-- dump date 20140620_141626 -- class Genbank::misc_feature -- table misc_feature_note -- id note 273123000001 Protein kinase domain; Region: Pkinase; pfam00069 273123000002 Catalytic domain of Protein Kinases; Region: PKc; cd00180 273123000003 active site 273123000004 ATP binding site [chemical binding]; other site 273123000005 substrate binding site [chemical binding]; other site 273123000006 activation loop (A-loop); other site 273123000007 Rac1-binding domain; Region: Rac1; pfam09632 273123000008 Tir chaperone protein (CesT); Region: CesT; cl08444 273123000009 Integrase core domain; Region: rve; pfam00665 273123000010 Integrase core domain; Region: rve_3; cl15866 273123000011 replication protein; Provisional; Region: PRK13750 273123000012 replication protein; Provisional; Region: PRK13702 273123000013 Integrase core domain; Region: rve; pfam00665 273123000014 Transposase; Region: HTH_Tnp_1; pfam01527 273123000015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 273123000016 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 273123000017 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 273123000018 trimer interface [polypeptide binding]; other site 273123000019 YadA-like C-terminal region; Region: YadA; pfam03895 273123000020 similar to N-term of Y. pestis YPCD1.89 273123000021 similar to C-term of Y. pestis YPCD1.89 273123000022 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 273123000023 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 273123000024 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 273123000025 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 273123000026 catalytic residues [active] 273123000027 catalytic nucleophile [active] 273123000028 Presynaptic Site I dimer interface [polypeptide binding]; other site 273123000029 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 273123000030 Synaptic Flat tetramer interface [polypeptide binding]; other site 273123000031 Synaptic Site I dimer interface [polypeptide binding]; other site 273123000032 DNA binding site [nucleotide binding] 273123000033 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 273123000034 DNA-binding interface [nucleotide binding]; DNA binding site 273123000035 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 273123000036 DNA-binding interface [nucleotide binding]; DNA binding site 273123000037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 273123000038 HTH-like domain; Region: HTH_21; pfam13276 273123000039 Integrase core domain; Region: rve; pfam00665 273123000040 Integrase core domain; Region: rve_3; pfam13683 273123000041 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 273123000042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123000043 Walker A motif; other site 273123000044 ATP binding site [chemical binding]; other site 273123000045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 273123000046 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 273123000047 Integrase core domain; Region: rve; pfam00665 273123000048 Integrase core domain; Region: rve_3; cl15866 273123000049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 273123000050 Integrase core domain; Region: rve; pfam00665 273123000051 Integrase core domain; Region: rve_3; pfam13683 273123000052 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 273123000053 YopE, N terminal; Region: YopE_N; pfam09020 273123000054 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 273123000055 switch II binding region; other site 273123000056 Rac1 P-loop interaction site [polypeptide binding]; other site 273123000057 GTP binding residues [chemical binding]; other site 273123000058 switch I binding region; other site 273123000059 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 273123000060 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 273123000061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 273123000062 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 273123000063 plasmid-partitioning protein; Provisional; Region: PRK13698 273123000064 ParB-like nuclease domain; Region: ParB; smart00470 273123000065 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 273123000066 MerR family regulatory protein; Region: MerR; pfam00376 273123000067 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 273123000068 P-loop; other site 273123000069 Magnesium ion binding site [ion binding]; other site 273123000070 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 273123000071 Magnesium ion binding site [ion binding]; other site 273123000072 Integrase core domain; Region: rve_3; cl15866 273123000073 HTH-like domain; Region: HTH_21; pfam13276 273123000074 Integrase core domain; Region: rve; pfam00665 273123000075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 273123000076 Transposase; Region: HTH_Tnp_1; cl17663 273123000079 glycine dehydrogenase; Provisional; Region: PRK12566 273123000080 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; pfam03543 273123000081 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 273123000082 DDE domain; Region: DDE_Tnp_IS240; pfam13610 273123000083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 273123000084 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 273123000085 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 273123000086 Leucine-rich repeats; other site 273123000087 Substrate binding site [chemical binding]; other site 273123000088 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 273123000089 Integrase core domain; Region: rve; pfam00665 273123000090 YopD protein; Region: YopD; pfam05844 273123000091 Uncharacterized conserved protein [Function unknown]; Region: COG5613 273123000092 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 273123000093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273123000094 binding surface 273123000095 TPR motif; other site 273123000096 V antigen (LcrV) protein; Region: LcrV; pfam04792 273123000097 type III secretion protein LcrG; Region: LcrG_PcrG; TIGR02573 273123000098 Type III secretion system regulator (LcrR); Region: LcrR; cl09838 273123000099 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 273123000100 FHIPEP family; Region: FHIPEP; pfam00771 273123000101 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 273123000102 type III secretion protein, YscX family; Region: type_III_YscX; TIGR02502 273123000103 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 273123000104 TyeA; Region: TyeA; pfam09059 273123000105 HrpJ-like domain; Region: HrpJ; cl15454 273123000106 type III secretion system ATPase; Provisional; Region: PRK06936 273123000107 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 273123000108 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 273123000109 Walker A motif/ATP binding site; other site 273123000110 Walker B motif; other site 273123000111 Type III secretion protein YscO; Region: YscO; pfam07321 273123000112 type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514 273123000113 type III secretion system protein; Validated; Region: PRK06933 273123000114 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 273123000115 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 273123000116 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 273123000117 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 273123000118 Type III secretory pathway, component EscU [Intracellular trafficking and secretion]; Region: EscU; COG4792 273123000119 type III secretion system chaperone YscW; Region: YscW; TIGR02567 273123000120 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 273123000121 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 273123000122 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123000123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123000124 type III secretion system chaperone, YscB family; Region: type_III_yscB; TIGR02513 273123000125 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 273123000126 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 273123000127 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 273123000128 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 273123000129 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 273123000130 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 273123000131 phosphopeptide binding site; other site 273123000132 type III secretion system protein SsaD; Provisional; Region: PRK15367 273123000133 Protein of unknown function (DUF1895); Region: DUF1895; pfam08988 273123000134 type III secretion apparatus needle protein; Region: III_needle; TIGR02105 273123000135 type III secretion protein, YscG family; Region: type_III_yscG; TIGR02508 273123000136 type III secretion effector, YopR family; Region: type_III_yopR; TIGR02509 273123000137 type III secretion apparatus protein, YscI/HrpB, C-terminal domain; Region: yscI_hrpB_dom; TIGR02497 273123000138 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 273123000139 YOP proteins translocation protein K (YscK); Region: YscK; pfam06578 273123000140 type III secretion system protein; Reviewed; Region: PRK06937 273123000141 Flagellar assembly protein FliH; Region: FliH; pfam02108 273123000142 YopH, N-terminal; Region: YopH_N; pfam09013 273123000143 Transposase; Region: HTH_Tnp_1; pfam01527 273123000144 Integrase core domain; Region: rve; pfam00665 273123000145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 273123000146 YopH, N-terminal; Region: YopH_N; pfam09013 273123000147 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 273123000148 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 273123000149 active site 273123000150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 273123000151 Integrase core domain; Region: rve; pfam00665 273123000152 Integrase core domain; Region: rve_3; pfam13683 273123000153 effector protein YopJ; Provisional; Region: PRK15371 273123000154 Initiator Replication protein; Region: Rep_3; pfam01051 273123000155 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 273123000156 N-acetyl-D-glucosamine binding site [chemical binding]; other site 273123000157 catalytic residue [active] 273123000158 TrbC/VIRB2 family; Region: TrbC; pfam04956 273123000159 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 273123000160 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 273123000161 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 273123000162 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 273123000163 Type IV secretion system proteins; Region: T4SS; pfam07996 273123000164 antitoxin YefM; Provisional; Region: PRK11409 273123000165 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 273123000166 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 273123000167 VirB8 protein; Region: VirB8; pfam04335 273123000168 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 273123000169 VirB7 interaction site; other site 273123000170 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 273123000171 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 273123000172 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 273123000173 Walker A motif; other site 273123000174 hexamer interface [polypeptide binding]; other site 273123000175 ATP binding site [chemical binding]; other site 273123000176 Walker B motif; other site 273123000177 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 273123000178 YadA-like C-terminal region; Region: YadA; pfam03895 273123000179 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 273123000180 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 273123000181 N-terminal fragment of TriK gene 273123000182 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 273123000183 DNA topoisomerase III; Provisional; Region: PRK07726 273123000184 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 273123000185 active site 273123000186 putative interdomain interaction site [polypeptide binding]; other site 273123000187 putative metal-binding site [ion binding]; other site 273123000188 putative nucleotide binding site [chemical binding]; other site 273123000189 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 273123000190 domain I; other site 273123000191 DNA binding groove [nucleotide binding] 273123000192 phosphate binding site [ion binding]; other site 273123000193 domain II; other site 273123000194 domain III; other site 273123000195 nucleotide binding site [chemical binding]; other site 273123000196 catalytic site [active] 273123000197 domain IV; other site 273123000198 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 273123000199 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 273123000200 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 273123000201 ParA-like protein; Provisional; Region: PHA02518 273123000202 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 273123000203 P-loop; other site 273123000204 Magnesium ion binding site [ion binding]; other site 273123000205 Antitoxin ParD; Region: ParD; pfam09386 273123000206 FMN-binding protein MioC; Provisional; Region: PRK09004 273123000207 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 273123000208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273123000209 putative DNA binding site [nucleotide binding]; other site 273123000210 putative Zn2+ binding site [ion binding]; other site 273123000211 AsnC family; Region: AsnC_trans_reg; pfam01037 273123000212 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 273123000213 motif 1; other site 273123000214 dimer interface [polypeptide binding]; other site 273123000215 active site 273123000216 motif 2; other site 273123000217 motif 3; other site 273123000218 hypothetical protein; Provisional; Region: yieM; PRK10997 273123000219 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 273123000220 metal ion-dependent adhesion site (MIDAS); other site 273123000221 regulatory ATPase RavA; Provisional; Region: PRK13531 273123000222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123000223 Walker A motif; other site 273123000224 ATP binding site [chemical binding]; other site 273123000225 Walker B motif; other site 273123000226 arginine finger; other site 273123000227 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 273123000228 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 273123000229 potassium uptake protein; Region: kup; TIGR00794 273123000230 12 probable transmembrane helices predicted by TMHMM2.0 273123000231 D-ribose pyranase; Provisional; Region: PRK11797 273123000232 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 273123000233 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 273123000234 substrate binding site [chemical binding]; other site 273123000235 dimer interface [polypeptide binding]; other site 273123000236 ATP binding site [chemical binding]; other site 273123000237 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 273123000238 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 273123000239 putative transporter; Provisional; Region: PRK10504 273123000240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123000241 putative substrate translocation pore; other site 273123000242 14 probable transmembrane helices predicted by TMHMM2.0 273123000243 Transcriptional regulators [Transcription]; Region: FadR; COG2186 273123000244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123000245 DNA-binding site [nucleotide binding]; DNA binding site 273123000246 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 273123000247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 273123000248 MULE transposase domain; Region: MULE; pfam10551 273123000249 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 273123000250 Walker A motif; other site 273123000251 similar to Yersinia pestis YPO0013 mobA, mob, chlB, nar; molybdopterin-guanine dinucleotide biosynthesis protein A (97.5% evalue=1.E-39); Escherichia coli b3857 mobA; molybdopterin-guanine dinucleotide biosynthesis protein A (52.5% evalue=3.E-19);pseudogene of molybdopterin-guanine dinucleotidebiosynthesis protein A 273123000252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3084 273123000253 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 273123000254 serine/threonine protein kinase; Provisional; Region: PRK11768 273123000255 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 273123000256 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 273123000257 catalytic residues [active] 273123000258 hinge region; other site 273123000259 alpha helical domain; other site 273123000260 1 probable transmembrane helix predicted by TMHMM2.0 273123000261 DNA polymerase I; Provisional; Region: PRK05755 273123000262 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 273123000263 active site 273123000264 metal binding site 1 [ion binding]; metal-binding site 273123000265 putative 5' ssDNA interaction site; other site 273123000266 metal binding site 3; metal-binding site 273123000267 metal binding site 2 [ion binding]; metal-binding site 273123000268 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 273123000269 putative DNA binding site [nucleotide binding]; other site 273123000270 putative metal binding site [ion binding]; other site 273123000271 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 273123000272 active site 273123000273 catalytic site [active] 273123000274 substrate binding site [chemical binding]; other site 273123000275 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 273123000276 active site 273123000277 DNA binding site [nucleotide binding] 273123000278 catalytic site [active] 273123000279 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 273123000280 G1 box; other site 273123000281 GTP/Mg2+ binding site [chemical binding]; other site 273123000282 Switch I region; other site 273123000283 G2 box; other site 273123000284 G3 box; other site 273123000285 Switch II region; other site 273123000286 G4 box; other site 273123000287 G5 box; other site 273123000288 Der GTPase activator; Provisional; Region: PRK05244 273123000289 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 273123000290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123000291 FeS/SAM binding site; other site 273123000292 HemN C-terminal domain; Region: HemN_C; pfam06969 273123000293 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 273123000294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123000295 active site 273123000296 phosphorylation site [posttranslational modification] 273123000297 intermolecular recognition site; other site 273123000298 dimerization interface [polypeptide binding]; other site 273123000299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123000300 Walker A motif; other site 273123000301 ATP binding site [chemical binding]; other site 273123000302 Walker B motif; other site 273123000303 arginine finger; other site 273123000304 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 273123000305 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 273123000306 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 273123000307 dimer interface [polypeptide binding]; other site 273123000308 phosphorylation site [posttranslational modification] 273123000309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123000310 ATP binding site [chemical binding]; other site 273123000311 Mg2+ binding site [ion binding]; other site 273123000312 G-X-G motif; other site 273123000313 glutamine synthetase; Provisional; Region: glnA; PRK09469 273123000314 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 273123000315 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 273123000316 similar to Yersinia pestis YPO0025 with a frameshift. 273123000317 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 273123000318 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 273123000319 G1 box; other site 273123000320 putative GEF interaction site [polypeptide binding]; other site 273123000321 GTP/Mg2+ binding site [chemical binding]; other site 273123000322 Switch I region; other site 273123000323 G2 box; other site 273123000324 G3 box; other site 273123000325 Switch II region; other site 273123000326 G4 box; other site 273123000327 G5 box; other site 273123000328 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 273123000329 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 273123000330 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 273123000331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123000332 motif II; other site 273123000333 hypothetical protein; Reviewed; Region: PRK01637 273123000334 6 probable transmembrane helices predicted by TMHMM2.0 273123000335 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 273123000336 putative active site [active] 273123000337 dimerization interface [polypeptide binding]; other site 273123000338 putative tRNAtyr binding site [nucleotide binding]; other site 273123000339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273123000340 Coenzyme A binding pocket [chemical binding]; other site 273123000341 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 273123000342 1 probable transmembrane helix predicted by TMHMM2.0 273123000343 AsmA family; Region: AsmA; pfam05170 273123000344 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 273123000345 1 probable transmembrane helix predicted by TMHMM2.0 273123000346 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 273123000347 11 probable transmembrane helices predicted by TMHMM2.0 273123000348 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 273123000349 11 probable transmembrane helices predicted by TMHMM2.0 273123000350 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 273123000351 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 273123000352 generic binding surface II; other site 273123000353 ssDNA binding site; other site 273123000354 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273123000355 ATP binding site [chemical binding]; other site 273123000356 putative Mg++ binding site [ion binding]; other site 273123000357 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123000358 nucleotide binding region [chemical binding]; other site 273123000359 ATP-binding site [chemical binding]; other site 273123000360 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 273123000361 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 273123000362 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 273123000363 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 273123000364 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273123000365 Zn2+ binding site [ion binding]; other site 273123000366 Mg2+ binding site [ion binding]; other site 273123000367 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 273123000368 synthetase active site [active] 273123000369 NTP binding site [chemical binding]; other site 273123000370 metal binding site [ion binding]; metal-binding site 273123000371 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 273123000372 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 273123000373 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 273123000374 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 273123000375 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 273123000376 catalytic site [active] 273123000377 G-X2-G-X-G-K; other site 273123000378 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 273123000379 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 273123000380 nucleotide binding pocket [chemical binding]; other site 273123000381 K-X-D-G motif; other site 273123000382 catalytic site [active] 273123000383 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 273123000384 Predicted membrane protein [Function unknown]; Region: COG2860 273123000385 UPF0126 domain; Region: UPF0126; pfam03458 273123000386 UPF0126 domain; Region: UPF0126; pfam03458 273123000387 7 probable transmembrane helices predicted by TMHMM2.0 273123000388 hypothetical protein; Provisional; Region: PRK11820 273123000389 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 273123000390 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 273123000391 ribonuclease PH; Reviewed; Region: rph; PRK00173 273123000392 Ribonuclease PH; Region: RNase_PH_bact; cd11362 273123000393 hexamer interface [polypeptide binding]; other site 273123000394 active site 273123000395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273123000396 active site 273123000397 division inhibitor protein; Provisional; Region: slmA; PRK09480 273123000398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 273123000399 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 273123000400 trimer interface [polypeptide binding]; other site 273123000401 active site 273123000402 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 273123000403 Flavoprotein; Region: Flavoprotein; pfam02441 273123000404 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 273123000405 hypothetical protein; Reviewed; Region: PRK00024 273123000406 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 273123000407 MPN+ (JAMM) motif; other site 273123000408 Zinc-binding site [ion binding]; other site 273123000409 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 273123000410 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 273123000411 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 273123000412 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 273123000413 DNA binding site [nucleotide binding] 273123000414 catalytic residue [active] 273123000415 H2TH interface [polypeptide binding]; other site 273123000416 putative catalytic residues [active] 273123000417 turnover-facilitating residue; other site 273123000418 intercalation triad [nucleotide binding]; other site 273123000419 8OG recognition residue [nucleotide binding]; other site 273123000420 putative reading head residues; other site 273123000421 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 273123000422 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 273123000423 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 273123000424 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 273123000425 active site 273123000426 (T/H)XGH motif; other site 273123000427 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 273123000428 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 273123000429 putative metal binding site; other site 273123000430 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 273123000431 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 273123000432 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 273123000433 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 273123000434 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 273123000435 putative active site [active] 273123000436 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 273123000437 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 273123000438 putative active site [active] 273123000439 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 273123000440 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 273123000441 NADP binding site [chemical binding]; other site 273123000442 homopentamer interface [polypeptide binding]; other site 273123000443 substrate binding site [chemical binding]; other site 273123000444 active site 273123000445 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 273123000446 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 273123000447 substrate-cofactor binding pocket; other site 273123000448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123000449 catalytic residue [active] 273123000450 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 273123000451 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 273123000452 NAD(P) binding site [chemical binding]; other site 273123000453 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 273123000454 NodB motif; other site 273123000455 putative active site [active] 273123000456 putative catalytic site [active] 273123000457 Zn binding site [ion binding]; other site 273123000458 AmiB activator; Provisional; Region: PRK11637 273123000459 Peptidase family M23; Region: Peptidase_M23; pfam01551 273123000460 phosphoglyceromutase; Provisional; Region: PRK05434 273123000461 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 273123000462 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 273123000463 active site residue [active] 273123000464 1 probable transmembrane helix predicted by TMHMM2.0 273123000465 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 273123000466 GSH binding site [chemical binding]; other site 273123000467 catalytic residues [active] 273123000468 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 273123000469 SecA binding site; other site 273123000470 Preprotein binding site; other site 273123000471 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 273123000472 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 273123000473 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 273123000474 serine acetyltransferase; Provisional; Region: cysE; PRK11132 273123000475 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 273123000476 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 273123000477 trimer interface [polypeptide binding]; other site 273123000478 active site 273123000479 substrate binding site [chemical binding]; other site 273123000480 CoA binding site [chemical binding]; other site 273123000481 putative rRNA methylase; Provisional; Region: PRK10358 273123000482 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 273123000483 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 273123000484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123000485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123000486 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 273123000487 DNA binding site [nucleotide binding] 273123000488 active site 273123000489 two-component sensor protein; Provisional; Region: cpxA; PRK09470 273123000490 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 273123000491 dimerization interface [polypeptide binding]; other site 273123000492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123000493 dimer interface [polypeptide binding]; other site 273123000494 phosphorylation site [posttranslational modification] 273123000495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123000496 ATP binding site [chemical binding]; other site 273123000497 Mg2+ binding site [ion binding]; other site 273123000498 G-X-G motif; other site 273123000499 2 probable transmembrane helices predicted by TMHMM2.0 273123000500 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 273123000501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123000502 active site 273123000503 phosphorylation site [posttranslational modification] 273123000504 intermolecular recognition site; other site 273123000505 dimerization interface [polypeptide binding]; other site 273123000506 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123000507 DNA binding site [nucleotide binding] 273123000508 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 273123000509 dimer interface [polypeptide binding]; other site 273123000510 Uncharacterized conserved protein [Function unknown]; Region: COG5464 273123000511 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 273123000512 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 273123000513 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 273123000514 6 probable transmembrane helices predicted by TMHMM2.0 273123000515 6-phosphofructokinase; Provisional; Region: PRK03202 273123000516 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 273123000517 active site 273123000518 ADP/pyrophosphate binding site [chemical binding]; other site 273123000519 dimerization interface [polypeptide binding]; other site 273123000520 allosteric effector site; other site 273123000521 fructose-1,6-bisphosphate binding site; other site 273123000522 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 273123000523 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123000524 substrate binding pocket [chemical binding]; other site 273123000525 membrane-bound complex binding site; other site 273123000526 hinge residues; other site 273123000527 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 273123000528 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 273123000529 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 273123000530 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 273123000531 transmembrane helices; other site 273123000532 11 probable transmembrane helices predicted by TMHMM2.0 273123000533 hypothetical protein; Validated; Region: PRK06201 273123000534 hypothetical protein; Provisional; Region: PRK09262 273123000535 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 273123000536 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123000537 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123000538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123000539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123000540 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273123000541 dimerization interface [polypeptide binding]; other site 273123000542 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 273123000543 triosephosphate isomerase; Provisional; Region: PRK14567 273123000544 substrate binding site [chemical binding]; other site 273123000545 dimer interface [polypeptide binding]; other site 273123000546 catalytic triad [active] 273123000547 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 273123000548 1 probable transmembrane helix predicted by TMHMM2.0 273123000549 Predicted membrane protein [Function unknown]; Region: COG3152 273123000550 4 probable transmembrane helices predicted by TMHMM2.0 273123000551 ferredoxin-NADP reductase; Provisional; Region: PRK10926 273123000552 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 273123000553 FAD binding pocket [chemical binding]; other site 273123000554 FAD binding motif [chemical binding]; other site 273123000555 phosphate binding motif [ion binding]; other site 273123000556 beta-alpha-beta structure motif; other site 273123000557 NAD binding pocket [chemical binding]; other site 273123000558 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 273123000559 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 273123000560 putative active site [active] 273123000561 glycerol kinase; Provisional; Region: glpK; PRK00047 273123000562 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 273123000563 N- and C-terminal domain interface [polypeptide binding]; other site 273123000564 active site 273123000565 MgATP binding site [chemical binding]; other site 273123000566 catalytic site [active] 273123000567 metal binding site [ion binding]; metal-binding site 273123000568 glycerol binding site [chemical binding]; other site 273123000569 homotetramer interface [polypeptide binding]; other site 273123000570 homodimer interface [polypeptide binding]; other site 273123000571 FBP binding site [chemical binding]; other site 273123000572 protein IIAGlc interface [polypeptide binding]; other site 273123000573 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 273123000574 amphipathic channel; other site 273123000575 Asn-Pro-Ala signature motifs; other site 273123000576 6 probable transmembrane helices predicted by TMHMM2.0 273123000577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 273123000578 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 273123000579 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 273123000580 putative active site [active] 273123000581 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273123000582 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 273123000583 Walker A/P-loop; other site 273123000584 ATP binding site [chemical binding]; other site 273123000585 Q-loop/lid; other site 273123000586 ABC transporter signature motif; other site 273123000587 Walker B; other site 273123000588 D-loop; other site 273123000589 H-loop/switch region; other site 273123000590 5 probable transmembrane helices predicted by TMHMM2.0 273123000591 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 273123000592 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123000593 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123000594 1 probable transmembrane helix predicted by TMHMM2.0 273123000595 1 probable transmembrane helix predicted by TMHMM2.0 273123000596 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 273123000597 1 probable transmembrane helix predicted by TMHMM2.0 273123000598 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 273123000599 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 273123000600 UbiA prenyltransferase family; Region: UbiA; pfam01040 273123000601 8 probable transmembrane helices predicted by TMHMM2.0 273123000602 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 273123000603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123000604 Walker A motif; other site 273123000605 ATP binding site [chemical binding]; other site 273123000606 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 273123000607 Walker B motif; other site 273123000608 arginine finger; other site 273123000609 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 273123000610 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 273123000611 active site 273123000612 HslU subunit interaction site [polypeptide binding]; other site 273123000613 1 probable transmembrane helix predicted by TMHMM2.0 273123000614 Sporulation related domain; Region: SPOR; cl10051 273123000615 cell division protein FtsN; Provisional; Region: PRK12757 273123000616 1 probable transmembrane helix predicted by TMHMM2.0 273123000617 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123000618 DNA binding site [nucleotide binding] 273123000619 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 273123000620 domain linker motif; other site 273123000621 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 273123000622 dimerization interface [polypeptide binding]; other site 273123000623 ligand binding site [chemical binding]; other site 273123000624 primosome assembly protein PriA; Validated; Region: PRK05580 273123000625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273123000626 ATP binding site [chemical binding]; other site 273123000627 putative Mg++ binding site [ion binding]; other site 273123000628 helicase superfamily c-terminal domain; Region: HELICc; smart00490 273123000629 ATP-binding site [chemical binding]; other site 273123000630 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 273123000631 Predicted membrane protein [Function unknown]; Region: COG4682 273123000632 yiaA/B two helix domain; Region: YiaAB; pfam05360 273123000633 yiaA/B two helix domain; Region: YiaAB; pfam05360 273123000634 4 probable transmembrane helices predicted by TMHMM2.0 273123000635 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 273123000636 dimerization interface [polypeptide binding]; other site 273123000637 DNA binding site [nucleotide binding] 273123000638 corepressor binding sites; other site 273123000639 cystathionine gamma-synthase; Provisional; Region: PRK08045 273123000640 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 273123000641 homodimer interface [polypeptide binding]; other site 273123000642 substrate-cofactor binding pocket; other site 273123000643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123000644 catalytic residue [active] 273123000645 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 273123000646 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 273123000647 putative catalytic residues [active] 273123000648 putative nucleotide binding site [chemical binding]; other site 273123000649 putative aspartate binding site [chemical binding]; other site 273123000650 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 273123000651 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 273123000652 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 273123000653 FAD binding site [chemical binding]; other site 273123000654 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 273123000655 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 273123000656 acetylornithine deacetylase; Provisional; Region: PRK05111 273123000657 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 273123000658 metal binding site [ion binding]; metal-binding site 273123000659 putative dimer interface [polypeptide binding]; other site 273123000660 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 273123000661 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 273123000662 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 273123000663 nucleotide binding site [chemical binding]; other site 273123000664 N-acetyl-L-glutamate binding site [chemical binding]; other site 273123000665 argininosuccinate lyase; Provisional; Region: PRK04833 273123000666 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 273123000667 active sites [active] 273123000668 tetramer interface [polypeptide binding]; other site 273123000669 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 273123000670 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 273123000671 N-terminal plug; other site 273123000672 ligand-binding site [chemical binding]; other site 273123000673 Heme-binding protein A (HasA); Region: HasA; pfam06438 273123000674 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 273123000675 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 273123000676 Walker A/P-loop; other site 273123000677 ATP binding site [chemical binding]; other site 273123000678 Q-loop/lid; other site 273123000679 ABC transporter signature motif; other site 273123000680 Walker B; other site 273123000681 D-loop; other site 273123000682 H-loop/switch region; other site 273123000683 5 probable transmembrane helices predicted by TMHMM2.0 273123000684 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 273123000685 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123000686 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123000687 1 probable transmembrane helix predicted by TMHMM2.0 273123000688 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 273123000689 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 273123000690 1 probable transmembrane helix predicted by TMHMM2.0 273123000691 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 273123000692 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273123000693 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273123000694 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 273123000695 catalytic triad [active] 273123000696 dimer interface [polypeptide binding]; other site 273123000697 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 273123000698 GSH binding site [chemical binding]; other site 273123000699 catalytic residues [active] 273123000700 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 273123000701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123000702 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 273123000703 dimerization interface [polypeptide binding]; other site 273123000704 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 273123000705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273123000706 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273123000707 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 273123000708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 273123000709 hypothetical protein; Provisional; Region: PRK11056 273123000710 4 probable transmembrane helices predicted by TMHMM2.0 273123000711 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 273123000712 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 273123000713 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 273123000714 N-terminal plug; other site 273123000715 ligand-binding site [chemical binding]; other site 273123000716 glutamate racemase; Provisional; Region: PRK00865 273123000717 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 273123000718 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 273123000719 putative ligand binding site [chemical binding]; other site 273123000720 1 probable transmembrane helix predicted by TMHMM2.0 273123000721 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123000722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123000723 Walker A/P-loop; other site 273123000724 ATP binding site [chemical binding]; other site 273123000725 Q-loop/lid; other site 273123000726 ABC transporter signature motif; other site 273123000727 Walker B; other site 273123000728 D-loop; other site 273123000729 H-loop/switch region; other site 273123000730 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123000731 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123000732 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123000733 TM-ABC transporter signature motif; other site 273123000734 8 probable transmembrane helices predicted by TMHMM2.0 273123000735 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123000736 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123000737 TM-ABC transporter signature motif; other site 273123000738 9 probable transmembrane helices predicted by TMHMM2.0 273123000739 transcriptional regulator HdfR; Provisional; Region: PRK03601 273123000740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123000741 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 273123000742 dimerization interface [polypeptide binding]; other site 273123000743 hypothetical protein; Provisional; Region: PRK11027 273123000744 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 273123000745 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 273123000746 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 273123000747 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 273123000748 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 273123000749 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 273123000750 PYR/PP interface [polypeptide binding]; other site 273123000751 dimer interface [polypeptide binding]; other site 273123000752 TPP binding site [chemical binding]; other site 273123000753 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 273123000754 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 273123000755 TPP-binding site [chemical binding]; other site 273123000756 dimer interface [polypeptide binding]; other site 273123000757 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 273123000758 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 273123000759 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 273123000760 homodimer interface [polypeptide binding]; other site 273123000761 substrate-cofactor binding pocket; other site 273123000762 catalytic residue [active] 273123000763 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 273123000764 threonine dehydratase; Reviewed; Region: PRK09224 273123000765 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 273123000766 tetramer interface [polypeptide binding]; other site 273123000767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123000768 catalytic residue [active] 273123000769 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 273123000770 putative Ile/Val binding site [chemical binding]; other site 273123000771 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 273123000772 putative Ile/Val binding site [chemical binding]; other site 273123000773 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 273123000774 1 probable transmembrane helix predicted by TMHMM2.0 273123000775 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 273123000776 1 probable transmembrane helix predicted by TMHMM2.0 273123000777 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 273123000778 1 probable transmembrane helix predicted by TMHMM2.0 273123000779 conserved hypothetical protein; Region: TIGR03034 273123000780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123000781 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 273123000782 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 273123000783 putative dimerization interface [polypeptide binding]; other site 273123000784 ketol-acid reductoisomerase; Validated; Region: PRK05225 273123000785 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 273123000786 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 273123000787 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 273123000788 similar to Yersinia pestis YPO3886 colicin (partial) (99.3% evalue=0); Ralstonia solanacearum RS01806 probable transmembrane protein (43.4% evalue=6.E-21);colicin (partial) 273123000789 similar to Yersinia pestis YPO3884 colicin (partial) (52.2% evalue=6.E-16); Pseudomonas aeruginosa PA1150 pys2; pyocin S2 (43.5% evalue=9.E-09);colicin (partial) 273123000790 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 273123000791 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 273123000792 active site 273123000793 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 273123000794 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 273123000795 active site 273123000796 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 273123000797 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 273123000798 1 probable transmembrane helix predicted by TMHMM2.0 273123000799 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 273123000800 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 273123000801 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 273123000802 1 probable transmembrane helix predicted by TMHMM2.0 273123000803 Fimbrial protein; Region: Fimbrial; cl01416 273123000804 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 273123000805 PapC N-terminal domain; Region: PapC_N; pfam13954 273123000806 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 273123000807 PapC C-terminal domain; Region: PapC_C; pfam13953 273123000808 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 273123000809 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 273123000810 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 273123000811 1 probable transmembrane helix predicted by TMHMM2.0 273123000812 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 273123000813 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 273123000814 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 273123000815 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 273123000816 Part of AAA domain; Region: AAA_19; pfam13245 273123000817 Family description; Region: UvrD_C_2; pfam13538 273123000818 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 273123000819 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 273123000820 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 273123000821 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 273123000822 ATP binding site [chemical binding]; other site 273123000823 Mg++ binding site [ion binding]; other site 273123000824 motif III; other site 273123000825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123000826 nucleotide binding region [chemical binding]; other site 273123000827 ATP-binding site [chemical binding]; other site 273123000828 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273123000829 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 273123000830 catalytic residues [active] 273123000831 transcription termination factor Rho; Provisional; Region: rho; PRK09376 273123000832 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 273123000833 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 273123000834 RNA binding site [nucleotide binding]; other site 273123000835 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 273123000836 multimer interface [polypeptide binding]; other site 273123000837 Walker A motif; other site 273123000838 ATP binding site [chemical binding]; other site 273123000839 Walker B motif; other site 273123000840 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 273123000841 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 273123000842 Mg++ binding site [ion binding]; other site 273123000843 putative catalytic motif [active] 273123000844 substrate binding site [chemical binding]; other site 273123000845 11 probable transmembrane helices predicted by TMHMM2.0 273123000846 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 273123000847 Chain length determinant protein; Region: Wzz; cl15801 273123000848 2 probable transmembrane helices predicted by TMHMM2.0 273123000849 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 273123000850 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 273123000851 active site 273123000852 homodimer interface [polypeptide binding]; other site 273123000853 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 273123000854 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 273123000855 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 273123000856 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 273123000857 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 273123000858 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 273123000859 NAD binding site [chemical binding]; other site 273123000860 substrate binding site [chemical binding]; other site 273123000861 homodimer interface [polypeptide binding]; other site 273123000862 active site 273123000863 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 273123000864 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 273123000865 substrate binding site; other site 273123000866 tetramer interface; other site 273123000867 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 273123000868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273123000869 Coenzyme A binding pocket [chemical binding]; other site 273123000870 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 273123000871 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 273123000872 inhibitor-cofactor binding pocket; inhibition site 273123000873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123000874 catalytic residue [active] 273123000875 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 273123000876 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 273123000877 12 probable transmembrane helices predicted by TMHMM2.0 273123000878 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 273123000879 putative common antigen polymerase; Provisional; Region: PRK02975 273123000880 11 probable transmembrane helices predicted by TMHMM2.0 273123000881 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 273123000882 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 273123000883 putative transport protein YifK; Provisional; Region: PRK10746 273123000884 12 probable transmembrane helices predicted by TMHMM2.0 273123000885 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 273123000886 HemY protein N-terminus; Region: HemY_N; pfam07219 273123000887 2 probable transmembrane helices predicted by TMHMM2.0 273123000888 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 273123000889 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 273123000890 1 probable transmembrane helix predicted by TMHMM2.0 273123000891 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 273123000892 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 273123000893 active site 273123000894 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 273123000895 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 273123000896 domain interfaces; other site 273123000897 active site 273123000898 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 273123000899 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 273123000900 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 273123000901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 273123000902 MULE transposase domain; Region: MULE; pfam10551 273123000903 possible Pentapeptide repeats (8 copies) 273123000904 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 273123000905 putative iron binding site [ion binding]; other site 273123000906 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 273123000907 1 probable transmembrane helix predicted by TMHMM2.0 273123000908 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 273123000909 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 273123000910 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 273123000911 hypothetical protein; Provisional; Region: PRK10963 273123000912 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 273123000913 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 273123000914 active site 273123000915 Int/Topo IB signature motif; other site 273123000916 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 273123000917 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123000918 motif II; other site 273123000919 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 273123000920 Part of AAA domain; Region: AAA_19; pfam13245 273123000921 Family description; Region: UvrD_C_2; pfam13538 273123000922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 273123000923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 273123000924 Uncharacterized conserved protein [Function unknown]; Region: COG5441 273123000925 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 273123000926 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 273123000927 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 273123000928 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 273123000929 Cl binding site [ion binding]; other site 273123000930 oligomer interface [polypeptide binding]; other site 273123000931 2 probable transmembrane helices predicted by TMHMM2.0 273123000932 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 273123000933 EamA-like transporter family; Region: EamA; cl17759 273123000934 10 probable transmembrane helices predicted by TMHMM2.0 273123000935 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 273123000936 CoenzymeA binding site [chemical binding]; other site 273123000937 subunit interaction site [polypeptide binding]; other site 273123000938 PHB binding site; other site 273123000939 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 273123000940 substrate binding site [chemical binding]; other site 273123000941 dimerization interface [polypeptide binding]; other site 273123000942 active site 273123000943 calcium binding site [ion binding]; other site 273123000944 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 273123000945 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273123000946 ATP binding site [chemical binding]; other site 273123000947 putative Mg++ binding site [ion binding]; other site 273123000948 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123000949 nucleotide binding region [chemical binding]; other site 273123000950 ATP-binding site [chemical binding]; other site 273123000951 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 273123000952 HRDC domain; Region: HRDC; pfam00570 273123000953 threonine efflux system; Provisional; Region: PRK10229 273123000954 6 probable transmembrane helices predicted by TMHMM2.0 273123000955 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 273123000956 6 probable transmembrane helices predicted by TMHMM2.0 273123000957 lysophospholipase L2; Provisional; Region: PRK10749 273123000958 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 273123000959 putative hydrolase; Provisional; Region: PRK10976 273123000960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123000961 active site 273123000962 motif I; other site 273123000963 motif II; other site 273123000964 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 273123000965 Viral enhancin protein; Region: Enhancin; pfam03272 273123000966 Viral enhancin protein; Region: Enhancin; pfam03272 273123000967 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 273123000968 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 273123000969 active site 273123000970 catalytic site [active] 273123000971 metal binding site [ion binding]; metal-binding site 273123000972 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 273123000973 hydroxyglutarate oxidase; Provisional; Region: PRK11728 273123000974 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 273123000975 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 273123000976 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 273123000977 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 273123000978 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273123000979 Cysteine-rich domain; Region: CCG; pfam02754 273123000980 Cysteine-rich domain; Region: CCG; pfam02754 273123000981 hypothetical protein; Provisional; Region: PRK11615 273123000982 hypothetical protein; Provisional; Region: PRK11212 273123000983 6 probable transmembrane helices predicted by TMHMM2.0 273123000984 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 273123000985 CPxP motif; other site 273123000986 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 273123000987 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 273123000988 metal-binding site [ion binding] 273123000989 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273123000990 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 273123000991 6 probable transmembrane helices predicted by TMHMM2.0 273123000992 Predicted membrane protein [Function unknown]; Region: COG3714 273123000993 7 probable transmembrane helices predicted by TMHMM2.0 273123000994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4517 273123000995 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 273123000996 1 probable transmembrane helix predicted by TMHMM2.0 273123000997 hypothetical protein; Provisional; Region: PRK10910 273123000998 3 probable transmembrane helices predicted by TMHMM2.0 273123000999 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 273123001000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123001001 S-adenosylmethionine binding site [chemical binding]; other site 273123001002 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 273123001003 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 273123001004 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 273123001005 P loop; other site 273123001006 GTP binding site [chemical binding]; other site 273123001007 cell division protein FtsE; Provisional; Region: PRK10908 273123001008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123001009 Walker A/P-loop; other site 273123001010 ATP binding site [chemical binding]; other site 273123001011 Q-loop/lid; other site 273123001012 ABC transporter signature motif; other site 273123001013 Walker B; other site 273123001014 D-loop; other site 273123001015 H-loop/switch region; other site 273123001016 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 273123001017 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 273123001018 4 probable transmembrane helices predicted by TMHMM2.0 273123001019 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 273123001020 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273123001021 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273123001022 DNA binding residues [nucleotide binding] 273123001023 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 273123001024 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 273123001025 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 273123001026 dimerization interface [polypeptide binding]; other site 273123001027 ligand binding site [chemical binding]; other site 273123001028 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123001029 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 273123001030 TM-ABC transporter signature motif; other site 273123001031 8 probable transmembrane helices predicted by TMHMM2.0 273123001032 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 273123001033 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 273123001034 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 273123001035 TM-ABC transporter signature motif; other site 273123001036 11 probable transmembrane helices predicted by TMHMM2.0 273123001037 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 273123001038 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 273123001039 Walker A/P-loop; other site 273123001040 ATP binding site [chemical binding]; other site 273123001041 Q-loop/lid; other site 273123001042 ABC transporter signature motif; other site 273123001043 Walker B; other site 273123001044 D-loop; other site 273123001045 H-loop/switch region; other site 273123001046 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 273123001047 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 273123001048 Walker A/P-loop; other site 273123001049 ATP binding site [chemical binding]; other site 273123001050 Q-loop/lid; other site 273123001051 ABC transporter signature motif; other site 273123001052 Walker B; other site 273123001053 D-loop; other site 273123001054 H-loop/switch region; other site 273123001055 1 probable transmembrane helix predicted by TMHMM2.0 273123001056 putative fimbrial protein TcfA; Provisional; Region: PRK15308 273123001057 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 273123001058 putative fimbrial protein TcfA; Provisional; Region: PRK15308 273123001059 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 273123001060 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 273123001061 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 273123001062 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 273123001063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123001064 dimer interface [polypeptide binding]; other site 273123001065 conserved gate region; other site 273123001066 putative PBP binding loops; other site 273123001067 ABC-ATPase subunit interface; other site 273123001068 6 probable transmembrane helices predicted by TMHMM2.0 273123001069 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273123001070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123001071 dimer interface [polypeptide binding]; other site 273123001072 conserved gate region; other site 273123001073 putative PBP binding loops; other site 273123001074 ABC-ATPase subunit interface; other site 273123001075 7 probable transmembrane helices predicted by TMHMM2.0 273123001076 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 273123001077 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 273123001078 Walker A/P-loop; other site 273123001079 ATP binding site [chemical binding]; other site 273123001080 Q-loop/lid; other site 273123001081 ABC transporter signature motif; other site 273123001082 Walker B; other site 273123001083 D-loop; other site 273123001084 H-loop/switch region; other site 273123001085 TOBE domain; Region: TOBE_2; pfam08402 273123001086 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 273123001087 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 273123001088 putative active site [active] 273123001089 catalytic site [active] 273123001090 putative metal binding site [ion binding]; other site 273123001091 Predicted permeases [General function prediction only]; Region: COG0679 273123001092 10 probable transmembrane helices predicted by TMHMM2.0 273123001093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273123001094 non-specific DNA binding site [nucleotide binding]; other site 273123001095 salt bridge; other site 273123001096 sequence-specific DNA binding site [nucleotide binding]; other site 273123001097 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 273123001098 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 273123001099 10 probable transmembrane helices predicted by TMHMM2.0 273123001100 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 273123001101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123001102 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 273123001103 putative dimerization interface [polypeptide binding]; other site 273123001104 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 273123001105 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 273123001106 THF binding site; other site 273123001107 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 273123001108 substrate binding site [chemical binding]; other site 273123001109 THF binding site; other site 273123001110 zinc-binding site [ion binding]; other site 273123001111 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 273123001112 Ribosome-binding factor A; Region: RBFA; cl00542 273123001113 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 273123001114 uridine phosphorylase; Provisional; Region: PRK11178 273123001115 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 273123001116 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 273123001117 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 273123001118 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 273123001119 Carbon starvation protein CstA; Region: CstA; pfam02554 273123001120 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 273123001121 15 probable transmembrane helices predicted by TMHMM2.0 273123001122 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 273123001123 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 273123001124 4 probable transmembrane helices predicted by TMHMM2.0 273123001125 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 273123001126 RmuC family; Region: RmuC; pfam02646 273123001127 1 probable transmembrane helix predicted by TMHMM2.0 273123001128 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 273123001129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123001130 S-adenosylmethionine binding site [chemical binding]; other site 273123001131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 273123001132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 273123001133 SCP-2 sterol transfer family; Region: SCP2; pfam02036 273123001134 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 273123001135 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 273123001136 1 probable transmembrane helix predicted by TMHMM2.0 273123001137 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 273123001138 1 probable transmembrane helix predicted by TMHMM2.0 273123001139 sec-independent translocase; Provisional; Region: PRK01770 273123001140 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 273123001141 6 probable transmembrane helices predicted by TMHMM2.0 273123001142 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 273123001143 active site 273123001144 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 273123001145 dimer interface [polypeptide binding]; other site 273123001146 allosteric magnesium binding site [ion binding]; other site 273123001147 active site 273123001148 aspartate-rich active site metal binding site; other site 273123001149 Schiff base residues; other site 273123001150 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 273123001151 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 273123001152 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 273123001153 heterodimer interface [polypeptide binding]; other site 273123001154 homodimer interface [polypeptide binding]; other site 273123001155 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 273123001156 FMN reductase; Validated; Region: fre; PRK08051 273123001157 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 273123001158 FAD binding pocket [chemical binding]; other site 273123001159 FAD binding motif [chemical binding]; other site 273123001160 phosphate binding motif [ion binding]; other site 273123001161 beta-alpha-beta structure motif; other site 273123001162 NAD binding pocket [chemical binding]; other site 273123001163 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 273123001164 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 273123001165 dimer interface [polypeptide binding]; other site 273123001166 active site 273123001167 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 273123001168 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 273123001169 substrate binding site [chemical binding]; other site 273123001170 oxyanion hole (OAH) forming residues; other site 273123001171 trimer interface [polypeptide binding]; other site 273123001172 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 273123001173 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 273123001174 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 273123001175 proline dipeptidase; Provisional; Region: PRK13607 273123001176 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 273123001177 active site 273123001178 hypothetical protein; Provisional; Region: PRK11568 273123001179 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 273123001180 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 273123001181 potassium transporter; Provisional; Region: PRK10750 273123001182 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 273123001183 11 probable transmembrane helices predicted by TMHMM2.0 273123001184 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 273123001185 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 273123001186 FAD binding domain; Region: FAD_binding_4; pfam01565 273123001187 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 273123001188 Biotin operon repressor [Transcription]; Region: BirA; COG1654 273123001189 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 273123001190 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 273123001191 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 273123001192 pantothenate kinase; Provisional; Region: PRK05439 273123001193 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 273123001194 ATP-binding site [chemical binding]; other site 273123001195 CoA-binding site [chemical binding]; other site 273123001196 Mg2+-binding site [ion binding]; other site 273123001197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273123001198 Coenzyme A binding pocket [chemical binding]; other site 273123001199 elongation factor Tu; Reviewed; Region: PRK00049 273123001200 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 273123001201 G1 box; other site 273123001202 GEF interaction site [polypeptide binding]; other site 273123001203 GTP/Mg2+ binding site [chemical binding]; other site 273123001204 Switch I region; other site 273123001205 G2 box; other site 273123001206 G3 box; other site 273123001207 Switch II region; other site 273123001208 G4 box; other site 273123001209 G5 box; other site 273123001210 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 273123001211 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 273123001212 Antibiotic Binding Site [chemical binding]; other site 273123001213 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 273123001214 3 probable transmembrane helices predicted by TMHMM2.0 273123001215 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 273123001216 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 273123001217 putative homodimer interface [polypeptide binding]; other site 273123001218 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 273123001219 heterodimer interface [polypeptide binding]; other site 273123001220 homodimer interface [polypeptide binding]; other site 273123001221 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 273123001222 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 273123001223 23S rRNA interface [nucleotide binding]; other site 273123001224 L7/L12 interface [polypeptide binding]; other site 273123001225 putative thiostrepton binding site; other site 273123001226 L25 interface [polypeptide binding]; other site 273123001227 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 273123001228 mRNA/rRNA interface [nucleotide binding]; other site 273123001229 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 273123001230 23S rRNA interface [nucleotide binding]; other site 273123001231 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 273123001232 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 273123001233 core dimer interface [polypeptide binding]; other site 273123001234 peripheral dimer interface [polypeptide binding]; other site 273123001235 L10 interface [polypeptide binding]; other site 273123001236 L11 interface [polypeptide binding]; other site 273123001237 putative EF-Tu interaction site [polypeptide binding]; other site 273123001238 putative EF-G interaction site [polypeptide binding]; other site 273123001239 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 273123001240 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 273123001241 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 273123001242 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 273123001243 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 273123001244 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 273123001245 RPB3 interaction site [polypeptide binding]; other site 273123001246 RPB1 interaction site [polypeptide binding]; other site 273123001247 RPB11 interaction site [polypeptide binding]; other site 273123001248 RPB10 interaction site [polypeptide binding]; other site 273123001249 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 273123001250 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 273123001251 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 273123001252 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 273123001253 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 273123001254 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 273123001255 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 273123001256 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 273123001257 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 273123001258 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 273123001259 DNA binding site [nucleotide binding] 273123001260 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 273123001261 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 273123001262 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123001263 FeS/SAM binding site; other site 273123001264 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 273123001265 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 273123001266 ThiS interaction site; other site 273123001267 putative active site [active] 273123001268 tetramer interface [polypeptide binding]; other site 273123001269 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 273123001270 thiS-thiF/thiG interaction site; other site 273123001271 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 273123001272 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 273123001273 ATP binding site [chemical binding]; other site 273123001274 substrate interface [chemical binding]; other site 273123001275 1 probable transmembrane helix predicted by TMHMM2.0 273123001276 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 273123001277 thiamine phosphate binding site [chemical binding]; other site 273123001278 active site 273123001279 pyrophosphate binding site [ion binding]; other site 273123001280 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 273123001281 ThiC-associated domain; Region: ThiC-associated; pfam13667 273123001282 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 273123001283 similar to Yersinia pestis YPO3738 with a frameshift 273123001284 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 273123001285 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 273123001286 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 273123001287 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 273123001288 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 273123001289 putative NADH binding site [chemical binding]; other site 273123001290 putative active site [active] 273123001291 nudix motif; other site 273123001292 putative metal binding site [ion binding]; other site 273123001293 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 273123001294 substrate binding site [chemical binding]; other site 273123001295 active site 273123001296 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 273123001297 Active_site [active] 273123001298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 273123001299 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 273123001300 IHF dimer interface [polypeptide binding]; other site 273123001301 IHF - DNA interface [nucleotide binding]; other site 273123001302 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 273123001303 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 273123001304 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 273123001305 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 273123001306 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 273123001307 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 273123001308 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 273123001309 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 273123001310 purine monophosphate binding site [chemical binding]; other site 273123001311 dimer interface [polypeptide binding]; other site 273123001312 putative catalytic residues [active] 273123001313 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 273123001314 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 273123001315 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 273123001316 DNA-binding interface [nucleotide binding]; DNA binding site 273123001317 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 273123001318 HTH-like domain; Region: HTH_21; pfam13276 273123001319 Integrase core domain; Region: rve; pfam00665 273123001320 Integrase core domain; Region: rve_3; pfam13683 273123001322 transposase/IS protein; Provisional; Region: PRK09183 273123001323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123001324 Walker A motif; other site 273123001325 ATP binding site [chemical binding]; other site 273123001326 Walker B motif; other site 273123001327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 273123001328 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 273123001329 DNA-binding interface [nucleotide binding]; DNA binding site 273123001330 Integrase core domain; Region: rve; pfam00665 273123001331 Abhydrolase family; Region: Abhydrolase_7; pfam12715 273123001332 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 273123001333 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 273123001334 Na binding site [ion binding]; other site 273123001335 14 probable transmembrane helices predicted by TMHMM2.0 273123001336 Predicted membrane protein [Function unknown]; Region: COG3162 273123001337 2 probable transmembrane helices predicted by TMHMM2.0 273123001338 acetyl-CoA synthetase; Provisional; Region: PRK00174 273123001339 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 273123001340 active site 273123001341 CoA binding site [chemical binding]; other site 273123001342 acyl-activating enzyme (AAE) consensus motif; other site 273123001343 AMP binding site [chemical binding]; other site 273123001344 acetate binding site [chemical binding]; other site 273123001345 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 273123001346 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 273123001347 8 probable transmembrane helices predicted by TMHMM2.0 273123001348 two component system sensor kinase SsrB; Provisional; Region: PRK15369 273123001349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123001350 active site 273123001351 phosphorylation site [posttranslational modification] 273123001352 intermolecular recognition site; other site 273123001353 dimerization interface [polypeptide binding]; other site 273123001354 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123001355 DNA binding residues [nucleotide binding] 273123001356 dimerization interface [polypeptide binding]; other site 273123001357 two component system sensor kinase SsrA; Provisional; Region: PRK15347 273123001358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123001359 dimer interface [polypeptide binding]; other site 273123001360 phosphorylation site [posttranslational modification] 273123001361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123001362 ATP binding site [chemical binding]; other site 273123001363 Mg2+ binding site [ion binding]; other site 273123001364 G-X-G motif; other site 273123001365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123001366 active site 273123001367 phosphorylation site [posttranslational modification] 273123001368 intermolecular recognition site; other site 273123001369 dimerization interface [polypeptide binding]; other site 273123001370 Hpt domain; Region: Hpt; pfam01627 273123001371 3 probable transmembrane helices predicted by TMHMM2.0 273123001372 outer membrane secretin SsaC; Provisional; Region: PRK15346 273123001373 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 273123001374 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 273123001375 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 273123001376 1 probable transmembrane helix predicted by TMHMM2.0 273123001377 type III secretion system protein SsaD; Provisional; Region: PRK15367 273123001378 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 273123001379 1 probable transmembrane helix predicted by TMHMM2.0 273123001380 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 273123001381 Helix-turn-helix domain; Region: HTH_18; pfam12833 273123001382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123001383 Type III secretion needle MxiH like; Region: MxiH; cl09641 273123001384 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 273123001385 Type III secretion needle MxiH like; Region: MxiH; pfam09392 273123001386 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 273123001387 1 probable transmembrane helix predicted by TMHMM2.0 273123001388 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 273123001389 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 273123001390 type III secretion system protein SsaK; Provisional; Region: PRK15354 273123001391 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 273123001392 FHIPEP family; Region: FHIPEP; pfam00771 273123001393 7 probable transmembrane helices predicted by TMHMM2.0 273123001394 type III secretion system ATPase; Validated; Region: PRK06820 273123001395 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 273123001396 Walker A motif/ATP binding site; other site 273123001397 Walker B motif; other site 273123001398 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 273123001399 type III secretion system protein SsaQ; Validated; Region: PRK08035 273123001400 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 273123001401 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 273123001402 4 probable transmembrane helices predicted by TMHMM2.0 273123001403 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 273123001404 2 probable transmembrane helices predicted by TMHMM2.0 273123001405 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 273123001406 6 probable transmembrane helices predicted by TMHMM2.0 273123001407 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 273123001408 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 273123001409 4 probable transmembrane helices predicted by TMHMM2.0 273123001410 putative inner membrane protein; Provisional; Region: PRK11099 273123001411 Sulphur transport; Region: Sulf_transp; pfam04143 273123001412 10 probable transmembrane helices predicted by TMHMM2.0 273123001413 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 273123001414 CPxP motif; other site 273123001415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123001416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123001417 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 273123001418 putative effector binding pocket; other site 273123001419 dimerization interface [polypeptide binding]; other site 273123001420 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 273123001421 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 273123001422 12 probable transmembrane helices predicted by TMHMM2.0 273123001423 cystathionine beta-lyase; Provisional; Region: PRK09028 273123001424 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 273123001425 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123001426 catalytic residue [active] 273123001427 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 273123001428 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 273123001429 Walker A/P-loop; other site 273123001430 ATP binding site [chemical binding]; other site 273123001431 Q-loop/lid; other site 273123001432 ABC transporter signature motif; other site 273123001433 Walker B; other site 273123001434 D-loop; other site 273123001435 H-loop/switch region; other site 273123001436 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 273123001437 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123001438 ABC-ATPase subunit interface; other site 273123001439 dimer interface [polypeptide binding]; other site 273123001440 putative PBP binding regions; other site 273123001441 8 probable transmembrane helices predicted by TMHMM2.0 273123001442 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 273123001443 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 273123001444 putative hemin binding site; other site 273123001445 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 273123001446 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 273123001447 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 273123001448 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 273123001449 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 273123001450 N-terminal plug; other site 273123001451 ligand-binding site [chemical binding]; other site 273123001452 Hemin uptake protein hemP; Region: hemP; pfam10636 273123001453 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 273123001454 NADH(P)-binding; Region: NAD_binding_10; pfam13460 273123001455 NAD(P) binding site [chemical binding]; other site 273123001456 putative active site [active] 273123001457 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 273123001458 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 273123001459 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123001460 FeS/SAM binding site; other site 273123001461 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 273123001462 FAD binding site [chemical binding]; other site 273123001463 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 273123001464 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 273123001465 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 273123001466 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273123001467 active site 273123001468 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 273123001469 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 273123001470 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 273123001471 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 273123001472 putative metal binding site [ion binding]; other site 273123001473 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 273123001474 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 273123001475 putative metal binding site [ion binding]; other site 273123001476 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 273123001477 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 273123001478 putative metal binding site [ion binding]; other site 273123001479 tellurite resistance protein terB; Region: terB; cd07176 273123001480 putative metal binding site [ion binding]; other site 273123001481 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 273123001482 9 probable transmembrane helices predicted by TMHMM2.0 273123001483 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 273123001484 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 273123001485 putative metal binding site [ion binding]; other site 273123001486 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 273123001487 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 273123001488 putative metal binding site [ion binding]; other site 273123001489 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 273123001490 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 273123001491 PapC N-terminal domain; Region: PapC_N; pfam13954 273123001492 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 273123001493 PapC C-terminal domain; Region: PapC_C; pfam13953 273123001494 putative fimbrial chaperone protein; Provisional; Region: PRK09918 273123001495 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 273123001496 1 probable transmembrane helix predicted by TMHMM2.0 273123001497 similar to Yersinia pestis YPO0304 with a frameshift. 273123001498 hypothetical 273123001499 3 probable transmembrane helices predicted by TMHMM2.0 273123001500 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 273123001501 Berberine and berberine like; Region: BBE; pfam08031 273123001502 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 273123001503 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 273123001504 Interdomain contacts; other site 273123001505 Cytokine receptor motif; other site 273123001506 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 273123001507 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 273123001508 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 273123001509 Autotransporter beta-domain; Region: Autotransporter; smart00869 273123001510 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 273123001511 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 273123001512 UbiA prenyltransferase family; Region: UbiA; pfam01040 273123001513 7 probable transmembrane helices predicted by TMHMM2.0 273123001514 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 273123001515 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 273123001516 putative acyl-acceptor binding pocket; other site 273123001517 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 273123001518 2 probable transmembrane helices predicted by TMHMM2.0 273123001519 LexA repressor; Validated; Region: PRK00215 273123001520 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 273123001521 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 273123001522 Catalytic site [active] 273123001523 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 273123001524 metal binding site 2 [ion binding]; metal-binding site 273123001525 putative DNA binding helix; other site 273123001526 metal binding site 1 [ion binding]; metal-binding site 273123001527 dimer interface [polypeptide binding]; other site 273123001528 structural Zn2+ binding site [ion binding]; other site 273123001529 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 273123001530 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 273123001531 FMN binding site [chemical binding]; other site 273123001532 active site 273123001533 catalytic residues [active] 273123001534 substrate binding site [chemical binding]; other site 273123001535 phage shock protein G; Reviewed; Region: pspG; PRK09459 273123001536 2 probable transmembrane helices predicted by TMHMM2.0 273123001537 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 273123001538 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 273123001539 NADP binding site [chemical binding]; other site 273123001540 dimer interface [polypeptide binding]; other site 273123001541 replicative DNA helicase; Provisional; Region: PRK08006 273123001542 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 273123001543 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 273123001544 Walker A motif; other site 273123001545 ATP binding site [chemical binding]; other site 273123001546 Walker B motif; other site 273123001547 DNA binding loops [nucleotide binding] 273123001548 alanine racemase; Reviewed; Region: alr; PRK00053 273123001549 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 273123001550 active site 273123001551 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273123001552 substrate binding site [chemical binding]; other site 273123001553 catalytic residues [active] 273123001554 dimer interface [polypeptide binding]; other site 273123001555 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 273123001556 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123001557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123001558 homodimer interface [polypeptide binding]; other site 273123001559 catalytic residue [active] 273123001560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 273123001561 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 273123001562 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 273123001563 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 273123001564 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 273123001565 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 273123001566 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 273123001567 dimer interface [polypeptide binding]; other site 273123001568 ssDNA binding site [nucleotide binding]; other site 273123001569 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273123001570 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 273123001571 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 273123001572 lactaldehyde reductase; Region: lactal_redase; TIGR02638 273123001573 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 273123001574 dimer interface [polypeptide binding]; other site 273123001575 active site 273123001576 metal binding site [ion binding]; metal-binding site 273123001577 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 273123001578 intersubunit interface [polypeptide binding]; other site 273123001579 active site 273123001580 Zn2+ binding site [ion binding]; other site 273123001581 L-rhamnose isomerase; Provisional; Region: PRK01076 273123001582 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 273123001583 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 273123001584 N- and C-terminal domain interface [polypeptide binding]; other site 273123001585 active site 273123001586 putative catalytic site [active] 273123001587 metal binding site [ion binding]; metal-binding site 273123001588 ATP binding site [chemical binding]; other site 273123001589 rhamnulokinase; Provisional; Region: rhaB; PRK10640 273123001590 carbohydrate binding site [chemical binding]; other site 273123001591 transcriptional activator RhaS; Provisional; Region: PRK13503 273123001592 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 273123001593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123001594 transcriptional activator RhaR; Provisional; Region: PRK13501 273123001595 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 273123001596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123001597 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 273123001598 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 273123001599 10 probable transmembrane helices predicted by TMHMM2.0 273123001600 similar to Escherichia coli Z1562 unknown in IS1N (74.2% evalue=5.E-22); Escherichia coli Z1123 unknown in IS1N (74.2% evalue=5.E-22);possible transposase (similar to InsB 86% in S. dys) 273123001601 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 273123001602 Viral enhancin protein; Region: Enhancin; pfam03272 273123001603 Peptidase M60-like family; Region: M60-like; pfam13402 273123001604 hypothetical 273123001605 putative transcriptional regulator; Provisional; Region: PRK11640 273123001606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 273123001607 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 273123001608 4Fe-4S binding domain; Region: Fer4; pfam00037 273123001609 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273123001610 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273123001611 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 273123001612 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 273123001613 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 273123001614 [4Fe-4S] binding site [ion binding]; other site 273123001615 molybdopterin cofactor binding site; other site 273123001616 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 273123001617 molybdopterin cofactor binding site; other site 273123001618 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 273123001619 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 273123001620 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 273123001621 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 273123001622 DsbD alpha interface [polypeptide binding]; other site 273123001623 catalytic residues [active] 273123001624 8 probable transmembrane helices predicted by TMHMM2.0 273123001625 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 273123001626 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 273123001627 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 273123001628 11 probable transmembrane helices predicted by TMHMM2.0 273123001629 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 273123001630 Aspartase; Region: Aspartase; cd01357 273123001631 active sites [active] 273123001632 tetramer interface [polypeptide binding]; other site 273123001633 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 273123001634 3 probable transmembrane helices predicted by TMHMM2.0 273123001635 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 273123001636 oligomerisation interface [polypeptide binding]; other site 273123001637 mobile loop; other site 273123001638 roof hairpin; other site 273123001639 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 273123001640 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 273123001641 ring oligomerisation interface [polypeptide binding]; other site 273123001642 ATP/Mg binding site [chemical binding]; other site 273123001643 stacking interactions; other site 273123001644 hinge regions; other site 273123001645 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 273123001646 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 273123001647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123001648 FeS/SAM binding site; other site 273123001649 elongation factor P; Validated; Region: PRK00529 273123001650 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 273123001651 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 273123001652 RNA binding site [nucleotide binding]; other site 273123001653 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 273123001654 RNA binding site [nucleotide binding]; other site 273123001655 multidrug efflux system protein; Provisional; Region: PRK11431 273123001656 4 probable transmembrane helices predicted by TMHMM2.0 273123001657 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 273123001658 Iron-sulfur protein interface; other site 273123001659 proximal quinone binding site [chemical binding]; other site 273123001660 C-subunit interface; other site 273123001661 distal quinone binding site; other site 273123001662 3 probable transmembrane helices predicted by TMHMM2.0 273123001663 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 273123001664 D-subunit interface [polypeptide binding]; other site 273123001665 Iron-sulfur protein interface; other site 273123001666 proximal quinone binding site [chemical binding]; other site 273123001667 3 probable transmembrane helices predicted by TMHMM2.0 273123001668 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 273123001669 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 273123001670 catalytic loop [active] 273123001671 iron binding site [ion binding]; other site 273123001672 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 273123001673 L-aspartate oxidase; Provisional; Region: PRK06175 273123001674 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 273123001675 poxB regulator PoxA; Provisional; Region: PRK09350 273123001676 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 273123001677 motif 1; other site 273123001678 dimer interface [polypeptide binding]; other site 273123001679 active site 273123001680 motif 2; other site 273123001681 motif 3; other site 273123001682 putative mechanosensitive channel protein; Provisional; Region: PRK10929 273123001683 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 273123001684 Mechanosensitive ion channel; Region: MS_channel; pfam00924 273123001685 12 probable transmembrane helices predicted by TMHMM2.0 273123001686 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 273123001687 GTPase RsgA; Reviewed; Region: PRK12288 273123001688 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 273123001689 RNA binding site [nucleotide binding]; other site 273123001690 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 273123001691 GTPase/Zn-binding domain interface [polypeptide binding]; other site 273123001692 GTP/Mg2+ binding site [chemical binding]; other site 273123001693 G4 box; other site 273123001694 G5 box; other site 273123001695 G1 box; other site 273123001696 Switch I region; other site 273123001697 G2 box; other site 273123001698 G3 box; other site 273123001699 Switch II region; other site 273123001700 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 273123001701 catalytic site [active] 273123001702 putative active site [active] 273123001703 putative substrate binding site [chemical binding]; other site 273123001704 dimer interface [polypeptide binding]; other site 273123001705 epoxyqueuosine reductase; Region: TIGR00276 273123001706 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 273123001707 putative carbohydrate kinase; Provisional; Region: PRK10565 273123001708 Uncharacterized conserved protein [Function unknown]; Region: COG0062 273123001709 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 273123001710 putative substrate binding site [chemical binding]; other site 273123001711 putative ATP binding site [chemical binding]; other site 273123001712 ADP-binding protein; Provisional; Region: PRK10646 273123001713 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 273123001714 AMIN domain; Region: AMIN; pfam11741 273123001715 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 273123001716 active site 273123001717 metal binding site [ion binding]; metal-binding site 273123001718 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 273123001719 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273123001720 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 273123001721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273123001722 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 273123001723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123001724 ATP binding site [chemical binding]; other site 273123001725 Mg2+ binding site [ion binding]; other site 273123001726 G-X-G motif; other site 273123001727 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 273123001728 ATP binding site [chemical binding]; other site 273123001729 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 273123001730 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 273123001731 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 273123001732 bacterial Hfq-like; Region: Hfq; cd01716 273123001733 hexamer interface [polypeptide binding]; other site 273123001734 Sm1 motif; other site 273123001735 RNA binding site [nucleotide binding]; other site 273123001736 Sm2 motif; other site 273123001737 GTPase HflX; Provisional; Region: PRK11058 273123001738 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 273123001739 HflX GTPase family; Region: HflX; cd01878 273123001740 G1 box; other site 273123001741 GTP/Mg2+ binding site [chemical binding]; other site 273123001742 Switch I region; other site 273123001743 G2 box; other site 273123001744 G3 box; other site 273123001745 Switch II region; other site 273123001746 G4 box; other site 273123001747 G5 box; other site 273123001748 FtsH protease regulator HflK; Provisional; Region: PRK10930 273123001749 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 273123001750 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 273123001751 1 probable transmembrane helix predicted by TMHMM2.0 273123001752 FtsH protease regulator HflC; Provisional; Region: PRK11029 273123001753 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 273123001754 1 probable transmembrane helix predicted by TMHMM2.0 273123001755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 273123001756 2 probable transmembrane helices predicted by TMHMM2.0 273123001757 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 273123001758 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 273123001759 GDP-binding site [chemical binding]; other site 273123001760 ACT binding site; other site 273123001761 IMP binding site; other site 273123001762 transcriptional repressor NsrR; Provisional; Region: PRK11014 273123001763 Rrf2 family protein; Region: rrf2_super; TIGR00738 273123001764 exoribonuclease R; Provisional; Region: PRK11642 273123001765 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 273123001766 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 273123001767 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 273123001768 RNB domain; Region: RNB; pfam00773 273123001769 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 273123001770 RNA binding site [nucleotide binding]; other site 273123001771 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 273123001772 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 273123001773 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 273123001774 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 273123001775 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 273123001776 active site 273123001777 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 273123001778 2 probable transmembrane helices predicted by TMHMM2.0 273123001779 esterase; Provisional; Region: PRK10566 273123001780 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 273123001781 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 273123001782 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 273123001783 dimer interface [polypeptide binding]; other site 273123001784 ssDNA binding site [nucleotide binding]; other site 273123001785 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273123001786 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 273123001787 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 273123001788 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 273123001789 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 273123001790 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 273123001791 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 273123001792 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 273123001793 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 273123001794 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 273123001795 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 273123001796 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 273123001797 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 273123001798 Hemerythrin-like domain; Region: Hr-like; cd12108 273123001799 Fe binding site [ion binding]; other site 273123001800 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 273123001801 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 273123001802 active site 273123001803 metal binding site [ion binding]; metal-binding site 273123001804 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 273123001805 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 273123001806 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 273123001807 active site 273123001808 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 273123001809 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 273123001810 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 273123001811 Domain of unknown function DUF21; Region: DUF21; pfam01595 273123001812 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 273123001813 Transporter associated domain; Region: CorC_HlyC; smart01091 273123001814 4 probable transmembrane helices predicted by TMHMM2.0 273123001815 methionine sulfoxide reductase A; Provisional; Region: PRK00058 273123001816 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 273123001817 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 273123001818 Surface antigen; Region: Bac_surface_Ag; pfam01103 273123001819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 273123001820 Family of unknown function (DUF490); Region: DUF490; pfam04357 273123001821 1 probable transmembrane helix predicted by TMHMM2.0 273123001822 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 273123001823 putative active site pocket [active] 273123001824 dimerization interface [polypeptide binding]; other site 273123001825 putative catalytic residue [active] 273123001826 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 273123001827 dimer interface [polypeptide binding]; other site 273123001828 substrate binding site [chemical binding]; other site 273123001829 metal binding sites [ion binding]; metal-binding site 273123001830 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 273123001831 AMP binding site [chemical binding]; other site 273123001832 metal binding site [ion binding]; metal-binding site 273123001833 active site 273123001834 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 273123001835 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 273123001836 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 273123001837 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273123001838 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 273123001839 arginine repressor; Provisional; Region: PRK05066 273123001840 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 273123001841 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 273123001842 malate dehydrogenase; Provisional; Region: PRK05086 273123001843 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 273123001844 NAD binding site [chemical binding]; other site 273123001845 dimerization interface [polypeptide binding]; other site 273123001846 Substrate binding site [chemical binding]; other site 273123001847 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 273123001848 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 273123001849 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 273123001850 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 273123001851 substrate binding pocket [chemical binding]; other site 273123001852 chain length determination region; other site 273123001853 substrate-Mg2+ binding site; other site 273123001854 catalytic residues [active] 273123001855 aspartate-rich region 1; other site 273123001856 active site lid residues [active] 273123001857 aspartate-rich region 2; other site 273123001858 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 273123001859 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 273123001860 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 273123001861 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 273123001862 EamA-like transporter family; Region: EamA; pfam00892 273123001863 10 probable transmembrane helices predicted by TMHMM2.0 273123001864 GTPase CgtA; Reviewed; Region: obgE; PRK12298 273123001865 GTP1/OBG; Region: GTP1_OBG; pfam01018 273123001866 Obg GTPase; Region: Obg; cd01898 273123001867 G1 box; other site 273123001868 GTP/Mg2+ binding site [chemical binding]; other site 273123001869 Switch I region; other site 273123001870 G2 box; other site 273123001871 G3 box; other site 273123001872 Switch II region; other site 273123001873 G4 box; other site 273123001874 G5 box; other site 273123001875 sensor protein BasS/PmrB; Provisional; Region: PRK10755 273123001876 HAMP domain; Region: HAMP; pfam00672 273123001877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123001878 dimer interface [polypeptide binding]; other site 273123001879 phosphorylation site [posttranslational modification] 273123001880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123001881 ATP binding site [chemical binding]; other site 273123001882 Mg2+ binding site [ion binding]; other site 273123001883 G-X-G motif; other site 273123001884 2 probable transmembrane helices predicted by TMHMM2.0 273123001885 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 273123001886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123001887 active site 273123001888 phosphorylation site [posttranslational modification] 273123001889 intermolecular recognition site; other site 273123001890 dimerization interface [polypeptide binding]; other site 273123001891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123001892 DNA binding site [nucleotide binding] 273123001893 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 273123001894 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 273123001895 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 273123001896 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 273123001897 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 273123001898 RNA-binding protein YhbY; Provisional; Region: PRK10343 273123001899 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 273123001900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123001901 S-adenosylmethionine binding site [chemical binding]; other site 273123001902 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 273123001903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123001904 Walker A motif; other site 273123001905 ATP binding site [chemical binding]; other site 273123001906 Walker B motif; other site 273123001907 arginine finger; other site 273123001908 Peptidase family M41; Region: Peptidase_M41; pfam01434 273123001909 2 probable transmembrane helices predicted by TMHMM2.0 273123001910 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 273123001911 dihydropteroate synthase; Region: DHPS; TIGR01496 273123001912 substrate binding pocket [chemical binding]; other site 273123001913 dimer interface [polypeptide binding]; other site 273123001914 inhibitor binding site; inhibition site 273123001915 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 273123001916 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 273123001917 active site 273123001918 substrate binding site [chemical binding]; other site 273123001919 metal binding site [ion binding]; metal-binding site 273123001920 Preprotein translocase SecG subunit; Region: SecG; pfam03840 273123001921 2 probable transmembrane helices predicted by TMHMM2.0 273123001922 ribosome maturation protein RimP; Reviewed; Region: PRK00092 273123001923 Sm and related proteins; Region: Sm_like; cl00259 273123001924 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 273123001925 putative oligomer interface [polypeptide binding]; other site 273123001926 putative RNA binding site [nucleotide binding]; other site 273123001927 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 273123001928 NusA N-terminal domain; Region: NusA_N; pfam08529 273123001929 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 273123001930 RNA binding site [nucleotide binding]; other site 273123001931 homodimer interface [polypeptide binding]; other site 273123001932 NusA-like KH domain; Region: KH_5; pfam13184 273123001933 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 273123001934 G-X-X-G motif; other site 273123001935 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 273123001936 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 273123001937 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 273123001938 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 273123001939 translation initiation factor IF-2; Validated; Region: infB; PRK05306 273123001940 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 273123001941 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 273123001942 G1 box; other site 273123001943 putative GEF interaction site [polypeptide binding]; other site 273123001944 GTP/Mg2+ binding site [chemical binding]; other site 273123001945 Switch I region; other site 273123001946 G2 box; other site 273123001947 G3 box; other site 273123001948 Switch II region; other site 273123001949 G4 box; other site 273123001950 G5 box; other site 273123001951 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 273123001952 Translation-initiation factor 2; Region: IF-2; pfam11987 273123001953 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 273123001954 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 273123001955 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 273123001956 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 273123001957 RNA binding site [nucleotide binding]; other site 273123001958 active site 273123001959 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 273123001960 S15 5'UTR alternatively forms hairpins or a pseudoknot that regulates S15 translation 273123001961 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 273123001962 16S/18S rRNA binding site [nucleotide binding]; other site 273123001963 S13e-L30e interaction site [polypeptide binding]; other site 273123001964 25S rRNA binding site [nucleotide binding]; other site 273123001965 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 273123001966 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 273123001967 RNase E interface [polypeptide binding]; other site 273123001968 trimer interface [polypeptide binding]; other site 273123001969 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 273123001970 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 273123001971 RNase E interface [polypeptide binding]; other site 273123001972 trimer interface [polypeptide binding]; other site 273123001973 active site 273123001974 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 273123001975 putative nucleic acid binding region [nucleotide binding]; other site 273123001976 G-X-X-G motif; other site 273123001977 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 273123001978 RNA binding site [nucleotide binding]; other site 273123001979 domain interface; other site 273123001980 lipoprotein NlpI; Provisional; Region: PRK11189 273123001981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273123001982 binding surface 273123001983 TPR motif; other site 273123001984 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 273123001985 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 273123001986 ATP binding site [chemical binding]; other site 273123001987 Mg++ binding site [ion binding]; other site 273123001988 motif III; other site 273123001989 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123001990 nucleotide binding region [chemical binding]; other site 273123001991 ATP-binding site [chemical binding]; other site 273123001992 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 273123001993 putative RNA binding site [nucleotide binding]; other site 273123001994 Cold shock protein DEAD box A; Region: DEADboxA; pfam12343 273123001995 1 probable transmembrane helix predicted by TMHMM2.0 273123001996 Phage-related protein [Function unknown]; Region: COG4679 273123001997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273123001998 non-specific DNA binding site [nucleotide binding]; other site 273123001999 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 273123002000 salt bridge; other site 273123002001 sequence-specific DNA binding site [nucleotide binding]; other site 273123002002 hypothetical protein; Provisional; Region: PRK10508 273123002003 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 273123002004 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 273123002005 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 273123002006 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 273123002007 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123002008 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123002009 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 273123002010 Protein export membrane protein; Region: SecD_SecF; cl14618 273123002011 12 probable transmembrane helices predicted by TMHMM2.0 273123002012 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 273123002013 putative protease; Provisional; Region: PRK15447 273123002014 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 273123002015 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 273123002016 Peptidase family U32; Region: Peptidase_U32; pfam01136 273123002017 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 273123002018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273123002019 Coenzyme A binding pocket [chemical binding]; other site 273123002020 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 273123002021 GIY-YIG motif/motif A; other site 273123002022 putative active site [active] 273123002023 putative metal binding site [ion binding]; other site 273123002024 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 273123002025 Alginate lyase; Region: Alginate_lyase; pfam05426 273123002026 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 273123002027 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 273123002028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 273123002029 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 273123002030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123002031 dimer interface [polypeptide binding]; other site 273123002032 putative PBP binding loops; other site 273123002033 ABC-ATPase subunit interface; other site 273123002034 6 probable transmembrane helices predicted by TMHMM2.0 273123002035 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273123002036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123002037 dimer interface [polypeptide binding]; other site 273123002038 conserved gate region; other site 273123002039 putative PBP binding loops; other site 273123002040 ABC-ATPase subunit interface; other site 273123002041 6 probable transmembrane helices predicted by TMHMM2.0 273123002042 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 273123002043 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 273123002044 Walker A/P-loop; other site 273123002045 ATP binding site [chemical binding]; other site 273123002046 Q-loop/lid; other site 273123002047 ABC transporter signature motif; other site 273123002048 Walker B; other site 273123002049 D-loop; other site 273123002050 H-loop/switch region; other site 273123002051 TOBE domain; Region: TOBE_2; pfam08402 273123002052 Alginate lyase; Region: Alginate_lyase; pfam05426 273123002053 hypothetical protein; Provisional; Region: PRK03467 273123002054 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 273123002055 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 273123002056 NAD binding site [chemical binding]; other site 273123002057 active site 273123002058 putative hydrolase; Provisional; Region: PRK02113 273123002059 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 273123002060 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 273123002061 Guanylate kinase; Region: Guanylate_kin; pfam00625 273123002062 active site 273123002063 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 273123002064 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 273123002065 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 273123002066 active site 273123002067 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 273123002068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123002069 Walker A/P-loop; other site 273123002070 ATP binding site [chemical binding]; other site 273123002071 Q-loop/lid; other site 273123002072 ABC transporter signature motif; other site 273123002073 Walker B; other site 273123002074 D-loop; other site 273123002075 H-loop/switch region; other site 273123002076 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 273123002077 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123002078 Walker A/P-loop; other site 273123002079 ATP binding site [chemical binding]; other site 273123002080 Q-loop/lid; other site 273123002081 ABC transporter signature motif; other site 273123002082 Walker B; other site 273123002083 D-loop; other site 273123002084 H-loop/switch region; other site 273123002085 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273123002086 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 273123002087 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 273123002088 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 273123002089 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnG; COG3624 273123002090 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 273123002091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123002092 DNA-binding site [nucleotide binding]; DNA binding site 273123002093 UTRA domain; Region: UTRA; pfam07702 273123002094 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 273123002095 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 273123002096 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 273123002097 ATP cone domain; Region: ATP-cone; pfam03477 273123002098 Class III ribonucleotide reductase; Region: RNR_III; cd01675 273123002099 effector binding site; other site 273123002100 active site 273123002101 Zn binding site [ion binding]; other site 273123002102 glycine loop; other site 273123002103 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 273123002104 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123002105 Walker A/P-loop; other site 273123002106 ATP binding site [chemical binding]; other site 273123002107 Q-loop/lid; other site 273123002108 ABC transporter signature motif; other site 273123002109 Walker B; other site 273123002110 D-loop; other site 273123002111 H-loop/switch region; other site 273123002112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123002113 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 273123002114 Walker A/P-loop; other site 273123002115 ATP binding site [chemical binding]; other site 273123002116 Q-loop/lid; other site 273123002117 ABC transporter signature motif; other site 273123002118 Walker B; other site 273123002119 D-loop; other site 273123002120 H-loop/switch region; other site 273123002121 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 273123002122 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 273123002123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123002124 dimer interface [polypeptide binding]; other site 273123002125 conserved gate region; other site 273123002126 ABC-ATPase subunit interface; other site 273123002127 5 probable transmembrane helices predicted by TMHMM2.0 273123002128 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273123002129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123002130 dimer interface [polypeptide binding]; other site 273123002131 conserved gate region; other site 273123002132 putative PBP binding loops; other site 273123002133 ABC-ATPase subunit interface; other site 273123002134 6 probable transmembrane helices predicted by TMHMM2.0 273123002135 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 273123002136 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 273123002137 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 273123002138 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 273123002139 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 273123002140 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 273123002141 RNase E inhibitor protein; Provisional; Region: PRK11191 273123002142 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 273123002143 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 273123002144 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 273123002145 HIGH motif; other site 273123002146 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 273123002147 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 273123002148 active site 273123002149 KMSKS motif; other site 273123002150 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 273123002151 tRNA binding surface [nucleotide binding]; other site 273123002152 anticodon binding site; other site 273123002153 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 273123002154 DNA polymerase III subunit chi; Validated; Region: PRK05728 273123002155 multifunctional aminopeptidase A; Provisional; Region: PRK00913 273123002156 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 273123002157 interface (dimer of trimers) [polypeptide binding]; other site 273123002158 Substrate-binding/catalytic site; other site 273123002159 Zn-binding sites [ion binding]; other site 273123002160 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 273123002161 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 273123002162 6 probable transmembrane helices predicted by TMHMM2.0 273123002163 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 273123002164 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 273123002165 6 probable transmembrane helices predicted by TMHMM2.0 273123002166 similar to Yersinia pestis YPO3438 intB; integrase (98.7% evalue=0); Escherichia coli b4271 intB; prophage p4 integrase (int(P4)) (79.1% evalue=1.E-169) with a stop codon.;integrase pseudogene 273123002167 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 273123002168 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 273123002169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273123002170 ATP binding site [chemical binding]; other site 273123002171 putative Mg++ binding site [ion binding]; other site 273123002172 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cl07672 273123002173 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 273123002174 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 273123002175 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 273123002176 HsdM N-terminal domain; Region: HsdM_N; pfam12161 273123002177 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 273123002178 Methyltransferase domain; Region: Methyltransf_26; pfam13659 273123002179 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 273123002180 1 probable transmembrane helix predicted by TMHMM2.0 273123002181 Predicted membrane protein [Function unknown]; Region: COG4269 273123002182 8 probable transmembrane helices predicted by TMHMM2.0 273123002183 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 273123002184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123002185 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 273123002186 active site 273123002187 P-loop; other site 273123002188 phosphorylation site [posttranslational modification] 273123002189 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 273123002190 active site 273123002191 P-loop; other site 273123002192 phosphorylation site [posttranslational modification] 273123002193 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 273123002194 8 probable transmembrane helices predicted by TMHMM2.0 273123002195 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 273123002196 dimerization domain swap beta strand [polypeptide binding]; other site 273123002197 regulatory protein interface [polypeptide binding]; other site 273123002198 active site 273123002199 regulatory phosphorylation site [posttranslational modification]; other site 273123002200 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 273123002201 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 273123002202 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 273123002203 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 273123002204 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273123002205 active site 273123002206 phosphorylation site [posttranslational modification] 273123002207 hypothetical protein; Provisional; Region: PRK11667 273123002208 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 273123002209 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 273123002210 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 273123002211 putative active site; other site 273123002212 catalytic residue [active] 273123002213 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 273123002214 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 273123002215 ligand binding site [chemical binding]; other site 273123002216 1 probable transmembrane helix predicted by TMHMM2.0 273123002217 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123002218 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123002219 TM-ABC transporter signature motif; other site 273123002220 9 probable transmembrane helices predicted by TMHMM2.0 273123002221 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123002222 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123002223 TM-ABC transporter signature motif; other site 273123002224 9 probable transmembrane helices predicted by TMHMM2.0 273123002225 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 273123002226 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123002227 Walker A/P-loop; other site 273123002228 ATP binding site [chemical binding]; other site 273123002229 Q-loop/lid; other site 273123002230 ABC transporter signature motif; other site 273123002231 Walker B; other site 273123002232 D-loop; other site 273123002233 H-loop/switch region; other site 273123002234 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123002235 transcriptional regulator LsrR; Provisional; Region: PRK15418 273123002236 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 273123002237 non-specific DNA interactions [nucleotide binding]; other site 273123002238 DNA binding site [nucleotide binding] 273123002239 sequence specific DNA binding site [nucleotide binding]; other site 273123002240 putative cAMP binding site [chemical binding]; other site 273123002241 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 273123002242 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 273123002243 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 273123002244 putative N- and C-terminal domain interface [polypeptide binding]; other site 273123002245 putative active site [active] 273123002246 putative MgATP binding site [chemical binding]; other site 273123002247 catalytic site [active] 273123002248 metal binding site [ion binding]; metal-binding site 273123002249 putative carbohydrate binding site [chemical binding]; other site 273123002250 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 273123002251 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 273123002252 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 273123002253 putative active site [active] 273123002254 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 273123002255 O-Antigen ligase; Region: Wzy_C; pfam04932 273123002256 10 probable transmembrane helices predicted by TMHMM2.0 273123002257 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 273123002258 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 273123002259 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123002260 catalytic residue [active] 273123002261 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 273123002262 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 273123002263 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 273123002264 Ubiquitin-like proteins; Region: UBQ; cl00155 273123002265 charged pocket; other site 273123002266 hydrophobic patch; other site 273123002267 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 273123002268 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 273123002269 ATP binding site [chemical binding]; other site 273123002270 substrate interface [chemical binding]; other site 273123002271 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 273123002272 active site residue [active] 273123002273 1 probable transmembrane helix predicted by TMHMM2.0 273123002274 DDE superfamily endonuclease; Region: DDE_3; pfam13358 273123002275 1 probable transmembrane helix predicted by TMHMM2.0 273123002276 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 273123002277 2 probable transmembrane helices predicted by TMHMM2.0 273123002278 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 273123002279 Peptidase family M23; Region: Peptidase_M23; pfam01551 273123002280 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123002281 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 273123002282 12 probable transmembrane helices predicted by TMHMM2.0 273123002283 Pectinesterase; Region: Pectinesterase; pfam01095 273123002284 putative pectinesterase; Region: PLN02432; cl01911 273123002285 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 273123002286 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 273123002287 metal binding site [ion binding]; metal-binding site 273123002288 active site 273123002289 I-site; other site 273123002290 5 probable transmembrane helices predicted by TMHMM2.0 273123002291 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 273123002292 3 probable transmembrane helices predicted by TMHMM2.0 273123002293 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 273123002294 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 273123002295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123002296 S-adenosylmethionine binding site [chemical binding]; other site 273123002297 DNA polymerase III subunit psi; Validated; Region: PRK06856 273123002298 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 273123002299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273123002300 Coenzyme A binding pocket [chemical binding]; other site 273123002301 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 273123002302 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 273123002303 G1 box; other site 273123002304 putative GEF interaction site [polypeptide binding]; other site 273123002305 GTP/Mg2+ binding site [chemical binding]; other site 273123002306 Switch I region; other site 273123002307 G2 box; other site 273123002308 G3 box; other site 273123002309 Switch II region; other site 273123002310 G4 box; other site 273123002311 G5 box; other site 273123002312 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 273123002313 periplasmic protein; Provisional; Region: PRK10568 273123002314 BON domain; Region: BON; pfam04972 273123002315 BON domain; Region: BON; pfam04972 273123002316 2 probable transmembrane helices predicted by TMHMM2.0 273123002317 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 273123002318 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 273123002319 active site 273123002320 nucleophile elbow; other site 273123002321 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 273123002322 active site 273123002323 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 273123002324 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 273123002325 Nucleoside recognition; Region: Gate; pfam07670 273123002326 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 273123002327 9 probable transmembrane helices predicted by TMHMM2.0 273123002328 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 273123002329 intersubunit interface [polypeptide binding]; other site 273123002330 active site 273123002331 catalytic residue [active] 273123002332 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 273123002333 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 273123002334 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 273123002335 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 273123002336 phosphopentomutase; Provisional; Region: PRK05362 273123002337 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 273123002338 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 273123002339 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 273123002340 hypothetical protein; Provisional; Region: PRK11246 273123002341 2 probable transmembrane helices predicted by TMHMM2.0 273123002342 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 273123002343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123002344 motif II; other site 273123002345 DNA repair protein RadA; Provisional; Region: PRK11823 273123002346 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 273123002347 Walker A motif/ATP binding site; other site 273123002348 ATP binding site [chemical binding]; other site 273123002349 Walker B motif; other site 273123002350 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 273123002351 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273123002352 non-specific DNA binding site [nucleotide binding]; other site 273123002353 salt bridge; other site 273123002354 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 273123002355 sequence-specific DNA binding site [nucleotide binding]; other site 273123002356 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 273123002357 active site 273123002358 nucleotide binding site [chemical binding]; other site 273123002359 HIGH motif; other site 273123002360 KMSKS motif; other site 273123002361 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 273123002362 Fic family protein [Function unknown]; Region: COG3177 273123002363 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 273123002364 Fic/DOC family; Region: Fic; pfam02661 273123002365 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 273123002366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123002367 Walker A/P-loop; other site 273123002368 ATP binding site [chemical binding]; other site 273123002369 Q-loop/lid; other site 273123002370 ABC transporter signature motif; other site 273123002371 Walker B; other site 273123002372 D-loop; other site 273123002373 H-loop/switch region; other site 273123002374 ABC transporter; Region: ABC_tran_2; pfam12848 273123002375 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273123002376 putative outer membrane lipoprotein; Provisional; Region: PRK09967 273123002377 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 273123002378 ligand binding site [chemical binding]; other site 273123002379 1 probable transmembrane helix predicted by TMHMM2.0 273123002380 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 273123002381 HAMP domain; Region: HAMP; pfam00672 273123002382 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 273123002383 metal binding site [ion binding]; metal-binding site 273123002384 active site 273123002385 I-site; other site 273123002386 2 probable transmembrane helices predicted by TMHMM2.0 273123002387 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 273123002388 1 probable transmembrane helix predicted by TMHMM2.0 273123002389 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 273123002390 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 273123002391 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273123002392 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 273123002393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123002394 motif II; other site 273123002395 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 273123002396 10 probable transmembrane helices predicted by TMHMM2.0 273123002397 lytic murein transglycosylase; Provisional; Region: PRK11619 273123002398 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 273123002399 N-acetyl-D-glucosamine binding site [chemical binding]; other site 273123002400 catalytic residue [active] 273123002401 Trp operon repressor; Provisional; Region: PRK01381 273123002402 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 273123002403 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 273123002404 catalytic core [active] 273123002405 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 273123002406 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123002407 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 273123002408 hypothetical protein; Provisional; Region: PRK10756 273123002409 CreA protein; Region: CreA; pfam05981 273123002410 two-component response regulator; Provisional; Region: PRK11173 273123002411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123002412 active site 273123002413 phosphorylation site [posttranslational modification] 273123002414 intermolecular recognition site; other site 273123002415 dimerization interface [polypeptide binding]; other site 273123002416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123002417 DNA binding site [nucleotide binding] 273123002418 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 273123002419 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 273123002420 putative catalytic residues [active] 273123002421 putative nucleotide binding site [chemical binding]; other site 273123002422 putative aspartate binding site [chemical binding]; other site 273123002423 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 273123002424 dimer interface [polypeptide binding]; other site 273123002425 putative threonine allosteric regulatory site; other site 273123002426 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 273123002427 putative threonine allosteric regulatory site; other site 273123002428 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 273123002429 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 273123002430 homoserine kinase; Provisional; Region: PRK01212 273123002431 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 273123002432 threonine synthase; Validated; Region: PRK09225 273123002433 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 273123002434 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123002435 catalytic residue [active] 273123002436 hypothetical protein; Validated; Region: PRK02101 273123002437 transaldolase-like protein; Provisional; Region: PTZ00411 273123002438 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 273123002439 active site 273123002440 dimer interface [polypeptide binding]; other site 273123002441 catalytic residue [active] 273123002442 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 273123002443 MPT binding site; other site 273123002444 trimer interface [polypeptide binding]; other site 273123002445 metabolite-proton symporter; Region: 2A0106; TIGR00883 273123002446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123002447 putative substrate translocation pore; other site 273123002448 12 probable transmembrane helices predicted by TMHMM2.0 273123002449 Beta/Gamma crystallin; Region: Crystall; cl02528 273123002450 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 273123002451 hypothetical protein; Provisional; Region: PRK10659 273123002452 6 probable transmembrane helices predicted by TMHMM2.0 273123002453 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 273123002454 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 273123002455 nucleotide binding site [chemical binding]; other site 273123002456 chaperone protein DnaJ; Provisional; Region: PRK10767 273123002457 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 273123002458 HSP70 interaction site [polypeptide binding]; other site 273123002459 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 273123002460 substrate binding site [polypeptide binding]; other site 273123002461 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 273123002462 Zn binding sites [ion binding]; other site 273123002463 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 273123002464 dimer interface [polypeptide binding]; other site 273123002465 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 273123002466 10 probable transmembrane helices predicted by TMHMM2.0 273123002467 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 273123002468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123002469 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 273123002470 putative dimerization interface [polypeptide binding]; other site 273123002471 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 273123002472 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 273123002473 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 273123002474 active site 273123002475 Riboflavin kinase; Region: Flavokinase; smart00904 273123002476 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 273123002477 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 273123002478 active site 273123002479 HIGH motif; other site 273123002480 nucleotide binding site [chemical binding]; other site 273123002481 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 273123002482 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 273123002483 active site 273123002484 KMSKS motif; other site 273123002485 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 273123002486 tRNA binding surface [nucleotide binding]; other site 273123002487 anticodon binding site; other site 273123002488 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 273123002489 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 273123002490 lipoprotein signal peptidase; Provisional; Region: PRK14787 273123002491 4 probable transmembrane helices predicted by TMHMM2.0 273123002492 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 273123002493 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 273123002494 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 273123002495 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 273123002496 Transposase IS200 like; Region: Y1_Tnp; pfam01797 273123002497 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 273123002498 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 273123002499 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 273123002500 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 273123002501 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 273123002502 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 273123002503 catalytic site [active] 273123002504 subunit interface [polypeptide binding]; other site 273123002505 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 273123002506 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 273123002507 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 273123002508 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 273123002509 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 273123002510 ATP-grasp domain; Region: ATP-grasp_4; cl17255 273123002511 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 273123002512 IMP binding site; other site 273123002513 dimer interface [polypeptide binding]; other site 273123002514 interdomain contacts; other site 273123002515 partial ornithine binding site; other site 273123002516 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 273123002517 5 probable transmembrane helices predicted by TMHMM2.0 273123002518 Uncharacterized conserved protein [Function unknown]; Region: COG2966 273123002519 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 273123002520 4 probable transmembrane helices predicted by TMHMM2.0 273123002521 hypothetical protein; Provisional; Region: PRK09917 273123002522 4 probable transmembrane helices predicted by TMHMM2.0 273123002523 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 273123002524 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 273123002525 folate binding site [chemical binding]; other site 273123002526 NADP+ binding site [chemical binding]; other site 273123002527 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 273123002528 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 273123002529 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 273123002530 active site 273123002531 metal binding site [ion binding]; metal-binding site 273123002532 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 273123002533 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 273123002534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123002535 S-adenosylmethionine binding site [chemical binding]; other site 273123002536 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 273123002537 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 273123002538 SurA N-terminal domain; Region: SurA_N; pfam09312 273123002539 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 273123002540 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 273123002541 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 273123002542 OstA-like protein; Region: OstA; pfam03968 273123002543 Organic solvent tolerance protein; Region: OstA_C; pfam04453 273123002544 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 273123002545 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 273123002546 putative metal binding site [ion binding]; other site 273123002547 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 273123002548 HSP70 interaction site [polypeptide binding]; other site 273123002549 1 probable transmembrane helix predicted by TMHMM2.0 273123002550 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 273123002551 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 273123002552 active site 273123002553 Uncharacterized conserved protein [Function unknown]; Region: COG5419 273123002554 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 273123002555 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 273123002556 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 273123002557 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 273123002558 Protein of unknown function (DUF877); Region: DUF877; pfam05943 273123002559 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 273123002560 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 273123002561 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 273123002562 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 273123002563 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 273123002564 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 273123002565 Clp amino terminal domain; Region: Clp_N; pfam02861 273123002566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123002567 Walker A motif; other site 273123002568 ATP binding site [chemical binding]; other site 273123002569 Walker B motif; other site 273123002570 arginine finger; other site 273123002571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123002572 Walker A motif; other site 273123002573 ATP binding site [chemical binding]; other site 273123002574 Walker B motif; other site 273123002575 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 273123002576 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 273123002577 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 273123002578 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 273123002579 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 273123002580 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 273123002581 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 273123002582 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 273123002583 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 273123002584 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 273123002585 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 273123002586 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 273123002587 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 273123002588 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 273123002589 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 273123002590 1 probable transmembrane helix predicted by TMHMM2.0 273123002591 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 273123002592 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 273123002593 hypothetical protein; Provisional; Region: PRK07034 273123002594 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 273123002595 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 273123002596 ligand binding site [chemical binding]; other site 273123002597 1 probable transmembrane helix predicted by TMHMM2.0 273123002598 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 273123002599 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 273123002600 G1 box; other site 273123002601 GTP/Mg2+ binding site [chemical binding]; other site 273123002602 G2 box; other site 273123002603 G3 box; other site 273123002604 Switch II region; other site 273123002605 G4 box; other site 273123002606 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 273123002607 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 273123002608 3 probable transmembrane helices predicted by TMHMM2.0 273123002609 ATP-dependent helicase HepA; Validated; Region: PRK04914 273123002610 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273123002611 ATP binding site [chemical binding]; other site 273123002612 putative Mg++ binding site [ion binding]; other site 273123002613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123002614 nucleotide binding region [chemical binding]; other site 273123002615 ATP-binding site [chemical binding]; other site 273123002616 DNA polymerase II; Reviewed; Region: PRK05762 273123002617 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 273123002618 active site 273123002619 catalytic site [active] 273123002620 substrate binding site [chemical binding]; other site 273123002621 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 273123002622 active site 273123002623 metal-binding site 273123002624 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 273123002625 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 273123002626 6 probable transmembrane helices predicted by TMHMM2.0 273123002627 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 273123002628 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 273123002629 Walker A/P-loop; other site 273123002630 ATP binding site [chemical binding]; other site 273123002631 Q-loop/lid; other site 273123002632 ABC transporter signature motif; other site 273123002633 Walker B; other site 273123002634 D-loop; other site 273123002635 H-loop/switch region; other site 273123002636 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 273123002637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123002638 dimer interface [polypeptide binding]; other site 273123002639 conserved gate region; other site 273123002640 putative PBP binding loops; other site 273123002641 ABC-ATPase subunit interface; other site 273123002642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123002643 dimer interface [polypeptide binding]; other site 273123002644 conserved gate region; other site 273123002645 putative PBP binding loops; other site 273123002646 ABC-ATPase subunit interface; other site 273123002647 12 probable transmembrane helices predicted by TMHMM2.0 273123002648 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 273123002649 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 273123002650 similar to Yersinia pestis YPMT1.71 hypothetical protein (86.8% evalue=1.E-10); Salmonella typhimurium PSLT051 samB; cytoplasmic protein (92.1% evalue=2.E-12);gene remnant of a conserved hypothetical protein 273123002651 HTH-like domain; Region: HTH_21; pfam13276 273123002652 transcriptional regulator SgrR; Provisional; Region: PRK13626 273123002653 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 273123002654 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 273123002655 sugar efflux transporter; Region: 2A0120; TIGR00899 273123002656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123002657 putative substrate translocation pore; other site 273123002658 12 probable transmembrane helices predicted by TMHMM2.0 273123002659 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 273123002660 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 273123002661 substrate binding site [chemical binding]; other site 273123002662 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 273123002663 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 273123002664 substrate binding site [chemical binding]; other site 273123002665 ligand binding site [chemical binding]; other site 273123002666 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 273123002667 tartrate dehydrogenase; Region: TTC; TIGR02089 273123002668 2-isopropylmalate synthase; Validated; Region: PRK00915 273123002669 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 273123002670 active site 273123002671 catalytic residues [active] 273123002672 metal binding site [ion binding]; metal-binding site 273123002673 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 273123002674 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 273123002675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123002676 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 273123002677 putative substrate binding pocket [chemical binding]; other site 273123002678 putative dimerization interface [polypeptide binding]; other site 273123002679 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 273123002680 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 273123002681 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 273123002682 acyl-activating enzyme (AAE) consensus motif; other site 273123002683 acyl-activating enzyme (AAE) consensus motif; other site 273123002684 putative AMP binding site [chemical binding]; other site 273123002685 putative active site [active] 273123002686 putative CoA binding site [chemical binding]; other site 273123002687 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 273123002688 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 273123002689 PYR/PP interface [polypeptide binding]; other site 273123002690 dimer interface [polypeptide binding]; other site 273123002691 TPP binding site [chemical binding]; other site 273123002692 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 273123002693 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 273123002694 TPP-binding site [chemical binding]; other site 273123002695 dimer interface [polypeptide binding]; other site 273123002696 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 273123002697 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 273123002698 putative valine binding site [chemical binding]; other site 273123002699 dimer interface [polypeptide binding]; other site 273123002700 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 273123002701 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 273123002702 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123002703 DNA binding site [nucleotide binding] 273123002704 domain linker motif; other site 273123002705 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 273123002706 dimerization interface [polypeptide binding]; other site 273123002707 ligand binding site [chemical binding]; other site 273123002708 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 273123002709 3 probable transmembrane helices predicted by TMHMM2.0 273123002710 cell division protein MraZ; Reviewed; Region: PRK00326 273123002711 MraZ protein; Region: MraZ; pfam02381 273123002712 MraZ protein; Region: MraZ; pfam02381 273123002713 MraW methylase family; Region: Methyltransf_5; pfam01795 273123002714 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 273123002715 cell division protein FtsL; Provisional; Region: PRK10772 273123002716 1 probable transmembrane helix predicted by TMHMM2.0 273123002717 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 273123002718 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 273123002719 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 273123002720 1 probable transmembrane helix predicted by TMHMM2.0 273123002721 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 273123002722 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 273123002723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 273123002724 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273123002725 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 273123002726 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 273123002727 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 273123002728 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273123002729 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 273123002730 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 273123002731 Mg++ binding site [ion binding]; other site 273123002732 putative catalytic motif [active] 273123002733 putative substrate binding site [chemical binding]; other site 273123002734 10 probable transmembrane helices predicted by TMHMM2.0 273123002735 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 273123002736 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 273123002737 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 273123002738 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273123002739 1 probable transmembrane helix predicted by TMHMM2.0 273123002740 cell division protein FtsW; Provisional; Region: PRK10774 273123002741 9 probable transmembrane helices predicted by TMHMM2.0 273123002742 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 273123002743 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 273123002744 active site 273123002745 homodimer interface [polypeptide binding]; other site 273123002746 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 273123002747 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 273123002748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 273123002749 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273123002750 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 273123002751 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 273123002752 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 273123002753 cell division protein FtsQ; Provisional; Region: PRK10775 273123002754 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 273123002755 Cell division protein FtsQ; Region: FtsQ; pfam03799 273123002756 1 probable transmembrane helix predicted by TMHMM2.0 273123002757 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 273123002758 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 273123002759 Cell division protein FtsA; Region: FtsA; pfam14450 273123002760 cell division protein FtsZ; Validated; Region: PRK09330 273123002761 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 273123002762 nucleotide binding site [chemical binding]; other site 273123002763 SulA interaction site; other site 273123002764 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 273123002765 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 273123002766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 273123002767 SecA regulator SecM; Provisional; Region: PRK02943 273123002768 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 273123002769 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 273123002770 SEC-C motif; Region: SEC-C; pfam02810 273123002771 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 273123002772 active site 273123002773 8-oxo-dGMP binding site [chemical binding]; other site 273123002774 nudix motif; other site 273123002775 metal binding site [ion binding]; metal-binding site 273123002776 Transposase IS200 like; Region: Y1_Tnp; pfam01797 273123002777 DNA gyrase inhibitor; Reviewed; Region: PRK00418 273123002778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 273123002779 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 273123002780 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 273123002781 CoA-binding site [chemical binding]; other site 273123002782 ATP-binding [chemical binding]; other site 273123002783 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 273123002784 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 273123002785 active site 273123002786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 273123002787 MULE transposase domain; Region: MULE; pfam10551 273123002788 type IV pilin biogenesis protein; Provisional; Region: PRK10573 273123002789 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 273123002790 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 273123002791 3 probable transmembrane helices predicted by TMHMM2.0 273123002792 hypothetical protein; Provisional; Region: PRK10436 273123002793 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 273123002794 Walker A motif; other site 273123002795 ATP binding site [chemical binding]; other site 273123002796 Walker B motif; other site 273123002797 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 273123002798 putative major pilin subunit; Provisional; Region: PRK10574 273123002799 1 probable transmembrane helix predicted by TMHMM2.0 273123002800 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 273123002801 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 273123002802 dimerization interface [polypeptide binding]; other site 273123002803 active site 273123002804 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 273123002805 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 273123002806 amidase catalytic site [active] 273123002807 Zn binding residues [ion binding]; other site 273123002808 substrate binding site [chemical binding]; other site 273123002809 regulatory protein AmpE; Provisional; Region: PRK10987 273123002810 4 probable transmembrane helices predicted by TMHMM2.0 273123002811 aromatic amino acid transporter; Provisional; Region: PRK10238 273123002812 12 probable transmembrane helices predicted by TMHMM2.0 273123002813 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 273123002814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123002815 DNA-binding site [nucleotide binding]; DNA binding site 273123002816 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 273123002817 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 273123002818 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 273123002819 dimer interface [polypeptide binding]; other site 273123002820 TPP-binding site [chemical binding]; other site 273123002821 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 273123002822 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 273123002823 E3 interaction surface; other site 273123002824 lipoyl attachment site [posttranslational modification]; other site 273123002825 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 273123002826 E3 interaction surface; other site 273123002827 lipoyl attachment site [posttranslational modification]; other site 273123002828 e3 binding domain; Region: E3_binding; pfam02817 273123002829 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 273123002830 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 273123002831 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273123002832 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273123002833 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273123002834 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 273123002835 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 273123002836 substrate binding site [chemical binding]; other site 273123002837 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 273123002838 substrate binding site [chemical binding]; other site 273123002839 ligand binding site [chemical binding]; other site 273123002840 hypothetical protein; Provisional; Region: PRK05248 273123002841 aromatic amino acid exporter; Provisional; Region: PRK11689 273123002842 EamA-like transporter family; Region: EamA; cl17759 273123002843 10 probable transmembrane helices predicted by TMHMM2.0 273123002844 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 273123002845 spermidine synthase; Provisional; Region: PRK00811 273123002846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123002847 S-adenosylmethionine binding site [chemical binding]; other site 273123002848 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 273123002849 multicopper oxidase; Provisional; Region: PRK10965 273123002850 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 273123002851 Multicopper oxidase; Region: Cu-oxidase; pfam00394 273123002852 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 273123002853 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273123002854 active site 273123002855 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 273123002856 active site clefts [active] 273123002857 zinc binding site [ion binding]; other site 273123002858 dimer interface [polypeptide binding]; other site 273123002859 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 273123002860 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 273123002861 Walker A/P-loop; other site 273123002862 ATP binding site [chemical binding]; other site 273123002863 Q-loop/lid; other site 273123002864 ABC transporter signature motif; other site 273123002865 Walker B; other site 273123002866 D-loop; other site 273123002867 H-loop/switch region; other site 273123002868 inner membrane transport permease; Provisional; Region: PRK15066 273123002869 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 273123002870 6 probable transmembrane helices predicted by TMHMM2.0 273123002871 Bacterial SH3 domain; Region: SH3_3; cl17532 273123002872 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 273123002873 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 273123002874 putative active site [active] 273123002875 putative metal binding site [ion binding]; other site 273123002876 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 273123002877 tetramerization interface [polypeptide binding]; other site 273123002878 active site 273123002879 pantoate--beta-alanine ligase; Region: panC; TIGR00018 273123002880 Pantoate-beta-alanine ligase; Region: PanC; cd00560 273123002881 active site 273123002882 ATP-binding site [chemical binding]; other site 273123002883 pantoate-binding site; other site 273123002884 HXXH motif; other site 273123002885 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 273123002886 oligomerization interface [polypeptide binding]; other site 273123002887 active site 273123002888 metal binding site [ion binding]; metal-binding site 273123002889 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 273123002890 catalytic center binding site [active] 273123002891 ATP binding site [chemical binding]; other site 273123002892 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 273123002893 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 273123002894 active site 273123002895 NTP binding site [chemical binding]; other site 273123002896 metal binding triad [ion binding]; metal-binding site 273123002897 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 273123002898 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 273123002899 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 273123002900 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 273123002901 active site 273123002902 nucleotide binding site [chemical binding]; other site 273123002903 HIGH motif; other site 273123002904 KMSKS motif; other site 273123002905 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 273123002906 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 273123002907 2'-5' RNA ligase; Provisional; Region: PRK15124 273123002908 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 273123002909 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 273123002910 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273123002911 ATP binding site [chemical binding]; other site 273123002912 putative Mg++ binding site [ion binding]; other site 273123002913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123002914 nucleotide binding region [chemical binding]; other site 273123002915 ATP-binding site [chemical binding]; other site 273123002916 Helicase associated domain (HA2); Region: HA2; pfam04408 273123002917 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 273123002918 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 273123002919 Transglycosylase; Region: Transgly; pfam00912 273123002920 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 273123002921 1 probable transmembrane helix predicted by TMHMM2.0 273123002922 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 273123002923 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 273123002924 Walker A/P-loop; other site 273123002925 ATP binding site [chemical binding]; other site 273123002926 Q-loop/lid; other site 273123002927 ABC transporter signature motif; other site 273123002928 Walker B; other site 273123002929 D-loop; other site 273123002930 H-loop/switch region; other site 273123002931 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 273123002932 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 273123002933 siderophore binding site; other site 273123002934 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 273123002935 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123002936 ABC-ATPase subunit interface; other site 273123002937 dimer interface [polypeptide binding]; other site 273123002938 putative PBP binding regions; other site 273123002939 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123002940 ABC-ATPase subunit interface; other site 273123002941 dimer interface [polypeptide binding]; other site 273123002942 putative PBP binding regions; other site 273123002943 20 probable transmembrane helices predicted by TMHMM2.0 273123002944 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 273123002945 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 273123002946 inhibitor-cofactor binding pocket; inhibition site 273123002947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123002948 catalytic residue [active] 273123002949 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 273123002950 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 273123002951 Cl- selectivity filter; other site 273123002952 Cl- binding residues [ion binding]; other site 273123002953 pore gating glutamate residue; other site 273123002954 dimer interface [polypeptide binding]; other site 273123002955 H+/Cl- coupling transport residue; other site 273123002956 10 probable transmembrane helices predicted by TMHMM2.0 273123002957 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 273123002958 hypothetical protein; Provisional; Region: PRK10578 273123002959 UPF0126 domain; Region: UPF0126; pfam03458 273123002960 UPF0126 domain; Region: UPF0126; pfam03458 273123002961 7 probable transmembrane helices predicted by TMHMM2.0 273123002962 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 273123002963 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 273123002964 cobalamin binding residues [chemical binding]; other site 273123002965 putative BtuC binding residues; other site 273123002966 dimer interface [polypeptide binding]; other site 273123002967 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 273123002968 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 273123002969 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 273123002970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273123002971 Zn2+ binding site [ion binding]; other site 273123002972 Mg2+ binding site [ion binding]; other site 273123002973 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 273123002974 serine endoprotease; Provisional; Region: PRK10942 273123002975 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 273123002976 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 273123002977 protein binding site [polypeptide binding]; other site 273123002978 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 273123002979 1 probable transmembrane helix predicted by TMHMM2.0 273123002980 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 273123002981 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 273123002982 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123002983 dimerization interface [polypeptide binding]; other site 273123002984 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123002985 dimer interface [polypeptide binding]; other site 273123002986 phosphorylation site [posttranslational modification] 273123002987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123002988 ATP binding site [chemical binding]; other site 273123002989 Mg2+ binding site [ion binding]; other site 273123002990 G-X-G motif; other site 273123002991 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 273123002992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123002993 active site 273123002994 phosphorylation site [posttranslational modification] 273123002995 intermolecular recognition site; other site 273123002996 dimerization interface [polypeptide binding]; other site 273123002997 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 273123002998 putative binding surface; other site 273123002999 active site 273123003000 2 probable transmembrane helices predicted by TMHMM2.0 273123003001 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 273123003002 HD domain; Region: HD_4; pfam13328 273123003003 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 273123003004 synthetase active site [active] 273123003005 NTP binding site [chemical binding]; other site 273123003006 metal binding site [ion binding]; metal-binding site 273123003007 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 273123003008 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 273123003009 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 273123003010 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 273123003011 homodimer interface [polypeptide binding]; other site 273123003012 metal binding site [ion binding]; metal-binding site 273123003013 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 273123003014 homodimer interface [polypeptide binding]; other site 273123003015 active site 273123003016 putative chemical substrate binding site [chemical binding]; other site 273123003017 metal binding site [ion binding]; metal-binding site 273123003018 CTP synthetase; Validated; Region: pyrG; PRK05380 273123003019 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 273123003020 Catalytic site [active] 273123003021 active site 273123003022 UTP binding site [chemical binding]; other site 273123003023 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 273123003024 active site 273123003025 putative oxyanion hole; other site 273123003026 catalytic triad [active] 273123003027 1 probable transmembrane helix predicted by TMHMM2.0 273123003028 enolase; Provisional; Region: eno; PRK00077 273123003029 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 273123003030 dimer interface [polypeptide binding]; other site 273123003031 metal binding site [ion binding]; metal-binding site 273123003032 substrate binding pocket [chemical binding]; other site 273123003033 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 273123003034 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 273123003035 E-class dimer interface [polypeptide binding]; other site 273123003036 P-class dimer interface [polypeptide binding]; other site 273123003037 active site 273123003038 Cu2+ binding site [ion binding]; other site 273123003039 Zn2+ binding site [ion binding]; other site 273123003040 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 273123003041 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 273123003042 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 273123003043 active site 273123003044 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 273123003045 Flavodoxin; Region: Flavodoxin_1; pfam00258 273123003046 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 273123003047 FAD binding pocket [chemical binding]; other site 273123003048 FAD binding motif [chemical binding]; other site 273123003049 catalytic residues [active] 273123003050 NAD binding pocket [chemical binding]; other site 273123003051 phosphate binding motif [ion binding]; other site 273123003052 beta-alpha-beta structure motif; other site 273123003053 sulfite reductase subunit beta; Provisional; Region: PRK13504 273123003054 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 273123003055 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 273123003056 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 273123003057 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 273123003058 Active Sites [active] 273123003059 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 273123003060 YcfA-like protein; Region: YcfA; pfam07927 273123003061 siroheme synthase; Provisional; Region: cysG; PRK10637 273123003062 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 273123003063 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 273123003064 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 273123003065 active site 273123003066 SAM binding site [chemical binding]; other site 273123003067 homodimer interface [polypeptide binding]; other site 273123003068 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 273123003069 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 273123003070 Active Sites [active] 273123003071 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 273123003072 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 273123003073 CysD dimerization site [polypeptide binding]; other site 273123003074 G1 box; other site 273123003075 putative GEF interaction site [polypeptide binding]; other site 273123003076 GTP/Mg2+ binding site [chemical binding]; other site 273123003077 Switch I region; other site 273123003078 G2 box; other site 273123003079 G3 box; other site 273123003080 Switch II region; other site 273123003081 G4 box; other site 273123003082 G5 box; other site 273123003083 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 273123003084 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 273123003085 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 273123003086 ligand-binding site [chemical binding]; other site 273123003087 hypothetical protein; Provisional; Region: PRK10726 273123003088 3 probable transmembrane helices predicted by TMHMM2.0 273123003089 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 273123003090 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 273123003091 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 273123003092 substrate binding site; other site 273123003093 dimer interface; other site 273123003094 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 273123003095 homotrimer interaction site [polypeptide binding]; other site 273123003096 zinc binding site [ion binding]; other site 273123003097 CDP-binding sites; other site 273123003098 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 273123003099 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 273123003100 Permutation of conserved domain; other site 273123003101 active site 273123003102 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 273123003103 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 273123003104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123003105 S-adenosylmethionine binding site [chemical binding]; other site 273123003106 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 273123003107 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273123003108 Peptidase family M23; Region: Peptidase_M23; pfam01551 273123003109 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 273123003110 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 273123003111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273123003112 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 273123003113 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273123003114 DNA binding residues [nucleotide binding] 273123003115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 273123003116 MULE transposase domain; Region: MULE; pfam10551 273123003117 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 273123003118 MutS domain I; Region: MutS_I; pfam01624 273123003119 MutS domain II; Region: MutS_II; pfam05188 273123003120 MutS domain III; Region: MutS_III; pfam05192 273123003121 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 273123003122 Walker A/P-loop; other site 273123003123 ATP binding site [chemical binding]; other site 273123003124 Q-loop/lid; other site 273123003125 ABC transporter signature motif; other site 273123003126 Walker B; other site 273123003127 D-loop; other site 273123003128 H-loop/switch region; other site 273123003129 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 273123003130 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 273123003131 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 273123003132 putative NAD(P) binding site [chemical binding]; other site 273123003133 catalytic Zn binding site [ion binding]; other site 273123003134 structural Zn binding site [ion binding]; other site 273123003135 short chain dehydrogenase; Provisional; Region: PRK06841 273123003136 classical (c) SDRs; Region: SDR_c; cd05233 273123003137 NAD(P) binding site [chemical binding]; other site 273123003138 active site 273123003139 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 273123003140 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 273123003141 DAK2 domain; Region: Dak2; pfam02734 273123003142 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 273123003143 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 273123003144 DNA binding residues [nucleotide binding] 273123003145 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 273123003146 arsenical pump membrane protein; Provisional; Region: PRK15445 273123003147 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 273123003148 transmembrane helices; other site 273123003149 9 probable transmembrane helices predicted by TMHMM2.0 273123003150 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273123003151 dimerization interface [polypeptide binding]; other site 273123003152 putative DNA binding site [nucleotide binding]; other site 273123003153 putative Zn2+ binding site [ion binding]; other site 273123003154 FaeA-like protein; Region: FaeA; pfam04703 273123003155 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 273123003156 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123003157 substrate binding pocket [chemical binding]; other site 273123003158 membrane-bound complex binding site; other site 273123003159 hinge residues; other site 273123003160 Haem-binding domain; Region: Haem_bd; pfam14376 273123003161 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 273123003162 1 probable transmembrane helix predicted by TMHMM2.0 273123003163 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 273123003164 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 273123003165 N-terminal plug; other site 273123003166 ligand-binding site [chemical binding]; other site 273123003167 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 273123003168 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 273123003169 active site 273123003170 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 273123003171 fumarate hydratase; Provisional; Region: PRK15389 273123003172 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 273123003173 Fumarase C-terminus; Region: Fumerase_C; pfam05683 273123003174 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 273123003175 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 273123003176 putative N- and C-terminal domain interface [polypeptide binding]; other site 273123003177 putative active site [active] 273123003178 MgATP binding site [chemical binding]; other site 273123003179 catalytic site [active] 273123003180 metal binding site [ion binding]; metal-binding site 273123003181 putative xylulose binding site [chemical binding]; other site 273123003182 Putative L-xylulose-5-phosphate 3-epimerase [Carbohydrate transport and metabolism]; Region: SgaU; COG3623 273123003183 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 273123003184 AP (apurinic/apyrimidinic) site pocket; other site 273123003185 DNA interaction; other site 273123003186 Metal-binding active site; metal-binding site 273123003187 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123003188 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123003189 TM-ABC transporter signature motif; other site 273123003190 10 probable transmembrane helices predicted by TMHMM2.0 273123003191 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123003192 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123003193 TM-ABC transporter signature motif; other site 273123003194 8 probable transmembrane helices predicted by TMHMM2.0 273123003195 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123003196 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123003197 Walker A/P-loop; other site 273123003198 ATP binding site [chemical binding]; other site 273123003199 Q-loop/lid; other site 273123003200 ABC transporter signature motif; other site 273123003201 Walker B; other site 273123003202 D-loop; other site 273123003203 H-loop/switch region; other site 273123003204 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123003205 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 273123003206 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 273123003207 ligand binding site [chemical binding]; other site 273123003208 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 273123003209 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 273123003210 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 273123003211 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK13213 273123003212 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 273123003213 intersubunit interface [polypeptide binding]; other site 273123003214 active site 273123003215 Zn2+ binding site [ion binding]; other site 273123003216 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 273123003217 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 273123003218 putative [Fe4-S4] binding site [ion binding]; other site 273123003219 putative molybdopterin cofactor binding site [chemical binding]; other site 273123003220 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 273123003221 putative molybdopterin cofactor binding site; other site 273123003222 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 273123003223 4Fe-4S binding domain; Region: Fer4; cl02805 273123003224 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 273123003225 8 probable transmembrane helices predicted by TMHMM2.0 273123003226 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 273123003227 cytochrome b561; Provisional; Region: PRK11513 273123003228 4 probable transmembrane helices predicted by TMHMM2.0 273123003229 Soluble cytochrome b562 [Energy production and conversion]; Region: CybC; COG3783 273123003230 1 probable transmembrane helix predicted by TMHMM2.0 273123003231 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 273123003232 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 273123003233 dimer interface [polypeptide binding]; other site 273123003234 active site 273123003235 heme binding site [chemical binding]; other site 273123003236 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 273123003237 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 273123003238 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 273123003239 ligand binding site [chemical binding]; other site 273123003240 dimerization interface [polypeptide binding]; other site 273123003241 1 probable transmembrane helix predicted by TMHMM2.0 273123003242 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5618 273123003243 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123003244 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123003245 Walker A/P-loop; other site 273123003246 ATP binding site [chemical binding]; other site 273123003247 Q-loop/lid; other site 273123003248 ABC transporter signature motif; other site 273123003249 Walker B; other site 273123003250 D-loop; other site 273123003251 H-loop/switch region; other site 273123003252 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123003253 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123003254 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123003255 TM-ABC transporter signature motif; other site 273123003256 10 probable transmembrane helices predicted by TMHMM2.0 273123003257 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 273123003258 TPP-binding site [chemical binding]; other site 273123003259 dimer interface [polypeptide binding]; other site 273123003260 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 273123003261 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 273123003262 PYR/PP interface [polypeptide binding]; other site 273123003263 dimer interface [polypeptide binding]; other site 273123003264 TPP binding site [chemical binding]; other site 273123003265 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 273123003266 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 273123003267 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 273123003268 N- and C-terminal domain interface [polypeptide binding]; other site 273123003269 active site 273123003270 MgATP binding site [chemical binding]; other site 273123003271 catalytic site [active] 273123003272 metal binding site [ion binding]; metal-binding site 273123003273 putative homotetramer interface [polypeptide binding]; other site 273123003274 putative homodimer interface [polypeptide binding]; other site 273123003275 glycerol binding site [chemical binding]; other site 273123003276 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 273123003277 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 273123003278 hexamer (dimer of trimers) interface [polypeptide binding]; other site 273123003279 substrate binding site [chemical binding]; other site 273123003280 trimer interface [polypeptide binding]; other site 273123003281 Mn binding site [ion binding]; other site 273123003282 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 273123003283 MarR family; Region: MarR_2; cl17246 273123003284 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 273123003285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123003286 putative MFS family transporter protein; Provisional; Region: PRK03633 273123003287 putative substrate translocation pore; other site 273123003288 12 probable transmembrane helices predicted by TMHMM2.0 273123003289 hypothetical protein; Validated; Region: PRK03661 273123003290 recombinase A; Provisional; Region: recA; PRK09354 273123003291 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 273123003292 hexamer interface [polypeptide binding]; other site 273123003293 Walker A motif; other site 273123003294 ATP binding site [chemical binding]; other site 273123003295 Walker B motif; other site 273123003296 recombination regulator RecX; Reviewed; Region: recX; PRK00117 273123003297 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 273123003298 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 273123003299 motif 1; other site 273123003300 active site 273123003301 motif 2; other site 273123003302 motif 3; other site 273123003303 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 273123003304 DHHA1 domain; Region: DHHA1; pfam02272 273123003305 carbon storage regulator; Provisional; Region: PRK01712 273123003306 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 273123003307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123003308 motif II; other site 273123003309 Predicted membrane protein [Function unknown]; Region: COG1238 273123003310 4 probable transmembrane helices predicted by TMHMM2.0 273123003311 glutamate--cysteine ligase; Provisional; Region: PRK02107 273123003312 S-ribosylhomocysteinase; Provisional; Region: PRK02260 273123003313 hypothetical protein; Provisional; Region: PRK11573 273123003314 Domain of unknown function DUF21; Region: DUF21; pfam01595 273123003315 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 273123003316 Transporter associated domain; Region: CorC_HlyC; smart01091 273123003317 4 probable transmembrane helices predicted by TMHMM2.0 273123003318 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 273123003319 8 probable transmembrane helices predicted by TMHMM2.0 273123003320 signal recognition particle protein; Provisional; Region: PRK10867 273123003321 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 273123003322 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 273123003323 P loop; other site 273123003324 GTP binding site [chemical binding]; other site 273123003325 Signal peptide binding domain; Region: SRP_SPB; pfam02978 273123003326 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 273123003327 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 273123003328 RimM N-terminal domain; Region: RimM; pfam01782 273123003329 PRC-barrel domain; Region: PRC; pfam05239 273123003330 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 273123003331 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 273123003332 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 273123003333 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 273123003334 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 273123003335 11 probable transmembrane helices predicted by TMHMM2.0 273123003336 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 273123003337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123003338 active site 273123003339 phosphorylation site [posttranslational modification] 273123003340 intermolecular recognition site; other site 273123003341 dimerization interface [polypeptide binding]; other site 273123003342 LytTr DNA-binding domain; Region: LytTR; pfam04397 273123003343 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 273123003344 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 273123003345 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 273123003346 Chorismate mutase type II; Region: CM_2; cl00693 273123003347 prephenate dehydrogenase; Validated; Region: PRK08507 273123003348 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 273123003349 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 273123003350 Prephenate dehydratase; Region: PDT; pfam00800 273123003351 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 273123003352 putative L-Phe binding site [chemical binding]; other site 273123003353 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 273123003354 30S subunit binding site; other site 273123003355 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 273123003356 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 273123003357 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273123003358 RNA binding surface [nucleotide binding]; other site 273123003359 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 273123003360 active site 273123003361 hypothetical protein; Provisional; Region: PRK10723 273123003362 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 273123003363 protein disaggregation chaperone; Provisional; Region: PRK10865 273123003364 Clp amino terminal domain; Region: Clp_N; pfam02861 273123003365 Clp amino terminal domain; Region: Clp_N; pfam02861 273123003366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123003367 Walker A motif; other site 273123003368 ATP binding site [chemical binding]; other site 273123003369 Walker B motif; other site 273123003370 arginine finger; other site 273123003371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123003372 Walker A motif; other site 273123003373 ATP binding site [chemical binding]; other site 273123003374 Walker B motif; other site 273123003375 arginine finger; other site 273123003376 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 273123003377 lipoprotein; Provisional; Region: PRK10759 273123003378 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 273123003379 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 273123003380 domain interface [polypeptide binding]; other site 273123003381 putative active site [active] 273123003382 catalytic site [active] 273123003383 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 273123003384 domain interface [polypeptide binding]; other site 273123003385 putative active site [active] 273123003386 catalytic site [active] 273123003387 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 273123003388 CoA binding domain; Region: CoA_binding_2; pfam13380 273123003389 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 273123003390 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 273123003391 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 273123003392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273123003393 Coenzyme A binding pocket [chemical binding]; other site 273123003394 Uncharacterized conserved protein [Function unknown]; Region: COG3148 273123003395 thioredoxin 2; Provisional; Region: PRK10996 273123003396 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 273123003397 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273123003398 catalytic residues [active] 273123003399 putative methyltransferase; Provisional; Region: PRK10864 273123003400 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 273123003401 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 273123003402 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 273123003403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123003404 putative substrate translocation pore; other site 273123003405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123003406 13 probable transmembrane helices predicted by TMHMM2.0 273123003407 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 273123003408 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123003409 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123003410 1 probable transmembrane helix predicted by TMHMM2.0 273123003411 transcriptional repressor MprA; Provisional; Region: PRK10870 273123003412 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 273123003413 putative L-valine exporter; Provisional; Region: PRK10408 273123003414 3 probable transmembrane helices predicted by TMHMM2.0 273123003415 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 273123003416 5 probable transmembrane helices predicted by TMHMM2.0 273123003417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123003418 putative substrate translocation pore; other site 273123003419 12 probable transmembrane helices predicted by TMHMM2.0 273123003420 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 273123003421 amidase; Provisional; Region: PRK09201 273123003422 Amidase; Region: Amidase; cl11426 273123003423 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 273123003424 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273123003425 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273123003426 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273123003427 putative active site [active] 273123003428 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 273123003429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123003430 substrate binding pocket [chemical binding]; other site 273123003431 membrane-bound complex binding site; other site 273123003432 hinge residues; other site 273123003433 1 probable transmembrane helix predicted by TMHMM2.0 273123003434 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 273123003435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123003436 dimer interface [polypeptide binding]; other site 273123003437 conserved gate region; other site 273123003438 putative PBP binding loops; other site 273123003439 ABC-ATPase subunit interface; other site 273123003440 4 probable transmembrane helices predicted by TMHMM2.0 273123003441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123003442 dimer interface [polypeptide binding]; other site 273123003443 conserved gate region; other site 273123003444 putative PBP binding loops; other site 273123003445 ABC-ATPase subunit interface; other site 273123003446 5 probable transmembrane helices predicted by TMHMM2.0 273123003447 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 273123003448 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 273123003449 Walker A/P-loop; other site 273123003450 ATP binding site [chemical binding]; other site 273123003451 Q-loop/lid; other site 273123003452 ABC transporter signature motif; other site 273123003453 Walker B; other site 273123003454 D-loop; other site 273123003455 H-loop/switch region; other site 273123003456 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 273123003457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123003458 catalytic residue [active] 273123003459 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 273123003460 allantoate amidohydrolase; Reviewed; Region: PRK09290 273123003461 active site 273123003462 metal binding site [ion binding]; metal-binding site 273123003463 dimer interface [polypeptide binding]; other site 273123003464 C-N hydrolase family amidase; Provisional; Region: PRK10438 273123003465 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 273123003466 active site 273123003467 catalytic triad [active] 273123003468 dimer interface [polypeptide binding]; other site 273123003469 methionine aminotransferase; Validated; Region: PRK09082 273123003470 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123003471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123003472 homodimer interface [polypeptide binding]; other site 273123003473 catalytic residue [active] 273123003474 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 273123003475 intersubunit interface [polypeptide binding]; other site 273123003476 active site 273123003477 Zn2+ binding site [ion binding]; other site 273123003478 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 273123003479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 273123003480 motif II; other site 273123003481 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 273123003482 Cupin domain; Region: Cupin_2; cl17218 273123003483 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 273123003484 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 273123003485 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 273123003486 Phosphotransferase enzyme family; Region: APH; pfam01636 273123003487 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 273123003488 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 273123003489 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 273123003490 1 probable transmembrane helix predicted by TMHMM2.0 273123003491 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 273123003492 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 273123003493 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 273123003494 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 273123003495 active site 273123003496 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 273123003497 2 probable transmembrane helices predicted by TMHMM2.0 273123003498 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 273123003499 dimer interface [polypeptide binding]; other site 273123003500 active site 273123003501 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 273123003502 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 273123003503 putative active site [active] 273123003504 putative dimer interface [polypeptide binding]; other site 273123003505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 273123003506 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 273123003507 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 273123003508 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 273123003509 E3 interaction surface; other site 273123003510 lipoyl attachment site [posttranslational modification]; other site 273123003511 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 273123003512 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 273123003513 8 probable transmembrane helices predicted by TMHMM2.0 273123003514 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 273123003515 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 273123003516 1 probable transmembrane helix predicted by TMHMM2.0 273123003517 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 273123003518 5 probable transmembrane helices predicted by TMHMM2.0 273123003519 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 273123003520 6 probable transmembrane helices predicted by TMHMM2.0 273123003521 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 273123003522 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 273123003523 catalytic loop [active] 273123003524 iron binding site [ion binding]; other site 273123003525 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 273123003526 FAD binding pocket [chemical binding]; other site 273123003527 FAD binding motif [chemical binding]; other site 273123003528 phosphate binding motif [ion binding]; other site 273123003529 beta-alpha-beta structure motif; other site 273123003530 NAD binding pocket [chemical binding]; other site 273123003531 1 probable transmembrane helix predicted by TMHMM2.0 273123003532 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 273123003533 ApbE family; Region: ApbE; pfam02424 273123003534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 273123003535 1 probable transmembrane helix predicted by TMHMM2.0 273123003536 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 273123003537 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 273123003538 putative active site [active] 273123003539 catalytic site [active] 273123003540 putative metal binding site [ion binding]; other site 273123003541 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 273123003542 active site 273123003543 DNA polymerase IV; Validated; Region: PRK02406 273123003544 DNA binding site [nucleotide binding] 273123003545 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 273123003546 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 273123003547 metal binding site [ion binding]; metal-binding site 273123003548 dimer interface [polypeptide binding]; other site 273123003549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123003550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123003551 LysR substrate binding domain; Region: LysR_substrate; pfam03466 273123003552 dimerization interface [polypeptide binding]; other site 273123003553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 273123003554 Chitin binding domain; Region: Chitin_bind_3; pfam03067 273123003555 PKD domain; Region: PKD; pfam00801 273123003556 3 probable transmembrane helices predicted by TMHMM2.0 273123003557 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273123003558 active site 273123003559 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 273123003560 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 273123003561 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 273123003562 gamma-glutamyl kinase; Provisional; Region: PRK05429 273123003563 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 273123003564 nucleotide binding site [chemical binding]; other site 273123003565 homotetrameric interface [polypeptide binding]; other site 273123003566 putative phosphate binding site [ion binding]; other site 273123003567 putative allosteric binding site; other site 273123003568 PUA domain; Region: PUA; pfam01472 273123003569 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 273123003570 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 273123003571 putative catalytic cysteine [active] 273123003572 Flagellar regulator YcgR; Region: YcgR; pfam07317 273123003573 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 273123003574 PilZ domain; Region: PilZ; pfam07238 273123003575 2 probable transmembrane helices predicted by TMHMM2.0 273123003576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123003577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 273123003578 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 273123003579 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 273123003580 ADP binding site [chemical binding]; other site 273123003581 magnesium binding site [ion binding]; other site 273123003582 putative shikimate binding site; other site 273123003583 similar to Yersinia pestis YPO3214 with a frameshift 273123003584 hypothetical protein; Provisional; Region: PRK10579 273123003585 recombination associated protein; Reviewed; Region: rdgC; PRK00321 273123003586 fructokinase; Reviewed; Region: PRK09557 273123003587 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 273123003588 nucleotide binding site [chemical binding]; other site 273123003589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123003590 AAA domain; Region: AAA_23; pfam13476 273123003591 Walker A/P-loop; other site 273123003592 ATP binding site [chemical binding]; other site 273123003593 Q-loop/lid; other site 273123003594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123003595 ABC transporter signature motif; other site 273123003596 Walker B; other site 273123003597 D-loop; other site 273123003598 H-loop/switch region; other site 273123003599 exonuclease subunit SbcD; Provisional; Region: PRK10966 273123003600 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 273123003601 active site 273123003602 metal binding site [ion binding]; metal-binding site 273123003603 DNA binding site [nucleotide binding] 273123003604 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 273123003605 transcriptional regulator PhoB; Provisional; Region: PRK10161 273123003606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123003607 active site 273123003608 phosphorylation site [posttranslational modification] 273123003609 intermolecular recognition site; other site 273123003610 dimerization interface [polypeptide binding]; other site 273123003611 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123003612 DNA binding site [nucleotide binding] 273123003613 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 273123003614 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 273123003615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273123003616 putative active site [active] 273123003617 heme pocket [chemical binding]; other site 273123003618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123003619 dimer interface [polypeptide binding]; other site 273123003620 phosphorylation site [posttranslational modification] 273123003621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123003622 ATP binding site [chemical binding]; other site 273123003623 Mg2+ binding site [ion binding]; other site 273123003624 G-X-G motif; other site 273123003625 1 probable transmembrane helix predicted by TMHMM2.0 273123003626 PBP superfamily domain; Region: PBP_like_2; cl17296 273123003627 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 273123003628 12 probable transmembrane helices predicted by TMHMM2.0 273123003629 putative proline-specific permease; Provisional; Region: proY; PRK10580 273123003630 Spore germination protein; Region: Spore_permease; cl17796 273123003631 12 probable transmembrane helices predicted by TMHMM2.0 273123003632 maltodextrin glucosidase; Provisional; Region: PRK10785 273123003633 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 273123003634 homodimer interface [polypeptide binding]; other site 273123003635 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 273123003636 active site 273123003637 homodimer interface [polypeptide binding]; other site 273123003638 catalytic site [active] 273123003639 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 273123003640 C factor cell-cell signaling protein; Provisional; Region: PRK09009 273123003641 NADP binding site [chemical binding]; other site 273123003642 homodimer interface [polypeptide binding]; other site 273123003643 active site 273123003644 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 273123003645 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 273123003646 peroxidase; Provisional; Region: PRK15000 273123003647 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 273123003648 dimer interface [polypeptide binding]; other site 273123003649 decamer (pentamer of dimers) interface [polypeptide binding]; other site 273123003650 catalytic triad [active] 273123003651 peroxidatic and resolving cysteines [active] 273123003652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3124 273123003653 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 273123003654 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 273123003655 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 273123003656 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 273123003657 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 273123003658 1 probable transmembrane helix predicted by TMHMM2.0 273123003659 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 273123003660 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 273123003661 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 273123003662 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 273123003663 6 probable transmembrane helices predicted by TMHMM2.0 273123003664 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 273123003665 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 273123003666 Protein export membrane protein; Region: SecD_SecF; pfam02355 273123003667 6 probable transmembrane helices predicted by TMHMM2.0 273123003668 1 probable transmembrane helix predicted by TMHMM2.0 273123003669 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 273123003670 ATP cone domain; Region: ATP-cone; pfam03477 273123003671 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 273123003672 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 273123003673 catalytic motif [active] 273123003674 Zn binding site [ion binding]; other site 273123003675 RibD C-terminal domain; Region: RibD_C; cl17279 273123003676 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 273123003677 homopentamer interface [polypeptide binding]; other site 273123003678 active site 273123003679 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 273123003680 putative RNA binding site [nucleotide binding]; other site 273123003681 thiamine monophosphate kinase; Provisional; Region: PRK05731 273123003682 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 273123003683 ATP binding site [chemical binding]; other site 273123003684 dimerization interface [polypeptide binding]; other site 273123003685 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 273123003686 tetramer interfaces [polypeptide binding]; other site 273123003687 binuclear metal-binding site [ion binding]; other site 273123003688 4 probable transmembrane helices predicted by TMHMM2.0 273123003689 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 273123003690 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 273123003691 TPP-binding site; other site 273123003692 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 273123003693 PYR/PP interface [polypeptide binding]; other site 273123003694 dimer interface [polypeptide binding]; other site 273123003695 TPP binding site [chemical binding]; other site 273123003696 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 273123003697 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 273123003698 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 273123003699 substrate binding pocket [chemical binding]; other site 273123003700 chain length determination region; other site 273123003701 substrate-Mg2+ binding site; other site 273123003702 catalytic residues [active] 273123003703 aspartate-rich region 1; other site 273123003704 active site lid residues [active] 273123003705 aspartate-rich region 2; other site 273123003706 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 273123003707 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 273123003708 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 273123003709 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 273123003710 Ligand Binding Site [chemical binding]; other site 273123003711 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 273123003712 active site residue [active] 273123003713 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 273123003714 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 273123003715 conserved cys residue [active] 273123003716 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 273123003717 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 273123003718 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 273123003719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 273123003720 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 273123003721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123003722 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273123003723 putative substrate translocation pore; other site 273123003724 12 probable transmembrane helices predicted by TMHMM2.0 273123003725 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 273123003726 UbiA prenyltransferase family; Region: UbiA; pfam01040 273123003727 9 probable transmembrane helices predicted by TMHMM2.0 273123003728 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 273123003729 3 probable transmembrane helices predicted by TMHMM2.0 273123003730 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 273123003731 Subunit I/III interface [polypeptide binding]; other site 273123003732 Subunit III/IV interface [polypeptide binding]; other site 273123003733 5 probable transmembrane helices predicted by TMHMM2.0 273123003734 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 273123003735 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 273123003736 D-pathway; other site 273123003737 Putative ubiquinol binding site [chemical binding]; other site 273123003738 Low-spin heme (heme b) binding site [chemical binding]; other site 273123003739 Putative water exit pathway; other site 273123003740 Binuclear center (heme o3/CuB) [ion binding]; other site 273123003741 K-pathway; other site 273123003742 Putative proton exit pathway; other site 273123003743 14 probable transmembrane helices predicted by TMHMM2.0 273123003744 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 273123003745 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 273123003746 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 273123003747 3 probable transmembrane helices predicted by TMHMM2.0 273123003748 hypothetical protein; Provisional; Region: PRK11528 273123003749 muropeptide transporter; Reviewed; Region: ampG; PRK11902 273123003750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123003751 putative substrate translocation pore; other site 273123003752 14 probable transmembrane helices predicted by TMHMM2.0 273123003753 hypothetical protein; Provisional; Region: PRK11627 273123003754 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 273123003755 transcriptional regulator BolA; Provisional; Region: PRK11628 273123003756 trigger factor; Provisional; Region: tig; PRK01490 273123003757 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 273123003758 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 273123003759 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 273123003760 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 273123003761 oligomer interface [polypeptide binding]; other site 273123003762 active site residues [active] 273123003763 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 273123003764 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 273123003765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123003766 Walker A motif; other site 273123003767 ATP binding site [chemical binding]; other site 273123003768 Walker B motif; other site 273123003769 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 273123003770 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 273123003771 Found in ATP-dependent protease La (LON); Region: LON; smart00464 273123003772 Found in ATP-dependent protease La (LON); Region: LON; smart00464 273123003773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123003774 Walker A motif; other site 273123003775 ATP binding site [chemical binding]; other site 273123003776 Walker B motif; other site 273123003777 arginine finger; other site 273123003778 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 273123003779 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 273123003780 IHF dimer interface [polypeptide binding]; other site 273123003781 IHF - DNA interface [nucleotide binding]; other site 273123003782 periplasmic folding chaperone; Provisional; Region: PRK10788 273123003783 SurA N-terminal domain; Region: SurA_N_3; cl07813 273123003784 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 273123003785 1 probable transmembrane helix predicted by TMHMM2.0 273123003786 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 273123003787 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 273123003788 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 273123003789 active site 273123003790 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 273123003791 Ligand Binding Site [chemical binding]; other site 273123003792 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 273123003793 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 273123003794 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 273123003795 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 273123003796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123003797 active site 273123003798 motif I; other site 273123003799 motif II; other site 273123003800 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 273123003801 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 273123003802 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123003803 catalytic residue [active] 273123003804 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 273123003805 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273123003806 putative DNA binding site [nucleotide binding]; other site 273123003807 putative Zn2+ binding site [ion binding]; other site 273123003808 AsnC family; Region: AsnC_trans_reg; pfam01037 273123003809 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 273123003810 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273123003811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123003812 Walker A/P-loop; other site 273123003813 ATP binding site [chemical binding]; other site 273123003814 Q-loop/lid; other site 273123003815 ABC transporter signature motif; other site 273123003816 Walker B; other site 273123003817 D-loop; other site 273123003818 H-loop/switch region; other site 273123003819 6 probable transmembrane helices predicted by TMHMM2.0 273123003820 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 273123003821 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273123003822 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 273123003823 Walker A/P-loop; other site 273123003824 ATP binding site [chemical binding]; other site 273123003825 Q-loop/lid; other site 273123003826 ABC transporter signature motif; other site 273123003827 Walker B; other site 273123003828 D-loop; other site 273123003829 H-loop/switch region; other site 273123003830 5 probable transmembrane helices predicted by TMHMM2.0 273123003831 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 273123003832 Nitrogen regulatory protein P-II; Region: P-II; smart00938 273123003833 ammonium transporter; Provisional; Region: PRK10666 273123003834 12 probable transmembrane helices predicted by TMHMM2.0 273123003835 acyl-CoA thioesterase II; Provisional; Region: PRK10526 273123003836 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 273123003837 active site 273123003838 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 273123003839 catalytic triad [active] 273123003840 dimer interface [polypeptide binding]; other site 273123003841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 273123003842 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 273123003843 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 273123003844 DNA binding site [nucleotide binding] 273123003845 active site 273123003846 gene expression modulator; Provisional; Region: PRK10945 273123003847 Hha toxicity attenuator; Provisional; Region: PRK10667 273123003848 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 273123003849 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 273123003850 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 273123003851 Protein export membrane protein; Region: SecD_SecF; cl14618 273123003852 11 probable transmembrane helices predicted by TMHMM2.0 273123003853 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 273123003854 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123003855 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123003856 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 273123003857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 273123003858 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 273123003859 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 273123003860 hypothetical protein; Provisional; Region: PRK11281 273123003861 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 273123003862 Mechanosensitive ion channel; Region: MS_channel; pfam00924 273123003863 12 probable transmembrane helices predicted by TMHMM2.0 273123003864 hypothetical protein; Provisional; Region: PRK11038 273123003865 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 273123003866 hypothetical protein; Provisional; Region: PRK10527 273123003867 3 probable transmembrane helices predicted by TMHMM2.0 273123003868 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273123003869 active site 273123003870 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 273123003871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123003872 Walker A motif; other site 273123003873 ATP binding site [chemical binding]; other site 273123003874 Walker B motif; other site 273123003875 arginine finger; other site 273123003876 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 273123003877 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 273123003878 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 273123003879 hypothetical protein; Validated; Region: PRK00153 273123003880 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 273123003881 RecR protein; Region: RecR; pfam02132 273123003882 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 273123003883 putative active site [active] 273123003884 putative metal-binding site [ion binding]; other site 273123003885 tetramer interface [polypeptide binding]; other site 273123003886 heat shock protein 90; Provisional; Region: PRK05218 273123003887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123003888 ATP binding site [chemical binding]; other site 273123003889 Mg2+ binding site [ion binding]; other site 273123003890 G-X-G motif; other site 273123003891 adenylate kinase; Reviewed; Region: adk; PRK00279 273123003892 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 273123003893 AMP-binding site [chemical binding]; other site 273123003894 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 273123003895 ferrochelatase; Reviewed; Region: hemH; PRK00035 273123003896 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 273123003897 C-terminal domain interface [polypeptide binding]; other site 273123003898 active site 273123003899 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 273123003900 active site 273123003901 N-terminal domain interface [polypeptide binding]; other site 273123003902 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 273123003903 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 273123003904 catalytic loop [active] 273123003905 iron binding site [ion binding]; other site 273123003906 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 273123003907 FAD binding pocket [chemical binding]; other site 273123003908 FAD binding motif [chemical binding]; other site 273123003909 phosphate binding motif [ion binding]; other site 273123003910 beta-alpha-beta structure motif; other site 273123003911 NAD binding pocket [chemical binding]; other site 273123003912 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 273123003913 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 273123003914 substrate binding site; other site 273123003915 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 273123003916 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 273123003917 NAD binding site [chemical binding]; other site 273123003918 homotetramer interface [polypeptide binding]; other site 273123003919 homodimer interface [polypeptide binding]; other site 273123003920 substrate binding site [chemical binding]; other site 273123003921 active site 273123003922 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 273123003923 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 273123003924 inhibitor-cofactor binding pocket; inhibition site 273123003925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123003926 catalytic residue [active] 273123003927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273123003928 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 273123003929 NAD(P) binding site [chemical binding]; other site 273123003930 active site 273123003931 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273123003932 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 273123003933 12 probable transmembrane helices predicted by TMHMM2.0 273123003934 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 273123003935 active site 273123003936 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 273123003937 8 probable transmembrane helices predicted by TMHMM2.0 273123003938 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 273123003939 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 273123003940 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 273123003941 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 273123003942 NADP-binding site; other site 273123003943 homotetramer interface [polypeptide binding]; other site 273123003944 substrate binding site [chemical binding]; other site 273123003945 homodimer interface [polypeptide binding]; other site 273123003946 active site 273123003947 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 273123003948 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 273123003949 NADP binding site [chemical binding]; other site 273123003950 active site 273123003951 putative substrate binding site [chemical binding]; other site 273123003952 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 273123003953 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 273123003954 Substrate binding site; other site 273123003955 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 273123003956 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 273123003957 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 273123003958 metal-binding site 273123003959 phosphomannomutase CpsG; Provisional; Region: PRK15414 273123003960 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 273123003961 active site 273123003962 substrate binding site [chemical binding]; other site 273123003963 metal binding site [ion binding]; metal-binding site 273123003964 LPS O-antigen length regulator; Provisional; Region: PRK10381 273123003965 Chain length determinant protein; Region: Wzz; pfam02706 273123003966 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 273123003967 2 probable transmembrane helices predicted by TMHMM2.0 273123003968 inosine/guanosine kinase; Provisional; Region: PRK15074 273123003969 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 273123003970 substrate binding site [chemical binding]; other site 273123003971 ATP binding site [chemical binding]; other site 273123003972 putative cation:proton antiport protein; Provisional; Region: PRK10669 273123003973 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 273123003974 TrkA-N domain; Region: TrkA_N; pfam02254 273123003975 12 probable transmembrane helices predicted by TMHMM2.0 273123003976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123003977 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273123003978 putative substrate translocation pore; other site 273123003979 10 probable transmembrane helices predicted by TMHMM2.0 273123003980 similar to Escherichia coli ECs0533 5'-nucleotidase / UDP-sugar diphosphatase (79.8% evalue=1.E-149); Escherichia coli Z0599 ushA; 5'-nucleotidase / UDP-sugar diphosphatase (79.8% evalue=1.E-149). similar to EC 3.1.3.5.;5'-nucleotidase/UDP-sugar diphosphatase: pseudogene-frameshift 273123003981 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 273123003982 putative deacylase active site [active] 273123003983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 273123003984 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 273123003985 metal-binding site [ion binding] 273123003986 copper exporting ATPase; Provisional; Region: copA; PRK10671 273123003987 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 273123003988 metal-binding site [ion binding] 273123003989 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 273123003990 metal-binding site [ion binding] 273123003991 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273123003992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123003993 motif II; other site 273123003994 8 probable transmembrane helices predicted by TMHMM2.0 273123003995 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 273123003996 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 273123003997 DNA binding residues [nucleotide binding] 273123003998 dimer interface [polypeptide binding]; other site 273123003999 copper binding site [ion binding]; other site 273123004000 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 273123004001 3 probable transmembrane helices predicted by TMHMM2.0 273123004002 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 273123004003 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 273123004004 1 probable transmembrane helix predicted by TMHMM2.0 273123004005 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 273123004006 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 273123004007 oxidoreductase; Provisional; Region: PRK08017 273123004008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273123004009 NAD(P) binding site [chemical binding]; other site 273123004010 active site 273123004011 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 273123004012 active site 273123004013 catalytic triad [active] 273123004014 oxyanion hole [active] 273123004015 switch loop; other site 273123004016 1 probable transmembrane helix predicted by TMHMM2.0 273123004017 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 273123004018 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273123004019 Walker A/P-loop; other site 273123004020 ATP binding site [chemical binding]; other site 273123004021 Q-loop/lid; other site 273123004022 ABC transporter signature motif; other site 273123004023 Walker B; other site 273123004024 D-loop; other site 273123004025 H-loop/switch region; other site 273123004026 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 273123004027 FtsX-like permease family; Region: FtsX; pfam02687 273123004028 10 probable transmembrane helices predicted by TMHMM2.0 273123004029 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 273123004030 ATP-grasp domain; Region: ATP-grasp; pfam02222 273123004031 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 273123004032 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 273123004033 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 273123004034 putative active site [active] 273123004035 putative metal binding site [ion binding]; other site 273123004036 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 273123004037 substrate binding site [chemical binding]; other site 273123004038 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 273123004039 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 273123004040 active site 273123004041 HIGH motif; other site 273123004042 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 273123004043 KMSKS motif; other site 273123004044 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 273123004045 tRNA binding surface [nucleotide binding]; other site 273123004046 anticodon binding site; other site 273123004047 ribosome-associated protein; Provisional; Region: PRK11507 273123004048 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 273123004049 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 273123004050 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 273123004051 homodimer interface [polypeptide binding]; other site 273123004052 NADP binding site [chemical binding]; other site 273123004053 substrate binding site [chemical binding]; other site 273123004054 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 273123004055 similar to Yersinia pestis YPO2819 int; phage integrase (partial) (100% evalue=2.E-53); Escherichia coli ECs0271 integrase (67.7% evalue=5.E-33);phage integrase (partial) 273123004056 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 273123004057 3 probable transmembrane helices predicted by TMHMM2.0 273123004058 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 273123004059 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 273123004060 7 probable transmembrane helices predicted by TMHMM2.0 273123004061 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 273123004062 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 273123004063 putative acyl-acceptor binding pocket; other site 273123004064 1 probable transmembrane helix predicted by TMHMM2.0 273123004065 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 273123004066 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 273123004067 Putative methyltransferase; Region: Methyltransf_20; pfam12147 273123004068 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 273123004069 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 273123004070 active site 273123004071 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 273123004072 active site 273123004073 catalytic residues [active] 273123004074 7 probable transmembrane helices predicted by TMHMM2.0 273123004075 2 probable transmembrane helices predicted by TMHMM2.0 273123004076 1 probable transmembrane helix predicted by TMHMM2.0 273123004077 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123004078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123004079 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 273123004080 putative effector binding pocket; other site 273123004081 putative dimerization interface [polypeptide binding]; other site 273123004082 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273123004083 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273123004084 active site 273123004085 catalytic tetrad [active] 273123004086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273123004087 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273123004088 active site 273123004089 catalytic tetrad [active] 273123004090 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 273123004091 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 273123004092 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 273123004093 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 273123004094 1 probable transmembrane helix predicted by TMHMM2.0 273123004095 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 273123004096 Predicted membrane protein [Function unknown]; Region: COG4984 273123004097 21 probable transmembrane helices predicted by TMHMM2.0 273123004098 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 273123004099 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273123004100 RNA binding surface [nucleotide binding]; other site 273123004101 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 273123004102 probable active site [active] 273123004103 Uncharacterized conserved protein [Function unknown]; Region: COG2850 273123004104 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 273123004105 similar to Yersinia pestis YPO2797 hypothetical protein (96.8% evalue=3.E-45);hypothetical protein (pseudogene) 273123004106 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 273123004107 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 273123004108 Autotransporter beta-domain; Region: Autotransporter; pfam03797 273123004109 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 273123004110 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 273123004111 3 probable transmembrane helices predicted by TMHMM2.0 273123004112 1 probable transmembrane helix predicted by TMHMM2.0 273123004113 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 273123004114 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 273123004115 Transglycosylase; Region: Transgly; pfam00912 273123004116 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 273123004117 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 273123004118 1 probable transmembrane helix predicted by TMHMM2.0 273123004119 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 273123004120 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 273123004121 MG2 domain; Region: A2M_N; pfam01835 273123004122 Alpha-2-macroglobulin family; Region: A2M; pfam00207 273123004123 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 273123004124 surface patch; other site 273123004125 thioester region; other site 273123004126 specificity defining residues; other site 273123004127 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273123004128 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273123004129 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273123004130 putative active site [active] 273123004131 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 273123004132 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 273123004133 tetrameric interface [polypeptide binding]; other site 273123004134 NAD binding site [chemical binding]; other site 273123004135 catalytic residues [active] 273123004136 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 273123004137 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 273123004138 PYR/PP interface [polypeptide binding]; other site 273123004139 dimer interface [polypeptide binding]; other site 273123004140 TPP binding site [chemical binding]; other site 273123004141 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 273123004142 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 273123004143 TPP-binding site; other site 273123004144 1 probable transmembrane helix predicted by TMHMM2.0 273123004145 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273123004146 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 273123004147 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 273123004148 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 273123004149 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 273123004150 ligand binding site [chemical binding]; other site 273123004151 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123004152 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123004153 Walker A/P-loop; other site 273123004154 ATP binding site [chemical binding]; other site 273123004155 Q-loop/lid; other site 273123004156 ABC transporter signature motif; other site 273123004157 Walker B; other site 273123004158 D-loop; other site 273123004159 H-loop/switch region; other site 273123004160 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123004161 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123004162 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123004163 TM-ABC transporter signature motif; other site 273123004164 9 probable transmembrane helices predicted by TMHMM2.0 273123004165 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273123004166 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 273123004167 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 273123004168 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 273123004169 substrate binding site [chemical binding]; other site 273123004170 ATP binding site [chemical binding]; other site 273123004171 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 273123004172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 273123004173 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 273123004174 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 273123004175 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273123004176 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 273123004177 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 273123004178 Walker A/P-loop; other site 273123004179 ATP binding site [chemical binding]; other site 273123004180 Q-loop/lid; other site 273123004181 ABC transporter signature motif; other site 273123004182 Walker B; other site 273123004183 D-loop; other site 273123004184 H-loop/switch region; other site 273123004185 5 probable transmembrane helices predicted by TMHMM2.0 273123004186 Uncharacterized conserved protein [Function unknown]; Region: COG1359 273123004187 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 273123004188 9 probable transmembrane helices predicted by TMHMM2.0 273123004189 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 273123004190 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123004191 DNA binding residues [nucleotide binding] 273123004192 dimerization interface [polypeptide binding]; other site 273123004193 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273123004194 DNA-binding site [nucleotide binding]; DNA binding site 273123004195 RNA-binding motif; other site 273123004196 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273123004197 DNA-binding site [nucleotide binding]; DNA binding site 273123004198 RNA-binding motif; other site 273123004199 chromosome condensation membrane protein; Provisional; Region: PRK14196 273123004200 4 probable transmembrane helices predicted by TMHMM2.0 273123004201 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 273123004202 1 probable transmembrane helix predicted by TMHMM2.0 273123004203 lipoyl synthase; Provisional; Region: PRK05481 273123004204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123004205 FeS/SAM binding site; other site 273123004206 lipoate-protein ligase B; Provisional; Region: PRK14342 273123004207 hypothetical protein; Provisional; Region: PRK04998 273123004208 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 273123004209 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 273123004210 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 273123004211 rare lipoprotein A; Provisional; Region: PRK10672 273123004212 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 273123004213 Sporulation related domain; Region: SPOR; pfam05036 273123004214 cell wall shape-determining protein; Provisional; Region: PRK10794 273123004215 9 probable transmembrane helices predicted by TMHMM2.0 273123004216 penicillin-binding protein 2; Provisional; Region: PRK10795 273123004217 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 273123004218 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 273123004219 1 probable transmembrane helix predicted by TMHMM2.0 273123004220 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 273123004221 ribosome-associated protein; Provisional; Region: PRK11538 273123004222 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 273123004223 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 273123004224 active site 273123004225 (T/H)XGH motif; other site 273123004226 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 273123004227 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 273123004228 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 273123004229 1 probable transmembrane helix predicted by TMHMM2.0 273123004230 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 273123004231 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 273123004232 HIGH motif; other site 273123004233 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 273123004234 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 273123004235 active site 273123004236 KMSKS motif; other site 273123004237 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 273123004238 tRNA binding surface [nucleotide binding]; other site 273123004239 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 273123004240 hypothetical protein; Provisional; Region: PRK11032 273123004241 Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488 273123004242 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 273123004243 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 273123004244 Walker A/P-loop; other site 273123004245 ATP binding site [chemical binding]; other site 273123004246 Q-loop/lid; other site 273123004247 ABC transporter signature motif; other site 273123004248 Walker B; other site 273123004249 D-loop; other site 273123004250 H-loop/switch region; other site 273123004251 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 273123004252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123004253 dimer interface [polypeptide binding]; other site 273123004254 conserved gate region; other site 273123004255 putative PBP binding loops; other site 273123004256 ABC-ATPase subunit interface; other site 273123004257 5 probable transmembrane helices predicted by TMHMM2.0 273123004258 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 273123004259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123004260 dimer interface [polypeptide binding]; other site 273123004261 conserved gate region; other site 273123004262 putative PBP binding loops; other site 273123004263 ABC-ATPase subunit interface; other site 273123004264 5 probable transmembrane helices predicted by TMHMM2.0 273123004265 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 273123004266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123004267 substrate binding pocket [chemical binding]; other site 273123004268 membrane-bound complex binding site; other site 273123004269 hinge residues; other site 273123004270 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 273123004271 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 273123004272 putative active site [active] 273123004273 catalytic triad [active] 273123004274 putative dimer interface [polypeptide binding]; other site 273123004275 8 probable transmembrane helices predicted by TMHMM2.0 273123004276 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 273123004277 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 273123004278 Transporter associated domain; Region: CorC_HlyC; smart01091 273123004279 metal-binding heat shock protein; Provisional; Region: PRK00016 273123004280 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 273123004281 PhoH-like protein; Region: PhoH; pfam02562 273123004282 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 273123004283 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 273123004284 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123004285 FeS/SAM binding site; other site 273123004286 TRAM domain; Region: TRAM; pfam01938 273123004287 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 273123004288 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 273123004289 1 probable transmembrane helix predicted by TMHMM2.0 273123004290 asparagine synthetase B; Provisional; Region: asnB; PRK09431 273123004291 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 273123004292 active site 273123004293 dimer interface [polypeptide binding]; other site 273123004294 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 273123004295 Ligand Binding Site [chemical binding]; other site 273123004296 Molecular Tunnel; other site 273123004297 UMP phosphatase; Provisional; Region: PRK10444 273123004298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123004299 active site 273123004300 motif I; other site 273123004301 motif II; other site 273123004302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123004303 MarR family; Region: MarR; pfam01047 273123004304 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 273123004305 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 273123004306 nucleotide binding site [chemical binding]; other site 273123004307 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 273123004308 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 273123004309 active site 273123004310 dimer interface [polypeptide binding]; other site 273123004311 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 273123004312 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 273123004313 active site 273123004314 trimer interface [polypeptide binding]; other site 273123004315 allosteric site; other site 273123004316 active site lid [active] 273123004317 hexamer (dimer of trimers) interface [polypeptide binding]; other site 273123004318 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 273123004319 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 273123004320 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 273123004321 active site turn [active] 273123004322 phosphorylation site [posttranslational modification] 273123004323 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 273123004324 HPr interaction site; other site 273123004325 glycerol kinase (GK) interaction site [polypeptide binding]; other site 273123004326 active site 273123004327 phosphorylation site [posttranslational modification] 273123004328 9 probable transmembrane helices predicted by TMHMM2.0 273123004329 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 273123004330 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 273123004331 active site 273123004332 HIGH motif; other site 273123004333 nucleotide binding site [chemical binding]; other site 273123004334 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 273123004335 KMSKS motif; other site 273123004336 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 273123004337 outer membrane porin, OprD family; Region: OprD; pfam03573 273123004338 1 probable transmembrane helix predicted by TMHMM2.0 273123004339 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 273123004340 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 273123004341 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 273123004342 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 273123004343 active site 273123004344 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 273123004345 ferric uptake regulator; Provisional; Region: fur; PRK09462 273123004346 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 273123004347 metal binding site 2 [ion binding]; metal-binding site 273123004348 putative DNA binding helix; other site 273123004349 metal binding site 1 [ion binding]; metal-binding site 273123004350 dimer interface [polypeptide binding]; other site 273123004351 structural Zn2+ binding site [ion binding]; other site 273123004352 flavodoxin FldA; Validated; Region: PRK09267 273123004353 LexA regulated protein; Provisional; Region: PRK11675 273123004354 acyl-CoA esterase; Provisional; Region: PRK10673 273123004355 PGAP1-like protein; Region: PGAP1; pfam07819 273123004356 similar to Yersinia pestis YPO3438 intB; integrase (66.6% evalue=2.E-17);integrase (partial) 273123004357 Transposase; Region: HTH_Tnp_1; pfam01527 273123004358 similar to Yersinia pestis YPO2641 intA, slpA, intX; phage family integrase (partial) (98.4% evalue=1.E-29);phage family integrase, pseudogene-interrupted by IS100 273123004360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 273123004361 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 273123004362 DNA-binding interface [nucleotide binding]; DNA binding site 273123004363 Integrase core domain; Region: rve; pfam00665 273123004364 transposase/IS protein; Provisional; Region: PRK09183 273123004365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123004366 Walker A motif; other site 273123004367 ATP binding site [chemical binding]; other site 273123004368 Walker B motif; other site 273123004369 similar to Yersinia pestis YPO2641 intA, slpA, intX; phage family integrase (partial) (97.5% evalue=3.E-37); prophage integrase, pseudogene-interrupted by IS100 273123004370 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 273123004371 SmpB-tmRNA interface; other site 273123004372 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 273123004373 putative coenzyme Q binding site [chemical binding]; other site 273123004374 hypothetical protein; Validated; Region: PRK01777 273123004375 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 273123004376 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 273123004377 recombination and repair protein; Provisional; Region: PRK10869 273123004378 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 273123004379 Walker A/P-loop; other site 273123004380 ATP binding site [chemical binding]; other site 273123004381 Q-loop/lid; other site 273123004382 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 273123004383 Q-loop/lid; other site 273123004384 ABC transporter signature motif; other site 273123004385 Walker B; other site 273123004386 D-loop; other site 273123004387 H-loop/switch region; other site 273123004388 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 273123004389 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 273123004390 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 273123004391 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 273123004392 dimer interface [polypeptide binding]; other site 273123004393 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 273123004394 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 273123004395 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 273123004396 dimer interface [polypeptide binding]; other site 273123004397 active site 273123004398 citrylCoA binding site [chemical binding]; other site 273123004399 NADH binding [chemical binding]; other site 273123004400 cationic pore residues; other site 273123004401 oxalacetate/citrate binding site [chemical binding]; other site 273123004402 coenzyme A binding site [chemical binding]; other site 273123004403 catalytic triad [active] 273123004404 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 273123004405 Iron-sulfur protein interface; other site 273123004406 proximal quinone binding site [chemical binding]; other site 273123004407 SdhD (CybS) interface [polypeptide binding]; other site 273123004408 proximal heme binding site [chemical binding]; other site 273123004409 3 probable transmembrane helices predicted by TMHMM2.0 273123004410 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 273123004411 SdhC subunit interface [polypeptide binding]; other site 273123004412 proximal heme binding site [chemical binding]; other site 273123004413 cardiolipin binding site; other site 273123004414 Iron-sulfur protein interface; other site 273123004415 proximal quinone binding site [chemical binding]; other site 273123004416 3 probable transmembrane helices predicted by TMHMM2.0 273123004417 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 273123004418 L-aspartate oxidase; Provisional; Region: PRK06175 273123004419 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 273123004420 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 273123004421 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 273123004422 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 273123004423 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 273123004424 TPP-binding site [chemical binding]; other site 273123004425 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 273123004426 dimer interface [polypeptide binding]; other site 273123004427 PYR/PP interface [polypeptide binding]; other site 273123004428 TPP binding site [chemical binding]; other site 273123004429 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 273123004430 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 273123004431 E3 interaction surface; other site 273123004432 lipoyl attachment site [posttranslational modification]; other site 273123004433 e3 binding domain; Region: E3_binding; pfam02817 273123004434 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 273123004435 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 273123004436 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 273123004437 CoA-ligase; Region: Ligase_CoA; pfam00549 273123004438 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 273123004439 CoA binding domain; Region: CoA_binding; smart00881 273123004440 CoA-ligase; Region: Ligase_CoA; pfam00549 273123004441 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 273123004442 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 273123004443 9 probable transmembrane helices predicted by TMHMM2.0 273123004444 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 273123004445 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 273123004446 8 probable transmembrane helices predicted by TMHMM2.0 273123004447 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 273123004448 1 probable transmembrane helix predicted by TMHMM2.0 273123004449 hypothetical protein; Provisional; Region: PRK10588 273123004450 3 probable transmembrane helices predicted by TMHMM2.0 273123004451 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 273123004452 active site 273123004453 colicin uptake protein TolQ; Provisional; Region: PRK10801 273123004454 3 probable transmembrane helices predicted by TMHMM2.0 273123004455 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 273123004456 colicin uptake protein TolR; Provisional; Region: PRK11024 273123004457 1 probable transmembrane helix predicted by TMHMM2.0 273123004458 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 273123004459 TolA C-terminal; Region: TolA; pfam06519 273123004460 1 probable transmembrane helix predicted by TMHMM2.0 273123004461 translocation protein TolB; Provisional; Region: tolB; PRK03629 273123004462 TolB amino-terminal domain; Region: TolB_N; pfam04052 273123004463 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 273123004464 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 273123004465 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 273123004466 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 273123004467 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 273123004468 ligand binding site [chemical binding]; other site 273123004469 tol-pal system protein YbgF; Provisional; Region: PRK10803 273123004470 Tetratricopeptide repeat; Region: TPR_6; pfam13174 273123004471 quinolinate synthetase; Provisional; Region: PRK09375 273123004472 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 273123004473 7 probable transmembrane helices predicted by TMHMM2.0 273123004474 zinc transporter ZitB; Provisional; Region: PRK03557 273123004475 6 probable transmembrane helices predicted by TMHMM2.0 273123004476 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 273123004477 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 273123004478 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 273123004479 catalytic core [active] 273123004480 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 273123004481 psiF repeat; Region: PsiF_repeat; pfam07769 273123004482 psiF repeat; Region: PsiF_repeat; pfam07769 273123004483 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 273123004484 active site 273123004485 catalytic residues [active] 273123004486 galactokinase; Provisional; Region: PRK05101 273123004487 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 273123004488 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 273123004489 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 273123004490 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 273123004491 dimer interface [polypeptide binding]; other site 273123004492 active site 273123004493 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 273123004494 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 273123004495 NAD binding site [chemical binding]; other site 273123004496 homodimer interface [polypeptide binding]; other site 273123004497 active site 273123004498 substrate binding site [chemical binding]; other site 273123004499 CAAX protease self-immunity; Region: Abi; pfam02517 273123004500 9 probable transmembrane helices predicted by TMHMM2.0 273123004501 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 273123004502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123004503 Walker A/P-loop; other site 273123004504 ATP binding site [chemical binding]; other site 273123004505 ABC transporter signature motif; other site 273123004506 Walker B; other site 273123004507 D-loop; other site 273123004508 H-loop/switch region; other site 273123004509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123004510 Walker A/P-loop; other site 273123004511 ATP binding site [chemical binding]; other site 273123004512 Q-loop/lid; other site 273123004513 ABC transporter signature motif; other site 273123004514 Walker B; other site 273123004515 D-loop; other site 273123004516 H-loop/switch region; other site 273123004517 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 273123004518 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 273123004519 molybdenum-pterin binding domain; Region: Mop; TIGR00638 273123004520 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 273123004521 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 273123004522 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 273123004523 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 273123004524 1 probable transmembrane helix predicted by TMHMM2.0 273123004525 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 273123004526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123004527 dimer interface [polypeptide binding]; other site 273123004528 conserved gate region; other site 273123004529 putative PBP binding loops; other site 273123004530 ABC-ATPase subunit interface; other site 273123004531 5 probable transmembrane helices predicted by TMHMM2.0 273123004532 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 273123004533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123004534 Walker A/P-loop; other site 273123004535 ATP binding site [chemical binding]; other site 273123004536 Q-loop/lid; other site 273123004537 ABC transporter signature motif; other site 273123004538 Walker B; other site 273123004539 D-loop; other site 273123004540 H-loop/switch region; other site 273123004541 molybdenum-pterin binding domain; Region: Mop; TIGR00638 273123004542 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 273123004543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123004544 active site 273123004545 motif I; other site 273123004546 motif II; other site 273123004547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123004548 6-phosphogluconolactonase; Provisional; Region: PRK11028 273123004549 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 273123004550 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 273123004551 inhibitor-cofactor binding pocket; inhibition site 273123004552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123004553 catalytic residue [active] 273123004554 biotin synthase; Provisional; Region: PRK15108 273123004555 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123004556 FeS/SAM binding site; other site 273123004557 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 273123004558 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 273123004559 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 273123004560 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123004561 catalytic residue [active] 273123004562 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 273123004563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123004564 S-adenosylmethionine binding site [chemical binding]; other site 273123004565 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 273123004566 AAA domain; Region: AAA_26; pfam13500 273123004567 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 273123004568 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 273123004569 Walker A/P-loop; other site 273123004570 ATP binding site [chemical binding]; other site 273123004571 Q-loop/lid; other site 273123004572 ABC transporter signature motif; other site 273123004573 Walker B; other site 273123004574 D-loop; other site 273123004575 H-loop/switch region; other site 273123004576 excinuclease ABC subunit B; Provisional; Region: PRK05298 273123004577 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 273123004578 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273123004579 ATP-binding site [chemical binding]; other site 273123004580 ATP binding site [chemical binding]; other site 273123004581 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123004582 nucleotide binding region [chemical binding]; other site 273123004583 ATP-binding site [chemical binding]; other site 273123004584 Ultra-violet resistance protein B; Region: UvrB; pfam12344 273123004585 UvrB/uvrC motif; Region: UVR; pfam02151 273123004586 Uncharacterized conserved protein [Function unknown]; Region: COG4628 273123004587 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 273123004588 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 273123004589 phosphate binding site [ion binding]; other site 273123004590 putative substrate binding pocket [chemical binding]; other site 273123004591 dimer interface [polypeptide binding]; other site 273123004592 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 273123004593 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123004594 FeS/SAM binding site; other site 273123004595 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 273123004596 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 273123004597 trimer interface [polypeptide binding]; other site 273123004598 dimer interface [polypeptide binding]; other site 273123004599 putative active site [active] 273123004600 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 273123004601 MoaE interaction surface [polypeptide binding]; other site 273123004602 MoeB interaction surface [polypeptide binding]; other site 273123004603 thiocarboxylated glycine; other site 273123004604 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 273123004605 MoaE homodimer interface [polypeptide binding]; other site 273123004606 MoaD interaction [polypeptide binding]; other site 273123004607 active site residues [active] 273123004608 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 273123004609 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 273123004610 7 probable transmembrane helices predicted by TMHMM2.0 273123004611 choline dehydrogenase; Validated; Region: PRK02106 273123004612 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 273123004613 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 273123004614 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 273123004615 NAD(P) binding site [chemical binding]; other site 273123004616 catalytic residues [active] 273123004617 transcriptional regulator BetI; Validated; Region: PRK00767 273123004618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 273123004619 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 273123004620 choline transport protein BetT; Provisional; Region: PRK09928 273123004621 12 probable transmembrane helices predicted by TMHMM2.0 273123004622 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 273123004623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123004624 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 273123004625 putative dimerization interface [polypeptide binding]; other site 273123004626 putative substrate binding pocket [chemical binding]; other site 273123004627 EamA-like transporter family; Region: EamA; pfam00892 273123004628 10 probable transmembrane helices predicted by TMHMM2.0 273123004629 xanthosine phosphorylase; Region: XAPA; TIGR01699 273123004630 nucleoside transporter; Region: 2A0110; TIGR00889 273123004631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123004632 putative substrate translocation pore; other site 273123004633 12 probable transmembrane helices predicted by TMHMM2.0 273123004634 zinc resistance protein; Provisional; Region: zraP; PRK11546 273123004635 dimer interface [polypeptide binding]; other site 273123004636 1 probable transmembrane helix predicted by TMHMM2.0 273123004637 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 273123004638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273123004639 putative active site [active] 273123004640 heme pocket [chemical binding]; other site 273123004641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123004642 dimer interface [polypeptide binding]; other site 273123004643 phosphorylation site [posttranslational modification] 273123004644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123004645 ATP binding site [chemical binding]; other site 273123004646 Mg2+ binding site [ion binding]; other site 273123004647 G-X-G motif; other site 273123004648 2 probable transmembrane helices predicted by TMHMM2.0 273123004649 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 273123004650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123004651 active site 273123004652 phosphorylation site [posttranslational modification] 273123004653 intermolecular recognition site; other site 273123004654 dimerization interface [polypeptide binding]; other site 273123004655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123004656 Walker A motif; other site 273123004657 ATP binding site [chemical binding]; other site 273123004658 Walker B motif; other site 273123004659 arginine finger; other site 273123004660 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 273123004661 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 273123004662 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 273123004663 FMN binding site [chemical binding]; other site 273123004664 active site 273123004665 substrate binding site [chemical binding]; other site 273123004666 catalytic residue [active] 273123004667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123004668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123004669 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 273123004670 putative effector binding pocket; other site 273123004671 putative dimerization interface [polypeptide binding]; other site 273123004672 conserved hypothetical protein; Region: TIGR02118 273123004673 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 273123004674 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 273123004675 6 probable transmembrane helices predicted by TMHMM2.0 273123004676 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 273123004677 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 273123004678 6 probable transmembrane helices predicted by TMHMM2.0 273123004679 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 273123004680 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 273123004681 Walker A/P-loop; other site 273123004682 ATP binding site [chemical binding]; other site 273123004683 Q-loop/lid; other site 273123004684 ABC transporter signature motif; other site 273123004685 Walker B; other site 273123004686 D-loop; other site 273123004687 H-loop/switch region; other site 273123004688 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 273123004689 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 273123004690 Walker A/P-loop; other site 273123004691 ATP binding site [chemical binding]; other site 273123004692 Q-loop/lid; other site 273123004693 ABC transporter signature motif; other site 273123004694 Walker B; other site 273123004695 D-loop; other site 273123004696 H-loop/switch region; other site 273123004697 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 273123004698 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123004699 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123004700 1 probable transmembrane helix predicted by TMHMM2.0 273123004701 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 273123004702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 273123004703 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 273123004704 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 273123004705 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 273123004706 ATP binding site [chemical binding]; other site 273123004707 Mg++ binding site [ion binding]; other site 273123004708 motif III; other site 273123004709 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123004710 nucleotide binding region [chemical binding]; other site 273123004711 ATP-binding site [chemical binding]; other site 273123004712 Uncharacterized conserved protein [Function unknown]; Region: COG3595 273123004713 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 273123004714 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 273123004715 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 273123004716 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 273123004717 FMN binding site [chemical binding]; other site 273123004718 active site 273123004719 catalytic residues [active] 273123004720 substrate binding site [chemical binding]; other site 273123004721 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 273123004722 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 273123004723 1 probable transmembrane helix predicted by TMHMM2.0 273123004724 D-lactate dehydrogenase; Provisional; Region: PRK11183 273123004725 FAD binding domain; Region: FAD_binding_4; pfam01565 273123004726 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 273123004727 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 273123004728 putative active site [active] 273123004729 putative metal binding residues [ion binding]; other site 273123004730 signature motif; other site 273123004731 putative triphosphate binding site [ion binding]; other site 273123004732 dimer interface [polypeptide binding]; other site 273123004733 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 273123004734 active site 273123004735 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 273123004736 hypothetical protein; Provisional; Region: PRK10457 273123004737 3 probable transmembrane helices predicted by TMHMM2.0 273123004738 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 273123004739 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 273123004740 Walker A/P-loop; other site 273123004741 ATP binding site [chemical binding]; other site 273123004742 Q-loop/lid; other site 273123004743 ABC transporter signature motif; other site 273123004744 Walker B; other site 273123004745 D-loop; other site 273123004746 H-loop/switch region; other site 273123004747 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 273123004748 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 273123004749 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 273123004750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123004751 dimer interface [polypeptide binding]; other site 273123004752 conserved gate region; other site 273123004753 putative PBP binding loops; other site 273123004754 ABC-ATPase subunit interface; other site 273123004755 4 probable transmembrane helices predicted by TMHMM2.0 273123004756 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 273123004757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123004758 dimer interface [polypeptide binding]; other site 273123004759 conserved gate region; other site 273123004760 putative PBP binding loops; other site 273123004761 ABC-ATPase subunit interface; other site 273123004762 6 probable transmembrane helices predicted by TMHMM2.0 273123004763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 273123004764 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 273123004765 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 273123004766 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 273123004767 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 273123004768 putative ligand binding site [chemical binding]; other site 273123004769 1 probable transmembrane helix predicted by TMHMM2.0 273123004770 HEAT repeats; Region: HEAT_2; pfam13646 273123004771 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 273123004772 TM-ABC transporter signature motif; other site 273123004773 8 probable transmembrane helices predicted by TMHMM2.0 273123004774 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 273123004775 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 273123004776 TM-ABC transporter signature motif; other site 273123004777 10 probable transmembrane helices predicted by TMHMM2.0 273123004778 Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674 273123004779 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 273123004780 Walker A/P-loop; other site 273123004781 ATP binding site [chemical binding]; other site 273123004782 Q-loop/lid; other site 273123004783 ABC transporter signature motif; other site 273123004784 Walker B; other site 273123004785 D-loop; other site 273123004786 H-loop/switch region; other site 273123004787 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 273123004788 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 273123004789 Walker A/P-loop; other site 273123004790 ATP binding site [chemical binding]; other site 273123004791 Q-loop/lid; other site 273123004792 ABC transporter signature motif; other site 273123004793 Walker B; other site 273123004794 D-loop; other site 273123004795 H-loop/switch region; other site 273123004796 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 273123004797 tyrosine decarboxylase; Region: PLN02880 273123004798 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 273123004799 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123004800 catalytic residue [active] 273123004801 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 273123004802 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 273123004803 active site residue [active] 273123004804 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 273123004805 active site residue [active] 273123004806 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 273123004807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123004808 dimer interface [polypeptide binding]; other site 273123004809 conserved gate region; other site 273123004810 ABC-ATPase subunit interface; other site 273123004811 10 probable transmembrane helices predicted by TMHMM2.0 273123004812 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 273123004813 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 273123004814 Walker A/P-loop; other site 273123004815 ATP binding site [chemical binding]; other site 273123004816 Q-loop/lid; other site 273123004817 ABC transporter signature motif; other site 273123004818 Walker B; other site 273123004819 D-loop; other site 273123004820 H-loop/switch region; other site 273123004821 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 273123004822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123004823 putative PBP binding loops; other site 273123004824 dimer interface [polypeptide binding]; other site 273123004825 ABC-ATPase subunit interface; other site 273123004826 6 probable transmembrane helices predicted by TMHMM2.0 273123004827 arginine:agmatin antiporter; Provisional; Region: PRK10644 273123004828 12 probable transmembrane helices predicted by TMHMM2.0 273123004829 arginine decarboxylase; Provisional; Region: PRK15029 273123004830 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 273123004831 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 273123004832 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123004833 catalytic residue [active] 273123004834 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 273123004835 1 probable transmembrane helix predicted by TMHMM2.0 273123004836 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 273123004837 EamA-like transporter family; Region: EamA; pfam00892 273123004838 EamA-like transporter family; Region: EamA; pfam00892 273123004839 10 probable transmembrane helices predicted by TMHMM2.0 273123004840 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 273123004841 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 273123004842 trimer interface [polypeptide binding]; other site 273123004843 eyelet of channel; other site 273123004844 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 273123004845 DEAD_2; Region: DEAD_2; pfam06733 273123004846 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 273123004847 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 273123004848 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 273123004849 tetramer interface [polypeptide binding]; other site 273123004850 heme binding pocket [chemical binding]; other site 273123004851 NADPH binding site [chemical binding]; other site 273123004852 YfaZ precursor; Region: YfaZ; pfam07437 273123004853 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 273123004854 tyrosine transporter TyrP; Provisional; Region: PRK15132 273123004855 aromatic amino acid transport protein; Region: araaP; TIGR00837 273123004856 11 probable transmembrane helices predicted by TMHMM2.0 273123004857 hypothetical protein; Provisional; Region: PRK03673 273123004858 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 273123004859 putative MPT binding site; other site 273123004860 Competence-damaged protein; Region: CinA; cl00666 273123004861 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 273123004862 secondary substrate binding site; other site 273123004863 primary substrate binding site; other site 273123004864 inhibition loop; other site 273123004865 dimerization interface [polypeptide binding]; other site 273123004866 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 273123004867 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 273123004868 catalytic loop [active] 273123004869 iron binding site [ion binding]; other site 273123004870 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 273123004871 dimer interface [polypeptide binding]; other site 273123004872 putative radical transfer pathway; other site 273123004873 diiron center [ion binding]; other site 273123004874 tyrosyl radical; other site 273123004875 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 273123004876 ATP cone domain; Region: ATP-cone; pfam03477 273123004877 Class I ribonucleotide reductase; Region: RNR_I; cd01679 273123004878 active site 273123004879 dimer interface [polypeptide binding]; other site 273123004880 catalytic residues [active] 273123004881 effector binding site; other site 273123004882 R2 peptide binding site; other site 273123004883 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 273123004884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123004885 S-adenosylmethionine binding site [chemical binding]; other site 273123004886 DNA gyrase subunit A; Validated; Region: PRK05560 273123004887 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 273123004888 CAP-like domain; other site 273123004889 active site 273123004890 primary dimer interface [polypeptide binding]; other site 273123004891 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273123004892 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273123004893 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273123004894 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273123004895 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273123004896 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273123004897 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 273123004898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123004899 dimer interface [polypeptide binding]; other site 273123004900 phosphorylation site [posttranslational modification] 273123004901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123004902 ATP binding site [chemical binding]; other site 273123004903 Mg2+ binding site [ion binding]; other site 273123004904 G-X-G motif; other site 273123004905 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 273123004906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123004907 active site 273123004908 phosphorylation site [posttranslational modification] 273123004909 intermolecular recognition site; other site 273123004910 dimerization interface [polypeptide binding]; other site 273123004911 2 probable transmembrane helices predicted by TMHMM2.0 273123004912 transcriptional regulator RcsB; Provisional; Region: PRK10840 273123004913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123004914 active site 273123004915 phosphorylation site [posttranslational modification] 273123004916 intermolecular recognition site; other site 273123004917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123004918 DNA binding residues [nucleotide binding] 273123004919 dimerization interface [polypeptide binding]; other site 273123004920 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 273123004921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123004922 ATP binding site [chemical binding]; other site 273123004923 Mg2+ binding site [ion binding]; other site 273123004924 G-X-G motif; other site 273123004925 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 273123004926 putative binding surface; other site 273123004927 active site 273123004928 2 probable transmembrane helices predicted by TMHMM2.0 273123004929 12 probable transmembrane helices predicted by TMHMM2.0 273123004930 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 273123004931 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 273123004932 trimer interface [polypeptide binding]; other site 273123004933 eyelet of channel; other site 273123004934 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 273123004935 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 273123004936 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 273123004937 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 273123004938 12 probable transmembrane helices predicted by TMHMM2.0 273123004939 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 273123004940 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 273123004941 Cache domain; Region: Cache_1; pfam02743 273123004942 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123004943 dimerization interface [polypeptide binding]; other site 273123004944 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 273123004945 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 273123004946 dimer interface [polypeptide binding]; other site 273123004947 putative CheW interface [polypeptide binding]; other site 273123004948 2 probable transmembrane helices predicted by TMHMM2.0 273123004949 Outer membrane protease [Cell envelope biogenesis, outer membrane]; Region: OmpT; COG4571 273123004950 DinI-like family; Region: DinI; cl11630 273123004951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273123004952 non-specific DNA binding site [nucleotide binding]; other site 273123004953 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 273123004954 salt bridge; other site 273123004955 sequence-specific DNA binding site [nucleotide binding]; other site 273123004956 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 273123004957 Catalytic site [active] 273123004958 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 273123004959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 273123004960 similar to Yersinia pestis YPO1236 class II aldolase-family protein (98.6% evalue=3.E-82); Escherichia coli JW2708 ygbL; Hypothetical protein (55.7% evalue=2.E-52); class II aldolase-family protein 273123004961 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 273123004962 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 273123004963 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 273123004964 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 273123004965 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 273123004966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 273123004967 1 probable transmembrane helix predicted by TMHMM2.0 273123004968 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 273123004969 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 273123004970 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 273123004971 Phage tail tube protein; Region: Tail_tube; pfam10618 273123004972 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 273123004973 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 273123004974 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 273123004975 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 273123004976 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 273123004977 Mu-like prophage protein gp45 [Function unknown]; Region: COG4384 273123004978 Mu-like prophage protein gp46 [Function unknown]; Region: COG4381 273123004979 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 273123004980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 273123004981 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 273123004982 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273123004983 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273123004984 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273123004985 putative active site [active] 273123004986 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 273123004987 beta-galactosidase; Region: BGL; TIGR03356 273123004988 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 273123004989 similar to Yersinia pestis YPO1258 conserved hypothetical protein (83.2% evalue=1.E-124);probable remnant of prophage protein 273123004990 similar to Yersinia pestis YPO1259 bacteriophage protein (partial) (98.2% evalue=6.E-29); Escherichia coli ECs1584 hypothetical protein (63.2% evalue=7.E-15);remnant of bacteriophage protein 273123004991 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 273123004992 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 273123004993 Sulfatase; Region: Sulfatase; cl17466 273123004994 5 probable transmembrane helices predicted by TMHMM2.0 273123004995 hypothetical protein; Provisional; Region: PRK13689 273123004996 Nucleoid-associated protein [General function prediction only]; Region: COG3081 273123004997 nucleoid-associated protein NdpA; Validated; Region: PRK00378 273123004998 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 273123004999 5S rRNA interface [nucleotide binding]; other site 273123005000 CTC domain interface [polypeptide binding]; other site 273123005001 L16 interface [polypeptide binding]; other site 273123005002 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 273123005003 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273123005004 ATP binding site [chemical binding]; other site 273123005005 putative Mg++ binding site [ion binding]; other site 273123005006 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123005007 nucleotide binding region [chemical binding]; other site 273123005008 ATP-binding site [chemical binding]; other site 273123005009 Double zinc ribbon; Region: DZR; pfam12773 273123005010 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 273123005011 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273123005012 RNA binding surface [nucleotide binding]; other site 273123005013 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 273123005014 active site 273123005015 uracil binding [chemical binding]; other site 273123005016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123005017 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 273123005018 putative substrate translocation pore; other site 273123005019 12 probable transmembrane helices predicted by TMHMM2.0 273123005020 hypothetical protein; Provisional; Region: PRK11835 273123005021 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 273123005022 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123005023 Walker A/P-loop; other site 273123005024 ATP binding site [chemical binding]; other site 273123005025 Q-loop/lid; other site 273123005026 ABC transporter signature motif; other site 273123005027 Walker B; other site 273123005028 D-loop; other site 273123005029 H-loop/switch region; other site 273123005030 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273123005031 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123005032 Walker A/P-loop; other site 273123005033 ATP binding site [chemical binding]; other site 273123005034 Q-loop/lid; other site 273123005035 ABC transporter signature motif; other site 273123005036 Walker B; other site 273123005037 D-loop; other site 273123005038 H-loop/switch region; other site 273123005039 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 273123005040 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 273123005041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123005042 dimer interface [polypeptide binding]; other site 273123005043 conserved gate region; other site 273123005044 putative PBP binding loops; other site 273123005045 ABC-ATPase subunit interface; other site 273123005046 6 probable transmembrane helices predicted by TMHMM2.0 273123005047 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 273123005048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123005049 dimer interface [polypeptide binding]; other site 273123005050 conserved gate region; other site 273123005051 putative PBP binding loops; other site 273123005052 ABC-ATPase subunit interface; other site 273123005053 6 probable transmembrane helices predicted by TMHMM2.0 273123005054 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 273123005055 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 273123005056 phage resistance protein; Provisional; Region: PRK10551 273123005057 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 273123005058 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 273123005059 2 probable transmembrane helices predicted by TMHMM2.0 273123005060 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 273123005061 NlpC/P60 family; Region: NLPC_P60; pfam00877 273123005062 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 273123005063 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 273123005064 active site 273123005065 6 probable transmembrane helices predicted by TMHMM2.0 273123005066 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 273123005067 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 273123005068 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 273123005069 1 probable transmembrane helix predicted by TMHMM2.0 273123005070 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 273123005071 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123005072 DNA-binding site [nucleotide binding]; DNA binding site 273123005073 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 273123005074 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 273123005075 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 273123005076 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 273123005077 mannonate dehydratase; Provisional; Region: PRK03906 273123005078 mannonate dehydratase; Region: uxuA; TIGR00695 273123005079 elongation factor P; Provisional; Region: PRK04542 273123005080 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 273123005081 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 273123005082 RNA binding site [nucleotide binding]; other site 273123005083 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 273123005084 RNA binding site [nucleotide binding]; other site 273123005085 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 273123005086 aromatic amino acid transport protein; Region: araaP; TIGR00837 273123005087 9 probable transmembrane helices predicted by TMHMM2.0 273123005088 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 273123005089 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 273123005090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273123005091 NAD(P) binding site [chemical binding]; other site 273123005092 active site 273123005093 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 273123005094 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 273123005095 ligand binding site [chemical binding]; other site 273123005096 NAD binding site [chemical binding]; other site 273123005097 catalytic site [active] 273123005098 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 273123005099 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 273123005100 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 273123005101 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 273123005102 tetramerization interface [polypeptide binding]; other site 273123005103 NAD(P) binding site [chemical binding]; other site 273123005104 catalytic residues [active] 273123005105 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 273123005106 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 273123005107 N- and C-terminal domain interface [polypeptide binding]; other site 273123005108 active site 273123005109 MgATP binding site [chemical binding]; other site 273123005110 catalytic site [active] 273123005111 metal binding site [ion binding]; metal-binding site 273123005112 xylulose binding site [chemical binding]; other site 273123005113 homodimer interface [polypeptide binding]; other site 273123005114 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 273123005115 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273123005116 active site 273123005117 dimer interface [polypeptide binding]; other site 273123005118 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 273123005119 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 273123005120 ligand binding site [chemical binding]; other site 273123005121 1 probable transmembrane helix predicted by TMHMM2.0 273123005122 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123005123 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123005124 Walker A/P-loop; other site 273123005125 ATP binding site [chemical binding]; other site 273123005126 Q-loop/lid; other site 273123005127 ABC transporter signature motif; other site 273123005128 Walker B; other site 273123005129 D-loop; other site 273123005130 H-loop/switch region; other site 273123005131 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123005132 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123005133 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123005134 TM-ABC transporter signature motif; other site 273123005135 9 probable transmembrane helices predicted by TMHMM2.0 273123005136 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 273123005137 nudix motif; other site 273123005138 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 273123005139 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273123005140 active site 273123005141 phosphorylation site [posttranslational modification] 273123005142 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 273123005143 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 273123005144 dimerization domain swap beta strand [polypeptide binding]; other site 273123005145 regulatory protein interface [polypeptide binding]; other site 273123005146 active site 273123005147 regulatory phosphorylation site [posttranslational modification]; other site 273123005148 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 273123005149 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 273123005150 putative substrate binding site [chemical binding]; other site 273123005151 putative ATP binding site [chemical binding]; other site 273123005152 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 273123005153 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 273123005154 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 273123005155 active site 273123005156 P-loop; other site 273123005157 phosphorylation site [posttranslational modification] 273123005158 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 273123005159 9 probable transmembrane helices predicted by TMHMM2.0 273123005160 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 273123005161 DNA binding site [nucleotide binding] 273123005162 1 probable transmembrane helix predicted by TMHMM2.0 273123005163 1 probable transmembrane helix predicted by TMHMM2.0 273123005164 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 273123005165 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 273123005166 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 273123005167 1 probable transmembrane helix predicted by TMHMM2.0 273123005168 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 273123005169 PapC N-terminal domain; Region: PapC_N; pfam13954 273123005170 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 273123005171 PapC C-terminal domain; Region: PapC_C; pfam13953 273123005172 endonuclease IV; Provisional; Region: PRK01060 273123005173 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 273123005174 AP (apurinic/apyrimidinic) site pocket; other site 273123005175 DNA interaction; other site 273123005176 Metal-binding active site; metal-binding site 273123005177 Predicted membrane protein [Function unknown]; Region: COG2855 273123005178 9 probable transmembrane helices predicted by TMHMM2.0 273123005179 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 273123005180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123005181 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 273123005182 putative dimerization interface [polypeptide binding]; other site 273123005183 lysine transporter; Provisional; Region: PRK10836 273123005184 12 probable transmembrane helices predicted by TMHMM2.0 273123005185 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 273123005186 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 273123005187 putative ligand binding residues [chemical binding]; other site 273123005188 1 probable transmembrane helix predicted by TMHMM2.0 273123005189 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 273123005190 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 273123005191 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123005192 ABC-ATPase subunit interface; other site 273123005193 dimer interface [polypeptide binding]; other site 273123005194 putative PBP binding regions; other site 273123005195 9 probable transmembrane helices predicted by TMHMM2.0 273123005196 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 273123005197 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 273123005198 Walker A/P-loop; other site 273123005199 ATP binding site [chemical binding]; other site 273123005200 Q-loop/lid; other site 273123005201 ABC transporter signature motif; other site 273123005202 Walker B; other site 273123005203 D-loop; other site 273123005204 H-loop/switch region; other site 273123005205 putative outer membrane receptor; Provisional; Region: PRK13513 273123005206 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 273123005207 N-terminal plug; other site 273123005208 ligand-binding site [chemical binding]; other site 273123005209 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 273123005210 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 273123005211 putative C-terminal domain interface [polypeptide binding]; other site 273123005212 putative GSH binding site (G-site) [chemical binding]; other site 273123005213 putative dimer interface [polypeptide binding]; other site 273123005214 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 273123005215 putative N-terminal domain interface [polypeptide binding]; other site 273123005216 putative dimer interface [polypeptide binding]; other site 273123005217 putative substrate binding pocket (H-site) [chemical binding]; other site 273123005218 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 273123005219 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 273123005220 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 273123005221 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 273123005222 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 273123005223 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 273123005224 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 273123005225 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 273123005226 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 273123005227 Walker A/P-loop; other site 273123005228 ATP binding site [chemical binding]; other site 273123005229 Q-loop/lid; other site 273123005230 ABC transporter signature motif; other site 273123005231 Walker B; other site 273123005232 D-loop; other site 273123005233 H-loop/switch region; other site 273123005234 NIL domain; Region: NIL; pfam09383 273123005235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123005236 dimer interface [polypeptide binding]; other site 273123005237 conserved gate region; other site 273123005238 ABC-ATPase subunit interface; other site 273123005239 5 probable transmembrane helices predicted by TMHMM2.0 273123005240 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 273123005241 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 273123005242 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 273123005243 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 273123005244 serine transporter; Region: stp; TIGR00814 273123005245 11 probable transmembrane helices predicted by TMHMM2.0 273123005246 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 273123005247 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 273123005248 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 273123005249 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 273123005250 intersubunit interface [polypeptide binding]; other site 273123005251 active site 273123005252 catalytic residue [active] 273123005253 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 273123005254 active site 273123005255 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 273123005256 5 probable transmembrane helices predicted by TMHMM2.0 273123005257 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 273123005258 active site 273123005259 6 probable transmembrane helices predicted by TMHMM2.0 273123005260 putative transporter; Provisional; Region: PRK04972 273123005261 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 273123005262 TrkA-C domain; Region: TrkA_C; pfam02080 273123005263 TrkA-C domain; Region: TrkA_C; pfam02080 273123005264 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 273123005265 11 probable transmembrane helices predicted by TMHMM2.0 273123005266 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 273123005267 GSH binding site [chemical binding]; other site 273123005268 catalytic residues [active] 273123005269 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 273123005270 2 probable transmembrane helices predicted by TMHMM2.0 273123005271 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 273123005272 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 273123005273 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 273123005274 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 273123005275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123005276 Walker A/P-loop; other site 273123005277 ATP binding site [chemical binding]; other site 273123005278 Q-loop/lid; other site 273123005279 ABC transporter signature motif; other site 273123005280 Walker B; other site 273123005281 D-loop; other site 273123005282 H-loop/switch region; other site 273123005283 TOBE domain; Region: TOBE_2; pfam08402 273123005284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123005285 dimer interface [polypeptide binding]; other site 273123005286 conserved gate region; other site 273123005287 putative PBP binding loops; other site 273123005288 ABC-ATPase subunit interface; other site 273123005289 6 probable transmembrane helices predicted by TMHMM2.0 273123005290 similar to Yersinia pestis YPO1334 potI; putrescine transport system permease (97.5% evalue=1.E-149); Salmonella typhimurium STM0880 potI; ABC superfamily (membrane), putrescine transporter (82.5% evalue=1.E-129);ABC type putrescine/spermidine transporter, permease potI 273123005291 7 probable transmembrane helices predicted by TMHMM2.0 273123005292 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 273123005293 4 probable transmembrane helices predicted by TMHMM2.0 273123005294 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 273123005295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123005296 S-adenosylmethionine binding site [chemical binding]; other site 273123005297 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 273123005298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123005299 substrate binding pocket [chemical binding]; other site 273123005300 membrane-bound complex binding site; other site 273123005301 hinge residues; other site 273123005302 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 273123005303 SPFH domain / Band 7 family; Region: Band_7; pfam01145 273123005304 1 probable transmembrane helix predicted by TMHMM2.0 273123005305 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 273123005306 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 273123005307 putative ligand binding residues [chemical binding]; other site 273123005308 1 probable transmembrane helix predicted by TMHMM2.0 273123005309 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 273123005310 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123005311 ABC-ATPase subunit interface; other site 273123005312 dimer interface [polypeptide binding]; other site 273123005313 putative PBP binding regions; other site 273123005314 9 probable transmembrane helices predicted by TMHMM2.0 273123005315 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 273123005316 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 273123005317 Walker A/P-loop; other site 273123005318 ATP binding site [chemical binding]; other site 273123005319 Q-loop/lid; other site 273123005320 ABC transporter signature motif; other site 273123005321 Walker B; other site 273123005322 D-loop; other site 273123005323 H-loop/switch region; other site 273123005324 Nicotianamine synthase protein; Region: NAS; cl17658 273123005325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 273123005326 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 273123005327 EamA-like transporter family; Region: EamA; pfam00892 273123005328 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 273123005329 10 probable transmembrane helices predicted by TMHMM2.0 273123005330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123005331 dimer interface [polypeptide binding]; other site 273123005332 conserved gate region; other site 273123005333 putative PBP binding loops; other site 273123005334 ABC-ATPase subunit interface; other site 273123005335 5 probable transmembrane helices predicted by TMHMM2.0 273123005336 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 273123005337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123005338 dimer interface [polypeptide binding]; other site 273123005339 conserved gate region; other site 273123005340 putative PBP binding loops; other site 273123005341 ABC-ATPase subunit interface; other site 273123005342 4 probable transmembrane helices predicted by TMHMM2.0 273123005343 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 273123005344 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123005345 substrate binding pocket [chemical binding]; other site 273123005346 membrane-bound complex binding site; other site 273123005347 hinge residues; other site 273123005348 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 273123005349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123005350 Walker A/P-loop; other site 273123005351 ATP binding site [chemical binding]; other site 273123005352 Q-loop/lid; other site 273123005353 ABC transporter signature motif; other site 273123005354 Walker B; other site 273123005355 D-loop; other site 273123005356 H-loop/switch region; other site 273123005357 chorismate mutase; Provisional; Region: PRK08055 273123005358 putative lipoprotein; Provisional; Region: PRK10533 273123005359 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 273123005360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273123005361 NAD(P) binding site [chemical binding]; other site 273123005362 active site 273123005363 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 273123005364 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 273123005365 putative NAD(P) binding site [chemical binding]; other site 273123005366 putative active site [active] 273123005367 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 273123005368 1 probable transmembrane helix predicted by TMHMM2.0 273123005369 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 273123005370 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 273123005371 tetramer interface [polypeptide binding]; other site 273123005372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123005373 catalytic residue [active] 273123005374 pyruvate dehydrogenase; Provisional; Region: PRK09124 273123005375 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 273123005376 PYR/PP interface [polypeptide binding]; other site 273123005377 dimer interface [polypeptide binding]; other site 273123005378 tetramer interface [polypeptide binding]; other site 273123005379 TPP binding site [chemical binding]; other site 273123005380 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 273123005381 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 273123005382 TPP-binding site [chemical binding]; other site 273123005383 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 273123005384 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 273123005385 FAD binding pocket [chemical binding]; other site 273123005386 FAD binding motif [chemical binding]; other site 273123005387 phosphate binding motif [ion binding]; other site 273123005388 beta-alpha-beta structure motif; other site 273123005389 NAD binding pocket [chemical binding]; other site 273123005390 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 273123005391 catalytic loop [active] 273123005392 iron binding site [ion binding]; other site 273123005393 hybrid cluster protein; Provisional; Region: PRK05290 273123005394 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273123005395 ACS interaction site; other site 273123005396 CODH interaction site; other site 273123005397 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 273123005398 hybrid metal cluster; other site 273123005399 Predicted membrane protein [Function unknown]; Region: COG2431 273123005400 8 probable transmembrane helices predicted by TMHMM2.0 273123005401 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 273123005402 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 273123005403 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 273123005404 putative active site [active] 273123005405 putative metal-binding site [ion binding]; other site 273123005406 Protein of unknown function (DUF535); Region: DUF535; pfam04393 273123005407 macrolide transporter subunit MacA; Provisional; Region: PRK11578 273123005408 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123005409 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123005410 1 probable transmembrane helix predicted by TMHMM2.0 273123005411 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 273123005412 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273123005413 Walker A/P-loop; other site 273123005414 ATP binding site [chemical binding]; other site 273123005415 Q-loop/lid; other site 273123005416 ABC transporter signature motif; other site 273123005417 Walker B; other site 273123005418 D-loop; other site 273123005419 H-loop/switch region; other site 273123005420 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 273123005421 FtsX-like permease family; Region: FtsX; pfam02687 273123005422 5 probable transmembrane helices predicted by TMHMM2.0 273123005423 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273123005424 DNA-binding site [nucleotide binding]; DNA binding site 273123005425 RNA-binding motif; other site 273123005426 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 273123005427 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 273123005428 Clp amino terminal domain; Region: Clp_N; pfam02861 273123005429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123005430 Walker A motif; other site 273123005431 ATP binding site [chemical binding]; other site 273123005432 Walker B motif; other site 273123005433 arginine finger; other site 273123005434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123005435 Walker A motif; other site 273123005436 ATP binding site [chemical binding]; other site 273123005437 Walker B motif; other site 273123005438 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 273123005439 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 273123005440 rRNA binding site [nucleotide binding]; other site 273123005441 predicted 30S ribosome binding site; other site 273123005442 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 273123005443 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 273123005444 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 273123005445 Walker A/P-loop; other site 273123005446 ATP binding site [chemical binding]; other site 273123005447 Q-loop/lid; other site 273123005448 ABC transporter signature motif; other site 273123005449 Walker B; other site 273123005450 D-loop; other site 273123005451 H-loop/switch region; other site 273123005452 6 probable transmembrane helices predicted by TMHMM2.0 273123005453 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 273123005454 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273123005455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123005456 Walker A/P-loop; other site 273123005457 ATP binding site [chemical binding]; other site 273123005458 Q-loop/lid; other site 273123005459 ABC transporter signature motif; other site 273123005460 Walker B; other site 273123005461 D-loop; other site 273123005462 H-loop/switch region; other site 273123005463 6 probable transmembrane helices predicted by TMHMM2.0 273123005464 thioredoxin reductase; Provisional; Region: PRK10262 273123005465 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273123005466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273123005467 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 273123005468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273123005469 putative DNA binding site [nucleotide binding]; other site 273123005470 putative Zn2+ binding site [ion binding]; other site 273123005471 AsnC family; Region: AsnC_trans_reg; pfam01037 273123005472 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 273123005473 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 273123005474 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 273123005475 5 probable transmembrane helices predicted by TMHMM2.0 273123005476 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 273123005477 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 273123005478 recombination factor protein RarA; Reviewed; Region: PRK13342 273123005479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123005480 Walker A motif; other site 273123005481 ATP binding site [chemical binding]; other site 273123005482 Walker B motif; other site 273123005483 arginine finger; other site 273123005484 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 273123005485 seryl-tRNA synthetase; Provisional; Region: PRK05431 273123005486 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 273123005487 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 273123005488 dimer interface [polypeptide binding]; other site 273123005489 active site 273123005490 motif 1; other site 273123005491 motif 2; other site 273123005492 motif 3; other site 273123005493 putative MFS family transporter protein; Provisional; Region: PRK03633 273123005494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123005495 putative substrate translocation pore; other site 273123005496 12 probable transmembrane helices predicted by TMHMM2.0 273123005497 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 273123005498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123005499 FeS/SAM binding site; other site 273123005500 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 273123005501 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 273123005502 Pyruvate formate lyase 1; Region: PFL1; cd01678 273123005503 coenzyme A binding site [chemical binding]; other site 273123005504 active site 273123005505 catalytic residues [active] 273123005506 glycine loop; other site 273123005507 formate transporter; Provisional; Region: PRK10805 273123005508 6 probable transmembrane helices predicted by TMHMM2.0 273123005509 uncharacterized domain; Region: TIGR00702 273123005510 YcaO-like family; Region: YcaO; pfam02624 273123005511 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 273123005512 active site 273123005513 homodimer interface [polypeptide binding]; other site 273123005514 homotetramer interface [polypeptide binding]; other site 273123005515 1 probable transmembrane helix predicted by TMHMM2.0 273123005516 Haemagglutinin; Region: HIM; pfam05662 273123005517 YadA-like C-terminal region; Region: YadA; pfam03895 273123005518 YadA-like C-terminal region; Region: YadA; pfam03895 273123005519 1 probable transmembrane helix predicted by TMHMM2.0 273123005520 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 273123005521 homodimer interface [polypeptide binding]; other site 273123005522 substrate-cofactor binding pocket; other site 273123005523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123005524 catalytic residue [active] 273123005525 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 273123005526 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 273123005527 hinge; other site 273123005528 active site 273123005529 cytidylate kinase; Provisional; Region: cmk; PRK00023 273123005530 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 273123005531 CMP-binding site; other site 273123005532 The sites determining sugar specificity; other site 273123005533 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 273123005534 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 273123005535 RNA binding site [nucleotide binding]; other site 273123005536 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 273123005537 RNA binding site [nucleotide binding]; other site 273123005538 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 273123005539 RNA binding site [nucleotide binding]; other site 273123005540 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 273123005541 RNA binding site [nucleotide binding]; other site 273123005542 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 273123005543 RNA binding site [nucleotide binding]; other site 273123005544 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 273123005545 RNA binding site [nucleotide binding]; other site 273123005546 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 273123005547 IHF dimer interface [polypeptide binding]; other site 273123005548 IHF - DNA interface [nucleotide binding]; other site 273123005549 ComEC family competence protein; Provisional; Region: PRK11539 273123005550 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 273123005551 Competence protein; Region: Competence; pfam03772 273123005552 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 273123005553 10 probable transmembrane helices predicted by TMHMM2.0 273123005554 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 273123005555 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273123005556 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 273123005557 Walker A/P-loop; other site 273123005558 ATP binding site [chemical binding]; other site 273123005559 Q-loop/lid; other site 273123005560 ABC transporter signature motif; other site 273123005561 Walker B; other site 273123005562 D-loop; other site 273123005563 H-loop/switch region; other site 273123005564 6 probable transmembrane helices predicted by TMHMM2.0 273123005565 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 273123005566 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 273123005567 1 probable transmembrane helix predicted by TMHMM2.0 273123005568 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 273123005569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 273123005570 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273123005571 DNA-binding site [nucleotide binding]; DNA binding site 273123005572 RNA-binding motif; other site 273123005573 Trm112p-like protein; Region: Trm112p; cl01066 273123005574 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 273123005575 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 273123005576 Ligand binding site; other site 273123005577 oligomer interface; other site 273123005578 hypothetical protein; Provisional; Region: PRK10593 273123005579 Methyltransferase domain; Region: Methyltransf_31; pfam13847 273123005580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123005581 S-adenosylmethionine binding site [chemical binding]; other site 273123005582 condesin subunit F; Provisional; Region: PRK05260 273123005583 condesin subunit E; Provisional; Region: PRK05256 273123005584 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 273123005585 P-loop containing region of AAA domain; Region: AAA_29; cl17516 273123005586 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 273123005587 murein L,D-transpeptidase; Provisional; Region: PRK10594 273123005588 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 273123005589 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 273123005590 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 273123005591 1 probable transmembrane helix predicted by TMHMM2.0 273123005592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 273123005593 Peptidase M15; Region: Peptidase_M15_3; cl01194 273123005594 1 probable transmembrane helix predicted by TMHMM2.0 273123005595 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 273123005596 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 273123005597 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123005598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123005599 homodimer interface [polypeptide binding]; other site 273123005600 catalytic residue [active] 273123005601 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 273123005602 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 273123005603 trimer interface [polypeptide binding]; other site 273123005604 eyelet of channel; other site 273123005605 1 probable transmembrane helix predicted by TMHMM2.0 273123005606 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 273123005607 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 273123005608 putative dimer interface [polypeptide binding]; other site 273123005609 putative anticodon binding site; other site 273123005610 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 273123005611 homodimer interface [polypeptide binding]; other site 273123005612 motif 1; other site 273123005613 motif 2; other site 273123005614 active site 273123005615 motif 3; other site 273123005616 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 273123005617 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 273123005618 active site 273123005619 aminopeptidase N; Provisional; Region: pepN; PRK14015 273123005620 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 273123005621 active site 273123005622 Zn binding site [ion binding]; other site 273123005623 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 273123005624 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 273123005625 quinone interaction residues [chemical binding]; other site 273123005626 active site 273123005627 catalytic residues [active] 273123005628 FMN binding site [chemical binding]; other site 273123005629 substrate binding site [chemical binding]; other site 273123005630 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 273123005631 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 273123005632 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 273123005633 MOSC domain; Region: MOSC; pfam03473 273123005634 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 273123005635 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 273123005636 catalytic loop [active] 273123005637 iron binding site [ion binding]; other site 273123005638 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 273123005639 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 273123005640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123005641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123005642 S-adenosylmethionine binding site [chemical binding]; other site 273123005643 ABC transporter ATPase component; Reviewed; Region: PRK11147 273123005644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123005645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123005646 Walker A/P-loop; other site 273123005647 Walker A/P-loop; other site 273123005648 ATP binding site [chemical binding]; other site 273123005649 ATP binding site [chemical binding]; other site 273123005650 Q-loop/lid; other site 273123005651 Q-loop/lid; other site 273123005652 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273123005653 ABC transporter signature motif; other site 273123005654 Walker B; other site 273123005655 D-loop; other site 273123005656 ABC transporter; Region: ABC_tran_2; pfam12848 273123005657 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273123005658 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 273123005659 Paraquat-inducible protein A; Region: PqiA; pfam04403 273123005660 Paraquat-inducible protein A; Region: PqiA; pfam04403 273123005661 8 probable transmembrane helices predicted by TMHMM2.0 273123005662 paraquat-inducible protein B; Provisional; Region: PRK10807 273123005663 mce related protein; Region: MCE; pfam02470 273123005664 mce related protein; Region: MCE; pfam02470 273123005665 mce related protein; Region: MCE; pfam02470 273123005666 1 probable transmembrane helix predicted by TMHMM2.0 273123005667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 273123005668 Protein of unknown function (DUF330); Region: DUF330; pfam03886 273123005669 Ribosome modulation factor; Region: RMF; pfam04957 273123005670 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 273123005671 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 273123005672 dimer interface [polypeptide binding]; other site 273123005673 active site 273123005674 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 273123005675 active site 2 [active] 273123005676 dimer interface [polypeptide binding]; other site 273123005677 active site 1 [active] 273123005678 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 273123005679 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 273123005680 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 273123005681 outer membrane protein A; Reviewed; Region: PRK10808 273123005682 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 273123005683 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 273123005684 ligand binding site [chemical binding]; other site 273123005685 SOS-response cell division inhibitor, blocks FtsZ ring formation [Cell division and chromosome partitioning]; Region: SulA; COG5404 273123005686 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 273123005687 TfoX C-terminal domain; Region: TfoX_C; pfam04994 273123005688 1 probable transmembrane helix predicted by TMHMM2.0 273123005689 TIGR01666 family membrane protein; Region: YCCS 273123005690 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 273123005691 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 273123005692 8 probable transmembrane helices predicted by TMHMM2.0 273123005693 Predicted membrane protein [Function unknown]; Region: COG3304 273123005694 Domain of unknown function (DUF307); Region: DUF307; pfam03733 273123005695 3 probable transmembrane helices predicted by TMHMM2.0 273123005696 DNA helicase IV; Provisional; Region: helD; PRK11054 273123005697 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 273123005698 Part of AAA domain; Region: AAA_19; pfam13245 273123005699 Family description; Region: UvrD_C_2; pfam13538 273123005700 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 273123005701 active site 273123005702 dimer interfaces [polypeptide binding]; other site 273123005703 catalytic residues [active] 273123005704 hypothetical protein; Provisional; Region: PRK03641 273123005705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 273123005706 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 273123005707 heat shock protein HspQ; Provisional; Region: PRK14129 273123005708 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 273123005709 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 273123005710 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 273123005711 putative RNA binding site [nucleotide binding]; other site 273123005712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123005713 S-adenosylmethionine binding site [chemical binding]; other site 273123005714 acylphosphatase; Provisional; Region: PRK14426 273123005715 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 273123005716 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 273123005717 similar to Yersinia pestis YPCD1.10c YPCD1.10c (64% evalue=3.E-13); Xylella fastidiosa XF2303 transposase (70% evalue=4.E-14);frameshifted transposase 273123005718 pseudogene containing frameshift and nonsense mutations;cytotoxic necrotizing factor (partial) 273123005719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 273123005720 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 273123005721 FAD binding domain; Region: FAD_binding_4; pfam01565 273123005722 short chain dehydrogenase; Provisional; Region: PRK06172 273123005723 classical (c) SDRs; Region: SDR_c; cd05233 273123005724 NAD(P) binding site [chemical binding]; other site 273123005725 active site 273123005726 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 273123005727 active site 2 [active] 273123005728 active site 1 [active] 273123005729 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 273123005730 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 273123005731 dimer interface [polypeptide binding]; other site 273123005732 active site 273123005733 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 273123005734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273123005735 NAD(P) binding site [chemical binding]; other site 273123005736 active site 273123005737 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 273123005738 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 273123005739 dimer interface [polypeptide binding]; other site 273123005740 active site 273123005741 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 273123005742 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 273123005743 substrate binding site [chemical binding]; other site 273123005744 oxyanion hole (OAH) forming residues; other site 273123005745 trimer interface [polypeptide binding]; other site 273123005746 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 273123005747 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 273123005748 substrate binding site [chemical binding]; other site 273123005749 oxyanion hole (OAH) forming residues; other site 273123005750 trimer interface [polypeptide binding]; other site 273123005751 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 273123005752 classical (c) SDRs; Region: SDR_c; cd05233 273123005753 NAD(P) binding site [chemical binding]; other site 273123005754 active site 273123005755 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 273123005756 acyl carrier protein; Validated; Region: PRK07117 273123005757 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 273123005758 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 273123005759 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 273123005760 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 273123005761 Protein of unknown function (DUF877); Region: DUF877; pfam05943 273123005762 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 273123005763 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 273123005764 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 273123005765 1 probable transmembrane helix predicted by TMHMM2.0 273123005766 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 273123005767 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 273123005768 ligand binding site [chemical binding]; other site 273123005769 1 probable transmembrane helix predicted by TMHMM2.0 273123005770 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 273123005771 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 273123005772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123005773 Walker A motif; other site 273123005774 ATP binding site [chemical binding]; other site 273123005775 Walker B motif; other site 273123005776 arginine finger; other site 273123005777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123005778 Walker A motif; other site 273123005779 ATP binding site [chemical binding]; other site 273123005780 Walker B motif; other site 273123005781 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 273123005782 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 273123005783 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 273123005784 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 273123005785 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 273123005786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 273123005787 1 probable transmembrane helix predicted by TMHMM2.0 273123005788 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 273123005789 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 273123005790 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 273123005791 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 273123005792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 273123005793 virion protein; Provisional; Region: V; PHA02564 273123005794 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273123005795 TIGR02594 family protein; Region: TIGR02594 273123005796 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 273123005797 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 273123005798 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 273123005799 3 probable transmembrane helices predicted by TMHMM2.0 273123005800 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 273123005801 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 273123005802 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 273123005803 PAAR motif; Region: PAAR_motif; pfam05488 273123005804 1 probable transmembrane helix predicted by TMHMM2.0 273123005805 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 273123005806 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 273123005807 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 273123005808 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 273123005809 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 273123005810 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 273123005811 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 273123005812 ImpA domain protein; Region: DUF3702; pfam12486 273123005813 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 273123005814 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 273123005815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123005816 Walker A/P-loop; other site 273123005817 ATP binding site [chemical binding]; other site 273123005818 Q-loop/lid; other site 273123005819 ABC transporter signature motif; other site 273123005820 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273123005821 Walker B; other site 273123005822 D-loop; other site 273123005823 H-loop/switch region; other site 273123005824 ABC transporter; Region: ABC_tran_2; pfam12848 273123005825 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273123005826 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 273123005827 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 273123005828 ATP binding site [chemical binding]; other site 273123005829 substrate interface [chemical binding]; other site 273123005830 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 273123005831 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 273123005832 dimer interface [polypeptide binding]; other site 273123005833 putative functional site; other site 273123005834 putative MPT binding site; other site 273123005835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123005836 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 273123005837 FeS/SAM binding site; other site 273123005838 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 273123005839 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273123005840 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273123005841 Walker A/P-loop; other site 273123005842 ATP binding site [chemical binding]; other site 273123005843 Q-loop/lid; other site 273123005844 ABC transporter signature motif; other site 273123005845 Walker B; other site 273123005846 D-loop; other site 273123005847 H-loop/switch region; other site 273123005848 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 273123005849 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123005850 1 probable transmembrane helix predicted by TMHMM2.0 273123005851 FtsX-like permease family; Region: FtsX; pfam02687 273123005852 8 probable transmembrane helices predicted by TMHMM2.0 273123005853 S-formylglutathione hydrolase; Region: PLN02442 273123005854 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 273123005855 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 273123005856 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 273123005857 substrate binding site [chemical binding]; other site 273123005858 catalytic Zn binding site [ion binding]; other site 273123005859 NAD binding site [chemical binding]; other site 273123005860 structural Zn binding site [ion binding]; other site 273123005861 dimer interface [polypeptide binding]; other site 273123005862 1 probable transmembrane helix predicted by TMHMM2.0 273123005863 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123005864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123005865 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 273123005866 putative dimerization interface [polypeptide binding]; other site 273123005867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123005868 putative substrate translocation pore; other site 273123005869 12 probable transmembrane helices predicted by TMHMM2.0 273123005870 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 273123005871 GTP cyclohydrolase I; Provisional; Region: PLN03044 273123005872 active site 273123005873 Predicted membrane protein [Function unknown]; Region: COG2311 273123005874 hypothetical protein; Provisional; Region: PRK10835 273123005875 10 probable transmembrane helices predicted by TMHMM2.0 273123005876 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 273123005877 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 273123005878 ligand binding site [chemical binding]; other site 273123005879 calcium binding site [ion binding]; other site 273123005880 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123005881 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 273123005882 Walker A/P-loop; other site 273123005883 ATP binding site [chemical binding]; other site 273123005884 Q-loop/lid; other site 273123005885 ABC transporter signature motif; other site 273123005886 Walker B; other site 273123005887 D-loop; other site 273123005888 H-loop/switch region; other site 273123005889 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123005890 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123005891 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123005892 TM-ABC transporter signature motif; other site 273123005893 8 probable transmembrane helices predicted by TMHMM2.0 273123005894 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 273123005895 putative active site [active] 273123005896 1 probable transmembrane helix predicted by TMHMM2.0 273123005897 malate dehydrogenase; Provisional; Region: PRK13529 273123005898 Malic enzyme, N-terminal domain; Region: malic; pfam00390 273123005899 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 273123005900 NAD(P) binding site [chemical binding]; other site 273123005901 cytidine deaminase; Provisional; Region: PRK09027 273123005902 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 273123005903 active site 273123005904 catalytic motif [active] 273123005905 Zn binding site [ion binding]; other site 273123005906 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 273123005907 active site 273123005908 catalytic motif [active] 273123005909 Zn binding site [ion binding]; other site 273123005910 hypothetical protein; Provisional; Region: PRK10711 273123005911 5 probable transmembrane helices predicted by TMHMM2.0 273123005912 hypothetical protein; Provisional; Region: PRK01821 273123005913 4 probable transmembrane helices predicted by TMHMM2.0 273123005914 putative transporter; Provisional; Region: PRK10054 273123005915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123005916 putative substrate translocation pore; other site 273123005917 12 probable transmembrane helices predicted by TMHMM2.0 273123005918 Uncharacterized conserved protein [Function unknown]; Region: COG5276 273123005919 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 273123005920 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 273123005921 putative ligand binding site [chemical binding]; other site 273123005922 6 probable transmembrane helices predicted by TMHMM2.0 273123005923 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 273123005924 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 273123005925 active site 273123005926 HIGH motif; other site 273123005927 KMSKS motif; other site 273123005928 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 273123005929 tRNA binding surface [nucleotide binding]; other site 273123005930 anticodon binding site; other site 273123005931 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 273123005932 dimer interface [polypeptide binding]; other site 273123005933 putative tRNA-binding site [nucleotide binding]; other site 273123005934 antiporter inner membrane protein; Provisional; Region: PRK11670 273123005935 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 273123005936 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 273123005937 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 273123005938 ATP-binding site [chemical binding]; other site 273123005939 Sugar specificity; other site 273123005940 Pyrimidine base specificity; other site 273123005941 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 273123005942 trimer interface [polypeptide binding]; other site 273123005943 active site 273123005944 putative assembly protein; Provisional; Region: PRK10833 273123005945 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 273123005946 1 probable transmembrane helix predicted by TMHMM2.0 273123005947 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 273123005948 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 273123005949 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 273123005950 Transporter associated domain; Region: CorC_HlyC; smart01091 273123005951 6 probable transmembrane helices predicted by TMHMM2.0 273123005952 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 273123005953 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 273123005954 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 273123005955 tyrosine decarboxylase; Region: PLN02880 273123005956 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 273123005957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123005958 catalytic residue [active] 273123005959 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 273123005960 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273123005961 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 273123005962 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 273123005963 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 273123005964 IucA / IucC family; Region: IucA_IucC; pfam04183 273123005965 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 273123005966 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 273123005967 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 273123005968 Walker A/P-loop; other site 273123005969 ATP binding site [chemical binding]; other site 273123005970 Q-loop/lid; other site 273123005971 ABC transporter signature motif; other site 273123005972 Walker B; other site 273123005973 D-loop; other site 273123005974 H-loop/switch region; other site 273123005975 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 273123005976 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 273123005977 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123005978 ABC-ATPase subunit interface; other site 273123005979 dimer interface [polypeptide binding]; other site 273123005980 putative PBP binding regions; other site 273123005981 8 probable transmembrane helices predicted by TMHMM2.0 273123005982 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 273123005983 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123005984 ABC-ATPase subunit interface; other site 273123005985 dimer interface [polypeptide binding]; other site 273123005986 putative PBP binding regions; other site 273123005987 9 probable transmembrane helices predicted by TMHMM2.0 273123005988 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 273123005989 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 273123005990 siderophore binding site; other site 273123005991 1 probable transmembrane helix predicted by TMHMM2.0 273123005992 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 273123005993 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 273123005994 N-terminal plug; other site 273123005995 ligand-binding site [chemical binding]; other site 273123005996 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 273123005997 IucA / IucC family; Region: IucA_IucC; pfam04183 273123005998 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 273123005999 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 273123006000 active site 273123006001 tetramer interface; other site 273123006002 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 273123006003 active site 273123006004 tetramer interface; other site 273123006005 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 273123006006 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 273123006007 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 273123006008 Transposase IS200 like; Region: Y1_Tnp; pfam01797 273123006009 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 273123006010 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 273123006011 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 273123006012 metal binding site [ion binding]; metal-binding site 273123006013 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 273123006014 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 273123006015 substrate binding site [chemical binding]; other site 273123006016 glutamase interaction surface [polypeptide binding]; other site 273123006017 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 273123006018 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 273123006019 catalytic residues [active] 273123006020 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 273123006021 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 273123006022 putative active site [active] 273123006023 oxyanion strand; other site 273123006024 catalytic triad [active] 273123006025 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 273123006026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123006027 active site 273123006028 motif I; other site 273123006029 motif II; other site 273123006030 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 273123006031 putative active site pocket [active] 273123006032 4-fold oligomerization interface [polypeptide binding]; other site 273123006033 metal binding residues [ion binding]; metal-binding site 273123006034 3-fold/trimer interface [polypeptide binding]; other site 273123006035 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 273123006036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123006037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123006038 homodimer interface [polypeptide binding]; other site 273123006039 catalytic residue [active] 273123006040 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 273123006041 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 273123006042 NAD binding site [chemical binding]; other site 273123006043 dimerization interface [polypeptide binding]; other site 273123006044 product binding site; other site 273123006045 substrate binding site [chemical binding]; other site 273123006046 zinc binding site [ion binding]; other site 273123006047 catalytic residues [active] 273123006048 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 273123006049 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 273123006050 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 273123006051 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 273123006052 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 273123006053 putative NAD(P) binding site [chemical binding]; other site 273123006054 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123006055 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123006056 TM-ABC transporter signature motif; other site 273123006057 9 probable transmembrane helices predicted by TMHMM2.0 273123006058 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123006059 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123006060 Walker A/P-loop; other site 273123006061 ATP binding site [chemical binding]; other site 273123006062 Q-loop/lid; other site 273123006063 ABC transporter signature motif; other site 273123006064 Walker B; other site 273123006065 D-loop; other site 273123006066 H-loop/switch region; other site 273123006067 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123006068 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 273123006069 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 273123006070 putative active site [active] 273123006071 metal binding site [ion binding]; metal-binding site 273123006072 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 273123006073 12 probable transmembrane helices predicted by TMHMM2.0 273123006074 exonuclease I; Provisional; Region: sbcB; PRK11779 273123006075 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 273123006076 active site 273123006077 catalytic site [active] 273123006078 substrate binding site [chemical binding]; other site 273123006079 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 273123006080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273123006081 NAD(P) binding site [chemical binding]; other site 273123006082 active site 273123006083 hypothetical protein; Provisional; Region: PRK05423 273123006084 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 273123006085 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 273123006086 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 273123006087 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 273123006088 1 probable transmembrane helix predicted by TMHMM2.0 273123006089 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 273123006090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123006091 putative substrate translocation pore; other site 273123006092 12 probable transmembrane helices predicted by TMHMM2.0 273123006093 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 273123006094 1 probable transmembrane helix predicted by TMHMM2.0 273123006095 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 273123006096 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 273123006097 NAD binding site [chemical binding]; other site 273123006098 homotetramer interface [polypeptide binding]; other site 273123006099 homodimer interface [polypeptide binding]; other site 273123006100 active site 273123006101 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 273123006102 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 273123006103 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 273123006104 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 273123006105 putative active site pocket [active] 273123006106 metal binding site [ion binding]; metal-binding site 273123006107 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 273123006108 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 273123006109 phosphate binding site [ion binding]; other site 273123006110 argininosuccinate synthase; Validated; Region: PRK05370 273123006111 MATE family multidrug exporter; Provisional; Region: PRK10189 273123006112 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 273123006113 11 probable transmembrane helices predicted by TMHMM2.0 273123006114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123006115 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273123006116 putative substrate translocation pore; other site 273123006117 10 probable transmembrane helices predicted by TMHMM2.0 273123006118 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 273123006119 active site 273123006120 catalytic site [active] 273123006121 Zn binding site [ion binding]; other site 273123006122 tetramer interface [polypeptide binding]; other site 273123006123 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 273123006124 1 probable transmembrane helix predicted by TMHMM2.0 273123006125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 273123006127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 273123006128 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 273123006129 DNA-binding interface [nucleotide binding]; DNA binding site 273123006130 Integrase core domain; Region: rve; pfam00665 273123006131 transposase/IS protein; Provisional; Region: PRK09183 273123006132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123006133 Walker A motif; other site 273123006134 ATP binding site [chemical binding]; other site 273123006135 Walker B motif; other site 273123006136 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 273123006137 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 273123006138 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 273123006139 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 273123006140 N-terminal plug; other site 273123006141 ligand-binding site [chemical binding]; other site 273123006142 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 273123006143 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 273123006144 acyl-activating enzyme (AAE) consensus motif; other site 273123006145 active site 273123006146 AMP binding site [chemical binding]; other site 273123006147 substrate binding site [chemical binding]; other site 273123006148 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 273123006149 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 273123006150 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 273123006151 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 273123006152 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 273123006153 active site 273123006154 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 273123006155 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 273123006156 Methyltransferase domain; Region: Methyltransf_12; pfam08242 273123006157 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 273123006158 KR domain; Region: KR; pfam08659 273123006159 NADP binding site [chemical binding]; other site 273123006160 active site 273123006161 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 273123006162 Condensation domain; Region: Condensation; pfam00668 273123006163 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 273123006164 Nonribosomal peptide synthase; Region: NRPS; pfam08415 273123006165 Methyltransferase domain; Region: Methyltransf_12; pfam08242 273123006166 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 273123006167 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 273123006168 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 273123006169 Condensation domain; Region: Condensation; pfam00668 273123006170 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 273123006171 Nonribosomal peptide synthase; Region: NRPS; pfam08415 273123006172 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 273123006173 acyl-activating enzyme (AAE) consensus motif; other site 273123006174 AMP binding site [chemical binding]; other site 273123006175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123006176 S-adenosylmethionine binding site [chemical binding]; other site 273123006177 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 273123006178 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 273123006179 Condensation domain; Region: Condensation; pfam00668 273123006180 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 273123006181 Nonribosomal peptide synthase; Region: NRPS; pfam08415 273123006182 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 273123006183 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 273123006184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123006185 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273123006186 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273123006187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123006188 Walker A/P-loop; other site 273123006189 ATP binding site [chemical binding]; other site 273123006190 Q-loop/lid; other site 273123006191 ABC transporter signature motif; other site 273123006192 Walker B; other site 273123006193 D-loop; other site 273123006194 H-loop/switch region; other site 273123006195 6 probable transmembrane helices predicted by TMHMM2.0 273123006196 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273123006197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123006198 Walker A/P-loop; other site 273123006199 ATP binding site [chemical binding]; other site 273123006200 Q-loop/lid; other site 273123006201 ABC transporter signature motif; other site 273123006202 Walker B; other site 273123006203 D-loop; other site 273123006204 H-loop/switch region; other site 273123006205 5 probable transmembrane helices predicted by TMHMM2.0 273123006206 muropeptide transporter; Validated; Region: ampG; cl17669 273123006207 12 probable transmembrane helices predicted by TMHMM2.0 273123006208 salicylate synthase Irp9; Reviewed; Region: PRK06772 273123006209 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 273123006210 similar to Yersinia pestis YPO1917 int; integrase (99.5% evalue=1.E-113); Salmonella typhi STY4680 int; bacteriophage integrase (46% evalue=4.E-49);integrase pseudogene 273123006211 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 273123006212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123006213 active site 273123006214 phosphorylation site [posttranslational modification] 273123006215 intermolecular recognition site; other site 273123006216 dimerization interface [polypeptide binding]; other site 273123006217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123006218 DNA binding residues [nucleotide binding] 273123006219 dimerization interface [polypeptide binding]; other site 273123006220 DctM-like transporters; Region: DctM; pfam06808 273123006221 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 273123006222 11 probable transmembrane helices predicted by TMHMM2.0 273123006223 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 273123006224 4 probable transmembrane helices predicted by TMHMM2.0 273123006225 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 273123006226 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 273123006227 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 273123006228 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 273123006229 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 273123006230 Melibiase; Region: Melibiase; pfam02065 273123006231 galactoside permease; Reviewed; Region: lacY; PRK09528 273123006232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123006233 putative substrate translocation pore; other site 273123006234 12 probable transmembrane helices predicted by TMHMM2.0 273123006235 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273123006236 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123006237 DNA binding site [nucleotide binding] 273123006238 domain linker motif; other site 273123006239 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 273123006240 ligand binding site [chemical binding]; other site 273123006241 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 273123006242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 273123006243 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 273123006244 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 273123006245 ATP binding site [chemical binding]; other site 273123006246 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273123006247 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273123006248 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 273123006249 Walker A/P-loop; other site 273123006250 ATP binding site [chemical binding]; other site 273123006251 Q-loop/lid; other site 273123006252 ABC transporter signature motif; other site 273123006253 Walker B; other site 273123006254 D-loop; other site 273123006255 H-loop/switch region; other site 273123006256 4 probable transmembrane helices predicted by TMHMM2.0 273123006257 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 273123006258 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123006259 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 273123006260 YobH-like protein; Region: YobH; pfam13996 273123006261 1 probable transmembrane helix predicted by TMHMM2.0 273123006262 YebO-like protein; Region: YebO; pfam13974 273123006263 1 probable transmembrane helix predicted by TMHMM2.0 273123006264 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 273123006265 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 273123006266 aromatic amino acid transporter; Provisional; Region: PRK10238 273123006267 12 probable transmembrane helices predicted by TMHMM2.0 273123006268 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 273123006269 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 273123006270 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273123006271 DNA-binding site [nucleotide binding]; DNA binding site 273123006272 RNA-binding motif; other site 273123006273 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 273123006274 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 273123006275 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 273123006276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123006277 S-adenosylmethionine binding site [chemical binding]; other site 273123006278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273123006279 PAS domain; Region: PAS_9; pfam13426 273123006280 putative active site [active] 273123006281 heme pocket [chemical binding]; other site 273123006282 PAS domain S-box; Region: sensory_box; TIGR00229 273123006283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273123006284 putative active site [active] 273123006285 heme pocket [chemical binding]; other site 273123006286 PAS domain S-box; Region: sensory_box; TIGR00229 273123006287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273123006288 putative active site [active] 273123006289 heme pocket [chemical binding]; other site 273123006290 PAS fold; Region: PAS; pfam00989 273123006291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273123006292 putative active site [active] 273123006293 heme pocket [chemical binding]; other site 273123006294 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 273123006295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 273123006296 metal binding site [ion binding]; metal-binding site 273123006297 active site 273123006298 I-site; other site 273123006299 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 273123006300 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 273123006301 N-terminal plug; other site 273123006302 ligand-binding site [chemical binding]; other site 273123006303 hypothetical protein; Provisional; Region: PRK11469 273123006304 Domain of unknown function DUF; Region: DUF204; pfam02659 273123006305 Domain of unknown function DUF; Region: DUF204; pfam02659 273123006306 6 probable transmembrane helices predicted by TMHMM2.0 273123006307 hypothetical protein; Provisional; Region: PRK02913 273123006308 3 probable transmembrane helices predicted by TMHMM2.0 273123006309 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 273123006310 2 probable transmembrane helices predicted by TMHMM2.0 273123006311 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 273123006312 7 probable transmembrane helices predicted by TMHMM2.0 273123006313 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 273123006314 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 273123006315 active pocket/dimerization site; other site 273123006316 active site 273123006317 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 273123006318 active site 273123006319 phosphorylation site [posttranslational modification] 273123006320 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 273123006321 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 273123006322 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 273123006323 Transporter associated domain; Region: CorC_HlyC; smart01091 273123006324 7 probable transmembrane helices predicted by TMHMM2.0 273123006325 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 273123006326 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 273123006327 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 273123006328 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 273123006329 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 273123006330 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 273123006331 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 273123006332 NAD binding site [chemical binding]; other site 273123006333 catalytic residues [active] 273123006334 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 273123006335 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 273123006336 putative active site [active] 273123006337 putative metal binding site [ion binding]; other site 273123006338 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 273123006339 trimer interface [polypeptide binding]; other site 273123006340 putative substrate binding pocket [chemical binding]; other site 273123006341 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 273123006342 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 273123006343 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 273123006344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123006345 putative substrate translocation pore; other site 273123006346 12 probable transmembrane helices predicted by TMHMM2.0 273123006347 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 273123006348 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 273123006349 4-hydroxyphenylacetate 3-monooxygenase, reductase component; Region: HpaC; TIGR02296 273123006350 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 273123006351 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 273123006352 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 273123006353 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 273123006354 putative active site [active] 273123006355 putative CoA binding site [chemical binding]; other site 273123006356 nudix motif; other site 273123006357 metal binding site [ion binding]; metal-binding site 273123006358 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 273123006359 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 273123006360 chorismate binding enzyme; Region: Chorismate_bind; cl10555 273123006361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3140 273123006362 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 273123006363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273123006364 ATP-grasp domain; Region: ATP-grasp; pfam02222 273123006365 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 273123006366 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 273123006367 ATP binding site [chemical binding]; other site 273123006368 Mg++ binding site [ion binding]; other site 273123006369 motif III; other site 273123006370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123006371 nucleotide binding region [chemical binding]; other site 273123006372 ATP-binding site [chemical binding]; other site 273123006373 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 273123006374 YebG protein; Region: YebG; pfam07130 273123006375 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 273123006376 hypothetical protein; Provisional; Region: PRK13680 273123006377 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 273123006378 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 273123006379 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 273123006380 Serine hydrolase; Region: Ser_hydrolase; cl17834 273123006381 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 273123006382 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 273123006383 Ferritin-like domain; Region: Ferritin; pfam00210 273123006384 ferroxidase diiron center [ion binding]; other site 273123006385 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 273123006386 1 probable transmembrane helix predicted by TMHMM2.0 273123006387 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 273123006388 8 probable transmembrane helices predicted by TMHMM2.0 273123006389 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 273123006390 1 probable transmembrane helix predicted by TMHMM2.0 273123006391 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 273123006392 1 probable transmembrane helix predicted by TMHMM2.0 273123006393 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 273123006394 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 273123006395 4 probable transmembrane helices predicted by TMHMM2.0 273123006396 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 273123006397 FHIPEP family; Region: FHIPEP; pfam00771 273123006398 7 probable transmembrane helices predicted by TMHMM2.0 273123006399 Flagellar protein FlhE; Region: FlhE; pfam06366 273123006400 putative invasin; Provisional; Region: PRK10177 273123006401 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 273123006402 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 273123006403 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 273123006404 Invasin, domain 3; Region: Invasin_D3; pfam09134 273123006405 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 273123006406 1 probable transmembrane helix predicted by TMHMM2.0 273123006407 Flagellar biosynthesis/type III secretory pathway chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3418 273123006408 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 273123006409 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 273123006410 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 273123006411 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 273123006412 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 273123006413 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 273123006414 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 273123006415 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 273123006416 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 273123006417 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 273123006418 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 273123006419 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 273123006420 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 273123006421 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 273123006422 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 273123006423 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 273123006424 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 273123006425 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 273123006426 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 273123006427 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 273123006428 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 273123006429 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 273123006430 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 273123006431 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 273123006432 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 273123006433 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 273123006434 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 273123006435 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 273123006436 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 273123006437 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 273123006438 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 273123006439 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 273123006440 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 273123006441 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 273123006442 short chain dehydrogenase; Validated; Region: PRK08324 273123006443 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 273123006444 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 273123006445 putative NAD(P) binding site [chemical binding]; other site 273123006446 active site 273123006447 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123006448 TM-ABC transporter signature motif; other site 273123006449 10 probable transmembrane helices predicted by TMHMM2.0 273123006450 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 273123006451 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 273123006452 ligand binding site [chemical binding]; other site 273123006453 1 probable transmembrane helix predicted by TMHMM2.0 273123006454 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123006455 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123006456 Walker A/P-loop; other site 273123006457 ATP binding site [chemical binding]; other site 273123006458 Q-loop/lid; other site 273123006459 ABC transporter signature motif; other site 273123006460 Walker B; other site 273123006461 D-loop; other site 273123006462 H-loop/switch region; other site 273123006463 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123006464 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123006465 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123006466 TM-ABC transporter signature motif; other site 273123006467 9 probable transmembrane helices predicted by TMHMM2.0 273123006468 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 273123006469 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 273123006470 substrate binding site [chemical binding]; other site 273123006471 ATP binding site [chemical binding]; other site 273123006472 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 273123006473 6 probable transmembrane helices predicted by TMHMM2.0 273123006474 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 273123006475 2 probable transmembrane helices predicted by TMHMM2.0 273123006476 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 273123006477 5 probable transmembrane helices predicted by TMHMM2.0 273123006478 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 273123006479 1 probable transmembrane helix predicted by TMHMM2.0 273123006480 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 273123006481 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 273123006482 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 273123006483 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 273123006484 2 probable transmembrane helices predicted by TMHMM2.0 273123006485 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 273123006486 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 273123006487 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 273123006488 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 273123006489 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 273123006490 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 273123006491 Walker A motif/ATP binding site; other site 273123006492 Walker B motif; other site 273123006493 flagellar assembly protein H; Validated; Region: fliH; PRK05687 273123006494 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 273123006495 Flagellar assembly protein FliH; Region: FliH; pfam02108 273123006496 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 273123006497 FliG C-terminal domain; Region: FliG_C; pfam01706 273123006498 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 273123006499 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 273123006500 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 273123006501 1 probable transmembrane helix predicted by TMHMM2.0 273123006502 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 273123006503 similar to Yersinia pestis YPO1833 with a frameshift 273123006504 hypothetical 273123006505 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 273123006506 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 273123006507 minor groove reading motif; other site 273123006508 helix-hairpin-helix signature motif; other site 273123006509 active site 273123006510 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 273123006511 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273123006512 Zn2+ binding site [ion binding]; other site 273123006513 Mg2+ binding site [ion binding]; other site 273123006514 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273123006515 2 probable transmembrane helices predicted by TMHMM2.0 273123006516 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 273123006517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123006518 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 273123006519 flagellar protein FliS; Validated; Region: fliS; PRK05685 273123006520 flagellar capping protein; Reviewed; Region: fliD; PRK08032 273123006521 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 273123006522 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 273123006523 flagellin; Validated; Region: PRK06819 273123006524 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 273123006525 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 273123006526 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 273123006527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273123006528 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 273123006529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273123006530 DNA binding residues [nucleotide binding] 273123006531 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 273123006532 D-cysteine desulfhydrase; Validated; Region: PRK03910 273123006533 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 273123006534 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123006535 catalytic residue [active] 273123006536 cystine transporter subunit; Provisional; Region: PRK11260 273123006537 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123006538 substrate binding pocket [chemical binding]; other site 273123006539 membrane-bound complex binding site; other site 273123006540 hinge residues; other site 273123006541 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 273123006542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123006543 dimer interface [polypeptide binding]; other site 273123006544 conserved gate region; other site 273123006545 putative PBP binding loops; other site 273123006546 ABC-ATPase subunit interface; other site 273123006547 3 probable transmembrane helices predicted by TMHMM2.0 273123006548 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 273123006549 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 273123006550 Walker A/P-loop; other site 273123006551 ATP binding site [chemical binding]; other site 273123006552 Q-loop/lid; other site 273123006553 ABC transporter signature motif; other site 273123006554 Walker B; other site 273123006555 D-loop; other site 273123006556 H-loop/switch region; other site 273123006557 MarR family; Region: MarR_2; cl17246 273123006558 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 273123006559 Predicted transcriptional regulator [Transcription]; Region: COG3905 273123006560 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 273123006561 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 273123006562 Glutamate binding site [chemical binding]; other site 273123006563 NAD binding site [chemical binding]; other site 273123006564 catalytic residues [active] 273123006565 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 273123006566 Na binding site [ion binding]; other site 273123006567 12 probable transmembrane helices predicted by TMHMM2.0 273123006568 Iron permease FTR1 family; Region: FTR1; cl00475 273123006569 7 probable transmembrane helices predicted by TMHMM2.0 273123006570 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 273123006571 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 273123006572 Imelysin; Region: Peptidase_M75; pfam09375 273123006573 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 273123006574 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 273123006575 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 273123006576 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 273123006577 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 273123006578 Kelch motif; Region: Kelch_1; pfam01344 273123006579 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 273123006580 12 probable transmembrane helices predicted by TMHMM2.0 273123006581 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 273123006582 1 probable transmembrane helix predicted by TMHMM2.0 273123006583 2 probable transmembrane helices predicted by TMHMM2.0 273123006584 GlpM protein; Region: GlpM; pfam06942 273123006585 4 probable transmembrane helices predicted by TMHMM2.0 273123006586 hypothetical protein; Provisional; Region: PRK10613 273123006587 response regulator; Provisional; Region: PRK09483 273123006588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123006589 active site 273123006590 phosphorylation site [posttranslational modification] 273123006591 intermolecular recognition site; other site 273123006592 dimerization interface [polypeptide binding]; other site 273123006593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123006594 DNA binding residues [nucleotide binding] 273123006595 dimerization interface [polypeptide binding]; other site 273123006596 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 273123006597 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 273123006598 GIY-YIG motif/motif A; other site 273123006599 active site 273123006600 catalytic site [active] 273123006601 putative DNA binding site [nucleotide binding]; other site 273123006602 metal binding site [ion binding]; metal-binding site 273123006603 UvrB/uvrC motif; Region: UVR; pfam02151 273123006604 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 273123006605 Helix-hairpin-helix motif; Region: HHH; pfam00633 273123006606 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 273123006607 3 probable transmembrane helices predicted by TMHMM2.0 273123006608 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 273123006609 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 273123006610 tail protein; Provisional; Region: D; PHA02561 273123006611 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 273123006612 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 273123006613 4 probable transmembrane helices predicted by TMHMM2.0 273123006614 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 273123006615 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 273123006616 major tail tube protein; Provisional; Region: FII; PHA02600 273123006617 major tail sheath protein; Provisional; Region: FI; PHA02560 273123006618 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 273123006619 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 273123006620 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 273123006621 baseplate assembly protein; Provisional; Region: J; PHA02568 273123006622 baseplate wedge subunit; Provisional; Region: W; PHA02516 273123006623 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 273123006624 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 273123006625 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 273123006626 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 273123006627 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 273123006628 catalytic residues [active] 273123006629 2 probable transmembrane helices predicted by TMHMM2.0 273123006630 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 273123006631 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 273123006632 terminase endonuclease subunit; Provisional; Region: M; PHA02537 273123006633 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 273123006634 capsid protein; Provisional; Region: N; PHA02538 273123006635 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 273123006636 terminase ATPase subunit; Provisional; Region: P; PHA02535 273123006637 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 273123006638 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 273123006639 terminase ATPase subunit; Provisional; Region: P; PHA02535 273123006640 portal vertex protein; Provisional; Region: Q; PHA02536 273123006641 Phage portal protein; Region: Phage_portal; pfam04860 273123006642 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 273123006643 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 273123006644 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 273123006645 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 273123006646 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 273123006647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123006648 Walker A/P-loop; other site 273123006649 ATP binding site [chemical binding]; other site 273123006650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123006651 ABC transporter signature motif; other site 273123006652 Walker B; other site 273123006653 D-loop; other site 273123006654 H-loop/switch region; other site 273123006655 integrase; Provisional; Region: int; PHA02601 273123006656 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 273123006657 dimer interface [polypeptide binding]; other site 273123006658 active site 273123006659 catalytic residues [active] 273123006660 Int/Topo IB signature motif; other site 273123006661 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 273123006662 Shoulder domain; Region: MVP_shoulder; pfam11978 273123006663 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 273123006664 active site 273123006665 DNA binding site [nucleotide binding] 273123006666 Int/Topo IB signature motif; other site 273123006667 Transmembrane protein; Region: Macoilin; pfam09726 273123006668 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 273123006669 RecT family; Region: RecT; cl04285 273123006670 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 273123006671 KTSC domain; Region: KTSC; pfam13619 273123006672 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 273123006673 1 probable transmembrane helix predicted by TMHMM2.0 273123006674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273123006675 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 273123006676 non-specific DNA binding site [nucleotide binding]; other site 273123006677 salt bridge; other site 273123006678 sequence-specific DNA binding site [nucleotide binding]; other site 273123006679 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 273123006680 Catalytic site [active] 273123006681 Putative exonuclease, RdgC; Region: RdgC; pfam04381 273123006682 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 273123006683 DNA methylase; Region: N6_N4_Mtase; cl17433 273123006684 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 273123006685 DNA methylase; Region: N6_N4_Mtase; pfam01555 273123006686 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 273123006687 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 273123006688 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 273123006689 cofactor binding site; other site 273123006690 DNA binding site [nucleotide binding] 273123006691 substrate interaction site [chemical binding]; other site 273123006692 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 273123006693 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 273123006694 VRR-NUC domain; Region: VRR_NUC; pfam08774 273123006695 uncharacterized phage protein; Region: phage_xxxx; TIGR02642 273123006696 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 273123006697 Lysis protein S; Region: Lysis_S; pfam04971 273123006698 1 probable transmembrane helix predicted by TMHMM2.0 273123006699 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 273123006700 catalytic residues [active] 273123006701 1 probable transmembrane helix predicted by TMHMM2.0 273123006702 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 273123006704 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 273123006705 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 273123006706 DNA-binding interface [nucleotide binding]; DNA binding site 273123006707 Integrase core domain; Region: rve; pfam00665 273123006708 transposase/IS protein; Provisional; Region: PRK09183 273123006709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123006710 Walker A motif; other site 273123006711 ATP binding site [chemical binding]; other site 273123006712 Walker B motif; other site 273123006713 large terminase protein; Provisional; Region: 17; PHA02533 273123006714 large terminase protein; Provisional; Region: 17; PHA02533 273123006715 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 273123006716 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 273123006717 Phage Tail Collar Domain; Region: Collar; pfam07484 273123006718 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 273123006719 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 273123006720 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 273123006721 1 probable transmembrane helix predicted by TMHMM2.0 273123006722 1 probable transmembrane helix predicted by TMHMM2.0 273123006723 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 273123006724 tail protein; Provisional; Region: D; PHA02561 273123006725 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 273123006726 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 273123006727 2 probable transmembrane helices predicted by TMHMM2.0 273123006728 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 273123006729 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 273123006730 major tail tube protein; Provisional; Region: FII; PHA02600 273123006731 major tail sheath protein; Provisional; Region: FI; PHA02560 273123006732 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 273123006733 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 273123006734 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 273123006735 baseplate assembly protein; Provisional; Region: J; PHA02568 273123006736 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 273123006737 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 273123006738 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 273123006739 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 273123006740 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 273123006741 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 273123006742 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 273123006743 1 probable transmembrane helix predicted by TMHMM2.0 273123006744 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 273123006745 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 273123006746 3 probable transmembrane helices predicted by TMHMM2.0 273123006747 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 273123006748 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 273123006749 terminase endonuclease subunit; Provisional; Region: M; PHA02537 273123006750 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 273123006751 capsid protein; Provisional; Region: N; PHA02538 273123006752 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 273123006753 terminase ATPase subunit; Provisional; Region: P; PHA02535 273123006754 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 273123006755 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 273123006756 portal vertex protein; Provisional; Region: Q; PHA02536 273123006757 Phage portal protein; Region: Phage_portal; pfam04860 273123006758 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 273123006759 nucleotide sensor; other site 273123006760 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 273123006761 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 273123006762 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 273123006763 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 273123006764 active site 273123006765 catalytic site [active] 273123006766 substrate binding site [chemical binding]; other site 273123006767 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 273123006768 homodimer interface [polypeptide binding]; other site 273123006769 metal binding site [ion binding]; metal-binding site 273123006770 1 probable transmembrane helix predicted by TMHMM2.0 273123006771 Domain of unknown function (DUF2828); Region: DUF2828; pfam11443 273123006772 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 273123006773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273123006774 non-specific DNA binding site [nucleotide binding]; other site 273123006775 salt bridge; other site 273123006776 sequence-specific DNA binding site [nucleotide binding]; other site 273123006777 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 273123006778 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 273123006779 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 273123006780 1 probable transmembrane helix predicted by TMHMM2.0 273123006781 integrase; Provisional; Region: int; PHA02601 273123006782 1 probable transmembrane helix predicted by TMHMM2.0 273123006783 Sm and related proteins; Region: Sm_like; cl00259 273123006784 integrase; Provisional; Region: int; PHA02601 273123006785 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 273123006786 DNA binding site [nucleotide binding] 273123006787 Int/Topo IB signature motif; other site 273123006788 active site 273123006789 pseudogene contains frameshift, similar to Yersinia pestis YPO1868 hypothetical protein (98.8% evalue=3.E-93 location 2219889..2220401); AAN43587.1 integrase for prophage CP-933U [Shigella flexneri 2a str. (55% identity, evalue 1E-65 for the full length of the frameshift);hypothetical protein 273123006790 similar to Yersinia pestis YPO1869 replicative DNA helicase (partial) (100% evalue=3.E-37);replicative DNA helicase (partial) 273123006791 Protein of unknown function (DUF796); Region: DUF796; cl01226 273123006792 Homeodomain-like domain; Region: HTH_32; pfam13565 273123006793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 273123006794 Integrase core domain; Region: rve; pfam00665 273123006795 Integrase core domain; Region: rve_3; pfam13683 273123006796 Transposase; Region: HTH_Tnp_1; cl17663 273123006797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273123006798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123006799 putative substrate translocation pore; other site 273123006800 11 probable transmembrane helices predicted by TMHMM2.0 273123006801 hypothetical protein; Provisional; Region: PRK08328 273123006802 ThiF family; Region: ThiF; pfam00899 273123006803 ATP binding site [chemical binding]; other site 273123006804 Methyltransferase domain; Region: Methyltransf_31; pfam13847 273123006805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123006806 S-adenosylmethionine binding site [chemical binding]; other site 273123006807 Methyltransferase domain; Region: Methyltransf_23; pfam13489 273123006808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123006809 S-adenosylmethionine binding site [chemical binding]; other site 273123006810 Methyltransferase domain; Region: Methyltransf_31; pfam13847 273123006811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123006812 S-adenosylmethionine binding site [chemical binding]; other site 273123006813 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 273123006814 dimer interface [polypeptide binding]; other site 273123006815 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 273123006816 active site 273123006817 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273123006818 catalytic residues [active] 273123006819 substrate binding site [chemical binding]; other site 273123006820 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 273123006821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 273123006822 Transposase; Region: HTH_Tnp_1; pfam01527 273123006823 Homeodomain-like domain; Region: HTH_32; pfam13565 273123006824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 273123006825 Integrase core domain; Region: rve; pfam00665 273123006826 Integrase core domain; Region: rve_3; pfam13683 273123006827 similar to Yersinia pestis YPO1874 conserved hypothetical protein (97.9% evalue=7.E-50);conserved hypothetical protein (likely pseudogene) 273123006828 similar to Yersinia pestis YPO1875 major tail sheath protein (partial) (95.6% evalue=2.E-18); Salmonella typhimurium STM2701 Fels-2 prophage: similar to tail sheath proteins in phage P2 (76.9% evalue=2.E-12); major tail sheath protein bacteriophage P2 (partial) 273123006829 2 probable transmembrane helices predicted by TMHMM2.0 273123006830 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 273123006831 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 273123006832 1 probable transmembrane helix predicted by TMHMM2.0 273123006833 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 273123006834 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 273123006835 Protein of unknown function (DUF497); Region: DUF497; pfam04365 273123006836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 273123006837 hypothetical protein 273123006838 similar to Yersinia pestis YPO1583 transposase for the IS285 insertion element (96.8% evalue=1.E-156); transposase (IS285) 273123006839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 273123006840 1 probable transmembrane helix predicted by TMHMM2.0 273123006841 similar to Vibrio cholerae VCA0508 transposase OrfAB, subunit B (69.9% evalue=6.E-44); Vibrio cholerae VC1478 transposase OrfAB, subunit B (69.9% evalue=6.E-44);transposase OrfAB, subunit B remnant 273123006842 hypothetical 273123006843 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 273123006844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123006845 DNA-binding site [nucleotide binding]; DNA binding site 273123006846 UTRA domain; Region: UTRA; pfam07702 273123006847 N-acetylmannosamine kinase; Provisional; Region: PRK05082 273123006848 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273123006849 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 273123006850 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 273123006851 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 273123006852 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 273123006853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123006854 dimer interface [polypeptide binding]; other site 273123006855 conserved gate region; other site 273123006856 putative PBP binding loops; other site 273123006857 ABC-ATPase subunit interface; other site 273123006858 6 probable transmembrane helices predicted by TMHMM2.0 273123006859 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273123006860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123006861 dimer interface [polypeptide binding]; other site 273123006862 conserved gate region; other site 273123006863 putative PBP binding loops; other site 273123006864 ABC-ATPase subunit interface; other site 273123006865 6 probable transmembrane helices predicted by TMHMM2.0 273123006866 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 273123006867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123006868 Walker A/P-loop; other site 273123006869 ATP binding site [chemical binding]; other site 273123006870 Q-loop/lid; other site 273123006871 ABC transporter signature motif; other site 273123006872 Walker B; other site 273123006873 D-loop; other site 273123006874 H-loop/switch region; other site 273123006875 TOBE domain; Region: TOBE_2; pfam08402 273123006876 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 273123006877 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 273123006878 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 273123006879 1 probable transmembrane helix predicted by TMHMM2.0 273123006880 Fimbrial protein; Region: Fimbrial; cl01416 273123006881 1 probable transmembrane helix predicted by TMHMM2.0 273123006882 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 273123006883 PapC N-terminal domain; Region: PapC_N; pfam13954 273123006884 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 273123006885 PapC C-terminal domain; Region: PapC_C; pfam13953 273123006886 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 273123006887 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 273123006888 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 273123006889 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 273123006890 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 273123006891 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123006892 substrate binding pocket [chemical binding]; other site 273123006893 membrane-bound complex binding site; other site 273123006894 hinge residues; other site 273123006895 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123006896 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 273123006897 substrate binding pocket [chemical binding]; other site 273123006898 membrane-bound complex binding site; other site 273123006899 hinge residues; other site 273123006900 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 273123006901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123006902 dimer interface [polypeptide binding]; other site 273123006903 phosphorylation site [posttranslational modification] 273123006904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123006905 ATP binding site [chemical binding]; other site 273123006906 Mg2+ binding site [ion binding]; other site 273123006907 G-X-G motif; other site 273123006908 Response regulator receiver domain; Region: Response_reg; pfam00072 273123006909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123006910 active site 273123006911 phosphorylation site [posttranslational modification] 273123006912 intermolecular recognition site; other site 273123006913 dimerization interface [polypeptide binding]; other site 273123006914 Hpt domain; Region: Hpt; pfam01627 273123006915 1 probable transmembrane helix predicted by TMHMM2.0 273123006916 transcriptional regulator FimZ; Provisional; Region: PRK09935 273123006917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123006918 active site 273123006919 phosphorylation site [posttranslational modification] 273123006920 intermolecular recognition site; other site 273123006921 dimerization interface [polypeptide binding]; other site 273123006922 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123006923 DNA binding residues [nucleotide binding] 273123006924 dimerization interface [polypeptide binding]; other site 273123006925 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 273123006926 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 273123006927 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 273123006928 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 273123006929 putative active site [active] 273123006930 putative catalytic site [active] 273123006931 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 273123006932 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 273123006933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123006934 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 273123006935 putative dimerization interface [polypeptide binding]; other site 273123006936 putative substrate binding pocket [chemical binding]; other site 273123006937 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 273123006938 1 probable transmembrane helix predicted by TMHMM2.0 273123006939 benzoate transport; Region: 2A0115; TIGR00895 273123006940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123006941 putative substrate translocation pore; other site 273123006942 12 probable transmembrane helices predicted by TMHMM2.0 273123006943 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 273123006944 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 273123006945 active site 273123006946 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123006947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123006948 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 273123006949 dimerization interface [polypeptide binding]; other site 273123006950 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK12456 273123006951 6 probable transmembrane helices predicted by TMHMM2.0 273123006952 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 273123006953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123006954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123006955 homodimer interface [polypeptide binding]; other site 273123006956 catalytic residue [active] 273123006957 L-asparagine permease; Provisional; Region: PRK15049 273123006958 12 probable transmembrane helices predicted by TMHMM2.0 273123006959 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 273123006960 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 273123006961 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 273123006962 glutaminase; Reviewed; Region: PRK12356 273123006963 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 273123006964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123006965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123006966 13 probable transmembrane helices predicted by TMHMM2.0 273123006967 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 273123006968 8 probable transmembrane helices predicted by TMHMM2.0 273123006969 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 273123006970 1 probable transmembrane helix predicted by TMHMM2.0 273123006971 Predicted membrane protein [Function unknown]; Region: COG4393 273123006972 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 273123006973 Uncharacterized conserved protein [Function unknown]; Region: COG3350 273123006974 8 probable transmembrane helices predicted by TMHMM2.0 273123006975 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 273123006976 FtsX-like permease family; Region: FtsX; pfam02687 273123006977 4 probable transmembrane helices predicted by TMHMM2.0 273123006978 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 273123006979 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 273123006980 FtsX-like permease family; Region: FtsX; pfam02687 273123006981 4 probable transmembrane helices predicted by TMHMM2.0 273123006982 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273123006983 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273123006984 Walker A/P-loop; other site 273123006985 ATP binding site [chemical binding]; other site 273123006986 Q-loop/lid; other site 273123006987 ABC transporter signature motif; other site 273123006988 Walker B; other site 273123006989 D-loop; other site 273123006990 H-loop/switch region; other site 273123006991 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 273123006992 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 273123006993 catalytic residues [active] 273123006994 Cytochrome c553 [Energy production and conversion]; Region: COG2863 273123006995 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 273123006996 tellurite resistance protein TehB; Provisional; Region: PRK12335 273123006997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123006998 S-adenosylmethionine binding site [chemical binding]; other site 273123006999 putative endopeptidase; Provisional; Region: PRK14576 273123007000 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 273123007001 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 273123007002 active site 273123007003 outer membrane protein; Provisional; Region: hmsH; PRK14574 273123007004 1 probable transmembrane helix predicted by TMHMM2.0 273123007005 outer membrane N-deacetylase; Provisional; Region: hmsF; PRK14581 273123007006 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 273123007007 putative active site [active] 273123007008 putative metal binding site [ion binding]; other site 273123007009 5 probable transmembrane helices predicted by TMHMM2.0 273123007010 N-glycosyltransferase; Provisional; Region: hmsR; PRK14583 273123007011 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 273123007012 DXD motif; other site 273123007013 hemin storage system protein; Provisional; Region: hmsS; PRK14584 273123007014 2 probable transmembrane helices predicted by TMHMM2.0 273123007015 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 273123007016 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 273123007017 1 probable transmembrane helix predicted by TMHMM2.0 273123007018 hypothetical protein; Provisional; Region: PRK10536 273123007019 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 273123007020 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 273123007021 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 273123007022 11 probable transmembrane helices predicted by TMHMM2.0 273123007023 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 273123007024 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 273123007025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123007026 dimerization interface [polypeptide binding]; other site 273123007027 Histidine kinase; Region: HisKA_3; pfam07730 273123007028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123007029 ATP binding site [chemical binding]; other site 273123007030 Mg2+ binding site [ion binding]; other site 273123007031 G-X-G motif; other site 273123007032 2 probable transmembrane helices predicted by TMHMM2.0 273123007033 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 273123007034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123007035 DNA-binding site [nucleotide binding]; DNA binding site 273123007036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123007037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123007038 homodimer interface [polypeptide binding]; other site 273123007039 catalytic residue [active] 273123007040 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 273123007041 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 273123007042 inhibitor-cofactor binding pocket; inhibition site 273123007043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123007044 catalytic residue [active] 273123007045 arginine succinyltransferase; Provisional; Region: PRK10456 273123007046 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 273123007047 succinylglutamic semialdehyde dehydrogenase; Region: arg_catab_astD; TIGR03240 273123007048 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 273123007049 NAD(P) binding site [chemical binding]; other site 273123007050 catalytic residues [active] 273123007051 succinylarginine dihydrolase; Provisional; Region: PRK13281 273123007052 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 273123007053 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 273123007054 putative active site [active] 273123007055 Zn binding site [ion binding]; other site 273123007056 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 273123007057 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 273123007058 trimer interface [polypeptide binding]; other site 273123007059 eyelet of channel; other site 273123007060 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 273123007061 imidazolonepropionase; Validated; Region: PRK09356 273123007062 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 273123007063 active site 273123007064 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 273123007065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123007066 DNA-binding site [nucleotide binding]; DNA binding site 273123007067 UTRA domain; Region: UTRA; pfam07702 273123007068 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 273123007069 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 273123007070 active site 273123007071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 273123007072 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 273123007073 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 273123007074 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 273123007075 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 273123007076 dimer interface [polypeptide binding]; other site 273123007077 active site 273123007078 CoA binding pocket [chemical binding]; other site 273123007079 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 273123007080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273123007081 NAD(P) binding site [chemical binding]; other site 273123007082 active site 273123007083 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 273123007084 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 273123007085 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 273123007086 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 273123007087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273123007088 NAD(P) binding site [chemical binding]; other site 273123007089 active site 273123007090 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 273123007091 active site 273123007092 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 273123007093 3 probable transmembrane helices predicted by TMHMM2.0 273123007094 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 273123007095 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 273123007096 active site 273123007097 TDP-binding site; other site 273123007098 acceptor substrate-binding pocket; other site 273123007099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 273123007100 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 273123007101 Sel1-like repeats; Region: SEL1; smart00671 273123007102 Sel1-like repeats; Region: SEL1; smart00671 273123007103 Sel1-like repeats; Region: SEL1; smart00671 273123007104 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 273123007105 2 probable transmembrane helices predicted by TMHMM2.0 273123007106 hypothetical protein; Provisional; Region: PRK09273 273123007107 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 273123007108 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 273123007109 Methyltransferase domain; Region: Methyltransf_12; pfam08242 273123007110 classical (c) SDRs; Region: SDR_c; cd05233 273123007111 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 273123007112 NAD(P) binding site [chemical binding]; other site 273123007113 active site 273123007114 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 273123007115 HEAT repeats; Region: HEAT_2; pfam13646 273123007116 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 273123007117 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 273123007118 catalytic site [active] 273123007119 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 273123007120 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 273123007121 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 273123007122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123007123 dimerization interface [polypeptide binding]; other site 273123007124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123007125 dimer interface [polypeptide binding]; other site 273123007126 phosphorylation site [posttranslational modification] 273123007127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123007128 ATP binding site [chemical binding]; other site 273123007129 Mg2+ binding site [ion binding]; other site 273123007130 G-X-G motif; other site 273123007131 2 probable transmembrane helices predicted by TMHMM2.0 273123007132 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 273123007133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123007134 active site 273123007135 phosphorylation site [posttranslational modification] 273123007136 intermolecular recognition site; other site 273123007137 dimerization interface [polypeptide binding]; other site 273123007138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123007139 DNA binding site [nucleotide binding] 273123007140 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 273123007141 flavodoxin; Provisional; Region: PRK06934 273123007142 1 probable transmembrane helix predicted by TMHMM2.0 273123007143 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 273123007144 6 probable transmembrane helices predicted by TMHMM2.0 273123007145 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 273123007146 GTP-binding protein YchF; Reviewed; Region: PRK09601 273123007147 YchF GTPase; Region: YchF; cd01900 273123007148 G1 box; other site 273123007149 GTP/Mg2+ binding site [chemical binding]; other site 273123007150 Switch I region; other site 273123007151 G2 box; other site 273123007152 Switch II region; other site 273123007153 G3 box; other site 273123007154 G4 box; other site 273123007155 G5 box; other site 273123007156 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 273123007157 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 273123007158 putative active site [active] 273123007159 catalytic residue [active] 273123007160 hypothetical protein; Provisional; Region: PRK10692 273123007161 2 probable transmembrane helices predicted by TMHMM2.0 273123007162 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 273123007163 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 273123007164 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273123007165 active site 273123007166 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 273123007167 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 273123007168 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 273123007169 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 273123007170 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 273123007171 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 273123007172 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 273123007173 tRNA; other site 273123007174 putative tRNA binding site [nucleotide binding]; other site 273123007175 putative NADP binding site [chemical binding]; other site 273123007176 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 273123007177 peptide chain release factor 1; Validated; Region: prfA; PRK00591 273123007178 This domain is found in peptide chain release factors; Region: PCRF; smart00937 273123007179 RF-1 domain; Region: RF-1; pfam00472 273123007180 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 273123007181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 273123007182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3094 273123007183 4 probable transmembrane helices predicted by TMHMM2.0 273123007184 hypothetical protein; Provisional; Region: PRK10941 273123007185 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 273123007186 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 273123007187 binding surface 273123007188 TPR motif; other site 273123007189 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 273123007190 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 273123007191 Transposase IS200 like; Region: Y1_Tnp; pfam01797 273123007192 putative transporter; Provisional; Region: PRK11660 273123007193 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 273123007194 Sulfate transporter family; Region: Sulfate_transp; pfam00916 273123007195 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 273123007196 8 probable transmembrane helices predicted by TMHMM2.0 273123007197 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 273123007198 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 273123007199 putative active site [active] 273123007200 catalytic site [active] 273123007201 putative metal binding site [ion binding]; other site 273123007202 1 probable transmembrane helix predicted by TMHMM2.0 273123007203 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 273123007204 hypothetical protein; Provisional; Region: PRK11622 273123007205 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 273123007206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123007207 dimer interface [polypeptide binding]; other site 273123007208 conserved gate region; other site 273123007209 putative PBP binding loops; other site 273123007210 ABC-ATPase subunit interface; other site 273123007211 6 probable transmembrane helices predicted by TMHMM2.0 273123007212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123007213 dimer interface [polypeptide binding]; other site 273123007214 conserved gate region; other site 273123007215 putative PBP binding loops; other site 273123007216 ABC-ATPase subunit interface; other site 273123007217 6 probable transmembrane helices predicted by TMHMM2.0 273123007218 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 273123007219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123007220 Walker A/P-loop; other site 273123007221 ATP binding site [chemical binding]; other site 273123007222 Q-loop/lid; other site 273123007223 ABC transporter signature motif; other site 273123007224 Walker B; other site 273123007225 D-loop; other site 273123007226 H-loop/switch region; other site 273123007227 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 273123007228 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 273123007229 active site 273123007230 catalytic site [active] 273123007231 Transcriptional regulators [Transcription]; Region: MarR; COG1846 273123007232 MarR family; Region: MarR_2; pfam12802 273123007233 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 273123007234 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 273123007235 putative hydrolase; Validated; Region: PRK09248 273123007236 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 273123007237 active site 273123007238 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 273123007239 lipoprotein; Provisional; Region: PRK10598 273123007240 multidrug resistance protein MdtH; Provisional; Region: PRK11646 273123007241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123007242 putative substrate translocation pore; other site 273123007243 10 probable transmembrane helices predicted by TMHMM2.0 273123007244 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 273123007245 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 273123007246 hypothetical protein; Provisional; Region: PRK11239 273123007247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 273123007248 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273123007249 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 273123007250 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 273123007251 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 273123007252 13 probable transmembrane helices predicted by TMHMM2.0 273123007253 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 273123007254 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 273123007255 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 273123007256 haemagglutination activity domain; Region: Haemagg_act; smart00912 273123007257 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 273123007258 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123007259 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123007260 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123007261 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 273123007262 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 273123007263 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 273123007264 active site 273123007265 HIGH motif; other site 273123007266 KMSK motif region; other site 273123007267 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 273123007268 tRNA binding surface [nucleotide binding]; other site 273123007269 anticodon binding site; other site 273123007270 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 273123007271 putative metal binding site [ion binding]; other site 273123007272 copper homeostasis protein CutC; Provisional; Region: PRK11572 273123007273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123007274 S-adenosylmethionine binding site [chemical binding]; other site 273123007275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123007276 S-adenosylmethionine binding site [chemical binding]; other site 273123007277 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 273123007278 4 probable transmembrane helices predicted by TMHMM2.0 273123007279 hypothetical protein; Provisional; Region: PRK10302 273123007280 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 273123007281 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 273123007282 dimer interface [polypeptide binding]; other site 273123007283 anticodon binding site; other site 273123007284 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 273123007285 homodimer interface [polypeptide binding]; other site 273123007286 motif 1; other site 273123007287 active site 273123007288 motif 2; other site 273123007289 GAD domain; Region: GAD; pfam02938 273123007290 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 273123007291 active site 273123007292 motif 3; other site 273123007293 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 273123007294 nudix motif; other site 273123007295 hypothetical protein; Validated; Region: PRK00110 273123007296 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 273123007297 active site 273123007298 putative DNA-binding cleft [nucleotide binding]; other site 273123007299 dimer interface [polypeptide binding]; other site 273123007300 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 273123007301 RuvA N terminal domain; Region: RuvA_N; pfam01330 273123007302 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 273123007303 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 273123007304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123007305 Walker A motif; other site 273123007306 ATP binding site [chemical binding]; other site 273123007307 Walker B motif; other site 273123007308 arginine finger; other site 273123007309 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 273123007310 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 273123007311 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123007312 ABC-ATPase subunit interface; other site 273123007313 dimer interface [polypeptide binding]; other site 273123007314 putative PBP binding regions; other site 273123007315 7 probable transmembrane helices predicted by TMHMM2.0 273123007316 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 273123007317 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 273123007318 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 273123007319 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 273123007320 metal binding site [ion binding]; metal-binding site 273123007321 1 probable transmembrane helix predicted by TMHMM2.0 273123007322 putative peptidase; Provisional; Region: PRK11649 273123007323 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 273123007324 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273123007325 Peptidase family M23; Region: Peptidase_M23; pfam01551 273123007326 1 probable transmembrane helix predicted by TMHMM2.0 273123007327 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 273123007328 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 273123007329 putative acyl-acceptor binding pocket; other site 273123007330 1 probable transmembrane helix predicted by TMHMM2.0 273123007331 pyruvate kinase; Provisional; Region: PRK05826 273123007332 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 273123007333 domain interfaces; other site 273123007334 active site 273123007335 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 273123007336 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273123007337 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273123007338 putative active site [active] 273123007339 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 273123007340 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 273123007341 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 273123007342 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 273123007343 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 273123007344 active site 273123007345 intersubunit interface [polypeptide binding]; other site 273123007346 catalytic residue [active] 273123007347 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 273123007348 4 probable transmembrane helices predicted by TMHMM2.0 273123007349 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 273123007350 4 probable transmembrane helices predicted by TMHMM2.0 273123007351 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 273123007352 homotrimer interaction site [polypeptide binding]; other site 273123007353 putative active site [active] 273123007354 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 273123007355 DEAD/DEAH box helicase; Region: DEAD; pfam00270 273123007356 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 273123007357 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 273123007358 Glycoprotease family; Region: Peptidase_M22; pfam00814 273123007359 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 273123007360 1 probable transmembrane helix predicted by TMHMM2.0 273123007361 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 273123007362 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 273123007363 acyl-activating enzyme (AAE) consensus motif; other site 273123007364 putative AMP binding site [chemical binding]; other site 273123007365 putative active site [active] 273123007366 putative CoA binding site [chemical binding]; other site 273123007367 ribonuclease D; Provisional; Region: PRK10829 273123007368 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 273123007369 catalytic site [active] 273123007370 putative active site [active] 273123007371 putative substrate binding site [chemical binding]; other site 273123007372 HRDC domain; Region: HRDC; pfam00570 273123007373 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 273123007374 cell division inhibitor MinD; Provisional; Region: PRK10818 273123007375 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 273123007376 Switch I; other site 273123007377 Switch II; other site 273123007378 septum formation inhibitor; Reviewed; Region: minC; PRK03511 273123007379 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 273123007380 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 273123007381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 273123007382 lytic murein transglycosylase; Region: MltB_2; TIGR02283 273123007383 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 273123007384 N-acetyl-D-glucosamine binding site [chemical binding]; other site 273123007385 catalytic residue [active] 273123007386 hypothetical protein; Provisional; Region: PRK10691 273123007387 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 273123007388 hypothetical protein; Provisional; Region: PRK05170 273123007389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123007390 putative substrate translocation pore; other site 273123007391 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273123007392 12 probable transmembrane helices predicted by TMHMM2.0 273123007393 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 273123007394 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 273123007395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123007396 catalytic residue [active] 273123007397 disulfide bond formation protein B; Provisional; Region: PRK01749 273123007398 4 probable transmembrane helices predicted by TMHMM2.0 273123007399 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 273123007400 9 probable transmembrane helices predicted by TMHMM2.0 273123007401 fatty acid metabolism regulator; Provisional; Region: PRK04984 273123007402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123007403 DNA-binding site [nucleotide binding]; DNA binding site 273123007404 FadR C-terminal domain; Region: FadR_C; pfam07840 273123007405 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 273123007406 SpoVR family protein; Provisional; Region: PRK11767 273123007407 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 273123007408 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 273123007409 hydroxyglutarate oxidase; Provisional; Region: PRK11728 273123007410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123007411 putative substrate translocation pore; other site 273123007412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273123007413 12 probable transmembrane helices predicted by TMHMM2.0 273123007414 Pirin-related protein [General function prediction only]; Region: COG1741 273123007415 Pirin; Region: Pirin; pfam02678 273123007416 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 273123007417 LysR family transcriptional regulator; Provisional; Region: PRK14997 273123007418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123007419 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 273123007420 putative effector binding pocket; other site 273123007421 putative dimerization interface [polypeptide binding]; other site 273123007422 EamA-like transporter family; Region: EamA; pfam00892 273123007423 10 probable transmembrane helices predicted by TMHMM2.0 273123007424 hypothetical protein; Provisional; Region: PRK05325 273123007425 PrkA family serine protein kinase; Provisional; Region: PRK15455 273123007426 AAA ATPase domain; Region: AAA_16; pfam13191 273123007427 Walker A motif; other site 273123007428 ATP binding site [chemical binding]; other site 273123007429 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 273123007430 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 273123007431 1 probable transmembrane helix predicted by TMHMM2.0 273123007432 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 273123007433 active site 273123007434 phosphate binding residues; other site 273123007435 catalytic residues [active] 273123007436 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 273123007437 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 273123007438 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 273123007439 methionine sulfoxide reductase B; Provisional; Region: PRK00222 273123007440 SelR domain; Region: SelR; pfam01641 273123007441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 273123007442 Isochorismatase family; Region: Isochorismatase; pfam00857 273123007443 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 273123007444 catalytic triad [active] 273123007445 metal binding site [ion binding]; metal-binding site 273123007446 conserved cis-peptide bond; other site 273123007447 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 273123007448 active site 273123007449 homodimer interface [polypeptide binding]; other site 273123007450 protease 4; Provisional; Region: PRK10949 273123007451 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 273123007452 tandem repeat interface [polypeptide binding]; other site 273123007453 oligomer interface [polypeptide binding]; other site 273123007454 active site residues [active] 273123007455 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 273123007456 tandem repeat interface [polypeptide binding]; other site 273123007457 oligomer interface [polypeptide binding]; other site 273123007458 active site residues [active] 273123007459 1 probable transmembrane helix predicted by TMHMM2.0 273123007460 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 273123007461 putative FMN binding site [chemical binding]; other site 273123007462 selenophosphate synthetase; Provisional; Region: PRK00943 273123007463 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 273123007464 dimerization interface [polypeptide binding]; other site 273123007465 putative ATP binding site [chemical binding]; other site 273123007466 DNA topoisomerase III; Provisional; Region: PRK07726 273123007467 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 273123007468 active site 273123007469 putative interdomain interaction site [polypeptide binding]; other site 273123007470 putative metal-binding site [ion binding]; other site 273123007471 putative nucleotide binding site [chemical binding]; other site 273123007472 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 273123007473 domain I; other site 273123007474 DNA binding groove [nucleotide binding] 273123007475 phosphate binding site [ion binding]; other site 273123007476 domain II; other site 273123007477 domain III; other site 273123007478 nucleotide binding site [chemical binding]; other site 273123007479 catalytic site [active] 273123007480 domain IV; other site 273123007481 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 273123007482 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 273123007483 active site 273123007484 8-oxo-dGMP binding site [chemical binding]; other site 273123007485 nudix motif; other site 273123007486 metal binding site [ion binding]; metal-binding site 273123007487 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 273123007488 putative catalytic site [active] 273123007489 putative phosphate binding site [ion binding]; other site 273123007490 active site 273123007491 metal binding site A [ion binding]; metal-binding site 273123007492 DNA binding site [nucleotide binding] 273123007493 putative AP binding site [nucleotide binding]; other site 273123007494 putative metal binding site B [ion binding]; other site 273123007495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123007496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123007497 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 273123007498 MULE transposase domain; Region: MULE; pfam10551 273123007499 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 273123007500 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 273123007501 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 273123007502 putative active site [active] 273123007503 putative substrate binding site [chemical binding]; other site 273123007504 putative cosubstrate binding site; other site 273123007505 catalytic site [active] 273123007506 SEC-C motif; Region: SEC-C; pfam02810 273123007507 hypothetical protein; Provisional; Region: PRK04233 273123007508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123007509 active site 273123007510 response regulator of RpoS; Provisional; Region: PRK10693 273123007511 phosphorylation site [posttranslational modification] 273123007512 intermolecular recognition site; other site 273123007513 dimerization interface [polypeptide binding]; other site 273123007514 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 273123007515 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 273123007516 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 273123007517 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 273123007518 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 273123007519 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 273123007520 thymidine kinase; Provisional; Region: PRK04296 273123007521 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 273123007522 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 273123007523 putative catalytic cysteine [active] 273123007524 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 273123007525 putative active site [active] 273123007526 metal binding site [ion binding]; metal-binding site 273123007527 hypothetical protein; Provisional; Region: PRK11111 273123007528 6 probable transmembrane helices predicted by TMHMM2.0 273123007529 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 273123007530 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 273123007531 peptide binding site [polypeptide binding]; other site 273123007532 1 probable transmembrane helix predicted by TMHMM2.0 273123007533 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 273123007534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123007535 dimer interface [polypeptide binding]; other site 273123007536 conserved gate region; other site 273123007537 putative PBP binding loops; other site 273123007538 ABC-ATPase subunit interface; other site 273123007539 6 probable transmembrane helices predicted by TMHMM2.0 273123007540 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 273123007541 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 273123007542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123007543 dimer interface [polypeptide binding]; other site 273123007544 conserved gate region; other site 273123007545 ABC-ATPase subunit interface; other site 273123007546 6 probable transmembrane helices predicted by TMHMM2.0 273123007547 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 273123007548 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123007549 Walker A/P-loop; other site 273123007550 ATP binding site [chemical binding]; other site 273123007551 Q-loop/lid; other site 273123007552 ABC transporter signature motif; other site 273123007553 Walker B; other site 273123007554 D-loop; other site 273123007555 H-loop/switch region; other site 273123007556 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 273123007557 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 273123007558 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123007559 Walker A/P-loop; other site 273123007560 ATP binding site [chemical binding]; other site 273123007561 Q-loop/lid; other site 273123007562 ABC transporter signature motif; other site 273123007563 Walker B; other site 273123007564 D-loop; other site 273123007565 H-loop/switch region; other site 273123007566 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 273123007567 dsDNA-mimic protein; Reviewed; Region: PRK05094 273123007568 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 273123007569 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 273123007570 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 273123007571 putative active site [active] 273123007572 catalytic site [active] 273123007573 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 273123007574 putative active site [active] 273123007575 catalytic site [active] 273123007576 2 probable transmembrane helices predicted by TMHMM2.0 273123007577 Yersinia protein of unknown function (DUF3831); Region: DUF3831; pfam12908 273123007578 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 273123007579 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 273123007580 YciI-like protein; Reviewed; Region: PRK11370 273123007581 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 273123007582 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 273123007583 1 probable transmembrane helix predicted by TMHMM2.0 273123007584 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 273123007585 intracellular septation protein A; Reviewed; Region: PRK00259 273123007586 5 probable transmembrane helices predicted by TMHMM2.0 273123007587 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 273123007588 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 273123007589 Sulfate transporter family; Region: Sulfate_transp; pfam00916 273123007590 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 273123007591 11 probable transmembrane helices predicted by TMHMM2.0 273123007592 hypothetical protein; Provisional; Region: PRK02868 273123007593 6 probable transmembrane helices predicted by TMHMM2.0 273123007594 outer membrane protein W; Provisional; Region: PRK10959 273123007595 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 273123007596 BON domain; Region: BON; pfam04972 273123007597 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 273123007598 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 273123007599 substrate binding site [chemical binding]; other site 273123007600 active site 273123007601 catalytic residues [active] 273123007602 heterodimer interface [polypeptide binding]; other site 273123007603 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 273123007604 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 273123007605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123007606 catalytic residue [active] 273123007607 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 273123007608 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 273123007609 active site 273123007610 ribulose/triose binding site [chemical binding]; other site 273123007611 phosphate binding site [ion binding]; other site 273123007612 substrate (anthranilate) binding pocket [chemical binding]; other site 273123007613 product (indole) binding pocket [chemical binding]; other site 273123007614 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 273123007615 active site 273123007616 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 273123007617 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 273123007618 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 273123007619 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 273123007620 Glutamine amidotransferase class-I; Region: GATase; pfam00117 273123007621 glutamine binding [chemical binding]; other site 273123007622 catalytic triad [active] 273123007623 anthranilate synthase component I; Provisional; Region: PRK13564 273123007624 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 273123007625 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 273123007626 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 273123007627 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 273123007628 active site 273123007629 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 273123007630 hypothetical protein; Provisional; Region: PRK11630 273123007631 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 273123007632 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273123007633 RNA binding surface [nucleotide binding]; other site 273123007634 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 273123007635 probable active site [active] 273123007636 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 273123007637 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 273123007638 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 273123007639 homodimer interface [polypeptide binding]; other site 273123007640 Walker A motif; other site 273123007641 ATP binding site [chemical binding]; other site 273123007642 hydroxycobalamin binding site [chemical binding]; other site 273123007643 Walker B motif; other site 273123007644 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 273123007645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273123007646 NAD(P) binding site [chemical binding]; other site 273123007647 active site 273123007648 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 273123007649 putative inner membrane peptidase; Provisional; Region: PRK11778 273123007650 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 273123007651 tandem repeat interface [polypeptide binding]; other site 273123007652 oligomer interface [polypeptide binding]; other site 273123007653 active site residues [active] 273123007654 1 probable transmembrane helix predicted by TMHMM2.0 273123007655 hypothetical protein; Provisional; Region: PRK11037 273123007656 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 273123007657 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 273123007658 active site 273123007659 interdomain interaction site; other site 273123007660 putative metal-binding site [ion binding]; other site 273123007661 nucleotide binding site [chemical binding]; other site 273123007662 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 273123007663 domain I; other site 273123007664 DNA binding groove [nucleotide binding] 273123007665 phosphate binding site [ion binding]; other site 273123007666 domain II; other site 273123007667 domain III; other site 273123007668 nucleotide binding site [chemical binding]; other site 273123007669 catalytic site [active] 273123007670 domain IV; other site 273123007671 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 273123007672 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 273123007673 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 273123007674 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 273123007675 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 273123007676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123007677 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 273123007678 substrate binding site [chemical binding]; other site 273123007679 putative dimerization interface [polypeptide binding]; other site 273123007680 aconitate hydratase; Validated; Region: PRK09277 273123007681 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 273123007682 substrate binding site [chemical binding]; other site 273123007683 ligand binding site [chemical binding]; other site 273123007684 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 273123007685 substrate binding site [chemical binding]; other site 273123007686 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 273123007687 dimerization interface [polypeptide binding]; other site 273123007688 active site 273123007689 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 273123007690 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 273123007691 active site 273123007692 6 probable transmembrane helices predicted by TMHMM2.0 273123007693 Predicted membrane protein [Function unknown]; Region: COG3771 273123007694 2 probable transmembrane helices predicted by TMHMM2.0 273123007695 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 273123007696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273123007697 TPR motif; other site 273123007698 binding surface 273123007699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 273123007700 binding surface 273123007701 TPR motif; other site 273123007702 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 273123007703 active site 273123007704 dimer interface [polypeptide binding]; other site 273123007705 translation initiation factor Sui1; Validated; Region: PRK06824 273123007706 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 273123007707 putative rRNA binding site [nucleotide binding]; other site 273123007708 lipoprotein; Provisional; Region: PRK10540 273123007709 1 probable transmembrane helix predicted by TMHMM2.0 273123007710 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 273123007711 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 273123007712 intersubunit interface [polypeptide binding]; other site 273123007713 active site 273123007714 Zn2+ binding site [ion binding]; other site 273123007715 Uncharacterized conserved protein [Function unknown]; Region: COG5460 273123007716 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 273123007717 active site 273123007718 intersubunit interactions; other site 273123007719 catalytic residue [active] 273123007720 Uncharacterized small protein [Function unknown]; Region: COG2879 273123007721 carbon starvation protein A; Provisional; Region: PRK15015 273123007722 Carbon starvation protein CstA; Region: CstA; pfam02554 273123007723 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 273123007724 16 probable transmembrane helices predicted by TMHMM2.0 273123007725 exoribonuclease II; Provisional; Region: PRK05054 273123007726 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 273123007727 RNB domain; Region: RNB; pfam00773 273123007728 S1 RNA binding domain; Region: S1; pfam00575 273123007729 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 273123007730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123007731 putative substrate translocation pore; other site 273123007732 12 probable transmembrane helices predicted by TMHMM2.0 273123007733 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 273123007734 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 273123007735 putative NAD(P) binding site [chemical binding]; other site 273123007736 active site 273123007737 putative substrate binding site [chemical binding]; other site 273123007738 endonuclease III; Provisional; Region: PRK10702 273123007739 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 273123007740 minor groove reading motif; other site 273123007741 helix-hairpin-helix signature motif; other site 273123007742 substrate binding pocket [chemical binding]; other site 273123007743 active site 273123007744 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 273123007745 electron transport complex RsxE subunit; Provisional; Region: PRK12405 273123007746 5 probable transmembrane helices predicted by TMHMM2.0 273123007747 electron transport complex protein RnfG; Validated; Region: PRK01908 273123007748 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 273123007749 7 probable transmembrane helices predicted by TMHMM2.0 273123007750 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 273123007751 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123007752 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 273123007753 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 273123007754 SLBB domain; Region: SLBB; pfam10531 273123007755 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273123007756 electron transport complex protein RnfB; Provisional; Region: PRK05113 273123007757 Putative Fe-S cluster; Region: FeS; pfam04060 273123007758 4Fe-4S binding domain; Region: Fer4; pfam00037 273123007759 1 probable transmembrane helix predicted by TMHMM2.0 273123007760 electron transport complex protein RsxA; Provisional; Region: PRK05151 273123007761 6 probable transmembrane helices predicted by TMHMM2.0 273123007762 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 273123007763 4 probable transmembrane helices predicted by TMHMM2.0 273123007764 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 273123007765 putative active site [active] 273123007766 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 273123007767 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273123007768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123007769 Walker A/P-loop; other site 273123007770 ATP binding site [chemical binding]; other site 273123007771 Q-loop/lid; other site 273123007772 ABC transporter signature motif; other site 273123007773 Walker B; other site 273123007774 D-loop; other site 273123007775 H-loop/switch region; other site 273123007776 5 probable transmembrane helices predicted by TMHMM2.0 273123007777 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 273123007778 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123007779 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123007780 1 probable transmembrane helix predicted by TMHMM2.0 273123007781 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 273123007782 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 273123007783 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273123007784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123007785 Walker A/P-loop; other site 273123007786 ATP binding site [chemical binding]; other site 273123007787 Q-loop/lid; other site 273123007788 ABC transporter signature motif; other site 273123007789 Walker B; other site 273123007790 D-loop; other site 273123007791 H-loop/switch region; other site 273123007792 5 probable transmembrane helices predicted by TMHMM2.0 273123007793 L-arabinose isomerase; Provisional; Region: PRK02929 273123007794 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 273123007795 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 273123007796 trimer interface [polypeptide binding]; other site 273123007797 putative substrate binding site [chemical binding]; other site 273123007798 putative metal binding site [ion binding]; other site 273123007799 ribulokinase; Provisional; Region: PRK04123 273123007800 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 273123007801 N- and C-terminal domain interface [polypeptide binding]; other site 273123007802 active site 273123007803 MgATP binding site [chemical binding]; other site 273123007804 catalytic site [active] 273123007805 metal binding site [ion binding]; metal-binding site 273123007806 carbohydrate binding site [chemical binding]; other site 273123007807 homodimer interface [polypeptide binding]; other site 273123007808 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 273123007809 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 273123007810 ligand binding site [chemical binding]; other site 273123007811 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 273123007812 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123007813 Walker A/P-loop; other site 273123007814 ATP binding site [chemical binding]; other site 273123007815 Q-loop/lid; other site 273123007816 ABC transporter signature motif; other site 273123007817 Walker B; other site 273123007818 D-loop; other site 273123007819 H-loop/switch region; other site 273123007820 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123007821 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123007822 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123007823 TM-ABC transporter signature motif; other site 273123007824 9 probable transmembrane helices predicted by TMHMM2.0 273123007825 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 273123007826 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 273123007827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123007828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123007829 putative oxidoreductase; Provisional; Region: PRK11579 273123007830 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 273123007831 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 273123007832 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 273123007833 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 273123007834 9 probable transmembrane helices predicted by TMHMM2.0 273123007835 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 273123007836 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 273123007837 active site 273123007838 purine riboside binding site [chemical binding]; other site 273123007839 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 273123007840 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123007841 DNA-binding site [nucleotide binding]; DNA binding site 273123007842 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 273123007843 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 273123007844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 273123007845 1 probable transmembrane helix predicted by TMHMM2.0 273123007846 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 273123007847 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 273123007848 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 273123007849 fumarate hydratase; Reviewed; Region: fumC; PRK00485 273123007850 Class II fumarases; Region: Fumarase_classII; cd01362 273123007851 active site 273123007852 tetramer interface [polypeptide binding]; other site 273123007853 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 273123007854 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 273123007855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123007856 putative substrate translocation pore; other site 273123007857 12 probable transmembrane helices predicted by TMHMM2.0 273123007858 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 273123007859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123007860 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 273123007861 dimerization interface [polypeptide binding]; other site 273123007862 substrate binding pocket [chemical binding]; other site 273123007863 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 273123007864 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 273123007865 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 273123007866 nucleotide binding site [chemical binding]; other site 273123007867 putative dithiobiotin synthetase; Provisional; Region: PRK12374 273123007868 AAA domain; Region: AAA_26; pfam13500 273123007869 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 273123007870 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 273123007871 Cl- selectivity filter; other site 273123007872 Cl- binding residues [ion binding]; other site 273123007873 pore gating glutamate residue; other site 273123007874 dimer interface [polypeptide binding]; other site 273123007875 11 probable transmembrane helices predicted by TMHMM2.0 273123007876 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 273123007877 hypothetical protein; Provisional; Region: PRK13659 273123007878 malonic semialdehyde reductase; Provisional; Region: PRK10538 273123007879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273123007880 NAD(P) binding site [chemical binding]; other site 273123007881 active site 273123007882 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 273123007883 GAF domain; Region: GAF; pfam01590 273123007884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123007885 Walker A motif; other site 273123007886 ATP binding site [chemical binding]; other site 273123007887 Walker B motif; other site 273123007888 arginine finger; other site 273123007889 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 273123007890 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 273123007891 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 273123007892 NAD(P) binding site [chemical binding]; other site 273123007893 catalytic residues [active] 273123007894 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 273123007895 EamA-like transporter family; Region: EamA; pfam00892 273123007896 EamA-like transporter family; Region: EamA; pfam00892 273123007897 10 probable transmembrane helices predicted by TMHMM2.0 273123007898 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 273123007899 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123007900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123007901 homodimer interface [polypeptide binding]; other site 273123007902 catalytic residue [active] 273123007903 similar to Salmonella typhimurium STM1556 Na+/H+ antiporter (79.6% evalue=1.E-78); H. influenzae HI1107 hypothetical na+/H+ antiporter HI1107 (55.7% evalue=4.E-49); Citation: Carnoy et al. (2002) J. Bacteriol. 184:4489-4499;pseudogene (C-terminal 1/3 of AAK28540.1 from Y. pseudotuberculosis AH strain) 273123007904 3 probable transmembrane helices predicted by TMHMM2.0 273123007905 similar to Yersinia pestis YPO2283 LacI-family transcriptional regulatory protein (99.6% evalue=1.E-167); Salmonella typhimurium STM1555 transcriptional regulator (69.6% evalue=1.E-119); Citation: Carnoy et al. (2002) J. Bacteriol. 184:4489-4499; pseudogene of a LacI-family transcriptional regulatory protein 273123007906 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 273123007907 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 273123007908 ligand binding site [chemical binding]; other site 273123007909 dimerization interface [polypeptide binding]; other site 273123007910 1 probable transmembrane helix predicted by TMHMM2.0 273123007911 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123007912 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123007913 TM-ABC transporter signature motif; other site 273123007914 10 probable transmembrane helices predicted by TMHMM2.0 273123007915 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123007916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123007917 Walker A/P-loop; other site 273123007918 ATP binding site [chemical binding]; other site 273123007919 Q-loop/lid; other site 273123007920 ABC transporter signature motif; other site 273123007921 Walker B; other site 273123007922 D-loop; other site 273123007923 H-loop/switch region; other site 273123007924 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123007925 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 273123007926 1 probable transmembrane helix predicted by TMHMM2.0 273123007927 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 273123007928 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 273123007929 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 273123007930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123007931 dimer interface [polypeptide binding]; other site 273123007932 conserved gate region; other site 273123007933 putative PBP binding loops; other site 273123007934 ABC-ATPase subunit interface; other site 273123007935 6 probable transmembrane helices predicted by TMHMM2.0 273123007936 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 273123007937 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 273123007938 Walker A/P-loop; other site 273123007939 ATP binding site [chemical binding]; other site 273123007940 Q-loop/lid; other site 273123007941 ABC transporter signature motif; other site 273123007942 Walker B; other site 273123007943 D-loop; other site 273123007944 H-loop/switch region; other site 273123007945 AMP nucleosidase; Provisional; Region: PRK08292 273123007946 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 273123007947 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 273123007948 ribonuclease E; Reviewed; Region: rne; PRK10811 273123007949 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 273123007950 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 273123007951 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 273123007952 G1 box; other site 273123007953 GTP/Mg2+ binding site [chemical binding]; other site 273123007954 G2 box; other site 273123007955 Switch I region; other site 273123007956 G3 box; other site 273123007957 Switch II region; other site 273123007958 G4 box; other site 273123007959 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 273123007960 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 273123007961 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 273123007962 PYR/PP interface [polypeptide binding]; other site 273123007963 dimer interface [polypeptide binding]; other site 273123007964 TPP binding site [chemical binding]; other site 273123007965 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 273123007966 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 273123007967 TPP-binding site [chemical binding]; other site 273123007968 dimer interface [polypeptide binding]; other site 273123007969 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 273123007970 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 273123007971 putative valine binding site [chemical binding]; other site 273123007972 dimer interface [polypeptide binding]; other site 273123007973 dUMP phosphatase; Provisional; Region: PRK09449 273123007974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123007975 motif II; other site 273123007976 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 273123007977 tellurite resistance protein terB; Region: terB; cd07176 273123007978 putative metal binding site [ion binding]; other site 273123007979 1 probable transmembrane helix predicted by TMHMM2.0 273123007980 alkaline phosphatase; Provisional; Region: PRK10518 273123007981 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 273123007982 dimer interface [polypeptide binding]; other site 273123007983 active site 273123007984 1 probable transmembrane helix predicted by TMHMM2.0 273123007985 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 273123007986 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 273123007987 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 273123007988 DNA binding site [nucleotide binding] 273123007989 active site 273123007990 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 273123007991 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 273123007992 ligand binding site [chemical binding]; other site 273123007993 flexible hinge region; other site 273123007994 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 273123007995 putative switch regulator; other site 273123007996 non-specific DNA interactions [nucleotide binding]; other site 273123007997 DNA binding site [nucleotide binding] 273123007998 sequence specific DNA binding site [nucleotide binding]; other site 273123007999 putative cAMP binding site [chemical binding]; other site 273123008000 universal stress protein UspE; Provisional; Region: PRK11175 273123008001 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 273123008002 Ligand Binding Site [chemical binding]; other site 273123008003 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 273123008004 Ligand Binding Site [chemical binding]; other site 273123008005 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 273123008006 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 273123008007 9 probable transmembrane helices predicted by TMHMM2.0 273123008008 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 273123008009 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 273123008010 ligand binding site [chemical binding]; other site 273123008011 homodimer interface [polypeptide binding]; other site 273123008012 NAD(P) binding site [chemical binding]; other site 273123008013 trimer interface B [polypeptide binding]; other site 273123008014 trimer interface A [polypeptide binding]; other site 273123008015 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 273123008016 5 probable transmembrane helices predicted by TMHMM2.0 273123008017 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 273123008018 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 273123008019 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 273123008020 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 273123008021 13 probable transmembrane helices predicted by TMHMM2.0 273123008022 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 273123008023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123008024 active site 273123008025 phosphorylation site [posttranslational modification] 273123008026 intermolecular recognition site; other site 273123008027 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123008028 DNA binding site [nucleotide binding] 273123008029 sensor protein RstB; Provisional; Region: PRK10604 273123008030 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123008031 dimerization interface [polypeptide binding]; other site 273123008032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123008033 dimer interface [polypeptide binding]; other site 273123008034 phosphorylation site [posttranslational modification] 273123008035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123008036 ATP binding site [chemical binding]; other site 273123008037 Mg2+ binding site [ion binding]; other site 273123008038 G-X-G motif; other site 273123008039 2 probable transmembrane helices predicted by TMHMM2.0 273123008040 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 273123008041 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 273123008042 active site 273123008043 Zn binding site [ion binding]; other site 273123008044 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 273123008045 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 273123008046 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 273123008047 hypothetical protein; Provisional; Region: PRK03757 273123008048 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 273123008049 4 probable transmembrane helices predicted by TMHMM2.0 273123008050 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 273123008051 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 273123008052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273123008053 non-specific DNA binding site [nucleotide binding]; other site 273123008054 salt bridge; other site 273123008055 sequence-specific DNA binding site [nucleotide binding]; other site 273123008056 Phage-related protein [Function unknown]; Region: COG4679 273123008057 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 273123008058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273123008059 ATP binding site [chemical binding]; other site 273123008060 putative Mg++ binding site [ion binding]; other site 273123008061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123008062 nucleotide binding region [chemical binding]; other site 273123008063 ATP-binding site [chemical binding]; other site 273123008064 Helicase associated domain (HA2); Region: HA2; pfam04408 273123008065 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 273123008066 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 273123008067 azoreductase; Reviewed; Region: PRK00170 273123008068 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 273123008069 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 273123008070 MarR family; Region: MarR_2; pfam12802 273123008071 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 273123008072 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 273123008073 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 273123008074 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 273123008075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 273123008076 1 probable transmembrane helix predicted by TMHMM2.0 273123008077 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 273123008078 hypothetical protein; Provisional; Region: PRK10695 273123008079 1 probable transmembrane helix predicted by TMHMM2.0 273123008080 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 273123008081 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 273123008082 putative ligand binding site [chemical binding]; other site 273123008083 putative NAD binding site [chemical binding]; other site 273123008084 catalytic site [active] 273123008085 heat-inducible protein; Provisional; Region: PRK10449 273123008086 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 273123008087 Domain of unknown function (DUF333); Region: DUF333; pfam03891 273123008088 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 273123008089 MgtC family; Region: MgtC; pfam02308 273123008090 5 probable transmembrane helices predicted by TMHMM2.0 273123008091 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 273123008092 4 probable transmembrane helices predicted by TMHMM2.0 273123008093 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 273123008094 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 273123008095 dimer interface [polypeptide binding]; other site 273123008096 PYR/PP interface [polypeptide binding]; other site 273123008097 TPP binding site [chemical binding]; other site 273123008098 substrate binding site [chemical binding]; other site 273123008099 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 273123008100 Domain of unknown function; Region: EKR; pfam10371 273123008101 4Fe-4S binding domain; Region: Fer4_6; pfam12837 273123008102 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273123008103 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 273123008104 TPP-binding site [chemical binding]; other site 273123008105 dimer interface [polypeptide binding]; other site 273123008106 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 273123008107 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 273123008108 Ligand Binding Site [chemical binding]; other site 273123008109 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 273123008110 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 273123008111 substrate binding pocket [chemical binding]; other site 273123008112 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 273123008113 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 273123008114 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 273123008115 DNA binding residues [nucleotide binding] 273123008116 dimer interface [polypeptide binding]; other site 273123008117 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 273123008118 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 273123008119 Cl binding site [ion binding]; other site 273123008120 oligomer interface [polypeptide binding]; other site 273123008121 2 probable transmembrane helices predicted by TMHMM2.0 273123008122 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 273123008123 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 273123008124 peptide binding site [polypeptide binding]; other site 273123008125 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 273123008126 murein peptide amidase A; Provisional; Region: PRK10602 273123008127 active site 273123008128 Zn binding site [ion binding]; other site 273123008129 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 273123008130 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 273123008131 active site 273123008132 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 273123008133 dimer interface [polypeptide binding]; other site 273123008134 catalytic triad [active] 273123008135 peroxidatic and resolving cysteines [active] 273123008136 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 273123008137 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 273123008138 PAS domain; Region: PAS; smart00091 273123008139 putative active site [active] 273123008140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123008141 Walker A motif; other site 273123008142 ATP binding site [chemical binding]; other site 273123008143 Walker B motif; other site 273123008144 arginine finger; other site 273123008145 Uncharacterized conserved protein [Function unknown]; Region: COG5642 273123008146 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 273123008147 Uncharacterized conserved protein [Function unknown]; Region: COG5654 273123008148 hypothetical protein; Provisional; Region: PRK05415 273123008149 Domain of unknown function (DUF697); Region: DUF697; cl12064 273123008150 3 probable transmembrane helices predicted by TMHMM2.0 273123008151 Predicted ATPase [General function prediction only]; Region: COG3106 273123008152 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; pfam09584 273123008153 1 probable transmembrane helix predicted by TMHMM2.0 273123008154 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 273123008155 phage shock protein C; Region: phageshock_pspC; TIGR02978 273123008156 1 probable transmembrane helix predicted by TMHMM2.0 273123008157 phage shock protein B; Provisional; Region: pspB; PRK09458 273123008158 1 probable transmembrane helix predicted by TMHMM2.0 273123008159 phage shock protein PspA; Provisional; Region: PRK10698 273123008160 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 273123008161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123008162 Walker A motif; other site 273123008163 ATP binding site [chemical binding]; other site 273123008164 Walker B motif; other site 273123008165 arginine finger; other site 273123008166 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 273123008167 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 273123008168 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 273123008169 peptide binding site [polypeptide binding]; other site 273123008170 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 273123008171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123008172 dimer interface [polypeptide binding]; other site 273123008173 conserved gate region; other site 273123008174 putative PBP binding loops; other site 273123008175 ABC-ATPase subunit interface; other site 273123008176 5 probable transmembrane helices predicted by TMHMM2.0 273123008177 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 273123008178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123008179 putative PBP binding loops; other site 273123008180 dimer interface [polypeptide binding]; other site 273123008181 ABC-ATPase subunit interface; other site 273123008182 4 probable transmembrane helices predicted by TMHMM2.0 273123008183 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 273123008184 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123008185 Walker A/P-loop; other site 273123008186 ATP binding site [chemical binding]; other site 273123008187 Q-loop/lid; other site 273123008188 ABC transporter signature motif; other site 273123008189 Walker B; other site 273123008190 D-loop; other site 273123008191 H-loop/switch region; other site 273123008192 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273123008193 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 273123008194 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123008195 Walker A/P-loop; other site 273123008196 ATP binding site [chemical binding]; other site 273123008197 Q-loop/lid; other site 273123008198 ABC transporter signature motif; other site 273123008199 Walker B; other site 273123008200 D-loop; other site 273123008201 H-loop/switch region; other site 273123008202 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273123008203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 273123008204 Uncharacterized conserved protein [Function unknown]; Region: COG2128 273123008205 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 273123008206 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 273123008207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123008208 putative substrate translocation pore; other site 273123008209 POT family; Region: PTR2; pfam00854 273123008210 14 probable transmembrane helices predicted by TMHMM2.0 273123008211 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 273123008212 5 probable transmembrane helices predicted by TMHMM2.0 273123008213 hypothetical protein; Provisional; Region: PRK10515 273123008214 glutathionine S-transferase; Provisional; Region: PRK10542 273123008215 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 273123008216 C-terminal domain interface [polypeptide binding]; other site 273123008217 GSH binding site (G-site) [chemical binding]; other site 273123008218 dimer interface [polypeptide binding]; other site 273123008219 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 273123008220 dimer interface [polypeptide binding]; other site 273123008221 N-terminal domain interface [polypeptide binding]; other site 273123008222 substrate binding pocket (H-site) [chemical binding]; other site 273123008223 pyridoxamine kinase; Validated; Region: PRK05756 273123008224 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 273123008225 dimer interface [polypeptide binding]; other site 273123008226 pyridoxal binding site [chemical binding]; other site 273123008227 ATP binding site [chemical binding]; other site 273123008228 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 273123008229 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 273123008230 active site 273123008231 HIGH motif; other site 273123008232 dimer interface [polypeptide binding]; other site 273123008233 KMSKS motif; other site 273123008234 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273123008235 RNA binding surface [nucleotide binding]; other site 273123008236 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 273123008237 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 273123008238 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 273123008239 Predicted periplasmic protein [General function prediction only]; Region: COG3895 273123008240 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 273123008241 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 273123008242 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 273123008243 transcriptional regulator SlyA; Provisional; Region: PRK03573 273123008244 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 273123008245 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273123008246 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273123008247 active site 273123008248 catalytic tetrad [active] 273123008249 Predicted Fe-S protein [General function prediction only]; Region: COG3313 273123008250 putative metal dependent hydrolase; Provisional; Region: PRK11598 273123008251 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 273123008252 Sulfatase; Region: Sulfatase; pfam00884 273123008253 5 probable transmembrane helices predicted by TMHMM2.0 273123008254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 273123008255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 273123008256 1 probable transmembrane helix predicted by TMHMM2.0 273123008257 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 273123008258 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 273123008259 FMN binding site [chemical binding]; other site 273123008260 active site 273123008261 substrate binding site [chemical binding]; other site 273123008262 catalytic residue [active] 273123008263 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 273123008264 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 273123008265 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 273123008266 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 273123008267 dimer interface [polypeptide binding]; other site 273123008268 active site 273123008269 metal binding site [ion binding]; metal-binding site 273123008270 glutathione binding site [chemical binding]; other site 273123008271 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 273123008272 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 273123008273 dimer interface [polypeptide binding]; other site 273123008274 catalytic site [active] 273123008275 putative active site [active] 273123008276 putative substrate binding site [chemical binding]; other site 273123008277 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 273123008278 putative GSH binding site [chemical binding]; other site 273123008279 catalytic residues [active] 273123008280 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 273123008281 NlpC/P60 family; Region: NLPC_P60; pfam00877 273123008282 superoxide dismutase; Provisional; Region: PRK10543 273123008283 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 273123008284 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 273123008285 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 273123008286 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123008287 DNA binding site [nucleotide binding] 273123008288 domain linker motif; other site 273123008289 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 273123008290 dimerization interface [polypeptide binding]; other site 273123008291 ligand binding site [chemical binding]; other site 273123008292 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 273123008293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123008294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273123008295 dimerization interface [polypeptide binding]; other site 273123008296 putative transporter; Provisional; Region: PRK11043 273123008297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123008298 putative substrate translocation pore; other site 273123008299 12 probable transmembrane helices predicted by TMHMM2.0 273123008300 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 273123008301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123008302 S-adenosylmethionine binding site [chemical binding]; other site 273123008303 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 273123008304 Lumazine binding domain; Region: Lum_binding; pfam00677 273123008305 Lumazine binding domain; Region: Lum_binding; pfam00677 273123008306 multidrug efflux protein; Reviewed; Region: PRK01766 273123008307 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 273123008308 cation binding site [ion binding]; other site 273123008309 12 probable transmembrane helices predicted by TMHMM2.0 273123008310 pyruvate kinase; Provisional; Region: PRK09206 273123008311 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 273123008312 domain interfaces; other site 273123008313 active site 273123008314 murein lipoprotein; Provisional; Region: PRK15396 273123008315 L,D-transpeptidase; Provisional; Region: PRK10190 273123008316 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 273123008317 cysteine desufuration protein SufE; Provisional; Region: PRK09296 273123008318 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 273123008319 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 273123008320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123008321 catalytic residue [active] 273123008322 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 273123008323 FeS assembly protein SufD; Region: sufD; TIGR01981 273123008324 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 273123008325 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 273123008326 Walker A/P-loop; other site 273123008327 ATP binding site [chemical binding]; other site 273123008328 Q-loop/lid; other site 273123008329 ABC transporter signature motif; other site 273123008330 Walker B; other site 273123008331 D-loop; other site 273123008332 H-loop/switch region; other site 273123008333 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 273123008334 putative ABC transporter; Region: ycf24; CHL00085 273123008335 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 273123008336 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 273123008337 CoenzymeA binding site [chemical binding]; other site 273123008338 subunit interaction site [polypeptide binding]; other site 273123008339 PHB binding site; other site 273123008340 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 273123008341 FAD binding domain; Region: FAD_binding_4; pfam01565 273123008342 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 273123008343 putative inner membrane protein; Provisional; Region: PRK10983 273123008344 Domain of unknown function DUF20; Region: UPF0118; pfam01594 273123008345 8 probable transmembrane helices predicted by TMHMM2.0 273123008346 phosphoenolpyruvate synthase; Validated; Region: PRK06464 273123008347 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 273123008348 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 273123008349 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 273123008350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 273123008351 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 273123008352 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 273123008353 hypothetical protein; Validated; Region: PRK00029 273123008354 Uncharacterized conserved protein [Function unknown]; Region: COG0397 273123008355 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 273123008356 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 273123008357 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 273123008358 NlpC/P60 family; Region: NLPC_P60; pfam00877 273123008359 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 273123008360 4 probable transmembrane helices predicted by TMHMM2.0 273123008361 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 273123008362 3 probable transmembrane helices predicted by TMHMM2.0 273123008363 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 273123008364 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 273123008365 11 probable transmembrane helices predicted by TMHMM2.0 273123008366 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 273123008367 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 273123008368 putative active site [active] 273123008369 putative catalytic site [active] 273123008370 putative Zn binding site [ion binding]; other site 273123008371 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 273123008372 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 273123008373 active site 273123008374 substrate binding site [chemical binding]; other site 273123008375 cosubstrate binding site; other site 273123008376 catalytic site [active] 273123008377 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 273123008378 active site 273123008379 hexamer interface [polypeptide binding]; other site 273123008380 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 273123008381 NAD binding site [chemical binding]; other site 273123008382 substrate binding site [chemical binding]; other site 273123008383 active site 273123008384 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 273123008385 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 273123008386 Ligand binding site; other site 273123008387 Putative Catalytic site; other site 273123008388 DXD motif; other site 273123008389 2 probable transmembrane helices predicted by TMHMM2.0 273123008390 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 273123008391 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 273123008392 inhibitor-cofactor binding pocket; inhibition site 273123008393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123008394 catalytic residue [active] 273123008395 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 273123008396 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 273123008397 Walker A/P-loop; other site 273123008398 ATP binding site [chemical binding]; other site 273123008399 Q-loop/lid; other site 273123008400 ABC transporter signature motif; other site 273123008401 Walker B; other site 273123008402 D-loop; other site 273123008403 H-loop/switch region; other site 273123008404 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 273123008405 catalytic residues [active] 273123008406 dimer interface [polypeptide binding]; other site 273123008407 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 273123008408 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123008409 ABC-ATPase subunit interface; other site 273123008410 dimer interface [polypeptide binding]; other site 273123008411 putative PBP binding regions; other site 273123008412 8 probable transmembrane helices predicted by TMHMM2.0 273123008413 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 273123008414 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 273123008415 IHF dimer interface [polypeptide binding]; other site 273123008416 IHF - DNA interface [nucleotide binding]; other site 273123008417 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 273123008418 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 273123008419 putative tRNA-binding site [nucleotide binding]; other site 273123008420 B3/4 domain; Region: B3_4; pfam03483 273123008421 tRNA synthetase B5 domain; Region: B5; smart00874 273123008422 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 273123008423 dimer interface [polypeptide binding]; other site 273123008424 motif 1; other site 273123008425 motif 3; other site 273123008426 motif 2; other site 273123008427 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 273123008428 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 273123008429 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 273123008430 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 273123008431 dimer interface [polypeptide binding]; other site 273123008432 motif 1; other site 273123008433 active site 273123008434 motif 2; other site 273123008435 motif 3; other site 273123008436 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 273123008437 23S rRNA binding site [nucleotide binding]; other site 273123008438 L21 binding site [polypeptide binding]; other site 273123008439 L13 binding site [polypeptide binding]; other site 273123008440 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 273123008441 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 273123008442 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 273123008443 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 273123008444 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 273123008445 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 273123008446 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 273123008447 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 273123008448 active site 273123008449 dimer interface [polypeptide binding]; other site 273123008450 motif 1; other site 273123008451 motif 2; other site 273123008452 motif 3; other site 273123008453 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 273123008454 anticodon binding site; other site 273123008455 KTSC domain; Region: KTSC; pfam13619 273123008456 2 probable transmembrane helices predicted by TMHMM2.0 273123008457 inner membrane protein; Provisional; Region: PRK10995 273123008458 6 probable transmembrane helices predicted by TMHMM2.0 273123008459 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 273123008460 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 273123008461 N-acetyl-D-glucosamine binding site [chemical binding]; other site 273123008462 catalytic residue [active] 273123008463 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 273123008464 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 273123008465 metal binding site [ion binding]; metal-binding site 273123008466 1 probable transmembrane helix predicted by TMHMM2.0 273123008467 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 273123008468 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 273123008469 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 273123008470 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123008471 ABC-ATPase subunit interface; other site 273123008472 dimer interface [polypeptide binding]; other site 273123008473 putative PBP binding regions; other site 273123008474 7 probable transmembrane helices predicted by TMHMM2.0 273123008475 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 273123008476 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123008477 ABC-ATPase subunit interface; other site 273123008478 dimer interface [polypeptide binding]; other site 273123008479 putative PBP binding regions; other site 273123008480 8 probable transmembrane helices predicted by TMHMM2.0 273123008481 1 probable transmembrane helix predicted by TMHMM2.0 273123008482 Phosphotransferase enzyme family; Region: APH; pfam01636 273123008483 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 273123008484 active site 273123008485 ATP binding site [chemical binding]; other site 273123008486 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 273123008487 YniB-like protein; Region: YniB; pfam14002 273123008488 3 probable transmembrane helices predicted by TMHMM2.0 273123008489 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 273123008490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123008491 motif II; other site 273123008492 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 273123008493 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 273123008494 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 273123008495 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 273123008496 NADP binding site [chemical binding]; other site 273123008497 homodimer interface [polypeptide binding]; other site 273123008498 active site 273123008499 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 273123008500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123008501 dimer interface [polypeptide binding]; other site 273123008502 conserved gate region; other site 273123008503 putative PBP binding loops; other site 273123008504 ABC-ATPase subunit interface; other site 273123008505 8 probable transmembrane helices predicted by TMHMM2.0 273123008506 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273123008507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123008508 dimer interface [polypeptide binding]; other site 273123008509 conserved gate region; other site 273123008510 putative PBP binding loops; other site 273123008511 ABC-ATPase subunit interface; other site 273123008512 6 probable transmembrane helices predicted by TMHMM2.0 273123008513 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 273123008514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123008515 Walker A/P-loop; other site 273123008516 ATP binding site [chemical binding]; other site 273123008517 Q-loop/lid; other site 273123008518 ABC transporter signature motif; other site 273123008519 Walker B; other site 273123008520 D-loop; other site 273123008521 H-loop/switch region; other site 273123008522 TOBE domain; Region: TOBE_2; pfam08402 273123008523 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 273123008524 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 273123008525 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 273123008526 1 probable transmembrane helix predicted by TMHMM2.0 273123008527 inner membrane protein; Provisional; Region: PRK11648 273123008528 3 probable transmembrane helices predicted by TMHMM2.0 273123008529 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 273123008530 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 273123008531 9 probable transmembrane helices predicted by TMHMM2.0 273123008532 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 273123008533 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 273123008534 amidase catalytic site [active] 273123008535 Zn binding residues [ion binding]; other site 273123008536 substrate binding site [chemical binding]; other site 273123008537 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 273123008538 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 273123008539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273123008540 dimerization interface [polypeptide binding]; other site 273123008541 putative Zn2+ binding site [ion binding]; other site 273123008542 putative DNA binding site [nucleotide binding]; other site 273123008543 Bacterial transcriptional regulator; Region: IclR; pfam01614 273123008544 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 273123008545 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 273123008546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123008547 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273123008548 putative substrate translocation pore; other site 273123008549 12 probable transmembrane helices predicted by TMHMM2.0 273123008550 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 273123008551 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 273123008552 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 273123008553 1 probable transmembrane helix predicted by TMHMM2.0 273123008554 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 273123008555 1 probable transmembrane helix predicted by TMHMM2.0 273123008556 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 273123008557 PapC N-terminal domain; Region: PapC_N; pfam13954 273123008558 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 273123008559 PapC C-terminal domain; Region: PapC_C; pfam13953 273123008560 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 273123008561 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 273123008562 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 273123008563 1 probable transmembrane helix predicted by TMHMM2.0 273123008564 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 273123008565 1 probable transmembrane helix predicted by TMHMM2.0 273123008566 heat shock protein HtpX; Provisional; Region: PRK05457 273123008567 4 probable transmembrane helices predicted by TMHMM2.0 273123008568 carboxy-terminal protease; Provisional; Region: PRK11186 273123008569 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 273123008570 protein binding site [polypeptide binding]; other site 273123008571 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 273123008572 Catalytic dyad [active] 273123008573 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 273123008574 ProP expression regulator; Provisional; Region: PRK04950 273123008575 ProQ/FINO family; Region: ProQ; pfam04352 273123008576 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 273123008577 GAF domain; Region: GAF_2; pfam13185 273123008578 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 273123008579 Paraquat-inducible protein A; Region: PqiA; pfam04403 273123008580 Paraquat-inducible protein A; Region: PqiA; pfam04403 273123008581 8 probable transmembrane helices predicted by TMHMM2.0 273123008582 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 273123008583 mce related protein; Region: MCE; pfam02470 273123008584 mce related protein; Region: MCE; pfam02470 273123008585 mce related protein; Region: MCE; pfam02470 273123008586 mce related protein; Region: MCE; pfam02470 273123008587 mce related protein; Region: MCE; pfam02470 273123008588 mce related protein; Region: MCE; pfam02470 273123008589 1 probable transmembrane helix predicted by TMHMM2.0 273123008590 Uncharacterized secreted protein [Function unknown]; Region: COG5430 273123008591 2 probable transmembrane helices predicted by TMHMM2.0 273123008592 Uncharacterized secreted protein [Function unknown]; Region: COG5430 273123008593 1 probable transmembrane helix predicted by TMHMM2.0 273123008594 Uncharacterized secreted protein [Function unknown]; Region: COG5430 273123008595 similar to Yersinia pestis YPO1697 chaperone protein (97.6% evalue=2.E-91); Pseudomonas aeruginosa PA4651 probable pili assembly chaperone (38.5% evalue=2.E-27); chaperone protein 273123008596 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 273123008597 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 273123008598 PapC C-terminal domain; Region: PapC_C; pfam13953 273123008599 1 probable transmembrane helix predicted by TMHMM2.0 273123008600 Spore Coat Protein U domain; Region: SCPU; pfam05229 273123008601 Uncharacterized secreted protein [Function unknown]; Region: COG5430 273123008602 3 probable transmembrane helices predicted by TMHMM2.0 273123008603 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 273123008604 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 273123008605 Patatin-like phospholipase; Region: Patatin; pfam01734 273123008606 nucleophile elbow; other site 273123008607 1 probable transmembrane helix predicted by TMHMM2.0 273123008608 Lipase; Region: Lipase; pfam00151 273123008609 alanine racemase; Reviewed; Region: PRK13340 273123008610 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826 273123008611 active site 273123008612 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273123008613 dimer interface [polypeptide binding]; other site 273123008614 substrate binding site [chemical binding]; other site 273123008615 catalytic residues [active] 273123008616 1 probable transmembrane helix predicted by TMHMM2.0 273123008617 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 273123008618 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 273123008619 trimer interface [polypeptide binding]; other site 273123008620 YadA-like C-terminal region; Region: YadA; pfam03895 273123008621 1 probable transmembrane helix predicted by TMHMM2.0 273123008622 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 273123008623 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 273123008624 amidase catalytic site [active] 273123008625 Zn binding residues [ion binding]; other site 273123008626 substrate binding site [chemical binding]; other site 273123008627 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 273123008628 chemotaxis regulator CheZ; Provisional; Region: PRK11166 273123008629 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 273123008630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123008631 active site 273123008632 phosphorylation site [posttranslational modification] 273123008633 intermolecular recognition site; other site 273123008634 dimerization interface [polypeptide binding]; other site 273123008635 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 273123008636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123008637 active site 273123008638 phosphorylation site [posttranslational modification] 273123008639 intermolecular recognition site; other site 273123008640 dimerization interface [polypeptide binding]; other site 273123008641 CheB methylesterase; Region: CheB_methylest; pfam01339 273123008642 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 273123008643 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 273123008644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123008645 methyl-accepting protein IV; Provisional; Region: PRK09793 273123008646 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 273123008647 dimer interface [polypeptide binding]; other site 273123008648 ligand binding site [chemical binding]; other site 273123008649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123008650 dimerization interface [polypeptide binding]; other site 273123008651 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 273123008652 dimer interface [polypeptide binding]; other site 273123008653 putative CheW interface [polypeptide binding]; other site 273123008654 2 probable transmembrane helices predicted by TMHMM2.0 273123008655 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 273123008656 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 273123008657 dimer interface [polypeptide binding]; other site 273123008658 ligand binding site [chemical binding]; other site 273123008659 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123008660 dimerization interface [polypeptide binding]; other site 273123008661 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 273123008662 dimer interface [polypeptide binding]; other site 273123008663 putative CheW interface [polypeptide binding]; other site 273123008664 2 probable transmembrane helices predicted by TMHMM2.0 273123008665 hypothetical protein; Provisional; Region: PRK10215 273123008666 1 probable transmembrane helix predicted by TMHMM2.0 273123008667 Predicted membrane protein [Function unknown]; Region: COG5373 273123008668 25 probable transmembrane helices predicted by TMHMM2.0 273123008669 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 273123008670 putative CheA interaction surface; other site 273123008671 chemotaxis protein CheA; Provisional; Region: PRK10547 273123008672 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 273123008673 putative binding surface; other site 273123008674 active site 273123008675 CheY binding; Region: CheY-binding; pfam09078 273123008676 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 273123008677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123008678 ATP binding site [chemical binding]; other site 273123008679 Mg2+ binding site [ion binding]; other site 273123008680 G-X-G motif; other site 273123008681 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 273123008682 flagellar motor protein MotB; Validated; Region: motB; PRK09041 273123008683 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 273123008684 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 273123008685 ligand binding site [chemical binding]; other site 273123008686 1 probable transmembrane helix predicted by TMHMM2.0 273123008687 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 273123008688 flagellar motor protein MotA; Validated; Region: PRK09110 273123008689 4 probable transmembrane helices predicted by TMHMM2.0 273123008690 similar to Yersinia pestis YPO1663 flhC; flagellum biosynthesis transcription activator (100% evalue=1.E-87); Escherichia coli JW1880 flhC; Flagellar transcriptional activator FlhC (83.4% evalue=2.E-72);flagellum biosynthesis transcription activator 273123008691 transcriptional activator FlhD; Provisional; Region: PRK02909 273123008692 magnesium-transporting ATPase; Provisional; Region: PRK15122 273123008693 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 273123008694 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273123008695 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 273123008696 Soluble P-type ATPase [General function prediction only]; Region: COG4087 273123008697 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 273123008698 8 probable transmembrane helices predicted by TMHMM2.0 273123008699 magnesium transport protein MgtC; Provisional; Region: PRK15385 273123008700 MgtC family; Region: MgtC; pfam02308 273123008701 4 probable transmembrane helices predicted by TMHMM2.0 273123008702 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 273123008703 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 273123008704 dimer interface [polypeptide binding]; other site 273123008705 ligand binding site [chemical binding]; other site 273123008706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123008707 dimerization interface [polypeptide binding]; other site 273123008708 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 273123008709 dimer interface [polypeptide binding]; other site 273123008710 putative CheW interface [polypeptide binding]; other site 273123008711 2 probable transmembrane helices predicted by TMHMM2.0 273123008712 hypothetical protein; Provisional; Region: PRK10708 273123008713 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273123008714 DNA-binding site [nucleotide binding]; DNA binding site 273123008715 RNA-binding motif; other site 273123008716 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 273123008717 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 273123008718 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 273123008719 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 273123008720 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 273123008721 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 273123008722 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 273123008723 NAD(P) binding site [chemical binding]; other site 273123008724 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 273123008725 2 probable transmembrane helices predicted by TMHMM2.0 273123008726 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 273123008727 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 273123008728 putative DNA binding site [nucleotide binding]; other site 273123008729 putative Zn2+ binding site [ion binding]; other site 273123008730 AsnC family; Region: AsnC_trans_reg; pfam01037 273123008731 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 273123008732 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 273123008733 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 273123008734 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 273123008735 catalytic core [active] 273123008736 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 273123008737 Predicted transcriptional regulators [Transcription]; Region: COG1733 273123008738 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 273123008739 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 273123008740 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 273123008741 NADP binding site [chemical binding]; other site 273123008742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273123008743 PAS domain; Region: PAS_9; pfam13426 273123008744 putative active site [active] 273123008745 heme pocket [chemical binding]; other site 273123008746 HAMP domain; Region: HAMP; pfam00672 273123008747 dimerization interface [polypeptide binding]; other site 273123008748 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 273123008749 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 273123008750 dimer interface [polypeptide binding]; other site 273123008751 putative CheW interface [polypeptide binding]; other site 273123008752 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273123008753 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123008754 DNA binding site [nucleotide binding] 273123008755 domain linker motif; other site 273123008756 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 273123008757 putative dimerization interface [polypeptide binding]; other site 273123008758 putative ligand binding site [chemical binding]; other site 273123008759 isocitrate dehydrogenase; Validated; Region: PRK07362 273123008760 isocitrate dehydrogenase; Reviewed; Region: PRK07006 273123008761 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 273123008762 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 273123008763 probable active site [active] 273123008764 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 273123008765 nudix motif; other site 273123008766 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 273123008767 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 273123008768 putative lysogenization regulator; Reviewed; Region: PRK00218 273123008769 adenylosuccinate lyase; Provisional; Region: PRK09285 273123008770 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 273123008771 tetramer interface [polypeptide binding]; other site 273123008772 active site 273123008773 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 273123008774 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 273123008775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123008776 active site 273123008777 phosphorylation site [posttranslational modification] 273123008778 intermolecular recognition site; other site 273123008779 dimerization interface [polypeptide binding]; other site 273123008780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123008781 DNA binding site [nucleotide binding] 273123008782 sensor protein PhoQ; Provisional; Region: PRK10815 273123008783 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 273123008784 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 273123008785 dimer interface [polypeptide binding]; other site 273123008786 phosphorylation site [posttranslational modification] 273123008787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123008788 ATP binding site [chemical binding]; other site 273123008789 Mg2+ binding site [ion binding]; other site 273123008790 G-X-G motif; other site 273123008791 2 probable transmembrane helices predicted by TMHMM2.0 273123008792 Uncharacterized conserved protein [Function unknown]; Region: COG2850 273123008793 Cupin-like domain; Region: Cupin_8; pfam13621 273123008794 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 273123008795 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 273123008796 metal binding site [ion binding]; metal-binding site 273123008797 dimer interface [polypeptide binding]; other site 273123008798 NAD-dependent deacetylase; Provisional; Region: PRK00481 273123008799 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 273123008800 NAD+ binding site [chemical binding]; other site 273123008801 substrate binding site [chemical binding]; other site 273123008802 Zn binding site [ion binding]; other site 273123008803 fructokinase; Reviewed; Region: PRK09557 273123008804 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 273123008805 nucleotide binding site [chemical binding]; other site 273123008806 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 273123008807 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 273123008808 FtsX-like permease family; Region: FtsX; pfam02687 273123008809 4 probable transmembrane helices predicted by TMHMM2.0 273123008810 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 273123008811 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273123008812 Walker A/P-loop; other site 273123008813 ATP binding site [chemical binding]; other site 273123008814 Q-loop/lid; other site 273123008815 ABC transporter signature motif; other site 273123008816 Walker B; other site 273123008817 D-loop; other site 273123008818 H-loop/switch region; other site 273123008819 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 273123008820 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 273123008821 FtsX-like permease family; Region: FtsX; pfam02687 273123008822 4 probable transmembrane helices predicted by TMHMM2.0 273123008823 transcription-repair coupling factor; Provisional; Region: PRK10689 273123008824 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 273123008825 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273123008826 ATP binding site [chemical binding]; other site 273123008827 putative Mg++ binding site [ion binding]; other site 273123008828 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123008829 nucleotide binding region [chemical binding]; other site 273123008830 ATP-binding site [chemical binding]; other site 273123008831 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 273123008832 hypothetical protein; Provisional; Region: PRK11280 273123008833 1 probable transmembrane helix predicted by TMHMM2.0 273123008834 1 probable transmembrane helix predicted by TMHMM2.0 273123008835 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 273123008836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273123008837 hypothetical protein; Provisional; Region: PRK04940 273123008838 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 273123008839 beta-hexosaminidase; Provisional; Region: PRK05337 273123008840 thiamine kinase; Region: ycfN_thiK; TIGR02721 273123008841 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 273123008842 active site 273123008843 substrate binding site [chemical binding]; other site 273123008844 ATP binding site [chemical binding]; other site 273123008845 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 273123008846 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 273123008847 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 273123008848 putative dimer interface [polypeptide binding]; other site 273123008849 1 probable transmembrane helix predicted by TMHMM2.0 273123008850 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 273123008851 nucleotide binding site/active site [active] 273123008852 HIT family signature motif; other site 273123008853 catalytic residue [active] 273123008854 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 273123008855 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 273123008856 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 273123008857 shikimate binding site; other site 273123008858 NAD(P) binding site [chemical binding]; other site 273123008859 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276 273123008860 AAA domain; Region: AAA_23; pfam13476 273123008861 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 273123008862 Phage-related protein [Function unknown]; Region: COG4695; cl01923 273123008863 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 273123008864 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 273123008865 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 273123008866 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 273123008867 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 273123008868 active site turn [active] 273123008869 phosphorylation site [posttranslational modification] 273123008870 9 probable transmembrane helices predicted by TMHMM2.0 273123008871 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 273123008872 active site 273123008873 DNA polymerase III subunit delta'; Validated; Region: PRK07993 273123008874 DNA polymerase III subunit delta'; Validated; Region: PRK08485 273123008875 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 273123008876 thymidylate kinase; Validated; Region: tmk; PRK00698 273123008877 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 273123008878 TMP-binding site; other site 273123008879 ATP-binding site [chemical binding]; other site 273123008880 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 273123008881 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 273123008882 dimerization interface [polypeptide binding]; other site 273123008883 1 probable transmembrane helix predicted by TMHMM2.0 273123008884 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 273123008885 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 273123008886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123008887 catalytic residue [active] 273123008888 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 273123008889 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 273123008890 dimer interface [polypeptide binding]; other site 273123008891 active site 273123008892 acyl carrier protein; Provisional; Region: acpP; PRK00982 273123008893 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 273123008894 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 273123008895 NAD(P) binding site [chemical binding]; other site 273123008896 homotetramer interface [polypeptide binding]; other site 273123008897 homodimer interface [polypeptide binding]; other site 273123008898 active site 273123008899 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 273123008900 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 273123008901 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 273123008902 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 273123008903 dimer interface [polypeptide binding]; other site 273123008904 active site 273123008905 CoA binding pocket [chemical binding]; other site 273123008906 Fatty acid/phospholipid biosynthesis enzyme [Lipid metabolism]; Region: PlsX; COG0416 273123008907 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 273123008908 hypothetical protein; Provisional; Region: PRK11193 273123008909 Maf-like protein; Region: Maf; pfam02545 273123008910 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 273123008911 active site 273123008912 dimer interface [polypeptide binding]; other site 273123008913 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 273123008914 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273123008915 RNA binding surface [nucleotide binding]; other site 273123008916 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 273123008917 active site 273123008918 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 273123008919 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 273123008920 homodimer interface [polypeptide binding]; other site 273123008921 oligonucleotide binding site [chemical binding]; other site 273123008922 Integrase core domain; Region: rve_3; cl15866 273123008923 Uncharacterized conserved protein [Function unknown]; Region: COG1359 273123008924 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 273123008925 active site 273123008926 substrate binding pocket [chemical binding]; other site 273123008927 dimer interface [polypeptide binding]; other site 273123008928 DNA damage-inducible protein I; Provisional; Region: PRK10597 273123008929 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 273123008930 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 273123008931 hydroxyglutarate oxidase; Provisional; Region: PRK11728 273123008932 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 273123008933 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123008934 DNA binding residues [nucleotide binding] 273123008935 dimerization interface [polypeptide binding]; other site 273123008936 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 273123008937 Domain of unknown function DUF20; Region: UPF0118; pfam01594 273123008938 7 probable transmembrane helices predicted by TMHMM2.0 273123008939 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 273123008940 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 273123008941 active site residue [active] 273123008942 2 probable transmembrane helices predicted by TMHMM2.0 273123008943 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 273123008944 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 273123008945 putative acyl-acceptor binding pocket; other site 273123008946 1 probable transmembrane helix predicted by TMHMM2.0 273123008947 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 273123008948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123008949 putative substrate translocation pore; other site 273123008950 POT family; Region: PTR2; cl17359 273123008951 14 probable transmembrane helices predicted by TMHMM2.0 273123008952 lipoprotein; Provisional; Region: PRK10175 273123008953 1 probable transmembrane helix predicted by TMHMM2.0 273123008954 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 273123008955 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 273123008956 Ligand binding site; other site 273123008957 DXD motif; other site 273123008958 6 probable transmembrane helices predicted by TMHMM2.0 273123008959 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 273123008960 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 273123008961 similar to Escherichia coli ECs1425 glucans biosynthesis protein (55% evalue=1.E-13);glucans biosynthesis protein (partial) 273123008962 8 probable transmembrane helices predicted by TMHMM2.0 273123008963 potassium/proton antiporter; Reviewed; Region: PRK05326 273123008964 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 273123008965 TrkA-C domain; Region: TrkA_C; pfam02080 273123008966 Transporter associated domain; Region: CorC_HlyC; smart01091 273123008967 13 probable transmembrane helices predicted by TMHMM2.0 273123008968 EamA-like transporter family; Region: EamA; pfam00892 273123008969 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 273123008970 EamA-like transporter family; Region: EamA; pfam00892 273123008971 10 probable transmembrane helices predicted by TMHMM2.0 273123008972 Autoinducer synthetase; Region: Autoind_synth; pfam00765 273123008973 Autoinducer binding domain; Region: Autoind_bind; pfam03472 273123008974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123008975 DNA binding residues [nucleotide binding] 273123008976 dimerization interface [polypeptide binding]; other site 273123008977 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 273123008978 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123008979 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273123008980 dimerization interface [polypeptide binding]; other site 273123008981 benzoate transport; Region: 2A0115; TIGR00895 273123008982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123008983 putative substrate translocation pore; other site 273123008984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123008985 12 probable transmembrane helices predicted by TMHMM2.0 273123008986 Formaldehyde-activating enzyme nesessary for methanogenesis [Energy production and conversion]; Region: COG1795 273123008987 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273123008988 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273123008989 active site 273123008990 catalytic tetrad [active] 273123008991 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09674 273123008992 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 273123008993 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09676 273123008994 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 273123008995 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 273123008996 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 273123008997 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 273123008998 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 273123008999 Mechanosensitive ion channel; Region: MS_channel; pfam00924 273123009000 5 probable transmembrane helices predicted by TMHMM2.0 273123009001 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 273123009002 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 273123009003 active site 273123009004 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273123009005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009006 dimer interface [polypeptide binding]; other site 273123009007 conserved gate region; other site 273123009008 putative PBP binding loops; other site 273123009009 ABC-ATPase subunit interface; other site 273123009010 6 probable transmembrane helices predicted by TMHMM2.0 273123009011 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 273123009012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009013 dimer interface [polypeptide binding]; other site 273123009014 putative PBP binding loops; other site 273123009015 ABC-ATPase subunit interface; other site 273123009016 7 probable transmembrane helices predicted by TMHMM2.0 273123009017 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 273123009018 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 273123009019 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273123009020 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123009021 DNA binding site [nucleotide binding] 273123009022 domain linker motif; other site 273123009023 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 273123009024 putative dimerization interface [polypeptide binding]; other site 273123009025 putative ligand binding site [chemical binding]; other site 273123009026 phosphomannomutase CpsG; Provisional; Region: PRK15414 273123009027 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 273123009028 active site 273123009029 substrate binding site [chemical binding]; other site 273123009030 metal binding site [ion binding]; metal-binding site 273123009031 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 273123009032 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 273123009033 Walker A/P-loop; other site 273123009034 ATP binding site [chemical binding]; other site 273123009035 Q-loop/lid; other site 273123009036 ABC transporter signature motif; other site 273123009037 Walker B; other site 273123009038 D-loop; other site 273123009039 H-loop/switch region; other site 273123009040 TOBE domain; Region: TOBE_2; pfam08402 273123009041 similar to Yersinia pestis YPO2482 hypothetical protein (75% evalue=4.E-25);pseudogene 5' end of gene deleted 273123009042 similar to Yersinia pestis YPO2490 hemolysin (99.1% evalue=1.E-127);pseudogene-remnant of hemolysin 273123009043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4304 273123009044 haemagglutination activity domain; Region: Haemagg_act; pfam05860 273123009045 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 273123009046 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123009047 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123009048 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 273123009049 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 273123009050 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 273123009051 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 273123009052 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 273123009053 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 273123009054 FMN-binding pocket [chemical binding]; other site 273123009055 flavin binding motif; other site 273123009056 phosphate binding motif [ion binding]; other site 273123009057 beta-alpha-beta structure motif; other site 273123009058 NAD binding pocket [chemical binding]; other site 273123009059 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 273123009060 catalytic loop [active] 273123009061 iron binding site [ion binding]; other site 273123009062 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 273123009063 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 273123009064 [2Fe-2S] cluster binding site [ion binding]; other site 273123009065 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 273123009066 putative alpha subunit interface [polypeptide binding]; other site 273123009067 putative active site [active] 273123009068 putative substrate binding site [chemical binding]; other site 273123009069 Fe binding site [ion binding]; other site 273123009070 putative transporter; Provisional; Region: PRK09950 273123009071 12 probable transmembrane helices predicted by TMHMM2.0 273123009072 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 273123009073 tartrate dehydrogenase; Region: TTC; TIGR02089 273123009074 transcriptional activator TtdR; Provisional; Region: PRK09801 273123009075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123009076 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 273123009077 putative effector binding pocket; other site 273123009078 putative dimerization interface [polypeptide binding]; other site 273123009079 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273123009080 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123009081 DNA binding site [nucleotide binding] 273123009082 domain linker motif; other site 273123009083 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 273123009084 dimerization interface [polypeptide binding]; other site 273123009085 ligand binding site [chemical binding]; other site 273123009086 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123009087 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123009088 TM-ABC transporter signature motif; other site 273123009089 7 probable transmembrane helices predicted by TMHMM2.0 273123009090 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123009091 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123009092 Walker A/P-loop; other site 273123009093 ATP binding site [chemical binding]; other site 273123009094 Q-loop/lid; other site 273123009095 ABC transporter signature motif; other site 273123009096 Walker B; other site 273123009097 D-loop; other site 273123009098 H-loop/switch region; other site 273123009099 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123009100 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 273123009101 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 273123009102 putative ligand binding site [chemical binding]; other site 273123009103 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 273123009104 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 273123009105 putative NAD(P) binding site [chemical binding]; other site 273123009106 catalytic Zn binding site [ion binding]; other site 273123009107 structural Zn binding site [ion binding]; other site 273123009108 1 probable transmembrane helix predicted by TMHMM2.0 273123009109 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: COG3965 273123009110 6 probable transmembrane helices predicted by TMHMM2.0 273123009111 outer membrane protein X; Provisional; Region: ompX; PRK09408 273123009112 1 probable transmembrane helix predicted by TMHMM2.0 273123009113 threonine and homoserine efflux system; Provisional; Region: PRK10532 273123009114 10 probable transmembrane helices predicted by TMHMM2.0 273123009115 putative acetyltransferase YhhY; Provisional; Region: PRK10140 273123009116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273123009117 Coenzyme A binding pocket [chemical binding]; other site 273123009118 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 273123009119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123009120 S-adenosylmethionine binding site [chemical binding]; other site 273123009121 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 273123009122 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 273123009123 dimerization interface [polypeptide binding]; other site 273123009124 DPS ferroxidase diiron center [ion binding]; other site 273123009125 ion pore; other site 273123009126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273123009127 TPR motif; other site 273123009128 binding surface 273123009129 Uncharacterized conserved protein [Function unknown]; Region: COG1434 273123009130 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 273123009131 putative active site [active] 273123009132 1 probable transmembrane helix predicted by TMHMM2.0 273123009133 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 273123009134 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123009135 substrate binding pocket [chemical binding]; other site 273123009136 membrane-bound complex binding site; other site 273123009137 hinge residues; other site 273123009138 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 273123009139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009140 dimer interface [polypeptide binding]; other site 273123009141 conserved gate region; other site 273123009142 putative PBP binding loops; other site 273123009143 ABC-ATPase subunit interface; other site 273123009144 4 probable transmembrane helices predicted by TMHMM2.0 273123009145 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 273123009146 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 273123009147 Walker A/P-loop; other site 273123009148 ATP binding site [chemical binding]; other site 273123009149 Q-loop/lid; other site 273123009150 ABC transporter signature motif; other site 273123009151 Walker B; other site 273123009152 D-loop; other site 273123009153 H-loop/switch region; other site 273123009154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273123009155 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 273123009156 putative active site [active] 273123009157 heme pocket [chemical binding]; other site 273123009158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273123009159 putative active site [active] 273123009160 heme pocket [chemical binding]; other site 273123009161 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 273123009162 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 273123009163 dimer interface [polypeptide binding]; other site 273123009164 putative CheW interface [polypeptide binding]; other site 273123009165 1 probable transmembrane helix predicted by TMHMM2.0 273123009166 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 273123009167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123009168 S-adenosylmethionine binding site [chemical binding]; other site 273123009169 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 273123009170 1 probable transmembrane helix predicted by TMHMM2.0 273123009171 glycosyl transferase family protein; Provisional; Region: PRK08136 273123009172 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 273123009173 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 273123009174 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 273123009175 acyl-activating enzyme (AAE) consensus motif; other site 273123009176 putative AMP binding site [chemical binding]; other site 273123009177 putative active site [active] 273123009178 putative CoA binding site [chemical binding]; other site 273123009179 O-succinylbenzoate synthase; Provisional; Region: PRK05105 273123009180 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 273123009181 active site 273123009182 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 273123009183 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 273123009184 substrate binding site [chemical binding]; other site 273123009185 oxyanion hole (OAH) forming residues; other site 273123009186 trimer interface [polypeptide binding]; other site 273123009187 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 273123009188 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 273123009189 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 273123009190 dimer interface [polypeptide binding]; other site 273123009191 tetramer interface [polypeptide binding]; other site 273123009192 PYR/PP interface [polypeptide binding]; other site 273123009193 TPP binding site [chemical binding]; other site 273123009194 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 273123009195 TPP-binding site; other site 273123009196 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 273123009197 chorismate binding enzyme; Region: Chorismate_bind; cl10555 273123009198 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 273123009199 1 probable transmembrane helix predicted by TMHMM2.0 273123009200 phosphogluconate dehydratase; Validated; Region: PRK09054 273123009201 6-phosphogluconate dehydratase; Region: edd; TIGR01196 273123009202 Domain of unknown function (DUF336); Region: DUF336; cl01249 273123009203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123009204 D-galactonate transporter; Region: 2A0114; TIGR00893 273123009205 putative substrate translocation pore; other site 273123009206 11 probable transmembrane helices predicted by TMHMM2.0 273123009207 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 273123009208 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 273123009209 putative ligand binding site [chemical binding]; other site 273123009210 NAD binding site [chemical binding]; other site 273123009211 catalytic site [active] 273123009212 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 273123009213 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123009214 DNA binding site [nucleotide binding] 273123009215 domain linker motif; other site 273123009216 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 273123009217 putative ligand binding site [chemical binding]; other site 273123009218 putative dimerization interface [polypeptide binding]; other site 273123009219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 273123009220 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 273123009221 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 273123009222 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 273123009223 NADP binding site [chemical binding]; other site 273123009224 homodimer interface [polypeptide binding]; other site 273123009225 active site 273123009226 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 273123009227 AAA domain; Region: AAA_33; pfam13671 273123009228 ATP-binding site [chemical binding]; other site 273123009229 Gluconate-6-phosphate binding site [chemical binding]; other site 273123009230 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 273123009231 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 273123009232 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 273123009233 14 probable transmembrane helices predicted by TMHMM2.0 273123009234 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 273123009235 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 273123009236 14 probable transmembrane helices predicted by TMHMM2.0 273123009237 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 273123009238 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 273123009239 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 273123009240 16 probable transmembrane helices predicted by TMHMM2.0 273123009241 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 273123009242 3 probable transmembrane helices predicted by TMHMM2.0 273123009243 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 273123009244 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 273123009245 5 probable transmembrane helices predicted by TMHMM2.0 273123009246 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 273123009247 4Fe-4S binding domain; Region: Fer4; pfam00037 273123009248 4Fe-4S binding domain; Region: Fer4; pfam00037 273123009249 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 273123009250 8 probable transmembrane helices predicted by TMHMM2.0 273123009251 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 273123009252 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 273123009253 catalytic loop [active] 273123009254 iron binding site [ion binding]; other site 273123009255 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 273123009256 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 273123009257 [4Fe-4S] binding site [ion binding]; other site 273123009258 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 273123009259 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 273123009260 SLBB domain; Region: SLBB; pfam10531 273123009261 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 273123009262 NADH dehydrogenase subunit E; Validated; Region: PRK07539 273123009263 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 273123009264 putative dimer interface [polypeptide binding]; other site 273123009265 [2Fe-2S] cluster binding site [ion binding]; other site 273123009266 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 273123009267 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 273123009268 NADH dehydrogenase subunit D; Validated; Region: PRK06075 273123009269 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 273123009270 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 273123009271 3 probable transmembrane helices predicted by TMHMM2.0 273123009272 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 273123009273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123009274 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 273123009275 putative dimerization interface [polypeptide binding]; other site 273123009276 aminotransferase AlaT; Validated; Region: PRK09265 273123009277 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123009278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123009279 homodimer interface [polypeptide binding]; other site 273123009280 catalytic residue [active] 273123009281 5'-nucleotidase; Provisional; Region: PRK03826 273123009282 1 probable transmembrane helix predicted by TMHMM2.0 273123009283 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 273123009284 transmembrane helices; other site 273123009285 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 273123009286 TrkA-C domain; Region: TrkA_C; pfam02080 273123009287 TrkA-C domain; Region: TrkA_C; pfam02080 273123009288 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 273123009289 10 probable transmembrane helices predicted by TMHMM2.0 273123009290 putative phosphatase; Provisional; Region: PRK11587 273123009291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123009292 motif II; other site 273123009293 hypothetical protein; Validated; Region: PRK05445 273123009294 hypothetical protein; Provisional; Region: PRK01816 273123009295 2 probable transmembrane helices predicted by TMHMM2.0 273123009296 1 probable transmembrane helix predicted by TMHMM2.0 273123009297 propionate/acetate kinase; Provisional; Region: PRK12379 273123009298 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 273123009299 phosphate acetyltransferase; Reviewed; Region: PRK05632 273123009300 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 273123009301 DRTGG domain; Region: DRTGG; pfam07085 273123009302 phosphate acetyltransferase; Region: pta; TIGR00651 273123009303 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273123009304 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123009305 DNA binding site [nucleotide binding] 273123009306 domain linker motif; other site 273123009307 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 273123009308 putative dimerization interface [polypeptide binding]; other site 273123009309 putative ligand binding site [chemical binding]; other site 273123009310 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273123009311 active site 273123009312 phosphorylation site [posttranslational modification] 273123009313 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 273123009314 active site 273123009315 P-loop; other site 273123009316 phosphorylation site [posttranslational modification] 273123009317 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 273123009318 11 probable transmembrane helices predicted by TMHMM2.0 273123009319 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 273123009320 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 273123009321 nudix motif; other site 273123009322 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 273123009323 active site 273123009324 metal binding site [ion binding]; metal-binding site 273123009325 homotetramer interface [polypeptide binding]; other site 273123009326 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 273123009327 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 273123009328 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 273123009329 putative NAD(P) binding site [chemical binding]; other site 273123009330 putative active site [active] 273123009331 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 273123009332 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 273123009333 Walker A/P-loop; other site 273123009334 ATP binding site [chemical binding]; other site 273123009335 Q-loop/lid; other site 273123009336 ABC transporter signature motif; other site 273123009337 Walker B; other site 273123009338 D-loop; other site 273123009339 H-loop/switch region; other site 273123009340 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 273123009341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009342 dimer interface [polypeptide binding]; other site 273123009343 conserved gate region; other site 273123009344 putative PBP binding loops; other site 273123009345 ABC-ATPase subunit interface; other site 273123009346 3 probable transmembrane helices predicted by TMHMM2.0 273123009347 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 273123009348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009349 dimer interface [polypeptide binding]; other site 273123009350 conserved gate region; other site 273123009351 putative PBP binding loops; other site 273123009352 ABC-ATPase subunit interface; other site 273123009353 5 probable transmembrane helices predicted by TMHMM2.0 273123009354 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 273123009355 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123009356 substrate binding pocket [chemical binding]; other site 273123009357 membrane-bound complex binding site; other site 273123009358 hinge residues; other site 273123009359 1 probable transmembrane helix predicted by TMHMM2.0 273123009360 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 273123009361 Flavoprotein; Region: Flavoprotein; pfam02441 273123009362 amidophosphoribosyltransferase; Provisional; Region: PRK09246 273123009363 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 273123009364 active site 273123009365 tetramer interface [polypeptide binding]; other site 273123009366 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273123009367 active site 273123009368 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 273123009369 colicin V production protein; Provisional; Region: PRK10845 273123009370 4 probable transmembrane helices predicted by TMHMM2.0 273123009371 cell division protein DedD; Provisional; Region: PRK11633 273123009372 Sporulation related domain; Region: SPOR; pfam05036 273123009373 1 probable transmembrane helix predicted by TMHMM2.0 273123009374 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 273123009375 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273123009376 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 273123009377 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 273123009378 hypothetical protein; Provisional; Region: PRK10847 273123009379 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 273123009380 4 probable transmembrane helices predicted by TMHMM2.0 273123009381 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 273123009382 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 273123009383 dimerization interface 3.5A [polypeptide binding]; other site 273123009384 active site 273123009385 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 273123009386 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 273123009387 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 273123009388 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 273123009389 ligand binding site [chemical binding]; other site 273123009390 NAD binding site [chemical binding]; other site 273123009391 catalytic site [active] 273123009392 homodimer interface [polypeptide binding]; other site 273123009393 Cupin domain; Region: Cupin_2; pfam07883 273123009394 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 273123009395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123009396 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 273123009397 EamA-like transporter family; Region: EamA; cl17759 273123009398 EamA-like transporter family; Region: EamA; pfam00892 273123009399 10 probable transmembrane helices predicted by TMHMM2.0 273123009400 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 273123009401 1 probable transmembrane helix predicted by TMHMM2.0 273123009402 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 273123009403 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 273123009404 aspartate racemase; Region: asp_race; TIGR00035 273123009405 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 273123009406 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 273123009407 dimer interface [polypeptide binding]; other site 273123009408 active site 273123009409 Uncharacterized conserved protein [Function unknown]; Region: COG4121 273123009410 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 273123009411 hydroxyglutarate oxidase; Provisional; Region: PRK11728 273123009412 YfcL protein; Region: YfcL; pfam08891 273123009413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 273123009414 hypothetical protein; Provisional; Region: PRK10621 273123009415 Predicted permeases [General function prediction only]; Region: COG0730 273123009416 6 probable transmembrane helices predicted by TMHMM2.0 273123009417 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 273123009418 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 273123009419 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 273123009420 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 273123009421 Tetramer interface [polypeptide binding]; other site 273123009422 active site 273123009423 FMN-binding site [chemical binding]; other site 273123009424 HemK family putative methylases; Region: hemK_fam; TIGR00536 273123009425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123009426 S-adenosylmethionine binding site [chemical binding]; other site 273123009427 hypothetical protein; Provisional; Region: PRK04946 273123009428 Smr domain; Region: Smr; pfam01713 273123009429 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 273123009430 catalytic core [active] 273123009431 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 273123009432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 273123009433 substrate binding site [chemical binding]; other site 273123009434 oxyanion hole (OAH) forming residues; other site 273123009435 trimer interface [polypeptide binding]; other site 273123009436 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 273123009437 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 273123009438 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 273123009439 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 273123009440 dimer interface [polypeptide binding]; other site 273123009441 active site 273123009442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 273123009443 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 273123009444 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 273123009445 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 273123009446 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 273123009447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273123009448 binding surface 273123009449 TPR motif; other site 273123009450 2 probable transmembrane helices predicted by TMHMM2.0 273123009451 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 273123009452 2 probable transmembrane helices predicted by TMHMM2.0 273123009453 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 273123009454 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 273123009455 catalytic residues [active] 273123009456 central insert; other site 273123009457 1 probable transmembrane helix predicted by TMHMM2.0 273123009458 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 273123009459 15 probable transmembrane helices predicted by TMHMM2.0 273123009460 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 273123009461 1 probable transmembrane helix predicted by TMHMM2.0 273123009462 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 273123009463 1 probable transmembrane helix predicted by TMHMM2.0 273123009464 heme exporter protein CcmC; Region: ccmC; TIGR01191 273123009465 6 probable transmembrane helices predicted by TMHMM2.0 273123009466 heme exporter protein CcmB; Region: ccmB; TIGR01190 273123009467 6 probable transmembrane helices predicted by TMHMM2.0 273123009468 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 273123009469 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 273123009470 Walker A/P-loop; other site 273123009471 ATP binding site [chemical binding]; other site 273123009472 Q-loop/lid; other site 273123009473 ABC transporter signature motif; other site 273123009474 Walker B; other site 273123009475 D-loop; other site 273123009476 H-loop/switch region; other site 273123009477 1 probable transmembrane helix predicted by TMHMM2.0 273123009478 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 273123009479 1 probable transmembrane helix predicted by TMHMM2.0 273123009480 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 273123009481 5 probable transmembrane helices predicted by TMHMM2.0 273123009482 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 273123009483 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 273123009484 PhnA protein; Region: PhnA; pfam03831 273123009485 3 probable transmembrane helices predicted by TMHMM2.0 273123009486 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 273123009487 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 273123009488 ImpE protein; Region: ImpE; pfam07024 273123009489 PAAR motif; Region: PAAR_motif; pfam05488 273123009490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 273123009491 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 273123009492 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 273123009493 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 273123009494 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 273123009495 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 273123009496 5 probable transmembrane helices predicted by TMHMM2.0 273123009497 hypothetical protein; Provisional; Region: PRK08126 273123009498 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 273123009499 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 273123009500 ligand binding site [chemical binding]; other site 273123009501 1 probable transmembrane helix predicted by TMHMM2.0 273123009502 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 273123009503 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 273123009504 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 273123009505 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 273123009506 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 273123009507 Protein of unknown function (DUF877); Region: DUF877; pfam05943 273123009508 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 273123009509 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 273123009510 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 273123009511 PapC N-terminal domain; Region: PapC_N; pfam13954 273123009512 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 273123009513 PapC C-terminal domain; Region: PapC_C; pfam13953 273123009514 putative chaperone protein EcpD; Provisional; Region: PRK09926 273123009515 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 273123009516 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 273123009517 1 probable transmembrane helix predicted by TMHMM2.0 273123009518 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 273123009519 1 probable transmembrane helix predicted by TMHMM2.0 273123009520 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 273123009521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123009522 Walker A motif; other site 273123009523 ATP binding site [chemical binding]; other site 273123009524 Walker B motif; other site 273123009525 arginine finger; other site 273123009526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123009527 Walker A motif; other site 273123009528 ATP binding site [chemical binding]; other site 273123009529 Walker B motif; other site 273123009530 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 273123009531 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 273123009532 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 273123009533 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 273123009534 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 273123009535 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 273123009536 Fimbrial protein; Region: Fimbrial; pfam00419 273123009537 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 273123009538 1 probable transmembrane helix predicted by TMHMM2.0 273123009539 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 273123009540 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 273123009541 ligand binding site [chemical binding]; other site 273123009542 2 probable transmembrane helices predicted by TMHMM2.0 273123009543 Uncharacterized conserved protein [Function unknown]; Region: COG5435 273123009544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 273123009545 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123009546 DNA binding residues [nucleotide binding] 273123009547 dimerization interface [polypeptide binding]; other site 273123009548 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 273123009549 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 273123009550 N-acetyl-D-glucosamine binding site [chemical binding]; other site 273123009551 catalytic residue [active] 273123009552 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 273123009553 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 273123009554 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 273123009555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009556 dimer interface [polypeptide binding]; other site 273123009557 conserved gate region; other site 273123009558 putative PBP binding loops; other site 273123009559 ABC-ATPase subunit interface; other site 273123009560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009561 dimer interface [polypeptide binding]; other site 273123009562 conserved gate region; other site 273123009563 putative PBP binding loops; other site 273123009564 ABC-ATPase subunit interface; other site 273123009565 12 probable transmembrane helices predicted by TMHMM2.0 273123009566 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 273123009567 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 273123009568 Walker A/P-loop; other site 273123009569 ATP binding site [chemical binding]; other site 273123009570 Q-loop/lid; other site 273123009571 ABC transporter signature motif; other site 273123009572 Walker B; other site 273123009573 D-loop; other site 273123009574 H-loop/switch region; other site 273123009575 Predicted membrane protein [Function unknown]; Region: COG4331 273123009576 4 probable transmembrane helices predicted by TMHMM2.0 273123009577 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 273123009578 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 273123009579 1 probable transmembrane helix predicted by TMHMM2.0 273123009580 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 273123009581 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 273123009582 putative [Fe4-S4] binding site [ion binding]; other site 273123009583 putative molybdopterin cofactor binding site [chemical binding]; other site 273123009584 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 273123009585 putative molybdopterin cofactor binding site; other site 273123009586 1 probable transmembrane helix predicted by TMHMM2.0 273123009587 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 273123009588 4Fe-4S binding domain; Region: Fer4; cl02805 273123009589 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 273123009590 8 probable transmembrane helices predicted by TMHMM2.0 273123009591 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 273123009592 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 273123009593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 273123009594 1 probable transmembrane helix predicted by TMHMM2.0 273123009595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 273123009596 1 probable transmembrane helix predicted by TMHMM2.0 273123009597 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 273123009598 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 273123009599 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 273123009600 4 probable transmembrane helices predicted by TMHMM2.0 273123009601 aminotransferase; Validated; Region: PRK08175 273123009602 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123009603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123009604 homodimer interface [polypeptide binding]; other site 273123009605 catalytic residue [active] 273123009606 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 273123009607 glucokinase, proteobacterial type; Region: glk; TIGR00749 273123009608 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 273123009609 nucleotide binding site [chemical binding]; other site 273123009610 Predicted membrane protein [Function unknown]; Region: COG4125 273123009611 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 273123009612 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 273123009613 4 probable transmembrane helices predicted by TMHMM2.0 273123009614 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123009615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123009616 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 273123009617 dimerization interface [polypeptide binding]; other site 273123009618 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273123009619 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273123009620 active site 273123009621 catalytic tetrad [active] 273123009622 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 273123009623 manganese transport protein MntH; Reviewed; Region: PRK00701 273123009624 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 273123009625 11 probable transmembrane helices predicted by TMHMM2.0 273123009626 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 273123009627 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 273123009628 Nucleoside recognition; Region: Gate; pfam07670 273123009629 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 273123009630 10 probable transmembrane helices predicted by TMHMM2.0 273123009631 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 273123009632 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 273123009633 HIGH motif; other site 273123009634 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 273123009635 active site 273123009636 KMSKS motif; other site 273123009637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 273123009638 FlxA-like protein; Region: FlxA; pfam14282 273123009639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 273123009640 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 273123009641 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 273123009642 nucleotide binding pocket [chemical binding]; other site 273123009643 K-X-D-G motif; other site 273123009644 catalytic site [active] 273123009645 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 273123009646 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 273123009647 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 273123009648 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 273123009649 Dimer interface [polypeptide binding]; other site 273123009650 BRCT sequence motif; other site 273123009651 cell division protein ZipA; Provisional; Region: PRK03427 273123009652 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 273123009653 FtsZ protein binding site [polypeptide binding]; other site 273123009654 1 probable transmembrane helix predicted by TMHMM2.0 273123009655 putative sulfate transport protein CysZ; Validated; Region: PRK04949 273123009656 4 probable transmembrane helices predicted by TMHMM2.0 273123009657 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 273123009658 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 273123009659 dimer interface [polypeptide binding]; other site 273123009660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123009661 catalytic residue [active] 273123009662 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 273123009663 dimerization domain swap beta strand [polypeptide binding]; other site 273123009664 regulatory protein interface [polypeptide binding]; other site 273123009665 active site 273123009666 regulatory phosphorylation site [posttranslational modification]; other site 273123009667 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 273123009668 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 273123009669 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 273123009670 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 273123009671 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 273123009672 HPr interaction site; other site 273123009673 glycerol kinase (GK) interaction site [polypeptide binding]; other site 273123009674 active site 273123009675 phosphorylation site [posttranslational modification] 273123009676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123009677 dimerization interface [polypeptide binding]; other site 273123009678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123009679 dimer interface [polypeptide binding]; other site 273123009680 phosphorylation site [posttranslational modification] 273123009681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123009682 ATP binding site [chemical binding]; other site 273123009683 Mg2+ binding site [ion binding]; other site 273123009684 G-X-G motif; other site 273123009685 2 probable transmembrane helices predicted by TMHMM2.0 273123009686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273123009687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123009688 active site 273123009689 phosphorylation site [posttranslational modification] 273123009690 intermolecular recognition site; other site 273123009691 dimerization interface [polypeptide binding]; other site 273123009692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123009693 DNA binding site [nucleotide binding] 273123009694 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 273123009695 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123009696 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123009697 1 probable transmembrane helix predicted by TMHMM2.0 273123009698 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 273123009699 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 273123009700 Walker A/P-loop; other site 273123009701 ATP binding site [chemical binding]; other site 273123009702 Q-loop/lid; other site 273123009703 ABC transporter signature motif; other site 273123009704 Walker B; other site 273123009705 D-loop; other site 273123009706 H-loop/switch region; other site 273123009707 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 273123009708 FtsX-like permease family; Region: FtsX; pfam02687 273123009709 4 probable transmembrane helices predicted by TMHMM2.0 273123009710 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 273123009711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273123009712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273123009713 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273123009714 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 273123009715 active site residue [active] 273123009716 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 273123009717 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 273123009718 Na binding site [ion binding]; other site 273123009719 13 probable transmembrane helices predicted by TMHMM2.0 273123009720 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 273123009721 2 probable transmembrane helices predicted by TMHMM2.0 273123009722 putative peptidase; Provisional; Region: PRK14575 273123009723 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 273123009724 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 273123009725 active site 273123009726 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 273123009727 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123009728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123009729 homodimer interface [polypeptide binding]; other site 273123009730 catalytic residue [active] 273123009731 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 273123009732 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 273123009733 metal ion-dependent adhesion site (MIDAS); other site 273123009734 1 probable transmembrane helix predicted by TMHMM2.0 273123009735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 273123009736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123009737 dimer interface [polypeptide binding]; other site 273123009738 phosphorylation site [posttranslational modification] 273123009739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123009740 ATP binding site [chemical binding]; other site 273123009741 Mg2+ binding site [ion binding]; other site 273123009742 G-X-G motif; other site 273123009743 2 probable transmembrane helices predicted by TMHMM2.0 273123009744 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273123009745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123009746 active site 273123009747 phosphorylation site [posttranslational modification] 273123009748 intermolecular recognition site; other site 273123009749 dimerization interface [polypeptide binding]; other site 273123009750 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123009751 DNA binding site [nucleotide binding] 273123009752 Stop codon in the middle. similar to Yersinia pestis YPO3010 hypothetical protein (99.5% evalue=1.E-126); Salmonella typhimurium STM2584 gogB; Gifsy-1 prophage: leucine-rich repeat protein (45.7% evalue=8.E-41);pseudogene 273123009753 cysteine synthase B; Region: cysM; TIGR01138 273123009754 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 273123009755 dimer interface [polypeptide binding]; other site 273123009756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123009757 catalytic residue [active] 273123009758 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 273123009759 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 273123009760 Walker A/P-loop; other site 273123009761 ATP binding site [chemical binding]; other site 273123009762 Q-loop/lid; other site 273123009763 ABC transporter signature motif; other site 273123009764 Walker B; other site 273123009765 D-loop; other site 273123009766 H-loop/switch region; other site 273123009767 TOBE-like domain; Region: TOBE_3; pfam12857 273123009768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009769 dimer interface [polypeptide binding]; other site 273123009770 conserved gate region; other site 273123009771 putative PBP binding loops; other site 273123009772 ABC-ATPase subunit interface; other site 273123009773 6 probable transmembrane helices predicted by TMHMM2.0 273123009774 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 273123009775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009776 dimer interface [polypeptide binding]; other site 273123009777 conserved gate region; other site 273123009778 putative PBP binding loops; other site 273123009779 ABC-ATPase subunit interface; other site 273123009780 7 probable transmembrane helices predicted by TMHMM2.0 273123009781 thiosulfate transporter subunit; Provisional; Region: PRK10852 273123009782 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 273123009783 1 probable transmembrane helix predicted by TMHMM2.0 273123009784 putative sialic acid transporter; Provisional; Region: PRK03893 273123009785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123009786 putative substrate translocation pore; other site 273123009787 13 probable transmembrane helices predicted by TMHMM2.0 273123009788 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273123009789 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273123009790 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273123009791 putative active site [active] 273123009792 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 273123009793 N-acetylmannosamine kinase; Provisional; Region: PRK05082 273123009794 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 273123009795 nucleotide binding site [chemical binding]; other site 273123009796 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 273123009797 Leucine rich repeat; Region: LRR_8; pfam13855 273123009798 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 273123009799 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 273123009800 putative active site cavity [active] 273123009801 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 273123009802 Class I aldolases; Region: Aldolase_Class_I; cl17187 273123009803 catalytic residue [active] 273123009804 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 273123009805 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 273123009806 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 273123009807 1 probable transmembrane helix predicted by TMHMM2.0 273123009808 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 273123009809 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 273123009810 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 273123009811 Autotransporter beta-domain; Region: Autotransporter; pfam03797 273123009812 4 probable transmembrane helices predicted by TMHMM2.0 273123009813 similar to Yersinia pestis YPO3031 acetyltransferase (100% evalue=5.E-25); Salmonella typhimurium STM2449 acetyltransferase (70.9% evalue=2.E-17); acetyltransferase remnant 273123009814 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 273123009815 part of IS630 orfA;transposase 273123009816 putative acetyltransferase; Provisional; Region: PRK03624 273123009817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273123009818 Coenzyme A binding pocket [chemical binding]; other site 273123009819 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 273123009820 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 273123009821 hypothetical protein; Validated; Region: PRK00124 273123009822 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 273123009823 Malic enzyme, N-terminal domain; Region: malic; pfam00390 273123009824 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 273123009825 putative NAD(P) binding site [chemical binding]; other site 273123009826 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 273123009827 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 273123009828 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 273123009829 dimer interface [polypeptide binding]; other site 273123009830 ADP-ribose binding site [chemical binding]; other site 273123009831 active site 273123009832 nudix motif; other site 273123009833 metal binding site [ion binding]; metal-binding site 273123009834 cytochrome c-type protein NapC; Provisional; Region: PRK10617 273123009835 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 273123009836 1 probable transmembrane helix predicted by TMHMM2.0 273123009837 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 273123009838 1 probable transmembrane helix predicted by TMHMM2.0 273123009839 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 273123009840 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 273123009841 [4Fe-4S] binding site [ion binding]; other site 273123009842 molybdopterin cofactor binding site; other site 273123009843 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 273123009844 molybdopterin cofactor binding site; other site 273123009845 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 273123009846 ferredoxin-type protein; Provisional; Region: PRK10194 273123009847 transcriptional regulator NarP; Provisional; Region: PRK10403 273123009848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123009849 active site 273123009850 phosphorylation site [posttranslational modification] 273123009851 intermolecular recognition site; other site 273123009852 dimerization interface [polypeptide binding]; other site 273123009853 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123009854 DNA binding residues [nucleotide binding] 273123009855 dimerization interface [polypeptide binding]; other site 273123009856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4519 273123009857 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 273123009858 Protein export membrane protein; Region: SecD_SecF; cl14618 273123009859 Protein export membrane protein; Region: SecD_SecF; cl14618 273123009860 11 probable transmembrane helices predicted by TMHMM2.0 273123009861 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 273123009862 4 probable transmembrane helices predicted by TMHMM2.0 273123009863 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 273123009864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123009865 FeS/SAM binding site; other site 273123009866 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 273123009867 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 273123009868 Sulfatase; Region: Sulfatase; pfam00884 273123009869 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 273123009870 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 273123009871 Walker A/P-loop; other site 273123009872 ATP binding site [chemical binding]; other site 273123009873 Q-loop/lid; other site 273123009874 ABC transporter signature motif; other site 273123009875 Walker B; other site 273123009876 D-loop; other site 273123009877 H-loop/switch region; other site 273123009878 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 273123009879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009880 dimer interface [polypeptide binding]; other site 273123009881 conserved gate region; other site 273123009882 ABC-ATPase subunit interface; other site 273123009883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009884 dimer interface [polypeptide binding]; other site 273123009885 conserved gate region; other site 273123009886 putative PBP binding loops; other site 273123009887 ABC-ATPase subunit interface; other site 273123009888 14 probable transmembrane helices predicted by TMHMM2.0 273123009889 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 273123009890 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 273123009891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273123009892 TPR motif; other site 273123009893 Tetratrico peptide repeat; Region: TPR_5; pfam12688 273123009894 binding surface 273123009895 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 273123009896 ArsC family; Region: ArsC; pfam03960 273123009897 putative catalytic residues [active] 273123009898 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 273123009899 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 273123009900 metal binding site [ion binding]; metal-binding site 273123009901 dimer interface [polypeptide binding]; other site 273123009902 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 273123009903 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 273123009904 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 273123009905 1 probable transmembrane helix predicted by TMHMM2.0 273123009906 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 273123009907 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 273123009908 Helicase; Region: Helicase_RecD; pfam05127 273123009909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273123009910 Coenzyme A binding pocket [chemical binding]; other site 273123009911 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 273123009912 Predicted membrane protein [Function unknown]; Region: COG2707 273123009913 4 probable transmembrane helices predicted by TMHMM2.0 273123009914 Predicted metalloprotease [General function prediction only]; Region: COG2321 273123009915 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 273123009916 1 probable transmembrane helix predicted by TMHMM2.0 273123009917 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 273123009918 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 273123009919 ATP binding site [chemical binding]; other site 273123009920 active site 273123009921 substrate binding site [chemical binding]; other site 273123009922 lipoprotein; Provisional; Region: PRK11679 273123009923 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 273123009924 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 273123009925 dihydrodipicolinate synthase; Region: dapA; TIGR00674 273123009926 dimer interface [polypeptide binding]; other site 273123009927 active site 273123009928 catalytic residue [active] 273123009929 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 273123009930 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 273123009931 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 273123009932 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 273123009933 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 273123009934 catalytic triad [active] 273123009935 1 probable transmembrane helix predicted by TMHMM2.0 273123009936 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 273123009937 Domain of unknown function DUF20; Region: UPF0118; pfam01594 273123009938 7 probable transmembrane helices predicted by TMHMM2.0 273123009939 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 273123009940 Peptidase family M48; Region: Peptidase_M48; pfam01435 273123009941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 273123009942 TPR motif; other site 273123009943 binding surface 273123009944 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 273123009945 ArsC family; Region: ArsC; pfam03960 273123009946 catalytic residues [active] 273123009947 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 273123009948 DNA replication initiation factor; Provisional; Region: PRK08084 273123009949 uracil transporter; Provisional; Region: PRK10720 273123009950 12 probable transmembrane helices predicted by TMHMM2.0 273123009951 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273123009952 active site 273123009953 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 273123009954 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 273123009955 dimerization interface [polypeptide binding]; other site 273123009956 putative ATP binding site [chemical binding]; other site 273123009957 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 273123009958 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 273123009959 active site 273123009960 substrate binding site [chemical binding]; other site 273123009961 cosubstrate binding site; other site 273123009962 catalytic site [active] 273123009963 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 273123009964 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 273123009965 Flagellin N-methylase; Region: FliB; pfam03692 273123009966 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 273123009967 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 273123009968 Walker A/P-loop; other site 273123009969 ATP binding site [chemical binding]; other site 273123009970 Q-loop/lid; other site 273123009971 ABC transporter signature motif; other site 273123009972 Walker B; other site 273123009973 D-loop; other site 273123009974 H-loop/switch region; other site 273123009975 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 273123009976 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 273123009977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009978 dimer interface [polypeptide binding]; other site 273123009979 conserved gate region; other site 273123009980 putative PBP binding loops; other site 273123009981 ABC-ATPase subunit interface; other site 273123009982 6 probable transmembrane helices predicted by TMHMM2.0 273123009983 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 273123009984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009985 conserved gate region; other site 273123009986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123009987 dimer interface [polypeptide binding]; other site 273123009988 conserved gate region; other site 273123009989 putative PBP binding loops; other site 273123009990 ABC-ATPase subunit interface; other site 273123009991 8 probable transmembrane helices predicted by TMHMM2.0 273123009992 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 273123009993 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 273123009994 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 273123009995 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 273123009996 putative active site [active] 273123009997 catalytic site [active] 273123009998 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 273123009999 domain interface [polypeptide binding]; other site 273123010000 active site 273123010001 catalytic site [active] 273123010002 exopolyphosphatase; Provisional; Region: PRK10854 273123010003 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 273123010004 nucleotide binding site [chemical binding]; other site 273123010005 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 273123010006 1 probable transmembrane helix predicted by TMHMM2.0 273123010007 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 273123010008 MgtE intracellular N domain; Region: MgtE_N; smart00924 273123010009 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 273123010010 Divalent cation transporter; Region: MgtE; cl00786 273123010011 3 probable transmembrane helices predicted by TMHMM2.0 273123010012 putative chaperone; Provisional; Region: PRK11678 273123010013 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 273123010014 nucleotide binding site [chemical binding]; other site 273123010015 putative NEF/HSP70 interaction site [polypeptide binding]; other site 273123010016 SBD interface [polypeptide binding]; other site 273123010017 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 273123010018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123010019 dimer interface [polypeptide binding]; other site 273123010020 conserved gate region; other site 273123010021 putative PBP binding loops; other site 273123010022 ABC-ATPase subunit interface; other site 273123010023 6 probable transmembrane helices predicted by TMHMM2.0 273123010024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123010025 dimer interface [polypeptide binding]; other site 273123010026 conserved gate region; other site 273123010027 putative PBP binding loops; other site 273123010028 ABC-ATPase subunit interface; other site 273123010029 6 probable transmembrane helices predicted by TMHMM2.0 273123010030 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 273123010031 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 273123010032 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 273123010033 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 273123010034 inhibitor-cofactor binding pocket; inhibition site 273123010035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123010036 catalytic residue [active] 273123010037 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 273123010038 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123010039 DNA-binding site [nucleotide binding]; DNA binding site 273123010040 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123010041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123010042 homodimer interface [polypeptide binding]; other site 273123010043 catalytic residue [active] 273123010044 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 273123010045 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 273123010046 Walker A/P-loop; other site 273123010047 ATP binding site [chemical binding]; other site 273123010048 Q-loop/lid; other site 273123010049 ABC transporter signature motif; other site 273123010050 Walker B; other site 273123010051 D-loop; other site 273123010052 H-loop/switch region; other site 273123010053 TOBE domain; Region: TOBE_2; pfam08402 273123010054 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 273123010055 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123010056 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123010057 1 probable transmembrane helix predicted by TMHMM2.0 273123010058 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 273123010059 Protein export membrane protein; Region: SecD_SecF; cl14618 273123010060 11 probable transmembrane helices predicted by TMHMM2.0 273123010061 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 273123010062 10 probable transmembrane helices predicted by TMHMM2.0 273123010063 putative transporter; Provisional; Region: PRK10504 273123010064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123010065 putative substrate translocation pore; other site 273123010066 11 probable transmembrane helices predicted by TMHMM2.0 273123010067 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 273123010068 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123010069 dimerization interface [polypeptide binding]; other site 273123010070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123010071 dimer interface [polypeptide binding]; other site 273123010072 phosphorylation site [posttranslational modification] 273123010073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123010074 ATP binding site [chemical binding]; other site 273123010075 Mg2+ binding site [ion binding]; other site 273123010076 G-X-G motif; other site 273123010077 2 probable transmembrane helices predicted by TMHMM2.0 273123010078 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 273123010079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123010080 active site 273123010081 phosphorylation site [posttranslational modification] 273123010082 intermolecular recognition site; other site 273123010083 dimerization interface [polypeptide binding]; other site 273123010084 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123010085 DNA binding site [nucleotide binding] 273123010086 Uncharacterized conserved protein [Function unknown]; Region: COG3422 273123010087 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 273123010088 putative protease; Provisional; Region: PRK15452 273123010089 Peptidase family U32; Region: Peptidase_U32; pfam01136 273123010090 lipid kinase; Reviewed; Region: PRK13054 273123010091 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 273123010092 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 273123010093 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 273123010094 substrate binding site [chemical binding]; other site 273123010095 dimer interface [polypeptide binding]; other site 273123010096 ATP binding site [chemical binding]; other site 273123010097 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 273123010098 1 probable transmembrane helix predicted by TMHMM2.0 273123010099 2 probable transmembrane helices predicted by TMHMM2.0 273123010100 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 273123010101 3 probable transmembrane helices predicted by TMHMM2.0 273123010102 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 273123010103 3 probable transmembrane helices predicted by TMHMM2.0 273123010104 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 273123010105 3 probable transmembrane helices predicted by TMHMM2.0 273123010106 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 273123010107 3 probable transmembrane helices predicted by TMHMM2.0 273123010108 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 273123010109 GMP synthase; Reviewed; Region: guaA; PRK00074 273123010110 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 273123010111 AMP/PPi binding site [chemical binding]; other site 273123010112 candidate oxyanion hole; other site 273123010113 catalytic triad [active] 273123010114 potential glutamine specificity residues [chemical binding]; other site 273123010115 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 273123010116 ATP Binding subdomain [chemical binding]; other site 273123010117 Ligand Binding sites [chemical binding]; other site 273123010118 Dimerization subdomain; other site 273123010119 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 273123010120 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 273123010121 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 273123010122 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 273123010123 active site 273123010124 1 probable transmembrane helix predicted by TMHMM2.0 273123010125 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 273123010126 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 273123010127 generic binding surface II; other site 273123010128 generic binding surface I; other site 273123010129 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 273123010130 Predicted permeases [General function prediction only]; Region: COG0679 273123010131 10 probable transmembrane helices predicted by TMHMM2.0 273123010132 GTP-binding protein Der; Reviewed; Region: PRK00093 273123010133 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 273123010134 G1 box; other site 273123010135 GTP/Mg2+ binding site [chemical binding]; other site 273123010136 Switch I region; other site 273123010137 G2 box; other site 273123010138 Switch II region; other site 273123010139 G3 box; other site 273123010140 G4 box; other site 273123010141 G5 box; other site 273123010142 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 273123010143 G1 box; other site 273123010144 GTP/Mg2+ binding site [chemical binding]; other site 273123010145 Switch I region; other site 273123010146 G2 box; other site 273123010147 G3 box; other site 273123010148 Switch II region; other site 273123010149 G4 box; other site 273123010150 G5 box; other site 273123010151 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 273123010152 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 273123010153 Trp docking motif [polypeptide binding]; other site 273123010154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 273123010155 1 probable transmembrane helix predicted by TMHMM2.0 273123010156 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 273123010157 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 273123010158 dimer interface [polypeptide binding]; other site 273123010159 motif 1; other site 273123010160 active site 273123010161 motif 2; other site 273123010162 motif 3; other site 273123010163 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 273123010164 anticodon binding site; other site 273123010165 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 273123010166 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 273123010167 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 273123010168 cytoskeletal protein RodZ; Provisional; Region: PRK10856 273123010169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273123010170 non-specific DNA binding site [nucleotide binding]; other site 273123010171 salt bridge; other site 273123010172 sequence-specific DNA binding site [nucleotide binding]; other site 273123010173 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 273123010174 1 probable transmembrane helix predicted by TMHMM2.0 273123010175 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 273123010176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273123010177 binding surface 273123010178 TPR motif; other site 273123010179 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 273123010180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123010181 FeS/SAM binding site; other site 273123010182 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 273123010183 active site 273123010184 multimer interface [polypeptide binding]; other site 273123010185 Protein of unkown function (DUF1881); Region: DUF1881; pfam08964 273123010186 Beta/Gamma crystallin; Region: Crystall; cl02528 273123010187 Beta/Gamma crystallin; Region: Crystall; cl02528 273123010188 Exotoxin A binding; Region: Exotox-A_bind; pfam09101 273123010189 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 273123010190 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 273123010191 Autotransporter beta-domain; Region: Autotransporter; pfam03797 273123010192 1 probable transmembrane helix predicted by TMHMM2.0 273123010193 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 273123010194 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 273123010195 Autotransporter beta-domain; Region: Autotransporter; smart00869 273123010196 1 probable transmembrane helix predicted by TMHMM2.0 273123010197 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 273123010198 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 273123010199 Autotransporter beta-domain; Region: Autotransporter; pfam03797 273123010200 1 probable transmembrane helix predicted by TMHMM2.0 273123010201 SseB protein; Region: SseB; pfam07179 273123010202 aminopeptidase B; Provisional; Region: PRK05015 273123010203 Peptidase; Region: DUF3663; pfam12404 273123010204 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 273123010205 interface (dimer of trimers) [polypeptide binding]; other site 273123010206 Substrate-binding/catalytic site; other site 273123010207 Zn-binding sites [ion binding]; other site 273123010208 hypothetical protein; Provisional; Region: PRK10721 273123010209 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 273123010210 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 273123010211 catalytic loop [active] 273123010212 iron binding site [ion binding]; other site 273123010213 chaperone protein HscA; Provisional; Region: hscA; PRK05183 273123010214 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 273123010215 nucleotide binding site [chemical binding]; other site 273123010216 putative NEF/HSP70 interaction site [polypeptide binding]; other site 273123010217 SBD interface [polypeptide binding]; other site 273123010218 co-chaperone HscB; Provisional; Region: hscB; PRK05014 273123010219 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 273123010220 HSP70 interaction site [polypeptide binding]; other site 273123010221 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 273123010222 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 273123010223 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 273123010224 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 273123010225 trimerization site [polypeptide binding]; other site 273123010226 active site 273123010227 cysteine desulfurase; Provisional; Region: PRK14012 273123010228 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 273123010229 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123010230 catalytic residue [active] 273123010231 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 273123010232 Rrf2 family protein; Region: rrf2_super; TIGR00738 273123010233 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 273123010234 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 273123010235 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 273123010236 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 273123010237 active site 273123010238 dimerization interface [polypeptide binding]; other site 273123010239 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 273123010240 7 probable transmembrane helices predicted by TMHMM2.0 273123010241 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 273123010242 1 probable transmembrane helix predicted by TMHMM2.0 273123010243 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 273123010244 PRD domain; Region: PRD; pfam00874 273123010245 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 273123010246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123010247 putative substrate translocation pore; other site 273123010248 12 probable transmembrane helices predicted by TMHMM2.0 273123010249 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 273123010250 1 probable transmembrane helix predicted by TMHMM2.0 273123010251 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 273123010252 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 273123010253 dimer interface [polypeptide binding]; other site 273123010254 active site 273123010255 glycine-pyridoxal phosphate binding site [chemical binding]; other site 273123010256 folate binding site [chemical binding]; other site 273123010257 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 273123010258 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 273123010259 heme-binding site [chemical binding]; other site 273123010260 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 273123010261 FAD binding pocket [chemical binding]; other site 273123010262 FAD binding motif [chemical binding]; other site 273123010263 phosphate binding motif [ion binding]; other site 273123010264 beta-alpha-beta structure motif; other site 273123010265 NAD binding pocket [chemical binding]; other site 273123010266 Heme binding pocket [chemical binding]; other site 273123010267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123010268 DNA-binding site [nucleotide binding]; DNA binding site 273123010269 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 273123010270 Nitrogen regulatory protein P-II; Region: P-II; smart00938 273123010271 NAD synthetase; Provisional; Region: PRK13981 273123010272 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 273123010273 multimer interface [polypeptide binding]; other site 273123010274 active site 273123010275 catalytic triad [active] 273123010276 protein interface 1 [polypeptide binding]; other site 273123010277 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 273123010278 homodimer interface [polypeptide binding]; other site 273123010279 NAD binding pocket [chemical binding]; other site 273123010280 ATP binding pocket [chemical binding]; other site 273123010281 Mg binding site [ion binding]; other site 273123010282 active-site loop [active] 273123010283 response regulator GlrR; Provisional; Region: PRK15115 273123010284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123010285 active site 273123010286 phosphorylation site [posttranslational modification] 273123010287 intermolecular recognition site; other site 273123010288 dimerization interface [polypeptide binding]; other site 273123010289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123010290 Walker A motif; other site 273123010291 ATP binding site [chemical binding]; other site 273123010292 Walker B motif; other site 273123010293 arginine finger; other site 273123010294 hypothetical protein; Provisional; Region: PRK10722 273123010295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 273123010296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123010297 dimer interface [polypeptide binding]; other site 273123010298 phosphorylation site [posttranslational modification] 273123010299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123010300 ATP binding site [chemical binding]; other site 273123010301 Mg2+ binding site [ion binding]; other site 273123010302 G-X-G motif; other site 273123010303 2 probable transmembrane helices predicted by TMHMM2.0 273123010304 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 273123010305 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 273123010306 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 273123010307 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 273123010308 dimerization interface [polypeptide binding]; other site 273123010309 ATP binding site [chemical binding]; other site 273123010310 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 273123010311 dimerization interface [polypeptide binding]; other site 273123010312 ATP binding site [chemical binding]; other site 273123010313 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 273123010314 putative active site [active] 273123010315 catalytic triad [active] 273123010316 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 273123010317 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123010318 substrate binding pocket [chemical binding]; other site 273123010319 membrane-bound complex binding site; other site 273123010320 hinge residues; other site 273123010321 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 273123010322 N-acetyl-D-glucosamine binding site [chemical binding]; other site 273123010323 catalytic residue [active] 273123010324 1 probable transmembrane helix predicted by TMHMM2.0 273123010325 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 273123010326 nucleoside/Zn binding site; other site 273123010327 dimer interface [polypeptide binding]; other site 273123010328 catalytic motif [active] 273123010329 haloacid dehalogenase superfamily, subfamily IF hydrolase, YfhB; Region: YfhB_g-proteo; TIGR01545 273123010330 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 273123010331 1 probable transmembrane helix predicted by TMHMM2.0 273123010332 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 273123010333 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 273123010334 putative active site [active] 273123010335 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273123010336 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 273123010337 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273123010338 putative active site [active] 273123010339 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 273123010340 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 273123010341 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 273123010342 active site 273123010343 hydrophilic channel; other site 273123010344 dimerization interface [polypeptide binding]; other site 273123010345 catalytic residues [active] 273123010346 active site lid [active] 273123010347 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 273123010348 Recombination protein O N terminal; Region: RecO_N; pfam11967 273123010349 Recombination protein O C terminal; Region: RecO_C; pfam02565 273123010350 GTPase Era; Reviewed; Region: era; PRK00089 273123010351 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 273123010352 G1 box; other site 273123010353 GTP/Mg2+ binding site [chemical binding]; other site 273123010354 Switch I region; other site 273123010355 G2 box; other site 273123010356 Switch II region; other site 273123010357 G3 box; other site 273123010358 G4 box; other site 273123010359 G5 box; other site 273123010360 KH domain; Region: KH_2; pfam07650 273123010361 ribonuclease III; Reviewed; Region: rnc; PRK00102 273123010362 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 273123010363 dimerization interface [polypeptide binding]; other site 273123010364 active site 273123010365 metal binding site [ion binding]; metal-binding site 273123010366 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 273123010367 dsRNA binding site [nucleotide binding]; other site 273123010368 signal peptidase I; Provisional; Region: PRK10861 273123010369 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 273123010370 Catalytic site [active] 273123010371 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 273123010372 2 probable transmembrane helices predicted by TMHMM2.0 273123010373 GTP-binding protein LepA; Provisional; Region: PRK05433 273123010374 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 273123010375 G1 box; other site 273123010376 putative GEF interaction site [polypeptide binding]; other site 273123010377 GTP/Mg2+ binding site [chemical binding]; other site 273123010378 Switch I region; other site 273123010379 G2 box; other site 273123010380 G3 box; other site 273123010381 Switch II region; other site 273123010382 G4 box; other site 273123010383 G5 box; other site 273123010384 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 273123010385 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 273123010386 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 273123010387 2 probable transmembrane helices predicted by TMHMM2.0 273123010388 SoxR reducing system protein RseC; Provisional; Region: PRK10862 273123010389 2 probable transmembrane helices predicted by TMHMM2.0 273123010390 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 273123010391 anti-sigma E factor; Provisional; Region: rseB; PRK09455 273123010392 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 273123010393 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 273123010394 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 273123010395 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 273123010396 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273123010397 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273123010398 DNA binding residues [nucleotide binding] 273123010399 L-aspartate oxidase; Provisional; Region: PRK09077 273123010400 L-aspartate oxidase; Provisional; Region: PRK06175 273123010401 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 273123010402 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 273123010403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123010404 S-adenosylmethionine binding site [chemical binding]; other site 273123010405 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 273123010406 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 273123010407 ATP binding site [chemical binding]; other site 273123010408 Mg++ binding site [ion binding]; other site 273123010409 motif III; other site 273123010410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273123010411 nucleotide binding region [chemical binding]; other site 273123010412 ATP-binding site [chemical binding]; other site 273123010413 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 273123010414 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 273123010415 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 273123010416 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 273123010417 nucleophilic elbow; other site 273123010418 catalytic triad; other site 273123010419 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 273123010420 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 273123010421 ligand binding site [chemical binding]; other site 273123010422 active site 273123010423 UGI interface [polypeptide binding]; other site 273123010424 catalytic site [active] 273123010425 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 273123010426 putative substrate binding pocket [chemical binding]; other site 273123010427 AC domain interface; other site 273123010428 catalytic triad [active] 273123010429 AB domain interface; other site 273123010430 interchain disulfide; other site 273123010431 Predicted membrane protein [Function unknown]; Region: COG3817 273123010432 Protein of unknown function (DUF979); Region: DUF979; pfam06166 273123010433 9 probable transmembrane helices predicted by TMHMM2.0 273123010434 Predicted membrane protein [Function unknown]; Region: COG3819 273123010435 5 probable transmembrane helices predicted by TMHMM2.0 273123010436 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 273123010437 putative active site [active] 273123010438 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 273123010439 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 273123010440 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 273123010441 Uncharacterized conserved protein [Function unknown]; Region: COG0327 273123010442 metal-binding protein; Provisional; Region: PRK10799 273123010443 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 273123010444 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 273123010445 DNA photolyase; Region: DNA_photolyase; pfam00875 273123010446 hypothetical protein; Provisional; Region: PRK10167 273123010447 Uncharacterized conserved protein [Function unknown]; Region: COG3272 273123010448 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 273123010449 1 probable transmembrane helix predicted by TMHMM2.0 273123010450 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 273123010451 12 probable transmembrane helices predicted by TMHMM2.0 273123010452 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 273123010453 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273123010454 7 probable transmembrane helices predicted by TMHMM2.0 273123010455 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 273123010456 1 probable transmembrane helix predicted by TMHMM2.0 273123010457 sensor protein KdpD; Provisional; Region: PRK10490 273123010458 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 273123010459 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 273123010460 Ligand Binding Site [chemical binding]; other site 273123010461 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 273123010462 GAF domain; Region: GAF_3; pfam13492 273123010463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123010464 dimer interface [polypeptide binding]; other site 273123010465 phosphorylation site [posttranslational modification] 273123010466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123010467 ATP binding site [chemical binding]; other site 273123010468 Mg2+ binding site [ion binding]; other site 273123010469 G-X-G motif; other site 273123010470 3 probable transmembrane helices predicted by TMHMM2.0 273123010471 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 273123010472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123010473 active site 273123010474 phosphorylation site [posttranslational modification] 273123010475 intermolecular recognition site; other site 273123010476 dimerization interface [polypeptide binding]; other site 273123010477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123010478 DNA binding site [nucleotide binding] 273123010479 Predicted membrane protein [Function unknown]; Region: COG2510 273123010480 5 probable transmembrane helices predicted by TMHMM2.0 273123010481 phosphoglucomutase; Validated; Region: PRK07564 273123010482 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 273123010483 active site 273123010484 substrate binding site [chemical binding]; other site 273123010485 metal binding site [ion binding]; metal-binding site 273123010486 replication initiation regulator SeqA; Provisional; Region: PRK11187 273123010487 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 273123010488 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 273123010489 2 probable transmembrane helices predicted by TMHMM2.0 273123010490 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 273123010491 putative active site [active] 273123010492 YdjC motif; other site 273123010493 Mg binding site [ion binding]; other site 273123010494 putative homodimer interface [polypeptide binding]; other site 273123010495 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 273123010496 Cupin domain; Region: Cupin_2; cl17218 273123010497 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123010498 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 273123010499 methionine cluster; other site 273123010500 active site 273123010501 phosphorylation site [posttranslational modification] 273123010502 metal binding site [ion binding]; metal-binding site 273123010503 similar to Yersinia pestis YPO2679 celB; PTS system, cellobiose-specific IIC component (99.5% evalue=0); Escherichia coli b1737 celB (79.4% evalue=0);PTS system, cellobiose-specific IIC component 273123010504 9 probable transmembrane helices predicted by TMHMM2.0 273123010505 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 273123010506 active site 273123010507 P-loop; other site 273123010508 phosphorylation site [posttranslational modification] 273123010509 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 273123010510 4 probable transmembrane helices predicted by TMHMM2.0 273123010511 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636 273123010512 4 probable transmembrane helices predicted by TMHMM2.0 273123010513 voltage-gated potassium channel; Provisional; Region: PRK10537 273123010514 Ion channel; Region: Ion_trans_2; pfam07885 273123010515 TrkA-N domain; Region: TrkA_N; pfam02254 273123010516 7 probable transmembrane helices predicted by TMHMM2.0 273123010517 acid-resistance protein; Provisional; Region: hdeB; PRK11566 273123010518 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 273123010519 8 probable transmembrane helices predicted by TMHMM2.0 273123010520 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 273123010521 10 probable transmembrane helices predicted by TMHMM2.0 273123010522 UreD urease accessory protein; Region: UreD; pfam01774 273123010523 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378 273123010524 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 273123010525 UreF; Region: UreF; pfam01730 273123010526 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 273123010527 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 273123010528 dimer interface [polypeptide binding]; other site 273123010529 catalytic residues [active] 273123010530 urease subunit alpha; Reviewed; Region: ureC; PRK13309 273123010531 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 273123010532 subunit interactions [polypeptide binding]; other site 273123010533 active site 273123010534 flap region; other site 273123010535 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 273123010536 alpha-beta subunit interface [polypeptide binding]; other site 273123010537 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 273123010538 alpha-gamma subunit interface [polypeptide binding]; other site 273123010539 beta-gamma subunit interface [polypeptide binding]; other site 273123010540 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 273123010541 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123010542 Walker A/P-loop; other site 273123010543 ATP binding site [chemical binding]; other site 273123010544 Q-loop/lid; other site 273123010545 ABC transporter signature motif; other site 273123010546 Walker B; other site 273123010547 D-loop; other site 273123010548 H-loop/switch region; other site 273123010549 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123010550 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 273123010551 Walker A/P-loop; other site 273123010552 ATP binding site [chemical binding]; other site 273123010553 Q-loop/lid; other site 273123010554 ABC transporter signature motif; other site 273123010555 Walker B; other site 273123010556 D-loop; other site 273123010557 H-loop/switch region; other site 273123010558 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 273123010559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123010560 dimer interface [polypeptide binding]; other site 273123010561 conserved gate region; other site 273123010562 putative PBP binding loops; other site 273123010563 ABC-ATPase subunit interface; other site 273123010564 6 probable transmembrane helices predicted by TMHMM2.0 273123010565 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273123010566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123010567 dimer interface [polypeptide binding]; other site 273123010568 conserved gate region; other site 273123010569 putative PBP binding loops; other site 273123010570 ABC-ATPase subunit interface; other site 273123010571 5 probable transmembrane helices predicted by TMHMM2.0 273123010572 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 273123010573 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 273123010574 1 probable transmembrane helix predicted by TMHMM2.0 273123010575 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273123010576 DNA-binding site [nucleotide binding]; DNA binding site 273123010577 RNA-binding motif; other site 273123010578 MbeD/MobD like; Region: MbeD_MobD; pfam04899 273123010579 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 273123010580 1 probable transmembrane helix predicted by TMHMM2.0 273123010581 hypothetical protein; Provisional; Region: PRK10556 273123010582 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 273123010583 catalytic residues [active] 273123010584 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 273123010585 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 273123010586 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 273123010587 Class I ribonucleotide reductase; Region: RNR_I; cd01679 273123010588 active site 273123010589 dimer interface [polypeptide binding]; other site 273123010590 catalytic residues [active] 273123010591 effector binding site; other site 273123010592 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 273123010593 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 273123010594 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 273123010595 dimer interface [polypeptide binding]; other site 273123010596 putative radical transfer pathway; other site 273123010597 diiron center [ion binding]; other site 273123010598 tyrosyl radical; other site 273123010599 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 273123010600 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 273123010601 Walker A/P-loop; other site 273123010602 ATP binding site [chemical binding]; other site 273123010603 Q-loop/lid; other site 273123010604 ABC transporter signature motif; other site 273123010605 Walker B; other site 273123010606 D-loop; other site 273123010607 H-loop/switch region; other site 273123010608 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 273123010609 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 273123010610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123010611 dimer interface [polypeptide binding]; other site 273123010612 conserved gate region; other site 273123010613 putative PBP binding loops; other site 273123010614 ABC-ATPase subunit interface; other site 273123010615 6 probable transmembrane helices predicted by TMHMM2.0 273123010616 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 273123010617 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 273123010618 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 273123010619 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 273123010620 active site 273123010621 catalytic site [active] 273123010622 tetramer interface [polypeptide binding]; other site 273123010623 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 273123010624 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 273123010625 Na binding site [ion binding]; other site 273123010626 putative substrate binding site [chemical binding]; other site 273123010627 12 probable transmembrane helices predicted by TMHMM2.0 273123010628 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 273123010629 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 273123010630 active site 273123010631 catalytic site [active] 273123010632 substrate binding site [chemical binding]; other site 273123010633 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 273123010634 RNA/DNA hybrid binding site [nucleotide binding]; other site 273123010635 active site 273123010636 Methyltransferase domain; Region: Methyltransf_11; pfam08241 273123010637 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 273123010638 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 273123010639 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 273123010640 N-acetyl-D-glucosamine binding site [chemical binding]; other site 273123010641 catalytic residue [active] 273123010642 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273123010643 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273123010644 hypothetical protein; Provisional; Region: PRK05421 273123010645 putative catalytic site [active] 273123010646 putative phosphate binding site [ion binding]; other site 273123010647 putative metal binding site [ion binding]; other site 273123010648 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273123010649 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273123010650 active site 273123010651 catalytic tetrad [active] 273123010652 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 273123010653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123010654 active site 273123010655 motif I; other site 273123010656 motif II; other site 273123010657 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 273123010658 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 273123010659 Walker A/P-loop; other site 273123010660 ATP binding site [chemical binding]; other site 273123010661 Q-loop/lid; other site 273123010662 ABC transporter signature motif; other site 273123010663 Walker B; other site 273123010664 D-loop; other site 273123010665 H-loop/switch region; other site 273123010666 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 273123010667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123010668 dimer interface [polypeptide binding]; other site 273123010669 conserved gate region; other site 273123010670 ABC-ATPase subunit interface; other site 273123010671 5 probable transmembrane helices predicted by TMHMM2.0 273123010672 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 273123010673 lipoprotein, YaeC family; Region: TIGR00363 273123010674 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 273123010675 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 273123010676 homodimer interaction site [polypeptide binding]; other site 273123010677 cofactor binding site; other site 273123010678 prolyl-tRNA synthetase; Provisional; Region: PRK09194 273123010679 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 273123010680 dimer interface [polypeptide binding]; other site 273123010681 motif 1; other site 273123010682 active site 273123010683 motif 2; other site 273123010684 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 273123010685 putative deacylase active site [active] 273123010686 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 273123010687 active site 273123010688 motif 3; other site 273123010689 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 273123010690 anticodon binding site; other site 273123010691 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 273123010692 NlpE N-terminal domain; Region: NlpE; pfam04170 273123010693 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 273123010694 hypothetical protein; Provisional; Region: PRK09256 273123010695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 273123010696 hypothetical protein; Provisional; Region: PRK04964 273123010697 Rho-binding antiterminator; Provisional; Region: PRK11625 273123010698 Cytochrome c553 [Energy production and conversion]; Region: COG2863 273123010699 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 273123010700 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 273123010701 Ligand Binding Site [chemical binding]; other site 273123010702 TilS substrate binding domain; Region: TilS; pfam09179 273123010703 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 273123010704 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 273123010705 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 273123010706 putative metal binding site [ion binding]; other site 273123010707 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 273123010708 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 273123010709 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 273123010710 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 273123010711 putative active site [active] 273123010712 putative PHP Thumb interface [polypeptide binding]; other site 273123010713 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 273123010714 generic binding surface II; other site 273123010715 generic binding surface I; other site 273123010716 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 273123010717 RNA/DNA hybrid binding site [nucleotide binding]; other site 273123010718 active site 273123010719 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 273123010720 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 273123010721 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 273123010722 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 273123010723 active site 273123010724 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 273123010725 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 273123010726 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 273123010727 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 273123010728 trimer interface [polypeptide binding]; other site 273123010729 active site 273123010730 UDP-GlcNAc binding site [chemical binding]; other site 273123010731 lipid binding site [chemical binding]; lipid-binding site 273123010732 periplasmic chaperone; Provisional; Region: PRK10780 273123010733 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 273123010734 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 273123010735 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 273123010736 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 273123010737 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 273123010738 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 273123010739 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 273123010740 Surface antigen; Region: Bac_surface_Ag; pfam01103 273123010741 1 probable transmembrane helix predicted by TMHMM2.0 273123010742 zinc metallopeptidase RseP; Provisional; Region: PRK10779 273123010743 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 273123010744 active site 273123010745 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 273123010746 protein binding site [polypeptide binding]; other site 273123010747 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 273123010748 protein binding site [polypeptide binding]; other site 273123010749 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 273123010750 putative substrate binding region [chemical binding]; other site 273123010751 4 probable transmembrane helices predicted by TMHMM2.0 273123010752 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 273123010753 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 273123010754 6 probable transmembrane helices predicted by TMHMM2.0 273123010755 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 273123010756 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 273123010757 catalytic residue [active] 273123010758 putative FPP diphosphate binding site; other site 273123010759 putative FPP binding hydrophobic cleft; other site 273123010760 dimer interface [polypeptide binding]; other site 273123010761 putative IPP diphosphate binding site; other site 273123010762 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 273123010763 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 273123010764 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 273123010765 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 273123010766 ribosome recycling factor; Reviewed; Region: frr; PRK00083 273123010767 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 273123010768 hinge region; other site 273123010769 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 273123010770 putative nucleotide binding site [chemical binding]; other site 273123010771 uridine monophosphate binding site [chemical binding]; other site 273123010772 homohexameric interface [polypeptide binding]; other site 273123010773 elongation factor Ts; Provisional; Region: tsf; PRK09377 273123010774 UBA/TS-N domain; Region: UBA; pfam00627 273123010775 Elongation factor TS; Region: EF_TS; pfam00889 273123010776 Elongation factor TS; Region: EF_TS; pfam00889 273123010777 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 273123010778 rRNA interaction site [nucleotide binding]; other site 273123010779 S8 interaction site; other site 273123010780 putative laminin-1 binding site; other site 273123010781 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 273123010782 active site 273123010783 PII uridylyl-transferase; Provisional; Region: PRK05007 273123010784 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 273123010785 metal binding triad; other site 273123010786 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 273123010787 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 273123010788 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 273123010789 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 273123010790 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 273123010791 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 273123010792 trimer interface [polypeptide binding]; other site 273123010793 active site 273123010794 substrate binding site [chemical binding]; other site 273123010795 CoA binding site [chemical binding]; other site 273123010796 hypothetical protein; Provisional; Region: PRK13677 273123010797 flavodoxin; Provisional; Region: PRK08105 273123010798 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 273123010799 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 273123010800 probable active site [active] 273123010801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 273123010802 SecY interacting protein Syd; Provisional; Region: PRK04968 273123010803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 273123010804 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 273123010805 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 273123010806 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 273123010807 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 273123010808 flap endonuclease-like protein; Provisional; Region: PRK09482 273123010809 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 273123010810 active site 273123010811 metal binding site 1 [ion binding]; metal-binding site 273123010812 putative 5' ssDNA interaction site; other site 273123010813 metal binding site 3; metal-binding site 273123010814 metal binding site 2 [ion binding]; metal-binding site 273123010815 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 273123010816 putative DNA binding site [nucleotide binding]; other site 273123010817 putative metal binding site [ion binding]; other site 273123010818 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 273123010819 FtsJ-like methyltransferase; Region: FtsJ; cl17430 273123010820 hypothetical protein; Provisional; Region: PRK10873 273123010821 4 probable transmembrane helices predicted by TMHMM2.0 273123010822 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 273123010823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123010824 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 273123010825 dimerization interface [polypeptide binding]; other site 273123010826 substrate binding pocket [chemical binding]; other site 273123010827 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 273123010828 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 273123010829 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123010830 catalytic residue [active] 273123010831 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 273123010832 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 273123010833 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 273123010834 putative ATP binding site [chemical binding]; other site 273123010835 putative substrate interface [chemical binding]; other site 273123010836 1 probable transmembrane helix predicted by TMHMM2.0 273123010837 murein transglycosylase A; Provisional; Region: mltA; PRK11162 273123010838 MltA specific insert domain; Region: MltA; smart00925 273123010839 3D domain; Region: 3D; pfam06725 273123010840 AMIN domain; Region: AMIN; pfam11741 273123010841 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 273123010842 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 273123010843 active site 273123010844 metal binding site [ion binding]; metal-binding site 273123010845 N-acetylglutamate synthase; Validated; Region: PRK05279 273123010846 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 273123010847 putative feedback inhibition sensing region; other site 273123010848 putative nucleotide binding site [chemical binding]; other site 273123010849 putative substrate binding site [chemical binding]; other site 273123010850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273123010851 Coenzyme A binding pocket [chemical binding]; other site 273123010852 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 273123010853 AAA domain; Region: AAA_30; pfam13604 273123010854 Family description; Region: UvrD_C_2; pfam13538 273123010855 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 273123010856 protease3; Provisional; Region: PRK15101 273123010857 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 273123010858 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 273123010859 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 273123010860 1 probable transmembrane helix predicted by TMHMM2.0 273123010861 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 273123010862 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 273123010863 hypothetical protein; Provisional; Region: PRK10332 273123010864 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 273123010865 1 probable transmembrane helix predicted by TMHMM2.0 273123010866 Protein of unknown function (DUF2509); Region: DUF2509; pfam10713 273123010867 1 probable transmembrane helix predicted by TMHMM2.0 273123010868 hypothetical protein; Provisional; Region: PRK10557 273123010869 hypothetical protein; Provisional; Region: PRK10506 273123010870 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 273123010871 1 probable transmembrane helix predicted by TMHMM2.0 273123010872 thymidylate synthase; Reviewed; Region: thyA; PRK01827 273123010873 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 273123010874 dimerization interface [polypeptide binding]; other site 273123010875 active site 273123010876 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 273123010877 7 probable transmembrane helices predicted by TMHMM2.0 273123010878 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 273123010879 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 273123010880 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 273123010881 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 273123010882 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 273123010883 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 273123010884 putative active site [active] 273123010885 Ap4A binding site [chemical binding]; other site 273123010886 nudix motif; other site 273123010887 putative metal binding site [ion binding]; other site 273123010888 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 273123010889 putative DNA-binding cleft [nucleotide binding]; other site 273123010890 putative DNA clevage site; other site 273123010891 molecular lever; other site 273123010892 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273123010893 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273123010894 active site 273123010895 catalytic tetrad [active] 273123010896 similar to Yersinia pestis YPO1575 conserved hypothetical protein (87% evalue=1.E-07);remnant of a conserved hypothetical protein 273123010897 lysophospholipid transporter LplT; Provisional; Region: PRK11195 273123010898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123010899 putative substrate translocation pore; other site 273123010900 10 probable transmembrane helices predicted by TMHMM2.0 273123010901 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 273123010902 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 273123010903 putative acyl-acceptor binding pocket; other site 273123010904 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 273123010905 acyl-activating enzyme (AAE) consensus motif; other site 273123010906 putative AMP binding site [chemical binding]; other site 273123010907 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 273123010908 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 273123010909 molybdopterin cofactor binding site [chemical binding]; other site 273123010910 substrate binding site [chemical binding]; other site 273123010911 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 273123010912 molybdopterin cofactor binding site; other site 273123010913 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 273123010914 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123010915 DNA binding site [nucleotide binding] 273123010916 domain linker motif; other site 273123010917 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 273123010918 dimerization interface (closed form) [polypeptide binding]; other site 273123010919 ligand binding site [chemical binding]; other site 273123010920 diaminopimelate decarboxylase; Provisional; Region: PRK11165 273123010921 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 273123010922 active site 273123010923 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273123010924 substrate binding site [chemical binding]; other site 273123010925 catalytic residues [active] 273123010926 dimer interface [polypeptide binding]; other site 273123010927 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 273123010928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123010929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273123010930 dimerization interface [polypeptide binding]; other site 273123010931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123010932 putative substrate translocation pore; other site 273123010933 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273123010934 12 probable transmembrane helices predicted by TMHMM2.0 273123010935 transcriptional activator TtdR; Provisional; Region: PRK09801 273123010936 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123010937 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 273123010938 putative effector binding pocket; other site 273123010939 dimerization interface [polypeptide binding]; other site 273123010940 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 273123010941 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 273123010942 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 273123010943 catalytic residues [active] 273123010944 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 273123010945 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 273123010946 dimer interface [polypeptide binding]; other site 273123010947 ligand binding site [chemical binding]; other site 273123010948 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123010949 dimerization interface [polypeptide binding]; other site 273123010950 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 273123010951 dimer interface [polypeptide binding]; other site 273123010952 putative CheW interface [polypeptide binding]; other site 273123010953 2 probable transmembrane helices predicted by TMHMM2.0 273123010954 1 probable transmembrane helix predicted by TMHMM2.0 273123010955 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 273123010956 DNA binding site [nucleotide binding] 273123010957 1 probable transmembrane helix predicted by TMHMM2.0 273123010958 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; pfam09691 273123010959 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 273123010960 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 273123010961 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 273123010962 6 probable transmembrane helices predicted by TMHMM2.0 273123010963 1 probable transmembrane helix predicted by TMHMM2.0 273123010964 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 273123010965 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 273123010966 GspL periplasmic domain; Region: GspL_C; pfam12693 273123010967 1 probable transmembrane helix predicted by TMHMM2.0 273123010968 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 273123010969 1 probable transmembrane helix predicted by TMHMM2.0 273123010970 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 273123010971 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 273123010972 1 probable transmembrane helix predicted by TMHMM2.0 273123010973 type II secretion system protein I; Region: gspI; TIGR01707 273123010974 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 273123010975 1 probable transmembrane helix predicted by TMHMM2.0 273123010976 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 273123010977 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 273123010978 1 probable transmembrane helix predicted by TMHMM2.0 273123010979 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 273123010980 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 273123010981 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 273123010982 1 probable transmembrane helix predicted by TMHMM2.0 273123010983 type II secretion system protein F; Region: GspF; TIGR02120 273123010984 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 273123010985 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 273123010986 3 probable transmembrane helices predicted by TMHMM2.0 273123010987 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 273123010988 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 273123010989 Walker A motif; other site 273123010990 ATP binding site [chemical binding]; other site 273123010991 Walker B motif; other site 273123010992 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 273123010993 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 273123010994 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 273123010995 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 273123010996 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 273123010997 1 probable transmembrane helix predicted by TMHMM2.0 273123010998 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 273123010999 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 273123011000 1 probable transmembrane helix predicted by TMHMM2.0 273123011001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 273123011002 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 273123011003 active site clefts [active] 273123011004 zinc binding site [ion binding]; other site 273123011005 dimer interface [polypeptide binding]; other site 273123011006 1 probable transmembrane helix predicted by TMHMM2.0 273123011007 Autotransporter beta-domain; Region: Autotransporter; pfam03797 273123011008 1 probable transmembrane helix predicted by TMHMM2.0 273123011009 Lyase, N terminal; Region: Lyase_N; pfam09092 273123011010 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 273123011011 substrate binding site [chemical binding]; other site 273123011012 catalytic residues [active] 273123011013 Sulfatase; Region: Sulfatase; cl17466 273123011014 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 273123011015 1 probable transmembrane helix predicted by TMHMM2.0 273123011016 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 273123011017 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 273123011018 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 273123011019 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 273123011020 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 273123011021 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 273123011022 dimer interface [polypeptide binding]; other site 273123011023 active site 273123011024 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 273123011025 putative active site [active] 273123011026 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 273123011027 active site 273123011028 phosphorylation site [posttranslational modification] 273123011029 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 273123011030 4 probable transmembrane helices predicted by TMHMM2.0 273123011031 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 273123011032 4 probable transmembrane helices predicted by TMHMM2.0 273123011033 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 273123011034 active pocket/dimerization site; other site 273123011035 active site 273123011036 phosphorylation site [posttranslational modification] 273123011037 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 273123011038 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 273123011039 active site 273123011040 dimer interface [polypeptide binding]; other site 273123011041 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481 273123011042 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 273123011043 NADP binding site [chemical binding]; other site 273123011044 homodimer interface [polypeptide binding]; other site 273123011045 active site 273123011046 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 273123011047 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 273123011048 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123011049 FeS/SAM binding site; other site 273123011050 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 273123011051 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 273123011052 Sulfatase; Region: Sulfatase; pfam00884 273123011053 1 probable transmembrane helix predicted by TMHMM2.0 273123011054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289 273123011055 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 273123011056 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 273123011057 intersubunit interface [polypeptide binding]; other site 273123011058 active site 273123011059 zinc binding site [ion binding]; other site 273123011060 Na+ binding site [ion binding]; other site 273123011061 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 273123011062 DJ-1 family protein; Region: not_thiJ; TIGR01383 273123011063 conserved cys residue [active] 273123011064 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273123011065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123011066 DNA binding site [nucleotide binding] 273123011067 domain linker motif; other site 273123011068 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 273123011069 dimerization interface [polypeptide binding]; other site 273123011070 ligand binding site [chemical binding]; other site 273123011071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123011072 D-galactonate transporter; Region: 2A0114; TIGR00893 273123011073 putative substrate translocation pore; other site 273123011074 10 probable transmembrane helices predicted by TMHMM2.0 273123011075 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 273123011076 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 273123011077 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 273123011078 putative active site [active] 273123011079 putative catalytic site [active] 273123011080 lac repressor; Reviewed; Region: lacI; PRK09526 273123011081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123011082 DNA binding site [nucleotide binding] 273123011083 domain linker motif; other site 273123011084 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 273123011085 ligand binding site [chemical binding]; other site 273123011086 dimerization interface (open form) [polypeptide binding]; other site 273123011087 dimerization interface (closed form) [polypeptide binding]; other site 273123011088 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 273123011089 trimer interface; other site 273123011090 sugar binding site [chemical binding]; other site 273123011091 similar to Yersinia pestis YPO0851 PTS system, glucose-specific IIB component, (100% evalue=8.E-54); Salmonella typhi STY1242 ptsG; PTS system, glucose-specific IIBC component (48.8% evalue=1.E-16);C-terminal fragment of PTS transport protein. 273123011092 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 273123011093 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 273123011094 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 273123011095 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 273123011096 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 273123011097 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273123011098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123011099 dimer interface [polypeptide binding]; other site 273123011100 conserved gate region; other site 273123011101 putative PBP binding loops; other site 273123011102 ABC-ATPase subunit interface; other site 273123011103 6 probable transmembrane helices predicted by TMHMM2.0 273123011104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123011105 dimer interface [polypeptide binding]; other site 273123011106 conserved gate region; other site 273123011107 ABC-ATPase subunit interface; other site 273123011108 10 probable transmembrane helices predicted by TMHMM2.0 273123011109 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 273123011110 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 273123011111 DAK2 domain; Region: Dak2; cl03685 273123011112 1 probable transmembrane helix predicted by TMHMM2.0 273123011113 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 273123011114 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 273123011115 Walker A/P-loop; other site 273123011116 ATP binding site [chemical binding]; other site 273123011117 Q-loop/lid; other site 273123011118 ABC transporter signature motif; other site 273123011119 Walker B; other site 273123011120 D-loop; other site 273123011121 H-loop/switch region; other site 273123011122 TOBE domain; Region: TOBE; cl01440 273123011123 TOBE domain; Region: TOBE_2; pfam08402 273123011124 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123011125 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123011126 Walker A/P-loop; other site 273123011127 ATP binding site [chemical binding]; other site 273123011128 Q-loop/lid; other site 273123011129 ABC transporter signature motif; other site 273123011130 Walker B; other site 273123011131 D-loop; other site 273123011132 H-loop/switch region; other site 273123011133 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123011134 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123011135 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123011136 TM-ABC transporter signature motif; other site 273123011137 8 probable transmembrane helices predicted by TMHMM2.0 273123011138 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 273123011139 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 273123011140 putative ligand binding site [chemical binding]; other site 273123011141 1 probable transmembrane helix predicted by TMHMM2.0 273123011142 1 probable transmembrane helix predicted by TMHMM2.0 273123011143 hypothetical protein; Provisional; Region: PRK11479 273123011144 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 273123011145 Predicted transcriptional regulators [Transcription]; Region: COG1695 273123011146 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 273123011147 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 273123011148 Uncharacterized conserved protein [Function unknown]; Region: COG4104 273123011149 5 probable transmembrane helices predicted by TMHMM2.0 273123011150 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 273123011151 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 273123011152 PAAR motif; Region: PAAR_motif; pfam05488 273123011153 Pyocin large subunit [General function prediction only]; Region: COG5529 273123011154 S-type Pyocin; Region: Pyocin_S; pfam06958 273123011155 Fic family protein [Function unknown]; Region: COG3177 273123011156 Fic/DOC family; Region: Fic; pfam02661 273123011157 1 probable transmembrane helix predicted by TMHMM2.0 273123011158 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 273123011159 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 273123011160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 273123011161 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 273123011162 D5 N terminal like; Region: D5_N; smart00885 273123011163 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 273123011164 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 273123011165 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 273123011166 toxin interface [polypeptide binding]; other site 273123011167 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 273123011168 Zn binding site [ion binding]; other site 273123011169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273123011170 non-specific DNA binding site [nucleotide binding]; other site 273123011171 salt bridge; other site 273123011172 sequence-specific DNA binding site [nucleotide binding]; other site 273123011173 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 273123011174 peptide binding site [polypeptide binding]; other site 273123011175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273123011176 non-specific DNA binding site [nucleotide binding]; other site 273123011177 salt bridge; other site 273123011178 sequence-specific DNA binding site [nucleotide binding]; other site 273123011179 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 273123011180 hypothetical 273123011181 similar to Yersinia pestis YPO1091 prophage protein (44% evalue=6.E-09);Probable prophage fragment. 273123011182 integrase; Provisional; Region: int; PHA02601 273123011183 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 273123011184 active site 273123011185 DNA binding site [nucleotide binding] 273123011186 Int/Topo IB signature motif; other site 273123011187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273123011188 non-specific DNA binding site [nucleotide binding]; other site 273123011189 salt bridge; other site 273123011190 sequence-specific DNA binding site [nucleotide binding]; other site 273123011191 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 273123011192 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 273123011193 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 273123011194 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 273123011195 active site 273123011196 catalytic site [active] 273123011197 substrate binding site [chemical binding]; other site 273123011198 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 273123011199 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 273123011200 Phage-related protein [Function unknown]; Region: COG4695; cl01923 273123011201 Phage portal protein; Region: Phage_portal; pfam04860 273123011202 terminase ATPase subunit; Provisional; Region: P; PHA02535 273123011203 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 273123011204 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 273123011205 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 273123011206 terminase endonuclease subunit; Provisional; Region: M; PHA02537 273123011207 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 273123011208 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 273123011209 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 273123011210 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 273123011211 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 273123011212 Phage holin family 2; Region: Phage_holin_2; pfam04550 273123011213 3 probable transmembrane helices predicted by TMHMM2.0 273123011214 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 273123011215 1 probable transmembrane helix predicted by TMHMM2.0 273123011216 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 273123011217 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 273123011218 5 probable transmembrane helices predicted by TMHMM2.0 273123011219 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 273123011220 Baseplate J-like protein; Region: Baseplate_J; pfam04865 273123011221 1 probable transmembrane helix predicted by TMHMM2.0 273123011222 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 273123011223 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 273123011224 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 273123011225 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 273123011226 integrase; Provisional; Region: PRK09692 273123011227 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 273123011228 active site 273123011229 Int/Topo IB signature motif; other site 273123011230 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 273123011231 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 273123011232 dimer interface [polypeptide binding]; other site 273123011233 putative anticodon binding site; other site 273123011234 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 273123011235 motif 1; other site 273123011236 active site 273123011237 motif 2; other site 273123011238 motif 3; other site 273123011239 peptide chain release factor 2; Validated; Region: prfB; PRK00578 273123011240 This domain is found in peptide chain release factors; Region: PCRF; smart00937 273123011241 RF-1 domain; Region: RF-1; pfam00472 273123011242 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 273123011243 DHH family; Region: DHH; pfam01368 273123011244 DHHA1 domain; Region: DHHA1; pfam02272 273123011245 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 273123011246 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 273123011247 dimerization domain [polypeptide binding]; other site 273123011248 dimer interface [polypeptide binding]; other site 273123011249 catalytic residues [active] 273123011250 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 273123011251 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 273123011252 active site 273123011253 Int/Topo IB signature motif; other site 273123011254 flavodoxin FldB; Provisional; Region: PRK12359 273123011255 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 273123011256 6 probable transmembrane helices predicted by TMHMM2.0 273123011257 sensory histidine kinase CreC; Provisional; Region: PRK11100 273123011258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123011259 dimer interface [polypeptide binding]; other site 273123011260 phosphorylation site [posttranslational modification] 273123011261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123011262 ATP binding site [chemical binding]; other site 273123011263 Mg2+ binding site [ion binding]; other site 273123011264 G-X-G motif; other site 273123011265 2 probable transmembrane helices predicted by TMHMM2.0 273123011266 DNA-binding response regulator CreB; Provisional; Region: PRK11083 273123011267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123011268 active site 273123011269 phosphorylation site [posttranslational modification] 273123011270 intermolecular recognition site; other site 273123011271 dimerization interface [polypeptide binding]; other site 273123011272 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123011273 DNA binding site [nucleotide binding] 273123011274 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 273123011275 1 probable transmembrane helix predicted by TMHMM2.0 273123011276 hypothetical protein; Provisional; Region: PRK10878 273123011277 putative global regulator; Reviewed; Region: PRK09559 273123011278 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 273123011279 Predicted small integral membrane protein [Function unknown]; Region: COG5472 273123011280 4 probable transmembrane helices predicted by TMHMM2.0 273123011281 hemolysin; Provisional; Region: PRK15087 273123011282 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 273123011283 7 probable transmembrane helices predicted by TMHMM2.0 273123011284 1 probable transmembrane helix predicted by TMHMM2.0 273123011285 similar to Yersinia pestis YPO0902 surface protein (partial) (98.4% evalue=0); Xylella fastidiosa XF1981 surface protein (37.2% evalue=2.E-91); surface protein (partial). 273123011286 1 probable transmembrane helix predicted by TMHMM2.0 273123011287 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 273123011288 glycine dehydrogenase; Provisional; Region: PRK05367 273123011289 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 273123011290 tetramer interface [polypeptide binding]; other site 273123011291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123011292 catalytic residue [active] 273123011293 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 273123011294 tetramer interface [polypeptide binding]; other site 273123011295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123011296 catalytic residue [active] 273123011297 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 273123011298 lipoyl attachment site [posttranslational modification]; other site 273123011299 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 273123011300 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 273123011301 oxidoreductase; Provisional; Region: PRK08013 273123011302 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 273123011303 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 273123011304 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 273123011305 proline aminopeptidase P II; Provisional; Region: PRK10879 273123011306 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 273123011307 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 273123011308 active site 273123011309 hypothetical protein; Reviewed; Region: PRK01736 273123011310 Z-ring-associated protein; Provisional; Region: PRK10972 273123011311 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 273123011312 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 273123011313 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 273123011314 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 273123011315 ligand binding site [chemical binding]; other site 273123011316 NAD binding site [chemical binding]; other site 273123011317 tetramer interface [polypeptide binding]; other site 273123011318 catalytic site [active] 273123011319 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 273123011320 L-serine binding site [chemical binding]; other site 273123011321 ACT domain interface; other site 273123011322 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 273123011323 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273123011324 active site 273123011325 dimer interface [polypeptide binding]; other site 273123011326 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 273123011327 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123011328 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 273123011329 putative dimerization interface [polypeptide binding]; other site 273123011330 Uncharacterized conserved protein [Function unknown]; Region: COG2968 273123011331 oxidative stress defense protein; Provisional; Region: PRK11087 273123011332 arginine exporter protein; Provisional; Region: PRK09304 273123011333 6 probable transmembrane helices predicted by TMHMM2.0 273123011334 mechanosensitive channel MscS; Provisional; Region: PRK10334 273123011335 Conserved TM helix; Region: TM_helix; pfam05552 273123011336 Mechanosensitive ion channel; Region: MS_channel; pfam00924 273123011337 3 probable transmembrane helices predicted by TMHMM2.0 273123011338 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 273123011339 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 273123011340 active site 273123011341 intersubunit interface [polypeptide binding]; other site 273123011342 zinc binding site [ion binding]; other site 273123011343 Na+ binding site [ion binding]; other site 273123011344 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 273123011345 Phosphoglycerate kinase; Region: PGK; pfam00162 273123011346 substrate binding site [chemical binding]; other site 273123011347 hinge regions; other site 273123011348 ADP binding site [chemical binding]; other site 273123011349 catalytic site [active] 273123011350 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 273123011351 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 273123011352 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 273123011353 transketolase; Reviewed; Region: PRK12753 273123011354 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 273123011355 TPP-binding site [chemical binding]; other site 273123011356 dimer interface [polypeptide binding]; other site 273123011357 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 273123011358 PYR/PP interface [polypeptide binding]; other site 273123011359 dimer interface [polypeptide binding]; other site 273123011360 TPP binding site [chemical binding]; other site 273123011361 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 273123011362 1 probable transmembrane helix predicted by TMHMM2.0 273123011363 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 273123011364 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 273123011365 [2Fe-2S] cluster binding site [ion binding]; other site 273123011366 Transposase IS200 like; Region: Y1_Tnp; pfam01797 273123011367 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 273123011368 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 273123011369 dimer interface [polypeptide binding]; other site 273123011370 active site 273123011371 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273123011372 catalytic residues [active] 273123011373 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 273123011374 S-adenosylmethionine synthetase; Validated; Region: PRK05250 273123011375 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 273123011376 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 273123011377 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 273123011378 hypothetical protein; Provisional; Region: PRK04860 273123011379 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 273123011380 DNA-specific endonuclease I; Provisional; Region: PRK15137 273123011381 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 273123011382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 273123011383 RNA methyltransferase, RsmE family; Region: TIGR00046 273123011384 glutathione synthetase; Provisional; Region: PRK05246 273123011385 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 273123011386 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 273123011387 hypothetical protein; Validated; Region: PRK00228 273123011388 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 273123011389 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 273123011390 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 273123011391 putative active site; other site 273123011392 catalytic triad [active] 273123011393 putative dimer interface [polypeptide binding]; other site 273123011394 agmatine deiminase; Provisional; Region: PRK13551 273123011395 agmatine deiminase; Region: agmatine_aguA; TIGR03380 273123011396 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 273123011397 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 273123011398 Walker A motif; other site 273123011399 ATP binding site [chemical binding]; other site 273123011400 Walker B motif; other site 273123011401 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 273123011402 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273123011403 catalytic residue [active] 273123011404 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 273123011405 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 273123011406 YGGT family; Region: YGGT; pfam02325 273123011407 Predicted integral membrane protein [Function unknown]; Region: COG0762 273123011408 4 probable transmembrane helices predicted by TMHMM2.0 273123011409 hypothetical protein; Validated; Region: PRK05090 273123011410 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 273123011411 active site 273123011412 dimerization interface [polypeptide binding]; other site 273123011413 HemN family oxidoreductase; Provisional; Region: PRK05660 273123011414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123011415 FeS/SAM binding site; other site 273123011416 HemN C-terminal domain; Region: HemN_C; pfam06969 273123011417 Peptidase C80 family; Region: Peptidase_C80; pfam11713 273123011418 Peptidase C80 family; Region: Peptidase_C80; pfam11713 273123011419 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 273123011420 hypothetical protein; Provisional; Region: PRK10626 273123011421 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 273123011422 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 273123011423 glutaminase; Provisional; Region: PRK00971 273123011424 hypothetical protein; Provisional; Region: PRK11702 273123011425 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 273123011426 adenine DNA glycosylase; Provisional; Region: PRK10880 273123011427 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 273123011428 minor groove reading motif; other site 273123011429 helix-hairpin-helix signature motif; other site 273123011430 substrate binding pocket [chemical binding]; other site 273123011431 active site 273123011432 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 273123011433 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 273123011434 DNA binding and oxoG recognition site [nucleotide binding] 273123011435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924 273123011436 murein transglycosylase C; Provisional; Region: mltC; PRK11671 273123011437 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 273123011438 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 273123011439 N-acetyl-D-glucosamine binding site [chemical binding]; other site 273123011440 catalytic residue [active] 273123011441 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 273123011442 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 273123011443 putative ligand binding residues [chemical binding]; other site 273123011444 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 273123011445 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 273123011446 N-terminal plug; other site 273123011447 ligand-binding site [chemical binding]; other site 273123011448 1 probable transmembrane helix predicted by TMHMM2.0 273123011449 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123011450 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123011451 TM-ABC transporter signature motif; other site 273123011452 8 probable transmembrane helices predicted by TMHMM2.0 273123011453 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123011454 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123011455 Walker A/P-loop; other site 273123011456 ATP binding site [chemical binding]; other site 273123011457 Q-loop/lid; other site 273123011458 ABC transporter signature motif; other site 273123011459 Walker B; other site 273123011460 D-loop; other site 273123011461 H-loop/switch region; other site 273123011462 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123011463 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 273123011464 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 273123011465 putative ligand binding site [chemical binding]; other site 273123011466 ornithine decarboxylase; Provisional; Region: PRK13578 273123011467 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 273123011468 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 273123011469 homodimer interface [polypeptide binding]; other site 273123011470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123011471 catalytic residue [active] 273123011472 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 273123011473 similar to Yersinia pestis YPO0961 integrase (partial) (99% evalue=1.E-52); Salmonella typhi STY4666 probable phage integrase (56.8% evalue=7.E-26);Probable integrase fragment. 273123011474 similar to Yersinia pestis YPO1472 conserved hypothetical protein (91.6% evalue=3.E-98);Short fragment of conserved hypothetical protein. 273123011475 similar to Yersinia pestis YPO0963 insB; insertion sequence protein (98.3% evalue=2.E-64); Escherichia coli b1893 insB_5; insertion element IS1 protein InsB (50% evalue=3.E-30);Insertion sequence protein (partial) 273123011476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 273123011477 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 273123011478 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 273123011479 Peptidase family M23; Region: Peptidase_M23; pfam01551 273123011480 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 273123011481 similar to Yersinia pestis YPO1472 conserved hypothetical protein (97.6% evalue=4.E-89);Fragment of conserved hypothetical protein. 273123011482 similar to Yersinia pestis YPO0967a insertion sequence protein (partial) (100% evalue=1.E-64);Possible fragment of IS1 InsB like protein. 273123011483 similar to Yersinia pestis YPO0963 insB; insertion sequence protein (90.5% evalue=4.E-22);pseudogene of transposase due to frameshift 273123011484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 273123011485 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 273123011486 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 273123011487 Peptidase family M23; Region: Peptidase_M23; pfam01551 273123011488 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 273123011489 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 273123011490 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 273123011491 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 273123011492 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 273123011493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 273123011494 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 273123011495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123011496 Walker A motif; other site 273123011497 ATP binding site [chemical binding]; other site 273123011498 Walker B motif; other site 273123011499 arginine finger; other site 273123011500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123011501 Walker A motif; other site 273123011502 ATP binding site [chemical binding]; other site 273123011503 Walker B motif; other site 273123011504 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 273123011505 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 273123011506 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 273123011507 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 273123011508 ligand binding site [chemical binding]; other site 273123011509 1 probable transmembrane helix predicted by TMHMM2.0 273123011510 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 273123011511 1 probable transmembrane helix predicted by TMHMM2.0 273123011512 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 273123011513 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 273123011514 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 273123011515 Protein of unknown function (DUF877); Region: DUF877; pfam05943 273123011516 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 273123011517 hypothetical 273123011518 hypothetical 273123011519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 273123011520 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 273123011521 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 273123011522 CAAX protease self-immunity; Region: Abi; pfam02517 273123011523 6 probable transmembrane helices predicted by TMHMM2.0 273123011524 Autoinducer synthetase; Region: Autoind_synth; pfam00765 273123011525 Autoinducer binding domain; Region: Autoind_bind; pfam03472 273123011526 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123011527 DNA binding residues [nucleotide binding] 273123011528 dimerization interface [polypeptide binding]; other site 273123011529 Predicted peptidase [General function prediction only]; Region: COG4099 273123011530 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 273123011531 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 273123011532 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 273123011533 putative active site [active] 273123011534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123011535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273123011536 putative substrate translocation pore; other site 273123011537 12 probable transmembrane helices predicted by TMHMM2.0 273123011538 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 273123011539 IucA / IucC family; Region: IucA_IucC; pfam04183 273123011540 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 273123011541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 273123011542 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 273123011543 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 273123011544 IucA / IucC family; Region: IucA_IucC; pfam04183 273123011545 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 273123011546 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 273123011547 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273123011548 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 273123011549 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 273123011550 N-terminal plug; other site 273123011551 ligand-binding site [chemical binding]; other site 273123011552 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 273123011553 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 273123011554 12 probable transmembrane helices predicted by TMHMM2.0 273123011555 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 273123011556 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273123011557 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123011558 DNA binding site [nucleotide binding] 273123011559 domain linker motif; other site 273123011560 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 273123011561 putative dimerization interface [polypeptide binding]; other site 273123011562 putative ligand binding site [chemical binding]; other site 273123011563 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 273123011564 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 273123011565 transmembrane helices; other site 273123011566 14 probable transmembrane helices predicted by TMHMM2.0 273123011567 hypothetical protein; Provisional; Region: PRK10039 273123011568 HEAT repeats; Region: HEAT_2; pfam13646 273123011569 similar to Yersinia pestis YPO0762 conserved hypothetical protein (99% evalue=0); Salmonella typhi STY0324 Rhs-family protein (29.6% evalue=7.E-40);Conserved hypothetical protein (partial, C-term) 273123011570 similar to Yersinia pestis YPO3615 membrane protein (26.4% evalue=6.E-36);conserved hypothetical protein 273123011571 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 273123011572 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 273123011573 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 273123011574 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 273123011575 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 273123011576 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 273123011577 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 273123011578 RHS Repeat; Region: RHS_repeat; cl11982 273123011579 RHS Repeat; Region: RHS_repeat; pfam05593 273123011580 RHS Repeat; Region: RHS_repeat; cl11982 273123011581 RHS protein; Region: RHS; pfam03527 273123011582 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 273123011583 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 273123011584 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 273123011585 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 273123011586 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 273123011587 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 273123011588 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 273123011589 Autotransporter beta-domain; Region: Autotransporter; smart00869 273123011590 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 273123011591 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 273123011592 Autotransporter beta-domain; Region: Autotransporter; smart00869 273123011593 fructuronate transporter; Provisional; Region: PRK10034 273123011594 gluconate transporter; Region: gntP; TIGR00791 273123011595 11 probable transmembrane helices predicted by TMHMM2.0 273123011596 1 probable transmembrane helix predicted by TMHMM2.0 273123011597 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273123011598 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273123011599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123011600 Walker A/P-loop; other site 273123011601 ATP binding site [chemical binding]; other site 273123011602 Q-loop/lid; other site 273123011603 ABC transporter signature motif; other site 273123011604 Walker B; other site 273123011605 D-loop; other site 273123011606 H-loop/switch region; other site 273123011607 5 probable transmembrane helices predicted by TMHMM2.0 273123011608 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273123011609 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 273123011610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123011611 Walker A/P-loop; other site 273123011612 ATP binding site [chemical binding]; other site 273123011613 Q-loop/lid; other site 273123011614 ABC transporter signature motif; other site 273123011615 Walker B; other site 273123011616 D-loop; other site 273123011617 H-loop/switch region; other site 273123011618 6 probable transmembrane helices predicted by TMHMM2.0 273123011619 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 273123011620 muropeptide transporter; Validated; Region: ampG; cl17669 273123011621 11 probable transmembrane helices predicted by TMHMM2.0 273123011622 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 273123011623 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 273123011624 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 273123011625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273123011626 Condensation domain; Region: Condensation; pfam00668 273123011627 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 273123011628 Nonribosomal peptide synthase; Region: NRPS; pfam08415 273123011629 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 273123011630 acyl-activating enzyme (AAE) consensus motif; other site 273123011631 AMP binding site [chemical binding]; other site 273123011632 Methyltransferase domain; Region: Methyltransf_31; pfam13847 273123011633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123011634 S-adenosylmethionine binding site [chemical binding]; other site 273123011635 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 273123011636 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 273123011637 Thioesterase domain; Region: Thioesterase; pfam00975 273123011638 acyl-CoA synthetase; Validated; Region: PRK05850 273123011639 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 273123011640 acyl-activating enzyme (AAE) consensus motif; other site 273123011641 active site 273123011642 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 273123011643 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 273123011644 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 273123011645 active site 273123011646 Condensation domain; Region: Condensation; pfam00668 273123011647 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 273123011648 Nonribosomal peptide synthase; Region: NRPS; pfam08415 273123011649 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 273123011650 acyl-activating enzyme (AAE) consensus motif; other site 273123011651 AMP binding site [chemical binding]; other site 273123011652 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 273123011653 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 273123011654 Condensation domain; Region: Condensation; pfam00668 273123011655 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 273123011656 Nonribosomal peptide synthase; Region: NRPS; pfam08415 273123011657 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 273123011658 acyl-activating enzyme (AAE) consensus motif; other site 273123011659 AMP binding site [chemical binding]; other site 273123011660 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 273123011661 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 273123011662 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 273123011663 N-terminal plug; other site 273123011664 ligand-binding site [chemical binding]; other site 273123011665 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 273123011666 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 273123011667 metal binding site [ion binding]; metal-binding site 273123011668 dimer interface [polypeptide binding]; other site 273123011669 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 273123011670 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 273123011671 13 probable transmembrane helices predicted by TMHMM2.0 273123011672 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 273123011673 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 273123011674 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 273123011675 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 273123011676 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 273123011677 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 273123011678 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 273123011679 Autotransporter beta-domain; Region: Autotransporter; pfam03797 273123011680 1 probable transmembrane helix predicted by TMHMM2.0 273123011681 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 273123011682 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 273123011683 12 probable transmembrane helices predicted by TMHMM2.0 273123011684 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 273123011685 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123011686 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 273123011687 PAS domain S-box; Region: sensory_box; TIGR00229 273123011688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273123011689 putative active site [active] 273123011690 heme pocket [chemical binding]; other site 273123011691 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 273123011692 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 273123011693 metal binding site [ion binding]; metal-binding site 273123011694 active site 273123011695 I-site; other site 273123011696 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 273123011697 2 probable transmembrane helices predicted by TMHMM2.0 273123011698 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 273123011699 Helix-turn-helix domain; Region: HTH_28; pfam13518 273123011700 Helix-turn-helix domain; Region: HTH_28; pfam13518 273123011701 putative transposase OrfB; Reviewed; Region: PHA02517 273123011702 HTH-like domain; Region: HTH_21; pfam13276 273123011703 Integrase core domain; Region: rve; pfam00665 273123011704 Integrase core domain; Region: rve_2; pfam13333 273123011705 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 273123011706 MULE transposase domain; Region: MULE; pfam10551 273123011707 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 273123011708 3 probable transmembrane helices predicted by TMHMM2.0 273123011709 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 273123011710 Protein of unknown function (DUF805); Region: DUF805; pfam05656 273123011711 3 probable transmembrane helices predicted by TMHMM2.0 273123011712 4 probable transmembrane helices predicted by TMHMM2.0 273123011713 hypothetical protein; Validated; Region: PRK06778 273123011714 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 273123011715 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 273123011716 ligand binding site [chemical binding]; other site 273123011717 flagellar motor protein MotA; Provisional; Region: PRK12482 273123011718 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 273123011719 4 probable transmembrane helices predicted by TMHMM2.0 273123011720 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 273123011721 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273123011722 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 273123011723 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273123011724 DNA binding residues [nucleotide binding] 273123011725 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 273123011726 1 probable transmembrane helix predicted by TMHMM2.0 273123011727 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 273123011728 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 273123011729 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 273123011730 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 273123011731 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 273123011732 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 273123011733 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 273123011734 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 273123011735 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273123011736 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123011737 DNA binding site [nucleotide binding] 273123011738 1 probable transmembrane helix predicted by TMHMM2.0 273123011739 1 probable transmembrane helix predicted by TMHMM2.0 273123011740 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 273123011741 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 273123011742 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 273123011743 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 273123011744 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 273123011745 peptidoglycan hydrolase; Reviewed; Region: flgJ; PRK12708 273123011746 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 273123011747 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 273123011748 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 273123011749 Flagellar L-ring protein; Region: FlgH; pfam02107 273123011750 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 273123011751 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 273123011752 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 273123011753 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 273123011754 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 273123011755 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 273123011756 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 273123011757 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 273123011758 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 273123011759 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 273123011760 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 273123011761 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619 273123011762 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 273123011763 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 273123011764 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 273123011765 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 273123011766 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 273123011767 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 273123011768 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 273123011769 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 273123011770 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 273123011771 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 273123011772 FlgN protein; Region: FlgN; pfam05130 273123011773 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 273123011774 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 273123011775 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 273123011776 Walker A motif; other site 273123011777 ATP binding site [chemical binding]; other site 273123011778 Walker B motif; other site 273123011779 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 273123011780 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 273123011781 Flagellar assembly protein FliH; Region: FliH; pfam02108 273123011782 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 273123011783 MgtE intracellular N domain; Region: MgtE_N; smart00924 273123011784 FliG C-terminal domain; Region: FliG_C; pfam01706 273123011785 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 273123011786 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 273123011787 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 273123011788 2 probable transmembrane helices predicted by TMHMM2.0 273123011789 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 273123011790 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 273123011791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123011792 Walker A motif; other site 273123011793 ATP binding site [chemical binding]; other site 273123011794 Walker B motif; other site 273123011795 arginine finger; other site 273123011796 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 273123011797 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 273123011798 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 273123011799 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 273123011800 4 probable transmembrane helices predicted by TMHMM2.0 273123011801 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 273123011802 2 probable transmembrane helices predicted by TMHMM2.0 273123011803 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 273123011804 6 probable transmembrane helices predicted by TMHMM2.0 273123011805 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 273123011806 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 273123011807 3 probable transmembrane helices predicted by TMHMM2.0 273123011808 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 273123011809 FHIPEP family; Region: FHIPEP; pfam00771 273123011810 7 probable transmembrane helices predicted by TMHMM2.0 273123011811 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 273123011812 similar to Yersinia pestis YPO0702 exported protein (100% evalue=1.E-61) with a stop in the middle.;pseudogene- exported protein like 273123011813 ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592 273123011814 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 273123011815 siderophore binding site; other site 273123011816 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 273123011817 3 probable transmembrane helices predicted by TMHMM2.0 273123011818 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 273123011819 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 273123011820 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 273123011821 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 273123011822 PapC N-terminal domain; Region: PapC_N; pfam13954 273123011823 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 273123011824 PapC C-terminal domain; Region: PapC_C; pfam13953 273123011825 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 273123011826 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 273123011827 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 273123011828 active site 273123011829 Interdomain contacts; other site 273123011830 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 273123011831 Cytokine receptor motif; other site 273123011832 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 273123011833 Chitin binding domain; Region: Chitin_bind_3; pfam03067 273123011834 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 273123011835 Interdomain contacts; other site 273123011836 Cytokine receptor motif; other site 273123011837 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 273123011838 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 273123011839 Interdomain contacts; other site 273123011840 Cytokine receptor motif; other site 273123011841 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 273123011842 aromatic chitin/cellulose binding site residues [chemical binding]; other site 273123011843 similar to Salmonella typhi HCM1.219 transposase (73.4% evalue=5.E-20); Salmonella typhi HCM1.213c transposase (73.4% evalue=5.E-20);Possible transposase fragment. 273123011844 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 273123011845 1 probable transmembrane helix predicted by TMHMM2.0 273123011846 1 probable transmembrane helix predicted by TMHMM2.0 273123011847 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 273123011848 4 probable transmembrane helices predicted by TMHMM2.0 273123011849 1 probable transmembrane helix predicted by TMHMM2.0 273123011850 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 273123011851 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 273123011852 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 273123011853 1 probable transmembrane helix predicted by TMHMM2.0 273123011854 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 273123011855 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 273123011856 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 273123011857 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 273123011858 ATP binding site [chemical binding]; other site 273123011859 Walker A motif; other site 273123011860 hexamer interface [polypeptide binding]; other site 273123011861 Walker B motif; other site 273123011862 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 273123011863 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 273123011864 5 probable transmembrane helices predicted by TMHMM2.0 273123011865 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 273123011866 4 probable transmembrane helices predicted by TMHMM2.0 273123011867 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 273123011868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273123011869 binding surface 273123011870 TPR motif; other site 273123011871 1 probable transmembrane helix predicted by TMHMM2.0 273123011872 1 probable transmembrane helix predicted by TMHMM2.0 273123011873 1 probable transmembrane helix predicted by TMHMM2.0 273123011874 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 273123011875 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 273123011876 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 273123011877 metal ion-dependent adhesion site (MIDAS); other site 273123011878 1 probable transmembrane helix predicted by TMHMM2.0 273123011879 biopolymer transport protein ExbD; Provisional; Region: PRK11267 273123011880 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 273123011881 1 probable transmembrane helix predicted by TMHMM2.0 273123011882 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 273123011883 4 probable transmembrane helices predicted by TMHMM2.0 273123011884 cystathionine beta-lyase; Provisional; Region: PRK08114 273123011885 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 273123011886 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123011887 catalytic residue [active] 273123011888 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 273123011889 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 273123011890 5 probable transmembrane helices predicted by TMHMM2.0 273123011891 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 273123011892 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123011893 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 273123011894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123011895 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 273123011896 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 273123011897 dimer interface [polypeptide binding]; other site 273123011898 active site 273123011899 metal binding site [ion binding]; metal-binding site 273123011900 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273123011901 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 273123011902 active site 273123011903 catalytic tetrad [active] 273123011904 hypothetical protein; Provisional; Region: PRK01254 273123011905 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 273123011906 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 273123011907 FtsI repressor; Provisional; Region: PRK10883 273123011908 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 273123011909 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 273123011910 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 273123011911 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 273123011912 putative acyl-acceptor binding pocket; other site 273123011913 1 probable transmembrane helix predicted by TMHMM2.0 273123011914 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 273123011915 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 273123011916 CAP-like domain; other site 273123011917 active site 273123011918 primary dimer interface [polypeptide binding]; other site 273123011919 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 273123011920 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123011921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123011922 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273123011923 dimerization interface [polypeptide binding]; other site 273123011924 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 273123011925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123011926 ATP binding site [chemical binding]; other site 273123011927 Mg2+ binding site [ion binding]; other site 273123011928 G-X-G motif; other site 273123011929 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 273123011930 anchoring element; other site 273123011931 dimer interface [polypeptide binding]; other site 273123011932 ATP binding site [chemical binding]; other site 273123011933 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 273123011934 active site 273123011935 metal binding site [ion binding]; metal-binding site 273123011936 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 273123011937 esterase YqiA; Provisional; Region: PRK11071 273123011938 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 273123011939 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 273123011940 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 273123011941 active site 273123011942 metal binding site [ion binding]; metal-binding site 273123011943 hexamer interface [polypeptide binding]; other site 273123011944 putative dehydrogenase; Provisional; Region: PRK11039 273123011945 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 273123011946 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 273123011947 dimer interface [polypeptide binding]; other site 273123011948 ADP-ribose binding site [chemical binding]; other site 273123011949 active site 273123011950 nudix motif; other site 273123011951 metal binding site [ion binding]; metal-binding site 273123011952 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 273123011953 hypothetical protein; Provisional; Region: PRK11653 273123011954 1 probable transmembrane helix predicted by TMHMM2.0 273123011955 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 273123011956 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 273123011957 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 273123011958 putative active site [active] 273123011959 metal binding site [ion binding]; metal-binding site 273123011960 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 273123011961 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 273123011962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 273123011963 putative transporter; Provisional; Region: PRK11021 273123011964 11 probable transmembrane helices predicted by TMHMM2.0 273123011965 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 273123011966 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 273123011967 putative ribose interaction site [chemical binding]; other site 273123011968 putative ADP binding site [chemical binding]; other site 273123011969 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 273123011970 active site 273123011971 nucleotide binding site [chemical binding]; other site 273123011972 HIGH motif; other site 273123011973 KMSKS motif; other site 273123011974 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 273123011975 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 273123011976 metal binding triad; other site 273123011977 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 273123011978 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 273123011979 metal binding triad; other site 273123011980 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 273123011981 Uncharacterized conserved protein [Function unknown]; Region: COG3025 273123011982 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 273123011983 putative active site [active] 273123011984 putative metal binding residues [ion binding]; other site 273123011985 signature motif; other site 273123011986 putative triphosphate binding site [ion binding]; other site 273123011987 SH3 domain-containing protein; Provisional; Region: PRK10884 273123011988 Bacterial SH3 domain homologues; Region: SH3b; smart00287 273123011989 1 probable transmembrane helix predicted by TMHMM2.0 273123011990 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 273123011991 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 273123011992 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 273123011993 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273123011994 Zn2+ binding site [ion binding]; other site 273123011995 Mg2+ binding site [ion binding]; other site 273123011996 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 273123011997 8 probable transmembrane helices predicted by TMHMM2.0 273123011998 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 273123011999 homooctamer interface [polypeptide binding]; other site 273123012000 active site 273123012001 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 273123012002 5 probable transmembrane helices predicted by TMHMM2.0 273123012003 UGMP family protein; Validated; Region: PRK09604 273123012004 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 273123012005 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 273123012006 DNA primase; Validated; Region: dnaG; PRK05667 273123012007 CHC2 zinc finger; Region: zf-CHC2; pfam01807 273123012008 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 273123012009 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 273123012010 active site 273123012011 metal binding site [ion binding]; metal-binding site 273123012012 interdomain interaction site; other site 273123012013 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 273123012014 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 273123012015 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 273123012016 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 273123012017 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 273123012018 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 273123012019 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273123012020 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 273123012021 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273123012022 DNA binding residues [nucleotide binding] 273123012023 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 273123012024 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 273123012025 active site 273123012026 similar to C-t segment of : cell filamentation protein (fic)[Helicobacter pylori 26695] pir||G64664 cell filamentation protein - Helicobacter pylori (strain 26695) gb|AAD08198.1| (AE000621), E()=4.00e-06, 30% id.;Fragment of possible cell filamentation protein. 273123012027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123012028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123012029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273123012030 dimerization interface [polypeptide binding]; other site 273123012031 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 273123012032 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 273123012033 catalytic residues [active] 273123012034 putative monooxygenase; Provisional; Region: PRK11118 273123012035 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 273123012036 homotrimer interaction site [polypeptide binding]; other site 273123012037 putative active site [active] 273123012038 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 273123012039 homotrimer interaction site [polypeptide binding]; other site 273123012040 putative active site [active] 273123012041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 273123012042 YheO-like PAS domain; Region: PAS_6; pfam08348 273123012043 HTH domain; Region: HTH_22; pfam13309 273123012044 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 273123012045 putative hydrophobic ligand binding site [chemical binding]; other site 273123012046 protein interface [polypeptide binding]; other site 273123012047 gate; other site 273123012048 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 273123012049 11 probable transmembrane helices predicted by TMHMM2.0 273123012050 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 273123012051 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123012052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123012053 homodimer interface [polypeptide binding]; other site 273123012054 catalytic residue [active] 273123012055 3 probable transmembrane helices predicted by TMHMM2.0 273123012056 multidrug resistance protein MdtN; Provisional; Region: PRK10476 273123012057 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123012058 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123012059 1 probable transmembrane helix predicted by TMHMM2.0 273123012060 Predicted membrane protein [Function unknown]; Region: COG1289 273123012061 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 273123012062 9 probable transmembrane helices predicted by TMHMM2.0 273123012063 Outer membrane efflux protein; Region: OEP; pfam02321 273123012064 Outer membrane efflux protein; Region: OEP; pfam02321 273123012065 1 probable transmembrane helix predicted by TMHMM2.0 273123012066 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 273123012067 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 273123012068 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 273123012069 1 probable transmembrane helix predicted by TMHMM2.0 273123012070 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273123012071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123012072 dimer interface [polypeptide binding]; other site 273123012073 conserved gate region; other site 273123012074 putative PBP binding loops; other site 273123012075 ABC-ATPase subunit interface; other site 273123012076 6 probable transmembrane helices predicted by TMHMM2.0 273123012077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123012078 dimer interface [polypeptide binding]; other site 273123012079 conserved gate region; other site 273123012080 putative PBP binding loops; other site 273123012081 ABC-ATPase subunit interface; other site 273123012082 6 probable transmembrane helices predicted by TMHMM2.0 273123012083 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 273123012084 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 273123012085 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273123012086 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123012087 DNA binding site [nucleotide binding] 273123012088 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 273123012089 ligand binding site [chemical binding]; other site 273123012090 dimerization interface [polypeptide binding]; other site 273123012091 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 273123012092 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 273123012093 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 273123012094 Walker A/P-loop; other site 273123012095 ATP binding site [chemical binding]; other site 273123012096 Q-loop/lid; other site 273123012097 ABC transporter signature motif; other site 273123012098 Walker B; other site 273123012099 D-loop; other site 273123012100 H-loop/switch region; other site 273123012101 TOBE domain; Region: TOBE_2; pfam08402 273123012102 Putative glucoamylase; Region: Glycoamylase; pfam10091 273123012103 1 probable transmembrane helix predicted by TMHMM2.0 273123012104 Autotransporter beta-domain; Region: Autotransporter; smart00869 273123012105 similar to Yersinia pestis YPO2490 hemolysin (72.5% evalue=3.E-43); adhesin 273123012106 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 273123012107 similar to Yersinia pestis YPO2490 hemolysin (58.6% evalue=1.E-139);Fragment of hemagglutinin/hemolysin-related protein 273123012108 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 273123012109 similar to Yersinia pestis YPO2490 hemolysin (68.6% evalue=0);fragment of hemagglutinin/hemolysin-related protein 273123012110 similar to Yersinia pestis YPO2490 hemolysin (65.9% evalue=0);fragment of hemagglutinin/hemolysin-related protein 273123012111 similar to Yersinia pestis YPO2486 conserved hypothetical protein (66.2% evalue=5.E-73);hypothetical protein 273123012112 haemagglutination activity domain; Region: Haemagg_act; pfam05860 273123012113 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 273123012114 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123012115 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123012116 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123012117 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 273123012118 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 273123012119 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 273123012120 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 273123012121 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 273123012122 metal ion-dependent adhesion site (MIDAS); other site 273123012123 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 273123012124 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 273123012125 putative metal binding site [ion binding]; other site 273123012126 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 273123012127 metal ion-dependent adhesion site (MIDAS); other site 273123012128 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 273123012129 metal ion-dependent adhesion site (MIDAS); other site 273123012130 Protein phosphatase 2C; Region: PP2C_2; pfam13672 273123012131 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 273123012132 substrate binding site [chemical binding]; other site 273123012133 activation loop (A-loop); other site 273123012134 acid-resistance membrane protein; Provisional; Region: PRK10209 273123012135 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 273123012136 6 probable transmembrane helices predicted by TMHMM2.0 273123012137 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 273123012138 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 273123012139 active site 273123012140 FMN binding site [chemical binding]; other site 273123012141 2,4-decadienoyl-CoA binding site; other site 273123012142 catalytic residue [active] 273123012143 4Fe-4S cluster binding site [ion binding]; other site 273123012144 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 273123012145 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 273123012146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123012147 S-adenosylmethionine binding site [chemical binding]; other site 273123012148 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 273123012149 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 273123012150 Autotransporter beta-domain; Region: Autotransporter; pfam03797 273123012151 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 273123012152 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273123012153 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 273123012154 serine/threonine transporter SstT; Provisional; Region: PRK13628 273123012155 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 273123012156 8 probable transmembrane helices predicted by TMHMM2.0 273123012157 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 273123012158 5 probable transmembrane helices predicted by TMHMM2.0 273123012159 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 273123012160 galactarate dehydratase; Region: galactar-dH20; TIGR03248 273123012161 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 273123012162 altronate oxidoreductase; Provisional; Region: PRK03643 273123012163 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 273123012164 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 273123012165 Glucuronate isomerase; Region: UxaC; pfam02614 273123012166 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 273123012167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123012168 D-galactonate transporter; Region: 2A0114; TIGR00893 273123012169 putative substrate translocation pore; other site 273123012170 11 probable transmembrane helices predicted by TMHMM2.0 273123012171 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 273123012172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123012173 DNA-binding site [nucleotide binding]; DNA binding site 273123012174 FCD domain; Region: FCD; pfam07729 273123012175 1 probable transmembrane helix predicted by TMHMM2.0 273123012176 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 273123012177 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 273123012178 5 probable transmembrane helices predicted by TMHMM2.0 273123012179 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 273123012180 1 probable transmembrane helix predicted by TMHMM2.0 273123012181 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 273123012182 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 273123012183 1 probable transmembrane helix predicted by TMHMM2.0 273123012184 Predicted membrane protein [Function unknown]; Region: COG5393 273123012185 2 probable transmembrane helices predicted by TMHMM2.0 273123012186 YqjK-like protein; Region: YqjK; pfam13997 273123012187 Predicted membrane protein [Function unknown]; Region: COG2259 273123012188 4 probable transmembrane helices predicted by TMHMM2.0 273123012189 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 273123012190 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 273123012191 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 273123012192 putative dimer interface [polypeptide binding]; other site 273123012193 N-terminal domain interface [polypeptide binding]; other site 273123012194 putative substrate binding pocket (H-site) [chemical binding]; other site 273123012195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123012196 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 273123012197 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273123012198 dimerization interface [polypeptide binding]; other site 273123012199 Pirin-related protein [General function prediction only]; Region: COG1741 273123012200 Pirin; Region: Pirin; pfam02678 273123012201 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 273123012202 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 273123012203 putative SAM binding site [chemical binding]; other site 273123012204 putative homodimer interface [polypeptide binding]; other site 273123012205 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 273123012206 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 273123012207 putative ligand binding site [chemical binding]; other site 273123012208 hypothetical protein; Reviewed; Region: PRK12497 273123012209 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 273123012210 dimer interface [polypeptide binding]; other site 273123012211 active site 273123012212 outer membrane lipoprotein; Provisional; Region: PRK11023 273123012213 BON domain; Region: BON; pfam04972 273123012214 BON domain; Region: BON; cl02771 273123012215 1 probable transmembrane helix predicted by TMHMM2.0 273123012216 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 273123012217 Transglycosylase; Region: Transgly; cl17702 273123012218 1 probable transmembrane helix predicted by TMHMM2.0 273123012219 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 273123012220 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 273123012221 conserved cys residue [active] 273123012222 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 273123012223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273123012224 putative active site [active] 273123012225 heme pocket [chemical binding]; other site 273123012226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123012227 dimer interface [polypeptide binding]; other site 273123012228 phosphorylation site [posttranslational modification] 273123012229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123012230 ATP binding site [chemical binding]; other site 273123012231 Mg2+ binding site [ion binding]; other site 273123012232 G-X-G motif; other site 273123012233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123012234 active site 273123012235 phosphorylation site [posttranslational modification] 273123012236 intermolecular recognition site; other site 273123012237 dimerization interface [polypeptide binding]; other site 273123012238 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 273123012239 putative binding surface; other site 273123012240 active site 273123012241 2 probable transmembrane helices predicted by TMHMM2.0 273123012242 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 273123012243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273123012244 FeS/SAM binding site; other site 273123012245 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 273123012246 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 273123012247 active site 273123012248 dimer interface [polypeptide binding]; other site 273123012249 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 273123012250 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 273123012251 active site 273123012252 FMN binding site [chemical binding]; other site 273123012253 substrate binding site [chemical binding]; other site 273123012254 3Fe-4S cluster binding site [ion binding]; other site 273123012255 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 273123012256 domain interface; other site 273123012257 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 273123012258 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273123012259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 273123012260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273123012261 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 273123012262 stringent starvation protein A; Provisional; Region: sspA; PRK09481 273123012263 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 273123012264 C-terminal domain interface [polypeptide binding]; other site 273123012265 putative GSH binding site (G-site) [chemical binding]; other site 273123012266 dimer interface [polypeptide binding]; other site 273123012267 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 273123012268 dimer interface [polypeptide binding]; other site 273123012269 N-terminal domain interface [polypeptide binding]; other site 273123012270 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 273123012271 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 273123012272 23S rRNA interface [nucleotide binding]; other site 273123012273 L3 interface [polypeptide binding]; other site 273123012274 Predicted ATPase [General function prediction only]; Region: COG1485 273123012275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 273123012276 hypothetical protein; Provisional; Region: PRK11677 273123012277 1 probable transmembrane helix predicted by TMHMM2.0 273123012278 serine endoprotease; Provisional; Region: PRK10139 273123012279 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 273123012280 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 273123012281 protein binding site [polypeptide binding]; other site 273123012282 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 273123012283 1 probable transmembrane helix predicted by TMHMM2.0 273123012284 serine endoprotease; Provisional; Region: PRK10898 273123012285 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 273123012286 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 273123012287 protein binding site [polypeptide binding]; other site 273123012288 1 probable transmembrane helix predicted by TMHMM2.0 273123012289 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 273123012290 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 273123012291 hinge; other site 273123012292 active site 273123012293 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 273123012294 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 273123012295 anti sigma factor interaction site; other site 273123012296 regulatory phosphorylation site [posttranslational modification]; other site 273123012297 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 273123012298 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 273123012299 mce related protein; Region: MCE; pfam02470 273123012300 1 probable transmembrane helix predicted by TMHMM2.0 273123012301 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 273123012302 conserved hypothetical integral membrane protein; Region: TIGR00056 273123012303 5 probable transmembrane helices predicted by TMHMM2.0 273123012304 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 273123012305 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 273123012306 Walker A/P-loop; other site 273123012307 ATP binding site [chemical binding]; other site 273123012308 Q-loop/lid; other site 273123012309 ABC transporter signature motif; other site 273123012310 Walker B; other site 273123012311 D-loop; other site 273123012312 H-loop/switch region; other site 273123012313 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 273123012314 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 273123012315 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 273123012316 9 probable transmembrane helices predicted by TMHMM2.0 273123012317 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 273123012318 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 273123012319 putative active site [active] 273123012320 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 273123012321 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 273123012322 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 273123012323 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 273123012324 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 273123012325 1 probable transmembrane helix predicted by TMHMM2.0 273123012326 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 273123012327 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 273123012328 1 probable transmembrane helix predicted by TMHMM2.0 273123012329 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 273123012330 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 273123012331 Walker A/P-loop; other site 273123012332 ATP binding site [chemical binding]; other site 273123012333 Q-loop/lid; other site 273123012334 ABC transporter signature motif; other site 273123012335 Walker B; other site 273123012336 D-loop; other site 273123012337 H-loop/switch region; other site 273123012338 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 273123012339 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 273123012340 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 273123012341 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 273123012342 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 273123012343 30S subunit binding site; other site 273123012344 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273123012345 active site 273123012346 phosphorylation site [posttranslational modification] 273123012347 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 273123012348 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 273123012349 dimerization domain swap beta strand [polypeptide binding]; other site 273123012350 regulatory protein interface [polypeptide binding]; other site 273123012351 active site 273123012352 regulatory phosphorylation site [posttranslational modification]; other site 273123012353 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 273123012354 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 273123012355 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 273123012356 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 273123012357 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 273123012358 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 273123012359 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 273123012360 homotrimer interaction site [polypeptide binding]; other site 273123012361 putative active site [active] 273123012362 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 273123012363 dimer interface [polypeptide binding]; other site 273123012364 putative inhibitory loop; other site 273123012365 trehalose repressor; Provisional; Region: treR; PRK09492 273123012366 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123012367 DNA binding site [nucleotide binding] 273123012368 domain linker motif; other site 273123012369 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 273123012370 dimerization interface [polypeptide binding]; other site 273123012371 ligand binding site [chemical binding]; other site 273123012372 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 273123012373 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 273123012374 active site turn [active] 273123012375 phosphorylation site [posttranslational modification] 273123012376 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 273123012377 10 probable transmembrane helices predicted by TMHMM2.0 273123012378 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 273123012379 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 273123012380 Ca binding site [ion binding]; other site 273123012381 active site 273123012382 catalytic site [active] 273123012383 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 273123012384 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 273123012385 Soluble cytochrome b562 [Energy production and conversion]; Region: CybC; COG3783 273123012386 1 probable transmembrane helix predicted by TMHMM2.0 273123012387 similar to Yersinia pestis YPO3693 hypothetical protein (100% evalue=1.E-119);conserved hypothetical protein 273123012388 peptidase PmbA; Provisional; Region: PRK11040 273123012389 hypothetical protein; Provisional; Region: PRK05255 273123012390 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 273123012391 RNAase interaction site [polypeptide binding]; other site 273123012392 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 273123012393 active site 273123012394 1 probable transmembrane helix predicted by TMHMM2.0 273123012395 succinic semialdehyde dehydrogenase; Region: PLN02278 273123012396 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 273123012397 tetramerization interface [polypeptide binding]; other site 273123012398 NAD(P) binding site [chemical binding]; other site 273123012399 catalytic residues [active] 273123012400 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 273123012401 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 273123012402 10 probable transmembrane helices predicted by TMHMM2.0 273123012403 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 273123012404 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 273123012405 HlyD family secretion protein; Region: HlyD_3; pfam13437 273123012406 1 probable transmembrane helix predicted by TMHMM2.0 273123012407 efflux system membrane protein; Provisional; Region: PRK11594 273123012408 2 probable transmembrane helices predicted by TMHMM2.0 273123012409 transcriptional regulator; Provisional; Region: PRK10632 273123012410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123012411 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 273123012412 putative effector binding pocket; other site 273123012413 dimerization interface [polypeptide binding]; other site 273123012414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 273123012415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 273123012416 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 273123012417 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 273123012418 Family description; Region: VCBS; pfam13517 273123012419 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 273123012420 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 273123012421 3 probable transmembrane helices predicted by TMHMM2.0 273123012422 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 273123012423 1 probable transmembrane helix predicted by TMHMM2.0 273123012424 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 273123012425 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 273123012426 protease TldD; Provisional; Region: tldD; PRK10735 273123012427 nitrilase; Region: PLN02798 273123012428 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 273123012429 putative active site [active] 273123012430 catalytic triad [active] 273123012431 dimer interface [polypeptide binding]; other site 273123012432 hypothetical protein; Provisional; Region: PRK10899 273123012433 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 273123012434 1 probable transmembrane helix predicted by TMHMM2.0 273123012435 ribonuclease G; Provisional; Region: PRK11712 273123012436 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 273123012437 homodimer interface [polypeptide binding]; other site 273123012438 oligonucleotide binding site [chemical binding]; other site 273123012439 Maf-like protein; Region: Maf; pfam02545 273123012440 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 273123012441 active site 273123012442 dimer interface [polypeptide binding]; other site 273123012443 rod shape-determining protein MreD; Provisional; Region: PRK11060 273123012444 5 probable transmembrane helices predicted by TMHMM2.0 273123012445 rod shape-determining protein MreC; Region: mreC; TIGR00219 273123012446 rod shape-determining protein MreC; Region: MreC; pfam04085 273123012447 1 probable transmembrane helix predicted by TMHMM2.0 273123012448 rod shape-determining protein MreB; Provisional; Region: PRK13927 273123012449 MreB and similar proteins; Region: MreB_like; cd10225 273123012450 nucleotide binding site [chemical binding]; other site 273123012451 Mg binding site [ion binding]; other site 273123012452 putative protofilament interaction site [polypeptide binding]; other site 273123012453 RodZ interaction site [polypeptide binding]; other site 273123012454 regulatory protein CsrD; Provisional; Region: PRK11059 273123012455 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 273123012456 metal binding site [ion binding]; metal-binding site 273123012457 active site 273123012458 I-site; other site 273123012459 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 273123012460 2 probable transmembrane helices predicted by TMHMM2.0 273123012461 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 273123012462 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 273123012463 NADP binding site [chemical binding]; other site 273123012464 dimer interface [polypeptide binding]; other site 273123012465 TMAO/DMSO reductase; Reviewed; Region: PRK05363 273123012466 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 273123012467 Moco binding site; other site 273123012468 metal coordination site [ion binding]; other site 273123012469 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 273123012470 6 probable transmembrane helices predicted by TMHMM2.0 273123012471 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 273123012472 Dehydroquinase class II; Region: DHquinase_II; pfam01220 273123012473 active site 273123012474 trimer interface [polypeptide binding]; other site 273123012475 dimer interface [polypeptide binding]; other site 273123012476 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 273123012477 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 273123012478 carboxyltransferase (CT) interaction site; other site 273123012479 biotinylation site [posttranslational modification]; other site 273123012480 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 273123012481 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 273123012482 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 273123012483 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 273123012484 hypothetical protein; Provisional; Region: PRK10633 273123012485 2 probable transmembrane helices predicted by TMHMM2.0 273123012486 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 273123012487 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 273123012488 Na binding site [ion binding]; other site 273123012489 13 probable transmembrane helices predicted by TMHMM2.0 273123012490 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 273123012491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 273123012492 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 273123012493 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 273123012494 FMN binding site [chemical binding]; other site 273123012495 active site 273123012496 catalytic residues [active] 273123012497 substrate binding site [chemical binding]; other site 273123012498 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 273123012499 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 273123012500 Transcriptional regulators [Transcription]; Region: GntR; COG1802 273123012501 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273123012502 DNA-binding site [nucleotide binding]; DNA binding site 273123012503 FCD domain; Region: FCD; pfam07729 273123012504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123012505 metabolite-proton symporter; Region: 2A0106; TIGR00883 273123012506 putative substrate translocation pore; other site 273123012507 12 probable transmembrane helices predicted by TMHMM2.0 273123012508 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 273123012509 1 probable transmembrane helix predicted by TMHMM2.0 273123012510 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 273123012511 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 273123012512 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 273123012513 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 273123012514 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273123012515 DNA-binding site [nucleotide binding]; DNA binding site 273123012516 RNA-binding motif; other site 273123012517 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273123012518 DNA-binding site [nucleotide binding]; DNA binding site 273123012519 RNA-binding motif; other site 273123012520 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 273123012521 DNA-binding site [nucleotide binding]; DNA binding site 273123012522 RNA-binding motif; other site 273123012523 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 273123012524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 273123012525 putative S-transferase; Provisional; Region: PRK11752 273123012526 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 273123012527 C-terminal domain interface [polypeptide binding]; other site 273123012528 GSH binding site (G-site) [chemical binding]; other site 273123012529 dimer interface [polypeptide binding]; other site 273123012530 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 273123012531 dimer interface [polypeptide binding]; other site 273123012532 N-terminal domain interface [polypeptide binding]; other site 273123012533 active site 273123012534 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 273123012535 putative active site [active] 273123012536 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 273123012537 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 273123012538 N- and C-terminal domain interface [polypeptide binding]; other site 273123012539 active site 273123012540 MgATP binding site [chemical binding]; other site 273123012541 catalytic site [active] 273123012542 metal binding site [ion binding]; metal-binding site 273123012543 carbohydrate binding site [chemical binding]; other site 273123012544 putative homodimer interface [polypeptide binding]; other site 273123012545 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123012546 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123012547 TM-ABC transporter signature motif; other site 273123012548 8 probable transmembrane helices predicted by TMHMM2.0 273123012549 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123012550 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123012551 TM-ABC transporter signature motif; other site 273123012552 10 probable transmembrane helices predicted by TMHMM2.0 273123012553 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123012554 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123012555 Walker A/P-loop; other site 273123012556 ATP binding site [chemical binding]; other site 273123012557 Q-loop/lid; other site 273123012558 ABC transporter signature motif; other site 273123012559 Walker B; other site 273123012560 D-loop; other site 273123012561 H-loop/switch region; other site 273123012562 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123012563 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 273123012564 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 273123012565 ligand binding site [chemical binding]; other site 273123012566 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 273123012567 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 273123012568 putative acyl-acceptor binding pocket; other site 273123012569 1 probable transmembrane helix predicted by TMHMM2.0 273123012570 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 273123012571 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 273123012572 11 probable transmembrane helices predicted by TMHMM2.0 273123012573 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 273123012574 13 probable transmembrane helices predicted by TMHMM2.0 273123012575 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 273123012576 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 273123012577 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 273123012578 Walker A/P-loop; other site 273123012579 ATP binding site [chemical binding]; other site 273123012580 Q-loop/lid; other site 273123012581 ABC transporter signature motif; other site 273123012582 Walker B; other site 273123012583 D-loop; other site 273123012584 H-loop/switch region; other site 273123012585 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 273123012586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123012587 dimer interface [polypeptide binding]; other site 273123012588 conserved gate region; other site 273123012589 putative PBP binding loops; other site 273123012590 ABC-ATPase subunit interface; other site 273123012591 7 probable transmembrane helices predicted by TMHMM2.0 273123012592 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 273123012593 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 273123012594 active site 273123012595 dimer interface [polypeptide binding]; other site 273123012596 non-prolyl cis peptide bond; other site 273123012597 insertion regions; other site 273123012598 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123012599 substrate binding pocket [chemical binding]; other site 273123012600 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 273123012601 membrane-bound complex binding site; other site 273123012602 hinge residues; other site 273123012603 1 probable transmembrane helix predicted by TMHMM2.0 273123012604 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 273123012605 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 273123012606 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 273123012607 intersubunit interface [polypeptide binding]; other site 273123012608 active site 273123012609 catalytic residue [active] 273123012610 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 273123012611 substrate binding site [chemical binding]; other site 273123012612 dimer interface [polypeptide binding]; other site 273123012613 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 273123012614 ATP binding site [chemical binding]; other site 273123012615 ABC-type ribose transport system, auxiliary component [Carbohydrate transport and metabolism]; Region: RbsD; COG1869 273123012616 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 273123012617 Helix-turn-helix domain; Region: HTH_18; pfam12833 273123012618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123012619 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273123012620 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 273123012621 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 273123012622 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 273123012623 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 273123012624 AP (apurinic/apyrimidinic) site pocket; other site 273123012625 DNA interaction; other site 273123012626 Metal-binding active site; metal-binding site 273123012627 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 273123012628 PAAR motif; Region: PAAR_motif; pfam05488 273123012629 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 273123012630 RHS Repeat; Region: RHS_repeat; pfam05593 273123012631 RHS Repeat; Region: RHS_repeat; cl11982 273123012632 RHS Repeat; Region: RHS_repeat; pfam05593 273123012633 RHS Repeat; Region: RHS_repeat; pfam05593 273123012634 RHS Repeat; Region: RHS_repeat; cl11982 273123012635 RHS protein; Region: RHS; pfam03527 273123012636 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 273123012637 3 probable transmembrane helices predicted by TMHMM2.0 273123012638 Uncharacterized conserved protein [Function unknown]; Region: COG5435 273123012639 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 273123012640 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 273123012641 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 273123012642 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 273123012643 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 273123012644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273123012645 non-specific DNA binding site [nucleotide binding]; other site 273123012646 salt bridge; other site 273123012647 sequence-specific DNA binding site [nucleotide binding]; other site 273123012648 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 273123012649 PAAR motif; Region: PAAR_motif; pfam05488 273123012650 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 273123012651 RHS Repeat; Region: RHS_repeat; pfam05593 273123012652 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 273123012653 RHS Repeat; Region: RHS_repeat; pfam05593 273123012654 RHS Repeat; Region: RHS_repeat; cl11982 273123012655 RHS protein; Region: RHS; pfam03527 273123012656 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 273123012657 2 probable transmembrane helices predicted by TMHMM2.0 273123012658 Uncharacterized conserved protein [Function unknown]; Region: COG5435 273123012659 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 273123012660 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 273123012661 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 273123012662 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 273123012663 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 273123012664 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 273123012665 ImpA domain protein; Region: DUF3702; pfam12486 273123012666 1 probable transmembrane helix predicted by TMHMM2.0 273123012667 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 273123012668 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 273123012669 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 273123012670 3 probable transmembrane helices predicted by TMHMM2.0 273123012671 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 273123012672 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 273123012673 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 273123012674 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 273123012675 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 273123012676 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 273123012677 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 273123012678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123012679 Walker A motif; other site 273123012680 ATP binding site [chemical binding]; other site 273123012681 Walker B motif; other site 273123012682 arginine finger; other site 273123012683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123012684 Walker A motif; other site 273123012685 ATP binding site [chemical binding]; other site 273123012686 Walker B motif; other site 273123012687 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 273123012688 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 273123012689 1 probable transmembrane helix predicted by TMHMM2.0 273123012690 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 273123012691 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 273123012692 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 273123012693 1 probable transmembrane helix predicted by TMHMM2.0 273123012694 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 273123012695 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 273123012696 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 273123012697 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 273123012698 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 273123012699 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 273123012700 Protein of unknown function (DUF877); Region: DUF877; pfam05943 273123012701 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 273123012702 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 273123012703 maltose regulon periplasmic protein; Provisional; Region: PRK10564 273123012704 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 273123012705 trimer interface; other site 273123012706 sugar binding site [chemical binding]; other site 273123012707 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 273123012708 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 273123012709 Walker A/P-loop; other site 273123012710 ATP binding site [chemical binding]; other site 273123012711 Q-loop/lid; other site 273123012712 ABC transporter signature motif; other site 273123012713 Walker B; other site 273123012714 D-loop; other site 273123012715 H-loop/switch region; other site 273123012716 TOBE domain; Region: TOBE_2; pfam08402 273123012717 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 273123012718 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 273123012719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123012720 dimer interface [polypeptide binding]; other site 273123012721 conserved gate region; other site 273123012722 putative PBP binding loops; other site 273123012723 ABC-ATPase subunit interface; other site 273123012724 8 probable transmembrane helices predicted by TMHMM2.0 273123012725 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273123012726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123012727 dimer interface [polypeptide binding]; other site 273123012728 conserved gate region; other site 273123012729 putative PBP binding loops; other site 273123012730 ABC-ATPase subunit interface; other site 273123012731 6 probable transmembrane helices predicted by TMHMM2.0 273123012732 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 273123012733 4 probable transmembrane helices predicted by TMHMM2.0 273123012734 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 273123012735 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 273123012736 active site 273123012737 dimer interface [polypeptide binding]; other site 273123012738 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 273123012739 dimer interface [polypeptide binding]; other site 273123012740 active site 273123012741 aspartate kinase III; Validated; Region: PRK09084 273123012742 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 273123012743 nucleotide binding site [chemical binding]; other site 273123012744 substrate binding site [chemical binding]; other site 273123012745 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 273123012746 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 273123012747 dimer interface [polypeptide binding]; other site 273123012748 similar to Yersinia pestis YPO3720 shlB, hpmB; hemolysin activator protein (100% evalue=8.E-35);pseudogene of hemolysin activator protein 273123012749 haemagglutination activity domain; Region: Haemagg_act; pfam05860 273123012750 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123012751 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123012752 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 273123012753 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123012754 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123012755 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 273123012756 1 probable transmembrane helix predicted by TMHMM2.0 273123012757 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 273123012758 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 273123012759 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 273123012760 substrate binding pocket [chemical binding]; other site 273123012761 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 273123012762 B12 binding site [chemical binding]; other site 273123012763 cobalt ligand [ion binding]; other site 273123012764 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 273123012765 transcriptional repressor IclR; Provisional; Region: PRK11569 273123012766 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 273123012767 Bacterial transcriptional regulator; Region: IclR; pfam01614 273123012768 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 273123012769 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 273123012770 isocitrate lyase; Provisional; Region: PRK15063 273123012771 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 273123012772 tetramer interface [polypeptide binding]; other site 273123012773 active site 273123012774 Mg2+/Mn2+ binding site [ion binding]; other site 273123012775 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 273123012776 malate synthase A; Region: malate_syn_A; TIGR01344 273123012777 active site 273123012778 homoserine O-succinyltransferase; Provisional; Region: PRK05368 273123012779 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 273123012780 proposed active site lysine [active] 273123012781 conserved cys residue [active] 273123012782 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 273123012783 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 273123012784 trimer interface [polypeptide binding]; other site 273123012785 putative metal binding site [ion binding]; other site 273123012786 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 273123012787 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 273123012788 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 273123012789 shikimate binding site; other site 273123012790 NAD(P) binding site [chemical binding]; other site 273123012791 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 273123012792 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 273123012793 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 273123012794 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 273123012795 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 273123012796 hypothetical protein; Validated; Region: PRK03430 273123012797 hypothetical protein; Provisional; Region: PRK10736 273123012798 DNA protecting protein DprA; Region: dprA; TIGR00732 273123012799 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 273123012800 active site 273123012801 catalytic residues [active] 273123012802 metal binding site [ion binding]; metal-binding site 273123012803 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 273123012804 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 273123012805 putative active site [active] 273123012806 substrate binding site [chemical binding]; other site 273123012807 putative cosubstrate binding site; other site 273123012808 catalytic site [active] 273123012809 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 273123012810 substrate binding site [chemical binding]; other site 273123012811 16S rRNA methyltransferase B; Provisional; Region: PRK10901 273123012812 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 273123012813 putative RNA binding site [nucleotide binding]; other site 273123012814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123012815 S-adenosylmethionine binding site [chemical binding]; other site 273123012816 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 273123012817 TrkA-N domain; Region: TrkA_N; pfam02254 273123012818 TrkA-C domain; Region: TrkA_C; pfam02080 273123012819 TrkA-N domain; Region: TrkA_N; pfam02254 273123012820 TrkA-C domain; Region: TrkA_C; pfam02080 273123012821 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 273123012822 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 273123012823 2 probable transmembrane helices predicted by TMHMM2.0 273123012824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 273123012825 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 273123012826 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 273123012827 DNA binding residues [nucleotide binding] 273123012828 dimer interface [polypeptide binding]; other site 273123012829 metal binding site [ion binding]; metal-binding site 273123012830 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 273123012831 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 273123012832 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 273123012833 alphaNTD homodimer interface [polypeptide binding]; other site 273123012834 alphaNTD - beta interaction site [polypeptide binding]; other site 273123012835 alphaNTD - beta' interaction site [polypeptide binding]; other site 273123012836 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 273123012837 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 273123012838 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 273123012839 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273123012840 RNA binding surface [nucleotide binding]; other site 273123012841 30S ribosomal protein S11; Validated; Region: PRK05309 273123012842 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 273123012843 30S ribosomal protein S13; Region: bact_S13; TIGR03631 273123012844 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 273123012845 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 273123012846 SecY translocase; Region: SecY; pfam00344 273123012847 10 probable transmembrane helices predicted by TMHMM2.0 273123012848 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 273123012849 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 273123012850 23S rRNA binding site [nucleotide binding]; other site 273123012851 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 273123012852 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 273123012853 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 273123012854 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 273123012855 5S rRNA interface [nucleotide binding]; other site 273123012856 23S rRNA interface [nucleotide binding]; other site 273123012857 L5 interface [polypeptide binding]; other site 273123012858 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 273123012859 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 273123012860 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 273123012861 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 273123012862 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 273123012863 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 273123012864 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 273123012865 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 273123012866 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 273123012867 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 273123012868 RNA binding site [nucleotide binding]; other site 273123012869 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 273123012870 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 273123012871 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 273123012872 23S rRNA interface [nucleotide binding]; other site 273123012873 putative translocon interaction site; other site 273123012874 signal recognition particle (SRP54) interaction site; other site 273123012875 L23 interface [polypeptide binding]; other site 273123012876 trigger factor interaction site; other site 273123012877 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 273123012878 23S rRNA interface [nucleotide binding]; other site 273123012879 5S rRNA interface [nucleotide binding]; other site 273123012880 putative antibiotic binding site [chemical binding]; other site 273123012881 L25 interface [polypeptide binding]; other site 273123012882 L27 interface [polypeptide binding]; other site 273123012883 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 273123012884 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 273123012885 G-X-X-G motif; other site 273123012886 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 273123012887 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 273123012888 protein-rRNA interface [nucleotide binding]; other site 273123012889 putative translocon binding site; other site 273123012890 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 273123012891 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 273123012892 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 273123012893 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 273123012894 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 273123012895 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 273123012896 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 273123012897 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 273123012898 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 273123012899 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 273123012900 heme binding site [chemical binding]; other site 273123012901 ferroxidase pore; other site 273123012902 ferroxidase diiron center [ion binding]; other site 273123012903 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 273123012904 elongation factor Tu; Reviewed; Region: PRK00049 273123012905 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 273123012906 G1 box; other site 273123012907 GEF interaction site [polypeptide binding]; other site 273123012908 GTP/Mg2+ binding site [chemical binding]; other site 273123012909 Switch I region; other site 273123012910 G2 box; other site 273123012911 G3 box; other site 273123012912 Switch II region; other site 273123012913 G4 box; other site 273123012914 G5 box; other site 273123012915 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 273123012916 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 273123012917 Antibiotic Binding Site [chemical binding]; other site 273123012918 elongation factor G; Reviewed; Region: PRK00007 273123012919 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 273123012920 G1 box; other site 273123012921 putative GEF interaction site [polypeptide binding]; other site 273123012922 GTP/Mg2+ binding site [chemical binding]; other site 273123012923 Switch I region; other site 273123012924 G2 box; other site 273123012925 G3 box; other site 273123012926 Switch II region; other site 273123012927 G4 box; other site 273123012928 G5 box; other site 273123012929 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 273123012930 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 273123012931 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 273123012932 30S ribosomal protein S7; Validated; Region: PRK05302 273123012933 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 273123012934 S17 interaction site [polypeptide binding]; other site 273123012935 S8 interaction site; other site 273123012936 16S rRNA interaction site [nucleotide binding]; other site 273123012937 streptomycin interaction site [chemical binding]; other site 273123012938 23S rRNA interaction site [nucleotide binding]; other site 273123012939 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 273123012940 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 273123012941 sulfur relay protein TusC; Validated; Region: PRK00211 273123012942 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 273123012943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 273123012944 YheO-like PAS domain; Region: PAS_6; pfam08348 273123012945 HTH domain; Region: HTH_22; pfam13309 273123012946 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 273123012947 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 273123012948 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 273123012949 phi X174 lysis protein; Provisional; Region: PRK02793 273123012950 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 273123012951 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 273123012952 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 273123012953 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 273123012954 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 273123012955 TrkA-N domain; Region: TrkA_N; pfam02254 273123012956 12 probable transmembrane helices predicted by TMHMM2.0 273123012957 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 273123012958 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 273123012959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123012960 Walker A/P-loop; other site 273123012961 ATP binding site [chemical binding]; other site 273123012962 Q-loop/lid; other site 273123012963 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273123012964 ABC transporter signature motif; other site 273123012965 Walker B; other site 273123012966 D-loop; other site 273123012967 ABC transporter; Region: ABC_tran_2; pfam12848 273123012968 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 273123012969 putative glycosyl transferase; Provisional; Region: PRK10073 273123012970 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 273123012971 active site 273123012972 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 273123012973 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 273123012974 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 273123012975 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 273123012976 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 273123012977 active site 273123012978 iron coordination sites [ion binding]; other site 273123012979 substrate binding pocket [chemical binding]; other site 273123012980 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 273123012981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123012982 dimer interface [polypeptide binding]; other site 273123012983 conserved gate region; other site 273123012984 putative PBP binding loops; other site 273123012985 ABC-ATPase subunit interface; other site 273123012986 6 probable transmembrane helices predicted by TMHMM2.0 273123012987 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 273123012988 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 273123012989 Walker A/P-loop; other site 273123012990 ATP binding site [chemical binding]; other site 273123012991 Q-loop/lid; other site 273123012992 ABC transporter signature motif; other site 273123012993 Walker B; other site 273123012994 D-loop; other site 273123012995 H-loop/switch region; other site 273123012996 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 273123012997 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123012998 substrate binding pocket [chemical binding]; other site 273123012999 membrane-bound complex binding site; other site 273123013000 hinge residues; other site 273123013001 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 273123013002 6 probable transmembrane helices predicted by TMHMM2.0 273123013003 putative hydrolase; Provisional; Region: PRK10985 273123013004 hypothetical protein; Provisional; Region: PRK04966 273123013005 phosphoribulokinase; Provisional; Region: PRK15453 273123013006 active site 273123013007 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 273123013008 3 probable transmembrane helices predicted by TMHMM2.0 273123013009 hypothetical protein; Provisional; Region: PRK10738 273123013010 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 273123013011 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 273123013012 ligand binding site [chemical binding]; other site 273123013013 flexible hinge region; other site 273123013014 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 273123013015 putative switch regulator; other site 273123013016 non-specific DNA interactions [nucleotide binding]; other site 273123013017 DNA binding site [nucleotide binding] 273123013018 sequence specific DNA binding site [nucleotide binding]; other site 273123013019 putative cAMP binding site [chemical binding]; other site 273123013020 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 273123013021 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 273123013022 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 273123013023 8 probable transmembrane helices predicted by TMHMM2.0 273123013024 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 273123013025 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 273123013026 inhibitor-cofactor binding pocket; inhibition site 273123013027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123013028 catalytic residue [active] 273123013029 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 273123013030 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 273123013031 glutamine binding [chemical binding]; other site 273123013032 catalytic triad [active] 273123013033 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 273123013034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 273123013035 Walker A motif; other site 273123013036 ATP binding site [chemical binding]; other site 273123013037 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 273123013038 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 273123013039 substrate binding site [chemical binding]; other site 273123013040 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 273123013041 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 273123013042 NAD binding site [chemical binding]; other site 273123013043 sugar binding site [chemical binding]; other site 273123013044 divalent metal binding site [ion binding]; other site 273123013045 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273123013046 dimer interface [polypeptide binding]; other site 273123013047 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273123013048 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123013049 DNA binding site [nucleotide binding] 273123013050 domain linker motif; other site 273123013051 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 273123013052 dimerization interface (closed form) [polypeptide binding]; other site 273123013053 ligand binding site [chemical binding]; other site 273123013054 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 273123013055 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 273123013056 N-terminal plug; other site 273123013057 ligand-binding site [chemical binding]; other site 273123013058 1 probable transmembrane helix predicted by TMHMM2.0 273123013059 putative transporter; Provisional; Region: PRK03699 273123013060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123013061 putative substrate translocation pore; other site 273123013062 12 probable transmembrane helices predicted by TMHMM2.0 273123013063 cytosine deaminase; Provisional; Region: PRK09230 273123013064 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 273123013065 active site 273123013066 nitrite reductase subunit NirD; Provisional; Region: PRK14989 273123013067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273123013068 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 273123013069 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 273123013070 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 273123013071 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 273123013072 nitrite transporter NirC; Provisional; Region: PRK11562 273123013073 6 probable transmembrane helices predicted by TMHMM2.0 273123013074 siroheme synthase; Provisional; Region: cysG; PRK10637 273123013075 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 273123013076 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 273123013077 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 273123013078 active site 273123013079 SAM binding site [chemical binding]; other site 273123013080 homodimer interface [polypeptide binding]; other site 273123013081 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 273123013082 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 273123013083 active site 273123013084 HIGH motif; other site 273123013085 dimer interface [polypeptide binding]; other site 273123013086 KMSKS motif; other site 273123013087 phosphoglycolate phosphatase; Provisional; Region: PRK13222 273123013088 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 273123013089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123013090 motif II; other site 273123013091 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 273123013092 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 273123013093 substrate binding site [chemical binding]; other site 273123013094 hexamer interface [polypeptide binding]; other site 273123013095 metal binding site [ion binding]; metal-binding site 273123013096 DNA adenine methylase; Provisional; Region: PRK10904 273123013097 hypothetical protein; Reviewed; Region: PRK11901 273123013098 cell division protein DamX; Validated; Region: PRK10905 273123013099 1 probable transmembrane helix predicted by TMHMM2.0 273123013100 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 273123013101 active site 273123013102 dimer interface [polypeptide binding]; other site 273123013103 metal binding site [ion binding]; metal-binding site 273123013104 shikimate kinase; Reviewed; Region: aroK; PRK00131 273123013105 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 273123013106 ADP binding site [chemical binding]; other site 273123013107 magnesium binding site [ion binding]; other site 273123013108 putative shikimate binding site; other site 273123013109 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 273123013110 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 273123013111 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 273123013112 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 273123013113 1 probable transmembrane helix predicted by TMHMM2.0 273123013114 1 probable transmembrane helix predicted by TMHMM2.0 273123013115 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 273123013116 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 273123013117 1 probable transmembrane helix predicted by TMHMM2.0 273123013118 Competence protein A; Region: Competence_A; pfam11104 273123013119 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 273123013120 Transglycosylase; Region: Transgly; pfam00912 273123013121 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 273123013122 1 probable transmembrane helix predicted by TMHMM2.0 273123013123 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 273123013124 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 273123013125 ADP-ribose binding site [chemical binding]; other site 273123013126 dimer interface [polypeptide binding]; other site 273123013127 active site 273123013128 nudix motif; other site 273123013129 metal binding site [ion binding]; metal-binding site 273123013131 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 273123013132 5 probable transmembrane helices predicted by TMHMM2.0 273123013133 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 273123013134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 273123013135 motif I; other site 273123013136 active site 273123013137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123013138 motif II; other site 273123013139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273123013140 RNA binding surface [nucleotide binding]; other site 273123013141 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 273123013142 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 273123013143 dimerization interface [polypeptide binding]; other site 273123013144 domain crossover interface; other site 273123013145 redox-dependent activation switch; other site 273123013146 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 273123013147 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 273123013148 active site 273123013149 substrate-binding site [chemical binding]; other site 273123013150 metal-binding site [ion binding] 273123013151 ATP binding site [chemical binding]; other site 273123013152 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 273123013153 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123013154 dimerization interface [polypeptide binding]; other site 273123013155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123013156 dimer interface [polypeptide binding]; other site 273123013157 phosphorylation site [posttranslational modification] 273123013158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123013159 ATP binding site [chemical binding]; other site 273123013160 Mg2+ binding site [ion binding]; other site 273123013161 G-X-G motif; other site 273123013162 2 probable transmembrane helices predicted by TMHMM2.0 273123013163 osmolarity response regulator; Provisional; Region: ompR; PRK09468 273123013164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123013165 active site 273123013166 phosphorylation site [posttranslational modification] 273123013167 intermolecular recognition site; other site 273123013168 dimerization interface [polypeptide binding]; other site 273123013169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123013170 DNA binding site [nucleotide binding] 273123013171 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 273123013172 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 273123013173 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 273123013174 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 273123013175 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 273123013176 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 273123013177 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 273123013178 RNA binding site [nucleotide binding]; other site 273123013179 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 273123013180 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 273123013181 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 273123013182 G1 box; other site 273123013183 GTP/Mg2+ binding site [chemical binding]; other site 273123013184 Switch I region; other site 273123013185 G2 box; other site 273123013186 G3 box; other site 273123013187 Switch II region; other site 273123013188 G4 box; other site 273123013189 G5 box; other site 273123013190 Nucleoside recognition; Region: Gate; pfam07670 273123013191 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 273123013192 Nucleoside recognition; Region: Gate; pfam07670 273123013193 9 probable transmembrane helices predicted by TMHMM2.0 273123013194 FeoC like transcriptional regulator; Region: FeoC; cl17677 273123013195 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 273123013196 carboxylesterase BioH; Provisional; Region: PRK10349 273123013197 DNA utilization protein GntX; Provisional; Region: PRK11595 273123013198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273123013199 active site 273123013200 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 273123013201 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 273123013202 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 273123013203 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 273123013204 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 273123013205 maltodextrin phosphorylase; Provisional; Region: PRK14985 273123013206 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 273123013207 active site pocket [active] 273123013208 transcriptional regulator MalT; Provisional; Region: PRK04841 273123013209 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123013210 DNA binding residues [nucleotide binding] 273123013211 dimerization interface [polypeptide binding]; other site 273123013212 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 273123013213 active site residue [active] 273123013214 intramembrane serine protease GlpG; Provisional; Region: PRK10907 273123013215 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 273123013216 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 273123013217 6 probable transmembrane helices predicted by TMHMM2.0 273123013218 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 273123013219 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 273123013220 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 273123013221 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 273123013222 1 probable transmembrane helix predicted by TMHMM2.0 273123013223 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 273123013224 glycogen phosphorylase; Provisional; Region: PRK14986 273123013225 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 273123013226 homodimer interface [polypeptide binding]; other site 273123013227 active site pocket [active] 273123013228 glycogen synthase; Provisional; Region: glgA; PRK00654 273123013229 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 273123013230 ADP-binding pocket [chemical binding]; other site 273123013231 homodimer interface [polypeptide binding]; other site 273123013232 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 273123013233 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 273123013234 ligand binding site; other site 273123013235 oligomer interface; other site 273123013236 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 273123013237 sulfate 1 binding site; other site 273123013238 glycogen debranching enzyme; Provisional; Region: PRK03705 273123013239 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 273123013240 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 273123013241 active site 273123013242 catalytic site [active] 273123013243 glycogen branching enzyme; Provisional; Region: PRK05402 273123013244 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 273123013245 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 273123013246 active site 273123013247 catalytic site [active] 273123013248 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 273123013249 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 273123013250 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 273123013251 Histidine kinase; Region: His_kinase; pfam06580 273123013252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123013253 ATP binding site [chemical binding]; other site 273123013254 Mg2+ binding site [ion binding]; other site 273123013255 G-X-G motif; other site 273123013256 6 probable transmembrane helices predicted by TMHMM2.0 273123013257 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 273123013258 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 273123013259 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 273123013260 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013261 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013262 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013263 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013264 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013265 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013266 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013267 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013268 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013269 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013270 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013271 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013272 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013273 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013274 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013275 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 273123013276 1 probable transmembrane helix predicted by TMHMM2.0 273123013277 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 273123013278 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 273123013279 putative antibiotic transporter; Provisional; Region: PRK10739 273123013280 6 probable transmembrane helices predicted by TMHMM2.0 273123013281 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 273123013282 AAA domain; Region: AAA_33; pfam13671 273123013283 ATP-binding site [chemical binding]; other site 273123013284 Gluconate-6-phosphate binding site [chemical binding]; other site 273123013285 high-affinity gluconate transporter; Provisional; Region: PRK14984 273123013286 gluconate transporter; Region: gntP; TIGR00791 273123013287 11 probable transmembrane helices predicted by TMHMM2.0 273123013288 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 273123013289 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273123013290 DNA binding site [nucleotide binding] 273123013291 domain linker motif; other site 273123013292 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 273123013293 putative ligand binding site [chemical binding]; other site 273123013294 putative dimerization interface [polypeptide binding]; other site 273123013295 Pirin-related protein [General function prediction only]; Region: COG1741 273123013296 Pirin; Region: Pirin; pfam02678 273123013297 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273123013298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123013299 active site 273123013300 phosphorylation site [posttranslational modification] 273123013301 intermolecular recognition site; other site 273123013302 dimerization interface [polypeptide binding]; other site 273123013303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273123013304 DNA binding site [nucleotide binding] 273123013305 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 273123013306 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 273123013307 substrate binding site [chemical binding]; other site 273123013308 ATP binding site [chemical binding]; other site 273123013309 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 273123013310 intersubunit interface [polypeptide binding]; other site 273123013311 active site 273123013312 zinc binding site [ion binding]; other site 273123013313 Na+ binding site [ion binding]; other site 273123013314 ABC-type sugar transport system, auxiliary component [General function prediction only]; Region: COG3822 273123013315 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 273123013316 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 273123013317 putative ligand binding site [chemical binding]; other site 273123013318 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123013319 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123013320 TM-ABC transporter signature motif; other site 273123013321 8 probable transmembrane helices predicted by TMHMM2.0 273123013322 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273123013323 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123013324 Walker A/P-loop; other site 273123013325 ATP binding site [chemical binding]; other site 273123013326 Q-loop/lid; other site 273123013327 ABC transporter signature motif; other site 273123013328 Walker B; other site 273123013329 D-loop; other site 273123013330 H-loop/switch region; other site 273123013331 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123013332 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 273123013333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123013334 dimerization interface [polypeptide binding]; other site 273123013335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273123013336 dimer interface [polypeptide binding]; other site 273123013337 phosphorylation site [posttranslational modification] 273123013338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123013339 ATP binding site [chemical binding]; other site 273123013340 Mg2+ binding site [ion binding]; other site 273123013341 G-X-G motif; other site 273123013342 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 273123013343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123013344 active site 273123013345 phosphorylation site [posttranslational modification] 273123013346 intermolecular recognition site; other site 273123013347 dimerization interface [polypeptide binding]; other site 273123013348 2 probable transmembrane helices predicted by TMHMM2.0 273123013349 Predicted flavoproteins [General function prediction only]; Region: COG2081 273123013350 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 273123013351 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 273123013352 10 probable transmembrane helices predicted by TMHMM2.0 273123013353 universal stress protein UspB; Provisional; Region: PRK04960 273123013354 2 probable transmembrane helices predicted by TMHMM2.0 273123013355 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 273123013356 Ligand Binding Site [chemical binding]; other site 273123013357 glutamate dehydrogenase; Provisional; Region: PRK09414 273123013358 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 273123013359 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 273123013360 NAD(P) binding site [chemical binding]; other site 273123013361 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 273123013362 active site 273123013363 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 273123013364 putative methyltransferase; Provisional; Region: PRK10742 273123013365 oligopeptidase A; Provisional; Region: PRK10911 273123013366 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 273123013367 active site 273123013368 Zn binding site [ion binding]; other site 273123013369 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 273123013370 glutathione reductase; Validated; Region: PRK06116 273123013371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 273123013372 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273123013373 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273123013374 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 273123013375 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 273123013376 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 273123013377 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 273123013378 fructuronate transporter; Provisional; Region: PRK10034; cl15264 273123013379 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 273123013380 11 probable transmembrane helices predicted by TMHMM2.0 273123013381 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 273123013382 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 273123013383 conserved hypothetical protein; Region: TIGR03034 273123013384 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 273123013385 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 273123013386 Autotransporter beta-domain; Region: Autotransporter; smart00869 273123013387 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 273123013388 6 probable transmembrane helices predicted by TMHMM2.0 273123013389 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 273123013390 1 probable transmembrane helix predicted by TMHMM2.0 273123013391 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 273123013392 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 273123013393 1 probable transmembrane helix predicted by TMHMM2.0 273123013394 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 273123013395 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 273123013396 active site 1 [active] 273123013397 dimer interface [polypeptide binding]; other site 273123013398 hexamer interface [polypeptide binding]; other site 273123013399 active site 2 [active] 273123013400 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 273123013401 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 273123013402 substrate binding site [chemical binding]; other site 273123013403 ATP binding site [chemical binding]; other site 273123013404 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 273123013405 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 273123013406 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 273123013407 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 273123013408 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 273123013409 8 probable transmembrane helices predicted by TMHMM2.0 273123013410 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 273123013411 sugar binding site [chemical binding]; other site 273123013412 1 probable transmembrane helix predicted by TMHMM2.0 273123013413 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 273123013414 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 273123013415 biofilm formation regulator HmsP; Provisional; Region: PRK11829 273123013416 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 273123013417 metal binding site [ion binding]; metal-binding site 273123013418 active site 273123013419 I-site; other site 273123013420 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 273123013421 2 probable transmembrane helices predicted by TMHMM2.0 273123013422 endo-1,4-D-glucanase; Provisional; Region: PRK11097 273123013423 1 probable transmembrane helix predicted by TMHMM2.0 273123013424 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 273123013425 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123013426 Walker A/P-loop; other site 273123013427 ATP binding site [chemical binding]; other site 273123013428 Q-loop/lid; other site 273123013429 ABC transporter signature motif; other site 273123013430 Walker B; other site 273123013431 D-loop; other site 273123013432 H-loop/switch region; other site 273123013433 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 273123013434 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 273123013435 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 273123013436 Walker A/P-loop; other site 273123013437 ATP binding site [chemical binding]; other site 273123013438 Q-loop/lid; other site 273123013439 ABC transporter signature motif; other site 273123013440 Walker B; other site 273123013441 D-loop; other site 273123013442 H-loop/switch region; other site 273123013443 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 273123013444 dipeptide transporter; Provisional; Region: PRK10913 273123013445 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 273123013446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123013447 dimer interface [polypeptide binding]; other site 273123013448 conserved gate region; other site 273123013449 putative PBP binding loops; other site 273123013450 ABC-ATPase subunit interface; other site 273123013451 5 probable transmembrane helices predicted by TMHMM2.0 273123013452 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273123013453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123013454 dimer interface [polypeptide binding]; other site 273123013455 conserved gate region; other site 273123013456 putative PBP binding loops; other site 273123013457 ABC-ATPase subunit interface; other site 273123013458 6 probable transmembrane helices predicted by TMHMM2.0 273123013459 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 273123013460 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 273123013461 peptide binding site [polypeptide binding]; other site 273123013462 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 273123013463 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 273123013464 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 273123013465 1 probable transmembrane helix predicted by TMHMM2.0 273123013466 haemagglutination activity domain; Region: Haemagg_act; pfam05860 273123013467 regulatory protein UhpC; Provisional; Region: PRK11663 273123013468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123013469 putative substrate translocation pore; other site 273123013470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123013471 10 probable transmembrane helices predicted by TMHMM2.0 273123013472 sensory histidine kinase UhpB; Provisional; Region: PRK11644 273123013473 MASE1; Region: MASE1; pfam05231 273123013474 Histidine kinase; Region: HisKA_3; pfam07730 273123013475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123013476 ATP binding site [chemical binding]; other site 273123013477 Mg2+ binding site [ion binding]; other site 273123013478 G-X-G motif; other site 273123013479 7 probable transmembrane helices predicted by TMHMM2.0 273123013480 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 273123013481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273123013482 active site 273123013483 phosphorylation site [posttranslational modification] 273123013484 intermolecular recognition site; other site 273123013485 dimerization interface [polypeptide binding]; other site 273123013486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273123013487 DNA binding residues [nucleotide binding] 273123013488 dimerization interface [polypeptide binding]; other site 273123013489 phosphoethanolamine transferase; Provisional; Region: PRK11560 273123013490 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 273123013491 Sulfatase; Region: Sulfatase; pfam00884 273123013492 5 probable transmembrane helices predicted by TMHMM2.0 273123013493 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 273123013494 1 probable transmembrane helix predicted by TMHMM2.0 273123013495 putative proline-specific permease; Provisional; Region: proY; PRK10580 273123013496 12 probable transmembrane helices predicted by TMHMM2.0 273123013497 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 273123013498 active sites [active] 273123013499 tetramer interface [polypeptide binding]; other site 273123013500 urocanate hydratase; Provisional; Region: PRK05414 273123013501 similar to Yersinia pestis YPO4018 cysM; pyridoxal-phosphate dependent protein (100% evalue=1.E-55); Escherichia coli ECs3292 cysteine synthase B (42.4% evalue=4.E-16);pseudogene of pyridoxal-phosphate dependent protein 273123013502 similar to Yersinia pestis YPO4019 phosphoribosyl transferase (100% evalue=3.E-97); Methanocaldococcus jannaschii MJ1655 apt; adenine phosphoribosyltransferase (APRT) (40.1% evalue=4.E-27);pseudogene phosphoribosyl transferase 273123013503 10 probable transmembrane helices predicted by TMHMM2.0 273123013504 hypothetical protein; Provisional; Region: PRK07206 273123013505 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 273123013506 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 273123013507 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 273123013508 putative ligand binding residues [chemical binding]; other site 273123013509 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 273123013510 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123013511 ABC-ATPase subunit interface; other site 273123013512 dimer interface [polypeptide binding]; other site 273123013513 putative PBP binding regions; other site 273123013514 9 probable transmembrane helices predicted by TMHMM2.0 273123013515 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273123013516 ABC-ATPase subunit interface; other site 273123013517 dimer interface [polypeptide binding]; other site 273123013518 putative PBP binding regions; other site 273123013519 9 probable transmembrane helices predicted by TMHMM2.0 273123013520 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 273123013521 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 273123013522 Walker A/P-loop; other site 273123013523 ATP binding site [chemical binding]; other site 273123013524 Q-loop/lid; other site 273123013525 ABC transporter signature motif; other site 273123013526 Walker B; other site 273123013527 D-loop; other site 273123013528 H-loop/switch region; other site 273123013529 similar to Yersinia pestis YPO4026 conserved hypothetical protein (partial) (100% evalue=9.E-91); Salmonella typhimurium STM3755 rhuM; cytoplasmic protein (82% evalue=3.E-72);conserved hypothetical protein (partial) 273123013530 Virulence protein [General function prediction only]; Region: COG3943 273123013531 Predicted transcriptional regulator [Transcription]; Region: COG3888 273123013532 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 273123013533 Methyltransferase domain; Region: Methyltransf_27; pfam13708 273123013534 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 273123013535 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 273123013536 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 273123013537 MPN+ (JAMM) motif; other site 273123013538 Zinc-binding site [ion binding]; other site 273123013539 2 probable transmembrane helices predicted by TMHMM2.0 273123013540 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 273123013541 G3 box; other site 273123013542 Switch II region; other site 273123013543 Predicted GTPase [General function prediction only]; Region: COG3596 273123013544 G4 box; other site 273123013545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 273123013546 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 273123013547 similar to Escherichia coli b4351 mrr; mrr restriction system protein (90.7% evalue=1.E-102); Escherichia coli JW4314 mrr; Mrr protein. (90.7% evalue=1.E-102);mrr restriction system protein, pseudogene, interrupted by IS100 273123013549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 273123013550 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 273123013551 DNA-binding interface [nucleotide binding]; DNA binding site 273123013552 Integrase core domain; Region: rve; pfam00665 273123013553 transposase/IS protein; Provisional; Region: PRK09183 273123013554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123013555 Walker A motif; other site 273123013556 ATP binding site [chemical binding]; other site 273123013557 Walker B motif; other site 273123013558 similar to Escherichia coli b4351 mrr; mrr restriction system protein (78.6% evalue=1.E-43); Escherichia coli JW4314 mrr; Mrr protein. (78.6% evalue=1.E-43);mrr restriction system protein, pseudogene, interrupted by IS100 273123013559 Protein of unknown function DUF45; Region: DUF45; pfam01863 273123013560 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 273123013561 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 273123013562 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273123013563 ATP binding site [chemical binding]; other site 273123013564 putative Mg++ binding site [ion binding]; other site 273123013565 Virulence protein [General function prediction only]; Region: COG3943 273123013566 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 273123013567 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 273123013568 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 273123013569 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 273123013570 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 273123013571 HsdM N-terminal domain; Region: HsdM_N; pfam12161 273123013572 Methyltransferase domain; Region: Methyltransf_26; pfam13659 273123013573 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 273123013574 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 273123013575 integrase; Provisional; Region: PRK09692 273123013576 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 273123013577 active site 273123013578 Int/Topo IB signature motif; other site 273123013579 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 273123013580 putative dimerization interface [polypeptide binding]; other site 273123013581 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273123013582 putative ligand binding site [chemical binding]; other site 273123013583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123013584 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 273123013585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273123013586 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 273123013587 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 273123013588 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273123013589 TM-ABC transporter signature motif; other site 273123013590 10 probable transmembrane helices predicted by TMHMM2.0 273123013591 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 273123013592 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 273123013593 Walker A/P-loop; other site 273123013594 ATP binding site [chemical binding]; other site 273123013595 Q-loop/lid; other site 273123013596 ABC transporter signature motif; other site 273123013597 Walker B; other site 273123013598 D-loop; other site 273123013599 H-loop/switch region; other site 273123013600 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 273123013601 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 273123013602 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 273123013603 putative ligand binding site [chemical binding]; other site 273123013604 xylose isomerase; Provisional; Region: PRK05474 273123013605 xylose isomerase; Region: xylose_isom_A; TIGR02630 273123013606 xylulokinase; Provisional; Region: PRK15027 273123013607 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 273123013608 N- and C-terminal domain interface [polypeptide binding]; other site 273123013609 active site 273123013610 MgATP binding site [chemical binding]; other site 273123013611 catalytic site [active] 273123013612 metal binding site [ion binding]; metal-binding site 273123013613 xylulose binding site [chemical binding]; other site 273123013614 homodimer interface [polypeptide binding]; other site 273123013615 Fimbrial protein; Region: Fimbrial; pfam00419 273123013616 1 probable transmembrane helix predicted by TMHMM2.0 273123013617 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 273123013618 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 273123013619 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 273123013620 1 probable transmembrane helix predicted by TMHMM2.0 273123013621 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 273123013622 PapC N-terminal domain; Region: PapC_N; pfam13954 273123013623 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 273123013624 PapC C-terminal domain; Region: PapC_C; pfam13953 273123013625 1 probable transmembrane helix predicted by TMHMM2.0 273123013626 Fimbrial protein; Region: Fimbrial; cl01416 273123013627 1 probable transmembrane helix predicted by TMHMM2.0 273123013628 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 273123013629 Acyltransferase family; Region: Acyl_transf_3; pfam01757 273123013630 10 probable transmembrane helices predicted by TMHMM2.0 273123013631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 273123013632 Helix-turn-helix domain; Region: HTH_28; pfam13518 273123013633 Helix-turn-helix domain; Region: HTH_28; pfam13518 273123013634 putative transposase OrfB; Reviewed; Region: PHA02517 273123013635 HTH-like domain; Region: HTH_21; pfam13276 273123013636 Integrase core domain; Region: rve; pfam00665 273123013637 Integrase core domain; Region: rve_2; pfam13333 273123013638 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 273123013639 ornithine cyclodeaminase; Validated; Region: PRK06823 273123013640 hypothetical protein; Provisional; Region: PRK06815 273123013641 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 273123013642 tetramer interface [polypeptide binding]; other site 273123013643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123013644 catalytic residue [active] 273123013645 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 273123013646 hypothetical protein; Provisional; Region: PRK11616 273123013647 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 273123013648 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 273123013649 putative dimer interface [polypeptide binding]; other site 273123013650 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 273123013651 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 273123013652 putative dimer interface [polypeptide binding]; other site 273123013653 putative transporter; Validated; Region: PRK03818 273123013654 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 273123013655 TrkA-C domain; Region: TrkA_C; pfam02080 273123013656 TrkA-C domain; Region: TrkA_C; pfam02080 273123013657 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 273123013658 11 probable transmembrane helices predicted by TMHMM2.0 273123013659 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 273123013660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273123013661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273123013662 homodimer interface [polypeptide binding]; other site 273123013663 catalytic residue [active] 273123013664 4 probable transmembrane helices predicted by TMHMM2.0 273123013665 alpha-amylase; Reviewed; Region: malS; PRK09505 273123013666 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 273123013667 active site 273123013668 catalytic site [active] 273123013669 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 273123013670 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 273123013671 dimerization interface [polypeptide binding]; other site 273123013672 ligand binding site [chemical binding]; other site 273123013673 NADP binding site [chemical binding]; other site 273123013674 catalytic site [active] 273123013675 Predicted transcriptional regulator [Transcription]; Region: COG2345 273123013676 putative outer membrane lipoprotein; Provisional; Region: PRK10510 273123013677 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 273123013678 ligand binding site [chemical binding]; other site 273123013679 3 probable transmembrane helices predicted by TMHMM2.0 273123013680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 273123013681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273123013682 Coenzyme A binding pocket [chemical binding]; other site 273123013683 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 273123013684 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 273123013685 dimer interface [polypeptide binding]; other site 273123013686 motif 1; other site 273123013687 active site 273123013688 motif 2; other site 273123013689 motif 3; other site 273123013690 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 273123013691 DALR anticodon binding domain; Region: DALR_1; pfam05746 273123013692 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 273123013693 1 probable transmembrane helix predicted by TMHMM2.0 273123013694 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 273123013695 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 273123013696 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 273123013697 active site 273123013698 P-loop; other site 273123013699 phosphorylation site [posttranslational modification] 273123013700 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273123013701 active site 273123013702 phosphorylation site [posttranslational modification] 273123013703 9 probable transmembrane helices predicted by TMHMM2.0 273123013704 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 273123013705 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 273123013706 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 273123013707 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 273123013708 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 273123013709 hypothetical protein; Provisional; Region: PRK11020 273123013710 Electron transfer DM13; Region: DM13; pfam10517 273123013711 1 probable transmembrane helix predicted by TMHMM2.0 273123013712 1 probable transmembrane helix predicted by TMHMM2.0 273123013713 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273123013714 dimerization interface [polypeptide binding]; other site 273123013715 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 273123013716 dimer interface [polypeptide binding]; other site 273123013717 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 273123013718 putative CheW interface [polypeptide binding]; other site 273123013719 1 probable transmembrane helix predicted by TMHMM2.0 273123013720 superoxide dismutase; Provisional; Region: PRK10925 273123013721 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 273123013722 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 273123013723 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 273123013724 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 273123013725 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 273123013726 [4Fe-4S] binding site [ion binding]; other site 273123013727 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 273123013728 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 273123013729 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 273123013730 molybdopterin cofactor binding site; other site 273123013731 1 probable transmembrane helix predicted by TMHMM2.0 273123013732 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 273123013733 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 273123013734 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 273123013735 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 273123013736 4 probable transmembrane helices predicted by TMHMM2.0 273123013737 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 273123013738 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 273123013739 selenocysteine synthase; Provisional; Region: PRK04311 273123013740 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 273123013741 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 273123013742 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273123013743 catalytic residue [active] 273123013744 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 273123013745 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 273123013746 G1 box; other site 273123013747 putative GEF interaction site [polypeptide binding]; other site 273123013748 GTP/Mg2+ binding site [chemical binding]; other site 273123013749 Switch I region; other site 273123013750 G2 box; other site 273123013751 G3 box; other site 273123013752 Switch II region; other site 273123013753 G4 box; other site 273123013754 G5 box; other site 273123013755 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 273123013756 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 273123013757 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 273123013758 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 273123013759 similar to Yersinia pestis YPO4051 tnpA; transposase (partial) (99.3% evalue=4.E-86);transposase (partial) 273123013760 2 probable transmembrane helices predicted by TMHMM2.0 273123013761 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 273123013762 2 probable transmembrane helices predicted by TMHMM2.0 273123013763 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 273123013764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273123013765 putative substrate translocation pore; other site 273123013766 12 probable transmembrane helices predicted by TMHMM2.0 273123013767 putative transposase OrfB; Reviewed; Region: PHA02517 273123013768 HTH-like domain; Region: HTH_21; pfam13276 273123013769 Integrase core domain; Region: rve; pfam00665 273123013770 Integrase core domain; Region: rve_2; pfam13333 273123013771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 273123013772 Helix-turn-helix domain; Region: HTH_28; pfam13518 273123013773 Helix-turn-helix domain; Region: HTH_28; pfam13518 273123013774 sugar phosphate phosphatase; Provisional; Region: PRK10513 273123013775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123013776 active site 273123013777 motif I; other site 273123013778 motif II; other site 273123013779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123013780 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 273123013781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273123013782 Mg2+ binding site [ion binding]; other site 273123013783 G-X-G motif; other site 273123013784 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 273123013785 anchoring element; other site 273123013786 dimer interface [polypeptide binding]; other site 273123013787 ATP binding site [chemical binding]; other site 273123013788 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 273123013789 active site 273123013790 putative metal-binding site [ion binding]; other site 273123013791 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 273123013792 recombination protein F; Reviewed; Region: recF; PRK00064 273123013793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123013794 Walker A/P-loop; other site 273123013795 ATP binding site [chemical binding]; other site 273123013796 Q-loop/lid; other site 273123013797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 273123013798 ABC transporter signature motif; other site 273123013799 Walker B; other site 273123013800 D-loop; other site 273123013801 H-loop/switch region; other site 273123013802 DNA polymerase III subunit beta; Validated; Region: PRK05643 273123013803 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 273123013804 putative DNA binding surface [nucleotide binding]; other site 273123013805 dimer interface [polypeptide binding]; other site 273123013806 beta-clamp/clamp loader binding surface; other site 273123013807 beta-clamp/translesion DNA polymerase binding surface; other site 273123013808 DnaA N-terminal domain; Region: DnaA_N; pfam11638 273123013809 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 273123013810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273123013811 Walker A motif; other site 273123013812 ATP binding site [chemical binding]; other site 273123013813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 273123013814 Walker B motif; other site 273123013815 arginine finger; other site 273123013816 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 273123013817 DnaA box-binding interface [nucleotide binding]; other site 273123013818 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 273123013819 ribonuclease P; Reviewed; Region: rnpA; PRK01732 273123013820 hypothetical protein; Validated; Region: PRK00041 273123013821 membrane protein insertase; Provisional; Region: PRK01318 273123013822 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 273123013823 5 probable transmembrane helices predicted by TMHMM2.0 273123013824 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 273123013825 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 273123013826 trmE is a tRNA modification GTPase; Region: trmE; cd04164 273123013827 G1 box; other site 273123013828 GTP/Mg2+ binding site [chemical binding]; other site 273123013829 Switch I region; other site 273123013830 G2 box; other site 273123013831 Switch II region; other site 273123013832 G3 box; other site 273123013833 G4 box; other site 273123013834 G5 box; other site 273123013835 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 273123013836 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 273123013837 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 273123013838 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 273123013839 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 273123013840 2 probable transmembrane helices predicted by TMHMM2.0 273123013841 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 273123013842 13 probable transmembrane helices predicted by TMHMM2.0 273123013843 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 273123013844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273123013845 motif II; other site 273123013846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123013847 dimer interface [polypeptide binding]; other site 273123013848 conserved gate region; other site 273123013849 putative PBP binding loops; other site 273123013850 ABC-ATPase subunit interface; other site 273123013851 4 probable transmembrane helices predicted by TMHMM2.0 273123013852 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 273123013853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123013854 dimer interface [polypeptide binding]; other site 273123013855 conserved gate region; other site 273123013856 putative PBP binding loops; other site 273123013857 ABC-ATPase subunit interface; other site 273123013858 4 probable transmembrane helices predicted by TMHMM2.0 273123013859 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 273123013860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123013861 substrate binding pocket [chemical binding]; other site 273123013862 membrane-bound complex binding site; other site 273123013863 hinge residues; other site 273123013864 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 273123013865 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 273123013866 2 probable transmembrane helices predicted by TMHMM2.0 273123013867 transcriptional regulator PhoU; Provisional; Region: PRK11115 273123013868 PhoU domain; Region: PhoU; pfam01895 273123013869 PhoU domain; Region: PhoU; pfam01895 273123013870 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 273123013871 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 273123013872 Walker A/P-loop; other site 273123013873 ATP binding site [chemical binding]; other site 273123013874 Q-loop/lid; other site 273123013875 ABC transporter signature motif; other site 273123013876 Walker B; other site 273123013877 D-loop; other site 273123013878 H-loop/switch region; other site 273123013879 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 273123013880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123013881 dimer interface [polypeptide binding]; other site 273123013882 conserved gate region; other site 273123013883 putative PBP binding loops; other site 273123013884 ABC-ATPase subunit interface; other site 273123013885 6 probable transmembrane helices predicted by TMHMM2.0 273123013886 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 273123013887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273123013888 dimer interface [polypeptide binding]; other site 273123013889 conserved gate region; other site 273123013890 putative PBP binding loops; other site 273123013891 ABC-ATPase subunit interface; other site 273123013892 6 probable transmembrane helices predicted by TMHMM2.0 273123013893 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273123013894 substrate binding pocket [chemical binding]; other site 273123013895 membrane-bound complex binding site; other site 273123013896 hinge residues; other site 273123013897 1 probable transmembrane helix predicted by TMHMM2.0 273123013898 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 273123013899 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 273123013900 glutaminase active site [active] 273123013901 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 273123013902 dimer interface [polypeptide binding]; other site 273123013903 active site 273123013904 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 273123013905 dimer interface [polypeptide binding]; other site 273123013906 active site 273123013907 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 273123013908 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 273123013909 Substrate binding site; other site 273123013910 Mg++ binding site; other site 273123013911 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 273123013912 active site 273123013913 substrate binding site [chemical binding]; other site 273123013914 CoA binding site [chemical binding]; other site 273123013915 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 273123013916 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 273123013917 gamma subunit interface [polypeptide binding]; other site 273123013918 epsilon subunit interface [polypeptide binding]; other site 273123013919 LBP interface [polypeptide binding]; other site 273123013920 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 273123013921 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 273123013922 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 273123013923 alpha subunit interaction interface [polypeptide binding]; other site 273123013924 Walker A motif; other site 273123013925 ATP binding site [chemical binding]; other site 273123013926 Walker B motif; other site 273123013927 inhibitor binding site; inhibition site 273123013928 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 273123013929 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 273123013930 core domain interface [polypeptide binding]; other site 273123013931 delta subunit interface [polypeptide binding]; other site 273123013932 epsilon subunit interface [polypeptide binding]; other site 273123013933 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 273123013934 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 273123013935 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 273123013936 beta subunit interaction interface [polypeptide binding]; other site 273123013937 Walker A motif; other site 273123013938 ATP binding site [chemical binding]; other site 273123013939 Walker B motif; other site 273123013940 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 273123013941 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 273123013942 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 273123013943 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 273123013944 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 273123013945 1 probable transmembrane helix predicted by TMHMM2.0 273123013946 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 273123013947 2 probable transmembrane helices predicted by TMHMM2.0 273123013948 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 273123013949 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 273123013950 5 probable transmembrane helices predicted by TMHMM2.0 273123013951 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 273123013952 4 probable transmembrane helices predicted by TMHMM2.0 273123013953 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 273123013954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273123013955 S-adenosylmethionine binding site [chemical binding]; other site 273123013956 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 273123013957 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 273123013958 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932