; other site 229193014937 ABC transporter signature motif; other site 229193014938 Walker B; other site 229193014939 D-loop; other site 229193014940 H-loop/switch region; other site 229193014941 probable transmembrane helix predicted by TMHMM2.0 229193014942 probable transmembrane helix predicted by TMHMM2.0 229193014943 probable transmembrane helix predicted by TMHMM2.0 229193014944 probable transmembrane helix predicted by TMHMM2.0 229193014945 probable transmembrane helix predicted by TMHMM2.0 229193014946 probable transmembrane helix predicted by TMHMM2.0 229193014947 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 229193014948 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 229193014949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193014950 Walker A/P-loop; other site 229193014951 ATP binding site [chemical binding]; other site 229193014952 Q-loop/lid; other site 229193014953 ABC transporter signature motif; other site 229193014954 Walker B; other site 229193014955 D-loop; other site 229193014956 H-loop/switch region; other site 229193014957 probable transmembrane helix predicted by TMHMM2.0 229193014958 probable transmembrane helix predicted by TMHMM2.0 229193014959 probable transmembrane helix predicted by TMHMM2.0 229193014960 probable transmembrane helix predicted by TMHMM2.0 229193014961 probable transmembrane helix predicted by TMHMM2.0 229193014962 probable transmembrane helix predicted by TMHMM2.0 229193014963 fructuronate transporter; Provisional; Region: PRK10034 229193014964 gluconate transporter; Region: gntP; TIGR00791 229193014965 probable transmembrane helix predicted by TMHMM2.0 229193014966 probable transmembrane helix predicted by TMHMM2.0 229193014967 probable transmembrane helix predicted by TMHMM2.0 229193014968 probable transmembrane helix predicted by TMHMM2.0 229193014969 probable transmembrane helix predicted by TMHMM2.0 229193014970 probable transmembrane helix predicted by TMHMM2.0 229193014971 probable transmembrane helix predicted by TMHMM2.0 229193014972 probable transmembrane helix predicted by TMHMM2.0 229193014973 probable transmembrane helix predicted by TMHMM2.0 229193014974 probable transmembrane helix predicted by TMHMM2.0 229193014975 probable transmembrane helix predicted by TMHMM2.0 229193014976 probable transmembrane helix predicted by TMHMM2.0 229193014977 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 229193014978 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 229193014979 Autotransporter beta-domain; Region: Autotransporter; smart00869 229193014980 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 229193014981 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 229193014982 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 229193014983 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 229193014984 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 229193014985 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 229193014986 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 229193014987 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 229193014988 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 229193014989 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 229193014990 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 229193014991 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 229193014992 RHS Repeat; Region: RHS_repeat; pfam05593 229193014993 RHS Repeat; Region: RHS_repeat; cl11982 229193014994 RHS protein; Region: RHS; pfam03527 229193014995 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 229193014996 ProfileScan match to entry PS50322 GLN_RICH, E-value 8.625 229193014997 hypothetical protein; Provisional; Region: PRK10039 229193014998 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 229193014999 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 229193015000 transmembrane helices; other site 229193015001 probable transmembrane helix predicted by TMHMM2.0 229193015002 probable transmembrane helix predicted by TMHMM2.0 229193015003 probable transmembrane helix predicted by TMHMM2.0 229193015004 probable transmembrane helix predicted by TMHMM2.0 229193015005 probable transmembrane helix predicted by TMHMM2.0 229193015006 probable transmembrane helix predicted by TMHMM2.0 229193015007 probable transmembrane helix predicted by TMHMM2.0 229193015008 probable transmembrane helix predicted by TMHMM2.0 229193015009 probable transmembrane helix predicted by TMHMM2.0 229193015010 probable transmembrane helix predicted by TMHMM2.0 229193015011 probable transmembrane helix predicted by TMHMM2.0 229193015012 probable transmembrane helix predicted by TMHMM2.0 229193015013 probable transmembrane helix predicted by TMHMM2.0 229193015014 probable transmembrane helix predicted by TMHMM2.0 229193015015 Transcriptional regulators [Transcription]; Region: PurR; COG1609 229193015016 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193015017 DNA binding site [nucleotide binding] 229193015018 domain linker motif; other site 229193015019 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 229193015020 putative dimerization interface [polypeptide binding]; other site 229193015021 putative ligand binding site [chemical binding]; other site 229193015022 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 229193015023 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 229193015024 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 229193015025 probable transmembrane helix predicted by TMHMM2.0 229193015026 probable transmembrane helix predicted by TMHMM2.0 229193015027 probable transmembrane helix predicted by TMHMM2.0 229193015028 probable transmembrane helix predicted by TMHMM2.0 229193015029 probable transmembrane helix predicted by TMHMM2.0 229193015030 probable transmembrane helix predicted by TMHMM2.0 229193015031 probable transmembrane helix predicted by TMHMM2.0 229193015032 probable transmembrane helix predicted by TMHMM2.0 229193015033 probable transmembrane helix predicted by TMHMM2.0 229193015034 probable transmembrane helix predicted by TMHMM2.0 229193015035 probable transmembrane helix predicted by TMHMM2.0 229193015036 probable transmembrane helix predicted by TMHMM2.0 229193015037 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 229193015038 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 229193015039 N-terminal plug; other site 229193015040 ligand-binding site [chemical binding]; other site 229193015041 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 229193015042 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 229193015043 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 229193015044 IucA / IucC family; Region: IucA_IucC; pfam04183 229193015045 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 229193015046 HMMPfam match to entry PF04183 IucA_IucC, E-value 1.5e-158 229193015047 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 229193015048 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 229193015049 HMMPfam match to entry PF04183 IucA_IucC, E-value 1.4e-65 229193015050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193015051 Major Facilitator Superfamily; Region: MFS_1; pfam07690 229193015052 putative substrate translocation pore; other site 229193015053 probable transmembrane helix predicted by TMHMM2.0 229193015054 probable transmembrane helix predicted by TMHMM2.0 229193015055 probable transmembrane helix predicted by TMHMM2.0 229193015056 probable transmembrane helix predicted by TMHMM2.0 229193015057 probable transmembrane helix predicted by TMHMM2.0 229193015058 probable transmembrane helix predicted by TMHMM2.0 229193015059 probable transmembrane helix predicted by TMHMM2.0 229193015060 probable transmembrane helix predicted by TMHMM2.0 229193015061 probable transmembrane helix predicted by TMHMM2.0 229193015062 probable transmembrane helix predicted by TMHMM2.0 229193015063 probable transmembrane helix predicted by TMHMM2.0 229193015064 probable transmembrane helix predicted by TMHMM2.0 229193015065 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 229193015066 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 229193015067 putative active site [active] 229193015068 Predicted peptidase [General function prediction only]; Region: COG4099 229193015069 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 229193015070 Autoinducer binding domain; Region: Autoind_bind; pfam03472 229193015071 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 229193015072 DNA binding residues [nucleotide binding] 229193015073 dimerization interface [polypeptide binding]; other site 229193015074 Autoinducer synthetase; Region: Autoind_synth; pfam00765 229193015075 CAAX protease self-immunity; Region: Abi; pfam02517 229193015076 probable transmembrane helix predicted by TMHMM2.0 229193015077 probable transmembrane helix predicted by TMHMM2.0 229193015078 probable transmembrane helix predicted by TMHMM2.0 229193015079 probable transmembrane helix predicted by TMHMM2.0 229193015080 probable transmembrane helix predicted by TMHMM2.0 229193015081 probable transmembrane helix predicted by TMHMM2.0 229193015082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 229193015083 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 229193015084 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 229193015085 probable transmembrane helix predicted by TMHMM2.0 229193015086 probable transmembrane helix predicted by TMHMM2.0 229193015087 probable transmembrane helix predicted by TMHMM2.0 229193015088 probable transmembrane helix predicted by TMHMM2.0 229193015089 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 229193015090 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 229193015091 Protein of unknown function (DUF877); Region: DUF877; pfam05943 229193015092 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 229193015093 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 229193015094 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 229193015095 probable transmembrane helix predicted by TMHMM2.0 229193015096 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 229193015097 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 229193015098 ligand binding site [chemical binding]; other site 229193015099 probable transmembrane helix predicted by TMHMM2.0 229193015100 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 229193015101 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 229193015102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193015103 Walker A motif; other site 229193015104 ATP binding site [chemical binding]; other site 229193015105 Walker B motif; other site 229193015106 arginine finger; other site 229193015107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193015108 Walker A motif; other site 229193015109 ATP binding site [chemical binding]; other site 229193015110 Walker B motif; other site 229193015111 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 229193015112 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 229193015113 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 229193015114 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 229193015115 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 229193015116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 229193015117 Peptidase family M23; Region: Peptidase_M23; pfam01551 229193015118 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 229193015119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 229193015120 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 229193015121 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 229193015122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 229193015123 Peptidase family M23; Region: Peptidase_M23; pfam01551 229193015124 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 229193015125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 229193015126 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 229193015127 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 229193015128 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 229193015129 ornithine decarboxylase; Provisional; Region: PRK13578 229193015130 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 229193015131 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 229193015132 homodimer interface [polypeptide binding]; other site 229193015133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193015134 catalytic residue [active] 229193015135 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 229193015136 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 229193015137 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 229193015138 putative ligand binding site [chemical binding]; other site 229193015139 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 229193015140 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193015141 Walker A/P-loop; other site 229193015142 ATP binding site [chemical binding]; other site 229193015143 Q-loop/lid; other site 229193015144 ABC transporter signature motif; other site 229193015145 Walker B; other site 229193015146 D-loop; other site 229193015147 H-loop/switch region; other site 229193015148 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193015149 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193015150 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193015151 TM-ABC transporter signature motif; other site 229193015152 probable transmembrane helix predicted by TMHMM2.0 229193015153 probable transmembrane helix predicted by TMHMM2.0 229193015154 probable transmembrane helix predicted by TMHMM2.0 229193015155 probable transmembrane helix predicted by TMHMM2.0 229193015156 probable transmembrane helix predicted by TMHMM2.0 229193015157 probable transmembrane helix predicted by TMHMM2.0 229193015158 probable transmembrane helix predicted by TMHMM2.0 229193015159 probable transmembrane helix predicted by TMHMM2.0 229193015160 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 229193015161 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 229193015162 N-terminal plug; other site 229193015163 ligand-binding site [chemical binding]; other site 229193015164 probable transmembrane helix predicted by TMHMM2.0 229193015165 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 229193015166 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 229193015167 putative ligand binding residues [chemical binding]; other site 229193015168 murein transglycosylase C; Provisional; Region: mltC; PRK11671 229193015169 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 229193015170 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 229193015171 N-acetyl-D-glucosamine binding site [chemical binding]; other site 229193015172 catalytic residue [active] 229193015173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924 229193015174 HMMPfam match to entry PF04362 DUF495, E-value 9.1e-66 229193015175 adenine DNA glycosylase; Provisional; Region: PRK10880 229193015176 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 229193015177 minor groove reading motif; other site 229193015178 helix-hairpin-helix signature motif; other site 229193015179 substrate binding pocket [chemical binding]; other site 229193015180 active site 229193015181 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 229193015182 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 229193015183 DNA binding and oxoG recognition site [nucleotide binding] 229193015184 probable transmembrane helix predicted by TMHMM2.0 229193015185 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 229193015186 hypothetical protein; Provisional; Region: PRK11702 229193015187 HMMPfam match to entry PF04320 DUF469, E-value 4.1e-75 229193015188 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 229193015189 glutaminase; Provisional; Region: PRK00971 229193015190 Peptidase C80 family; Region: Peptidase_C80; pfam11713 229193015191 Peptidase C80 family; Region: Peptidase_C80; pfam11713 229193015192 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 229193015193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193015194 MULE transposase domain; Region: MULE; pfam10551 229193015195 HemN family oxidoreductase; Provisional; Region: PRK05660 229193015196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193015197 FeS/SAM binding site; other site 229193015198 HemN C-terminal domain; Region: HemN_C; pfam06969 229193015199 HMMPfam match to entry PF04055 Radical_SAM, E-value 9.4e-24 229193015200 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 229193015201 active site 229193015202 dimerization interface [polypeptide binding]; other site 229193015203 hypothetical protein; Validated; Region: PRK05090 229193015204 YGGT family; Region: YGGT; pfam02325 229193015205 Predicted integral membrane protein [Function unknown]; Region: COG0762 229193015206 probable transmembrane helix predicted by TMHMM2.0 229193015207 probable transmembrane helix predicted by TMHMM2.0 229193015208 probable transmembrane helix predicted by TMHMM2.0 229193015209 probable transmembrane helix predicted by TMHMM2.0 229193015210 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 229193015211 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 229193015212 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 229193015213 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 229193015214 catalytic residue [active] 229193015215 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 229193015216 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 229193015217 Walker A motif; other site 229193015218 ATP binding site [chemical binding]; other site 229193015219 Walker B motif; other site 229193015220 agmatine deiminase; Provisional; Region: PRK13551 229193015221 agmatine deiminase; Region: agmatine_aguA; TIGR03380 229193015222 HMMPfam match to entry PF04371 PAD_porph, E-value 9.1e-178 229193015223 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 229193015224 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 229193015225 putative active site; other site 229193015226 catalytic triad [active] 229193015227 putative dimer interface [polypeptide binding]; other site 229193015228 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 229193015229 hypothetical protein; Validated; Region: PRK00228 229193015230 glutathione synthetase; Provisional; Region: PRK05246 229193015231 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 229193015232 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 229193015233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 229193015234 RNA methyltransferase, RsmE family; Region: TIGR00046 229193015235 DNA-specific endonuclease I; Provisional; Region: PRK15137 229193015236 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 229193015237 HMMPfam match to entry PF04231 Endonuclease_I, E-value 2e-129 229193015238 probable transmembrane helix predicted by TMHMM2.0 229193015239 hypothetical protein; Provisional; Region: PRK04860 229193015240 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 229193015241 BlastProDom match to entry PD034213 sp_P39902_SPRT_ECOLI, E-value 5e-59 229193015242 S-adenosylmethionine synthetase; Validated; Region: PRK05250 229193015243 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 229193015244 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 229193015245 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 229193015246 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 229193015247 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 229193015248 dimer interface [polypeptide binding]; other site 229193015249 active site 229193015250 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 229193015251 catalytic residues [active] 229193015252 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 229193015253 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 229193015254 [2Fe-2S] cluster binding site [ion binding]; other site 229193015255 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 229193015256 transketolase; Reviewed; Region: PRK12753 229193015257 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 229193015258 TPP-binding site [chemical binding]; other site 229193015259 dimer interface [polypeptide binding]; other site 229193015260 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 229193015261 PYR/PP interface [polypeptide binding]; other site 229193015262 dimer interface [polypeptide binding]; other site 229193015263 TPP binding site [chemical binding]; other site 229193015264 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 229193015265 probable transmembrane helix predicted by TMHMM2.0 229193015266 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193015267 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 229193015268 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 229193015269 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 229193015270 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 229193015271 Phosphoglycerate kinase; Region: PGK; pfam00162 229193015272 substrate binding site [chemical binding]; other site 229193015273 hinge regions; other site 229193015274 ADP binding site [chemical binding]; other site 229193015275 catalytic site [active] 229193015276 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 229193015277 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 229193015278 active site 229193015279 intersubunit interface [polypeptide binding]; other site 229193015280 zinc binding site [ion binding]; other site 229193015281 Na+ binding site [ion binding]; other site 229193015282 mechanosensitive channel MscS; Provisional; Region: PRK10334 229193015283 Conserved TM helix; Region: TM_helix; pfam05552 229193015284 Mechanosensitive ion channel; Region: MS_channel; pfam00924 229193015285 probable transmembrane helix predicted by TMHMM2.0 229193015286 probable transmembrane helix predicted by TMHMM2.0 229193015287 probable transmembrane helix predicted by TMHMM2.0 229193015288 probable transmembrane helix predicted by TMHMM2.0 229193015289 probable transmembrane helix predicted by TMHMM2.0 229193015290 probable transmembrane helix predicted by TMHMM2.0 229193015291 probable transmembrane helix predicted by TMHMM2.0 229193015292 transposase/IS protein; Provisional; Region: PRK09183 229193015293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193015294 Walker A motif; other site 229193015295 ATP binding site [chemical binding]; other site 229193015296 Walker B motif; other site 229193015297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193015298 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193015299 DNA-binding interface [nucleotide binding]; DNA binding site 229193015300 Integrase core domain; Region: rve; pfam00665 229193015301 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193015302 Sulfatase; Region: Sulfatase; cl17466 229193015303 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 229193015304 probable transmembrane helix predicted by TMHMM2.0 229193015305 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 229193015306 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 229193015307 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 229193015308 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 229193015309 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 229193015310 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 229193015311 dimer interface [polypeptide binding]; other site 229193015312 active site 229193015313 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 229193015314 putative active site [active] 229193015315 BlastProDom match to entry PD042108 sp_O50523_AGAS_STRCO, E-value 6e-37 229193015316 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 229193015317 active site 229193015318 phosphorylation site [posttranslational modification] 229193015319 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 229193015320 ProfileScan match to entry PS50321 ASN_RICH, E-value 8.658 229193015321 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 229193015322 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 229193015323 active pocket/dimerization site; other site 229193015324 active site 229193015325 phosphorylation site [posttranslational modification] 229193015326 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 229193015327 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 229193015328 active site 229193015329 dimer interface [polypeptide binding]; other site 229193015330 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481 229193015331 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 229193015332 NADP binding site [chemical binding]; other site 229193015333 homodimer interface [polypeptide binding]; other site 229193015334 active site 229193015335 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 229193015336 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 229193015337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193015338 FeS/SAM binding site; other site 229193015339 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 229193015340 HMMPfam match to entry PF04055 Radical_SAM, E-value 1.6e-17 229193015341 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 229193015342 Sulfatase; Region: Sulfatase; pfam00884 229193015343 probable transmembrane helix predicted by TMHMM2.0 229193015344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289 229193015345 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 229193015346 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 229193015347 intersubunit interface [polypeptide binding]; other site 229193015348 active site 229193015349 zinc binding site [ion binding]; other site 229193015350 Na+ binding site [ion binding]; other site 229193015351 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 229193015352 DJ-1 family protein; Region: not_thiJ; TIGR01383 229193015353 conserved cys residue [active] 229193015354 Transcriptional regulators [Transcription]; Region: PurR; COG1609 229193015355 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193015356 DNA binding site [nucleotide binding] 229193015357 domain linker motif; other site 229193015358 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 229193015359 dimerization interface [polypeptide binding]; other site 229193015360 ligand binding site [chemical binding]; other site 229193015361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193015362 D-galactonate transporter; Region: 2A0114; TIGR00893 229193015363 putative substrate translocation pore; other site 229193015364 probable transmembrane helix predicted by TMHMM2.0 229193015365 probable transmembrane helix predicted by TMHMM2.0 229193015366 probable transmembrane helix predicted by TMHMM2.0 229193015367 probable transmembrane helix predicted by TMHMM2.0 229193015368 probable transmembrane helix predicted by TMHMM2.0 229193015369 probable transmembrane helix predicted by TMHMM2.0 229193015370 probable transmembrane helix predicted by TMHMM2.0 229193015371 probable transmembrane helix predicted by TMHMM2.0 229193015372 probable transmembrane helix predicted by TMHMM2.0 229193015373 probable transmembrane helix predicted by TMHMM2.0 229193015374 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 229193015375 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 229193015376 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 229193015377 putative active site [active] 229193015378 putative catalytic site [active] 229193015379 lac repressor; Reviewed; Region: lacI; PRK09526 229193015380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193015381 DNA binding site [nucleotide binding] 229193015382 domain linker motif; other site 229193015383 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 229193015384 ligand binding site [chemical binding]; other site 229193015385 dimerization interface (open form) [polypeptide binding]; other site 229193015386 dimerization interface (closed form) [polypeptide binding]; other site 229193015387 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 229193015388 trimer interface; other site 229193015389 sugar binding site [chemical binding]; other site 229193015390 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 229193015391 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 229193015392 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 229193015393 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 229193015394 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 229193015395 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 229193015396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193015397 dimer interface [polypeptide binding]; other site 229193015398 conserved gate region; other site 229193015399 putative PBP binding loops; other site 229193015400 ABC-ATPase subunit interface; other site 229193015401 probable transmembrane helix predicted by TMHMM2.0 229193015402 probable transmembrane helix predicted by TMHMM2.0 229193015403 probable transmembrane helix predicted by TMHMM2.0 229193015404 probable transmembrane helix predicted by TMHMM2.0 229193015405 probable transmembrane helix predicted by TMHMM2.0 229193015406 probable transmembrane helix predicted by TMHMM2.0 229193015407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193015408 dimer interface [polypeptide binding]; other site 229193015409 conserved gate region; other site 229193015410 ABC-ATPase subunit interface; other site 229193015411 probable transmembrane helix predicted by TMHMM2.0 229193015412 probable transmembrane helix predicted by TMHMM2.0 229193015413 probable transmembrane helix predicted by TMHMM2.0 229193015414 probable transmembrane helix predicted by TMHMM2.0 229193015415 probable transmembrane helix predicted by TMHMM2.0 229193015416 probable transmembrane helix predicted by TMHMM2.0 229193015417 probable transmembrane helix predicted by TMHMM2.0 229193015418 probable transmembrane helix predicted by TMHMM2.0 229193015419 probable transmembrane helix predicted by TMHMM2.0 229193015420 probable transmembrane helix predicted by TMHMM2.0 229193015421 HMMPfam match to entry PF05154 TM2, E-value 1.9e-05 229193015422 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 229193015423 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 229193015424 DAK2 domain; Region: Dak2; cl03685 229193015425 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 229193015426 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 229193015427 Walker A/P-loop; other site 229193015428 ATP binding site [chemical binding]; other site 229193015429 Q-loop/lid; other site 229193015430 ABC transporter signature motif; other site 229193015431 Walker B; other site 229193015432 D-loop; other site 229193015433 H-loop/switch region; other site 229193015434 TOBE domain; Region: TOBE; cl01440 229193015435 TOBE domain; Region: TOBE_2; pfam08402 229193015436 BlastProDom match to entry PD039360 sp_O27709_O27709_METTH, E-value 5e-08 229193015437 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 229193015438 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193015439 Walker A/P-loop; other site 229193015440 ATP binding site [chemical binding]; other site 229193015441 Q-loop/lid; other site 229193015442 ABC transporter signature motif; other site 229193015443 Walker B; other site 229193015444 D-loop; other site 229193015445 H-loop/switch region; other site 229193015446 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193015447 probable transmembrane helix predicted by TMHMM2.0 229193015448 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193015449 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193015450 TM-ABC transporter signature motif; other site 229193015451 probable transmembrane helix predicted by TMHMM2.0 229193015452 probable transmembrane helix predicted by TMHMM2.0 229193015453 probable transmembrane helix predicted by TMHMM2.0 229193015454 probable transmembrane helix predicted by TMHMM2.0 229193015455 probable transmembrane helix predicted by TMHMM2.0 229193015456 probable transmembrane helix predicted by TMHMM2.0 229193015457 probable transmembrane helix predicted by TMHMM2.0 229193015458 probable transmembrane helix predicted by TMHMM2.0 229193015459 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 229193015460 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 229193015461 putative ligand binding site [chemical binding]; other site 229193015462 probable transmembrane helix predicted by TMHMM2.0 229193015463 probable transmembrane helix predicted by TMHMM2.0 229193015464 hypothetical protein; Provisional; Region: PRK11479 229193015465 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 229193015466 Predicted transcriptional regulators [Transcription]; Region: COG1695 229193015467 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 229193015468 BlastProDom match to entry PD005604 sp_Q9A275_Q9A275_CAUCR, E-value 2e-19 229193015469 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 229193015470 PAAR motif; Region: PAAR_motif; pfam05488 229193015471 probable transmembrane helix predicted by TMHMM2.0 229193015472 probable transmembrane helix predicted by TMHMM2.0 229193015473 probable transmembrane helix predicted by TMHMM2.0 229193015474 probable transmembrane helix predicted by TMHMM2.0 229193015475 probable transmembrane helix predicted by TMHMM2.0 229193015476 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 229193015477 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 229193015478 PAAR motif; Region: PAAR_motif; pfam05488 229193015479 Pyocin large subunit [General function prediction only]; Region: COG5529 229193015480 S-type Pyocin; Region: Pyocin_S; pfam06958 229193015481 Fic family protein [Function unknown]; Region: COG3177 229193015482 Fic/DOC family; Region: Fic; pfam02661 229193015483 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 229193015484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 229193015485 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 229193015486 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 229193015487 D5 N terminal like; Region: D5_N; smart00885 229193015488 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 229193015489 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 229193015490 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 229193015491 toxin interface [polypeptide binding]; other site 229193015492 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 229193015493 Zn binding site [ion binding]; other site 229193015494 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 229193015495 non-specific DNA binding site [nucleotide binding]; other site 229193015496 salt bridge; other site 229193015497 sequence-specific DNA binding site [nucleotide binding]; other site 229193015498 BlastProDom match to entry PD081545 sp_Q46864_YGIT_ECOLI, E-value 8e-44 229193015499 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 229193015500 peptide binding site [polypeptide binding]; other site 229193015501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 229193015502 non-specific DNA binding site [nucleotide binding]; other site 229193015503 salt bridge; other site 229193015504 sequence-specific DNA binding site [nucleotide binding]; other site 229193015505 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 229193015506 integrase; Provisional; Region: PRK09692 229193015507 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 229193015508 active site 229193015509 Int/Topo IB signature motif; other site 229193015510 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 229193015511 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 229193015512 dimer interface [polypeptide binding]; other site 229193015513 putative anticodon binding site; other site 229193015514 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 229193015515 motif 1; other site 229193015516 active site 229193015517 motif 2; other site 229193015518 motif 3; other site 229193015519 peptide chain release factor 2; Provisional; Region: PRK08787 229193015520 This domain is found in peptide chain release factors; Region: PCRF; smart00937 229193015521 RF-1 domain; Region: RF-1; pfam00472 229193015522 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 229193015523 DHH family; Region: DHH; pfam01368 229193015524 DHHA1 domain; Region: DHHA1; pfam02272 229193015525 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 229193015526 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 229193015527 dimerization domain [polypeptide binding]; other site 229193015528 dimer interface [polypeptide binding]; other site 229193015529 catalytic residues [active] 229193015530 BlastProDom match to entry PD013570 sp_P39691_DSBC_ERWCH, E-value 2e-94 229193015531 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 229193015532 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 229193015533 active site 229193015534 Int/Topo IB signature motif; other site 229193015535 flavodoxin FldB; Provisional; Region: PRK12359 229193015536 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 229193015537 ProfileScan match to entry PS50319 LEU_RICH, E-value 11.338 229193015538 probable transmembrane helix predicted by TMHMM2.0 229193015539 probable transmembrane helix predicted by TMHMM2.0 229193015540 probable transmembrane helix predicted by TMHMM2.0 229193015541 probable transmembrane helix predicted by TMHMM2.0 229193015542 probable transmembrane helix predicted by TMHMM2.0 229193015543 probable transmembrane helix predicted by TMHMM2.0 229193015544 sensory histidine kinase CreC; Provisional; Region: PRK11100 229193015545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193015546 dimer interface [polypeptide binding]; other site 229193015547 phosphorylation site [posttranslational modification] 229193015548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193015549 ATP binding site [chemical binding]; other site 229193015550 Mg2+ binding site [ion binding]; other site 229193015551 G-X-G motif; other site 229193015552 probable transmembrane helix predicted by TMHMM2.0 229193015553 probable transmembrane helix predicted by TMHMM2.0 229193015554 DNA-binding response regulator CreB; Provisional; Region: PRK11083 229193015555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193015556 active site 229193015557 phosphorylation site [posttranslational modification] 229193015558 intermolecular recognition site; other site 229193015559 dimerization interface [polypeptide binding]; other site 229193015560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193015561 DNA binding site [nucleotide binding] 229193015562 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 229193015563 probable transmembrane helix predicted by TMHMM2.0 229193015564 hypothetical protein; Provisional; Region: PRK10878 229193015565 putative global regulator; Reviewed; Region: PRK09559 229193015566 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 229193015567 Predicted small integral membrane protein [Function unknown]; Region: COG5472 229193015568 probable transmembrane helix predicted by TMHMM2.0 229193015569 probable transmembrane helix predicted by TMHMM2.0 229193015570 probable transmembrane helix predicted by TMHMM2.0 229193015571 probable transmembrane helix predicted by TMHMM2.0 229193015572 hemolysin; Provisional; Region: PRK15087 229193015573 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 229193015574 probable transmembrane helix predicted by TMHMM2.0 229193015575 probable transmembrane helix predicted by TMHMM2.0 229193015576 probable transmembrane helix predicted by TMHMM2.0 229193015577 probable transmembrane helix predicted by TMHMM2.0 229193015578 probable transmembrane helix predicted by TMHMM2.0 229193015579 probable transmembrane helix predicted by TMHMM2.0 229193015580 probable transmembrane helix predicted by TMHMM2.0 229193015581 probable transmembrane helix predicted by TMHMM2.0 229193015582 ProfileScan match to entry PS50310 ALA_RICH, E-value 9.528 229193015583 probable transmembrane helix predicted by TMHMM2.0 229193015584 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 229193015585 glycine dehydrogenase; Provisional; Region: PRK05367 229193015586 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 229193015587 tetramer interface [polypeptide binding]; other site 229193015588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193015589 catalytic residue [active] 229193015590 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 229193015591 tetramer interface [polypeptide binding]; other site 229193015592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193015593 catalytic residue [active] 229193015594 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 229193015595 lipoyl attachment site [posttranslational modification]; other site 229193015596 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 229193015597 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 229193015598 oxidoreductase; Provisional; Region: PRK08013 229193015599 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 229193015600 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 229193015601 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 229193015602 proline aminopeptidase P II; Provisional; Region: PRK10879 229193015603 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 229193015604 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 229193015605 active site 229193015606 HMMPfam match to entry PF05195 AMP_N, E-value 1.9e-59 229193015607 hypothetical protein; Reviewed; Region: PRK01736 229193015608 Z-ring-associated protein; Provisional; Region: PRK10972 229193015609 HMMPfam match to entry PF05164 DUF710, E-value 5.4e-30 229193015610 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 229193015611 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 229193015612 BlastProDom match to entry PD004590 sp_Q9CKA4_Q9CKA4_PASMU, E-value 6e-52 229193015613 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 229193015614 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 229193015615 ligand binding site [chemical binding]; other site 229193015616 NAD binding site [chemical binding]; other site 229193015617 tetramer interface [polypeptide binding]; other site 229193015618 catalytic site [active] 229193015619 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 229193015620 L-serine binding site [chemical binding]; other site 229193015621 ACT domain interface; other site 229193015622 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 229193015623 tetramer (dimer of dimers) interface [polypeptide binding]; other site 229193015624 active site 229193015625 dimer interface [polypeptide binding]; other site 229193015626 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 229193015627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193015628 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 229193015629 putative dimerization interface [polypeptide binding]; other site 229193015630 Uncharacterized conserved protein [Function unknown]; Region: COG2968 229193015631 oxidative stress defense protein; Provisional; Region: PRK11087 229193015632 HMMPfam match to entry PF04402 DUF541, E-value 4.3e-71 229193015633 probable transmembrane helix predicted by TMHMM2.0 229193015634 probable transmembrane helix predicted by TMHMM2.0 229193015635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193015636 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193015637 DNA-binding interface [nucleotide binding]; DNA binding site 229193015638 Integrase core domain; Region: rve; pfam00665 229193015639 transposase/IS protein; Provisional; Region: PRK09183 229193015640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193015641 Walker A motif; other site 229193015642 ATP binding site [chemical binding]; other site 229193015643 Walker B motif; other site 229193015644 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 229193015645 active site 229193015646 8-oxo-dGMP binding site [chemical binding]; other site 229193015647 nudix motif; other site 229193015648 metal binding site [ion binding]; metal-binding site 229193015649 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 229193015650 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 229193015651 SEC-C motif; Region: SEC-C; pfam02810 229193015652 SecA regulator SecM; Provisional; Region: PRK02943 229193015653 probable transmembrane helix predicted by TMHMM2.0 229193015654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 229193015655 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 229193015656 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 229193015657 cell division protein FtsZ; Validated; Region: PRK09330 229193015658 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 229193015659 nucleotide binding site [chemical binding]; other site 229193015660 SulA interaction site; other site 229193015661 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 229193015662 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 229193015663 Cell division protein FtsA; Region: FtsA; pfam14450 229193015664 cell division protein FtsQ; Provisional; Region: PRK10775 229193015665 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 229193015666 Cell division protein FtsQ; Region: FtsQ; pfam03799 229193015667 probable transmembrane helix predicted by TMHMM2.0 229193015668 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 229193015669 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 229193015670 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 229193015671 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 229193015672 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 229193015673 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 229193015674 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 229193015675 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 229193015676 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 229193015677 active site 229193015678 homodimer interface [polypeptide binding]; other site 229193015679 HMMPfam match to entry PF04101 Glyco_tran_28_C, E-value 1.2e-48 229193015680 cell division protein FtsW; Provisional; Region: PRK10774 229193015681 probable transmembrane helix predicted by TMHMM2.0 229193015682 probable transmembrane helix predicted by TMHMM2.0 229193015683 probable transmembrane helix predicted by TMHMM2.0 229193015684 probable transmembrane helix predicted by TMHMM2.0 229193015685 probable transmembrane helix predicted by TMHMM2.0 229193015686 probable transmembrane helix predicted by TMHMM2.0 229193015687 probable transmembrane helix predicted by TMHMM2.0 229193015688 probable transmembrane helix predicted by TMHMM2.0 229193015689 probable transmembrane helix predicted by TMHMM2.0 229193015690 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 229193015691 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 229193015692 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 229193015693 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 229193015694 probable transmembrane helix predicted by TMHMM2.0 229193015695 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 229193015696 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 229193015697 Mg++ binding site [ion binding]; other site 229193015698 putative catalytic motif [active] 229193015699 putative substrate binding site [chemical binding]; other site 229193015700 probable transmembrane helix predicted by TMHMM2.0 229193015701 probable transmembrane helix predicted by TMHMM2.0 229193015702 probable transmembrane helix predicted by TMHMM2.0 229193015703 probable transmembrane helix predicted by TMHMM2.0 229193015704 probable transmembrane helix predicted by TMHMM2.0 229193015705 probable transmembrane helix predicted by TMHMM2.0 229193015706 probable transmembrane helix predicted by TMHMM2.0 229193015707 probable transmembrane helix predicted by TMHMM2.0 229193015708 probable transmembrane helix predicted by TMHMM2.0 229193015709 probable transmembrane helix predicted by TMHMM2.0 229193015710 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 229193015711 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 229193015712 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 229193015713 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 229193015714 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 229193015715 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 229193015716 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 229193015717 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 229193015718 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 229193015719 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 229193015720 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 229193015721 probable transmembrane helix predicted by TMHMM2.0 229193015722 cell division protein FtsL; Provisional; Region: PRK10772 229193015723 probable transmembrane helix predicted by TMHMM2.0 229193015724 MraW methylase family; Region: Methyltransf_5; pfam01795 229193015725 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 229193015726 cell division protein MraZ; Reviewed; Region: PRK00326 229193015727 MraZ protein; Region: MraZ; pfam02381 229193015728 MraZ protein; Region: MraZ; pfam02381 229193015729 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 229193015730 probable transmembrane helix predicted by TMHMM2.0 229193015731 probable transmembrane helix predicted by TMHMM2.0 229193015732 probable transmembrane helix predicted by TMHMM2.0 229193015733 probable transmembrane helix predicted by TMHMM2.0 229193015734 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 229193015735 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193015736 DNA binding site [nucleotide binding] 229193015737 domain linker motif; other site 229193015738 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 229193015739 dimerization interface [polypeptide binding]; other site 229193015740 ligand binding site [chemical binding]; other site 229193015741 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193015742 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 229193015743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193015744 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 229193015745 putative substrate binding pocket [chemical binding]; other site 229193015746 putative dimerization interface [polypeptide binding]; other site 229193015747 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 229193015748 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 229193015749 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 229193015750 acyl-activating enzyme (AAE) consensus motif; other site 229193015751 acyl-activating enzyme (AAE) consensus motif; other site 229193015752 putative AMP binding site [chemical binding]; other site 229193015753 putative active site [active] 229193015754 putative CoA binding site [chemical binding]; other site 229193015755 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 229193015756 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 229193015757 PYR/PP interface [polypeptide binding]; other site 229193015758 dimer interface [polypeptide binding]; other site 229193015759 TPP binding site [chemical binding]; other site 229193015760 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 229193015761 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 229193015762 TPP-binding site [chemical binding]; other site 229193015763 dimer interface [polypeptide binding]; other site 229193015764 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 229193015765 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 229193015766 putative valine binding site [chemical binding]; other site 229193015767 dimer interface [polypeptide binding]; other site 229193015768 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 229193015769 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193015770 2-isopropylmalate synthase; Validated; Region: PRK00915 229193015771 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 229193015772 active site 229193015773 catalytic residues [active] 229193015774 metal binding site [ion binding]; metal-binding site 229193015775 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 229193015776 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 229193015777 tartrate dehydrogenase; Region: TTC; TIGR02089 229193015778 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 229193015779 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 229193015780 substrate binding site [chemical binding]; other site 229193015781 ligand binding site [chemical binding]; other site 229193015782 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 229193015783 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 229193015784 substrate binding site [chemical binding]; other site 229193015785 sugar efflux transporter; Region: 2A0120; TIGR00899 229193015786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193015787 putative substrate translocation pore; other site 229193015788 probable transmembrane helix predicted by TMHMM2.0 229193015789 probable transmembrane helix predicted by TMHMM2.0 229193015790 probable transmembrane helix predicted by TMHMM2.0 229193015791 probable transmembrane helix predicted by TMHMM2.0 229193015792 probable transmembrane helix predicted by TMHMM2.0 229193015793 probable transmembrane helix predicted by TMHMM2.0 229193015794 probable transmembrane helix predicted by TMHMM2.0 229193015795 probable transmembrane helix predicted by TMHMM2.0 229193015796 probable transmembrane helix predicted by TMHMM2.0 229193015797 probable transmembrane helix predicted by TMHMM2.0 229193015798 probable transmembrane helix predicted by TMHMM2.0 229193015799 probable transmembrane helix predicted by TMHMM2.0 229193015800 transcriptional regulator SgrR; Provisional; Region: PRK13626 229193015801 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 229193015802 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 229193015803 probable transmembrane helix predicted by TMHMM2.0 229193015804 probable transmembrane helix predicted by TMHMM2.0 229193015805 probable transmembrane helix predicted by TMHMM2.0 229193015806 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 229193015807 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 229193015808 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 229193015809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193015810 dimer interface [polypeptide binding]; other site 229193015811 conserved gate region; other site 229193015812 putative PBP binding loops; other site 229193015813 ABC-ATPase subunit interface; other site 229193015814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193015815 dimer interface [polypeptide binding]; other site 229193015816 conserved gate region; other site 229193015817 putative PBP binding loops; other site 229193015818 ABC-ATPase subunit interface; other site 229193015819 probable transmembrane helix predicted by TMHMM2.0 229193015820 probable transmembrane helix predicted by TMHMM2.0 229193015821 probable transmembrane helix predicted by TMHMM2.0 229193015822 probable transmembrane helix predicted by TMHMM2.0 229193015823 probable transmembrane helix predicted by TMHMM2.0 229193015824 probable transmembrane helix predicted by TMHMM2.0 229193015825 probable transmembrane helix predicted by TMHMM2.0 229193015826 probable transmembrane helix predicted by TMHMM2.0 229193015827 probable transmembrane helix predicted by TMHMM2.0 229193015828 probable transmembrane helix predicted by TMHMM2.0 229193015829 probable transmembrane helix predicted by TMHMM2.0 229193015830 probable transmembrane helix predicted by TMHMM2.0 229193015831 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 229193015832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193015833 Walker A/P-loop; other site 229193015834 ATP binding site [chemical binding]; other site 229193015835 Q-loop/lid; other site 229193015836 ABC transporter signature motif; other site 229193015837 Walker B; other site 229193015838 D-loop; other site 229193015839 H-loop/switch region; other site 229193015840 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 229193015841 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 229193015842 probable transmembrane helix predicted by TMHMM2.0 229193015843 probable transmembrane helix predicted by TMHMM2.0 229193015844 probable transmembrane helix predicted by TMHMM2.0 229193015845 probable transmembrane helix predicted by TMHMM2.0 229193015846 probable transmembrane helix predicted by TMHMM2.0 229193015847 probable transmembrane helix predicted by TMHMM2.0 229193015848 DNA polymerase II; Reviewed; Region: PRK05762 229193015849 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 229193015850 active site 229193015851 catalytic site [active] 229193015852 substrate binding site [chemical binding]; other site 229193015853 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 229193015854 active site 229193015855 metal-binding site 229193015856 ATP-dependent helicase HepA; Validated; Region: PRK04914 229193015857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 229193015858 ATP binding site [chemical binding]; other site 229193015859 putative Mg++ binding site [ion binding]; other site 229193015860 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193015861 nucleotide binding region [chemical binding]; other site 229193015862 ATP-binding site [chemical binding]; other site 229193015863 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 229193015864 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 229193015865 G1 box; other site 229193015866 GTP/Mg2+ binding site [chemical binding]; other site 229193015867 G2 box; other site 229193015868 G3 box; other site 229193015869 Switch II region; other site 229193015870 G4 box; other site 229193015871 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 229193015872 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 229193015873 probable transmembrane helix predicted by TMHMM2.0 229193015874 probable transmembrane helix predicted by TMHMM2.0 229193015875 probable transmembrane helix predicted by TMHMM2.0 229193015876 hypothetical protein; Provisional; Region: PRK07034 229193015877 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 229193015878 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 229193015879 ligand binding site [chemical binding]; other site 229193015880 probable transmembrane helix predicted by TMHMM2.0 229193015881 ProfileScan match to entry PS50321 ASN_RICH, E-value 12.902 229193015882 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 229193015883 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 229193015884 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 229193015885 probable transmembrane helix predicted by TMHMM2.0 229193015886 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 229193015887 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 229193015888 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 229193015889 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 229193015890 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 229193015891 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 229193015892 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 229193015893 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 229193015894 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 229193015895 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 229193015896 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 229193015897 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 229193015898 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 229193015899 ProfileScan match to entry PS50324 SER_RICH, E-value 28.622 229193015900 ProfileScan match to entry PS50325 THR_RICH, E-value 18.831 229193015901 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 229193015902 Clp amino terminal domain; Region: Clp_N; pfam02861 229193015903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193015904 Walker A motif; other site 229193015905 ATP binding site [chemical binding]; other site 229193015906 Walker B motif; other site 229193015907 arginine finger; other site 229193015908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193015909 Walker A motif; other site 229193015910 ATP binding site [chemical binding]; other site 229193015911 Walker B motif; other site 229193015912 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 229193015913 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 229193015914 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 229193015915 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 229193015916 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 229193015917 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 229193015918 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 229193015919 Protein of unknown function (DUF877); Region: DUF877; pfam05943 229193015920 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 229193015921 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 229193015922 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 229193015923 Uncharacterized conserved protein [Function unknown]; Region: COG5419 229193015924 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 229193015925 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 229193015926 active site 229193015927 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 229193015928 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 229193015929 putative metal binding site [ion binding]; other site 229193015930 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 229193015931 HSP70 interaction site [polypeptide binding]; other site 229193015932 probable transmembrane helix predicted by TMHMM2.0 229193015933 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 229193015934 OstA-like protein; Region: OstA; pfam03968 229193015935 Organic solvent tolerance protein; Region: OstA_C; pfam04453 229193015936 HMMPfam match to entry PF04453 OstA_C, E-value 2.7e-131 229193015937 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 229193015938 SurA N-terminal domain; Region: SurA_N; pfam09312 229193015939 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 229193015940 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 229193015941 BlastProDom match to entry PD002510 sp_P21202_SURA_ECOLI, E-value 5e-36 229193015942 BlastProDom match to entry PD002510 sp_P21202_SURA_ECOLI, E-value 4e-30 229193015943 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 229193015944 HMMPfam match to entry PF04166 PdxA, E-value 4.9e-167 229193015945 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 229193015946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193015947 S-adenosylmethionine binding site [chemical binding]; other site 229193015948 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 229193015949 HMMPfam match to entry PF04379 DUF525, E-value 2.3e-57 229193015950 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 229193015951 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 229193015952 active site 229193015953 metal binding site [ion binding]; metal-binding site 229193015954 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 229193015955 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 229193015956 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 229193015957 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 229193015958 folate binding site [chemical binding]; other site 229193015959 NADP+ binding site [chemical binding]; other site 229193015960 hypothetical protein; Provisional; Region: PRK09917 229193015961 probable transmembrane helix predicted by TMHMM2.0 229193015962 probable transmembrane helix predicted by TMHMM2.0 229193015963 probable transmembrane helix predicted by TMHMM2.0 229193015964 probable transmembrane helix predicted by TMHMM2.0 229193015965 Uncharacterized conserved protein [Function unknown]; Region: COG2966 229193015966 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 229193015967 probable transmembrane helix predicted by TMHMM2.0 229193015968 probable transmembrane helix predicted by TMHMM2.0 229193015969 probable transmembrane helix predicted by TMHMM2.0 229193015970 probable transmembrane helix predicted by TMHMM2.0 229193015971 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 229193015972 probable transmembrane helix predicted by TMHMM2.0 229193015973 probable transmembrane helix predicted by TMHMM2.0 229193015974 probable transmembrane helix predicted by TMHMM2.0 229193015975 probable transmembrane helix predicted by TMHMM2.0 229193015976 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 229193015977 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 229193015978 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 229193015979 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 229193015980 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 229193015981 ATP-grasp domain; Region: ATP-grasp_4; cl17255 229193015982 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 229193015983 IMP binding site; other site 229193015984 dimer interface [polypeptide binding]; other site 229193015985 interdomain contacts; other site 229193015986 partial ornithine binding site; other site 229193015987 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 229193015988 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 229193015989 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 229193015990 catalytic site [active] 229193015991 subunit interface [polypeptide binding]; other site 229193015992 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 229193015993 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 229193015994 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 229193015995 HMMPfam match to entry PF05173 DapB_C, E-value 1.1e-77 229193015996 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193015997 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 229193015998 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 229193015999 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 229193016000 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 229193016001 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 229193016002 lipoprotein signal peptidase; Provisional; Region: PRK14787 229193016003 probable transmembrane helix predicted by TMHMM2.0 229193016004 probable transmembrane helix predicted by TMHMM2.0 229193016005 probable transmembrane helix predicted by TMHMM2.0 229193016006 probable transmembrane helix predicted by TMHMM2.0 229193016007 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 229193016008 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 229193016009 active site 229193016010 HIGH motif; other site 229193016011 nucleotide binding site [chemical binding]; other site 229193016012 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 229193016013 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 229193016014 active site 229193016015 KMSKS motif; other site 229193016016 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 229193016017 tRNA binding surface [nucleotide binding]; other site 229193016018 anticodon binding site; other site 229193016019 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 229193016020 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 229193016021 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 229193016022 active site 229193016023 Riboflavin kinase; Region: Flavokinase; smart00904 229193016024 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 229193016025 HMMTigr match to entry TIGR00029 S20, E-value 1.5e-42 229193016026 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 229193016027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193016028 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 229193016029 putative dimerization interface [polypeptide binding]; other site 229193016030 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 229193016031 probable transmembrane helix predicted by TMHMM2.0 229193016032 probable transmembrane helix predicted by TMHMM2.0 229193016033 probable transmembrane helix predicted by TMHMM2.0 229193016034 probable transmembrane helix predicted by TMHMM2.0 229193016035 probable transmembrane helix predicted by TMHMM2.0 229193016036 probable transmembrane helix predicted by TMHMM2.0 229193016037 probable transmembrane helix predicted by TMHMM2.0 229193016038 probable transmembrane helix predicted by TMHMM2.0 229193016039 probable transmembrane helix predicted by TMHMM2.0 229193016040 probable transmembrane helix predicted by TMHMM2.0 229193016041 chaperone protein DnaJ; Provisional; Region: PRK10767 229193016042 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 229193016043 HSP70 interaction site [polypeptide binding]; other site 229193016044 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 229193016045 substrate binding site [polypeptide binding]; other site 229193016046 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 229193016047 Zn binding sites [ion binding]; other site 229193016048 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 229193016049 dimer interface [polypeptide binding]; other site 229193016050 ProfileScan match to entry PS50315 GLY_RICH, E-value 10.553 229193016051 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 229193016052 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 229193016053 nucleotide binding site [chemical binding]; other site 229193016054 hypothetical protein; Provisional; Region: PRK10659 229193016055 probable transmembrane helix predicted by TMHMM2.0 229193016056 probable transmembrane helix predicted by TMHMM2.0 229193016057 probable transmembrane helix predicted by TMHMM2.0 229193016058 probable transmembrane helix predicted by TMHMM2.0 229193016059 probable transmembrane helix predicted by TMHMM2.0 229193016060 probable transmembrane helix predicted by TMHMM2.0 229193016061 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 229193016062 metabolite-proton symporter; Region: 2A0106; TIGR00883 229193016063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193016064 putative substrate translocation pore; other site 229193016065 probable transmembrane helix predicted by TMHMM2.0 229193016066 probable transmembrane helix predicted by TMHMM2.0 229193016067 probable transmembrane helix predicted by TMHMM2.0 229193016068 probable transmembrane helix predicted by TMHMM2.0 229193016069 probable transmembrane helix predicted by TMHMM2.0 229193016070 probable transmembrane helix predicted by TMHMM2.0 229193016071 probable transmembrane helix predicted by TMHMM2.0 229193016072 probable transmembrane helix predicted by TMHMM2.0 229193016073 probable transmembrane helix predicted by TMHMM2.0 229193016074 probable transmembrane helix predicted by TMHMM2.0 229193016075 probable transmembrane helix predicted by TMHMM2.0 229193016076 probable transmembrane helix predicted by TMHMM2.0 229193016077 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 229193016078 MPT binding site; other site 229193016079 trimer interface [polypeptide binding]; other site 229193016080 transaldolase-like protein; Provisional; Region: PTZ00411 229193016081 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 229193016082 active site 229193016083 dimer interface [polypeptide binding]; other site 229193016084 catalytic residue [active] 229193016085 hypothetical protein; Validated; Region: PRK02101 229193016086 threonine synthase; Validated; Region: PRK09225 229193016087 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 229193016088 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193016089 catalytic residue [active] 229193016090 homoserine kinase; Provisional; Region: PRK01212 229193016091 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 229193016092 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 229193016093 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 229193016094 putative catalytic residues [active] 229193016095 putative nucleotide binding site [chemical binding]; other site 229193016096 putative aspartate binding site [chemical binding]; other site 229193016097 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 229193016098 dimer interface [polypeptide binding]; other site 229193016099 putative threonine allosteric regulatory site; other site 229193016100 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 229193016101 putative threonine allosteric regulatory site; other site 229193016102 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 229193016103 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 229193016104 probable transmembrane helix predicted by TMHMM2.0 229193016105 two-component response regulator; Provisional; Region: PRK11173 229193016106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193016107 active site 229193016108 phosphorylation site [posttranslational modification] 229193016109 intermolecular recognition site; other site 229193016110 dimerization interface [polypeptide binding]; other site 229193016111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 229193016112 DNA binding site [nucleotide binding] 229193016113 hypothetical protein; Provisional; Region: PRK10756 229193016114 CreA protein; Region: CreA; pfam05981 229193016115 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 229193016116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193016117 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 229193016118 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 229193016119 catalytic core [active] 229193016120 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 229193016121 Trp operon repressor; Provisional; Region: PRK01381 229193016122 lytic murein transglycosylase; Provisional; Region: PRK11619 229193016123 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 229193016124 N-acetyl-D-glucosamine binding site [chemical binding]; other site 229193016125 catalytic residue [active] 229193016126 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 229193016127 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 229193016128 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 229193016129 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 229193016130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193016131 motif II; other site 229193016132 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 229193016133 probable transmembrane helix predicted by TMHMM2.0 229193016134 probable transmembrane helix predicted by TMHMM2.0 229193016135 probable transmembrane helix predicted by TMHMM2.0 229193016136 probable transmembrane helix predicted by TMHMM2.0 229193016137 probable transmembrane helix predicted by TMHMM2.0 229193016138 probable transmembrane helix predicted by TMHMM2.0 229193016139 probable transmembrane helix predicted by TMHMM2.0 229193016140 probable transmembrane helix predicted by TMHMM2.0 229193016141 probable transmembrane helix predicted by TMHMM2.0 229193016142 probable transmembrane helix predicted by TMHMM2.0 229193016143 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 229193016144 probable transmembrane helix predicted by TMHMM2.0 229193016145 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 229193016146 HAMP domain; Region: HAMP; pfam00672 229193016147 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 229193016148 metal binding site [ion binding]; metal-binding site 229193016149 active site 229193016150 I-site; other site 229193016151 probable transmembrane helix predicted by TMHMM2.0 229193016152 probable transmembrane helix predicted by TMHMM2.0 229193016153 putative outer membrane lipoprotein; Provisional; Region: PRK09967 229193016154 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 229193016155 ligand binding site [chemical binding]; other site 229193016156 probable transmembrane helix predicted by TMHMM2.0 229193016157 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 229193016158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193016159 Walker A/P-loop; other site 229193016160 ATP binding site [chemical binding]; other site 229193016161 Q-loop/lid; other site 229193016162 ABC transporter signature motif; other site 229193016163 Walker B; other site 229193016164 D-loop; other site 229193016165 H-loop/switch region; other site 229193016166 ABC transporter; Region: ABC_tran_2; pfam12848 229193016167 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 229193016168 Fic family protein [Function unknown]; Region: COG3177 229193016169 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 229193016170 Fic/DOC family; Region: Fic; pfam02661 229193016171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 229193016172 non-specific DNA binding site [nucleotide binding]; other site 229193016173 salt bridge; other site 229193016174 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 229193016175 sequence-specific DNA binding site [nucleotide binding]; other site 229193016176 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 229193016177 active site 229193016178 nucleotide binding site [chemical binding]; other site 229193016179 HIGH motif; other site 229193016180 KMSKS motif; other site 229193016181 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 229193016182 DNA repair protein RadA; Provisional; Region: PRK11823 229193016183 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 229193016184 Walker A motif/ATP binding site; other site 229193016185 ATP binding site [chemical binding]; other site 229193016186 Walker B motif; other site 229193016187 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 229193016188 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 229193016189 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193016190 motif II; other site 229193016191 hypothetical protein; Provisional; Region: PRK11246 229193016192 probable transmembrane helix predicted by TMHMM2.0 229193016193 probable transmembrane helix predicted by TMHMM2.0 229193016194 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 229193016195 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 229193016196 phosphopentomutase; Provisional; Region: PRK05362 229193016197 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 229193016198 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 229193016199 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 229193016200 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 229193016201 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 229193016202 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 229193016203 intersubunit interface [polypeptide binding]; other site 229193016204 active site 229193016205 catalytic residue [active] 229193016206 HMMTigr match to entry TIGR00126 deoC, E-value 2.8e-86 229193016207 BlastProDom match to entry PD005801 sp_P00882_DEOC_ECOLI, E-value 2e-67 229193016208 HMMTigr match to entry TIGR00126 deoC, E-value 5.3e-83 229193016209 BlastProDom match to entry PD005801 sp_P44430_DEOC_HAEIN, E-value 9e-64 229193016210 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 229193016211 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 229193016212 Nucleoside recognition; Region: Gate; pfam07670 229193016213 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 229193016214 probable transmembrane helix predicted by TMHMM2.0 229193016215 probable transmembrane helix predicted by TMHMM2.0 229193016216 probable transmembrane helix predicted by TMHMM2.0 229193016217 probable transmembrane helix predicted by TMHMM2.0 229193016218 probable transmembrane helix predicted by TMHMM2.0 229193016219 probable transmembrane helix predicted by TMHMM2.0 229193016220 probable transmembrane helix predicted by TMHMM2.0 229193016221 probable transmembrane helix predicted by TMHMM2.0 229193016222 probable transmembrane helix predicted by TMHMM2.0 229193016223 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 229193016224 active site 229193016225 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 229193016226 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 229193016227 active site 229193016228 nucleophile elbow; other site 229193016229 probable transmembrane helix predicted by TMHMM2.0 229193016230 probable transmembrane helix predicted by TMHMM2.0 229193016231 periplasmic protein; Provisional; Region: PRK10568 229193016232 BON domain; Region: BON; pfam04972 229193016233 BON domain; Region: BON; pfam04972 229193016234 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 229193016235 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 229193016236 G1 box; other site 229193016237 putative GEF interaction site [polypeptide binding]; other site 229193016238 GTP/Mg2+ binding site [chemical binding]; other site 229193016239 Switch I region; other site 229193016240 G2 box; other site 229193016241 G3 box; other site 229193016242 Switch II region; other site 229193016243 G4 box; other site 229193016244 G5 box; other site 229193016245 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 229193016246 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 229193016247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 229193016248 Coenzyme A binding pocket [chemical binding]; other site 229193016249 DNA polymerase III subunit psi; Validated; Region: PRK06856 229193016250 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 229193016251 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 229193016252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193016253 S-adenosylmethionine binding site [chemical binding]; other site 229193016254 HMMPfam match to entry PF05175 MTS, E-value 6e-11 229193016255 HMMPfam match to entry PF05175 MTS, E-value 2.3e-17 229193016256 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 229193016257 probable transmembrane helix predicted by TMHMM2.0 229193016258 probable transmembrane helix predicted by TMHMM2.0 229193016259 probable transmembrane helix predicted by TMHMM2.0 229193016260 probable transmembrane helix predicted by TMHMM2.0 229193016261 probable transmembrane helix predicted by TMHMM2.0 229193016262 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 229193016263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 229193016264 metal binding site [ion binding]; metal-binding site 229193016265 active site 229193016266 I-site; other site 229193016267 probable transmembrane helix predicted by TMHMM2.0 229193016268 probable transmembrane helix predicted by TMHMM2.0 229193016269 probable transmembrane helix predicted by TMHMM2.0 229193016270 probable transmembrane helix predicted by TMHMM2.0 229193016271 probable transmembrane helix predicted by TMHMM2.0 229193016272 Pectinesterase; Region: Pectinesterase; pfam01095 229193016273 putative pectinesterase; Region: PLN02432; cl01911 229193016274 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 229193016275 probable transmembrane helix predicted by TMHMM2.0 229193016276 probable transmembrane helix predicted by TMHMM2.0 229193016277 probable transmembrane helix predicted by TMHMM2.0 229193016278 probable transmembrane helix predicted by TMHMM2.0 229193016279 probable transmembrane helix predicted by TMHMM2.0 229193016280 probable transmembrane helix predicted by TMHMM2.0 229193016281 probable transmembrane helix predicted by TMHMM2.0 229193016282 probable transmembrane helix predicted by TMHMM2.0 229193016283 probable transmembrane helix predicted by TMHMM2.0 229193016284 probable transmembrane helix predicted by TMHMM2.0 229193016285 probable transmembrane helix predicted by TMHMM2.0 229193016286 probable transmembrane helix predicted by TMHMM2.0 229193016287 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 229193016288 Peptidase family M23; Region: Peptidase_M23; pfam01551 229193016289 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193016290 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 229193016291 probable transmembrane helix predicted by TMHMM2.0 229193016292 probable transmembrane helix predicted by TMHMM2.0 229193016293 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 229193016294 O-Antigen ligase; Region: Wzy_C; pfam04932 229193016295 probable transmembrane helix predicted by TMHMM2.0 229193016296 probable transmembrane helix predicted by TMHMM2.0 229193016297 probable transmembrane helix predicted by TMHMM2.0 229193016298 probable transmembrane helix predicted by TMHMM2.0 229193016299 probable transmembrane helix predicted by TMHMM2.0 229193016300 probable transmembrane helix predicted by TMHMM2.0 229193016301 probable transmembrane helix predicted by TMHMM2.0 229193016302 probable transmembrane helix predicted by TMHMM2.0 229193016303 probable transmembrane helix predicted by TMHMM2.0 229193016304 probable transmembrane helix predicted by TMHMM2.0 229193016305 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 229193016306 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 229193016307 putative active site [active] 229193016308 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 229193016309 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 229193016310 putative N- and C-terminal domain interface [polypeptide binding]; other site 229193016311 putative active site [active] 229193016312 putative MgATP binding site [chemical binding]; other site 229193016313 catalytic site [active] 229193016314 metal binding site [ion binding]; metal-binding site 229193016315 putative carbohydrate binding site [chemical binding]; other site 229193016316 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 229193016317 transcriptional regulator LsrR; Provisional; Region: PRK15418 229193016318 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 229193016319 non-specific DNA interactions [nucleotide binding]; other site 229193016320 DNA binding site [nucleotide binding] 229193016321 sequence specific DNA binding site [nucleotide binding]; other site 229193016322 putative cAMP binding site [chemical binding]; other site 229193016323 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 229193016324 HMMPfam match to entry PF04198 Sugar-bind, E-value 1.5e-86 229193016325 probable transmembrane helix predicted by TMHMM2.0 229193016326 probable transmembrane helix predicted by TMHMM2.0 229193016327 probable transmembrane helix predicted by TMHMM2.0 229193016328 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 229193016329 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193016330 Walker A/P-loop; other site 229193016331 ATP binding site [chemical binding]; other site 229193016332 Q-loop/lid; other site 229193016333 ABC transporter signature motif; other site 229193016334 Walker B; other site 229193016335 D-loop; other site 229193016336 H-loop/switch region; other site 229193016337 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193016338 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193016339 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193016340 TM-ABC transporter signature motif; other site 229193016341 probable transmembrane helix predicted by TMHMM2.0 229193016342 probable transmembrane helix predicted by TMHMM2.0 229193016343 probable transmembrane helix predicted by TMHMM2.0 229193016344 probable transmembrane helix predicted by TMHMM2.0 229193016345 probable transmembrane helix predicted by TMHMM2.0 229193016346 probable transmembrane helix predicted by TMHMM2.0 229193016347 probable transmembrane helix predicted by TMHMM2.0 229193016348 probable transmembrane helix predicted by TMHMM2.0 229193016349 probable transmembrane helix predicted by TMHMM2.0 229193016350 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193016351 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193016352 TM-ABC transporter signature motif; other site 229193016353 probable transmembrane helix predicted by TMHMM2.0 229193016354 probable transmembrane helix predicted by TMHMM2.0 229193016355 probable transmembrane helix predicted by TMHMM2.0 229193016356 probable transmembrane helix predicted by TMHMM2.0 229193016357 probable transmembrane helix predicted by TMHMM2.0 229193016358 probable transmembrane helix predicted by TMHMM2.0 229193016359 probable transmembrane helix predicted by TMHMM2.0 229193016360 probable transmembrane helix predicted by TMHMM2.0 229193016361 probable transmembrane helix predicted by TMHMM2.0 229193016362 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 229193016363 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 229193016364 ligand binding site [chemical binding]; other site 229193016365 probable transmembrane helix predicted by TMHMM2.0 229193016366 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 229193016367 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 229193016368 putative active site; other site 229193016369 catalytic residue [active] 229193016370 BlastProDom match to entry PD008351 sp_P76143_YNEB_ECOLI, E-value e-123 229193016371 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 229193016372 hypothetical protein; Provisional; Region: PRK11667 229193016373 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 229193016374 dimerization domain swap beta strand [polypeptide binding]; other site 229193016375 regulatory protein interface [polypeptide binding]; other site 229193016376 active site 229193016377 regulatory phosphorylation site [posttranslational modification]; other site 229193016378 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 229193016379 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 229193016380 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 229193016381 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 229193016382 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 229193016383 active site 229193016384 phosphorylation site [posttranslational modification] 229193016385 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 229193016386 probable transmembrane helix predicted by TMHMM2.0 229193016387 probable transmembrane helix predicted by TMHMM2.0 229193016388 probable transmembrane helix predicted by TMHMM2.0 229193016389 probable transmembrane helix predicted by TMHMM2.0 229193016390 probable transmembrane helix predicted by TMHMM2.0 229193016391 probable transmembrane helix predicted by TMHMM2.0 229193016392 probable transmembrane helix predicted by TMHMM2.0 229193016393 probable transmembrane helix predicted by TMHMM2.0 229193016394 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 229193016395 active site 229193016396 P-loop; other site 229193016397 phosphorylation site [posttranslational modification] 229193016398 probable transmembrane helix predicted by TMHMM2.0 229193016399 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 229193016400 active site 229193016401 P-loop; other site 229193016402 phosphorylation site [posttranslational modification] 229193016403 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 229193016404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193016405 Predicted membrane protein [Function unknown]; Region: COG4269 229193016406 probable transmembrane helix predicted by TMHMM2.0 229193016407 probable transmembrane helix predicted by TMHMM2.0 229193016408 probable transmembrane helix predicted by TMHMM2.0 229193016409 probable transmembrane helix predicted by TMHMM2.0 229193016410 probable transmembrane helix predicted by TMHMM2.0 229193016411 probable transmembrane helix predicted by TMHMM2.0 229193016412 probable transmembrane helix predicted by TMHMM2.0 229193016413 probable transmembrane helix predicted by TMHMM2.0 229193016414 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 229193016415 probable transmembrane helix predicted by TMHMM2.0 229193016416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 229193016417 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 229193016418 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 229193016419 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 229193016420 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 229193016421 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 229193016422 ATP binding site [chemical binding]; other site 229193016423 Mg2+ binding site [ion binding]; other site 229193016424 G-X-G motif; other site 229193016425 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 229193016426 Methyltransferase domain; Region: Methyltransf_26; pfam13659 229193016427 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 229193016428 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 229193016429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 229193016430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 229193016431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193016432 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193016433 DNA-binding interface [nucleotide binding]; DNA binding site 229193016434 Integrase core domain; Region: rve; pfam00665 229193016435 transposase/IS protein; Provisional; Region: PRK09183 229193016436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193016437 Walker A motif; other site 229193016438 ATP binding site [chemical binding]; other site 229193016439 Walker B motif; other site 229193016440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193016441 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 229193016442 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 229193016443 dimerization interface [polypeptide binding]; other site 229193016444 Pirin-related protein [General function prediction only]; Region: COG1741 229193016445 Pirin; Region: Pirin; pfam02678 229193016446 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 229193016447 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 229193016448 putative SAM binding site [chemical binding]; other site 229193016449 putative homodimer interface [polypeptide binding]; other site 229193016450 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 229193016451 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 229193016452 putative ligand binding site [chemical binding]; other site 229193016453 HMMPfam match to entry PF04348 LppC, E-value 2e-148 229193016454 hypothetical protein; Reviewed; Region: PRK12497 229193016455 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 229193016456 dimer interface [polypeptide binding]; other site 229193016457 active site 229193016458 outer membrane lipoprotein; Provisional; Region: PRK11023 229193016459 BON domain; Region: BON; pfam04972 229193016460 BON domain; Region: BON; cl02771 229193016461 probable transmembrane helix predicted by TMHMM2.0 229193016462 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 229193016463 Transglycosylase; Region: Transgly; cl17702 229193016464 probable transmembrane helix predicted by TMHMM2.0 229193016465 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 229193016466 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 229193016467 conserved cys residue [active] 229193016468 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 229193016469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 229193016470 putative active site [active] 229193016471 heme pocket [chemical binding]; other site 229193016472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 229193016473 dimer interface [polypeptide binding]; other site 229193016474 phosphorylation site [posttranslational modification] 229193016475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193016476 ATP binding site [chemical binding]; other site 229193016477 Mg2+ binding site [ion binding]; other site 229193016478 G-X-G motif; other site 229193016479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 229193016480 active site 229193016481 phosphorylation site [posttranslational modification] 229193016482 intermolecular recognition site; other site 229193016483 dimerization interface [polypeptide binding]; other site 229193016484 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 229193016485 putative binding surface; other site 229193016486 active site 229193016487 probable transmembrane helix predicted by TMHMM2.0 229193016488 probable transmembrane helix predicted by TMHMM2.0 229193016489 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 229193016490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 229193016491 FeS/SAM binding site; other site 229193016492 HMMPfam match to entry PF04055 Radical_SAM, E-value 9.3e-14 229193016493 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 229193016494 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 229193016495 active site 229193016496 dimer interface [polypeptide binding]; other site 229193016497 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 229193016498 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 229193016499 active site 229193016500 FMN binding site [chemical binding]; other site 229193016501 substrate binding site [chemical binding]; other site 229193016502 3Fe-4S cluster binding site [ion binding]; other site 229193016503 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 229193016504 domain interface; other site 229193016505 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 229193016506 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 229193016507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 229193016508 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 229193016509 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 229193016510 HMMPfam match to entry PF04386 SspB, E-value 1.2e-87 229193016511 stringent starvation protein A; Provisional; Region: sspA; PRK09481 229193016512 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 229193016513 C-terminal domain interface [polypeptide binding]; other site 229193016514 putative GSH binding site (G-site) [chemical binding]; other site 229193016515 dimer interface [polypeptide binding]; other site 229193016516 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 229193016517 dimer interface [polypeptide binding]; other site 229193016518 N-terminal domain interface [polypeptide binding]; other site 229193016519 BlastProDom match to entry PD085547 sp_Q26950_Q26950_TRYCR, E-value 5e-07 229193016520 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 229193016521 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 229193016522 23S rRNA interface [nucleotide binding]; other site 229193016523 L3 interface [polypeptide binding]; other site 229193016524 Predicted ATPase [General function prediction only]; Region: COG1485 229193016525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 229193016526 hypothetical protein; Provisional; Region: PRK11677 229193016527 probable transmembrane helix predicted by TMHMM2.0 229193016528 serine endoprotease; Provisional; Region: PRK10139 229193016529 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 229193016530 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 229193016531 protein binding site [polypeptide binding]; other site 229193016532 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 229193016533 probable transmembrane helix predicted by TMHMM2.0 229193016534 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193016535 serine endoprotease; Provisional; Region: PRK10898 229193016536 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 229193016537 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 229193016538 protein binding site [polypeptide binding]; other site 229193016539 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 229193016540 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 229193016541 hinge; other site 229193016542 active site 229193016543 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 229193016544 BlastProDom match to entry PD004789 sp_Q9RHA0_Q9RHA0_SHIFL, E-value 2e-28 229193016545 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 229193016546 anti sigma factor interaction site; other site 229193016547 regulatory phosphorylation site [posttranslational modification]; other site 229193016548 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 229193016549 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 229193016550 mce related protein; Region: MCE; pfam02470 229193016551 probable transmembrane helix predicted by TMHMM2.0 229193016552 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 229193016553 conserved hypothetical integral membrane protein; Region: TIGR00056 229193016554 probable transmembrane helix predicted by TMHMM2.0 229193016555 probable transmembrane helix predicted by TMHMM2.0 229193016556 probable transmembrane helix predicted by TMHMM2.0 229193016557 probable transmembrane helix predicted by TMHMM2.0 229193016558 probable transmembrane helix predicted by TMHMM2.0 229193016559 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 229193016560 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 229193016561 Walker A/P-loop; other site 229193016562 ATP binding site [chemical binding]; other site 229193016563 Q-loop/lid; other site 229193016564 ABC transporter signature motif; other site 229193016565 Walker B; other site 229193016566 D-loop; other site 229193016567 H-loop/switch region; other site 229193016568 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 229193016569 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 229193016570 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 229193016571 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 229193016572 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 229193016573 putative active site [active] 229193016574 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 229193016575 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 229193016576 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 229193016577 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 229193016578 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 229193016579 probable transmembrane helix predicted by TMHMM2.0 229193016580 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 229193016581 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 229193016582 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 229193016583 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 229193016584 Walker A/P-loop; other site 229193016585 ATP binding site [chemical binding]; other site 229193016586 Q-loop/lid; other site 229193016587 ABC transporter signature motif; other site 229193016588 Walker B; other site 229193016589 D-loop; other site 229193016590 H-loop/switch region; other site 229193016591 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 229193016592 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 229193016593 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 229193016594 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 229193016595 HMMPfam match to entry PF04552 sigma54_DBD, E-value 3.1e-104 229193016596 Contains Sigma 54 modulation protein/ribosomal protein S30EA (Interpro|IPR003489) . Contains Sigma 54 modulation protein/ribosomal protein S30EA (Interpro|IPR003489) 229193016597 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 229193016598 active site 229193016599 phosphorylation site [posttranslational modification] 229193016600 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 229193016601 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 229193016602 dimerization domain swap beta strand [polypeptide binding]; other site 229193016603 regulatory protein interface [polypeptide binding]; other site 229193016604 active site 229193016605 regulatory phosphorylation site [posttranslational modification]; other site 229193016606 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 229193016607 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 229193016608 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 229193016609 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 229193016610 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 229193016611 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 229193016612 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 229193016613 homotrimer interaction site [polypeptide binding]; other site 229193016614 putative active site [active] 229193016615 BlastProDom match to entry PD002429 sp_Q9X445_Q9X445_SALTY, E-value 3e-41 229193016616 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 229193016617 dimer interface [polypeptide binding]; other site 229193016618 putative inhibitory loop; other site 229193016619 trehalose repressor; Provisional; Region: treR; PRK09492 229193016620 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 229193016621 DNA binding site [nucleotide binding] 229193016622 domain linker motif; other site 229193016623 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 229193016624 dimerization interface [polypeptide binding]; other site 229193016625 ligand binding site [chemical binding]; other site 229193016626 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 229193016627 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 229193016628 active site turn [active] 229193016629 phosphorylation site [posttranslational modification] 229193016630 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 229193016631 probable transmembrane helix predicted by TMHMM2.0 229193016632 probable transmembrane helix predicted by TMHMM2.0 229193016633 probable transmembrane helix predicted by TMHMM2.0 229193016634 probable transmembrane helix predicted by TMHMM2.0 229193016635 probable transmembrane helix predicted by TMHMM2.0 229193016636 probable transmembrane helix predicted by TMHMM2.0 229193016637 probable transmembrane helix predicted by TMHMM2.0 229193016638 probable transmembrane helix predicted by TMHMM2.0 229193016639 probable transmembrane helix predicted by TMHMM2.0 229193016640 probable transmembrane helix predicted by TMHMM2.0 229193016641 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 229193016642 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 229193016643 Ca binding site [ion binding]; other site 229193016644 active site 229193016645 catalytic site [active] 229193016646 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 229193016647 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 229193016648 Soluble cytochrome b562 [Energy production and conversion]; Region: CybC; COG3783 229193016649 peptidase PmbA; Provisional; Region: PRK11040 229193016650 hypothetical protein; Provisional; Region: PRK05255 229193016651 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 229193016652 RNAase interaction site [polypeptide binding]; other site 229193016653 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 229193016654 active site 229193016655 probable transmembrane helix predicted by TMHMM2.0 229193016656 Contains Aldehyde dehydrogenase (Interpro|IPR002086, (GO:0008152), (GO:0016491)) . Contains Aldehyde dehydrogenase (Interpro|IPR002086, (GO:0008152), (GO:0016491)). Contains ATP/GTP-binding site motif A (P-loop) (Interpro|IPR001687, (GO:0005524)). Contains Aldehyde dehydrogenase (Interpro|IPR002086, (GO:0008152), (GO:0016491)) 229193016657 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 229193016658 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 229193016659 probable transmembrane helix predicted by TMHMM2.0 229193016660 probable transmembrane helix predicted by TMHMM2.0 229193016661 probable transmembrane helix predicted by TMHMM2.0 229193016662 probable transmembrane helix predicted by TMHMM2.0 229193016663 probable transmembrane helix predicted by TMHMM2.0 229193016664 probable transmembrane helix predicted by TMHMM2.0 229193016665 probable transmembrane helix predicted by TMHMM2.0 229193016666 probable transmembrane helix predicted by TMHMM2.0 229193016667 probable transmembrane helix predicted by TMHMM2.0 229193016668 probable transmembrane helix predicted by TMHMM2.0 229193016669 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 229193016670 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 229193016671 HlyD family secretion protein; Region: HlyD_3; pfam13437 229193016672 probable transmembrane helix predicted by TMHMM2.0 229193016673 efflux system membrane protein; Provisional; Region: PRK11594 229193016674 probable transmembrane helix predicted by TMHMM2.0 229193016675 probable transmembrane helix predicted by TMHMM2.0 229193016676 transcriptional regulator; Provisional; Region: PRK10632 229193016677 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 229193016678 putative effector binding pocket; other site 229193016679 dimerization interface [polypeptide binding]; other site 229193016680 Transcriptional regulator [Transcription]; Region: LysR; COG0583 229193016681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 229193016682 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 229193016683 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 229193016684 Family description; Region: VCBS; pfam13517 229193016685 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 229193016686 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 229193016687 probable transmembrane helix predicted by TMHMM2.0 229193016688 probable transmembrane helix predicted by TMHMM2.0 229193016689 probable transmembrane helix predicted by TMHMM2.0 229193016690 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 229193016691 probable transmembrane helix predicted by TMHMM2.0 229193016692 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 229193016693 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 229193016694 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 229193016695 active site 229193016696 catalytic residues [active] 229193016697 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 229193016698 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 229193016699 ProfileScan match to entry PS50324 SER_RICH, E-value 10.292 229193016700 protease TldD; Provisional; Region: tldD; PRK10735 229193016701 nitrilase; Region: PLN02798 229193016702 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 229193016703 putative active site [active] 229193016704 catalytic triad [active] 229193016705 dimer interface [polypeptide binding]; other site 229193016706 hypothetical protein; Provisional; Region: PRK10899 229193016707 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 229193016708 probable transmembrane helix predicted by TMHMM2.0 229193016709 ribonuclease G; Provisional; Region: PRK11712 229193016710 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 229193016711 homodimer interface [polypeptide binding]; other site 229193016712 oligonucleotide binding site [chemical binding]; other site 229193016713 Maf-like protein; Region: Maf; pfam02545 229193016714 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 229193016715 active site 229193016716 dimer interface [polypeptide binding]; other site 229193016717 rod shape-determining protein MreD; Provisional; Region: PRK11060 229193016718 HMMPfam match to entry PF04093 MreD, E-value 4.8e-54 229193016719 probable transmembrane helix predicted by TMHMM2.0 229193016720 probable transmembrane helix predicted by TMHMM2.0 229193016721 probable transmembrane helix predicted by TMHMM2.0 229193016722 probable transmembrane helix predicted by TMHMM2.0 229193016723 probable transmembrane helix predicted by TMHMM2.0 229193016724 rod shape-determining protein MreC; Region: mreC; TIGR00219 229193016725 rod shape-determining protein MreC; Region: MreC; pfam04085 229193016726 HMMPfam match to entry PF04085 MreC, E-value 8e-67 229193016727 probable transmembrane helix predicted by TMHMM2.0 229193016728 rod shape-determining protein MreB; Provisional; Region: PRK13927 229193016729 MreB and similar proteins; Region: MreB_like; cd10225 229193016730 nucleotide binding site [chemical binding]; other site 229193016731 Mg binding site [ion binding]; other site 229193016732 putative protofilament interaction site [polypeptide binding]; other site 229193016733 RodZ interaction site [polypeptide binding]; other site 229193016734 regulatory protein CsrD; Provisional; Region: PRK11059 229193016735 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 229193016736 metal binding site [ion binding]; metal-binding site 229193016737 active site 229193016738 I-site; other site 229193016739 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 229193016740 probable transmembrane helix predicted by TMHMM2.0 229193016741 probable transmembrane helix predicted by TMHMM2.0 229193016742 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 229193016743 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 229193016744 NADP binding site [chemical binding]; other site 229193016745 dimer interface [polypeptide binding]; other site 229193016746 TMAO/DMSO reductase; Reviewed; Region: PRK05363 229193016747 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 229193016748 Moco binding site; other site 229193016749 metal coordination site [ion binding]; other site 229193016750 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 229193016751 ProfileScan match to entry PS50319 LEU_RICH, E-value 10.910 229193016752 probable transmembrane helix predicted by TMHMM2.0 229193016753 probable transmembrane helix predicted by TMHMM2.0 229193016754 probable transmembrane helix predicted by TMHMM2.0 229193016755 probable transmembrane helix predicted by TMHMM2.0 229193016756 probable transmembrane helix predicted by TMHMM2.0 229193016757 probable transmembrane helix predicted by TMHMM2.0 229193016758 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 229193016759 Dehydroquinase class II; Region: DHquinase_II; pfam01220 229193016760 active site 229193016761 trimer interface [polypeptide binding]; other site 229193016762 dimer interface [polypeptide binding]; other site 229193016763 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 229193016764 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 229193016765 carboxyltransferase (CT) interaction site; other site 229193016766 biotinylation site [posttranslational modification]; other site 229193016767 ProfileScan match to entry PS50310 ALA_RICH, E-value 8.657 229193016768 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 229193016769 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 229193016770 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 229193016771 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 229193016772 hypothetical protein; Provisional; Region: PRK10633 229193016773 probable transmembrane helix predicted by TMHMM2.0 229193016774 probable transmembrane helix predicted by TMHMM2.0 229193016775 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 229193016776 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 229193016777 Na binding site [ion binding]; other site 229193016778 probable transmembrane helix predicted by TMHMM2.0 229193016779 probable transmembrane helix predicted by TMHMM2.0 229193016780 probable transmembrane helix predicted by TMHMM2.0 229193016781 probable transmembrane helix predicted by TMHMM2.0 229193016782 probable transmembrane helix predicted by TMHMM2.0 229193016783 probable transmembrane helix predicted by TMHMM2.0 229193016784 probable transmembrane helix predicted by TMHMM2.0 229193016785 probable transmembrane helix predicted by TMHMM2.0 229193016786 probable transmembrane helix predicted by TMHMM2.0 229193016787 probable transmembrane helix predicted by TMHMM2.0 229193016788 probable transmembrane helix predicted by TMHMM2.0 229193016789 probable transmembrane helix predicted by TMHMM2.0 229193016790 probable transmembrane helix predicted by TMHMM2.0 229193016791 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 229193016792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 229193016793 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 229193016794 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 229193016795 FMN binding site [chemical binding]; other site 229193016796 active site 229193016797 catalytic residues [active] 229193016798 substrate binding site [chemical binding]; other site 229193016799 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 229193016800 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 229193016801 ProfileScan match to entry PS50116 HTH_FIS_FAMILY, E-value 16.173 229193016802 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 229193016803 Transcriptional regulators [Transcription]; Region: GntR; COG1802 229193016804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 229193016805 DNA-binding site [nucleotide binding]; DNA binding site 229193016806 FCD domain; Region: FCD; pfam07729 229193016807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193016808 metabolite-proton symporter; Region: 2A0106; TIGR00883 229193016809 putative substrate translocation pore; other site 229193016810 probable transmembrane helix predicted by TMHMM2.0 229193016811 probable transmembrane helix predicted by TMHMM2.0 229193016812 probable transmembrane helix predicted by TMHMM2.0 229193016813 probable transmembrane helix predicted by TMHMM2.0 229193016814 probable transmembrane helix predicted by TMHMM2.0 229193016815 probable transmembrane helix predicted by TMHMM2.0 229193016816 probable transmembrane helix predicted by TMHMM2.0 229193016817 probable transmembrane helix predicted by TMHMM2.0 229193016818 probable transmembrane helix predicted by TMHMM2.0 229193016819 probable transmembrane helix predicted by TMHMM2.0 229193016820 probable transmembrane helix predicted by TMHMM2.0 229193016821 probable transmembrane helix predicted by TMHMM2.0 229193016822 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 229193016823 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 229193016824 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 229193016825 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 229193016826 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 229193016827 ProfileScan match to entry PS50315 GLY_RICH, E-value 9.319 229193016828 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 229193016829 DNA-binding site [nucleotide binding]; DNA binding site 229193016830 RNA-binding motif; other site 229193016831 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 229193016832 DNA-binding site [nucleotide binding]; DNA binding site 229193016833 RNA-binding motif; other site 229193016834 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193016835 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 229193016836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 229193016837 putative S-transferase; Provisional; Region: PRK11752 229193016838 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 229193016839 C-terminal domain interface [polypeptide binding]; other site 229193016840 GSH binding site (G-site) [chemical binding]; other site 229193016841 dimer interface [polypeptide binding]; other site 229193016842 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 229193016843 dimer interface [polypeptide binding]; other site 229193016844 N-terminal domain interface [polypeptide binding]; other site 229193016845 active site 229193016846 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 229193016847 putative active site [active] 229193016848 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 229193016849 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 229193016850 N- and C-terminal domain interface [polypeptide binding]; other site 229193016851 active site 229193016852 MgATP binding site [chemical binding]; other site 229193016853 catalytic site [active] 229193016854 metal binding site [ion binding]; metal-binding site 229193016855 carbohydrate binding site [chemical binding]; other site 229193016856 putative homodimer interface [polypeptide binding]; other site 229193016857 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193016858 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193016859 TM-ABC transporter signature motif; other site 229193016860 probable transmembrane helix predicted by TMHMM2.0 229193016861 probable transmembrane helix predicted by TMHMM2.0 229193016862 probable transmembrane helix predicted by TMHMM2.0 229193016863 probable transmembrane helix predicted by TMHMM2.0 229193016864 probable transmembrane helix predicted by TMHMM2.0 229193016865 probable transmembrane helix predicted by TMHMM2.0 229193016866 probable transmembrane helix predicted by TMHMM2.0 229193016867 probable transmembrane helix predicted by TMHMM2.0 229193016868 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 229193016869 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 229193016870 TM-ABC transporter signature motif; other site 229193016871 probable transmembrane helix predicted by TMHMM2.0 229193016872 probable transmembrane helix predicted by TMHMM2.0 229193016873 probable transmembrane helix predicted by TMHMM2.0 229193016874 probable transmembrane helix predicted by TMHMM2.0 229193016875 probable transmembrane helix predicted by TMHMM2.0 229193016876 probable transmembrane helix predicted by TMHMM2.0 229193016877 probable transmembrane helix predicted by TMHMM2.0 229193016878 probable transmembrane helix predicted by TMHMM2.0 229193016879 probable transmembrane helix predicted by TMHMM2.0 229193016880 probable transmembrane helix predicted by TMHMM2.0 229193016881 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 229193016882 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 229193016883 Walker A/P-loop; other site 229193016884 ATP binding site [chemical binding]; other site 229193016885 Q-loop/lid; other site 229193016886 ABC transporter signature motif; other site 229193016887 Walker B; other site 229193016888 D-loop; other site 229193016889 H-loop/switch region; other site 229193016890 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 229193016891 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 229193016892 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 229193016893 ligand binding site [chemical binding]; other site 229193016894 probable transmembrane helix predicted by TMHMM2.0 229193016895 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 229193016896 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 229193016897 putative acyl-acceptor binding pocket; other site 229193016898 probable transmembrane helix predicted by TMHMM2.0 229193016899 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 229193016900 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 229193016901 probable transmembrane helix predicted by TMHMM2.0 229193016902 probable transmembrane helix predicted by TMHMM2.0 229193016903 probable transmembrane helix predicted by TMHMM2.0 229193016904 probable transmembrane helix predicted by TMHMM2.0 229193016905 probable transmembrane helix predicted by TMHMM2.0 229193016906 probable transmembrane helix predicted by TMHMM2.0 229193016907 probable transmembrane helix predicted by TMHMM2.0 229193016908 probable transmembrane helix predicted by TMHMM2.0 229193016909 probable transmembrane helix predicted by TMHMM2.0 229193016910 probable transmembrane helix predicted by TMHMM2.0 229193016911 probable transmembrane helix predicted by TMHMM2.0 229193016912 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 229193016913 probable transmembrane helix predicted by TMHMM2.0 229193016914 probable transmembrane helix predicted by TMHMM2.0 229193016915 probable transmembrane helix predicted by TMHMM2.0 229193016916 BlastProDom match to entry PD005952 sp_P32702_YJCD_ECOLI, E-value 1e-45 229193016917 probable transmembrane helix predicted by TMHMM2.0 229193016918 probable transmembrane helix predicted by TMHMM2.0 229193016919 probable transmembrane helix predicted by TMHMM2.0 229193016920 probable transmembrane helix predicted by TMHMM2.0 229193016921 probable transmembrane helix predicted by TMHMM2.0 229193016922 BlastProDom match to entry PD005770 sp_P32702_YJCD_ECOLI, E-value 1e-71 229193016923 probable transmembrane helix predicted by TMHMM2.0 229193016924 probable transmembrane helix predicted by TMHMM2.0 229193016925 probable transmembrane helix predicted by TMHMM2.0 229193016926 probable transmembrane helix predicted by TMHMM2.0 229193016927 probable transmembrane helix predicted by TMHMM2.0 229193016928 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 229193016929 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 229193016930 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 229193016931 Walker A/P-loop; other site 229193016932 ATP binding site [chemical binding]; other site 229193016933 Q-loop/lid; other site 229193016934 ABC transporter signature motif; other site 229193016935 Walker B; other site 229193016936 D-loop; other site 229193016937 H-loop/switch region; other site 229193016938 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 229193016939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193016940 dimer interface [polypeptide binding]; other site 229193016941 conserved gate region; other site 229193016942 putative PBP binding loops; other site 229193016943 ABC-ATPase subunit interface; other site 229193016944 probable transmembrane helix predicted by TMHMM2.0 229193016945 probable transmembrane helix predicted by TMHMM2.0 229193016946 probable transmembrane helix predicted by TMHMM2.0 229193016947 probable transmembrane helix predicted by TMHMM2.0 229193016948 probable transmembrane helix predicted by TMHMM2.0 229193016949 probable transmembrane helix predicted by TMHMM2.0 229193016950 probable transmembrane helix predicted by TMHMM2.0 229193016951 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 229193016952 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 229193016953 active site 229193016954 dimer interface [polypeptide binding]; other site 229193016955 non-prolyl cis peptide bond; other site 229193016956 insertion regions; other site 229193016957 probable transmembrane helix predicted by TMHMM2.0 229193016958 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 229193016959 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 229193016960 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 229193016961 intersubunit interface [polypeptide binding]; other site 229193016962 active site 229193016963 catalytic residue [active] 229193016964 HMMTigr match to entry TIGR00126 deoC, E-value 3.7e-45 229193016965 BlastProDom match to entry PD005801 sp_O26909_DEOC_METTH, E-value 1e-22 229193016966 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 229193016967 substrate binding site [chemical binding]; other site 229193016968 dimer interface [polypeptide binding]; other site 229193016969 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 229193016970 ATP binding site [chemical binding]; other site 229193016971 BlastProDom match to entry PD023180 sp_Q9X055_Q9X055_THEMA, E-value 2e-09 229193016972 ABC-type ribose transport system, auxiliary component [Carbohydrate transport and metabolism]; Region: RbsD; COG1869 229193016973 HMMPfam match to entry PF05025 RbsD_FucU, E-value 3.5e-18 229193016974 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 229193016975 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 229193016976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193016977 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 229193016978 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 229193016979 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 229193016980 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 229193016981 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 229193016982 AP (apurinic/apyrimidinic) site pocket; other site 229193016983 DNA interaction; other site 229193016984 Metal-binding active site; metal-binding site 229193016985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193016986 MULE transposase domain; Region: MULE; pfam10551 229193016987 PAAR motif; Region: PAAR_motif; pfam05488 229193016988 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 229193016989 RHS Repeat; Region: RHS_repeat; pfam05593 229193016990 RHS Repeat; Region: RHS_repeat; pfam05593 229193016991 RHS Repeat; Region: RHS_repeat; pfam05593 229193016992 RHS Repeat; Region: RHS_repeat; pfam05593 229193016993 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 229193016994 RHS protein; Region: RHS; pfam03527 229193016995 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 229193016996 probable transmembrane helix predicted by TMHMM2.0 229193016997 probable transmembrane helix predicted by TMHMM2.0 229193016998 probable transmembrane helix predicted by TMHMM2.0 229193016999 Uncharacterized conserved protein [Function unknown]; Region: COG5435 229193017000 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 229193017001 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 229193017002 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 229193017003 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 229193017004 ImpA domain protein; Region: DUF3702; pfam12486 229193017005 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 229193017006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 229193017007 non-specific DNA binding site [nucleotide binding]; other site 229193017008 salt bridge; other site 229193017009 sequence-specific DNA binding site [nucleotide binding]; other site 229193017010 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 229193017011 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 229193017012 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 229193017013 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 229193017014 RHS protein; Region: RHS; pfam03527 229193017015 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 229193017016 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 229193017017 PAAR motif; Region: PAAR_motif; pfam05488 229193017018 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 229193017019 RHS Repeat; Region: RHS_repeat; pfam05593 229193017020 RHS Repeat; Region: RHS_repeat; pfam05593 229193017021 RHS Repeat; Region: RHS_repeat; cl11982 229193017022 probable transmembrane helix predicted by TMHMM2.0 229193017023 probable transmembrane helix predicted by TMHMM2.0 229193017024 probable transmembrane helix predicted by TMHMM2.0 229193017025 Uncharacterized conserved protein [Function unknown]; Region: COG5435 229193017026 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 229193017027 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 229193017028 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 229193017029 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 229193017030 ImpA domain protein; Region: DUF3702; pfam12486 229193017031 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 229193017032 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 229193017033 probable transmembrane helix predicted by TMHMM2.0 229193017034 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 229193017035 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 229193017036 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 229193017037 probable transmembrane helix predicted by TMHMM2.0 229193017038 probable transmembrane helix predicted by TMHMM2.0 229193017039 probable transmembrane helix predicted by TMHMM2.0 229193017040 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 229193017041 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 229193017042 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 229193017043 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 229193017044 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 229193017045 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 229193017046 ProfileScan match to entry PS50116 HTH_FIS_FAMILY, E-value 9.008 229193017047 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 229193017048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193017049 Walker A motif; other site 229193017050 ATP binding site [chemical binding]; other site 229193017051 Walker B motif; other site 229193017052 arginine finger; other site 229193017053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193017054 Walker A motif; other site 229193017055 ATP binding site [chemical binding]; other site 229193017056 Walker B motif; other site 229193017057 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 229193017058 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 229193017059 probable transmembrane helix predicted by TMHMM2.0 229193017060 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 229193017061 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 229193017062 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 229193017063 probable transmembrane helix predicted by TMHMM2.0 229193017064 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 229193017065 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 229193017066 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 229193017067 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193017068 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193017069 putative transposase OrfB; Reviewed; Region: PHA02517 229193017070 HTH-like domain; Region: HTH_21; pfam13276 229193017071 Integrase core domain; Region: rve; pfam00665 229193017072 Integrase core domain; Region: rve_2; pfam13333 229193017073 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 229193017074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 229193017075 putative substrate translocation pore; other site 229193017076 probable transmembrane helix predicted by TMHMM2.0 229193017077 probable transmembrane helix predicted by TMHMM2.0 229193017078 probable transmembrane helix predicted by TMHMM2.0 229193017079 probable transmembrane helix predicted by TMHMM2.0 229193017080 probable transmembrane helix predicted by TMHMM2.0 229193017081 probable transmembrane helix predicted by TMHMM2.0 229193017082 probable transmembrane helix predicted by TMHMM2.0 229193017083 probable transmembrane helix predicted by TMHMM2.0 229193017084 probable transmembrane helix predicted by TMHMM2.0 229193017085 probable transmembrane helix predicted by TMHMM2.0 229193017086 probable transmembrane helix predicted by TMHMM2.0 229193017087 probable transmembrane helix predicted by TMHMM2.0 229193017088 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 229193017089 probable transmembrane helix predicted by TMHMM2.0 229193017090 probable transmembrane helix predicted by TMHMM2.0 229193017091 probable transmembrane helix predicted by TMHMM2.0 229193017092 probable transmembrane helix predicted by TMHMM2.0 229193017093 Contains Elongation factor Tu, domain 2 (Interpro|IPR004161, (GO:0005525)) . Contains Elongation factor Tu, domain 2 (Interpro|IPR004161, (GO:0005525)). Contains Translation elongation factor, selenocysteine-specific (Interpro|IPR004535, (GO:0001514), (GO:0005737)). Contains Elongation factor, GTP-binding (Interpro|IPR000795, (GO:0006414)). Contains ATP/GTP-binding site motif A (P-loop) (Interpro|IPR001687, (GO:0005524)) 229193017094 selenocysteine synthase; Provisional; Region: PRK04311 229193017095 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 229193017096 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 229193017097 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 229193017098 catalytic residue [active] 229193017099 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 229193017100 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 229193017101 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 229193017102 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 229193017103 probable transmembrane helix predicted by TMHMM2.0 229193017104 probable transmembrane helix predicted by TMHMM2.0 229193017105 probable transmembrane helix predicted by TMHMM2.0 229193017106 probable transmembrane helix predicted by TMHMM2.0 229193017107 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 229193017108 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 229193017109 Contains Formate dehydrogenase, alpha subunit, anaerobic (Interpro|IPR006443) . Contains Formate dehydrogenase, alpha subunit, anaerobic (Interpro|IPR006443). Contains Prokaryotic molybdopterin oxidoreductase (Interpro|IPR006655, (GO:0006118)). Contains Molybdopterin oxidoreductase (Interpro|IPR006656). Contains Molydopterin dinucleotide binding domain (Interpro|IPR006657). Contains Twin-arginine translocation pathway signal (Interpro|IPR006311). Contains Prokaryotic molybdopterin oxidoreductase (Interpro|IPR006655, (GO:0006118)). Contains Molybdopterin oxidoreductase Fe4S4 domain (Interpro|IPR006963) 229193017110 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 229193017111 superoxide dismutase; Provisional; Region: PRK10925 229193017112 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 229193017113 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 229193017114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 229193017115 dimerization interface [polypeptide binding]; other site 229193017116 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 229193017117 dimer interface [polypeptide binding]; other site 229193017118 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 229193017119 putative CheW interface [polypeptide binding]; other site 229193017120 probable transmembrane helix predicted by TMHMM2.0 229193017121 BlastProDom match to entry PD000571 sp_P05704_MCP3_ECOLI, E-value 4e-10 229193017122 probable transmembrane helix predicted by TMHMM2.0 229193017123 Electron transfer DM13; Region: DM13; pfam10517 229193017124 probable transmembrane helix predicted by TMHMM2.0 229193017125 hypothetical protein; Provisional; Region: PRK11020 229193017126 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 229193017127 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 229193017128 HMMPfam match to entry PF05068 MtlR, E-value 3e-90 229193017129 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 229193017130 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 229193017131 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 229193017132 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 229193017133 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 229193017134 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 229193017135 active site 229193017136 P-loop; other site 229193017137 phosphorylation site [posttranslational modification] 229193017138 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 229193017139 active site 229193017140 phosphorylation site [posttranslational modification] 229193017141 probable transmembrane helix predicted by TMHMM2.0 229193017142 probable transmembrane helix predicted by TMHMM2.0 229193017143 probable transmembrane helix predicted by TMHMM2.0 229193017144 probable transmembrane helix predicted by TMHMM2.0 229193017145 probable transmembrane helix predicted by TMHMM2.0 229193017146 probable transmembrane helix predicted by TMHMM2.0 229193017147 probable transmembrane helix predicted by TMHMM2.0 229193017148 probable transmembrane helix predicted by TMHMM2.0 229193017149 probable transmembrane helix predicted by TMHMM2.0 229193017150 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 229193017151 probable transmembrane helix predicted by TMHMM2.0 229193017152 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 229193017153 DALR anticodon binding domain; Region: DALR_1; pfam05746 229193017154 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 229193017155 dimer interface [polypeptide binding]; other site 229193017156 motif 1; other site 229193017157 active site 229193017158 motif 2; other site 229193017159 motif 3; other site 229193017160 BlastProDom match to entry PD006985 sp_P00960_SYGA_ECOLI, E-value e-158 229193017161 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 229193017162 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 229193017163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 229193017164 Coenzyme A binding pocket [chemical binding]; other site 229193017165 putative outer membrane lipoprotein; Provisional; Region: PRK10510 229193017166 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 229193017167 ligand binding site [chemical binding]; other site 229193017168 probable transmembrane helix predicted by TMHMM2.0 229193017169 probable transmembrane helix predicted by TMHMM2.0 229193017170 probable transmembrane helix predicted by TMHMM2.0 229193017171 Predicted transcriptional regulator [Transcription]; Region: COG2345 229193017172 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 229193017173 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 229193017174 dimerization interface [polypeptide binding]; other site 229193017175 ligand binding site [chemical binding]; other site 229193017176 NADP binding site [chemical binding]; other site 229193017177 catalytic site [active] 229193017178 alpha-amylase; Reviewed; Region: malS; PRK09505 229193017179 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 229193017180 active site 229193017181 catalytic site [active] 229193017182 probable transmembrane helix predicted by TMHMM2.0 229193017183 probable transmembrane helix predicted by TMHMM2.0 229193017184 probable transmembrane helix predicted by TMHMM2.0 229193017185 probable transmembrane helix predicted by TMHMM2.0 229193017186 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 229193017187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 229193017188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193017189 homodimer interface [polypeptide binding]; other site 229193017190 catalytic residue [active] 229193017191 putative transporter; Validated; Region: PRK03818 229193017192 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 229193017193 TrkA-C domain; Region: TrkA_C; pfam02080 229193017194 TrkA-C domain; Region: TrkA_C; pfam02080 229193017195 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 229193017196 probable transmembrane helix predicted by TMHMM2.0 229193017197 probable transmembrane helix predicted by TMHMM2.0 229193017198 probable transmembrane helix predicted by TMHMM2.0 229193017199 probable transmembrane helix predicted by TMHMM2.0 229193017200 probable transmembrane helix predicted by TMHMM2.0 229193017201 probable transmembrane helix predicted by TMHMM2.0 229193017202 probable transmembrane helix predicted by TMHMM2.0 229193017203 probable transmembrane helix predicted by TMHMM2.0 229193017204 probable transmembrane helix predicted by TMHMM2.0 229193017205 probable transmembrane helix predicted by TMHMM2.0 229193017206 probable transmembrane helix predicted by TMHMM2.0 229193017207 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 229193017208 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 229193017209 putative dimer interface [polypeptide binding]; other site 229193017210 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 229193017211 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 229193017212 putative dimer interface [polypeptide binding]; other site 229193017213 hypothetical protein; Provisional; Region: PRK11616 229193017214 hypothetical protein; Provisional; Region: PRK06815 229193017215 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 229193017216 tetramer interface [polypeptide binding]; other site 229193017217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 229193017218 catalytic residue [active] 229193017219 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 229193017220 ornithine cyclodeaminase; Validated; Region: PRK06823 229193017221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 229193017222 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193017223 Helix-turn-helix domain; Region: HTH_28; pfam13518 229193017224 putative transposase OrfB; Reviewed; Region: PHA02517 229193017225 HTH-like domain; Region: HTH_21; pfam13276 229193017226 Integrase core domain; Region: rve; pfam00665 229193017227 Integrase core domain; Region: rve_2; pfam13333 229193017228 sugar phosphate phosphatase; Provisional; Region: PRK10513 229193017229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193017230 active site 229193017231 motif I; other site 229193017232 motif II; other site 229193017233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193017234 probable transmembrane helix predicted by TMHMM2.0 229193017235 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 229193017236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 229193017237 Mg2+ binding site [ion binding]; other site 229193017238 G-X-G motif; other site 229193017239 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 229193017240 anchoring element; other site 229193017241 dimer interface [polypeptide binding]; other site 229193017242 ATP binding site [chemical binding]; other site 229193017243 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 229193017244 active site 229193017245 putative metal-binding site [ion binding]; other site 229193017246 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 229193017247 recombination protein F; Reviewed; Region: recF; PRK00064 229193017248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193017249 Walker A/P-loop; other site 229193017250 ATP binding site [chemical binding]; other site 229193017251 Q-loop/lid; other site 229193017252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193017253 ABC transporter signature motif; other site 229193017254 Walker B; other site 229193017255 D-loop; other site 229193017256 H-loop/switch region; other site 229193017257 DNA polymerase III subunit beta; Validated; Region: PRK05643 229193017258 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 229193017259 putative DNA binding surface [nucleotide binding]; other site 229193017260 dimer interface [polypeptide binding]; other site 229193017261 beta-clamp/clamp loader binding surface; other site 229193017262 beta-clamp/translesion DNA polymerase binding surface; other site 229193017263 DnaA N-terminal domain; Region: DnaA_N; pfam11638 229193017264 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 229193017265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193017266 Walker A motif; other site 229193017267 ATP binding site [chemical binding]; other site 229193017268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 229193017269 Walker B motif; other site 229193017270 arginine finger; other site 229193017271 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 229193017272 DnaA box-binding interface [nucleotide binding]; other site 229193017273 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 229193017274 ribonuclease P; Reviewed; Region: rnpA; PRK01732 229193017275 membrane protein insertase; Provisional; Region: PRK01318 229193017276 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 229193017277 probable transmembrane helix predicted by TMHMM2.0 229193017278 probable transmembrane helix predicted by TMHMM2.0 229193017279 probable transmembrane helix predicted by TMHMM2.0 229193017280 probable transmembrane helix predicted by TMHMM2.0 229193017281 probable transmembrane helix predicted by TMHMM2.0 229193017282 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 229193017283 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 229193017284 trmE is a tRNA modification GTPase; Region: trmE; cd04164 229193017285 G1 box; other site 229193017286 GTP/Mg2+ binding site [chemical binding]; other site 229193017287 Switch I region; other site 229193017288 G2 box; other site 229193017289 Switch II region; other site 229193017290 G3 box; other site 229193017291 G4 box; other site 229193017292 G5 box; other site 229193017293 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 229193017294 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 229193017295 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 229193017296 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 229193017297 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 229193017298 probable transmembrane helix predicted by TMHMM2.0 229193017299 probable transmembrane helix predicted by TMHMM2.0 229193017300 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 229193017301 probable transmembrane helix predicted by TMHMM2.0 229193017302 probable transmembrane helix predicted by TMHMM2.0 229193017303 probable transmembrane helix predicted by TMHMM2.0 229193017304 BlastProDom match to entry PD005952 sp_P31466_YIEG_ECOLI, E-value 7e-41 229193017305 probable transmembrane helix predicted by TMHMM2.0 229193017306 probable transmembrane helix predicted by TMHMM2.0 229193017307 probable transmembrane helix predicted by TMHMM2.0 229193017308 probable transmembrane helix predicted by TMHMM2.0 229193017309 probable transmembrane helix predicted by TMHMM2.0 229193017310 BlastProDom match to entry PD005770 sp_P31466_YIEG_ECOLI, E-value 7e-71 229193017311 probable transmembrane helix predicted by TMHMM2.0 229193017312 probable transmembrane helix predicted by TMHMM2.0 229193017313 probable transmembrane helix predicted by TMHMM2.0 229193017314 probable transmembrane helix predicted by TMHMM2.0 229193017315 probable transmembrane helix predicted by TMHMM2.0 229193017316 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 229193017317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 229193017318 motif II; other site 229193017319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193017320 dimer interface [polypeptide binding]; other site 229193017321 conserved gate region; other site 229193017322 putative PBP binding loops; other site 229193017323 ABC-ATPase subunit interface; other site 229193017324 probable transmembrane helix predicted by TMHMM2.0 229193017325 probable transmembrane helix predicted by TMHMM2.0 229193017326 probable transmembrane helix predicted by TMHMM2.0 229193017327 probable transmembrane helix predicted by TMHMM2.0 229193017328 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 229193017329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193017330 dimer interface [polypeptide binding]; other site 229193017331 conserved gate region; other site 229193017332 putative PBP binding loops; other site 229193017333 ABC-ATPase subunit interface; other site 229193017334 probable transmembrane helix predicted by TMHMM2.0 229193017335 probable transmembrane helix predicted by TMHMM2.0 229193017336 probable transmembrane helix predicted by TMHMM2.0 229193017337 probable transmembrane helix predicted by TMHMM2.0 229193017338 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 229193017339 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193017340 substrate binding pocket [chemical binding]; other site 229193017341 membrane-bound complex binding site; other site 229193017342 hinge residues; other site 229193017343 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 229193017344 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 229193017345 HMMPfam match to entry PF04519 DUF583, E-value 8.6e-27 229193017346 probable transmembrane helix predicted by TMHMM2.0 229193017347 probable transmembrane helix predicted by TMHMM2.0 229193017348 transcriptional regulator PhoU; Provisional; Region: PRK11115 229193017349 PhoU domain; Region: PhoU; pfam01895 229193017350 PhoU domain; Region: PhoU; pfam01895 229193017351 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 229193017352 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 229193017353 Walker A/P-loop; other site 229193017354 ATP binding site [chemical binding]; other site 229193017355 Q-loop/lid; other site 229193017356 ABC transporter signature motif; other site 229193017357 Walker B; other site 229193017358 D-loop; other site 229193017359 H-loop/switch region; other site 229193017360 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 229193017361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193017362 dimer interface [polypeptide binding]; other site 229193017363 conserved gate region; other site 229193017364 putative PBP binding loops; other site 229193017365 ABC-ATPase subunit interface; other site 229193017366 probable transmembrane helix predicted by TMHMM2.0 229193017367 probable transmembrane helix predicted by TMHMM2.0 229193017368 probable transmembrane helix predicted by TMHMM2.0 229193017369 probable transmembrane helix predicted by TMHMM2.0 229193017370 probable transmembrane helix predicted by TMHMM2.0 229193017371 probable transmembrane helix predicted by TMHMM2.0 229193017372 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 229193017373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 229193017374 dimer interface [polypeptide binding]; other site 229193017375 conserved gate region; other site 229193017376 putative PBP binding loops; other site 229193017377 ABC-ATPase subunit interface; other site 229193017378 probable transmembrane helix predicted by TMHMM2.0 229193017379 probable transmembrane helix predicted by TMHMM2.0 229193017380 probable transmembrane helix predicted by TMHMM2.0 229193017381 probable transmembrane helix predicted by TMHMM2.0 229193017382 probable transmembrane helix predicted by TMHMM2.0 229193017383 probable transmembrane helix predicted by TMHMM2.0 229193017384 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 229193017385 substrate binding pocket [chemical binding]; other site 229193017386 membrane-bound complex binding site; other site 229193017387 hinge residues; other site 229193017388 BlastProDom match to entry PD002295 sp_Q9Z9M3_Q9Z9M3_PSEAE, E-value 4e-77 229193017389 BlastProDom match to entry PD002295 sp_O32484_O32484_ENTCL, E-value e-112 229193017390 probable transmembrane helix predicted by TMHMM2.0 229193017391 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 229193017392 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 229193017393 glutaminase active site [active] 229193017394 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 229193017395 dimer interface [polypeptide binding]; other site 229193017396 active site 229193017397 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 229193017398 dimer interface [polypeptide binding]; other site 229193017399 active site 229193017400 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 229193017401 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 229193017402 Substrate binding site; other site 229193017403 Mg++ binding site; other site 229193017404 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 229193017405 active site 229193017406 substrate binding site [chemical binding]; other site 229193017407 CoA binding site [chemical binding]; other site 229193017408 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 229193017409 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 229193017410 gamma subunit interface [polypeptide binding]; other site 229193017411 epsilon subunit interface [polypeptide binding]; other site 229193017412 LBP interface [polypeptide binding]; other site 229193017413 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 229193017414 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 229193017415 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 229193017416 alpha subunit interaction interface [polypeptide binding]; other site 229193017417 Walker A motif; other site 229193017418 ATP binding site [chemical binding]; other site 229193017419 Walker B motif; other site 229193017420 inhibitor binding site; inhibition site 229193017421 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 229193017422 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 229193017423 core domain interface [polypeptide binding]; other site 229193017424 delta subunit interface [polypeptide binding]; other site 229193017425 epsilon subunit interface [polypeptide binding]; other site 229193017426 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 229193017427 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 229193017428 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 229193017429 beta subunit interaction interface [polypeptide binding]; other site 229193017430 Walker A motif; other site 229193017431 ATP binding site [chemical binding]; other site 229193017432 Walker B motif; other site 229193017433 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 229193017434 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 229193017435 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 229193017436 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 229193017437 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 229193017438 probable transmembrane helix predicted by TMHMM2.0 229193017439 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 229193017440 probable transmembrane helix predicted by TMHMM2.0 229193017441 probable transmembrane helix predicted by TMHMM2.0 229193017442 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 229193017443 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 229193017444 probable transmembrane helix predicted by TMHMM2.0 229193017445 probable transmembrane helix predicted by TMHMM2.0 229193017446 probable transmembrane helix predicted by TMHMM2.0 229193017447 probable transmembrane helix predicted by TMHMM2.0 229193017448 probable transmembrane helix predicted by TMHMM2.0 229193017449 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 229193017450 probable transmembrane helix predicted by TMHMM2.0 229193017451 probable transmembrane helix predicted by TMHMM2.0 229193017452 probable transmembrane helix predicted by TMHMM2.0 229193017453 probable transmembrane helix predicted by TMHMM2.0 229193017454 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 229193017455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 229193017456 S-adenosylmethionine binding site [chemical binding]; other site 229193017457 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 229193017458 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 229193017459 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 229193017460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193017461 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193017462 DNA-binding interface [nucleotide binding]; DNA binding site 229193017463 Integrase core domain; Region: rve; pfam00665 229193017464 transposase/IS protein; Provisional; Region: PRK09183 229193017465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193017466 Walker A motif; other site 229193017467 ATP binding site [chemical binding]; other site 229193017468 Walker B motif; other site 229193017469 HTH-like domain; Region: HTH_21; pfam13276 229193017470 Integrase core domain; Region: rve; pfam00665 229193017471 Integrase core domain; Region: rve; pfam00665 229193017472 PLD-like domain; Region: PLDc_2; pfam13091 229193017473 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 229193017474 putative active site [active] 229193017475 catalytic site [active] 229193017476 replication protein; Provisional; Region: PRK13702 229193017477 RepA leader peptide Tap; Provisional; Region: PRK14746 229193017478 contains replication initiation protein (Interpro|IPR003446, Biological Process: plasmid maintenance (GO:0006276)) 229193017479 replication protein; Provisional; Region: PRK13750 229193017480 ProfileScan match to entry PS50323 ARG_RICH, E-value 10.703 229193017481 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 229193017482 Tir chaperone protein (CesT); Region: CesT; cl08444 229193017483 Protein kinase domain; Region: Pkinase; pfam00069 229193017484 Catalytic domain of Protein Kinases; Region: PKc; cd00180 229193017485 active site 229193017486 ATP binding site [chemical binding]; other site 229193017487 substrate binding site [chemical binding]; other site 229193017488 activation loop (A-loop); other site 229193017489 Rac1-binding domain; Region: Rac1; pfam09632 229193017490 effector protein YopJ; Provisional; Region: PRK15371 229193017491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 229193017492 Integrase core domain; Region: rve; pfam00665 229193017493 Integrase core domain; Region: rve_3; pfam13683 229193017494 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 229193017495 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 229193017496 YopH, N-terminal; Region: YopH_N; pfam09013 229193017497 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 229193017498 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 229193017499 active site 229193017500 Integrase core domain; Region: rve; pfam00665 229193017501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 229193017502 Integrase core domain; Region: rve_3; pfam13683 229193017503 Transposase; Region: HTH_Tnp_1; pfam01527 229193017504 BlastProDom match to entry PD002176 sp_Q00931_LCRS_YERPS, E-value 7e-11 229193017505 YopH, N-terminal; Region: YopH_N; pfam09013 229193017506 type III secretion system protein; Reviewed; Region: PRK06937 229193017507 Flagellar assembly protein FliH; Region: FliH; pfam02108 229193017508 YOP proteins translocation protein K (YscK); Region: YscK; pfam06578 229193017509 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 229193017510 one probable transmembrane helix predicted for ylpB by TMHMM2.0 229193017511 type III secretion apparatus protein, YscI/HrpB, C-terminal domain; Region: yscI_hrpB_dom; TIGR02497 229193017512 type III secretion effector, YopR family; Region: type_III_yopR; TIGR02509 229193017513 type III secretion protein, YscG family; Region: type_III_yscG; TIGR02508 229193017514 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 229193017515 Protein of unknown function (DUF1895); Region: DUF1895; pfam08988 229193017516 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 229193017517 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 229193017518 phosphopeptide binding site; other site 229193017519 type III secretion system protein SsaD; Provisional; Region: PRK15367 229193017520 one probable transmembrane helix predicted for yscD by TMHMM2.0 229193017521 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 229193017522 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 229193017523 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 229193017524 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 229193017525 type III secretion system chaperone, YscB family; Region: type_III_yscB; TIGR02513 229193017526 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 229193017527 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 229193017528 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193017529 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193017530 type III secretion system chaperone YscW; Region: YscW; TIGR02567 229193017531 Type III secretory pathway, component EscU [Intracellular trafficking and secretion]; Region: EscU; COG4792 229193017532 one of 4 probable transmembrane helices predicted for yscU by TMHMM2.0 229193017533 one of 4 probable transmembrane helices predicted for yscU by TMHMM2.0 229193017534 one of 4 probable transmembrane helices predicted for yscU by TMHMM2.0 229193017535 one of 4 probable transmembrane helices predicted for yscU by TMHMM2.0 229193017536 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 229193017537 one of 6 probable transmembrane helices predicted for yscT by TMHMM2.0 229193017538 one of 6 probable transmembrane helices predicted for yscT by TMHMM2.0 229193017539 one of 6 probable transmembrane helices predicted for yscT by TMHMM2.0 229193017540 one of 6 probable transmembrane helices predicted for yscT by TMHMM2.0 229193017541 one of 6 probable transmembrane helices predicted for yscT by TMHMM2.0 229193017542 one of 6 probable transmembrane helices predicted for yscT by TMHMM2.0 229193017543 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 229193017544 one of 2 probable transmembrane helices predicted for yscS by TMHMM2.0 229193017545 one of 2 probable transmembrane helices predicted for yscS by TMHMM2.0 229193017546 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 229193017547 one of 3 probable transmembrane helices predicted for yscR by TMHMM2.0 229193017548 one of 3 probable transmembrane helices predicted for yscR by TMHMM2.0 229193017549 one of 3 probable transmembrane helices predicted for yscR by TMHMM2.0 229193017550 type III secretion system protein; Validated; Region: PRK06933 229193017551 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 229193017552 type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514 229193017553 Type III secretion protein YscO; Region: YscO; pfam07321 229193017554 type III secretion system ATPase; Provisional; Region: PRK06936 229193017555 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 229193017556 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 229193017557 Walker A motif/ATP binding site; other site 229193017558 Walker B motif; other site 229193017559 HrpJ-like domain; Region: HrpJ; cl15454 229193017560 TyeA; Region: TyeA; pfam09059 229193017561 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 229193017562 type III secretion protein, YscX family; Region: type_III_YscX; TIGR02502 229193017563 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 229193017564 BlastProDom match to entry PD029603 sp_P21209_YLC4_YEREN, E-value 1e-58 229193017565 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 229193017566 FHIPEP family; Region: FHIPEP; pfam00771 229193017567 one of 7 probable transmembrane helices predicted for yscV by TMHMM2.0 229193017568 one of 7 probable transmembrane helices predicted for yscV by TMHMM2.0 229193017569 one of 7 probable transmembrane helices predicted for yscV by TMHMM2.0 229193017570 one of 7 probable transmembrane helices predicted for yscV by TMHMM2.0 229193017571 one of 7 probable transmembrane helices predicted for yscV by TMHMM2.0 229193017572 one of 7 probable transmembrane helices predicted for yscV by TMHMM2.0 229193017573 one of 7 probable transmembrane helices predicted for yscV by TMHMM2.0 229193017574 Type III secretion system regulator (LcrR); Region: LcrR; cl09838 229193017575 type III secretion protein LcrG; Region: LcrG_PcrG; TIGR02573 229193017576 V antigen (LcrV) protein; Region: LcrV; pfam04792 229193017577 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 229193017578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 229193017579 binding surface 229193017580 TPR motif; other site 229193017581 Uncharacterized conserved protein [Function unknown]; Region: COG5613 229193017582 one of 2 probable transmembrane helices predicted for yopB by TMHMM2.0 229193017583 one of 2 probable transmembrane helices predicted for yopB by TMHMM2.0 229193017584 YopD protein; Region: YopD; pfam05844 229193017585 Integrase core domain; Region: rve; pfam00665 229193017586 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 229193017587 HMMSmart match to entry SM00364 LRR_BAC, E-value 9.2e+02 229193017588 ProfileScan match to entry PS50319 LEU_RICH, E-value 9.626 229193017589 HMMSmart match to entry SM00364 LRR_BAC, E-value 2e-05 229193017590 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.0025 229193017591 HMMSmart match to entry SM00364 LRR_BAC, E-value 2.1e-05 229193017592 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.011 229193017593 HMMSmart match to entry SM00364 LRR_BAC, E-value 6.2e-05 229193017594 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.023 229193017595 HMMSmart match to entry SM00364 LRR_BAC, E-value 2.3e-05 229193017596 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.023 229193017597 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.0017 229193017598 HMMSmart match to entry SM00364 LRR_BAC, E-value 1.8e-05 229193017599 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.0022 229193017600 HMMSmart match to entry SM00364 LRR_BAC, E-value 0.0018 229193017601 hypothetical protein; Provisional; Region: PRK11622 229193017602 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 229193017603 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; pfam03543 229193017604 one of 2 probable transmembrane helices predicted for ylpA by TMHMM2.0 229193017605 one of 2 probable transmembrane helices predicted for ylpA by TMHMM2.0 229193017606 Transposase; Region: HTH_Tnp_1; pfam01527 229193017607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 229193017608 HTH-like domain; Region: HTH_21; pfam13276 229193017609 Integrase core domain; Region: rve; pfam00665 229193017610 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 229193017611 MerR family regulatory protein; Region: MerR; pfam00376 229193017612 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 229193017613 P-loop; other site 229193017614 Magnesium ion binding site [ion binding]; other site 229193017615 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 229193017616 Magnesium ion binding site [ion binding]; other site 229193017617 plasmid-partitioning protein; Provisional; Region: PRK13698 229193017618 ParB-like nuclease domain; Region: ParB; smart00470 229193017619 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 229193017620 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 229193017621 HMMPfam match to entry PF05016 Plasmid_stabil, E-value 1e-30 229193017622 one of 2 probable transmembrane helices predicted for YPCD80 by TMHMM2.0 229193017623 one of 2 probable transmembrane helices predicted for YPCD80 by TMHMM2.0 229193017624 YopE, N terminal; Region: YopE_N; pfam09020 229193017625 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 229193017626 switch II binding region; other site 229193017627 Rac1 P-loop interaction site [polypeptide binding]; other site 229193017628 GTP binding residues [chemical binding]; other site 229193017629 switch I binding region; other site 229193017630 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 229193017631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 229193017632 Integrase core domain; Region: rve; pfam00665 229193017633 Integrase core domain; Region: rve_3; pfam13683 229193017634 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 229193017635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193017636 Integrase core domain; Region: rve; pfam00665 229193017637 Integrase core domain; Region: rve_3; cl15866 229193017638 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 229193017639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 229193017640 HTH-like domain; Region: HTH_21; pfam13276 229193017641 Integrase core domain; Region: rve; pfam00665 229193017642 Integrase core domain; Region: rve_3; pfam13683 229193017643 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193017644 DNA-binding interface [nucleotide binding]; DNA binding site 229193017645 BlastProDom match to entry PD002176 sp_Q981E7_Q981E7_RHILO. 229193017646 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 229193017647 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 229193017648 catalytic residues [active] 229193017649 catalytic nucleophile [active] 229193017650 Presynaptic Site I dimer interface [polypeptide binding]; other site 229193017651 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 229193017652 Synaptic Flat tetramer interface [polypeptide binding]; other site 229193017653 Synaptic Site I dimer interface [polypeptide binding]; other site 229193017654 DNA binding site [nucleotide binding] 229193017655 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193017656 DNA-binding interface [nucleotide binding]; DNA binding site 229193017657 one probable transmembrane helix predicted for tnpR by TMHMM2.0 229193017658 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 229193017659 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 229193017660 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 229193017661 Transposase; Region: HTH_Tnp_1; pfam01527 229193017662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 229193017663 IncFII RepA protein family; Region: IncFII_repA; cl11495 229193017664 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 229193017665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 229193017666 non-specific DNA binding site [nucleotide binding]; other site 229193017667 salt bridge; other site 229193017668 sequence-specific DNA binding site [nucleotide binding]; other site 229193017669 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), AnFA1; Region: NGN_SP_AnfA1; cd09894 229193017670 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 229193017671 N-acetyl-D-glucosamine binding site [chemical binding]; other site 229193017672 catalytic residue [active] 229193017673 one of 3 probable transmembrane helices predicted for virB2 by TMHMM2.0 229193017674 one of 3 probable transmembrane helices predicted for virB2 by TMHMM2.0 229193017675 one of 3 probable transmembrane helices predicted for virB2 by TMHMM2.0 229193017676 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 229193017677 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 229193017678 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 229193017679 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 229193017680 Type IV secretion system proteins; Region: T4SS; pfam07996 229193017681 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 229193017682 VirB8 protein; Region: VirB8; pfam04335 229193017683 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 229193017684 VirB7 interaction site; other site 229193017685 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 229193017686 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 229193017687 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 229193017688 Walker A motif; other site 229193017689 hexamer interface [polypeptide binding]; other site 229193017690 ATP binding site [chemical binding]; other site 229193017691 Walker B motif; other site 229193017692 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 229193017693 TrbM; Region: TrbM; pfam07424 229193017694 one of 1 probable transmembrane helices predicted for pCRY18 by TMHMM2.0 229193017695 haloacid dehalogenase-like hydrolase family protein; Region: PLN02770 229193017696 Haemolysin-III related; Region: HlyIII; cl03831 229193017697 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 229193017698 AAA-like domain; Region: AAA_10; pfam12846 229193017699 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 229193017700 Staphylococcal nuclease homologues; Region: SNc; smart00318 229193017701 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 229193017702 Catalytic site; other site 229193017703 one of 2 probable transmembrane helices predicted for pCRY25 by TMHMM2.0 229193017704 one of 2 probable transmembrane helices predicted for pCRY25 by TMHMM2.0 229193017705 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 229193017706 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 229193017707 SprT homologues; Region: SprT; cl01182 229193017708 SprT-like family; Region: SprT-like; pfam10263 229193017709 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 229193017710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 229193017711 sequence-specific DNA binding site [nucleotide binding]; other site 229193017712 salt bridge; other site 229193017713 one of 2 probable transmembrane helices predicted for pCRY30 by TMHMM2.0 229193017714 one of 2 probable transmembrane helices predicted for pCRY30 by TMHMM2.0 229193017715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193017716 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193017717 DNA-binding interface [nucleotide binding]; DNA binding site 229193017718 Integrase core domain; Region: rve; pfam00665 229193017719 transposase/IS protein; Provisional; Region: PRK09183 229193017720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193017721 Walker A motif; other site 229193017722 ATP binding site [chemical binding]; other site 229193017723 Walker B motif; other site 229193017724 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 229193017725 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 229193017726 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 229193017727 Phage Tail Collar Domain; Region: Collar; pfam07484 229193017728 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 229193017729 Phage-related protein, tail component [Function unknown]; Region: COG4733 229193017730 Putative phage tail protein; Region: Phage-tail_3; pfam13550 229193017731 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 229193017732 Interdomain contacts; other site 229193017733 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 229193017734 Fibronectin type III protein; Region: DUF3672; pfam12421 229193017735 Phage-related protein, tail component [Function unknown]; Region: COG4723 229193017736 one of 1 probable transmembrane helices predicted for pMT008 by TMHMM2.0 229193017737 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 229193017738 MPN+ (JAMM) motif; other site 229193017739 Zinc-binding site [ion binding]; other site 229193017740 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 229193017741 NlpC/P60 family; Region: NLPC_P60; pfam00877 229193017742 lambda-like phage minor tail protein L; Region: phage_tail_L; TIGR01600 229193017743 Phage-related protein [Function unknown]; Region: COG4718 229193017744 Mu-like prophage protein [General function prediction only]; Region: COG3941 229193017745 tape measure domain; Region: tape_meas_nterm; TIGR02675 229193017746 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 229193017747 ProfileScan match to entry PS50310 ALA_RICH, E-value 9.005 229193017748 one of 2 probable transmembrane helices predicted for pMT012 by TMHMM2.0 229193017749 one of 2 probable transmembrane helices predicted for pMT012 by TMHMM2.0 229193017750 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 229193017751 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 229193017752 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 229193017753 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 229193017754 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 229193017755 large terminase protein; Provisional; Region: 17; PHA02533 229193017756 Terminase-like family; Region: Terminase_6; pfam03237 229193017757 ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Region: COG2401 229193017758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193017759 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 229193017760 Walker A/P-loop; other site 229193017761 ATP binding site [chemical binding]; other site 229193017762 Q-loop/lid; other site 229193017763 ABC transporter signature motif; other site 229193017764 Walker B; other site 229193017765 D-loop; other site 229193017766 H-loop/switch region; other site 229193017767 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 229193017768 ParB-like nuclease domain; Region: ParBc; pfam02195 229193017769 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 229193017770 ParB-like nuclease domain; Region: ParBc; pfam02195 229193017771 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 229193017772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 229193017773 ATP binding site [chemical binding]; other site 229193017774 putative Mg++ binding site [ion binding]; other site 229193017775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 229193017776 nucleotide binding region [chemical binding]; other site 229193017777 ATP-binding site [chemical binding]; other site 229193017778 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 229193017779 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 229193017780 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 229193017781 Protein of unknown function (DUF327); Region: DUF327; cl00753 229193017782 Transposase IS200 like; Region: Y1_Tnp; pfam01797 229193017783 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 229193017784 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 229193017785 metal binding site [ion binding]; metal-binding site 229193017786 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 229193017787 dimer interface [polypeptide binding]; other site 229193017788 putative radical transfer pathway; other site 229193017789 diiron center [ion binding]; other site 229193017790 tyrosyl radical; other site 229193017791 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 229193017792 ATP cone domain; Region: ATP-cone; pfam03477 229193017793 Class I ribonucleotide reductase; Region: RNR_I; cd01679 229193017794 active site 229193017795 dimer interface [polypeptide binding]; other site 229193017796 catalytic residues [active] 229193017797 effector binding site; other site 229193017798 R2 peptide binding site; other site 229193017799 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 229193017800 active site 229193017801 putative DNA-binding cleft [nucleotide binding]; other site 229193017802 dimer interface [polypeptide binding]; other site 229193017803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193017804 endonuclease subunit; Provisional; Region: 46; PHA02562 229193017805 Walker A/P-loop; other site 229193017806 ATP binding site [chemical binding]; other site 229193017807 Q-loop/lid; other site 229193017808 ABC transporter signature motif; other site 229193017809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 229193017810 ABC transporter signature motif; other site 229193017811 Walker B; other site 229193017812 D-loop; other site 229193017813 H-loop/switch region; other site 229193017814 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 229193017815 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 229193017816 active site 229193017817 metal binding site [ion binding]; metal-binding site 229193017818 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 229193017819 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 229193017820 substrate binding pocket [chemical binding]; other site 229193017821 membrane-bound complex binding site; other site 229193017822 Initiator Replication protein; Region: Rep_3; cl03080 229193017823 one of 2 probable transmembrane helices predicted for pMT060 by TMHMM2.0 229193017824 one of 2 probable transmembrane helices predicted for pMT060 by TMHMM2.0 229193017825 hypothetical protein; Region: PHA02053 229193017826 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 229193017827 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 229193017828 SPFH domain / Band 7 family; Region: Band_7; pfam01145 229193017829 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 229193017830 one of 2 probable transmembrane helices predicted for pMT065 by TMHMM2.0 229193017831 one of 2 probable transmembrane helices predicted for pMT065 by TMHMM2.0 229193017832 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 229193017833 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 229193017834 Walker A motif; other site 229193017835 ATP binding site [chemical binding]; other site 229193017836 Walker B motif; other site 229193017837 PIN domain of bacteriophage T3, T4 RNase H, T5-5'nuclease, and homologs; Region: PIN_T4-like; cd09860 229193017838 5'-3' exonuclease; Region: 53EXOc; smart00475 229193017839 active site 229193017840 metal binding site 1 [ion binding]; metal-binding site 229193017841 5' ssDNA interaction site; other site 229193017842 3' ssDNA interaction site; other site 229193017843 metal binding site 2 [ion binding]; metal-binding site 229193017844 H3TH domain of bacteriophage T3, T4 RNase H, T5-5' nucleases, and homologs; Region: H3TH_T4-like; cd09899 229193017845 DNA binding site [nucleotide binding] 229193017846 metal binding site [ion binding]; metal-binding site 229193017847 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 229193017848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193017849 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193017850 DNA-binding interface [nucleotide binding]; DNA binding site 229193017851 Integrase core domain; Region: rve; pfam00665 229193017852 transposase/IS protein; Provisional; Region: PRK09183 229193017853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193017854 Walker A motif; other site 229193017855 ATP binding site [chemical binding]; other site 229193017856 Walker B motif; other site 229193017857 MoxR-like ATPases [General function prediction only]; Region: COG0714 229193017858 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 229193017859 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 229193017860 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 229193017861 Cobalamin biosynthesis protein CobT VWA domain; Region: CobT_C; pfam11775 229193017862 metal ion-dependent adhesion site (MIDAS); other site 229193017863 ProfileScan match to entry PS50312 ASP_RICH, E-value 13.513 229193017864 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 229193017865 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 229193017866 active site 229193017867 DNA binding site [nucleotide binding] 229193017868 Int/Topo IB signature motif; other site 229193017869 Caf1 Capsule antigen; Region: Antig_Caf1; pfam09255 229193017870 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 229193017871 PapC N-terminal domain; Region: PapC_N; pfam13954 229193017872 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 229193017873 PapC C-terminal domain; Region: PapC_C; pfam13953 229193017874 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 229193017875 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 229193017876 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 229193017877 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 229193017878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 229193017879 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 229193017880 one of 1 probable transmembrane helices predicted for pMT086 by TMHMM2.0 229193017881 Prominin; Region: Prominin; pfam05478 229193017882 one of 1 probable transmembrane helices predicted for pMT089 by TMHMM2.0 229193017883 DNA ligase; Provisional; Region: 30; PHA02587 229193017884 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 229193017885 DNA binding site [nucleotide binding] 229193017886 active site 229193017887 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 229193017888 DNA binding site [nucleotide binding] 229193017889 transposase/IS protein; Provisional; Region: PRK09183 229193017890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193017891 Walker A motif; other site 229193017892 ATP binding site [chemical binding]; other site 229193017893 Walker B motif; other site 229193017894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193017895 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193017896 DNA-binding interface [nucleotide binding]; DNA binding site 229193017897 Integrase core domain; Region: rve; pfam00665 229193017898 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 229193017899 ParB-like nuclease domain; Region: ParBc; pfam02195 229193017900 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 229193017901 Antirestriction protein [General function prediction only]; Region: ArdA; COG4734 229193017902 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 229193017903 putative methylase; Provisional; Region: PRK13699 229193017904 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 229193017905 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 229193017906 ProfileScan match to entry PS50324 SER_RICH, E-value 9.520 229193017907 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 229193017908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193017909 Walker A motif; other site 229193017910 ATP binding site [chemical binding]; other site 229193017911 Walker B motif; other site 229193017912 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 229193017913 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 229193017914 ParB-like nuclease domain; Region: ParB; smart00470 229193017915 ParB family; Region: ParB; pfam08775 229193017916 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 229193017917 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 229193017918 P-loop; other site 229193017919 Magnesium ion binding site [ion binding]; other site 229193017920 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 229193017921 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 229193017922 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 229193017923 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 229193017924 catalytic residues [active] 229193017925 catalytic nucleophile [active] 229193017926 Uncharacterized conserved protein [Function unknown]; Region: COG5464 229193017927 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 229193017928 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 229193017929 Putative catalytic domain, repeat 1, of Yersinia pestis murine toxin-like proteins; Region: PLDc_Ymt_1; cd09150 229193017930 putative active site [active] 229193017931 catalytic site [active] 229193017932 Putative catalytic domain, repeat 2, of Yersinia pestis murine toxin-like proteins; Region: PLDc_Ymt_2; cd09151 229193017933 PLD-like domain; Region: PLDc_2; pfam13091 229193017934 putative active site [active] 229193017935 catalytic site [active] 229193017936 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 229193017937 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 229193017938 putative transposase OrfB; Reviewed; Region: PHA02517 229193017939 Uncharacterized conserved protein [Function unknown]; Region: COG5464 229193017940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 229193017941 Transposase; Region: DEDD_Tnp_IS110; pfam01548 229193017942 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 229193017943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 229193017944 MULE transposase domain; Region: MULE; pfam10551 229193017945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 229193017946 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 229193017947 DNA-binding interface [nucleotide binding]; DNA binding site 229193017948 Integrase core domain; Region: rve; pfam00665 229193017949 transposase/IS protein; Provisional; Region: PRK09183 229193017950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 229193017951 Walker A motif; other site 229193017952 ATP binding site [chemical binding]; other site 229193017953 Walker B motif; other site 229193017954 Rop protein; Region: Rop; pfam01815 229193017955 ProfileScan match to entry PS50323 ARG_RICH, E-value 8.981 229193017956 Pesticin Translocation And Receptor Binding Domain; Region: Pesticin_RB; cd12220 229193017957 TonB box [polypeptide binding]; other site 229193017958 outer membrane protease; Reviewed; Region: PRK12580 229193017959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 229193017960 non-specific DNA binding site [nucleotide binding]; other site 229193017961 salt bridge; other site 229193017962 sequence-specific DNA binding site [nucleotide binding]; other site 229193017963 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470